CN106074304A - A kind of containing hyaluronate sodium microsphere and the anti-aging cosmetics compositions with smooth out wrinkles, even skin effect of peptide - Google Patents
A kind of containing hyaluronate sodium microsphere and the anti-aging cosmetics compositions with smooth out wrinkles, even skin effect of peptide Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61Q19/08—Anti-ageing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of containing hyaluronate sodium microsphere and the anti-aging cosmetics compositions with smooth out wrinkles, even skin effect of peptide, it is made up of the raw material of following weight/mass percentage composition: hyaluronate sodium microsphere 0.5～3.0%, palmityl tripeptides 0.5～3.0%, root extract Radix Ophiopogonis 0.5～5.0%, hyaluronate sodium moisturizing complex 0.5～5.0%, surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.The active component of this cosmetic composition includes hyaluronate sodium microsphere, palmityl tripeptides, root extract Radix Ophiopogonis, hyaluronate sodium moisturizing complex.Utilize various composition reasonable combination, cooperation to share, increasing skin moisture content, improving xerosis cutis, on the basis of rebuilding skin barrier, reached the senile-resistant efficacy of smooth out wrinkles, even skin by the interpolation of hyaluronate sodium microsphere, small-molecule peptide.
Description
Technical field
The invention belongs to cosmetic composition technical field, be specifically related to a kind of having containing hyaluronate sodium microsphere and peptide
Smooth out wrinkles, the anti-aging cosmetics compositions of even skin effect.
Background technology
With the growth at age, the natural aging that skin is affected by endogenous factor, show as cutis laxa, occur tiny
Wrinkle, xerosis cutis, desquamation, fragility increase simultaneously, and repair function goes down.In horny layer, water is important molded article, horny layer
Middle moisture is about 10%～15%, and the relative constancy of water depends on nature moisturizing factor, including aminoacid, pyrrolidine
The acid of ketone hydroxy acid, lactate, carbamide, urea, creatine, phosphate etc..Increase with the age, nature moisturizing factor content in keratodermatitis
Reduce, make skin hydration ability decline, only the 75% of normal skin.Wrinkle of skin increases, and the surface area of skin increases, moisture
Losing and increase, therefore natural aging first appears as xerosis cutis.
With advancing age, the ability of cells in vivo synthesis hyaluronic acid (HA) declines.HA is epiderm skin, corium group
One of main component knitted, accounts for 70% of acid mucopolysaccharide contained by skin.HA and protein bound in skin, with complex
Form is present in iuntercellular, forms gel and is sticked together by cell.It has the critical function of regulation of skin moisture, makes skin have
There are certain tenacity and elasticity.In human body, HA content declines, and skin histology thickness reduces, and skin elasticity reduces, degree of roughness
Increasing, there is wrinkle in skin.Wrinkle can be fine wrinkle and the deep wrinkle of epidermis, the least wrinkle and big wrinkle, little wrinkle be by
Losing in moisture of skin, collagen fiber and elastic fibers reduce so that what cutis laxa caused, and big wrinkle is then at cutis laxa
On the basis of, can not get because the muscle under skin shrinks for a long time alleviating formation.
The approach of anti-aging cosmetics defying age in the market is concentrated mainly on three big aspects: (1) removed
The reactive oxygen free radical of amount；(2) cell metabolism is promoted；(3) elastin laminin of the collagen protein in supplementary skin.Although this
Three big approach can solve most of problem of ageing skin, but increases skin moisture content, improves xerosis cutis, rebuilds skin
Barrier, is smooth out wrinkles, even skin approach the most efficiently.
To cause skin aging reason be various and the aging to skin often of these numerous reasons plays solely
From effect, the most each reason can cause the aging of skin.So, when developing anti-aging product, skin to be considered
Old and feeble reason, acts on from multipath simultaneously, can be only achieved more preferably anti-aging effects.But it is anti-ageing to take multipath effect
Always, it is necessary to consider safety, otherwise skin can be produced serious injury simultaneously, the most not only can not defying age, accelerate on the contrary
Skin aging.
