CN106037699A - Circuit for extracting non-invasive blood pressure Korotkoff's sound and sphygmomanometer - Google Patents

Circuit for extracting non-invasive blood pressure Korotkoff's sound and sphygmomanometer Download PDF

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Publication number
CN106037699A
CN106037699A CN201610546945.2A CN201610546945A CN106037699A CN 106037699 A CN106037699 A CN 106037699A CN 201610546945 A CN201610546945 A CN 201610546945A CN 106037699 A CN106037699 A CN 106037699A
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korotkoff
sound
pass filter
blood pressure
connects
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Inventor
黄真江
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Suzhou Coffee Health Mdt Infotech Ltd
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Suzhou Coffee Health Mdt Infotech Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/0225Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02141Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7221Determining signal validity, reliability or quality
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Power Engineering (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

The invention discloses a circuit for extracting non-invasive blood pressure Korotkoff's sound. The circuit comprises a sound pickup, a first high-pass filter, an amplifier, a first low-pass filter, a digital filter, a second low-pass filter, a power amplifier and a loudspeaker, wherein the sound pickup is used for extracting original Korotkoff's sound audio signals; the first high-pass filter is connected to the sound pickup and is used for filtering and removing clutters that frequency is lower than that of Korotkoff's sound; the amplifier is connected to the first high-pass filter and is used for amplifying the Korotkoff's sound audio signals; the first low-pass filter is connected to the amplifier and is used for preventing aliasing of the Korotkoff's sound audio signals; the digital filter is connected to the first low-pass filter and is used for filtering and removing clutters interfered by commercial power frequency, so that extracted Korotkoff's sound audio signals are formed; the second low-pass filter is connected to the digital filter and is used for smoothing the extracted Korotkoff's sound audio signals; the power amplifier is connected to the second low-pass filter and is used for amplifying the Korotkoff's sound audio signals; and the loudspeaker is connected to the power amplifier and is used for turning up the Korotkoff's sound audio signals, so that the Korotkoff's sound is stably extracted with high precision.

