CN106061542A - Method for promoting penetration of beauty care ingredient into skin, and device for promoting penetration of beauty care ingredient into skin - Google Patents

Method for promoting penetration of beauty care ingredient into skin, and device for promoting penetration of beauty care ingredient into skin Download PDF

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Publication number
CN106061542A
CN106061542A CN201580008864.0A CN201580008864A CN106061542A CN 106061542 A CN106061542 A CN 106061542A CN 201580008864 A CN201580008864 A CN 201580008864A CN 106061542 A CN106061542 A CN 106061542A
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skin
cosmetic ingredient
beauty care
cutaneous permeation
care ingredient
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CN201580008864.0A
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斋藤绘美
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Sharp Corp
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Sharp Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/44Applying ionised fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method for promoting the penetration of a beauty care ingredient into skin, said method comprising bringing the beauty care ingredient into contact with skin and then irradiating the beauty care ingredient with positive ions and negative ions each bound to a water molecule, wherein the positive ions and the negative ions are generated by electric discharging in the atmosphere; and a device for promoting the penetration into skin, which is a device used for promoting the penetration of a beauty care ingredient into skin and is equipped with an ion generation unit and an air blowing unit, wherein the ion generation unit can generate positive ions and negative ions each bound to a water molecule by electric discharging in the atmosphere, and the air blowing unit is used for supplying the positive ions and the negative ions into skin with which a beauty care ingredient has been in contact. Thus, it becomes possible to provide a method and a device both of which enable the penetration of a beauty care ingredient into skin more simply compared with the conventional methods and devices.

Description

Promote that the Cosmetic Ingredient method to Cutaneous permeation and Cutaneous permeation promote device
Technical field
The Cosmetic Ingredient that the present invention relates to be comprised for promotion cosmetic etc. is to the technology of Cutaneous permeation.
Background technology
In the past, in order to play the effect of cosmetics etc. fully, it is desirable to make the Cosmetic Ingredient infiltration that cosmetics etc. are comprised Enter skin.As promoting the Cosmetic Ingredient method to Cutaneous permeation, be such as referred to as iontophoresis will use DC current real The method of the inside that the composition of existing ionizing penetrates to the skin by being energized skin is famous.
It addition, such as propose in JP 2001-497 publication (patent documentation 1) by using ultrasonic element to make Cosmetics become more meticulous, thus the method improving the composition infiltration to skin.
Prior art literature
Patent documentation
Patent documentation 1: JP 2001-497 publication
Summary of the invention
The problem that invention is to be solved
But, above-mentioned iontophoresis, osmotic effect is high, and on the other hand, its difficult problem is, exist in Cosmetic Ingredient is right The weak composition of electricity irritation was decomposed in the stage of ionizing, if be that infiltration is not clear when keeping the usefulness of composition Really.It addition, need to obtain effect to be energized skin about 5 minutes, therefore, its difficult problem is the cost time.
It addition, in the method described in above-mentioned patent documentation 1, although say that realization becomes more meticulous, but the size of particle and skin The gap of skin is compared very big, and permeability-enhancing effect is existed query.
The present invention completes to solve the problems referred to above, its object is to, it is provided that compared with the past can be more simply Make the method and apparatus that Cosmetic Ingredient penetrates into skin.
For solving the scheme of problem
The Cosmetic Ingredient that promotes of the present invention to the method for Cutaneous permeation is, after making Cosmetic Ingredient and contact skin, to this Cosmetic Ingredient irradiates the cation with water molecules and anion produced by the electric discharge in air.
It addition, the Cutaneous permeation that the present invention also provides for Cosmetic Ingredient promotes device, it is to promote that Cosmetic Ingredient is to skin The device that skin permeates and uses, possesses: ion generating portion, and it produces produced and water molecules by the electric discharge in air Cation and anion;And air supplying part, it for carrying above-mentioned cation and bearing to the skin contacting Cosmetic Ingredient Ion.
The most in the present invention, above-mentioned cation is H+(H2O)m(m is arbitrary natural number), above-mentioned anion is O2 - (H2O)n(n is arbitrary natural number).
Invention effect
According to the present invention, be provided that compared with the past can make Cosmetic Ingredient penetrate to the skin depths, improved looks fully The method of the usefulness of composition and the device of use the method.
Accompanying drawing explanation
Fig. 1 is for the device promoting Cosmetic Ingredient to be adapted in use in the method for Cutaneous permeation in the present invention is described Use the schematic diagram of the principle of the ion generation of ion generating device 60.
