CN105999059A - Natural plant type anticancer medicine composition, preparation and preparation method thereof - Google Patents
Natural plant type anticancer medicine composition, preparation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a natural plant type anticancer medicine composition, a preparation and a preparation method thereof. The anticancer medicine composition includes: Chinese gooseberry root, hedyotis diffusa, loquat leaf, wild chrysanthemum, lance asiabell root, corium bufonis, Arisaema, charred nodus nelumbinis rhizomatis, humus flava usta, huangchuan powder, stigma croci, brucea amarissima and zedoary. The preparation is prepared by using the above-mentioned anticancer medicine composition as the active material. The raw material power is covered with organic fat, detoxicated under high temperature, cooled and polymerized at low temperature, and crushed to obtain a solid preparation. The solid preparation and myohemoglobin are steamed with isolation from water, and filtered to obtain a liquid preparation of decoction. The above drugs are combined to strengthen body resistance, eliminate evil, enhance immune regulation, strengthen and improve microcirculation, and enhance immune surveillance through chest protection and immune improvement; the preparation induces cancer cell apoptosis or reversal, dissipates blood stasis to relieve pain, evacuates cell aggregation, makes the cancer cells hard to survive or eliminate the internal or external conditions necessary for cancer cells generation. The whole treatment process has no toxic or side effect.
Description
Technical field
The present invention relates to cancer therapy drug technical field, particularly relate to a kind of natural plant kind anticancer pharmaceutical composition, preparation
And preparation method thereof.
Background technology
Over more than 100 year, the mankind treatment cancer course in invented operation, radiotherapy, chemotherapy, intervention, immunity, with poison
The therapies such as counteracting toxic substances, nourishing righting.The main poisonous tumoricidal chemotherapeutic of cancer therapy drug and the Chinese medicine for the treatment of the poisonous disease with poisonous drugs, both
It is one " double-edged sword ", had both killed cancerous cell and also killed normal cell that infringement human organ and hemopoietic function cause alopecia, tight
Weight anemia, digestive functional disturbance and damnification of immunity function etc..These methods and medicine all can not the most effectively solve cancer
Treatment, more can not solve the technical problem of extract drugs and efficient combination, the Preventive of cancer and immunologic function serious
Impaired is all to cause main causes of death.
Summary of the invention
For drawbacks described above and the problem of prior art, it is an object of the invention to provide a kind of natural plant kind cancer therapy drug
Compositions, preparation and preparation method thereof.According to " Plain Questions ", big poison is cured the disease, mild toxicity is cured the disease, normal poison is cured the disease and nontoxic cures the disease curative effect not
The enlightenment of disconnected extension, the cancer therapy drug after it is an object of the invention to poisonous natural plant kind medicine attenuation carries out organic assembling
After, and make targeting medicine further, the cell reversal of sudden change can be made and stop amplification and the transfer of cancerous tumor cell, thus effectively
The generation preventing cancer and the relapse and metastasis of tumor, whole process of taking does not injures normal structure and cell, is to current cancer
What disease treatment non-target tropism was not enough supplements and development.Solve anti cancer target Biotechnological issues the most accurately.
In order to achieve the above object, the present invention provides following technical scheme:
A kind of natural plant kind anticancer pharmaceutical composition, by weight, including following raw material: Radix Actinidiae Chinensis 8-15 part, spend in vain
Herba Hedyotidis Diffusae 10-15 part, Folium Eriobotryae 5-10 part, Flos Chrysanthemi Indici 3-10 part, Radix Codonopsis lanceolatae 5-10 part, dry maxima skin 3-10 part, Rhizoma Arisaematis 3-10
Part, charred Nodus Nelumbinis Rhizomatis 5-10 part, Terra Flava Usta 8-15 part, yellow river powder (Zijin whip) 10-20 part, Stigma Croci 3-10 part, Fructus Bruceae 3-8 part and
Rhizoma Curcumae 5-10 part.
Preferably, by weight, described anticancer pharmaceutical composition includes following raw material: Radix Actinidiae Chinensis 10 parts, Herba Hedyotidis Diffusae
12 parts, Folium Eriobotryae 8 parts, Flos Chrysanthemi Indici 6 parts, Radix Codonopsis lanceolatae 8 parts, dry maxima skin 6 parts, Rhizoma Arisaematis 6 parts, charred Nodus Nelumbinis Rhizomatis 8 parts, Terra Flava Usta 10 parts,
Yellow river powder (Zijin whip) 16 parts, Stigma Croci 6 parts, Fructus Bruceae 6 parts and Rhizoma Curcumae 8 parts.
The natural plant kind anti-cancer drug preparation of the present invention, is to combine with the natural plant kind cancer therapy drug of the invention described above
Thing is that activated feedstock prepares.