Description

A kind of circuit extracting non-invasive blood pressure Korotkoff's Sound and sphygomanometer
Technical field
The present invention relates to extraction circuit and the sphygomanometer of a kind of Korotkoff's Sound, extract non-invasive blood pressure Korotkoff's Sound particularly to one Circuit and sphygomanometer.
Background technology
Measure the important way that blood pressure is prevention apoplexy.The method of noinvasive measuring blood pressure has auscultation (Korotkoff's Sound method) and oscillography Method (Sasser method), both approaches is respectively arranged with quality, and Korotkoff's Sound method is measured relatively accurate, but individual poor repeatability, Sasser method can Reproducible, but measure and have error.At present, on market, most upper Arm-cuff device is all to use Sasser method by filling Several parts compositions such as gas cuff, pressure transducer, inflator pump, air bleeding valve, power supply, control circuit.
So-called Korotkoff's Sound method, is a kind of method utilizing Korotkoff's Sound no-invasive measurement of blood pressure.Under normal circumstances, static pressure is first increased (not detecting Korotkoff's Sound), the most progressively blood pressure lowering until tremulous pulse is obstructed completely, the static pressure corresponding to first time Korotkoff's Sound measured is Shrinking pressure, along with further blood pressure lowering, arteries is complete blocking, gradually open, the change procedure of standard-sized sheet, the respective change of Korotkoff's Sound Being divided into five phases until disappearing, the static pressure corresponding to last Korotkoff's Sound measured before disappearance is diastolic pressure.
During using Korotkoff's Sound method sphygomanometer, use tradition mercurial sphygmomanometer by subjective factors and the skilled journey of doctor Spending different, two doctors may have the difference of more than 10mm mercury column to same patient auscultated results at short notice.
And electric sphygmomanometer, use Korotkoff's Sound method to listen pulse tone electronic pick-up to complete, apparatus judging method and people Work is almost identical.Easily by external interference, i.e. extraneous other acoustical vibrations etc. all can affect accuracy of measurement, the pulse of different people Power also has certain impact to measurement result.And, the auscultation electric sphygmomanometer algorithm principle of each family is different, does not the most unite The comparative approach of one, accuracy of measurement is the most each different.
Meanwhile, audio amplifier circuit relates to the amplification of analogue signal, filtering principle, it may be desirable to more complicated circuit design and More electronic devices and components, such as operational amplifier, typically can use 3 to 4 operational amplifiers, and many reaches 7,8 computings Amplifier.Operational amplifier is sophisticated integrated circuits, its price higher than ordinary electronic components and parts, especially scale volume production time Waiting, this is a no small cost.And the wave filter capacity of resisting disturbance that is made up of multilevel amplifiers is more weak, affects final survey Dose-effect fruit.
In order to solve tradition mercurial sphygmomanometer or the error of electric sphygmomanometer existence, solve available circuit cost simultaneously A higher difficult problem, need to design a kind of be not easily susceptible to external interference and cost reasonably extract non-invasive blood pressure Korotkoff's Sound circuit and Sphygomanometer.
Summary of the invention
It is an object of the invention to provide a kind of circuit extracting non-invasive blood pressure Korotkoff's Sound, this circuit stability is good, precision is high, Low cost, concrete technical scheme is as follows:
Extract the circuit of non-invasive blood pressure Korotkoff's Sound, as it is shown in figure 1, include pick up MIC, extract original Korotkoff's Sound audio signal;
First high pass filter, connects described pick up MIC, is less than the clutter of Korotkoff's Sound for rejection frequency;
Amplifier, connects described first high pass filter, is used for amplifying Korotkoff's Sound audio signal;
First low pass filter, connects described amplifier, is used for preventing Korotkoff's Sound audio signal aliasing;
Digital filter, connects described first low pass filter, for filtering the clutter by civil power Hz noise, is formed after extracting Korotkoff's Sound audio signal;
Second low pass filter, connects described digital filter, Korotkoff's Sound audio signal after smooth extraction;
Power amplifier, connects described second low pass filter, is used for amplifying Korotkoff's Sound audio signal;
Microphone, connects described power amplifier, for being tuned up by Korotkoff's Sound audio signal volume.
Further, as shown in Figure 4, described pick up ground connection, it is soft that described pick up MIC is connected to sphygmomanometer stethoscope end Inside pipe, described pick up connects direct current biasing resistance R1, described R1 and connects power supply.
Further, as shown in Figure 4, described first high pass filter is made up of electric capacity C1, resistance R2, resistance R3, has and puts Big and filter action so that be filtered out less than the Korotkoff's Sound audio signal of frequency f1=1/ (2 Π R2C1), make Korotkoff's Sound simultaneously Audio signal obtains gain, gain factor Gain=R3/R2.
Further, as shown in Figure 4, described amplifier negative pole connects the first high pass filter, and positive pole connects reference voltage REF, described amplifier connects power supply, described amplifier ground, and described amplifier connects electric capacity C3, electric capacity C3 ground connection.
Further, as shown in Figure 4, described first low pass filter is made up of electric capacity C4, resistance R4, C4 ground connection so that high Korotkoff's Sound audio signal in frequency f4=1/ (2 Π R4C4) is filtered out, it is achieved Korotkoff's Sound anti-aliasing.
Further, as shown in Figure 1 and Figure 2, described digital filter includes analog digital conversion ADC sampling unit, by micro-process core Sheet performs, and for Korotkoff's Sound analogue signal is converted into digital signal, forms sampled data x, defeated as IIR trap wave unit Enter;IIR trap wave unit, is used for filtering civil power Hz noise, forms trap output data y;FIR bandpass filtering unit, is used for filtering Unless Korotkoff's Sound frequency signal;Digital-to-analogue conversion DAC unit, for being converted into analogue signal by digital signal.
