CN1060373C

CN1060373C - Drug for curing diabetes and its preparing method

Info

Publication number: CN1060373C
Application number: CN97103536A
Authority: CN
Inventors: 姚远林
Original assignee: Individual
Current assignee: Individual
Priority date: 1997-04-05
Filing date: 1997-04-05
Publication date: 2001-01-10
Anticipated expiration: 2017-04-05
Also published as: CN1195531A

Abstract

The present invention relates to a medicament for treating diabetes and a preparation method thereof, which belongs to a medicinal preparation product. The medicament is the medicinal preparation product containing raw materials, and the raw materials are mainly derived from vegetative materials. The medicament is characterized in that the medicament comprises multiple compound formulas of traditional Chinese medicine, metformin hydrochloride, gliguidone, and the compound formulas of the traditional Chinese medicine particularly have the formulas of zhucen, water plantain and phellodendron bark which respectively become compound formula carbohdraturia No. 1 A, compound formula carbohdraturia No B and compound formula carbohdraturia No. 1 C. The present invention provides serial medicines for treating diabetes and a preparation method of the serial medicines, and has the advantages of strong therapeutical effect, stable taking effect for many years, little side effect and long-term and continuous taking.

Description

A kind of medicine for the treatment of diabetes and preparation method thereof

The invention belongs to medicinal preparation.Be to contain the medicinal preparation that raw material is mainly derived from the material of plant.

The treatment diabetes use medicine for a long time that sulphanylureas (D860, glyburide, diamicron, Mei Bida, gliquidone, Gliguidone etc.) and biguanides medicines such as (phenformin, metformin etc.) are arranged.These medicines are the strongest with the effect of glyburide, phenformin, but side effect is also more obvious, as to the human liver renal damage.Because these medicines are at liver metabolism, through renal excretion mostly, so hepatic and kidney function obstacle, the ketoacidosis person uses and is restricted.Though the side effect of diamicron, gliquidone, Gliguidone etc. is lighter, its blood sugar reducing function again a little less than, clinical blood sugar control satisfactorily causes the morbidity risk rate of patient's complication to increase.Insulin is the specific medicament of treatment diabetes, no matter be I type or type, except that the insulin resistant phenomenon occurring, its hypoglycemic effect is all fabulous, but because it is inactivated in gastric acid, so can only be made into injection when using, three times on the one insulin injection makes patient often be difficult to stand the misery of adhering to long term injections.The someone uses the islets of langerhans rifle in the recent period, i.e. fast injection method, though can alleviate patient some miseries, but will inject, also be afraid of unclean infection. everydayFor the therapeutical effect that solves diabetes medicament and the contradiction of side effect, many diabetes scholars have done number of research projects, have invented the compound recipe of some treatment diabetes.Pure Chinese medicine preparation is arranged, as applicator etc.; The Chinese medicine and western medicine compound recipe is also arranged, as sugared prestige capsule etc.Though these medicines have reduced the side effect of diabetes medicament to a certain extent, its therapeutic effect is also good inadequately.

The object of the present invention is to provide a kind of therapeutical effect take by force, for many years effect stability, side effect minimum, can continue treatment diabetes medicine series of taking and preparation method thereof for a long time.

The present invention realizes with following mode: it is characterized in that pharmaceutical formulation is as follows:

Compound recipe glycosuria I A prescription:

Rhizoma Imperatae 80g Radix Clematidis 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g

Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 200

Gliquidone 30mg * 100 slice;

Compound recipe glycosuria I B prescription:

Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 60g Cortex Phellodendri 30g Rhizoma Anemarrhenae 30g

Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g metformin hydrochloride 250mg * 180

Gliquidone 30mg * 100 slice;

Compound recipe glycosuria I C prescription:

Rhizoma Imperatae 80g Typhonium flagelliforme (Lodd.) Blume 30g Cortex Phellodendri 30g Rhizoma Alismatis 30g

Polyporus 30g Radix Ginseng 50g Oryza sativa L. var. glutinosa Matsum. bud point 20g

Gliquidone 30mg * 150, metformin hydrochloride 250mg * 150 slice;

Preparation method is as follows:

1., with glutinous rice by the farming method 1.5-2cm long time of waiting to germinate of sprouting, remove empty rice husk after, pure Fructus Setariae Germinatus is dried, stir to yellow with white vinegar again, can not be sallow, the white vinegar consumption is that 100g gulch bud is converted white vinegar 5g;

2., with the Chinese medicine oven dry of respectively distinguishing the flavor of of said medicine prescription, grind the powder packing respectively;

3., the Radix Clematidis that will grind powder converts with Sal again, consumption is that every 100g Radix Clematidis is converted Sal 6g, is neither big nor small light the stir-fry to little yellow of firewood with mild and heavy respiration;

4., metformin and gliquidone are ground powder respectively;

5., above all grind powder and make after the former medicines of prescription mix thoroughly respectively by above-mentioned compound recipe glycosuria I A, B, C formula proportion, encapsulate with No. 0 capsule shells; It is 44g that per 100 capsules contain the compound recipe grain weight; Every capsules ball contains metformin 71.42mg, about three minutes a slices; Contain gliquidone 4.28mg, about seven/a slice.

