CN106053198B - Agent liquid vortex oscillator and automatic analyzer - Google Patents
Agent liquid vortex oscillator and automatic analyzer Download PDFInfo
- Publication number
- CN106053198B CN106053198B CN201610490162.7A CN201610490162A CN106053198B CN 106053198 B CN106053198 B CN 106053198B CN 201610490162 A CN201610490162 A CN 201610490162A CN 106053198 B CN106053198 B CN 106053198B
- Authority
- CN
- China
- Prior art keywords
- turntable
- liquid
- dose
- support
- agent liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
The present invention relates to a kind of dose of liquid vortex oscillators, including pedestal；Rotating cylinder is mounted on the pedestal by centre rotational axis, and rotating cylinder eccentric setting on the end face opposite with the centre rotational axis has branch seat rotating axis；Support is shaken, it is rotatable to be set on the branch seat rotating axis, the fixation member for fixed reactor is provided on the concussion support；Rotation condition mechanism is fixedly connected with the concussion support, and when the drum rotation, the rotation for realizing around the branch seat rotating axis 360 ° in the same direction for limiting the concussion support can guarantee that agent liquid is more fully mixed with sample.The invention further relates to a kind of automatic analyzer including above-mentioned dose of liquid vortex oscillator, which can be accurately positioned the reactor after mixing.
Description
Technical field
The present invention relates to automatic analysis technology fields, more particularly to a kind of dose of liquid vortex oscillator and automatic analyzer.
Background technique
In vitro diagnosis etc. biochemical analysis technical field, toward reaction vessel additive liquid after carry out biochemical reaction, reacting
In the process, it needs to mix analysis agent liquid, it is allowed sufficiently to react.In general, automated analysis device has mixing dress
It sets.Relatively low field, such as biochemical analyser are required between dustiness mutual differential responses container, it is generally direct using stirring rod
Agent liquid is mixed, the cleaning of stirring rod is executed after mixing, then the agent liquid in next reaction vessel is mixed.
Harsh field, such as chemiluminescence or molecular diagnosis field are required dustiness mutual differential responses container, it is general to use
Contactless mixing carries out eccentric concussion to reaction vessel by mechanical structure, agent liquid is made to form homogeneous in reaction vessel
Liquid creates good conditions for sufficiently reaction.
But the reactor on the eccentric oscillator of tradition can only generate revolution with rotating cylinder, or in process of revolution arbitrarily
Rotation, or up-down vibration is generated while revolution, cause mixed effect bad, reaction solution is easy to splash out from reactor.
Summary of the invention
Based on this, it is necessary to provide a kind of agent liquid vortex oscillator for effectively improving mixed effect and there is the agent liquid whirlpool
Revolve the automatic analyzer of oscillator.
A kind of dose of liquid vortex oscillator, comprising:
Pedestal；
Rotating cylinder is mounted on the pedestal by centre rotational axis, and the rotating cylinder is opposite with the centre rotational axis
Eccentric setting has branch seat rotating axis on end face；
Support is shaken, it is rotatable to be set on the branch seat rotating axis, it is provided on the concussion support for fixing
The fixation member of reactor；
Rotation condition mechanism is fixedly connected, when the drum rotation, for preventing the concussion with the concussion support
Support realizes 360 ° of rotation around the branch seat rotating axis in the same direction.
The eccentric distance of the branch seat rotating axis and the centre rotational axis is X in one of the embodiments, wherein
0.5mm≤X≤5mm。
The rotating cylinder is connected with for controlling its control device started or stoped in one of the embodiments, described
Control device includes that controller, sensor and signal induce part, and the signal induces part and is fixedly connected with the rotating cylinder, described
Sensor is fixed on the pedestal and is electrically connected with the controller, wherein passes through the sensing when the signal induces part
When device, hopping edge signal will be generated, the hopping edge signal is fed back to the controller by the sensor.
The centre rotational axis is connected with the motor being mounted on the pedestal in one of the embodiments, described
Motor is under conditions of low-speed running, and the controller, which detects, stops the motor rotation when hopping edge signal,
The concussion support is set to stop at specified location.
It is provided with alarm on the controller in one of the embodiments, when the jump generated in the unit time
When becoming along the target value of the quantity deviation setting of signal, the alarm generates alarm.
It is with sensor matte jaggy that the signal, which induces part, in one of the embodiments, or is magnetic part,
Wherein, output hopping edge signal when the notch passes through the sensor.
The rotation condition mechanism includes first connecting rod and rocking bar in one of the embodiments, the first connecting rod
One end is fixedly connected with the concussion support, and the other end of the first connecting rod and the rocking bar are hinged, and the rocking bar is far from institute
The one end for stating first connecting rod is hinged on the pedestal.
