CN106074437A - The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing and production method thereof - Google Patents
The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing and production method thereof Download PDFInfo
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- CN106074437A CN106074437A CN201610548935.2A CN201610548935A CN106074437A CN 106074437 A CN106074437 A CN 106074437A CN 201610548935 A CN201610548935 A CN 201610548935A CN 106074437 A CN106074437 A CN 106074437A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention discloses seaweed polysaccharide plant empty capsules and the production method thereof of a kind of not plasticizer-containing, use alginate jelly and plant gum compounding as gel, and use cellulose derivative as film former and disintegrating agent, potassium salt is as flocculation aid, and uses vacuum defoaming device and low temperature and low humidity drying process to prepare high-quality seaweed polysaccharide plant empty capsules.The practical significance of the present invention is, traditional animal gelatin is replaced to prepare plant hollow capsule with the vegetable polysaccharides of safety and Health, compound gel by alginate jelly Yu plant gum, avoid the hydrophilic plasticizer defect such as cause the moisture absorption of capsule tacky, prepare compact structure, plant hollow capsule that degree of stability is high, it is achieved the industrialized production of high-quality seaweed polysaccharide plant empty capsules.
Description
Technical field
The present invention relates to a kind of plant hollow capsule and preparation technology thereof, the Sargassum being specifically related to a kind of not plasticizer-containing is many
Sugar plant hollow capsule and dip in the preparation technology of glue at a lower temperature.
Background technology
Capsule has to be covered bad smell, appearance looks elegant, has insulation blocking effect, content to release unstable content
Put that absorptance tablet is high, easily realize medicine alignment system, can improve the compliance taken and the advantage such as production technology is simple,
Functional food, health food and medicine are applied quite varied, the most indispensable in modern medicine.At present, on market
90% is animal gelatin capsule, and the market share of plant capsule is the lowest.Owing to animal gelatin Capsules is by gelatin, sweet
Oil and water are made, and gelatin is mainly derived from skin and the bone of animal body, and its volatile water hardening of Capsules prepared becomes fragile and causes glue
Capsule is broken, hygroscopic softening causes content caking, meet the medicines such as aldehyde material, recuding sugars compound and vitamin C easily sends out
Raw crosslinking causes Capsules water solublity to be deteriorated, and disintegrate is transfinited and content dissolution delay etc..It addition, gelatin hollow capsule is deposited
At zoonosis risk and the report of " toxic capsule " event, the use of gelatin hollow capsule is caused to there is huge safety hidden
Suffer from.Furthermore, due to the factor in terms of faith and religion, Islam and China's Some Minority Races territorial restrictions animal is bright
The use of glue capsule.By contrast, the moisture of plant hollow capsule is low, up to 2～7%, is difficult to moisture absorption, beneficially content
The stability of thing, is especially suitable for hygroscopicity strong and to the medicine of moisture-sensitive or health product, have that toughness is strong simultaneously, good springiness,
The non-efflorescing cementitious broken advantage such as crisp.It addition, plant hollow capsule is without the proteotoxin of animal gelatin, without residual harmful substance in animal body
Or the potential risk polluted, it is not necessary to ethylene oxide sterilizing, without advantages such as any preservative, meanwhile, meet particular culture letter
Face upward the requirement of crowd and vegetarian.Therefore, along with the raising of health of people consciousness, health-product market is increasingly burning hot, these
Reason all promotes the rapid rising of the plant hollow capsule market demand.