Function of the present invention: QI invigorating the moon, let out the turbid worm of kidney, clots absorbing blood.Cure mainly slight, the moderate of I type, type, than the severe patient.Light moderate infringement is arranged renal function but the twenty-four-hour urine amount all can courageously be used more than 800ml patient.Therapeutical effect of the present invention is strong, and side effect is minimum; The type patient is acted on better, and the patient has certain effect to type; The light moderate infringement of hepatic and renal function patient can use; Blood circulation promoting and blood stasis dispelling is arranged, prevent the hardened function of blood capillary; There is consolidating YIN to let out that kidney is turbid, the effect of renal function protecting; Blood sugar reducing function is stablized soon; Blood fat reducing and the effect that improves blood supply of cardiac muscle are arranged.

Usage of the present invention and consumption: be grown up three times on the one, a 1-4 grain, take 20 minutes ante cibum, preferably according to the blood glucose regulation survival dose.

BS (blood glucose) 〉=14mmol/L obeys the 9-12 grain every day;

BS (blood glucose) ≈ 10mmol/L obeys the 7-9 grain every day;

BS (blood glucose) ≈ 8.3mmol/L obeys the 6-8 grain every day;

BS (blood glucose) ≈ 7.8mmol/L obeys the 5-6 grain every day;

BS (blood glucose) ≈ 5-6.7mmol/L obeys the 4-6 grain every day.

The effect of blood sugar lowering of the present invention is obvious, should just regulate dosage according to blood glucose, in order to avoid cause hypoglycemia.Diet white turnip, Folium Camelliae sinensis, Semen arachidis hypogaeae, Semen Glycines when taking medicine.Side effect of the present invention is minimum.Spontaneous remission after taking medicine 2 days when idol has nauseating phenomenon to occur.Because the characteristics on the prescription; not only the content of metformin, gliquidone is few; to little, and Rhizoma Alismatis, Polyporus, Cortex Phellodendri have on the one hand and rush down that kidney is turbid, the function of renal function protecting to hepatic and renal function influence, and medicine such as Rhizoma Alismatis, Polyporus has the function of antagonism metformin, gliquidone side effect on the other hand.So the light moderate of hepatic and renal function infull person still can use.Clinical practice effective percentage 96.4% of the present invention, obvious effective rate 79.8%.Obvious effective rate is meant that clinical symptoms is clearly better, and BS is controlled at about 7.8mmol/L, is no more than 8.3mmol/L.To the patient of long term injections insulin, after using the present invention, obviously reduce insulin dosage, the part patient is arranged even broken away from the treatment of insulin.The present invention of patient's life-time service does not find side effect.Check patient's liver function repeatedly, renal function is not seen harmful effect, hemocyte does not have downward trend, can make rate and blood-lipid decreased, and the ECG change of diabetes patient's ischemia is improved, this be because of the synergism of Typhonium flagelliforme (Lodd.) Blume, Radix Ginseng institute extremely.The long-term prescription patient does not see Drug resistance more than 3 years.Having the part patient to take 3-6 grain medicine every day can make blood glucose for a long time continually and steadily in the absolute normal district of 4.5-6.7mmol/L.

Claims

1, a kind of medicine for the treatment of diabetes is characterized in that being that pharmaceutical formulation is as follows:

No. 1 A prescription of compound recipe glycosuria:

Gliquidone 30mg * 100 slice;

No. 1 B prescription of compound recipe glycosuria:

Gliquidone 30mg * 100 slice;

No. 1 C prescription of compound recipe glycosuria:

Gliquidone 30mg * 150, metformin hydrochloride 250mg * 150 slice;

2, the preparation method of the described medicine of claim 1 is characterized in that preparation method is as follows:

1., with glutinous rice by the farming method 1.5-2cm long time of waiting to germinate of sprouting, remove empty rice husk, pure Fructus Setariae Germinatus is dried, stir to yellow with white vinegar again, can not be sallow, the white vinegar consumption is that every 100g gulch bud is converted white vinegar 5g;

2., with the Chinese medicine oven dry of respectively distinguishing the flavor of in the above-mentioned prescription drug, grind the powder packing respectively;

4., metformin and gliquidone are ground powder respectively;

5., above all grind powder and make after the former medicines of prescription mix thoroughly respectively by above-mentioned compound recipe glycosuria No. 1 A, B, C formula proportion, encapsulate with No. 0 capsule shells; It is 44g that per 100 capsules contain the compound recipe grain weight, and every capsules ball contains metformin 71.42mg, about three/a slice; Contain gliquidone 4.28mg, about seven/a slice.