The rotation condition mechanism includes second connecting rod and sliding block in one of the embodiments, the second connecting rod
One end is fixedly connected with the concussion support, and the other end of the second connecting rod and the sliding block are hinged, the sliding block with it is described
The sliding slot opened up on pedestal is adapted.
Provided by the invention dose of liquid vortex oscillator, due to being fixed with rotation condition mechanism, earthquake branch on concussion support
When seat is around centre rotational axis revolution, rotation condition mechanism drives angle of the concussion support along a direction rotation less than 360 °, when
When revolving to certain position, angle of the support by rotation in opposite direction less than 360 ° is shaken.Therefore, concussion support revolution
When, rotation not instead of always in the same direction, can generate periodic variation.The turbulent flow of agent liquid can be further increased in this way
Effect forms more powerful vortex, mixes agent liquid more fully with sample.
A kind of automatic analyzer, including for carrying and driving reactor with the incubation turntable that rotates with it, for carrying
And transfer agent liquid is filled to the agent liquid device for being incubated for turntable for carrying and shifting sample to the sample for being incubated for turntable
It sets, measuring device, controller；Described dose of liquid device, sampling device and measuring device are in the circumferential around the incubation turntable
Arrangement, which is characterized in that also arrange around the incubation turntable such as any of the above-described agent liquid vortex oscillator；It is described to incubate
Turntable, agent liquid device, sampling device, measuring device, agent liquid vortex oscillator is educated to be electrically connected with the controller.
Described dose of liquid device includes agent liquid turntable and agent liquid transfer assembly in one of the embodiments, and described dose of liquid turns
It moves component to be arranged between the incubation turntable and agent liquid turntable, described dose of liquid turntable has been arranged circumferentially several doses of liquid along it
Hold position；The sampling device includes sample turntable and sample transfer assembly, and the sample transfer assembly is arranged in the incubation
Between turntable and sample turntable, if the sample turntable has been arranged circumferentially dry-eye disease along it and has held position；Described dose of liquid is vortexed
Reactor transfer assembly is provided between oscillator and incubation turntable.
Automatic analyzer provided by the invention, automatic analyzer are real to agent liquid and sample using above-mentioned dose of liquid vortex oscillator
Now it is sufficiently mixed, meanwhile, when agent liquid vortex oscillator stops working, it is specified required that controller can be such that reactor is parked in
Position, reactor are able to achieve precise positioning, it is ensured that reactor transfer assembly very easily finished mixing in specified location
Reactor, which is transferred to, to be incubated in turntable.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of an embodiment agent liquid vortex oscillator；
Fig. 2 is the structural schematic diagram of another embodiment agent liquid vortex oscillator；
Fig. 3 is the partial structural diagram of agent liquid vortex oscillator；
Fig. 4 is the periodical excitation schematic diagram of hopping edge signal；
Fig. 5 is the structural schematic diagram of automatic analyzer；
Fig. 6 is the work flow diagram of agent liquid vortex oscillator.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
Add thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.Term as used herein "inner", "outside", "left", "right" and
Similar statement for illustrative purposes only, is not meant to be the only embodiment.
Simultaneously refering to fig. 1 to Fig. 3, a kind of dose of liquid vortex oscillator 10, including pedestal 100, rotating cylinder 200 shakes support 300
With rotation condition mechanism 400.It is fixedly connected with centre rotational axis 210 on one end face of rotating cylinder 200, centre rotational axis 210
The center line of axis and rotating cylinder 200 is completely coincident.Centre rotational axis 210 is mounted on pedestal 100, to reduce abrasion and guaranteeing to turn
The rotating accuracy of cylinder 200, can be set rolling bearing, such as ball bearing etc. between centre rotational axis 210 and pedestal 100.Turn
On another end face of cylinder 200, that is, branch seat rotating axis 220, support are provided on the end face opposite with centre rotational axis 210
Rotary shaft 220 and centre rotational axis 210 keep certain eccentric distance.Concussion support is rotatably equipped on branch seat rotating axis 220
300, concussion support 300 may be set to be cylindrical shape, and the top of concussion support 300 is provided with the fixed part of fixed reactor
Part.The bottom of concussion support 300 is fixedly connected with rotation condition mechanism 400.