Described anti-cancer drug preparation is solid preparation or liquid formulation.
The preparation method of the natural plant kind anti-cancer drug preparation of the present invention, comprises the following steps:
Step one, according to above-mentioned anticancer pharmaceutical composition component prepare each raw material, each raw mill is become powder；So
After weigh each material powder according to the consumption of each raw material, and each material powder is mixed, obtains mixed-powder；
Step 2, by the mixed-powder of step one with alicyclic organic embed, obtain pre-treatment substance；Pre-treatment substance is heated to
After temperature higher than 300 DEG C, obtain high temperature except the pre-treatment substance after poison；Again high temperature is positioned below except the pre-treatment substance after poison
The low temperature environment of subzero 20 DEG C cools down, pulverizes concentration the most again, obtain the anti-cancer drug preparation of pressed powder agent.
Preferably, in step 2, after pre-treatment substance is heated to the temperature of 320 DEG C-360 DEG C, obtain high temperature except after poison
Pre-treatment substance；Again high temperature is placed in the low temperature environment of subzero 25 DEG C-subzero 30 DEG C cooling except the pre-treatment substance after poison.
Further preferred technical scheme is, adds in the anti-cancer drug preparation of pressed powder agent step 2 prepared
Enter corresponding solid dosage forms adjuvant, prepare the anti-cancer drug preparation of corresponding solid dosage forms.
Such as, the anti-cancer drug preparation of solid dosage forms can also is that tablet, pill, granule and capsule etc..
Further preferred technical scheme is, also includes the anti-cancer drug preparation of the pressed powder agent utilizing step 2 to obtain
Prepare the step 3 of liquid formulation, obtain liquid formulation.
Further, the concrete operations of step 3 are as follows: the anti-cancer drug preparation of the pressed powder agent that step 2 is obtained,
Myoglobin and water mix homogeneously obtain mixture, mixture is carried out water proof and steams, and filter, take filtrate, obtain liquid formulation；Its
In, the anti-cancer drug preparation of pressed powder dosage form and the mass ratio of Myoglobin are 1 5-10.
Specifically, described Myoglobin directly uses the meat of mammal.As, pig tenterloin lean meat, shin beef etc..Tool
Body consumption carries out converting according to the content of Myoglobin in the actual meat used.
Preferably, the anti-cancer drug preparation of pressed powder dosage form and the mass ratio of Myoglobin are 1 7-8.
Further, the volume of water is 15-20ml 1g with the ratio of the quality of Myoglobin.It is preferably, 16ml 1g.
Further, also added flavouring agent, e.g., Sal, Rhizoma Zingiberis Recens etc. in mixture, its consumption determines according to actual demand
?.
Further, the process of steaming is: steam after opening, then insulation steams 10-20min.
The liquid formulation prepared through above-mentioned steps three can directly be taken, it is also possible to using this liquid formulation as activity
Composition, after adding corresponding liquid forms adjuvant, is made as the anti-cancer drug preparation of corresponding liquid forms.Such as, syrup,
Oral solutions etc..
Effect and effect of Chinese medicine in the natural plant kind anticancer pharmaceutical composition of the present invention are as follows:
Radix Actinidiae Chinensis: heat-clearing and toxic substances removing, anticancer, anti-inflammatory analgetic, diuresis.Cure mainly: cancer.Among the people also it is commonly used to nourishing and fit keeping function, life
Tianjin profit is dry.
Herba Hedyotidis Diffusae: sweet in the mouth, cold.Function cures mainly: heat-clearing and toxic substances removing, eliminating damp-heat, main dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, water
Swollen, jaundice due to damp-heat, cancerous protuberance etc..Modern study tool antitumor, anti-inflammation and immunoregulation effect, increase cytophagous phagocytosis
Ability, strengthens the cytotoxic T cell killing rate to target cell (cancerous cell).
Folium Eriobotryae: bitter in the mouth, property is put down.Effect: clearing away lung-heat to relieve cough, cures mainly: heat clearing away is coughed, and QI rising in reverse order is panted.
Rhizoma Curcumae: pungent, bitter, temperature.Effect: removing blood stasis circulation of qi promoting, reducing swelling and alleviating pain.
Flos Chrysanthemi Indici: nature and flavor are bitter, pungent, are slightly cold.Return lung.Function heat-clearing and toxic substances removing.It is mainly used in carbuncle, furunculosis, laryngopharynx swelling and pain.
Stigma Croci: sweet in the mouth is put down.Function cures mainly: blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving, is used for treating that chest and diaphragm painful abdominal mass is vexed, blood stasis
Have a pain.
Radix Codonopsis lanceolatae: Gan Xin is flat.Function cures mainly: detumescence, removing toxic substances, and evacuation of pus is eliminated the phlegm.Control lung abscess, toxic swelling, scrofula, throat moth, taste
Pungent, nontoxic.
Dry maxima skin: pungent, cool is poisonous.Return lung meridian.Function with cure mainly: broken knot, the infantile malnutrition that disappears, Hang Shui, removing toxic substances, parasite killing, analgesic therapy.
Rhizoma Arisaematis: bitter, pungent, temperature；Poisonous.Function with cure mainly: drying dampness to eliminate phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating.Cough for pertinacious phlegm
Coughing, middle wind-phlegm is stopped up.
Charred Nodus Nelumbinis Rhizomatis: sweet, puckery is flat.Return lung meridian.Function: astringing to arrest bleeding.Cure mainly: spit blood, spitting of blood etc..
Terra Flava Usta: pungent, temperature.Function cures mainly: warming middle-JIAO dampness, hemostasis, carbuncle ulcer.
Yellow river powder: primary efficacy: heat-clearing and toxic substances removing, sterilization eliminating stagnation, the hard removing blood stasis with potent drugs that disappears, diuresis are relieved oedema or abdominal distension through diuresis or purgation, relieving cough and resolving phlegm, rush down lower logical
Just, wind expelling stagnation removing.Its pharmacological action is: bactericidal, anticancer press down cancer, diuresis promoting.
Fructus Bruceae, calls Semen Sophorae Flavescentis.Its nature and flavor bitter cold, slightly poisonous.Can be with heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving；External corrosion is superfluous
Wart.It is usually used in dysentery, malaria；External treatment wart, clavus.
The natural plant kind anti-cancer drug preparation of the present invention belongs to green anticancer component, and the drug effect of each composition complements each other,
Dominant mechanism is by dredging energy and blood of human body, clear stasis and resolving masses, regulates blood and improve microcirculation in human body and microenvironment, and removing it has
Evil free radical, the negative oxygen ion of tax abundance and the element mutually affine with cancerous cell DNA structure, thus the generation of effective prophylaxis of cancer
With the relapse and metastasis of suppression tumor, incorporate modern biotechnology albumen simultaneously and embed into targeting substance and go directly cancerous cell so that it is cancer
Gene is suppressed, tumor thus terminate growth and breeding, this is effectively supplementing current cancer chemotherapy targeted therapy wretched insufficiency.
According to modern medicine, cancer basic research (development and transfer occur) is deepened continuously, real by clinical treatment
Trampling, the generation development of cancer and relapse and metastasis are in addition to the biological characteristics of cancerous cell self, it is important that with the immunologic function of people
Sound and blood circulation have close relationship, the interior environment of cancer run exactly smooth, metabolism is smooth, immune surveillance merit
Can be not enough, simultaneously its cell in mutation process also with the generation of controlled or non-controllable inflammation.These the most all give cancerous cell
Growth create favorable conditions, according to the special environment of growth of cancer cells and condition (be afraid of high temperature, be afraid of cold, anaerobism, fearness alkaline and
Hobby sour environment).In the prescription of the present invention, Radix Actinidiae Chinensis Stigma Croci etc. can righting, strengthen body's immunity, particularly improve
T cell and the function of NK cell；Herba Hedyotidis Diffusae, yellow river powder etc. have heat-clearing and toxic substances removing, sterilization eliminating stagnation, clearly heavily fortified point removing blood stasis with potent drugs, increase gulp down
Phagocytal phagocytic function；Stigma Croci can promote the generation of hemoglobin erythrocyte and leukocyte, activates the activity of hemocyte, produces
Raw negative oxygen ion removes free radical；Terra Flava Ustas etc. have releasing negative oxygen ion, an activated water molecule, improve cell oxygen carrying capacity, clear
Except toxic gene (antioxidation), improve microcirculation, there is good antitumor action；Above-mentioned prescription is aided with modern biotechnology protein
Embedding techniques so that it is medical substance goes directly focus and cancerous cell so that it is targeting, in cancerous tissue, has no side effect, and is
Targeted therapy accurately.Above four groups of medicine synergy, reach strengthening vital QI to eliminate pathogenic factors, strengthen immunologic function, regulate and improve microcirculation
Effect, exempted from by chest protector liter simultaneously, promote immune surveillance, induction Denucleation or apoptosis, eliminating stasis to stop pain, evacuate cell and gather
Collection, makes cancerous cell cannot survive or eliminate its requisite interiorly or exteriorly condition generated.The more important thing is whole treatment
Process is without any side effects.
In the preparation method of the natural plant kind anti-cancer drug preparation of the present invention, it is polymerized except poison and sub-cooled by high temperature
The process means of combination, the toxicity of component in compositions (especially tourmaline) is thoroughly removed, it is ensured that prepare
Having no side effect of natural plant kind anti-cancer drug preparation.Therefore, the natural plant kind anti-cancer drug preparation of the present invention can claim
Disappear for ice fire targeting and control tumor cancer therapy drug.