Summary of the invention
It is an object of the invention to provide and a kind of containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin merit
Effect anti-aging cosmetics compositions, the active component of this cosmetic composition include hyaluronate sodium microsphere, small-molecule peptide,
Natural botanical extraction liquid and moisturizing complex, utilize various composition reasonable combination, cooperation to share, increasing skin moisture content,
Improve xerosis cutis, on the basis of rebuilding skin barrier, reach to smooth by the interpolation of hyaluronate sodium microsphere, small-molecule peptide
Wrinkle, the senile-resistant efficacy of even skin.
The above-mentioned purpose of the present invention is achieved through the following technical solutions: a kind of containing hyaluronate sodium microsphere and peptide
There is the anti-aging cosmetics compositions of smooth out wrinkles, even skin effect, be made up of the raw material of following weight/mass percentage composition:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
The active component of the anti-aging cosmetics compositions in the present invention include hyaluronate sodium microsphere, palmityl tripeptides,
Radix Ophiopogonis root extract and hyaluronate sodium moisturizing complex.
The present invention first selects natural botanical extraction liquid and moisturizing complex to reach to increase skin moisture content, improves skin
Being dried, rebuild effect of skin barrier, reselection hyaluronate sodium microsphere, small-molecule peptide reach smooth out wrinkles, smooth skin
The senile-resistant efficacy of skin, the mode of this combination and cooperation, for reaching safe and effective anti-aging effects, has very important meaning
Justice.
As a kind of preferably technical scheme of the present invention, the anti-aging cosmetics compositions in the present invention is by following quality
The raw material of percentage composition is made:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
As the one more preferably technical scheme of the present invention, the anti-aging cosmetics compositions in the present invention is by following quality
The raw material of percentage composition is made:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
In above-mentioned anti-aging cosmetics compositions:
Described hyaluronate sodium microsphere is commercially available prod, is preferably less than hyaluronate sodium and the molecule of 40kDa by molecular weight
The amount SKGM crosslinking dehydration higher than 200kDa is formed.
The principle with hygroscopic effect bead is: first bead is dehydrated, and after the bead of dehydration enters skin, water-filling expands,
In water filling process, the volume of bead increases, and has the strongest moisture holding capacity.Within a short period of time, skin changed, deep layer
Wrinkle becomes the most obvious.Life-time service can find the improvement of deep skin time, and apparent change is relative to profound improvement
Much faster.
Hyaluronate sodium microsphere in the present invention is also the microsphere with hygroscopic effect, and this microsphere is by two kinds of biopolymers
Composition: SKGM (＞ 200kDa) the crosslinking dehydration of low molecular weight sodium hyaluronate (＜ 40kDa) and high molecular is formed.Thoroughly
Bright matter acid sodium to effect of skin it is known that selecting low molecular weight sodium hyaluronate is because its water absorption is more preferable.SKGM
Being a kind of vegetable polysaccharides, wettability power is remarkable, can absorb the moisture of himself weight 200 times.Amorphophallus aroid, from
So being grown on the forest of Thailand, Vietnam and southern china, its wettability power is strong.The microsphere that dehydrated crosslinking is formed can penetrate into
Epidermis upper strata, absorbs the moisture being evaporated from skin deep layer.Due to its water absorption character, microsphere volume increases rapidly, after expansion
Make skin more compact, smooth out wrinkles, make skin surface more smooth, more can increase elasticity of skin, long-acting moisturizing can be had again
Effect.Therefore, hyaluronate sodium microsphere can quick smooth out wrinkles, make skin surface become smooth, life-time service can improve wrinkle,
Long-acting moisturizing.
As the present invention one preferred embodiment, palmityl tripeptides of the present invention is the sweet of palmityl tripeptides
Oil solution.
Every L glycerol aqueous solution preferably comprises palmityl tripeptides 200～300mg.
Herein in regard to the glycerine water solution that palmityl tripeptides is palmitic acid acyl tripeptides, the only application of palmityl tripeptides one of which
Enumerate, not for limiting.