Further, as shown in Figure 2 and Figure 3, described IIR trap wave unit is made up of three groups of IIR trap circuits, is respectively used to filter Except civil power power frequency 50Hz, the interference of 150Hz, 250Hz, often the coefficient of group IIR trap circuit be [a0, a1, a2], [b0, b1, B2], the sampled data of input is [x0, x1, x2], and exporting data after trap is [y0, y1, y2], notch coefficient, input and defeated Below equation is met between going out:
Further, as shown in Figure 2 and Figure 3, described FIR bandpass filtering unit be frequency be 20-300 Hz, further filter out non-Ke The clutter of family name's voice frequency, the Korotkoff's Sound voice data that preservation flows through described FIR bandpass filtering unit is standby, facilitates computer to play back Analyze, it is simple to check in the future, study.
Further, as shown in Figure 4, described second low pass filter is made up of electric capacity C5, resistance R5, and C5 ground connection is used for putting down Korotkoff's Sound audio signal after sliding extraction, the signal of described second low pass filter flows through electric capacity C2 and connects power amplifier, is used for Korotkoff's Sound audio signal is increased further.
The present invention also provides for a kind of sphygomanometer, the circuit extracting non-invasive blood pressure Korotkoff's Sound described in employing so that this blood pressure Measurement accuracy of measurement is high, good stability, has preferable cost advantage, reduces small product size simultaneously, is especially suitable for being applied to wear Wear monitoring this vital sign of human blood-pressure on formula equipment.
Accompanying drawing explanation
Fig. 1 is the circuit block diagram of the present invention.
Fig. 2 is the digital filter block diagram of the present invention.
Fig. 3 is the trap block diagram of the present invention.
Fig. 4 is the circuit theory diagrams of the present invention.
Fig. 5 is the Korotkoff's Sound oscillogram after the present invention extracts.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is elaborated, it should be understood that these embodiments are only For the present invention being described rather than limiting the scope of the present invention, after having read the present invention, those skilled in the art are to this The amendment of the various equivalent form of values of invention each falls within the application claims limited range.
Embodiment 1
Extracting the circuit of non-invasive blood pressure Korotkoff's Sound, as it is shown in figure 1, include pick up MIC, pick up ground connection, pick up MIC connects Inside sphygmomanometer stethoscope end hose, being used for extracting original Korotkoff's Sound audio signal, pick up connects direct current biasing resistance R1, R1 connect power supply;
As shown in Figure 4, the first high pass filter, connect described pick up MIC, be less than the clutter of Korotkoff's Sound for rejection frequency, First high pass filter is made up of electric capacity C1, resistance R2, resistance R3, has amplification and filter action so that less than frequency f1=1/ The Korotkoff's Sound audio signal of (2 Π R2C1) is filtered out, and makes Korotkoff's Sound audio signal obtain gain, gain factor Gain=simultaneously R3/R2;
As shown in Figure 4, amplifier connects the first high pass filter, is used for amplifying Korotkoff's Sound audio signal, and amplifier negative pole connects First high pass filter, positive pole connects reference voltage REF, and amplifier connects power supply, amplifier ground, and amplifier connects electric capacity C3, electric capacity C3 ground connection;
As shown in Figure 4, the first low pass filter, connect amplifier, be used for preventing Korotkoff's Sound audio signal aliasing, the first low pass filtered Ripple device is made up of electric capacity C4, resistance R4, C4 ground connection so that filtered higher than the Korotkoff's Sound audio signal of frequency f4=1/ (2 Π R4C4) Remove, it is achieved Korotkoff's Sound anti-aliasing;
As shown in Figure 1 and Figure 2, digital filter, connect the first low pass filter, for filtering the clutter by civil power Hz noise, Forming Korotkoff's Sound audio signal after extracting, digital filter includes analog digital conversion ADC sampling unit, micro-chip processor performs, For Korotkoff's Sound analogue signal being converted into digital signal, form sampled data [x0, x1, x2], defeated as IIR trap wave unit Enter;Three groups of IIR traps, are used for filtering civil power Hz noise, often the coefficient of group IIR trap circuit be [a0, a1, a2], [b0, B1, b2], form trap output data [y0, y1, y2];FIR bandpass filtering unit, frequency is 20-300 Hz, further filters out The clutter of non-Korotkoff's Sound frequency, the Korotkoff's Sound voice data that preservation flows through described FIR bandpass filtering unit is standby, facilitates computer Recovering and analysis, it is simple to check in the future, study;Digital-to-analogue conversion DAC unit, for being converted into analogue signal by digital signal.
Notch coefficient, input and export between meet below equation:
As Figure 1 and Figure 4, the second low pass filter, connect digital filter, Korotkoff's Sound audio signal after smooth extraction, Being made up of electric capacity C5, resistance R5, C5 ground connection, the signal of the second low pass filter flows through electric capacity C2 and connects power amplifier, is used for Korotkoff's Sound audio signal is increased further;
As it is shown in figure 1, power amplifier, connect the second low pass filter, be used for amplifying Korotkoff's Sound audio signal;
As it is shown in figure 1, microphone, connect power amplifier, for being tuned up by Korotkoff's Sound audio signal volume.
As it is shown in figure 5, the Korotkoff's Sound oscillogram extracted by circuit of the present invention.
The present invention also provides for a kind of sphygomanometer, the circuit extracting non-invasive blood pressure Korotkoff's Sound described in employing so that this blood pressure Measurement accuracy of measurement is high, good stability, has preferable cost advantage, reduces small product size simultaneously, is especially suitable for being applied to wear Wear monitoring this vital sign of human blood-pressure on formula equipment.