Fig. 2 is that (Cutaneous permeation of the present invention promotes device institute for the device that represents and possess the ion generating device 60 shown in Fig. 1 A preferred example (embodiment 1)) schematic diagram of overall outward appearance.
Fig. 3 is that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 71 (embodiment 2) The figure of outward appearance.
Fig. 4 is that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 71 (embodiment 2) The figure in cross section.
Fig. 5 is that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 120 (embodiment 3) The figure of outward appearance of face side.
Fig. 6 is that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 120 (embodiment 3) The figure of outward appearance of rear side.
Fig. 7 is the vertical profile side-looking of Cutaneous permeation promotion device 120 (embodiment 3) of another example preferred for this invention Figure.
Fig. 8 is the photo of the result representing experimental example 1, and Fig. 8 (a) represents embodiment 1, and Fig. 8 (b) represents comparative example 1, Fig. 8 C () represents comparative example 2.
Fig. 9 is the coordinate diagram of the result representing experimental example 2.
Detailed description of the invention
< Cosmetic Ingredient promotes method > to the infiltration of skin
The present invention promotes that Cosmetic Ingredient is characterised by the method for Cutaneous permeation, makes Cosmetic Ingredient and contact skin After, this Cosmetic Ingredient is irradiated the cation with water molecules produced by the electric discharge in air and anion.This Outward, the what is called in the present invention " Cosmetic Ingredient " refers to that such as ceramide, collagen, hyaluronic acid, ascorbic acid etc. have hydrophilic The composition of group, cosmetics, quasi drug, the medicine such as astringent, beautifying liquid, emulsion, facial cream comprised in order to beautify looks and The naturally occurring or synthetic chemical substance being coated on the skin of face etc..
Here, Fig. 1 is to be adapted in use in the method for Cutaneous permeation at the promotion Cosmetic Ingredient of the present invention for explanation The ion generation using ion generating device 60 of device (Cutaneous permeation of the aftermentioned present invention promotes the preferred example of device institute) The schematic diagram of principle, Fig. 2 is that (Cutaneous permeation of the present invention promotees for the device that represents and possess the ion generating device 60 shown in Fig. 1 Enter device a preferred example) schematic diagram of (embodiment 1) overall outward appearance.
Figure 2 illustrates the ion generator tool 6 of outward appearance in housing (casing), to possess ion shown in Fig. 1 unit occurs Part 60 is as ion generating portion.Ion generating device 60 has the voltage being connected with high-voltage generating device 4,5 and applies needle electrode 1、2;And apply, with above-mentioned voltage, ground connection (relative) electrode 3 that needle electrode 1,2 is adjacent to.Ground electrode 3 presses voltage The quantity applying needle electrode is equipped with the through hole 31 making voltage applying needle electrode 1,2 through.Voltage applies needle electrode 1,2 to be had The front end of needle-like, voltage applies needle electrode 1,2 and is configured to be connected and by high-voltage generating device with high-voltage generating device 4,5 4, being positioned at the center of the through hole 31 of ground electrode 3 under 5 states supported, needle-like front end is positioned at the ground electrode 3 of through hole 31 Thickness in the range of.
4,5 pairs of voltages of high-voltage generating device apply needle electrode 1,2 supply DC pulse voltage and make it discharge, and thus make Air ionization near ground electrode 3.Ion the opening from housing produced by the ion generating device 60 of ion generator tool 6 Mouth 61 is released.Further, the ion discharged is by that be disposed adjacent with ion generator tool 6, as the air-supply wind of air supplying part Fan 7 dissipates in air.
The principle that the ion of ion generating device 60 occurs is described.
Ion generating device 60 has the voltage being connected with high-voltage generating device 4 and applies pin electricity as ion generation electrode Pole 1 (cation generation electrode) and the voltage being connected with high-voltage generating device 5 apply needle electrode 2 (anion generation electrode). Above-mentioned voltage applies needle electrode 1 supply DC pulse voltage and apply positive voltage, on the other hand, voltage is applied needle electrode 2 supply DC pulse voltages and apply the voltage born.Made near cation generation electrode 1 and ground electrode 3 by corona discharge Positive aeroion, and make the negative aeroion near anion generation electrode 2 and ground electrode 3.
Additionally, adjust according to voltage, the pulse period of 4,5 pairs of voltages applying needle electrodes 1,2 applyings of high-voltage generating device The amount (concentration) of the ion that joint produces.