Palmityl tripeptides is commercially available prod, derives from synthesis, purifies, is native peptides Pal-based on a kind of titanium dioxide
KMO2K, sequence is palmityl-lysyl-dioxy methionyl-lysine (Palmitoyl-Lysyl-Dioxymethionyl-
Lysine)。Pal-KMO2K can promote the synthesis of extracellular matrix macromole, and therefore it shows the work as matrikines
Property." Matrikines " is one section and is less than or equal to 20 aminoacid sequences, is the front dermal matrix that not yet heals after skin is hindered
Hydrolyzate.Collagen protein, elastin laminin and the hydrolysis of fibronectin Pseudobulbus Bletillae (Rhizoma Bletillae) fibrin produce soluble peptide, these solubilities
Peptide is autocrine and Paracrine courier, can regulate wound healing proteins and express.Matrikines contains pentapeptide KTTKS
(being referred to as MATRL, derive from procollagen a1 chain hydrolyzate), tripeptides GHK are (from I-type collagen a2 chain water
Hydrolysis products) and other are various from elastin laminin with the peptide fragment of Kallinin.Matrikines can be to connective tissue
Rebuild and proliferation process carries out feedback regulation, can generate substantial amounts of more than under the normal physiological cycle during skin repair
Skin repair albumen.So Pal-KMO2K can promote skin substrate and epidermis and 6 kinds of key elements in corium articulamentum (DEJ)
Synthesis, these 6 kinds of key elements are NTx albumen, III collagen type, type Ⅳ collagen albumen, laminin，LN, fibronectin
In vain, hyaluronic acid.Therefore skin can be made smooth, full from skin internal filling wrinkles on one's forehead and crows-feet.
As the present invention one preferred embodiment, described root extract Radix Ophiopogonis is commercially available prod, it is preferred that its
Solid content is preferably 90～130g/L, rich in levan Radix Ophiopogonis of purification, analyzes the molecular weight of its levan from spectrum
Between 500 to 7500 dalton.
Root extract Radix Ophiopogonis in the present invention, latin name is OPHIOPOGON JAPONICUS, from the tuber rich in Radix Ophiopogonis
Middle purification.Originate from Asia, be widely used on Chinese medicine, because the tuber of Radix Ophiopogonis contains mucopolysaccharide so it has very
Good lock aqueous energy.Activate epidermis lipid synthesis and optimize its tissue, strengthening epidermis and connect, and activation keratinocyte differentiation is
Skin keeps three biological mechanisms of water balance.The spectral signature of the most dry skin is with normal to use Raman spectrum may determine that
The Main Differences of skin is the organizational structure of epidermis lipid.Radix Ophiopogonis contained by Radix Ophiopogonis root extract, levan can increase Claudin-1
(forming transmembrane protein necessary to compact siro spinning technology) and Zonula Occludens-1 (zonula occludens albumen-1) synthesis, formed tight
Cause connect network and improve the level of horny layer NMF (nature moisturizing factor), improve the peridermal adhesive force of table, thus activate table
Skin lipid synthesis also optimizes its tissue, strengthens epidermis and connects, the barrier function of restructuring skin.Claudin-1 (forms compact siro spinning technology
Necessary transmembrane protein) and Zonula Occludens-1 (zonula occludens albumen-1) be main tight junction protein,
Cell tracking and barrier function balance aspect play an important role.Loricrin and silk polyprotein are horny layer forming processes
In protein.Silk polyprotein is that profilaggrin converts and the protein that produces under the facilitation of enzyme, and it is at cutin
The bottom crude fibre of layer aggregates into keratin filament, is therefore a part for epidermal area structure.Radix Ophiopogonis, root extract was through
Activate the synthesis of silk polyprotein thus promote keratinocyte differentiation.Therefore, root extract Radix Ophiopogonis is by activating epidermis lipid synthesis also
Optimize its tissue, reinforcement epidermis connection, and activation keratinocyte differentiation thus promote skin moisturizing, rebuild skin barrier.
