CN106037965A - Individualized biomimetic dental implant and manufacture method thereof - Google Patents
Individualized biomimetic dental implant and manufacture method thereof Download PDFInfo
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- CN106037965A CN106037965A CN201610705563.XA CN201610705563A CN106037965A CN 106037965 A CN106037965 A CN 106037965A CN 201610705563 A CN201610705563 A CN 201610705563A CN 106037965 A CN106037965 A CN 106037965A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0036—Tooth replica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0093—Features of implants not otherwise provided for
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- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dentistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an individualized biomimetic dental implant and a manufacture method thereof. The invention is characterized in that the dental implant comprises an implant body for imitating the original tooth root tissue structure of a patient's missing tooth and also comprises a biomimetic artificial alveolar bone structure outer-layer for imitating a patient's alveolar bone tissue structure. The biomimetic artificial alveolar bone structure outer-layer and the external surface of the implant body are combined as a whole. The biomimetic tooth root implant body's outer layer is a 3D printed biomimetic artificial alveolar bone structure outer-layer which is combined with the implant body to form a whole structure, and is similar to the tissue structures of missing tooth's original tooth root and alveolar bone. Thus, the invention provides an ideal implementation scheme of a biomimetic artificial tooth root structure. What is the most important is that the invention provides a structure which is beneficial to bone marrow stem cell and osteogenesis-related cell adhesion, proliferation and mineralization and gives play to final osteogenic function and has good bioactivity. Therefore, a microenvironment for promoting osteogenesis is created, osteocyte generation is induced, and early rapid and firm synosteosis is realized.
Description
Technical field
The invention belongs to a kind of bio-medical tooth implant, particularly relate to the bionical tooth implant of a kind of individuation and
Manufacture method.
Background technology
Along with increase and social senilization's process of vehicle accident are accelerated, absence of tooth number increases year by year.Along with people
People's growth in the living standard, the reparation of defect of dentition and dentition defect is required day by day to improve by people.Along with planting technology is at full speed
Development, the increasingly extensive reparation being applied to defect of dentition and dentition defect of mouth cavity planting body, to recover attractive in appearance and function.In oral cavity
In field of planting, pure titanium metal (or alloy) is because of its good biocompatibility, mechanical property and corrosion resistance, and obtains wide
General application.But, there is the problem that traditional titanium implant mostly is full dense form, its elastic modelling quantity is the ten of natural sclerotin
Many times, mechanical compatibility is poor, produces stress collection with osseous tissue interface the most after the implantation and neutralizes stress shielding, reduces implantation body
Success rate and life-span at a specified future date.Metal or alloy itself that current implantation body is conventional are biologically inert, it is difficult to formed with osseous tissue
Quickly, good synostosis, prior art uses the processing modes such as sandblasting, acid etching and chemical treatment to carry out planting body surface mostly
Face is modified, although these methods increase surface roughness or strengthen surface activity, but there is the stability of surface-treated layer
Difference, biological activity is not enough, and healing stage is longer, for improving the problems such as mechanical compatibility effect is little.The most conventional plantation hands
Art mode is extension implant, owing to caused early stage is not mated more with the plantation nest organizational structure after exodontia and form in implantation body
Close the best problem so that have that operative cycle is short, risk is little, rapid recovery is attractive in appearance and function, avoid adjacent teeth and jaw tooth is moved
The immediate implant modus operandi of the clear superiorities such as position is difficult to use.Existing implantation body mostly is import, lacks independent intellectual property right
Implant system, owing to expense is too high, also constrains the popularization of its clinic, it is difficult to benefit vast agomphosis patient.Existing implantation body is big
Mostly being production line balance, shape, size and elastic modelling quantity are fixed range, it is impossible to carry out spirit according to the demand of individual
The adjustment lived, therefore, it is difficult to meet the demand of modern medicine Personalized medicine particularly precisely medical treatment.Additionally, existing implantation body
The course of processing random strong, surface imperfection, coating stability is poor, and reagent has corrosivity, to personnel health and environment guarantor
Protect and all produce harmful effect.The subject matter of existing implantation body is mainly summarized as the following aspects:
First existing implantation body is mainly full dense form implantation body, poor with the mechanical compatibility of natural bone tissue.Concrete table
Present: the fine and close elastic modelling quantity (110GPa) of titanium implants differs too big, at implant with the elastic modelling quantity (2-18GPa) of sclerotin
Being easily generated stress collection with osseous tissue interface and neutralize stress-shielding effect, bone interface easily occurs confirmed fatigue to destroy, causes implant
Loosen and dislocation, affect the success rate of implant.
Second existing implantation body material is biologically inert due to the metal used or alloy itself, in order to realize and bone
Organize the formation of quick, stable synosteosis, generally use physical modification and chemical modification method to carry out implant surface process, increase
Strong surface activity.But the coating stability that there is surface process is poor, and biological activity is not enough, and healing stage is longer, the course of processing
Not environmentally wait shortcomings.
1. what physical modification physical modification was conventional has sandblasting, acid etching, and sandblasting adds acid etching, and titanium slurry sprays, and laser treatment etc. is main
If the Ultrastructural change of implant surface.