The eccentric distance of branch seat rotating axis 220 and centre rotational axis 210 is X, and centre rotational axis 210 drives rotating cylinder 200 to revolve
Turn, due to the presence of eccentricity, branch seat rotating axis 220 is rotated around centre rotational axis 210, that is, around the center line of rotating cylinder 200
Rotation, thus can make branch seat rotating axis 220 that concussion support 300 be driven to generate revolution around centre rotational axis 210, it is suitable to guarantee
Revolution speed, eccentric distance X cannot be excessively high and too low, the value range of X are as follows: 0.5mm≤X≤5mm, it is preferred that the value of X is
3mm。
Refering to fig. 1, specifically, in one embodiment, rotation condition mechanism 400 includes first connecting rod 410 and rocking bar 420,
One end of first connecting rod 410 is fixedly connected with the bottom end of concussion support 300, the other end of first connecting rod 410 and the one of rocking bar 420
End is hinged, and rocking bar 420 is hinged on pedestal 100 far from one end of first connecting rod 410.First connecting rod 410, rocking bar 420 and rotating cylinder
200 constitute crank and rocker mechanism.
Referring to Fig.2, in another embodiment, rotation condition mechanism 400 includes second connecting rod 430 and sliding block 440, second connects
One end of bar 430 is fixedly connected with the bottom end of concussion support 300, and the other end and sliding block 440 of second connecting rod 430 are hinged, sliding block
440 are adapted with the sliding slot opened up on pedestal 100.Second connecting rod 430, sliding block 440 and rotating cylinder 200 constitute crank block machine
Structure.
It is connected with refering to fig. 1 with Fig. 5, rotating cylinder 200 for controlling its control device started or stoped, passes through control device
Effect, can detecte the revolving speed of rotating cylinder 200；It can also stop the rotation of rotating cylinder 200 in sometime point, to make concussion branch
Seat 300 is accurately parked in required position, and reactor is facilitated to take away from concussion support 300.Control device includes control
Device 12, sensor 510 and signal induce part.Signal induces the bottom that part is fixed on rotating cylinder 200, naturally it is also possible to be fixed on and turn
The middle part or top of cylinder 200, sensor 510 are fixed on pedestal 100 and are electrically connected with controller 12, sensor 510 and signal
It is corresponding to induce part, when rotating cylinder 200 rotates and signal is driven to induce part by sensor 510, hopping edge signal will be generated
530, hopping edge signal 530 is fed back to controller 12 by sensor 510.Controller 12 is controlled according to hopping edge signal 530 to be turned
When the operating of cylinder 200, i.e. control rotating cylinder 200 stop, so that concussion support 300 is in suitable position.Signal induces
Part is the sensor matte 520 with jagged 521, or is magnetic part.
When sensor 510 is using optocoupler sensor, optocoupler sensor is fixed at a certain position of pedestal 100, therewith
It is the sensor matte 520 with jagged 521 that corresponding signal, which induces part, and sensor matte 520 is rotated with rotating cylinder 200, when
When the optocoupler sensor of every process of notch 521, a hopping edge signal 530 will be inspired.When sensor 510 is passed using Hall
When sensor, it is magnetic part that signal, which induces part, and magnetic part can choose as magnet, and magnet is fixed on the outer wall of rotating cylinder 200, Hall
Sensor is fixed on a certain position of pedestal 100, and near the motion profile in magnet, when magnet is close to Hall sensor,
A hopping edge signal 530 can equally be excited.
Specifically, the fixation member of concussion support 300 preferably shakes hole 310, concussion hole 310 is outer with reactor bottom
Shape is adapted, and concussion hole 310 has reasonable depth.When reactor is cylindricality test tube, it is anti-that concussion hole 310, which is a circular hole,
Opposite concussion hole 310 generates unnecessary shaking when only reactor rotates, and shaking to increase on the inner wall in hole 310 has anti-slip layer, prevents
Slip layer can suitably increase reactor and shake the frictional force between hole 310.Certainly, fixation member also has other alternatives, example
For example a fixture or adhesive, as long as can make on the fixed earthquake support 300 of reactor, and very easily from concussion branch
It is removed on seat 300.
Refering to Fig. 3, motor 250 is installed on pedestal 100, the output shaft of motor 250 is connect with centre rotational axis 210, horse
Up to 250 to drive rotating cylinder 200 to rotate, to make rotating cylinder 200 keep higher revolving speed, motor 250 uses direct current generator, and revolving speed is
3000rpm.In the present embodiment, preferably high-speed stepper motor.It is appreciated that common stepper motor can also be used, general
Big belt wheel 240 is set on the output shaft of logical stepper motor, and small pulley 230 is installed on centre rotational axis 210, small pulley 230
By synchronous band connection between big belt wheel 240, common stepper motor driving rotating cylinder 200 may be implemented equally with higher speed
Rotation.