As the present invention one preferred embodiment, hyaluronate sodium moisturizing complex of the present invention is commercially available
Product, preferred complex composition and ratio, this hyaluronate sodium moisturizing complex is made up of the raw material of following weight/mass percentage composition:
Hyaluronate sodium 0.05～0.1%, glycerol 37～42%, water 31～38%, Anjidew NL50 5～11%, carbamide 5～11%, trehalose
1～4%, triacetyl glycerine 0.1～0.7%, polyquaternary ammonium salt-51 0.1～1%.
The chemical composition of human body, can be to maintenance skin so skin carries out certain moisturizing containing about the water more than 70%
Healthy and attractive in appearance extremely important.Elastic, smooth and softness is all healthy skin important feature, and its major part depends primarily on
Water content in skin.The skin of dehydration can become to be dried and fragile, and the internal structure of skin can be destroyed.Over time
Loss, the change of environment and the reason at age can make the born moisturizing miopragia of skin, and result causes xerosis cutis shape
Become microgroove and wrinkle.
Water holding composition polyquaternary ammonium salt-51 is the basic platform of this moisturizing complex so that it is its lock water constituent hyaluronate sodium,
Carbamide, Anjidew NL50, saccharide, glycerol are attached on skin.In addition to promoting the absorption to water and holding capacity, also can be at skin table
Face forms a tunic and helps to stop the loss of moisture, and stablizes filmated skin texture.Hyaluronic acid plus high molecular
The addition of a kind of generally acknowledged effective moisturizing ingredient of sodium, makes moisture-keeping efficacy reach optimal as far as possible.Trehalose is as this moisturizing
Complex is strengthened, and this polysaccharide can play the part of the role of " locking ", it is ensured that all of moisturizing ingredient is enclosed by polymer nature structure
System, and keep the connection with skin surface.Therefore, this moisturizing complex is a 3 D stereo moisture-keeping system, and water absorbent surface is protected
Wet, surface filming moisturizing, deep layer repair moisturizing, form barrier at skin surface, firmly pin moisture.
The dosage form of the cosmetic composition of the present invention preferably multiple system that can be accepted such as cream shape or emulsion form
Agent form.Prepared by the conventional method that can use this area.
The invention have the advantages that what the present invention contained hyaluronate sodium microsphere and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics compositions of effect contain can quickly smooth out wrinkles, to make skin surface become smooth filled-type composition transparent
Matter acid sodium microsphere, can promote skin substrate and epidermis and the defying age Petiolus Trachycarpi of the synthesis of 6 kinds of key elements in corium articulamentum (DEJ)
Acyl tripeptides, by activate epidermis lipid synthesis and optimize its tissue, strengthen epidermis connect and activation keratinocyte differentiation thus
Promote skin moisturizing, root extract Radix Ophiopogonis of reconstruction skin barrier, repaiied by water absorbent surface moisturizing, surface filming moisturizing, deep layer
Answer moisturizing thus form barrier at skin surface, firmly pin the hyaluronate sodium moisturizing complex of moisture, four kinds of active component
Synergism reaches the senile-resistant efficacy of smooth out wrinkles, even skin.
Accompanying drawing explanation
Fig. 1 is keratodermatitis water content test figure in embodiment 6；
Fig. 2 is that in embodiment 6, forehead expression stricture of vagina improves result figure interior change in 6 hours, before the most left figure is use, in
Between figure be to use after 1 hour, after right figure be use 6 hours；
Fig. 3 is that in embodiment 6, canthus fishtail line improves result figure, before the most left figure is use, after right figure is use.
Detailed description of the invention
The present invention provide containing hyaluronate sodium microsphere and peptide have smooth out wrinkles, even skin effect anti-ageing aging
Cosmetic compositions, this cosmetic composition has quick smooth out wrinkles, smooth skin, long-acting anti-ageing effect, with hyaluronic acid
Sodium microsphere, palmityl tripeptides, root extract Radix Ophiopogonis, hyaluronate sodium moisturizing complex are chief active additive, and interpolation
Cosmetic commonly uses matrix components emulsifying agent, oils and fats, wetting agent, thickening agent, preservative, essence, deionized water, purified water and distilled water
In one or more make.