(1) though sandblasting acid etching sandblasted and acid-etching can preferably increase implant surface roughness, but the coarse table formed
Face form is often irregular, surface stress skewness；Course of processing residual particulates is discharged in surrounding tissue after the implantation
Affect the synosteosis of implantation body；Preparation technology is unclean, not environmentally, have harm for processing staff's health.
(2) titanium slurry sprays whole implantation body is that a kind of material is prepared from, and can reduce the residual stress of interface, simultaneously
Increase surface area, the micro-coarse structured promotion synosteosis in early days of formation.Shortcoming is that operating procedure is complicated, bone regeneration around implant titanium granule
Existing, the stability of coating is under suspicion.
(3) laser method can produce preferable roughness, and in processing procedure, material is not required to contact implant surface, so
Implant surface will not be produced and pollute.It can only form the structures such as specific groove, texture in implant surface, it is impossible to
Realize the purpose of human simulation patient's nature bone morphosis of individuation.
2. the good biofacies that chemical modification is mainly had by this important bone biomimetic material of hydroxyapatite
Capacitive and bone guided effect and promote Integrated implant in early days.The preparation technology of hydroxyapatite coating layer mainly includes plasma spraying
Method, sol-gel process, ion beam assisted deposition, electrochemical deposition method, laser method, biomimetic method etc..
(1) plasma spraying method is strengthened implantation body and the mechanical bonding force of bone and disperses the stress of implantation body and bone interface.
It has a problem in that: substrate surface coating is uneven and cannot the face coat of manufacturing complex shapes base material；Treatment temperature in preparation
Too high (10000 DEG C), during cooling, between coating and substrate, the interfacial stress of residual makes coating loosen or peels off；High temperature easily makes HA divide
Solve dephasigns such as producing amorphous HA, affect the biological property etc. of coating.
(2) sol-gel process will be coated in implant surface by the colloidal solution of suitable calcium phosphorus ration preparation, then by adding
Heat, forms one layer of hydroxyapatite films being firmly combined with, significantly improves the synosteosis ability of implantation body.But sol-gal process
Haveing a problem in that gel has bigger contraction in sintering process, coating is easy to crack.
(3) laser method coats a certain proportion of CaHPO on substrate material surface in advance4·2H2O and CaCO3Mixed powder
End, then carries out cladding process with laser instrument, makes synthesis complete with coating hydroxyapatite coating layer one step.The coating prepared and base
Being well combined of the end, hardness, intensity are higher, have certain toughness, but the uniformity of coating and the more difficult control of stability.
(4) the mineralising mechanism of biomimetic method natural imitation circle physiology apatite, its feature be bionic coating natural sediment and
Becoming, composition, closer to the inanimate matter of human bone, has higher biocompatibility and synosteosis ability.But have the disadvantage that, place
The reason time is long, complex process, it is difficult to the problems such as volume production.
3rd the most conventional implant operation mode is extension implant, and the bionical implantation body of individuation contributes to realizing from prolonging
Phase plantation becomes immediate implant.At present conventional implant operation mode is extension implant, conventional for screw-like and post
The single root of the tooth rotary type implantation body of shape structure, owing to the tooth socket shape after finished product implantation body and exodontia and organizational structure differ
Causing, cause implantation at once can be commonly present gap between implantation body and osseous tissue, biocompatibility is not good enough, affects quickly-healing, nothing
Method realizes immediate implant.Therefore, the plantation after prior art is made up implantation body by prolongation implantation body healing time and had tooth pulled out
Nest form and the best problem of inconsistent the brought immediate union of organizational structure, thus obtain good primary stability.Also
That is, the implantation of implantation body typically requires after exodontia by the time 3 to 6 months or longer opportunity.Extension implant is relative at once planting
The shortcoming of implant mainly has:
1) implant operation can just be carried out after teeth socked healing in conventional 3 to 6 months, it is impossible to after exodontia, at once recover patient beautiful
See and function.
2) exodontia and implant operation are carried out by stages, and after adding exodontia, osseous tissue healing causes the bone amount in exodontia site to run off
With the preparation plantation nest process operation wound to osseous tissue.Extend the treatment cycle of patient, add the misery of patient and control
Treatment expense.
3) lack teeth socked the correct of implant trajectory is effectively guided, add operation complexity and due to
Implant trajectory deviation causes the operation risk destroying the important feature such as nerve, blood vessel.It is difficult to obtain and preferably dissects position
Put, affect the attractive in appearance and biomechanical compatibility that later stage corona is repaired.
4) cannot effectively preserve gingival papilla, affect the aesthetic effect after implant prostheses.
5), after exodontia, failing Immediate prosthesis causes lacking in teeth socked agglutination and repairs in time cause stretch jaw tooth
Long shift and the angular displacements of adjacent teeth, affect later stage repairing effect.
4th existing implantation body is mostly import, and plantation is repaired sizable a part of expense and all originated from high import kind
Implant material cost, causes planting rehabilitation expense and remains high, significantly increase the financial burden of patient, and constrain plantation
The clinical further genralrlization of artificial tooth technology, it is difficult to benefit vast agomphosis patient.