Claims (10)

1. the circuit extracting non-invasive blood pressure Korotkoff's Sound, it is characterised in that including:
Pick up, extracts original Korotkoff's Sound audio signal;
First high pass filter, connects described pick up, is less than the clutter of Korotkoff's Sound for rejection frequency;
Amplifier, connects described first high pass filter, is used for amplifying Korotkoff's Sound audio signal;
First low pass filter, connects described amplifier, is used for preventing Korotkoff's Sound audio signal aliasing;
Digital filter, connects described first low pass filter, for filtering the clutter by civil power Hz noise, is formed after extracting Korotkoff's Sound audio signal;
Second low pass filter, connects described digital filter, Korotkoff's Sound audio signal after smooth extraction;
Power amplifier, connects described second low pass filter, is used for amplifying Korotkoff's Sound audio signal;
Microphone, connects described power amplifier, for being tuned up by Korotkoff's Sound audio signal volume.
2. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described pick up ground connection, institute Stating pick up and be connected to inside sphygmomanometer stethoscope end hose, described pick up connects direct current biasing resistance R1, described R1 even Connect power supply.
3. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described first high pass filter It is made up of electric capacity C1, resistance R2, resistance R3, there is amplification and filter action.
4. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described amplifier negative pole connects First high pass filter, positive pole connects reference voltage, and described amplifier connects power supply, described amplifier ground, described amplification Device connects electric capacity C3, electric capacity C3 ground connection.
5. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described first low pass filter It is made up of electric capacity C4, resistance R4, C4 ground connection.
6. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described digital filter includes Analog digital conversion ADC sampling unit, is performed by micro-chip processor, for Korotkoff's Sound analogue signal is converted into digital signal and right Digital signal is sampled;IIR trap wave unit, is used for filtering civil power Hz noise;FIR bandpass filtering unit, is used for filtering non- Korotkoff's Sound frequency signal;Digital-to-analogue conversion DAC unit, for being converted into analogue signal by digital signal.
7. the as claimed in claim 6 circuit extracting non-invasive blood pressure Korotkoff's Sound, it is characterised in that described IIR trap wave unit by Three groups of IIR trap circuit compositions, are respectively used to filter the interference of civil power power frequency 50Hz, 150Hz, 250Hz.
8. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 6, it is characterised in that described FIR bandpass filtering list Unit is 20-300 Hz for frequency, and the Korotkoff's Sound voice data that preservation flows through described FIR bandpass filtering unit is standby.
9. the circuit extracting non-invasive blood pressure Korotkoff's Sound as claimed in claim 1, it is characterised in that described second low pass filter Being made up of electric capacity C5, resistance R5, C5 ground connection, the signal of described second low pass filter flows through electric capacity C2 and connects power amplifier.
10. a sphygomanometer, it is characterised in that employing extraction non-invasive blood pressure Korotkoff's Sound as described in claim 1-9 is arbitrary Circuit.
CN201610546945.2A 2016-07-13 2016-07-13 Circuit for extracting non-invasive blood pressure Korotkoff's sound and sphygmomanometer Pending CN106037699A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309274A (en) * 2018-03-09 2018-07-24 上海由泰医疗器械科技有限公司 A kind of method that automatic detection obtains blood pressure Korotkoff's Sound