Prevailing due to plant hollow capsule, many vegetable polysaccharidess are constantly developed application.The hollow glue of majority of plant
Capsule is made up of native cellulose derivant, modified starch and vegetable polysaccharides.Hydroxypropyl cellulose and modified starch usually used as
Main film-former, and as important gel agent composition, generally choose Sargassum polysaccharides, microbial polysaccharide etc..Plant hollow capsule
Physicochemical property aspect, owing to a high proportion of starch makes Capsules fragility big as film former, and the most single card of Sargassum polysaccharides
Glue is drawn to cause plant hollow capsule syneresis that friability is increased.In view of with present on shortcoming, in order to increase its plasticity,
Reduce friability majority of plant Capsules and all introduce hydrophilic plasticizer, including glycerol, Polyethylene Glycol (PEG) and table
The auxiliary agents such as face activating agent Tween, Span.Although the use of plasticizer can significantly improve the plasticity of plant hollow capsule, toughness, but
Also can increase the hygroscopicity of capsule shells, situation of going mouldy, reduce the stability in its storage process.
Summary of the invention
It is an object of the invention to provide the plant hollow capsule of a kind of not plasticizer-containing, its not plasticizer-containing, reduction storage
The hydroscopicity of softgel shell and the tacky degree on softgel shell surface during Tibetan, can keep physicochemical property and the machinery that softgel shell is good simultaneously
Performance.
It is a further object of the present invention to provide the production method of the plant hollow capsule of a kind of not plasticizer-containing, it has work
The feature that skill is simpler.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of seaweed polysaccharide plant empty capsules of not plasticizer-containing, including 0.5～5wt% plant pluralgel agent, 5～
45wt% film former and 50～94.5wt% distilled water；Described plant pluralgel agent includes that weight ratio is 36:16:1～40:5:
Sargassum polysaccharides, plant gum and the potassium salt of 2；Described film former includes cellulose derivative and the modification that weight ratio is 1:1～5:1
Starch.
Described Sargassum polysaccharides is the mixture of one or more in kappa-carrageenan, sodium alginate, agar.
Described plant gum is one or more in locust bean gum, guar gum, sesbania gum, fenugreek gum, Semen Lini glue
Mixture.
Described potassium salt is the mixture of one or more in potassium chloride, potassium carbonate, potassium citrate.
Described cellulose derivative uses low-viscosity hydroxypropylmethylc,llulose, hydroxypropyl cellulose, carboxymethyl cellulose
In the mixture of one or more.
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing, comprises the following steps:
(1) colloidal sol: by weight, successively using potassium salt, plant gum and the Sargassum polysaccharides as plant pluralgel agent
Add in distilled water, be gradually heating to 80～95 DEG C and make described plant pluralgel agent and film former the most swelling, and keep one
In the fixed response time, obtain colloidal sol；Wherein, the consumption of the agent of plant pluralgel, film former and distilled water be respectively 0.5～
5wt%, 5～45wt% and 50～94.5wt%；Sargassum polysaccharides, plant gum and the weight ratio of potassium salt in plant pluralgel agent
For 36:16:1～40:5:2.
(2) vacuum defoamation: at a temperature of 40～70 DEG C, carries out de-bubble, vacuum by described colloidal sol employing vacuum defoaming device
Degree controls 0.05～0.1MPa, and the process time is 1.5～4h, obtains glue；
(3) glue base is dipped in: the stainless steel mould of oiling is dipped in the described glue of 40～50 DEG C glue 3～5 seconds, turning mould
Bar three times is to be dried；
(4) be dried: through step (3) process after mould 30～50 DEG C, RH be 30～60%, dried 1.0～
5.0h；
(5) carry out the most successively cooling down, pulling out shell, shearing, fit, obtain the seaweed polysaccharide plant empty glue of not plasticizer-containing
Capsule.
Described Sargassum polysaccharides is the mixture of one or more in kappa-carrageenan, sodium alginate, agar.
Described plant gum is one or more in locust bean gum, guar gum, sesbania gum, fenugreek gum, Semen Lini glue
Mixture.
Described potassium salt is the mixture of one or more in potassium chloride, potassium carbonate, potassium citrate.
Described film former includes cellulose derivative and the modified starch that weight ratio is 1:1～5:1, and described cellulose derives
Thing uses the mixture of one or more in low-viscosity hydroxypropylmethylc,llulose, hydroxypropyl cellulose, carboxymethyl cellulose.
