CN106072557A - Fully nutrient preparation and application thereof for equilibrated type enteral nutrition - Google Patents

Abstract

The invention discloses a kind of fully nutrient preparation for equilibrated type enteral nutrition, including following components: alpha linolenic acid, linoleic acid, protein, glutamine, carbohydrate, dietary fiber, vitamin A, bata-carotene, vitamin D, vitamin E, vitamin K1, vitamin C, folic acid, nicotinic acid, pantothenic acid, vitamin B1, vitamin B2, vitamin B6, vitamin B12, biotin, trace element；Nutrient keeps certain quality and ratio in vivo, keep supply and the balance of consumption, it is prone to human consumption and absorption, fully meet the nutritional need of human body, normal diet can be replaced, improve gastrointestinal toleration, effectively prevent and treat the obesity caused by muscular dystrophy and overnutrition, hyperlipidemia, diabetes, cardio-cerebrovascular diseases.

Description

Fully nutrient preparation and application thereof for equilibrated type enteral nutrition

Technical field

The present invention relates to a kind of nutritional preparation, particularly to for equilibrated type enteral nutrition fully nutrient food formulation and Its application.

Background technology

Along with people's life-time dilatation, aged tendency of population is day by day obvious, due to degeneration and the impact of disease of organ dysfunction, Old people's malnutrition incidence rate is high.Adding old people's underlying diseases to increase, a variety of causes causes dysphagia and consciousness barrier Hinder, cause can not oral consumption, need tube feed patient get more and more, even want long-term band pipe existence.Due to old people's body slimming Tissue declines, various factors causes nutrient substance and liquid is taken in and reduced, and malnourished danger increases.According to foreign statistic, live Institute's gerontal patient's malnutrition is more universal, there are about 30～50%.Therefore, regardless of the nutritional status before gerontal patient such as What, all should take in energy, protein and the micronutrient of abundance.Critical patient, as cerebrovas-cularaccident, stupor, intracranial swell Tumor, operation, wound, burn etc., mostly can not oral feeding, need tube feed, owing to the state of an illness is critical, have influence on each organ merit Can, gastrointestinal digestion, absorption function are also affected；Gastrointestinal wriggling reduced capability, gastric emptying ability declines, gastric retention Increase, if food debris amount greatly, relatively thickness, emptying is relatively slow, the most easily occurs backflowing, the complication such as aspiration pneumonitis, best Method be to supply the most on a small quantity；Digestive juice secretion reduces, it is difficult to the natural food of digestion macromole and fat, the most tentatively disappears The small-molecule substance changed and suitable low fat.If critical patient's energy and nutrient substance Deficiency of Intake, affect Liver and kidney etc. important Organ function, the complication such as Hematogenous infection increases, Mechanical ventilation time and ICU extended residence time, and case fatality rate increases.Old Patient and the common ground of this two classes patient of critical patient: digestion, absorption function decline, it is difficult to tolerate common macromole food, The complication such as abdominal distention, diarrhoea easily occurs, and natural food multi-nutrient is the most complete, the intake of desired nutritional to be reached Excessive, it is difficult to meet needs；Enough energy and nutrient substance is needed to meet the special requirement of physiology and disease.At present, domestic Various natural food powder, be scarcely multipotential nutrition element, be used alone and can not fully meet nutritional need；And all-round nutrition Powder (homogenate diet), if Chinese patent application 99124658.6 and 01114638.9 is various food powders, level of residue is big, can only adopt By the method injected by several times, easily occur when consumption is big backflowing, cause the complication such as aspiration pneumonitis；Additionally, this group food needs Close to normal digestion, absorption function, the complication such as abdominal distention, diarrhoea the most easily to occur.Therefore, critical patient and old people Being used alone and be difficult to reach nutritional need, nutriture is the best；In negative correlation between nutritional status and complication, malnutrition can Increase mortality rate, infection, the generation of pressure ulcer, extend the hospital stays.Additionally, this kind of patient usually has diabetes, height Blood fat, hypertension, renal failure and other diseases, it is desirable to suitably carbohydrate, high-quality protein, relatively low fat, do not take the photograph Enter Animal fat.On the other hand, the similar import preparation (peace element, Nutrison, good meals, good meals fiber) for this two classes patient is big The most expensive, without dietary fiber, big to blood sugar influence.