When motor 250 drives rotating cylinder 200 to rotate by centre rotational axis 210, branch seat rotating axis 220 drives concussion support
300 generate revolution around centre rotational axis 210, and under the action of revolution speed, agent liquid will form turbulent flow in the reactor, to produce
The raw concussion that is vortexed, the agent liquid in reactor is uniformly mixed with sample.Shake support 300 along a direction (such as counterclockwise or
While generating revolution clockwise), under the action of rotation condition mechanism 400, concussion support 300 is produced around branch seat rotating axis 220
It is born from and turns.No matter support can be revolved specifically, rotation condition mechanism 400 is crank and rocker mechanism or slider-crank mechanism
Line between the center and branch seat rotating axis 220 of 200 end face of rotating cylinder locating for shaft 220 regards a crank, branch seat rotating axis as
220 be the articulated shaft of the crank and first connecting rod 410 or second connecting rod 430, when rotation condition mechanism 400 operates, first
Connecting rod 410 or 430 relative seat rotary shaft 220 (being equivalent to articulated shaft) of second connecting rod will generate regular rotation, due to
One end of one connecting rod 410 or second connecting rod 430 is fixedly connected with concussion support 300, and concussion support 300 also can relative seat rotation
Shaft 220 will generate regular rotation, the i.e. rotation of relative seat rotary shaft 220.
Due to the distinctive characteristics of motion of rotation condition mechanism 400 itself, rotation condition mechanism 400 will limit concussion support
300 realize 360 ° of rotation in the same direction, that is to say, that when concussion support 300 revolves, rotation condition mechanism 400 drives shake
Swing support 300 along a direction (such as counterclockwise or clockwise) angle of the rotation less than 360 °, when revolution is to certain position,
Shake angle of the support 300 by rotation in opposite direction less than 360 °.Therefore, when concussion support 300 revolves, rotation is not
Always in the same direction, but periodic variation can be generated.When the direction of rotation generates cyclically-varying, can further mention
The turbulent flow effect of high agent liquid forms more powerful vortex, mixes agent liquid more fully with sample.
Refering to Fig. 4, when rotating cylinder 200 rotates, the notch 521 or magnet on sensor matte 520 into when crossing sensor 510,
A hopping edge signal 530 can be excited, controller 12 receives the hopping edge signal 530 by sensor 510, and controller 12 can be with
The revolving speed of rotating cylinder 200 is determined according to hopping edge signal 530, to ensure that agent liquid vortex oscillator 110 works normally, to agent liquid and
Sample, which plays, is sufficiently mixed uniform effect.200 high speed rotation of rotating cylinder, can generate multiple hopping edge signals 530, and controller 12 is examined
Measure the time interval T between two neighboring hopping edge signal 530, it can the revolving speed for finding out rotating cylinder 200 is 1/T, to reduce
Measurement error, can test the time interval of multiple hopping edge signals 530 of continuous adjacent, then be averaged to it, Ji Kezhun
The really revolving speed of measurement rotating cylinder 200, to realize controller 12 to the supervisory function bit of 200 speed of rotating cylinder.The revolving speed of rotating cylinder 200 can also
It is measured with the quantity by hopping edge generated in unit time signal 530, such as measuring revolving speed, with rotating speed of target there are larger
When gap, i.e. controller detect that the quantity for generating hopping edge signal 530 in the unit time deviates the target value of setting, then it is considered as
Abnormal conditions, due to being provided with alarm on controller, alarm will generate alarm, while controller 12 stops rotating cylinder 200
Rotation；Or controller 12 issues the revolving speed that rotating cylinder 200 is readjusted in instruction, is close to normal rotating speed of target.
If the revolving speed of rotating cylinder 200 is normal, controller 12 will control the rotation time of rotating cylinder 200, determine at what
When stop rotating cylinder 200 rotate, make shake support 300 be parked in designated position, thus be convenient to concussion support 300 on pick and place reaction
Device.In general, sensor 510 is placed on pedestal 100 and designated position corresponding position, when rotating cylinder 200 does not rotate, sensor
Notch 521 or magnet on matte 520 is just corresponding with sensor 510, in this way, when the concussion revolution of support 300 is by specified
When position, a hopping edge signal 530 can be excited.After reaching the concussion time, stop motor 250 and rotate, concussion support 300 will
It is parked in specified location.Specifically, the judgment mode of concussion time can be judged using the number of hopping edge signal 530,
Such as shaking the time is 10s, and the revolving speed of rotating cylinder 200 is 3000rph, then when controller 12 detects the 500th hopping edge signal 530
When, it can control the stopping of motor 250, rotating cylinder 200 stops operating, and concussion support 300 will be parked in designated position.