After using technique scheme, the present invention uses alginate jelly and plant gum compounding as gel, and uses fibre
Dimension element derivant is as film former and disintegrating agent, and potassium salt is as flocculation aid, and uses vacuum defoaming device and low temperature and low humidity to do
Drying process prepares high-quality seaweed polysaccharide plant empty capsules.The practical significance of the present invention is, the plant with safety and Health is many
Sugar replaces traditional animal gelatin to prepare plant hollow capsule, by the compound gel of alginate jelly Yu plant gum, it is to avoid hydrophilic
The property plasticizer defect such as cause the moisture absorption of capsule tacky, prepares compact structure, plant hollow capsule that degree of stability is high, prepares
The plant hollow capsule come can reduce the hydroscopicity of softgel shell in storage and the tacky degree on softgel shell surface, can keep simultaneously
Physicochemical property that softgel shell is good and mechanical performance, it is achieved the industrialized production of high-quality seaweed polysaccharide plant empty capsules.
It addition, the preparation technology route of plant hollow capsule generally include colloidal sol, be incubated, dip in glue, be dried, pull out shell, suit,
Fit, it it is critical only that and dip in glue step, keeps certain glue temperature of dipping in make the viscosity of glue reach optimum to dip in glue scope.And phase
Dip in glue temperature be about 50 DEG C than in tradition gelatin hollow capsule, plant hollow capsule to dip in glue temperature higher than gelatin hollow capsule,
Dip in glue temperature according to capsule material difference and be generally 55-65 DEG C, be 65 DEG C as CN104436204 dips in glue temperature, of a relatively high；
CN104274424/CN10407281 dips in glue temperature and is 50-60 DEG C, relative to the present invention to dip in glue temperature the highest；Mistake of the present invention
In journey, plant compound adhesive is prepared the glue temperature of dipping in of Capsules and is 40-50 DEG C so that the preparation technology of Capsules is simpler,
It is suitable for the preparation method of the plant hollow capsule of enterprise's industrialized production.
Detailed description of the invention
Referring to specific embodiment, the present invention is described.Only it will be appreciated by those skilled in the art that these embodiments
For the present invention is described, it limits the scope of the present invention never in any form.
Experimental technique in following embodiment, if no special instructions, is conventional method.Medicine used in following embodiment
Material raw material, reagent material etc., if no special instructions, be commercially available purchase product.
Embodiment 1:
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing, comprises the following steps:
(1) colloidal sol: successively using 0.1g potassium carbonate, 0.3g locust bean gum and the 0.8g κ-OK a karaoke club as plant pluralgel agent
Glue is sequentially added in 85mL distilled water, is gradually heating to 90 DEG C under stirring, adds the 10g 3～30cP carboxymethyl as film former
Cellulose and 5g hydroxypropyl starch, low rate mixing 0.5h makes plant pluralgel agent and film former the most swelling, obtains swelling mixed
Compound, with the weight of this swollen mixt for radix moisturizing 4wt%, obtains colloidal sol；
(2) vacuum defoamation: described colloidal sol is used vacuum defoaming device is 55 DEG C, the bar of vacuum 0.08MPa in temperature
Under part, low rate mixing de-bubble 1.5h, obtains glue；
(3) glue base is dipped in: the stainless steel mould of oiling is dipped in the described glue of 45 DEG C glue 3～5 seconds, overturns tringle three
Secondary to be dried；
(4) be dried: through step (3) process after mould 33 DEG C, RH be 36%, dried 2.5h；
(5) being cooled to room temperature, then carry out successively pulling out shell, shearing, fit, the seaweed polysaccharide plant obtaining not plasticizer-containing is empty
Heart-soothing capsule.