To the infiltration of skin, the Cosmetic Ingredient of the present invention promotes that method is by making after Cosmetic Ingredient and contact skin this U.S. Rongcheng is divided and irradiates the cation with water molecules and anion produced by the electric discharge in air, it is thus possible to make beauty treatment Composition penetrates into skin efficiently.In the present invention, it is preferred to cation is H+(H2O)m(m is arbitrary natural number), anion is O2 -(H2O)n(n is arbitrary natural number).
The most in the present invention, the cation produced by electric discharge and the concentration of anion are 7000/cm respectively3With On.Its reason is, the concentration at cation and anion is respectively smaller than 7000/cm3In the case of, exist and skin is supplemented water The inefficient tendency of the effect divided.Additionally, in this as the definition of amount of ions, with small ion as calculation and object, make For the critical degree of excursion in air, it is set to 1cm2/ V the second.
Think and promote that Cosmetic Ingredient skin permeation is brought by the following mechanism of action by the present invention: positive and negative two ions Moisture and contact skin also penetrate into skin, thus form the path of the Cosmetic Ingredient infiltration for having hydrophilic group.
The Cutaneous permeation of < Cosmetic Ingredient promotes device >
(embodiment 1)
It addition, the present invention is additionally provided in and is adapted in use in the Cutaneous permeation promotion method of the Cosmetic Ingredient of the invention described above Device.The Cutaneous permeation of the Cosmetic Ingredient of the present invention promotes that device possesses: ion generating portion, and it produces by the electric discharge in air And the cation with water molecules produced and anion;And air supplying part, it is for the skin contacting Cosmetic Ingredient Skin carries above-mentioned cation and anion.Specifically, with reference to Fig. 1, Fig. 2, (embodiment can be appropriately carried out by above-mentioned composition 1)。
(embodiment 2)
Fig. 3 and Fig. 4 is that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 71 (embodiment party Formula 2) figure, Fig. 3 represents that outward appearance, Fig. 4 represent cross section.Cutaneous permeation at the example shown in Fig. 3 and Fig. 4 promotes in device 71, In housing (casing) 72a, possesses the ion generating portion 77 with the ion generating device shown in Fig. 1 as ion generating portion. The ion produced by the ion generating device of ion generating portion 77 discharges from the opening (blow-off outlet) 76 of housing 72a.Such as Fig. 4 institute Showing, Cutaneous permeation promotes that device 71 possesses air supplying part 75 that is adjacent with ion generating portion 77 and that have Air Blast fan 78.At ion The cation and the anion that produce in generating unit 77 are dissipated in air by the Air Blast fan 78 of air supplying part 75.So constitute Cutaneous permeation promotes when device 71 such as uses in going to bed, can be without difficulty and for a long time to skin exposure ion.
Cutaneous permeation promote device 71 in order to ion generating portion 77 and air supplying part 75 being configured in going to bed suitable position, Preferably casing 72a and supporting part 74 are linked by the arm 73 that can freely regulate gradient.
It addition, Cutaneous permeation promotes that device 71 is in order to prevent skin within the period of medium long-time use of such as going to bed from doing Dry, the preferably air output of Air Blast fan 78 is little.
(embodiment 3)
Fig. 5, Fig. 6 and Fig. 7 are that the Cutaneous permeation schematically showing another example preferred for this invention promotes device 120 The figure of (embodiment 3), Fig. 5 is the outward appearance of face side, and Fig. 6 is the outward appearance of rear side, and Fig. 7 is that longitudinal cross-sectional side view is (except clip Portion).Cutaneous permeation shown in Fig. 5~Fig. 7 promotes that device 120 also possesses: ion generating portion, and it produces by the electric discharge in air And the cation with water molecules produced and anion;And air supplying part, it is for the skin contacting Cosmetic Ingredient Skin carries above-mentioned cation and anion, has and cation and anion is blown out to outside together with the air sucked from outside Function.Cutaneous permeation promotes that the profile of device 120 is prism-shaped, and e.g. height is the width of about 50mm, left and right directions For about 35mm, the small size that thickness is about 10mm of fore-and-aft direction, can be used for portable.