When controller 12 controls the stopping of motor 250, since motor 250 runs at high speed, there can be inertia, shake support
300 will stop in the place for deviateing designated position, be unfavorable for shaking the positioning of support 300 and the pick-and-place of reactor.It therefore, can be with
After the motor 250 to run at high speed stops, then low rate start motor 250 again, as long as controller 12 detects hopping edge signal
530, indicate that concussion support 300 just past designated position, stops operating, due to horse at this point, controller 12 controls motor 250
It stops operating at low speeds up to 250, it can be to avoid the effect of inertia, so that rotating cylinder 200 is immediately when stopping motor 250
It stops operating, concussion support 300 can stop in specified location, it is ensured that it is accurately positioned.It will be appreciated, of course, that working as motor 250
When can stop under deceleration regime, it also may not need and concussion support 300 positioned by two steps, i.e., it is low in motor 250
In the state of speed operating, when controller 12 detects the last one hopping edge signal 530, stop motor 250, it so also can be quasi-
Determine that support 300 is shaken in position.
Refering to Fig. 5, the present invention also provides a kind of automatic analyzers, including are incubated for turntable 600, agent liquid device 700, sample dress
Set 800, measuring device 900, controller 12 and agent liquid vortex oscillator 10 described above.Agent liquid device 700, sampling device
800, agent liquid vortex oscillator 10 and measuring device 900 are arranged around incubation turntable 600 in the circumferential.It is incubated for turntable 600, agent liquid
Device 700, sampling device 800, agent liquid vortex oscillator 10 and measuring device 900 are electrically connected with controller 12.
Turntable 600 is incubated for for carrying and driving reactor with rotating with it, turntable 600 is incubated for and is arranged circumferentially along it
There are several reactors to hold position 610, being incubated for turntable 600 can be around itself center axis rotation.
For carrying simultaneously transfer agent liquid, to incubation turntable 600, agent liquid device 700 includes agent liquid turntable 710 to agent liquid device 700
With agent liquid transfer assembly, the setting of agent liquid transfer assembly is being incubated between turntable 600 and agent liquid turntable 710, agent liquid transfer assembly packet
Include agent liquid probe 720 and with 720 matched doses of liquid service sinks 730 of agent liquid probe.Agent liquid turntable 710 is along its circumferential uniform cloth
It is equipped with several doses of liquid and holds position 711, agent liquid, which is held, can contain different types of dose of liquid in position 711, agent liquid turntable 710 can enclose
Around the central axis rotation of its own, when turning to makes certain one liquid hold position 711 and be incubated for nearest at a distance from turntable 600, agent
Liquid probe 720 will hold in position 711 from the agent liquid and draw in the reactor that agent liquid is put on incubation turntable 600, to prevent difference
It is mutually polluted between agent liquid, agent liquid probe 720 is every have been drawn after a kind of dose of liquid is put into reactor, it is necessary in agent liquid service sink
730 are cleaned, to draw down a kind of different agent liquid.
For sampling device 800 for carrying and shifting sample to turntable 600 is incubated for, sample transfer assembly includes sample probe
830 and sample clean matched with sample probe 830 pond 820.If sample turntable 810 has been arranged circumferentially dry sample along it
Product hold position 811, and sample, which is held, can contain different types of sample in position 811, and sample turntable 810 can surround its own
Central axis rotation, when turning to makes certain a sample hold position 811 and be incubated for nearest at a distance from turntable 600, sample probe 830 will
It holds pipette samples in position 811 from the sample to be put into the reactor being incubated on turntable 600, to prevent between different samples mutually
Pollution, sample probe 830 is every have been drawn after a kind of sample is put into reactor, it is necessary to it is cleaned in sample clean pond 820, with
Just a kind of different sample under drawing.
Reactor transfer assembly 11, reactor transfer group are provided between agent liquid vortex oscillator 10 and incubation turntable 600
The reactor being incubated on turntable 600 can be transferred on the concussion support 300 on agent liquid vortex oscillator 10 by part 11, so as to complete
It is mixed at sample with the uniform of agent liquid, after mixing, reactor transfer assembly 11 turns the reactor on support 300 is shaken
It moves to and is incubated on turntable 600.
Measuring device 900 detects the extent of reaction of sample in reactor and agent liquid, and will test information input control
Device 12 processed, controller 12 carry out the final analysis in relation to component content to detection information.