At present the implant system of main flow both is from greatly developed country the most in the world, including Switzerland (Shi Zhuoman, straumann),
Germany (Semados), Sweden (Nobel Biocare), the U.S. (Biomet 3i；And Korea S (Osstem, difficult to understand tooth safe) Bicon).
Compared with the above-mentioned big implant system in the world six, although domestic implant system also has the CDIC implant system of West China, Sichuan university
Supporting Deng earnestly, but compare with external system, domestic implant system is a weakness all the time, owing to lacking strict implant matter
The system design that amount controls, diversified reparation selects, perfect case is followed the tracks of and grows with each passing hour, with wanting of clinical application
Seek sizable gap.Although the implantation body consumed in China every year is more than 400,000, but almost more than 95% facing
The implantation body that bed uses is imported product, and the use of domestic implant system is few.And advancing domestic implantation body to develop
Cheng Zhong, the mode of production of regular pipeline volume production lacks strict implant quality control, lacks diversified reparation and be selected to
Restrict the bottleneck of domestic implantation body development；The domestic implantation body obtaining independent intellectual property right is made to be difficult to dominate the market.
5th existing implantation body production line balance mode cannot adapt to modern medicine Personalized medicine and the need of precisely medical treatment
Ask, be unfavorable for the foundation of harmony hospital
The oral condition of patient varies, and needs refinement, can farthest meet the demand of patient.Existing
Having implantation body is streamline volume production mostly, and shape, size and elastic modelling quantity are fixed range, and choice is the least, it is difficult to pin
The individual variation of each patient is adjusted correspondingly.Especially for there being general disease, (such as diabetes and sclerotin are dredged
Pine) patient, if or conventional popular machine-made implantation body, be just difficult to cut the garment according to the figure according to individual
Demand adjust flexibly, it is impossible to reach the satisfaction of best repair effect and patient, buried for doctor-patient dispute potential
Risk, is unfavorable for the foundation of the doctor-patient relationship of harmony.Thus, the processing technology of existing implantation body constrains plantation greatly and repairs
Popularization, it is impossible to adapt to modern medicine Personalized medicine, the particularly precisely demand of medical treatment.
The processing method of the 6th existing implantation body
Sandblasting acid etching and chemical processes that existing surface modification is used also exist course of processing randomness by force, nothing
Method realizes uniform surface, rule, repeatably surface treatment effect, and face coat poor stability, easily occurs dissolving, taking off
The problem fallen.Have the reagent such as soda acid to add due to the course of processing, later stage cleaning is not thorough, easily produces the different journeys of noxious substance
The residual of degree, the healing effect that impact implants, even result in and plant unsuccessfully.And, the many examinations used in processing technique
Agent has severe corrosive, has damage in various degree to personnel health, and discarded reagent can produce bad shadow to environmental conservation again
Ring.
The defect of prior art: existing full dense form implantation body also exists elastic modelling quantity and do not mates with osseous tissue and cause
The best and that synosteosis the is slow in early days problem of mechanical compatibility.Although being intended to be processed from physical arrangement (surface by implant surface
Pattern is coarse) and the structure of two aspects simulation natural bone tissue of chemical composition (increase calcium phosphorus content), thus improve plantation
The biocompatibility of surface, but eventually there is bigger difference with the structure of natural bone tissue, thus three-dimensional cannot be obtained
The bionic tone tissue structure of porous network shape；Particularly cannot realize the alveolar bone tissue structure with individual and shape is special
Point matches applicable, and the major defect that prior art all exists uses streamline volume production exactly, and shape, size range are solid
Fixed, lack the structure bionical with the natural bone tissue to greatest extent body construction as implantation body, final acquisition is preferably
The quickest and firm synosteosis.This critical defect, on the one hand hinder greatly have that operative cycle is short, risk is little,
Recover rapidly attractive in appearance and function, avoid what adjacent teeth and the immediate implant to multiple advantages such as jaw tooth displacements performed the operation to carry out；The opposing party
Face limits research and development and the popularization of domestic implantation body, it is difficult to meet the need of modern medicine Personalized medicine particularly precisely medical treatment
Ask.But also it is random strong to there is the course of processing, the result heterogeneity that surface processes, poor stability, it is difficult to the problem of control
And after coating preparation can not stable for extended periods of time, easily occur dissolving, come off, the problem of course of processing pollution.Additionally, due to
Processing reagent has severe corrosive, and personnel health and environmental conservation are had harmful effect.
Summary of the invention
The present invention solves technical problem present in known technology and provide one can to greatest extent with nature bone group
Knit bionical tooth implant of individuation that bionical structure constitutes and preparation method thereof.
The present invention solves that technical problem present in known technology is taked for the tooth implant that individuation is bionical
Technical scheme is: it includes implantation body's body, and described implantation body's body is the imitative original root of the tooth of patient's missing tooth or offside
Homonym teeth root of the tooth and under offside Homonym teeth deletion condition, chosen position closest to or the closest root of the tooth organizational structure of function
Implantation body's body of biomimetic prosthetic root of the tooth organizational structure；Also include and be combined as a whole with described implantation body body outer surface
The outer layer of the biomimetic prosthetic alveolar bone tissue structure of imitative patient's alveolar bone tissue structure.