Cutaneous permeation promotes that device 120 possesses shell 121, circuit substrate 163, battery 164, sending as above-mentioned air supplying part Blower fan 165, ion generator 166, clip portion 122 and suspender belt 128 as above-mentioned ion generating portion.Shell 121 possesses: vertical Formula and the trunk 11 in rib tubular, the upper plate 132 of tabular of upper end of covering trunk 131, the lower end of covering trunk 131 The base plate 133 of tabular.The slightly lower part of the trunk 131 middle part in the left and right sides has suction inlet 131a.Upper plate 132 exists Front has blow-off outlet 132a, 132b.Base plate 133 is provided with the USB socket terminal for being connected with external power source and electricity Source button (omits diagram).
Illustrate that Cutaneous permeation promotes the Inner Constitution of the shell 121 of device 120.Circuit substrate 163 is configured at fore-and-aft direction Substantial middle.The most chargeable lithium ion battery of battery 164 etc., the rectangular tabular of profile.Battery 164 is configured at circuit The rear side of substrate 163.Pressure fan 165 is centrifugal fan, multiple blade 165a by motor 165b around fore-and-aft direction axle revolve Turn and drive.Pressure fan 165 separates the front side being configured at circuit substrate 163 with gap, this gap and the trunk being located at shell 121 The suction inlet 131a of 131 communicates, and constitutes upstream side circulation flow path 167a.
The blade 165a of pressure fan 165 rotates, and thus as shown in the hollow arrow of Fig. 7, air is from upstream side circulation flow path The inner space 167b of 167a suction draft machine 165, and from the top being located at pressure fan 165, Open Side Down trip effluent path 167c sends.The sparking electrode of ion generator 166 is exposed to downstream circulation flow path 167c.
Ion generator 166 is configured at the top of circuit substrate 163,2 sparking electrodes difference to ion generator 166 Apply the high voltage of negative polarity, the high voltage of positive polarity, thus produce cation and anion.Produced by ion generator 166 Cation and anion with in the circulation flow path 167c of downstream circulation air together with from blow-off outlet 132a, 132b blow out.
Hereinafter, the effect of the present invention is described according to experimental result.
< experimental example 1 >
Dimensional culture epidermis model (LabCyte EPI-about the people that stacking has been cultivated people's normal epidermis cell MODEL12, Tissue Engineering company of Japan system) carry out (a) applying cosmetic product after irradiated positive and negative the two of 6 hours from 6 hours wind (air-supply condition is same as in Example 1) has only been irradiated after son and the situation (embodiment 1) of wind, (b) applying cosmetic product Three examples of the situation (comparative example 2) that naturally placed 6 hours after situation (comparative example 1), (c) applying cosmetic product observe U.S. Rongcheng divides the level of interpenetration to skin.
Specifically, it is 24.5 ± 1 DEG C in room temperature, in the environment of humidity is 20 ± 2%, epidermis model is coated with 100 μ L Comprise fluorescent labeling ceramide C-12NBD-D-red-(C-12NBD ceramide, Cayman Chemical is public for sphingol Department's system) liquid after, cation and anion with the position of epidermis model respectively become 100000/cm3Ion concentration Mode adjust Cosmetic Ingredient Cutaneous permeation promote device (plasmoid head of a bed humidifier IB-BS12, Sharp Corporation System) ion generating portion and air supplying part being irradiated.Other gradation composition of cosmetics is set to cosmetics and typically can use Water, ethanol, glycerol, butanediol, PEG60 castor oil hydrogenated.By with the cross section of fluorescence microscope epidermis model thus Judge the level of interpenetration of fluorescence ceramide.
Fig. 8 is the photo of the result representing experimental example 1, and Fig. 8 (a) represents embodiment 1, and Fig. 8 (b) represents comparative example 1, Fig. 8 C () represents comparative example 2.According to Fig. 8 (a), it is known that (implement in the case of having irradiated positive and negative two ions and wind after applying cosmetic product Example 1), compared with only applying cosmetic product, the inside that fluorescence ceramide penetrates to the skin (is not only arrived horny layer surface and is also arrived granule Layer, have spinous layer).The situation (comparative example 1) of wind and the situation (comparative example 2) of only applying cosmetic product has only been irradiated after applying cosmetic product Identical, penetrate into horny layer surface, it may thus be appreciated that the effect of embodiment 1 is the effect of positive and negative two ions.
< experimental example 2 >
About having irradiated 2 hours positive and negative two ions and the situation (embodiment of wind after skin (a) applying cosmetic product to people 2) two of situation (comparative example 3) of 2 hours wind (air-supply condition is same as in Example 2), have only been irradiated after (b) applying cosmetic product Example determines the Cosmetic Ingredient infiltration capacity to skin.