When automatic analyzer works, firstly, agent liquid probe 720 draws the agent liquid on agent liquid turntable 710, incubation is put it into
In reactor on turntable 600, it is incubated for turntable 600 and rotates and the reactor equipped with agent liquid is driven to turn to closest to sample turntable
When 810 position, it is incubated for turntable 600 and stops operating.Secondly, the sample on 830 pipette samples turntable 810 of sample probe, is put
Enter to be incubated in the reactor on turntable 600 equipped with agent liquid.Again, it is incubated for turntable 600 and drives the reactor that sample and agent liquid are housed
It turns near agent liquid vortex oscillator 10, which is transferred to agent liquid vortex oscillator 10 by reactor transfer assembly 11,
Sample and agent liquid are sufficiently mixed by agent liquid vortex oscillator 10 by the concussion that is vortexed, after mixing, 12 controlling agent liquid of controller
Vortex oscillator 10 at a time stops, and reactor is made accurately to be parked in designated position, facilitates reactor transfer assembly 11 will
The reactor mixed, which is transferred to, is incubated for turntable 600, through abundant incubation after a period of time.It is driven finally, being incubated for turntable 600
The reactor that incubation reaction is completed turns at measuring device 900, and measuring device 900 will complete the analysis of component content.
Refering to Fig. 6, for the workflow of agent liquid vortex oscillator 10, specifically, reactor transfer assembly 11 is anti-by this
Answer device be put into concussion hole 310 in, motor 250 drive rotating cylinder 200 rotation in reactor agent liquid and sample mix,
It shakes in mixed process, if controller 12 detects the revolving speed of rotating cylinder 200, there are abnormal conditions, generate alarm；If shake
It swings and has timed out, then stop motor 250.For the inertia for overcoming motor 250 to generate when stopping, reactor is made to be parked in specific bit
It sets, reactor transfer assembly 11 is facilitated to be transferred to be incubated for reactor in turntable 600 and be incubated for, it can low rate start horse again
Up to 250, after controller 12 detects hopping edge signal 530, stop motor 250 at this time, it in this way can be to reactor
Stand, which is realized, to be accurately positioned, it is ensured that reactor transfer assembly 11 can be in specified location shift reactor.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of dose of liquid vortex oscillator characterized by comprising
Pedestal；
Rotating cylinder is mounted on the pedestal by centre rotational axis, and the rotating cylinder is in the end face opposite with the centre rotational axis
Upper eccentric setting has branch seat rotating axis；
Support is shaken, it is rotatable to be set on the branch seat rotating axis, it is provided on the concussion support for fixed reaction
The fixation member of device；
Rotation condition mechanism is fixedly connected with the concussion support, when the drum rotation, for preventing the concussion support
Realize 360 ° of rotation in the same direction around the branch seat rotating axis；
Control device, connect with the rotating cylinder and is used to control rotating cylinder and start or stop, and the control device includes controller；
The rotation condition mechanism includes first connecting rod and rocking bar, and one end of the first connecting rod and the concussion support, which are fixed, to be connected
It connects, the other end of the first connecting rod and the rocking bar are hinged, and the rocking bar is hinged on institute far from one end of the first connecting rod
It states on pedestal.
2. according to claim 1 dose of liquid vortex oscillator, which is characterized in that the branch seat rotating axis and the center are revolved
The eccentric distance of shaft is X, wherein 0.5mm≤X≤5mm.
3. according to claim 1 dose of liquid vortex oscillator, which is characterized in that the control device further include sensor with
And signal induces part, the signal induces part and is fixedly connected with the rotating cylinder, the sensor be fixed on the pedestal and with
The controller electrical connection, wherein when the signal, which induces part, passes through the sensor, hopping edge signal will be generated, it is described
The hopping edge signal is fed back to the controller by sensor.
4. according to claim 3 dose of liquid vortex oscillator, which is characterized in that the centre rotational axis, which is connected with, to be mounted on
Motor on the pedestal, under conditions of the motor is in low-speed running, the controller detects the hopping edge letter
Number when stop motor rotation, so that the concussion support is stopped at specified location.
5. according to claim 3 dose of liquid vortex oscillator, which is characterized in that it is provided with alarm on the controller,
When the quantity of the hopping edge signal generated in the unit time deviates the target value of setting, the alarm generates alarm.
6. according to claim 3 dose of liquid vortex oscillator, which is characterized in that it is with jaggy that the signal, which induces part,
Sensor matte, or be magnetic part, wherein output hopping edge signal when the notch passes through the sensor.