Embodiment 2:
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing, comprises the following steps:
(1) colloidal sol: by weight, successively using as the potassium chloride of 0.2g of plant pluralgel agent, 0.4g locust bean gum
Glue and the kappa-carrageenan with 1.2g are sequentially added in 85mL distilled water, are gradually heating to 90 DEG C under stirring, add as film former
The hydroxypropyl methyl cellulose of 10g 3～30cP and 5g hydroxypropyl starch, low rate mixing 0.5h make plant pluralgel agent and
Film former is the most swelling, obtains swollen mixt, with the weight of this swollen mixt for radix moisturizing 4wt%, obtains colloidal sol；
(2) vacuum defoamation: described colloidal sol is used vacuum defoaming device is 55 DEG C, the bar of vacuum 0.08MPa in temperature
Under part, low rate mixing de-bubble 3h, obtains glue；
(3) glue base is dipped in: the stainless steel mould of oiling is dipped in the described glue of 50 DEG C glue 3～5 seconds, overturns tringle three
Secondary to be dried；
(4) be dried: through step (3) process after mould 45 DEG C, RH be 40%, dried 2.5h；
(5) being cooled to room temperature, then carry out successively pulling out shell, shearing, fit, the seaweed polysaccharide plant obtaining not plasticizer-containing is empty
Heart-soothing capsule.
Embodiment 3:
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing, comprises the following steps:
(1) colloidal sol: by weight, successively using as the potassium citrate of 0.1g of plant pluralgel agent, the fine jade of 0.2g
The kappa-carrageenan of fat, 0.2g locust bean gum and 0.8g is sequentially added in 85mL distilled water, is gradually heating to 90 DEG C under stirring, adds
As the hydroxypropyl methyl cellulose of 10g 3～30cP and the 5g hydroxypropyl starch of film former, low rate mixing 0.5h makes plant multiple
Close gel and film former is the most swelling, obtain swollen mixt, with the weight of this swollen mixt for radix moisturizing 4wt%,
Obtain colloidal sol；
(2) vacuum defoamation: described colloidal sol is used vacuum defoaming device is 55 DEG C, the bar of vacuum 0.08MPa in temperature
Under part, low rate mixing de-bubble 1.5h, obtains glue；
(3) glue base is dipped in: the stainless steel mould of oiling is dipped in the described glue of 48 DEG C glue 3～5 seconds, overturns tringle three
Secondary to be dried；
(4) be dried: through step (3) process after mould 45 DEG C, RH be 40%, dried 2.5h；
(5) being cooled to room temperature, then carry out successively pulling out shell, shearing, fit, the seaweed polysaccharide plant obtaining not plasticizer-containing is empty
Heart-soothing capsule.
The physicochemical property that the plant hollow capsule prepared by above example is contrasted with commercially available gelatin hollow capsule is as follows:
Above-described embodiment is only used for illustrating the inventive concept of the present invention, rather than the restriction to rights protection of the present invention,
All changes utilizing this design that the present invention carries out unsubstantiality, all should fall into protection scope of the present invention.
Claims (10)
1. the seaweed polysaccharide plant empty capsules of a not plasticizer-containing, it is characterised in that: include that 0.5～5wt% plant is combined
Gel, 5～45wt% film former and 50～94.5wt% distilled water；Described plant pluralgel agent includes that weight ratio is 36:
The Sargassum polysaccharides of 16:1～40:5:2, plant gum and potassium salt；Described film former includes the cellulose that weight ratio is 1:1～5:1
Derivant and modified starch.
The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 1, it is characterised in that: described
Sargassum polysaccharides is the mixture of one or more in kappa-carrageenan, sodium alginate, agar.
The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 1, it is characterised in that: described
Plant gum is the mixture of one or more in locust bean gum, guar gum, sesbania gum, fenugreek gum, Semen Lini glue.
The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 1, it is characterised in that: described
Potassium salt is the mixture of one or more in potassium chloride, potassium carbonate, potassium citrate.
The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 1, it is characterised in that: described
Cellulose derivative uses the one or many in low-viscosity hydroxypropylmethylc,llulose, hydroxypropyl cellulose, carboxymethyl cellulose
The mixture planted.