Specifically, in the environment of room temperature is 21 DEG C and humidity is 39%~40%, square at the inner forearm 5cm of people In the range of be coated with 50 μ L coordinate ceramides astringent after, cation and anion with coating part respectively become 100000/cm3The mode of ion concentration adjust the Cutaneous permeation of Cosmetic Ingredient and promote device (plasmoid head of a bed humidifier IB-BS12, Sharp Corporation's system) ion generating portion and air supplying part being irradiated.Other gradation composition of cosmetics The water that is set in cosmetics typically to use, ethanol, glycerol, butanediol, PEG60 castor oil hydrogenated.With regard to ceramide to angle For the infiltration capacity of matter layer, peel skin surface (horny layer) with the adhesive tape of 2 × 5cm, right with HPLC (high performance liquid chromatography) Ceramide in the horny layer extracted has been carried out quantitatively.
Fig. 9 is the coordinate diagram of the result representing experimental example 2, and the longitudinal axis represents the ceramide amount (μ g/ml) detected, transverse axis Indicate without PCI (comparative example 3) respectively, have PCI (embodiment 2).According to the result shown in Fig. 9, shine after applying cosmetic product Having penetrated the ceramide amount detected in the situation (embodiment 2) of positive and negative two ions and wind is 3.160 μ g/ml, and in coatingization Only having irradiated the ceramide amount detected in the situation (comparative example 3) of 2 hours wind after cosmetic is 2.483 μ g/ml, in coatingization In the case of having irradiated positive and negative two ions and wind after cosmetic, in horny layer, the ceramide amount of infiltration is more.
According to above 2 experimental examples, by rear irradiation ions such as applying cosmetic products, thus compared with the past can carry The osmotic effect of high Cosmetic Ingredient.
Description of reference numerals
1 voltage applies needle electrode (cation generation electrode);2 voltages apply needle electrode (anion generation electrode);3 ground connection (relatively) electrode;4 high-voltage generating devices;5 high-voltage generating devices;6 ion generator tools;7 Air Blast fans;31 through holes; 60 ion generating devices;61 openings;71 Cutaneous permeation promote device;72a housing;73 arms;74 supporting parts;75 air supplying part;76 open Mouthful;77 ion generating portion;78 Air Blast fans;120 Cutaneous permeation promote device;121 shells;122 clip portions;128 suspender belts;131 Trunk;132 upper plates;132a, 132b blow-off outlet;133 base plates;163 circuit substrates;164 batteries;165 pressure fan;165a leaf Sheet;165b motor;166 ion generators;167a upstream side circulation flow path;167b inner space;167c downstream circulation flow path.

Claims (4)

1. one kind promotes the Cosmetic Ingredient method to Cutaneous permeation, it is characterised in that after making Cosmetic Ingredient and contact skin, right This Cosmetic Ingredient irradiates the cation with water molecules and anion produced by the electric discharge in air.
Promotion Cosmetic Ingredient the most according to claim 1 is to the method for Cutaneous permeation, it is characterised in that above-mentioned cation is H+(H2O)m(m is arbitrary natural number), above-mentioned anion is O2 -(H2O)n(n is arbitrary natural number).
3. the Cutaneous permeation of Cosmetic Ingredient promotes a device, is the dress in order to promote Cosmetic Ingredient to use to Cutaneous permeation Put, it is characterised in that possess:
Ion generating portion, it produces the cation with water molecules and anion produced by the electric discharge in air; And
Air supplying part, it is for carrying above-mentioned cation and anion to the skin contacting Cosmetic Ingredient.
The Cutaneous permeation of Cosmetic Ingredient the most according to claim 3 promotes device, it is characterised in that above-mentioned cation is H+ (H2O)m(m is arbitrary natural number), above-mentioned anion is O2 -(H2O)n(n is arbitrary natural number).
CN201580008864.0A 2014-04-10 2015-01-30 Method for promoting penetration of beauty care ingredient into skin, and device for promoting penetration of beauty care ingredient into skin Pending CN106061542A (en)

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JP2014-081071 2014-04-10
JP2014081071 2014-04-10
PCT/JP2015/052652 WO2015156017A1 (en) 2014-04-10 2015-01-30 Method for promoting penetration of beauty care ingredient into skin, and device for promoting penetration of beauty care ingredient into skin

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Application publication date: 20161026