7. a kind of dose of liquid vortex oscillator characterized by comprising
Pedestal；
Rotating cylinder is mounted on the pedestal by centre rotational axis, and the rotating cylinder is in the end face opposite with the centre rotational axis
Upper eccentric setting has branch seat rotating axis；
Support is shaken, it is rotatable to be set on the branch seat rotating axis, it is provided on the concussion support for fixed reaction
The fixation member of device；
Rotation condition mechanism is fixedly connected with the concussion support, when the drum rotation, for preventing the concussion support
Realize 360 ° of rotation in the same direction around the branch seat rotating axis；
Control device, connect with the rotating cylinder and is used to control rotating cylinder and start or stop, and the control device includes controller；
The rotation condition mechanism includes second connecting rod and sliding block, and one end of the second connecting rod and the concussion support, which are fixed, to be connected
It connects, the other end of the second connecting rod and the sliding block are hinged, and the sliding slot opened up on the sliding block and the pedestal is adapted.
8. a kind of automatic analyzer, comprising: for carrying and driving reactor with the incubation turntable rotated with it, be used to carry simultaneously
Transfer agent liquid to it is described be incubated for turntable agent liquid device, for carry and shift sample to it is described be incubated for turntable sampling device,
Measuring device；Described dose of liquid device, sampling device and measuring device are in the circumferential around incubation turntable arrangement, feature
It is, also arranges the agent liquid vortex oscillator as described in any in claim 1 to 7 around the incubation turntable；It is described to incubate
Turntable, agent liquid device, sampling device, measuring device is educated to be electrically connected with the controller.
9. automatic analyzer according to claim 8, which is characterized in that described dose of liquid device includes agent liquid turntable and agent liquid
Transfer assembly, described dose of liquid transfer assembly are arranged between the incubation turntable and agent liquid turntable, and described dose of liquid turntable is along its week
Position is held to several doses of liquid have been evenly arranged；The sampling device includes sample turntable and sample transfer assembly, and the sample turns
It moves component to be arranged between the incubation turntable and sample turntable, if the sample turntable has been arranged circumferentially dry-eye disease along it
Hold position；Reactor transfer assembly is provided between described dose of liquid vortex oscillator and incubation turntable.
10. automatic analyzer according to claim 9, which is characterized in that the reactor transfer assembly is used for will be described
The reactor being incubated on turntable is transferred on the concussion support on described dose of liquid vortex oscillator, is finished when sample is mixed with agent liquid
Afterwards, the reactor on the concussion support is transferred on the incubation turntable by the reactor transfer assembly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610490162.7A CN106053198B (en) | 2016-06-28 | 2016-06-28 | Agent liquid vortex oscillator and automatic analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610490162.7A CN106053198B (en) | 2016-06-28 | 2016-06-28 | Agent liquid vortex oscillator and automatic analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106053198A CN106053198A (en) | 2016-10-26 |
| CN106053198B true CN106053198B (en) | 2019-06-25 |
Family
ID=57165997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610490162.7A Active CN106053198B (en) | 2016-06-28 | 2016-06-28 | Agent liquid vortex oscillator and automatic analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106053198B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107219113B (en) * | 2017-07-23 | 2019-09-20 | 蒋春云 | A kind of multitube oscillation blending device applied in AIDS detection test |
| CN107254405A (en) * | 2017-08-03 | 2017-10-17 | 长春理工大学 | Fungal infection automatic tester |
| CN109991049B (en) * | 2017-12-29 | 2024-03-01 | 同方威视技术股份有限公司 | Pretreatment device and pretreatment method for food safety detection |
| CN108956255A (en) * | 2018-02-12 | 2018-12-07 | 宁波美康盛德生物科技有限公司 | Circulation formula mixing mechanism and its control method and its repositioning method |
| CN110354735A (en) * | 2019-07-30 | 2019-10-22 | 上海汇像信息技术有限公司 | Shaking table device and its shake localization method |
| CN111854656B (en) * | 2020-06-22 | 2021-08-20 | 深圳市铭特科技有限公司 | Accurate positioning method and system based on heavy-load turntable |