Summary of the invention

In view of this, it is an object of the invention to provide a kind of fully nutrient food formulation for equilibrated type enteral nutrition And application, rich in nutrition content, content is sufficient, cooperates between each composition, and ratio is reasonable, complements each other, has collaborative Effect, it is easy to human consumption and absorption, fully meets the nutritional need of human body, can replace normal diet, improves gastrointestinal tract tolerance Property, effectively prevent and treat the obesity caused by muscular dystrophy and overnutrition, hyperlipidemia, diabetes, cardio-cerebrovascular diseases.

The fully nutrient preparation for equilibrated type enteral nutrition of the present invention, including following components:

Alpha-linolenic acid 240-260mg, linoleic acid 1-3g, protein 15-30g, glutamine 1-3g, carbohydrate 45- 65g, dietary fiber 3-10g, dehydroretinol 00-300 μ gRE, beta-carotene 80-120 μ g, vitamin D1 .5-6 μ g, vitamin E3-10mg α-TE, vitamin K1 20-40 μ g, vitamin C 40-60mg, folic acid 65-82 μ g, nicotinic acid 3-9mg, pantothenic acid 1.5-6 μ G, vitamin B1 0.05-1.2mg, vitamin B2 0.05-1.2mg, vitamin B6 0.5-3mg, vitamin B12 0.6-2 μ g, Biotin 10-25 μ g, sodium 300-400mg, potassium 450-550mg, chlorine 300-400mg, calcium 350-450mg, phosphorus 300-400mg, magnesium 60-100mg, ferrum 3-8mg, zinc 3-6mg, manganese 0.1-1.5mg, copper 0.01-0.4mg, iodine 38-60 μ g, selenium 14-22 μ g, chromium 15-25 μ g, molybdenum 8-16 μ g；

Further, including following components:

Alpha-linolenic acid 245-265mg, linoleic acid 1-2g, protein 15-25g, glutamine 1-2g, carbohydrate 50- 60g, dietary fiber 3-7g, dehydroretinol 20-280 μ gRE, beta-carotene 90-110 μ g, vitamin D1 .5-3.5 μ g, vitamin E4-7mg α-TE, vitamin K1 25-35 μ g, vitamin C 45-65mg, folic acid 70-80 μ g, nicotinic acid 4-6mg, pantothenic acid 1.5-4 μ g, Vitamin B1 0.1-0.8mg, vitamin B2 0.1-0.8mg, vitamin B6 0.5-1.5mg, vitamin B12 0.8-1.5 μ g, Biotin 10-20 μ g, sodium 330-380mg, potassium 480-520mg, chlorine 330-380mg, calcium 370-420mg, P33 0-380mg, magnesium 65-90mg, ferrum 4-7mg, zinc 3-5.5mg, manganese 0.5-1.5mg, copper 0.15-0.3mg, iodine 38-50 μ g, selenium 18-25 μ g, chromium 16- 20 μ g, molybdenum 8-14 μ g；

Further, including following components:

Alpha-linolenic acid 250mg, linoleic acid 1.5g, protein 18g, glutamine 1.5g, carbohydrate 57g, meals are fine Dimension 5g, dehydroretinol 50 μ gRE, beta-carotene 100 μ g, vitamin D2 .5 μ g, vitamin E 6mg α-TE, vitamin K1 30 μ g, Vitamin C 50mg, folic acid 75 μ g, nicotinic acid 5mg, pantothenic acid 2.5 μ g, vitamin B1 0.5mg, vitamin B2 0.5mg, vitamin B6 1mg, vitamin B12 1.2 μ g, biotin 15 μ g, sodium 350mg, potassium 500mg, chlorine 355mg, calcium 400mg, phosphorus 350mg, magnesium 80mg, ferrum 5mg, zinc 4.5mg, manganese 1mg, copper 0.25mg, iodine 45 μ g, selenium 18 μ g, chromium 20 μ g, molybdenum 12 μ g；

Further, described dietary fiber is barley diet fiber, Herba bromi japonici dietary fiber, beans dietary fiber, Radix Dauci Sativae meals One or more in fiber, Citrus dietary fiber；

Further, the carrier that can accept in medical science or bromatology or health care conduct and learning can be added and make powder, water preparation, sheet Agent, pill, granule.

Invention additionally discloses a kind of fully nutrient preparation for equilibrated type enteral nutrition at enteral nutrition health product, enteral Application in nutraceutical.