Embodiment 1
Comfort wrinkle newborn:
Form the above-mentioned component comforting wrinkle breast and weight/mass percentage composition be:
Oil phase:
Aqueous phase:
After emulsifying, high temperature adds:
Triethanolamine 0.10
Deionized water 1.80
After emulsifying, low temperature adds:
After oil phase, aqueous phase are heated separately to 80 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C and add palmityl tripeptides, root extract Radix Ophiopogonis, transparent
Matter acid sodium moisturizing complex, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring is all
Even, become the fine and smooth uniform emulsion of white after 35 DEG C of placements.
Hyaluronate sodium microsphere is the UItra Filling Spheres of BASF (BASF) company of commercially available Germany, and this is micro-
Ball is low molecular weight sodium hyaluronate (<40kDa) and the SKGM (>200kDa of high molecular) crosslinking dehydration formed.
Palmityl tripeptides is the MATRIXYL synthe ' 6 of Si Dama (SEDERMA) company of commercially available France.Palmityl tripeptides
For the glycerine water solution of palmityl tripeptides, every L glycerol aqueous solution contains palmityl tripeptides about 250mg.It is not limited to it is brown
The glycerine water solution of palmitic acid acyl tripeptides, the most only enumerates, not for limiting.
Radix Ophiopogonis root extract be commercially available France Qian Laibo (SILAB) company COHESIUM, Radix Ophiopogonis root extract solid
Thing content is preferably 90～130g/L, the most only enumerates, not for limiting.
Hyaluronate sodium moisturizing complex is the Advanced Moisture of BASF (BASF) company of commercially available Germany
Complex。
Hyaluronate sodium moisturizing complex is 0.05～0.1% containing the mass percent of hyaluronate sodium, glycerol 37～
42%, water 31～38%, Anjidew NL50 5～11%, carbamide 5～11%, trehalose 1～4%, triacetyl glycerine 0.1～0.7%,
Polyquaternary ammonium salt-51 0.1～1%, the most only enumerates, not for limiting.
Embodiment 2
Comfort wrinkle newborn:
Form the above-mentioned component comforting wrinkle breast and weight/mass percentage composition be:
Oil phase:
Aqueous phase:
After emulsifying, high temperature adds:
Triethanolamine 0.20
Deionized water 1.80
After emulsifying, low temperature adds:
After oil phase, aqueous phase are heated separately to 80 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C and add palmityl tripeptides, root extract Radix Ophiopogonis, transparent
Matter acid sodium moisturizing complex, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring is all
Even, become the fine and smooth uniform emulsion of white after 35 DEG C of placements.
Hyaluronate sodium moisturizing complex is 0.05～0.1% containing the mass percent of hyaluronate sodium, glycerol 37～
42%, water 31～38%, Anjidew NL50 5～11%, carbamide 5～11%, trehalose 1～4%, triacetyl glycerine 0.1～0.7%,
Polyquaternary ammonium salt-51 0.1～1%, the most only enumerates, not for limiting.
Hyaluronate sodium microsphere, palmityl tripeptides, root extract Radix Ophiopogonis, the source reality together of hyaluronate sodium moisturizing complex
Execute example 1.
Embodiment 3
Comfort wrinkle white:
Form the above-mentioned component comforting wrinkle frost and weight/mass percentage composition be:
Oil phase:
Aqueous phase:
After emulsifying, high temperature adds:
Triethanolamine 0.20
Deionized water 1.80
After emulsifying, low temperature adds:
After oil phase, aqueous phase are heated separately to 80 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C and add palmityl tripeptides, root extract Radix Ophiopogonis, transparent
Matter acid sodium moisturizing complex, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring is all
Even, become the fine and smooth uniform mastic of white after 35 DEG C of placements.
Hyaluronate sodium moisturizing complex is 0.05～0.1% containing the mass percent of hyaluronate sodium, glycerol 37～
42%, water 31～38%, Anjidew NL50 5～11%, carbamide 5～11%, trehalose 1～4%, triacetyl glycerine 0.1～0.7%,
Polyquaternary ammonium salt-51 0.1～1%, the most only enumerates, not for limiting.
Hyaluronate sodium microsphere, palmityl tripeptides, root extract Radix Ophiopogonis, the source reality together of hyaluronate sodium moisturizing complex
Execute example 1.