| CN111690515A (en) * | 2020-07-28 | 2020-09-22 | 北京擎科生物科技有限公司 | Oscillation device and equipment comprising same |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061267A (en) * | 1991-11-22 | 1992-05-20 | 浙江大学 | Positive and negative rotation hold concurrently reciprocating device and stirrer |
| CN2218022Y (en) * | 1994-08-30 | 1996-01-24 | 阿布卡西姆·阿汗麦德 | Electric mixer |
| EP1614471B1 (en) * | 1998-05-01 | 2010-08-04 | Gen-Probe Incorporated | Transport mechanism for automatic analyser |
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| JP2014126415A (en) * | 2012-12-26 | 2014-07-07 | Hitachi High-Technologies Corp | Automatic analyzer |
| CN103913584A (en) * | 2013-12-20 | 2014-07-09 | 东软安德医疗科技有限公司 | Full-automatic biochemical analyzer and stirring device thereof |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
| CN104722232A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Rotational vibration disc |
| CN205120452U (en) * | 2015-10-27 | 2016-03-30 | 山东省科学院海洋仪器仪表研究所 | Organic pollutant enrichment device in sea water |
-
2016
- 2016-06-28 CN CN201610490162.7A patent/CN106053198B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061267A (en) * | 1991-11-22 | 1992-05-20 | 浙江大学 | Positive and negative rotation hold concurrently reciprocating device and stirrer |
| CN2218022Y (en) * | 1994-08-30 | 1996-01-24 | 阿布卡西姆·阿汗麦德 | Electric mixer |
| EP1614471B1 (en) * | 1998-05-01 | 2010-08-04 | Gen-Probe Incorporated | Transport mechanism for automatic analyser |
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| JP2014126415A (en) * | 2012-12-26 | 2014-07-07 | Hitachi High-Technologies Corp | Automatic analyzer |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
| CN103913584A (en) * | 2013-12-20 | 2014-07-09 | 东软安德医疗科技有限公司 | Full-automatic biochemical analyzer and stirring device thereof |
| CN104722232A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Rotational vibration disc |
| CN205120452U (en) * | 2015-10-27 | 2016-03-30 | 山东省科学院海洋仪器仪表研究所 | Organic pollutant enrichment device in sea water |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106053198A (en) | 2016-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106053198B (en) | Agent liquid vortex oscillator and automatic analyzer | |
| CN103760375B (en) | Improved automatic biochemical analyzer and usage method thereof | |
| CN102998473B (en) | Full-automatic chemiluminescence immune analyzer | |
| CN106512831B (en) | Reagent evenly mixing device and method | |
| US20210132094A1 (en) | Reaction incubation device, immunity analyzer and reaction incubation method | |
| JPH0140649B2 (en) | ||
| CN103376333B (en) | Automatic clinical chemistry analyzer | |
| JP5400021B2 (en) | Automatic analyzer | |
| CN107254405A (en) | Fungal infection automatic tester | |
| CN203759028U (en) | Improved automatic biochemical analyzer | |
| CN206002555U (en) | A kind of Full-automatic chemiluminescence immunoassay analysis meter | |
| CN107044009B (en) | A kind of peg or spindle, rotating shuttle, sewing machine and shuttle thread allowance detector and method | |
| US3861197A (en) | Method and apparatus for determining the viscosity of a liquid sample | |
| CN105939766A (en) | Stirring/defoaming apparatus | |
| JP2010032386A (en) | Reaction table, analyzer, and stirring method | |
| JP2017015501A (en) | Agitation device, agitation system, blood platelet aggregation evaluation device, and agitating method | |
| CN208398892U (en) | The wave direction calibrating installation of wave buoy | |
| CN203606372U (en) | Automatic analysis device | |
| CN203502283U (en) | Detection sample stirring and uniform-shaking machine | |
| AU2019426631A1 (en) | Auxiliary device for detecting reconstitution property of milk powder | |
| CN204177727U (en) | POCT biochemical analyzer | |
| CN205333275U (en) | Time register for easy reference phase place failure diagnosis device | |
| CN205517430U (en) | Chlorinated rubber paint dispenser | |
| CN108981747A (en) | The wave direction calibrating installation of wave buoy | |
| CN207964617U (en) | The agitating device and automatic clinical chemistry analyzer of automatic clinical chemistry analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xiao Yujin Inventor after: Hu Kunhui Inventor after: Zhang Fuxing Inventor after: Long Feng Inventor after: Song Yongbo Inventor after: Hou Jinlong Inventor before: Hu Kunhui Inventor before: Xiao Yujin Inventor before: Zhang Fuxing Inventor before: Long Feng Inventor before: Song Yongbo |
|
| CB03 | Change of inventor or designer information | ||
| CB02 | Change of applicant information |
Address after: 518116 Yahui Long Biotechnology Plant, Baolong Street, Longgang District, Shenzhen City, Guangdong Province Applicant after: SHENZHEN YHLO BIOTECH CO., LTD. Address before: 518000 Guangdong, Shenzhen, Nanshan District Nanshan street, Xinghai Road, Li Shan Industrial Zone, 1-4 1-4 floors. Applicant before: SHENZHEN YHLO BIOTECH CO., LTD. |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |