CN106008697B - 纯化vwf以增加非-脂质包封的病毒的去除 - Google Patents
纯化vwf以增加非-脂质包封的病毒的去除 Download PDFInfo
- Publication number
- CN106008697B CN106008697B CN201610190778.2A CN201610190778A CN106008697B CN 106008697 B CN106008697 B CN 106008697B CN 201610190778 A CN201610190778 A CN 201610190778A CN 106008697 B CN106008697 B CN 106008697B
- Authority
- CN
- China
- Prior art keywords
- cation exchange
- exchange resin
- protein
- vwf
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23557009P | 2009-08-20 | 2009-08-20 | |
US61/235,570 | 2009-08-20 | ||
CN2010800395824A CN102482341A (zh) | 2009-08-20 | 2010-08-20 | 纯化vwf以增加非-脂质包封的病毒的去除 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800395824A Division CN102482341A (zh) | 2009-08-20 | 2010-08-20 | 纯化vwf以增加非-脂质包封的病毒的去除 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106008697A CN106008697A (zh) | 2016-10-12 |
CN106008697B true CN106008697B (zh) | 2020-08-04 |
Family
ID=43063204
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610190778.2A Active CN106008697B (zh) | 2009-08-20 | 2010-08-20 | 纯化vwf以增加非-脂质包封的病毒的去除 |
CN2010800395824A Pending CN102482341A (zh) | 2009-08-20 | 2010-08-20 | 纯化vwf以增加非-脂质包封的病毒的去除 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800395824A Pending CN102482341A (zh) | 2009-08-20 | 2010-08-20 | 纯化vwf以增加非-脂质包封的病毒的去除 |
Country Status (18)
Country | Link |
---|---|
US (1) | US9315560B2 (zh) |
EP (1) | EP2467399B2 (zh) |
JP (1) | JP5838159B2 (zh) |
KR (1) | KR101894600B1 (zh) |
CN (2) | CN106008697B (zh) |
AU (1) | AU2010284116B9 (zh) |
BR (1) | BR112012003802B1 (zh) |
CA (1) | CA2771232A1 (zh) |
DK (1) | DK2467399T3 (zh) |
ES (1) | ES2562256T5 (zh) |
HU (1) | HUE026907T2 (zh) |
IN (1) | IN2012DN01849A (zh) |
MX (1) | MX2012002129A (zh) |
NZ (1) | NZ598249A (zh) |
PL (1) | PL2467399T3 (zh) |
PT (1) | PT2467399E (zh) |
SG (2) | SG10201408106WA (zh) |
WO (1) | WO2011022657A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
BRPI0919693A2 (pt) | 2008-10-21 | 2020-08-11 | Baxter Healthcare S.A | formulação farmacêutica estável liofilizada |
CN104640969A (zh) * | 2012-06-21 | 2015-05-20 | 巴克斯特国际公司 | 细胞培养基的病毒过滤 |
JP6320429B2 (ja) * | 2013-02-22 | 2018-05-09 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | 負帯電粒子を用いるウイルス調製物のクロマトグラフィー精製 |
DK3360895T3 (da) * | 2014-06-06 | 2021-11-15 | Octapharma Ag | Præparat omfattende faktor-viii og von-willebrand-faktor-peptider |
CN106414719B (zh) | 2014-06-13 | 2020-02-14 | 杰特有限公司 | 生物反应器中重组von Willebrand因子的改进生产 |
CN110997015A (zh) | 2017-08-23 | 2020-04-10 | 德国杰特贝林生物制品有限公司 | 用于von Willebrand因子的病毒过滤的方法 |
US10934340B2 (en) | 2018-03-21 | 2021-03-02 | Baxalta Incorporated | Separation of VWF and VWF propeptide by chromatographic methods |
WO2023170680A1 (en) | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1191545A (zh) * | 1995-05-25 | 1998-08-26 | 达尔塔生物工艺有限公司 | 高***蛋白生产方法 |
CN101333244A (zh) * | 1998-05-06 | 2008-12-31 | 基因技术股份有限公司 | 用离子交换层析纯化蛋白质 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
WO1986006096A1 (en) | 1985-04-11 | 1986-10-23 | The Children's Medical Center Corporation | Von willebrand factor |
AT405403B (de) * | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
AT406373B (de) * | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
AT405485B (de) | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
US6531577B1 (en) † | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
DK1835938T3 (da) | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand-faktor-konjugater |