6. the production method of the not seaweed polysaccharide plant empty capsules of plasticizer-containing, it is characterised in that comprise the following steps:
(1) colloidal sol: by weight, adds potassium salt, plant gum and the Sargassum polysaccharides as plant pluralgel agent successively
In distilled water, it is gradually heating to 80～95 DEG C and makes described plant pluralgel agent and film former the most swelling, and keep certain
In the response time, obtain colloidal sol；Wherein, the consumption of the agent of plant pluralgel, film former and distilled water is respectively 0.5～5wt%, 5
～45wt% and 50～94.5wt%；In plant pluralgel agent, the weight ratio of Sargassum polysaccharides, plant gum and potassium salt is 36:
16:1～40:5:2.
(2) vacuum defoamation: at a temperature of 40～70 DEG C, carries out de-bubble, vacuum control by described colloidal sol employing vacuum defoaming device
System is 0.05～0.1MPa, and the process time is 1.5～4h, obtains glue；
(3) glue base is dipped in: the stainless steel mould of oiling is dipped in the described glue of 40～50 DEG C glue 3～5 seconds, overturns tringle three
Secondary to be dried；
(4) be dried: through step (3) process after mould 30～50 DEG C, RH be 30～60%, dried 1.0～5.0h；
(5) carry out the most successively cooling down, pulling out shell, shearing, fit, obtain the seaweed polysaccharide plant empty capsules of not plasticizer-containing.
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 6, it is special
Levy and be: described Sargassum polysaccharides is the mixture of one or more in kappa-carrageenan, sodium alginate, agar.
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 6, it is special
Levy and be: described plant gum is one or more in locust bean gum, guar gum, sesbania gum, fenugreek gum, Semen Lini glue
Mixture.
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 6, it is special
Levy and be: described potassium salt is the mixture of one or more in potassium chloride, potassium carbonate, potassium citrate.
The production method of the seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing the most according to claim 6, it is special
Levying and be: described film former includes cellulose derivative and the modified starch that weight ratio is 1:1～5:1, described cellulose derives
Thing uses the mixture of one or more in low-viscosity hydroxypropylmethylc,llulose, hydroxypropyl cellulose, carboxymethyl cellulose.
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Cited By (6)
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| CN106902093A (en) * | 2017-01-24 | 2017-06-30 | 华侨大学 | A kind of plant enteric hollow capsule and its production method |
| CN109528678A (en) * | 2019-01-14 | 2019-03-29 | 武汉海吉亚生物科技有限公司 | A kind of hydroxypropyl methylcellulose capsules and its preparation method and application |
| CN109528676A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of seaweed polysaccharide plant soft capsule and preparation method thereof |
| CN111454490A (en) * | 2020-04-14 | 2020-07-28 | 中国科学院化学研究所 | Composition for preparing edible plant plasma membrane and application thereof |
| CN112057433A (en) * | 2020-09-08 | 2020-12-11 | 华侨大学 | Preparation method of composite plant hard capsule shell |
| CN112089701A (en) * | 2020-10-30 | 2020-12-18 | 华侨大学 | Vitamin E plant soft capsule shell and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN109528678A (en) * | 2019-01-14 | 2019-03-29 | 武汉海吉亚生物科技有限公司 | A kind of hydroxypropyl methylcellulose capsules and its preparation method and application |
| CN111454490A (en) * | 2020-04-14 | 2020-07-28 | 中国科学院化学研究所 | Composition for preparing edible plant plasma membrane and application thereof |
| CN111454490B (en) * | 2020-04-14 | 2021-10-22 | 中国科学院化学研究所 | Composition for preparing edible plant plasma membrane and application thereof |
| CN112057433A (en) * | 2020-09-08 | 2020-12-11 | 华侨大学 | Preparation method of composite plant hard capsule shell |
| CN112089701A (en) * | 2020-10-30 | 2020-12-18 | 华侨大学 | Vitamin E plant soft capsule shell and application thereof |
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Application publication date: 20161109 |