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473080A (en) * 1981-12-24 1984-09-25 Paavola Oiva A Blood pressure instrument
US4607641A (en) * 1983-11-04 1986-08-26 Seiko Instruments & Electronics Ltd. Electronic sphygmomanometer
US20050148885A1 (en) * 2003-08-22 2005-07-07 Eppcor, Inc. Non-invasive blood pressure monitoring device and methods
US7006638B1 (en) * 1994-08-30 2006-02-28 Bang & Olufsen Technology A/S Electronic stethoscope
CN2927986Y (en) * 2006-06-09 2007-08-01 北京麦邦光电仪器有限公司 Double method blood pressure measurer for repeatedly observation
CN101810475A (en) * 2010-04-27 2010-08-25 哈尔滨工业大学 Electronic auscultation sphygmomanometer based on combination of Korotkoff sound method and oscillometric method
CN202568230U (en) * 2012-04-20 2012-12-05 南京盟联信息科技有限公司 Korotkoff-sound sphygmomanometer
JP2015154878A (en) * 2014-02-21 2015-08-27 ミナト医科学株式会社 Sphygmomanometry device
CN206044616U (en) * 2016-07-13 2017-03-29 苏州咖丢卫私康信息科技有限公司 A kind of circuit and sphygomanometer for extracting non-invasive blood pressure Korotkoff's Sound

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473080A (en) * 1981-12-24 1984-09-25 Paavola Oiva A Blood pressure instrument
US4607641A (en) * 1983-11-04 1986-08-26 Seiko Instruments & Electronics Ltd. Electronic sphygmomanometer
US7006638B1 (en) * 1994-08-30 2006-02-28 Bang & Olufsen Technology A/S Electronic stethoscope
US20050148885A1 (en) * 2003-08-22 2005-07-07 Eppcor, Inc. Non-invasive blood pressure monitoring device and methods
CN2927986Y (en) * 2006-06-09 2007-08-01 北京麦邦光电仪器有限公司 Double method blood pressure measurer for repeatedly observation
CN101810475A (en) * 2010-04-27 2010-08-25 哈尔滨工业大学 Electronic auscultation sphygmomanometer based on combination of Korotkoff sound method and oscillometric method
CN202568230U (en) * 2012-04-20 2012-12-05 南京盟联信息科技有限公司 Korotkoff-sound sphygmomanometer
JP2015154878A (en) * 2014-02-21 2015-08-27 ミナト医科学株式会社 Sphygmomanometry device
CN206044616U (en) * 2016-07-13 2017-03-29 苏州咖丢卫私康信息科技有限公司 A kind of circuit and sphygomanometer for extracting non-invasive blood pressure Korotkoff's Sound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108309274A (en) * 2018-03-09 2018-07-24 上海由泰医疗器械科技有限公司 A kind of method that automatic detection obtains blood pressure Korotkoff's Sound

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Application publication date: 20161026