The present invention can also adopt the following technical scheme that for the tooth implant that individuation is bionical
Described implantation body's body is also based on the recovery original root of the tooth of patient's missing tooth or the offside of medical image
Homonym teeth root of the tooth or under offside Homonym teeth deletion condition, chosen position closest to or the plantation of the closest root shape of function
Body body.
The thickness of the outer layer of the biomimetic prosthetic alveolar bone structure of described imitative patient's alveolar bone tissue structure is 0.2-3.0 milli
Rice.
The present invention solves the making side for the bionical tooth implant of individuation of technical problem present in known technology
Method is adopted the technical scheme that: described tooth implant body and biomimetic prosthetic alveolar bone structural outside layers are an overall structure,
It includes following steps:
Obtain the remaining root of the tooth of patient and the medical image of alveolar bone tissue structure；From the medical image number of above-mentioned acquisition
Alveolus around implantation body's body construction of required imitative missing tooth original root of the tooth organizational structure and imitative missing tooth is extracted according to
The data of the layer structure of bone structure；Set up described implantation body body and the bionical manual tooth planting of layer structure individuation
The three-dimensional digital model of body；The implanting body of artificial tooth three-dimensional digital model bionical to individuation carries out format conversion；By described lattice
Formula convert after have individuation bionical implanting body of artificial tooth mathematical model software input 3D printing device carry out individuation imitate
The 3D solid manufacture of raw implanting body of artificial tooth.
The present invention solves the making side for the bionical tooth implant of individuation of technical problem present in known technology
Another technical scheme that method is taked is: described tooth implant body and biomimetic prosthetic alveolar bone structural outside layers are an entirety
Structure, it includes following steps:
Obtain the remaining root of the tooth of patient and alveolar bone tissue structure and the medical image of remaining root shape；From above-mentioned
The medical image obtained extracts required recovery patient's original dental root shaped of missing tooth based on medical image
Implantation body's ontology data of shape and organizational structure and the imitative missing tooth surrounding socket bone group being attached to described implantation body body surface
Knit the layer structure data of structure；Set up described implantation body body and the three of the bionical implanting body of artificial tooth of layer structure individuation
Dimension word model；The implanting body of artificial tooth three-dimensional digital model bionical to individuation carries out format conversion；By described format conversion
After have individuation bionical implanting body of artificial tooth mathematical model software input 3D printing device carry out the people that individuation is bionical
The 3D solid manufacture of work tooth implant.
The present invention has the advantage that with good effect: owing to using 3D printing technique to carry out implantation body's processing, mainly have
Advantages below:
1. individuation biomimetic features has splendid mechanical compatibility
Full dense form titanium implant has big difference with the elastic modelling quantity of osseous tissue, causes not mating, thus suppresses implantation body
The formation of surrounding bone, or the sponginess change of surrounding bone, even cause the atrophic of bone regeneration around implant bone or traumatic absorption,
Cause implantation body to loosen eventually or fracture, cause and plant unsuccessfully.Due to the fact that the structure using overall individuation bionical, maximum limit
The structure simulating natural sclerotin of degree, relative to traditional centre fine and close entity entirely, the implantation body that only top layer is modified substantially reduces
Elastic modelling quantity, is allowed to close with the elastic modelling quantity of surrounding sclerotin, reaches good coupling.Reduce gross weight simultaneously, and strong
Degree reaches clinical demand.The implantation body of low elastic modulus is conducive to the form of compressive stress, the load of implantation body is delivered to bone group
In knitting, the shear stress at implantation body-synosteosis interface can be reduced, be effectively improved the biomechanical compatibility of implantation body.This changes
Enter fundamentally to solve conventional implantation body not mate caused stress collection with osseous tissue elastic modelling quantity and neutralize stress shielding and lead
The problem of the mechanical compatibility difference caused, improves the success rate of implantation body and life-span at a specified future date.
2. individuation is bionical structure promotes quickly, synosteosis in early days
The present invention is relative to the primary advantage of the surface modification obtained by traditional physics or chemical surface treatment mode
Being, the surface that traditional approach obtains is only capable of obtaining relatively simple single groove, shallow hole or tubular structure, or several
Plant the cumulative of simple structure, but, the present invention is capable of 3 D stereo network structure, farthest simulates the knot of nature bone
Structure form, generally acknowledge at present, porous three-dimensional stereochemical structure compared with traditional simple single groove, shallow hole or tubular structure,
Surface area significantly increases, and loose structure is advantageously climbed in osteoblast, adheres to, and embeds, and then firmly connects and promote
The mode entering new bone formation is the more preferably direct skeletonization of implant surface.