Beneficial effects of the present invention: the fully nutrient food formulation for equilibrated type enteral nutrition of the present invention, nutrition becomes Dividing abundant, content is sufficient, cooperates between each composition, and ratio is reasonable, complements each other, has synergism, and nutrient is at body Quality that interior holding is certain and ratio, keep the balance of supply and consumption to be prone to human consumption and absorption, fully meet people The nutritional need of body, can replace normal diet, improve gastrointestinal toleration, effectively preventing and treating muscular dystrophy and overnutrition institute The obesity of cause, hyperlipidemia, diabetes, cardio-cerebrovascular diseases.The fully nutrient preparation of the present invention, containing fat in every 100g powder Fat is not higher than 11g, and energy is not less than 400Kcal, and without sucrose, can increase the absorption of energy and protein, improves body egg White level, has no adverse effects to blood sugar level, hepatic and renal function, has good safety, can be by old people's prolonged application.

Wherein, protein source is sea cucumber peptide, soybean protein peptide, whey protein peptide；Carbohydrate is from various plants Starch, all kinds of modified starch, maltodextrin and/or various plant oligomeric polysaccharide, carbohydrate is taken in too much can transfer fat to, Being stored in subcutaneous and internal, cause overweight or obesity, Deficiency of Intake, make internal blood sugar level low, be short of physical strength, energy is not Good, affect brain function and run well；Alpha-linolenic acid and linoleic acid are from nut, beans and/or seafood；Sodium element nutrition mainly comes Come from sodium chloride etc.；Calcium element nutrition is mainly derived from calcium carbonate and/or calcium phosphate and/or calcium chloride and/or calcium lactate and/or lemon Lemon acid calcium and/or casein calcium phosphate etc.；Phosphorus nourishing is mainly derived from calcium phosphate and/or casein calcium phosphate and/or phosphoric acid Potassium dihydrogen etc.；Potassium nutrition is mainly derived from potassium chloride and/or potassium citrate and/or potassium sulfate and/or potassium dihydrogen phosphate；Magnesium element Nutrition is mainly derived from magnesium carbonate and/or magnesium sulfate and/or magnesium chloride hexahydrate；Ferrite rolling technology be mainly derived from ferric phrophosphate and/ Or activated ferric oxide and/or ferric chloride and/or ferric citrate and/or ferrous sulfate；Zinc nutrition is mainly derived from seven water sulfur Acid zinc and/or zinc chloride and/or zinc lactate and/or zinc acetate；Iodine element nutrition be mainly derived from potassium iodide and/or sodium iodide and/ Or potassium iodate and/or potassium iodate；Selenium element nutrition is mainly derived from sodium selenide and/or sodium selenite pentahydrate；Copper element nutrition mainly comes Come from copper sulphate pentahydrate；Chromium element nutrition is mainly derived from nicotinic acid chromium and/or chromium glycine and/or Rich chromium yeast and/or three oxidations Chromium and/or chromous oxide and/or Chlorizate chromium；Manganese nutrition is mainly derived from manganese chloride tetrahydrate and/or manganese chloride.

Biotin (biotin) is for the heteroplasia of glycogen, the comprehensive function of fatty acid and some amino acid whose new old generation Thank, be all a crucial controlling element, and rush can be played by helping the synthesis to some protein that produces of energy Enter effect；Can grow, manufacture fatty acid, metabolism saccharide, fat and protein by helper cell simultaneously, and contribute to vitamin B group Utilization；Promote sweat gland, nervous tissue, bone marrow, the health of male gonad；Safeguard skin and the normal operation of hair and growth, Alleviate eczema, dermatitis symptom；Prevention poliosis and alopecia, contributes to treating bald；Relax myalgia；Melancholy, insomnia are truly had Necessarily benefit；Also participate in the metabolism of vitamin B12, folic acid, pantothenic acid；Promote urea synthesis and excretion；Improve the immune merit of human body Energy.

Carbohydrate and the metabolism of fat in molybdenum participant's body, promote to grow；The ferment in liver and kidney can also be promoted Element plays a role；Molybdenum also participates in composition and the metabolism of vitamin B12, can promote erythrocytic growth and maturation, can prevent anemia； Molybdenum is the composition part of 3 kinds of metallothioneins of mammal (yellow purine dehydrogenase aldehyde oxidase sulfide enzyme), at biological oxidation In reaction, molybdenum mainly plays Electron Transfer with the conversion between pentavalent and sexavalence molybdenum, with the Cellular respiration core egg in human body White metabolism has substantial connection；But molybdenum nutrition element is crossed and can be caused poisoning at most, easily suffer stroke knee varus osteoporosis rickets Sick osteomalacia sexual hypofunction diarrhoea depilation anemia etc..

Detailed description of the invention

Embodiment one

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 240mg, linoleic acid 1g, protein 15g, glutamine 1g, carbohydrate 45g, dietary fiber are (big Wheat dietary fiber) 3g, dehydroretinol 00 μ gRE, beta-carotene 80 μ g, vitamin D1 .5 μ g, vitamin E 3mg α-TE, vitamin K1 20 μ g, vitamin C 40mg, folic acid 65 μ g, nicotinic acid 3mg, pantothenic acid 1.5 μ g, vitamin B1 0.05mg, vitamin B2 0.05mg, vitamin B6 0.5mg, vitamin B12 0.6 μ g, biotin 10 μ g, sodium 300mg, potassium 450mg, chlorine 300mg, calcium 350mg, phosphorus 300mg, magnesium 60mg, ferrum 3mg, zinc 3mg, manganese 0.1mg, copper 0.01mg, iodine 38 μ g, selenium 14 μ g, chromium 15 μ g, molybdenum 8 μ g.

Embodiment two

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 260mg, linoleic acid 3g, protein 30g, glutamine 3g, carbohydrate 65g, dietary fiber (swallow Wheat dietary fiber) 10g, 3-Hydroxyretinol 00 μ gRE, beta-carotene 120 μ g, vitamin D 6 μ g, vitamin e1 0mg α-TE, dimension be raw Element K1 40 μ g, vitamin C 60mg, folic acid 82 μ g, nicotinic acid 9mg, pantothenic acid 6 μ g, vitamin B1 1.2mg, vitamin B2 1.2mg, Vitamin B6 3mg, vitamin B12 2 μ g, biotin 25 μ g, sodium 400mg, potassium 550mg, chlorine 400mg, Ca45 0mg, phosphorus 400mg, magnesium 100mg, ferrum 8mg, zinc 6mg, manganese 1.5mg, copper 0.4mg, iodine 60 μ g, selenium 22 μ g, chromium 25 μ g, molybdenum 16 μ g.

Embodiment three

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 240mg, linoleic acid 3g, protein 15g, glutamine 3g, carbohydrate 45-65g, dietary fiber (beans dietary fiber) 3g, 3-Hydroxyretinol 00 μ gRE, beta-carotene 80 μ g, vitamin D 6 μ g, vitamin E 3mg α-TE, dimension are raw Element K1 40 μ g, vitamin C 40mg, folic acid 82 μ g, nicotinic acid 3mg, pantothenic acid 6 μ g, vitamin B1 0.05mg, vitamin B2 1.2mg, vitamin B6 0.5mg, vitamin B12 2 μ g, biotin 10 μ g, sodium 400mg, potassium 450mg, chlorine 400mg, calcium 350mg, phosphorus 400mg, magnesium 60mg, ferrum 8mg, zinc 3mg, manganese 1.5mg, copper 0.01mg, iodine 60 μ g, selenium 14 μ g, chromium 25 μ g, molybdenum 8 μ g.

Embodiment four

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 245mg, linoleic acid 1g, protein 15g, glutamine 1g, carbohydrate 50g, dietary fiber are (recklessly Radix Raphani dietary fiber) 3g, dehydroretinol 20 μ gRE, beta-carotene 90 μ g, vitamin D1 .5 μ g, vitamin E 4mg α-TE, dimension be raw Element K1 25 μ g, vitamin C 45mg, folic acid 70 μ g, nicotinic acid 4mg, pantothenic acid 1.5 μ g, vitamin B1 0.1mg, vitamin B2 0.1mg, vitamin B6 0.5mg, vitamin B12 0.8 μ g, biotin 10 μ g, sodium 330mg, potassium 480mg, chlorine 330mg, calcium 370mg, P33 0mg, magnesium 65mg, ferrum 4mg, zinc 3mg, manganese 0.5mg, copper 0.15mg, iodine 38 μ g, selenium 18 μ g, chromium 16 μ g, molybdenum 8 μ g.

Embodiment five

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 265mg, linoleic acid 2g, protein 25g, glutamine 2g, carbohydrate 60g, dietary fiber (Citrus chachiensis Hort. Fructus Citri tangerinae dietary fiber) 7g, dehydroretinol 80 μ gRE, beta-carotene 110 μ g, vitamin D3 .5 μ g, vitamin E 4mg α-TE, dimension be raw Element K1 25 μ g, vitamin C 45mg, folic acid 70 μ g, nicotinic acid 4mg, pantothenic acid 1.5 μ g, vitamin B1 0.1mg, vitamin B2 0.1mg, vitamin B6 0.5mg, vitamin B12 0.8 μ g, biotin 10 μ g, sodium 330mg, potassium 480mg, chlorine 330mg, calcium 370mg, P33 0mg, magnesium 65mg, ferrum 4mg, zinc 3mg, manganese 0.5mg, copper 0.15mg, iodine 38 μ g, selenium 18 μ g, chromium 16 μ g, molybdenum 8 μ g.

Embodiment six

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 265mg, linoleic acid 2g, protein 25g, glutamine 2g, carbohydrate 60g, dietary fiber 7g, Dehydroretinol 80 μ gRE, beta-carotene 110 μ g, vitamin D3 .5 μ g, vitamin E 7mg α-TE, vitamin K1 35 μ g, dimension are raw Element C65mg, folic acid 80 μ g, nicotinic acid 6mg, pantothenic acid 4 μ g, vitamin B1 0.8mg, vitamin B2 0.8mg, vitamin B6 1.5mg, vitamin B12 1.5 μ g, biotin 20 μ g, sodium 380mg, potassium 520mg, chlorine 380mg, calcium 420mg, phosphorus 380mg, magnesium 90mg, ferrum 7mg, zinc 5.5mg, manganese 1.5mg, copper 0.3mg, iodine 50 μ g, selenium 25 μ g, chromium 20 μ g, molybdenum 14 μ g.

Embodiment seven

The fully nutrient preparation for equilibrated type enteral nutrition of the present embodiment, including following components:

Alpha-linolenic acid 245mg, linoleic acid 2g, protein 15g, glutamine 2g, carbohydrate 50g, dietary fiber 7g, Dehydroretinol 20 μ gRE, beta-carotene 110 μ g, vitamin D1 .5 μ g, vitamin E 7mg α-TE, vitamin K1 25 μ g, dimension are raw Element C65mg, folic acid 70 μ g, nicotinic acid 6mg, pantothenic acid 1.5 μ g, vitamin B1 0.8mg, vitamin B2 0.1mg, vitamin B6 1.5mg, vitamin B12 0.8 μ g, biotin 20 μ g, sodium 330mg, potassium 520mg, chlorine 330mg, calcium 420mg, P33 0mg, magnesium 90mg, ferrum 4mg, zinc 5.5mg, manganese 0.5mg, copper 0.3mg, iodine 38 μ g, selenium 25 μ g, chromium 16 μ g, molybdenum 8-14 μ g.

Embodiment eight

Fully nutrient preparation for equilibrated type enteral nutrition, it is characterised in that: include following components:

Alpha-linolenic acid 250mg, linoleic acid 1.5g, protein 18g, glutamine 1.5g, carbohydrate 57g, meals are fine Dimension 5g, dehydroretinol 50 μ gRE, beta-carotene 100 μ g, vitamin D2 .5 μ g, vitamin E 6mg α-TE, vitamin K1 30 μ g, Vitamin C 50mg, folic acid 75 μ g, nicotinic acid 5mg, pantothenic acid 2.5 μ g, vitamin B1 0.5mg, vitamin B2 0.5mg, vitamin B6 1mg, vitamin B12 1.2 μ g, biotin 15 μ g, sodium 350mg, potassium 500mg, chlorine 355mg, calcium 400mg, phosphorus 350mg, magnesium 80mg, ferrum 5mg, zinc 4.5mg, manganese 1mg, copper 0.25mg, iodine 45 μ g, selenium 18 μ g, chromium 20 μ g, molybdenum 12 μ g.The nutrition of this embodiment The harmony of element is optimal.

Combination point content in above-described embodiment is the content in every 100g fully nutrient preparation.

In above-described embodiment, the carrier that can accept in medical science or bromatology or health care conduct and learning can be added and make powder, water Agent, tablet, pill, granule, described carrier includes excipient, thickening agent, and various adjuvant, and described adjuvant includes manna Alcohol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, sulfydryl second Acid, methionine, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, carbonate, acetate, phosphate, hydrochloric acid, acetic acid, phosphoric acid, xylitol, Maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and Its derivant, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, Lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, carbonic acid Calcium, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, tristearin Acid calcium, magnesium stearate etc., sweeting agent, the material that essence etc. uses as food additive.

Experimental example:

Method: select 30 example aged severe patients to apply equilibrated type enteral nutrition preparation (fully nutrient) nutritional support treatment 1 Month, before and after nutritional support, survey the nutritive indexs such as total serum protein, albumin, prealbumin, hemoglobin, body weight, liver respectively The biochemical indicator such as renal function, blood glucose.Result patient's total serum protein, albumin, front after fully nutrient nutritional support treatment January The nutritive index such as albumin, body weight raises, and compares before treatment, and difference has a statistical significance (P ＜ 0.05), hepatic and renal function, The indexs such as blood glucose have no significant change (P ＞ 0.05).Conclusion equilibrated type enteral nutrition preparation (fully nutrient) can be effectively improved always The malnutrition situation of year patient with severe symptoms.

In inpatient, the especially bad incidence rate of critical patient Middle nutrition reaches 40%～60%^〔1〕.Reasonably nutritional support It it is one of important clinical treatment measure of critically ill patient.Enteral nutrition (enteral nutrition) meets physiological status, favorably In advantages such as maintenance gut muco-membranous barrier and immunologic function, few intercurrent diseases, the most it is widely used in clinic.Herein with balance Type enteral nutrition preparation (fully nutrient), as enteral nutritional prescription, observes its impact on Nutritional Status of Patients.

1, object of study

Select the PACHE that the section office such as I institute's Department of Aged, Neurology Department, ICU accepted for medical treatment between in January, 2012 in June, 2013 II scoring^[2]More than 15 points, 95 examples of the Grade One Nursing aged severe patient's row enteral nutrition that can not independently take food or take food little Supporting Therapy, male 62 example, women 33 example, age 61～84 years old, year mean age (69.6 ± 5.8).Wherein stubbornly refuse because of cerebral infarction Can independently enter trencherman 51 example, alzheimer disease can not independently be taken food 23 examples, 21 examples that appetite difference food-intake is on the low side.Selected patient row Except disease of immune system, diabetes, liver, the patient of kidney merit severely subnormal.

2, method

Using equilibrated type enteral nutrition preparation (fully nutrient) to be configured to intestinal nutrient solution, (every 100g seeks its fully nutrient Content): protein 18g, glutamine 1.5g, carbohydrate 57g, fat 11g, alpha-linolenic acid 250mg, linoleic acid 1.5g, Dietary fiber 5g, dehydroretinol 50 μ gRE, beta-carotene 100 μ g, vitamin D2 .5 μ g, vitamin E 6mg α-TE, vitamin K1 30 μ g, vitamin C 50mg, folic acid 75 μ g, nicotinic acid 5mg, pantothenic acid 2.5 μ g, vitamin B1 0.5mg, vitamin B2 0.5mg, dimension Raw element B6 1mg, vitamin B12 1.2 μ g, biotin 15 μ g, sodium 350mg, potassium 500mg, chlorine 355mg, calcium 400mg, phosphorus 350mg, magnesium 80mg, ferrum 5mg, zinc 4.5mg, manganese 1mg, copper 0.25mg, iodine 45 μ g, selenium 18 μ g, chromium 20 μ g, molybdenum 12 μ g.Every 100g Adding 350ml warm water to mix well, the intestinal nutrient solution of about 400ml, its energy concentration is 1kcal/ml, and every patient is all according to 25 ～the dosage of 30kcal/kg d gives nutritional solution.Patient starts after average 4.5 days after being admitted to hospital to make through tube feed or oral mode With intestinal nutrient solution, use incremental mode to give intestinal nutrient solution, by 100～200ml/ time, progressively increase to 200～300m/ time, 4-6 time/d；Wherein there is abdominal distention in 6 examples, are delayed by symptom after the regulation consumption of intestinal nutrient solution and concentration Solving, there is diarrhoea in 4 examples, add with remission after Smectite Powder, and none example patient exits this observation.

3, observation index

95 example patients before nutritional support and nutritional support after 1 month, survey respectively body weight, triceps brachii skinfold, on Arm flesh encloses, and the nutritive indexs such as total serum protein, albumin, prealbumin, hemoglobin are looked in blood drawing, and hepatic and renal function, blood glucose, gallbladder are solid The index such as alcohol, triglyceride, biochemical indicator Toshiba Corp's TBA-120FR full automatic biochemical apparatus detection.

4, statistical procedures

Carrying out data analysis with SPSS 13.0 statistical software, measurement data represents with mean ± standard deviation (X ± s), treatment Front and back comparing selection and join t inspection, P ＜ 0.05 is that difference is statistically significant.

Result

1, Anthropometry results contrast before and after nutritional support

After nutritional support treatment January, body weight, triceps brachii skinfold all have increase, have statistics than difference before treatment Meaning (P ＜ 0.05)；Arm muscle circumference slightly increases, front with treatment than no significant difference (P ＞ 0.05, table 1).