Embodiment 4
Comfort wrinkle white:
Form the above-mentioned component comforting wrinkle frost and weight/mass percentage composition be:
Oil phase:
Aqueous phase:
After emulsifying, high temperature adds:
Triethanolamine 0.20
Deionized water 1.80
After emulsifying, low temperature adds:
After oil phase, aqueous phase are heated separately to 80 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C and add palmityl tripeptides, root extract Radix Ophiopogonis, transparent
Matter acid sodium moisturizing complex, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring is all
Even, become the fine and smooth uniform mastic of white after 35 DEG C of placements.
Embodiment 5
Comfort wrinkle white:
Form the above-mentioned component comforting wrinkle frost and weight/mass percentage composition be:
Oil phase:
Aqueous phase:
After emulsifying, high temperature adds:
Triethanolamine 0.20
Deionized water 1.80
After emulsifying, low temperature adds:
After oil phase, aqueous phase are heated separately to 80 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C and add palmityl tripeptides, root extract Radix Ophiopogonis, transparent
Matter acid sodium moisturizing complex, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring is all
Even, become the fine and smooth uniform mastic of white after 35 DEG C of placements.
The mass percent wherein containing hyaluronate sodium in hyaluronate sodium moisturizing complex is 0.05～0.1%, glycerol
37～42%, water 31～38%, Anjidew NL50 5～11%, carbamide 5～11%, trehalose 1～4%, triacetyl glycerine 0.1～
0.7%, polyquaternary ammonium salt-51 0.1～1%, the most only enumerate, not for limiting.
Hyaluronate sodium microsphere, palmityl tripeptides, root extract Radix Ophiopogonis, the source reality together of hyaluronate sodium moisturizing complex
Execute example 1.
Embodiment 6
Observation on probation
Use the present invention prepare comfort cosmetics and control sample carries out observation of curative effect
Sample: embodiment 5
Control sample: by the hyaluronate sodium microsphere in embodiment 5, palmityl tripeptides, root extract Radix Ophiopogonis, hyaluronate sodium
Moisturizing complex removes
1, moisture retention test:
Volunteer 30 people, respectively at right-hand man inner forearm labelling 4 × 4cm2Pilot region, same arm labelling 2 simultaneously
Individual region, interregional every 2cm.Using moisture of skin tester to carry out the measurement of tested region and control zone, each region is put down
Row measures 3 times.First measure the blank value of each test zone, then by 2.0 ± 0.1mg sample/cm2Consumption, use latex refer to
Sample is spread evenly across in trial zone by set.Smear that within 28 days, to measure the skin in tested region and blank region respectively aqueous
Amount.
Human detection result shows: using cosmetics of the present invention and control sample after 4 weeks, the test of keratodermatitis water content is tied
Fruit shows, cosmetics of the present invention and control sample contrast skin basic water content raising 14.1%, the most as shown in fig. 1.
2, skin elasticity assay method:
Volunteer 30 people, respectively at right-hand man's inner forearm labelling 4 × 4cm2 pilot region, same arm labelling 2 simultaneously
Individual region, interregional every 2cm.Using skin elasticity tester to carry out the measurement of tested region and control zone, each region depends on
According to parallel assay 3 times.First measure the blank value of each test zone, then by 2.0 ± 0.1mg sample/cm2Consumption, use breast
Sample is spread evenly across in trial zone by rubber finger cot.After smearing 28 days, measure the skin bullet in tested region and blank region
Property.
Human detection result shows: using after comforting wrinkle white 28 days, the elasticity of skin all has raising in various degree, averagely carries
High by 22%.
3, desalination wrinkle effect
Comforting wrinkle frost to try out through 35 people 28 days, the age, 35 human faces all had microgroove in various degree, dry stricture of vagina from 35～50 years old
More low and deep with wrinkle and blee.
Using method: every painting 2 times beyond the highest heavens, usage amount is that face is smeared uniformly.