-
2010
- 2010-08-20 WO PCT/US2010/046180 patent/WO2011022657A1/en active Application Filing
- 2010-08-20 NZ NZ598249A patent/NZ598249A/en unknown
- 2010-08-20 ES ES10747134T patent/ES2562256T5/es active Active
- 2010-08-20 BR BR112012003802-8A patent/BR112012003802B1/pt active IP Right Grant
- 2010-08-20 KR KR1020127005935A patent/KR101894600B1/ko active IP Right Grant
- 2010-08-20 US US12/860,501 patent/US9315560B2/en active Active
- 2010-08-20 IN IN1849DEN2012 patent/IN2012DN01849A/en unknown
- 2010-08-20 HU HUE10747134A patent/HUE026907T2/en unknown
- 2010-08-20 MX MX2012002129A patent/MX2012002129A/es active IP Right Grant
- 2010-08-20 AU AU2010284116A patent/AU2010284116B9/en active Active
- 2010-08-20 CA CA2771232A patent/CA2771232A1/en active Pending
- 2010-08-20 PT PT107471344T patent/PT2467399E/pt unknown
- 2010-08-20 PL PL10747134T patent/PL2467399T3/pl unknown
- 2010-08-20 EP EP10747134.4A patent/EP2467399B2/en active Active
- 2010-08-20 JP JP2012525731A patent/JP5838159B2/ja active Active
- 2010-08-20 CN CN201610190778.2A patent/CN106008697B/zh active Active
- 2010-08-20 SG SG10201408106WA patent/SG10201408106WA/en unknown
- 2010-08-20 CN CN2010800395824A patent/CN102482341A/zh active Pending
- 2010-08-20 SG SG2012011177A patent/SG178478A1/en unknown
- 2010-08-20 DK DK10747134.4T patent/DK2467399T3/en active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1191545A (zh) * | 1995-05-25 | 1998-08-26 | 达尔塔生物工艺有限公司 | 高***蛋白生产方法 |
CN101333244A (zh) * | 1998-05-06 | 2008-12-31 | 基因技术股份有限公司 | 用离子交换层析纯化蛋白质 |
Non-Patent Citations (1)
Title |
---|
The removal of model viruses, Poliovirus type 1 and Canine Parvovirus, during the purification of human albumin using ion-exchange chromatographic procedures;Rachel Cameron et al.;《Journal of the international association of biological standardization》;19971231;第25卷(第4期);391-401 * |
Also Published As
Publication number | Publication date |
---|---|
AU2010284116B2 (en) | 2015-02-12 |
US20110092681A1 (en) | 2011-04-21 |
ES2562256T5 (es) | 2023-07-20 |
JP5838159B2 (ja) | 2015-12-24 |
SG178478A1 (en) | 2012-04-27 |
NZ598249A (en) | 2014-04-30 |
DK2467399T3 (en) | 2017-01-23 |
EP2467399A1 (en) | 2012-06-27 |
IN2012DN01849A (zh) | 2015-08-21 |
BR112012003802A2 (pt) | 2016-11-22 |
EP2467399B2 (en) | 2023-02-01 |
ES2562256T3 (es) | 2016-03-03 |
CN106008697A (zh) | 2016-10-12 |
HUE026907T2 (en) | 2016-07-28 |
KR101894600B1 (ko) | 2018-09-03 |
WO2011022657A1 (en) | 2011-02-24 |
AU2010284116B9 (en) | 2015-03-26 |
PL2467399T3 (pl) | 2016-05-31 |
KR20120065342A (ko) | 2012-06-20 |
CA2771232A1 (en) | 2011-02-24 |
MX2012002129A (es) | 2012-06-08 |
SG10201408106WA (en) | 2015-01-29 |
AU2010284116A1 (en) | 2012-03-08 |
US9315560B2 (en) | 2016-04-19 |
EP2467399B1 (en) | 2015-11-11 |
BR112012003802B1 (pt) | 2022-10-25 |
JP2013502434A (ja) | 2013-01-24 |
CN102482341A (zh) | 2012-05-30 |
PT2467399E (pt) | 2016-03-18 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20170816 Address after: Illinois State Applicant after: Hundred deep company Applicant after: Hundred deep limited liability company Address before: Illinois State Applicant before: Baxter International Inc. Applicant before: Bakst Helth Co., Ltd. |
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Effective date of registration: 20210721 Address after: Osaka Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd. Address before: Illinois, USA Patentee before: Baishen Co. Patentee before: BAXALTA GmbH |