The change (x ± s) of Anthropometry before and after table 1 95 example patient's nutritional support

2, serum albumin and hemoglobin results contrast before and after nutritional support

After nutritional support treatment January, total serum protein, albumin, prealbumin all have increase, have than difference before treatment Statistical significance (P ＜ 0.05)；Hemoglobin slightly increases, front with treatment than no significant difference (P ＞ 0.05, table 2).

The change (g/L, x ± s) of serum albumin and hemoglobin before and after table 2 95 example patient's nutritional support

3, biochemical indicator results contrast before and after nutritional support

Blood glucose (GLU), blood urea nitrogen (BUN), creatinine (Cr), potassium (K), sodium (Na), third turn of ammonia of paddy after nutritional support treatment January Enzyme (ALT) is front with treatment than no significant difference (P ＞ 0.05, table 4).

The change (x ± s) of biochemical indicator before and after table 3 95 example patient's nutritional support

Note: GLU: blood glucose；BUN: blood urea nitrogen；Cr: creatinine；K: potassium；Na: sodium；ALT: glutamate pyruvate transaminase

Discuss

Aged severe patient is in stress state, and breaks down proteins strengthens, and old people's metabolic characteristic is that protein closes simultaneously Becoming to reduce, glucose metabolic rate declines, and catabolism of fat ability declines.Aged severe patient often merges Multiple organ diseases, Off feed, digestive juice secretion reduces, and gastrointestinal peristalsis reduces, therefore aged severe patient's Yi Fasheng malnutrition.Malnutrition can Causing degradation multiple complications under infection, resistance to occur, case fatality rate rises.In time, rationally, effective enteral nutrition is to improvement Entire patient's situation, improving treatment success rate has positive effect.EN support in early days have " inexpensive, easy, effective, In accordance with physiology " superiority.Enteral nutrition relatively parenteral nutrition meets physiology, and the nutrient substance trans-portal vein system of enteral nutrition is inhaled Receipts are transported to liver, and comparison operators closes physiological status, few to circulation interference, and the beneficially generation of visceral protein and regulation, and Contribute to safeguarding the integrity of intestinal mucosa 26S Proteasome Structure and Function, keep the normal growth of intestinal autochthonous flora, reduce intestinal bacteria and move Position and Enterogenous hypermetabolism, protect the improvement into patient with severe symptoms's nutritional status quickly.Meanwhile, it is low that enteral nutrition also has expense, Easily implement and nursing, the advantages such as severe complication is relatively fewer.The patient for restoration of gastrointestinal function is thought at present research, should Come into effect enteral nutrition as early as possible.The study show that, application equilibrated type enteral nutrition preparation (fully nutrient) Supporting Therapy future trouble Person's total serum protein, albumin and prealbumin are all significantly increased, and body weight and triceps brachii skinfold significantly increase Before height, with treatment more statistically significant than difference (P ＜ 0.05)；Arm muscle circumference and hemoglobin also have increased slightly, and illustrate through flat After the nutritional support of weighing apparatus type enteral nutrition preparation, the nutriture of aged severe patient is improved.This data is it is also shown that apply After intestinal nutrient solution Supporting Therapy January, the index such as aged severe patient's Liver and kidney function, blood glucose, triglyceride does not deteriorates, may Improving with patient's nutriture after nutritional support, each internal organs activity has enough energy, body important organ to obtain protecting relevant.Flat Weighing apparatus type enteral nutrition preparation (fully nutrient) is provided that required various nutrient substance, reasonable mixture ratio, carbon water in its energy source Compound accounts for 57%, protein accounts for 18%, fat accounts for 25%, and the various vitamin that need containing human body and mineral, meals Fiber, glutamine etc..In this research, 95 example patients all complete the treatment of 1 month by a definite date, and patient tolerability is preferable.Meals are fine Tieing up at colonic through intestinal bacteria zymolysis, produce the short-chain fatty acid being easier to be absorbed by, short-chain fatty acid is colon cell Main energy sources, to protection gut barrier, prevents bacterial translocation from playing an important role.In sum, to aged severe patient Row Enteral Nutritional Support is safe and effective, and equilibrated type enteral nutrition preparation (fully nutrient) can improve aged severe and suffer from The nutriture function of person, promotes the rehabilitation of patient.

Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, although with reference to relatively The present invention has been described in detail by good embodiment, it will be understood by those within the art that, can be to the skill of the present invention Art scheme is modified or equivalent, and without deviating from objective and the scope of technical solution of the present invention, it all should be contained at this In the middle of the right of invention.

Claims (6)

1. the fully nutrient preparation for equilibrated type enteral nutrition, it is characterised in that: include following components:

Alpha-linolenic acid 240-260mg, linoleic acid 1-3g, protein 15-30g, glutamine 1-3g, carbohydrate 45-65g, Dietary fiber 3-10g, dehydroretinol 00-300 μ gRE, beta-carotene 80-120 μ g, vitamin D1 .5-6 μ g, vitamin E 3- 10mg α-TE, vitamin K1 20-40 μ g, vitamin C 40-60mg, folic acid 65-82 μ g, nicotinic acid 3-9mg, pantothenic acid 1.5-6 μ g, dimension Raw element B1 0.05-1.2mg, vitamin B2 0.05-1.2mg, vitamin B6 0.5-3mg, vitamin B12 0.6-2 μ g, biology Element 10-25 μ g, sodium 300-400mg, potassium 450-550mg, chlorine 300-400mg, calcium 350-450mg, phosphorus 300-400mg, magnesium 60- 100mg, ferrum 3-8mg, zinc 3-6mg, manganese 0.1-1.5mg, copper 0.01-0.4mg, iodine 38-60 μ g, selenium 14-22 μ g, chromium 15-25 μ g, Molybdenum 8-16 μ g.

Fully nutrient preparation for equilibrated type enteral nutrition the most according to claim 1, it is characterised in that: include following Component:

Alpha-linolenic acid 245-265mg, linoleic acid 1-2g, protein 15-25g, glutamine 1-2g, carbohydrate 50-60g, Dietary fiber 3-7g, dehydroretinol 20-280 μ gRE, beta-carotene 90-110 μ g, vitamin D1 .5-3.5 μ g, vitamin E 4- 7mg α-TE, vitamin K1 25-35 μ g, vitamin C 45-65mg, folic acid 70-80 μ g, nicotinic acid 4-6mg, pantothenic acid 1.5-4 μ g, dimension Raw element B1 0.1-0.8mg, vitamin B2 0.1-0.8mg, vitamin B6 0.5-1.5mg, vitamin B12 0.8-1.5 μ g, life Thing element 10-20 μ g, sodium 330-380mg, potassium 480-520mg, chlorine 330-380mg, calcium 370-420mg, P33 0-380mg, magnesium 65- 90mg, ferrum 4-7mg, zinc 3-5.5mg, manganese 0.5-1.5mg, copper 0.15-0.3mg, iodine 38-50 μ g, selenium 18-25 μ g, chromium 16-20 μ G, molybdenum 8-14 μ g.

Fully nutrient preparation for equilibrated type enteral nutrition the most according to claim 2, it is characterised in that: include following Component:

Alpha-linolenic acid 250mg, linoleic acid 1.5g, protein 18g, glutamine 1.5g, carbohydrate 57g, dietary fiber 5g, Dehydroretinol 50 μ gRE, beta-carotene 100 μ g, vitamin D2 .5 μ g, vitamin E 6mg α-TE, vitamin K1 30 μ g, dimension are raw Element C50mg, folic acid 75 μ g, nicotinic acid 5mg, pantothenic acid 2.5 μ g, vitamin B1 0.5mg, vitamin B2 0.5mg, vitamin B6 1mg, vitamin B12 1.2 μ g, biotin 15 μ g, sodium 350mg, potassium 500mg, chlorine 355mg, calcium 400mg, phosphorus 350mg, magnesium 80mg, ferrum 5mg, zinc 4.5mg, manganese 1mg, copper 0.25mg, iodine 45 μ g, selenium 18 μ g, chromium 20 μ g, molybdenum 12 μ g.

4. according to the fully nutrient preparation for equilibrated type enteral nutrition described in right 1, it is characterised in that: described dietary fiber For the one in barley diet fiber, Herba bromi japonici dietary fiber, beans dietary fiber, Radix Dauci Sativae dietary fiber, Citrus dietary fiber or Multiple.

Fully nutrient preparation for equilibrated type enteral nutrition the most according to claim 1, it is characterised in that: doctor can be added Learn or in bromatology or health care conduct and learning, the carrier that can accept makes powder, water preparation, tablet, pill, granule.

6. the arbitrary described fully nutrient preparation for equilibrated type enteral nutrition of claim 1-5 keeps healthy in enteral nutrition Application in product, enteral nutrition food.