Relative to another big advantage of traditional physics or chemical surface treatment modification, the present invention is that individuation is bionical
Structure not only realize the most bionical in physical arrangement and micromorphology, and be follow-up on this basis add nature bone
Chemical composition (such as calcium phosphorus, hydroxyapatite etc.) even has medicative medicine, and (such as treat diabetes, sclerotin is dredged
Pine and anti-inflammatory drug etc.) establish firm architecture basics.Additionally, porous three-dimensional three-dimensional surface is simple single recessed with traditional
Groove, shallow hole or tubular structure are compared, and are also more prone to realize medicament slow release, thus be expected to solution there are diabetes, sclerotin is dredged
The patient of the general diseases such as pine plants failed problem, expands the indication of implant prostheses, brings glad tidings for patient.
Generally acknowledging the most at present, immediate implant, compared with extension implant, mainly has the advantage that
1) before exodontia, the bionical plantation of individuation can be made in advance according to missing tooth original root of the tooth organizational structure and shape
Body, at once implants teeth socked, i.e. exodontia and implant operation by the bionical implantation body of individuation made in advance after exodontia and carries out the same period,
Shortening the patient treatment cycle, very first time recovery is chewed with attractive in appearance, improves the quality of life of patient.By conventional 3 to 6 months
After implant operation merge with tooth extraction procedure, alleviate patient suffering, reduce medical expense, reduce patient and run off.
2) exodontia and implant operation are carried out the same period, reduce conventional extension implant technology bone amount after osseous tissue heals and run off
With the preparation plantation nest process operation wound to osseous tissue.
3) teeth socked can effectively guide implantation body to implant along correct direction, greatly reduces operation complexity, letter
Change surgical procedure, reduce owing to the deviation of directivity causes destroying the operation risk of the important feature such as nerve, blood vessel.It is easier to obtain reason
The anatomical position thought, facilitates later stage corona reparation, more meets requirement attractive in appearance and biomechanics.
4) effective preservation of gingival papilla, improves the aesthetic effect after implant prostheses.
5) after effectively prevention is had tooth pulled out, teeth socked agglutination extends to jaw tooth displacement and the angular displacements of adjacent teeth, protect
Card later stage repairing effect.
The present invention passes through individuation bionics techniques, the tooth socket organizational structure after can effectively realizing implantation body and having tooth pulled out
With the accurate coupling of shape, the most overall bionical structure contribute to implantation body and surrounding sclerotin quickly, synosteosis in early days, perfect
Solve existing implantation body and be dfficult to apply to the problem of immediate implant, there is extremely prominent advantage.
Owing to immediate implant is compared with extension implant, there is many significant advantages, and the present invention successfully solves at once
The problem of plantation, thus realize immediate implant, therefore there is particularly important meaning, huge society and warp after enforcement, can be created
Ji benefit.
4. overcome the dependence for import implantation body, it is achieved the great-leap-forward development of domestic implantation body
For promoting the sound development in national brand tooth-planting market at home, the present invention passes through the bionical implantation body of individuation
Technology from source, eliminate that existing domestic implantation body production line balance brought be difficult to ensure that strict quality monitoring is led
Cause the unstable problem of implantation body's quality and lack of the problem that the variation of each patient selects, directly passing through computer
Aided Design, 3D print processing, customized for patient and make the implantation body of individuation the same period.Individuality provided by the present invention
Change the technology of bionical implantation body relative to tradition import implantation body, not only there is the most bionical advantage, and for system
Make that technological requirement is relatively low, doctor is easy to grasp, no longer make excessive demands strict implant quality control, and directly provide than original import
Implantation body is diversified repairs the customization selecting the most superior individuation.Innovation in this technical thought is expected to realize crossing over
Formula develops so that the design of domestic implantation body and making meet head on to catch up with and surpass developed country；Thus provide technology for production domesticization implantation body
Ensureing, technical foundation is established by the domestic implantation body for research and development with independent intellectual property right.
5. Individual design makes and simplifies link and step, precisely medical treatment, promotes the foundation of harmony hospital
Doctor directly can be applied to the manufacturing process of final implantation body by the present invention for the design concept of implantation body, and
And individuation, digitized Design and Machining process greatly facilitate doctors and patients' exchange, remove the processing link of producer's pipeline system,
Make implantation body the most more press close to individual's demand, and reduce the link, shorten the time, reduce expense, reduce simultaneously
The possibility that the uncertainty of the final implantation body too much caused due to link and error occur.
Owing to using the desired implantation body of Individual design in advance compactness extent, it is possible to achieve by the consistency of its implantation body
Reach farthest to approach with the eburnation degree of individual patients, it is to avoid overly hard at sufferers of osteoporosis face et al. Ke
The excessive implantation body of elastic modelling quantity cause not mating and tardy synosteosis between body osseous tissue, even plant failure.
For diabetes and sufferers of osteoporosis face, it is also possible to had by the biomimetic prosthetic alveolar bone area load in the present invention
There are treatment diabetes and osteoporosis effect and the medicine of anti-inflammatory thus promote individual patients the most stage by stage
Osseointegrated implants.Such as diabetics, load Remedies for diabetes on implantation body's biomimetic prosthetic alveolar bone surface,
The plantation failure that prevention diabetes cause, improves plantation success rate.