After using 28 days, skin starts to become to moisten, smooth, and recovers gloss and elasticity, wherein 27 (77%) consumers senses
Feel that crows-feet has significantly desalination, 24 (68%) consumer sensation wrinkles to have significantly desalination.
4, to forehead expression stricture of vagina at 6 hours interior variation effects
Using cosmetics of the present invention in 6 hours, forehead expression stricture of vagina there occurs significantly desalination, and result shows, 86% be subject to
Examination person dry stricture of vagina, microgroove and expression stricture of vagina in using these cosmetics 6 hours all have desalination in various degree, and skin becomes the most flat
Sliding, the most as shown in Figure 2.
5, crows-feet is improved effect
Improvement to crows-feet: at canthus use cosmetics of the present invention (embodiment 5) after 2 months, experimenter's skin of 83%
Skin wrinkle depth shoals, and wrinkle reduces, and its result is as it is shown on figure 3, from figure 3, it can be seen that use the cosmetics 2 months of the present invention
After, wrinkle of skin depth shallower, deep wrinkles significantly reduces.
Meanwhile, experimenter's skin of face visual observations, skin becomes ruddy full, microgroove be improved significantly.
Although the present invention is open as above with embodiment, but it is not limited to protection scope of the present invention, any ripe
Know those skilled in the art, in the change made without departing from the spirit and scope of the invention and retouching, all should be belonged to this
Bright protection domain.
Claims (8)
1. the anti-aging cosmetics combination with smooth out wrinkles, even skin effect containing hyaluronate sodium microsphere and peptide
Thing, is characterized in that being made up of the raw material of following weight/mass percentage composition:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
The most according to claim 1 containing hyaluronate sodium microsphere and peptide have smooth out wrinkles, even skin effect anti-
Old and feeble cosmetic composition, is characterized in that being made up of the raw material of following weight/mass percentage composition:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
The most according to claim 1 containing hyaluronate sodium microsphere and peptide have smooth out wrinkles, even skin effect anti-
Old and feeble cosmetic composition, is characterized in that being made up of the raw material of following weight/mass percentage composition:
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
4. according to containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin described in any one of claim 1-3
The anti-aging cosmetics compositions of effect, is characterized in that: described hyaluronate sodium microsphere is commercially available prod, molecular weight be less than
The SKGM crosslinking dehydration higher than 200kDa of the hyaluronate sodium of 40kDa and molecular weight is formed.
5. according to containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin described in any one of claim 1-3
The anti-aging cosmetics compositions of effect, is characterized in that: the described glycerine water solution that palmityl tripeptides is palmityl tripeptides.
6. according to containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin described in any one of claim 1-3
The anti-aging cosmetics compositions of effect, is characterized in that: described root extract Radix Ophiopogonis is commercially available prod.
7. according to containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin described in any one of claim 1-3
The anti-aging cosmetics compositions of effect, is characterized in that: described hyaluronate sodium moisturizing complex is commercially available prod.
8. according to containing hyaluronate sodium microsphere and peptide, there is smooth out wrinkles, even skin described in any one of claim 1-3
The anti-aging cosmetics compositions of effect, is characterized in that: the dosage form of described cosmetic composition is cream shape or emulsion form.
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| CN201610613626.9A CN106074304B (en) | 2016-07-29 | 2016-07-29 | The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide |
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| CN201610613626.9A CN106074304B (en) | 2016-07-29 | 2016-07-29 | The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide |
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| CN111514055A (en) * | 2020-05-06 | 2020-08-11 | 深圳市健翔生物制药有限公司 | Cosmetic polypeptide composition granules with anti-inflammatory repair effect |
| CN111588644A (en) * | 2020-06-02 | 2020-08-28 | 浙江英树生物科技有限公司 | Moisturizing composition and preparation method and application thereof |
| CN111588644B (en) * | 2020-06-02 | 2022-08-30 | 浙江英树生物科技有限公司 | Moisturizing composition and preparation method and application thereof |
| CN112870092A (en) * | 2021-01-29 | 2021-06-01 | 广州集妍化妆品科技有限公司 | Two-phase essence and preparation method thereof |
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| CN106074304B (en) | 2019-03-05 |
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