The sharpest edges of individuation technology and precisely medical treatment are exactly can to meet the individual demand of patient to greatest extent, make
Obtain patient in medical by implanting the unique implantation body the most perfect tooth lacked of repairing, and
And it is joyful to experience great considered psychology by the service of private customized formula psychologically, the technology of the present invention led
The transformation of this reparation theory, help lend some impetus to the foundation of harmony hospital, of increasing concern at current conflict between doctors and patients
Period there is particularly important and profound significance.
6. course of processing precision, cleaning, environmental protection
Processing is carried out according to software and the program of pre-designed STL form completely, it is possible to avoid tradition completely
The course of processing brought of surface treatment mode random strong, result heterogeneity that surface processes, poor stability, it is difficult to control with
And the course of processing is unclean, the problem such as not environmentally.
The course of processing is by cleaning the direct radiation modality of light source laser successively high-temperature fusion titanium or titanium alloy metal dust, right
Carry out multi-shell curing in tooth implant body and outer layer biomimetic prosthetic alveolar bone structure entirety thereof, therefore can avoid tooth implant
Sealing-off between body and outer layer biomimetic prosthetic alveolar bone structure sheaf thereof affect the problem of intensity and the defect that causes of casting and
The problem that the course of processing is polluted.Processing overall process is carried out in confined space, it is achieved that cleaning, environmental protection, it is entirely avoided aforementioned
Sandblasting, acid etching process is for the Health cost of processing staff and environmental pollution.
Accompanying drawing explanation
Fig. 1 is one of tooth implant structural representation of the present invention；
Fig. 2 is the two of the tooth implant structural representation of the present invention；
Fig. 3 is the three of the tooth implant structural representation of the present invention；
Fig. 4 is the four of the tooth implant structural representation of the present invention；
Fig. 5 is the five of the tooth implant structural representation of the present invention；
Fig. 6 is the six of the tooth implant structural representation of the present invention；
Fig. 7 is the seven of the tooth implant structural representation of the present invention.
Detailed description of the invention
For present disclosure, feature and effect can be further appreciated that, hereby enumerate following example, and coordinate accompanying drawing detailed
It is described as follows:
As shown in figs. 1-7, a complete implant denture is mainly made up of three parts: corona 4, base station 3, implantation body's body
1.Wherein, implantation body's body 1 be print with 3D constitute the imitative original root of the tooth of patient's missing tooth or offside Homonym teeth root of the tooth and
Under offside Homonym teeth deletion condition, the biomimetic prosthetic root of the tooth knot of tissue of the root structures that chosen position is closest or function is closest
Structure.Implantation body's body 1 is the part that implant denture is combined with osseous tissue, i.e. artificial tooth root, is implanted directly into the alveolar bone of patient, rises
To fixing supporting role.Base station 3, between implantation body's body 1 and corona 4, connects implantation body's body 1 to root side, to hat Fang Lian
Connect corona 4, play the effect formed a connecting link.Base station 3 can be fabricated separately or can also be for being printed with implantation body originally by 3D
Body 1 integral manufacturing.Implantation body's body 1 and base station 3 are all not directly exposed to oral cavity, only corona 4 and are partially exposed in oral cavity, are
Play the part of final attractive in appearance and masticatory function.The outer layer of tooth implant body 1 is to print and implantation body's body composition with 3D
The outer layer 2 of the Bionics Bone structure of one integrally-built imitative patient's missing tooth surrounding socket bone organizational structure.
As the present invention can be used for following a few class:
One, about the shape of implantation body's body 1:
1., such as Fig. 1, shown in 2,4, implantation body's body 1 is cylindric or conical outer form.
2., such as Fig. 3, shown in 5,7, implantation body's body 1 is the original root of the tooth of patient's missing tooth made based on medical image data
Implantation body's body of shape (in the case of there is no the original root data of missing tooth, choose offside Homonym teeth root shape or
Under offside Homonym teeth deletion condition, the root shape data that chosen position is closest or function is closest substitute).This shape can
Directly to restore, to copy the original root shape of missing tooth or approximate original root shape or carry out according to biocompatibility principle
Adjust (such as biomechanical compatibility etc.).Wherein Fig. 3,5 is double root shape, and Fig. 7 is single root shape.
The most as shown in Figure 6, implantation body's body 1 is threaded the shape of structure for surface.
Two, about implantation body's body 1 and the connected mode of base station 3:
4., such as Fig. 1, shown in 2,4,5,6,7, implantation body's body 1 and base station 3 connect for one-part form, i.e. implantation body's body 1 He
Base station 3 be overall manufacture, integrated.
5., as it is shown on figure 3, implantation body's body 1 and base station 3 are by Screw retained, also minority is that taper lock connects (not
List).
Three, base station 3 and the connected mode of corona 4:
6., such as Fig. 1, shown in 2,4,6,7, the connection of base station 3 and corona 4 is for passing through Screw retained.
7., such as Fig. 3, shown in 5, the connection of base station 3 and corona 4 is cemented retention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.
The manufacture method one of the present invention is: it includes following steps:
Step one, obtain the remaining root of the tooth of patient and the medical image of alveolar bone tissue structure with CT or CBCT；
Step 2, the medical image obtained from step one extract required imitative missing tooth original root of the tooth group
Knit implantation body's body organizational structure of structure and be attached to the imitative missing tooth surrounding socket bone organizational structure of implantation body's body surface
Outer layer bionical alveolar bone tissue structured data；
Step 3, the data extracted in step 2 are processed, build implantation body's body organization structural model and outer
The bionical alveolar bone tissue structural model of layer, adds the implantation body's shape data in data base, in conjunction with shape data and structured data,
The comprehensive three-dimensional digital model building the bionical implanting body of artificial tooth of individuation；
The implanting body of artificial tooth 3-dimensional digital that step 4, the individuation utilizing 3 d modeling software step 3 to be set up are bionical
Model carries out format conversion, and implanting body of artificial tooth three-dimensional digital model bionical for individuation is changed into 3D printing device can identify
The formatted file such as STL；
Step 5, the stl file of implanting body of artificial tooth bionical for individuation is inputted 3D printing device carry out artificial tooth's kind
The 3D solid manufacture of implant.
The manufacture method two of the present invention: it includes following steps:
Step one, obtain the remaining root of the tooth of patient and alveolar bone tissue structure and the doctor of remaining root shape with CT or CBCT
Learn view data；
Step 2, the medical image obtained from step one extract required based on medical image
Restore the original root shape of patient's missing tooth and implantation body's ontology data of organizational structure and be attached to implantation body's body surface
The outer layer bionical alveolar bone tissue structured data of imitative missing tooth surrounding socket bone organizational structure；
Step 3, the data extracted in step 2 are processed, build implantation body's body organization structural model and outer
The bionical alveolar bone tissue structural model of layer, adds the implantation body's shape data extracted in step 2, and the comprehensive individuation that builds is imitated
The three-dimensional digital model of raw implanting body of artificial tooth；
The implanting body of artificial tooth 3-dimensional digital that step 4, the individuation utilizing 3 d modeling software step 3 to be set up are bionical
Model carries out format conversion, and implanting body of artificial tooth three-dimensional digital model bionical for individuation is changed into 3D printing device can identify
The formatted file such as STL；
Step 5, the stl file of implanting body of artificial tooth bionical for individuation is inputted 3D printing device carry out artificial tooth's kind
The 3D solid manufacture of implant.
The subject matter of existing implantation body is: full dense form implantation body mechanical compatibility is poor, biological activity not enough, healing
Phase is long；Extension implant causes treatment cycle length, cannot recover rapidly attractive in appearance and function, adjacent teeth and to jaw tooth displacement；Implantation body takes
With too high, shape, size are single, dumb；Face coat poor stability, personnel health and environmental conservation are produced by processing reagent
Harmful effect.The present invention is directed to the deficiency that existing implantation body exists, by the kind of imitative patient's missing tooth original root of the tooth organizational structure
The biomimetic prosthetic alveolar bone knot of imitative patient's alveolar bone tissue structure that implant body and implantation body's body outer surface are combined as a whole
Structure, produces the bionical individuation artificial growth body the most close with individual patients root of the tooth and alveolar bone tissue structure.This
Invention is successfully realized fine, environmental protection that tooth implant makes, controlled, homogeneous, bionical；By customized type individuation biomimetic prosthetic
The manufacture of implantation body, meets tooth implant individuation and the demand become more meticulous in clinical oral plantation；Greatly reduce due to
The interface that traditional tooth implant is excessive with individual patients jawbone elastic modelling quantity gap and causes produces stress collection and neutralizes stress screening
Gear, improves implant surface biological activity, and creates the favourable configurations condition of porosity and looseness for follow-up medicine carrying.The present invention makes
Obtain immediate implant to be possibly realized, shorten healing cycle, reduction plantation expense recovering rapidly attractive in appearance while function, also realize
The course of processing of clean environment firendly.After implanting body of artificial tooth bionical for individuation of the present invention is implanted human body, can be
The root of the tooth of the simulated patient individuation of limits and alveolar bone tissue architectural characteristic, preferably mate with patient's natural bone tissue,
Shorten crop cycle, reach the synosteosis that fast and stable is long-term, it is achieved the precisely requirement of medical treatment.
Claims (5)
1. the tooth implant that individuation is bionical, it includes implantation body's body, it is characterized in that: described implantation body's body is
Imitate the original root of the tooth of patient's missing tooth or offside Homonym teeth root of the tooth or under offside Homonym teeth deletion condition, chosen position is closest
Or implantation body's body of the biomimetic prosthetic root of the tooth organizational structure of the closest root of the tooth organizational structure of function；Also include and described kind
The outer layer of the biomimetic prosthetic alveolar bone tissue structure of imitative patient's alveolar bone tissue structure that implant body outer surface is combined as a whole.
The tooth implant that individuation the most according to claim 1 is bionical, it is characterised in that: described implantation body's body is still
Recovery patient's original root of the tooth of missing tooth based on medical image or offside Homonym teeth root of the tooth or lack at offside Homonym teeth
In the case of, implantation body's body of the root shape that chosen position is closest or function is closest.
The tooth implant that individuation the most according to claim 1 and 2 is bionical, it is characterised in that: described imitative patient's alveolus
The thickness of the outer layer of the biomimetic prosthetic alveolar bone structure of bone structure is 0.2-3.0 millimeter.
4. the manufacture method of the tooth implant that an individuation according to claim 1 is bionical, it is characterised in that: described
Tooth implant body and biomimetic prosthetic alveolar bone structural outside layers are an overall structure, and it includes following steps:
Obtain the remaining root of the tooth of patient and the medical image of alveolar bone tissue structure；From the medical image of above-mentioned acquisition
Extract implantation body's body construction of required imitative missing tooth original root of the tooth organizational structure and imitative missing tooth surrounding socket bone group
Knit the data of the layer structure of structure；Set up described implantation body body and the bionical implanting body of artificial tooth of layer structure individuation
Three-dimensional digital model；The implanting body of artificial tooth three-dimensional digital model bionical to individuation carries out format conversion；Described form is turned
To carry out individuation bionical for the bionical implanting body of artificial tooth mathematical model software input 3D printing device of individuation that has after change
The 3D solid manufacture of implanting body of artificial tooth.
5. the manufacture method of the tooth implant that an individuation according to claim 1 is bionical, it is characterised in that: described
Tooth implant body and biomimetic prosthetic alveolar bone structural outside layers are an overall structure, and it includes following steps:
Obtain the remaining root of the tooth of patient and alveolar bone tissue structure and the medical image of remaining root shape；From above-mentioned acquisition
Medical image in extract required recovery patient's original root shape of missing tooth based on medical image and
Implantation body's ontology data of organizational structure and the imitative missing tooth surrounding socket bone knot of tissue being attached to described implantation body body surface
The layer structure data of structure；Set up described implantation body body and three dimensions of the bionical implanting body of artificial tooth of layer structure individuation
Word model；The implanting body of artificial tooth three-dimensional digital model bionical to individuation carries out format conversion；After described format conversion
The implanting body of artificial tooth mathematical model software input 3D printing device having individuation bionical carries out the artificial tooth that individuation is bionical
The 3D solid manufacture of implantation body.
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| CN201610705563.XA CN106037965A (en) | 2016-08-23 | 2016-08-23 | Individualized biomimetic dental implant and manufacture method thereof |
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| ES2677607A1 (en) * | 2017-02-03 | 2018-08-03 | Felipe MARTÍNEZ MARTÍN | Dental implantology design with direct loading and obtaining procedure (Machine-translation by Google Translate, not legally binding) |
| CN109332698A (en) * | 2018-12-04 | 2019-02-15 | 湖南顶立科技有限公司 | A kind of the 3D printing method and mouth cavity planting body of mouth cavity planting body |
| CN110043062A (en) * | 2019-05-14 | 2019-07-23 | 贵州省山地资源研究所 | A kind of sampling stalagmite restorative procedure |
| CN110478072A (en) * | 2019-07-31 | 2019-11-22 | 北京大学口腔医学院 | A kind of 3D printing production method of accurate bionic ceramic dental case |
| CN111227965A (en) * | 2020-01-17 | 2020-06-05 | 北京大学口腔医学院 | Design and manufacturing method of surface structure of artificial periodontal ligament dental implant |
| CN112451136A (en) * | 2020-11-13 | 2021-03-09 | 北京联袂义齿技术有限公司 | Preparation method of 3D printed dental implant |
| CN115089328A (en) * | 2022-06-17 | 2022-09-23 | 汪晓晖 | Dental implant system with surface gradient microporous structure and preparation method thereof |
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| CN111227965B (en) * | 2020-01-17 | 2022-03-01 | 北京大学口腔医学院 | Design and manufacturing method of surface structure of artificial periodontal ligament dental implant |
| CN111227965A (en) * | 2020-01-17 | 2020-06-05 | 北京大学口腔医学院 | Design and manufacturing method of surface structure of artificial periodontal ligament dental implant |
| CN112451136A (en) * | 2020-11-13 | 2021-03-09 | 北京联袂义齿技术有限公司 | Preparation method of 3D printed dental implant |
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| US11484396B1 (en) * | 2021-06-21 | 2022-11-01 | Identical, Inc. | Root-analog dental implants and systems, devices, and methods for designing and manufacturing same |
| US20230036820A1 (en) * | 2021-06-21 | 2023-02-02 | Identical, Inc. | Root-analog dental implants and systems, devices, and methods for designing and manufacturing same |
| US11833001B2 (en) * | 2021-06-21 | 2023-12-05 | Identical, Inc. | Root-analog dental implants and systems, devices, and methods for designing and manufacturing same |
| CN115089328A (en) * | 2022-06-17 | 2022-09-23 | 汪晓晖 | Dental implant system with surface gradient microporous structure and preparation method thereof |
| US11819381B2 (en) | 2022-06-17 | 2023-11-21 | Xiaohui Wang | Dental implant system with surface gradient microporous structure and a preparation method thereof |
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Application publication date: 20161026 |