Detailed description of the invention
Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described, it is clear that
Described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based on the enforcement in the present invention
Example, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into
The scope of protection of the invention.
The weight portion of the natural plant kind anticancer pharmaceutical composition of the present invention benchmark consistent, can be 1g, 1kg, or
Person 10g.Below on the basis of every weight portion is as 10g, natural plant kind anticancer pharmaceutical composition and the preparation thereof of the present invention is described.
Embodiment 1
The natural plant kind anticancer pharmaceutical composition of the present embodiment 1, by weight, described anticancer pharmaceutical composition include with
Lower raw material: Radix Actinidiae Chinensis 100g, Herba Hedyotidis Diffusae 120g, Folium Eriobotryae 80g, Flos Chrysanthemi Indici 60g, Radix Codonopsis lanceolatae 80g, dry maxima skin 60g, raw south
Star 60g, charred Nodus Nelumbinis Rhizomatis 80g, Terra Flava Usta 100g, yellow river powder (Zijin whip) 160g, Stigma Croci 60g, Fructus Bruceae 60g and Rhizoma Curcumae 80g.
The natural plant kind anti-cancer drug preparation of the present embodiment 1, is with anticancer pharmaceutical composition described above as activity
The anti-cancer drug preparation of the pressed powder agent that raw material prepares.
Specifically, the preparation method of the anti-cancer drug preparation of pressed powder agent, comprise the following steps:
Step one, according to above-mentioned anticancer pharmaceutical composition component prepare each raw material, each raw mill is become powder；So
After weigh each material powder according to the consumption of each raw material, and each material powder is mixed, obtains mixed-powder；
Step 2, by the mixed-powder of step one with alicyclic organic embed, obtain pre-treatment substance；Pre-treatment substance is heated to
After temperature higher than 300 DEG C (e.g., 320 DEG C-360 DEG C), obtain high temperature except the pre-treatment substance after poison；Again by pre-except after poison of high temperature
Treated substance is positioned below in the low temperature environment of subzero 20 DEG C (e.g., subzero 25 DEG C-subzero 30 DEG C) cooling, pulverizes dense the most again
Contracting, obtains the anti-cancer drug preparation of pressed powder agent.
The anti-cancer drug preparation of the pressed powder agent in the present embodiment 1 can directly be taken, it is also possible to it for main one-tenth
Point, add corresponding solid dosage forms adjuvant, prepare the anti-cancer drug preparation of corresponding solid dosage forms.As, tablet, pill,
Granule and capsule etc..
Taking dose is the anti-cancer drug preparation of each 6g effective pressed powder agent.
Embodiment 2
The present embodiment 2 is on the basis of the anti-cancer drug preparation of the pressed powder agent of above-described embodiment 1, is made as
The cancer therapy drug of liquid formulation.Concrete operations are as follows: take the pressed powder that the step 2 in the preparation method of 6g embodiment 1 obtains
The anti-cancer drug preparation of agent, 50g pig tenterloin lean meat minced meat (content of Myoglobin is 80%-90%) and 100ml water are put into
In container (e.g., china bowl), mix homogeneously obtains mixture, puts on the steaming tray of steamer by the china bowl containing mixture, carries out water proof
Steam, steam after opening, then moderate heat insulation steams 15min, filters, takes filtrate, obtain the anti-cancer drug preparation of the liquid formulation of decoction.
The amount of the anti-cancer drug preparation of the liquid formulation of the decoction that the present embodiment 2 obtains is 80-100ml.
Preferably, according to the taste of user, appropriate flavouring agent, e.g., Sal, Rhizoma Zingiberis Recens etc. can be added in the mixture.
Specifically, in the present embodiment 2,1-2g Rhizoma Zingiberis Recens and a little Sal (e.g., 1g) can be added.
Dose is the anti-cancer drug preparation of the liquid formulation of the above-mentioned decoction prepared of each 100ml.
Embodiment 3
The natural plant kind anticancer pharmaceutical composition of the present embodiment 3, by weight, described anticancer pharmaceutical composition include with
Lower raw material: Radix Actinidiae Chinensis 80g, Herba Hedyotidis Diffusae 100g, Folium Eriobotryae 50g, Flos Chrysanthemi Indici 30g, Radix Codonopsis lanceolatae 50g, dry maxima skin 30g, raw south
Star 30g, charred Nodus Nelumbinis Rhizomatis 50g, Terra Flava Usta 80g, yellow river powder (Zijin whip) 100g, Stigma Croci 30g, Fructus Bruceae 30g and Rhizoma Curcumae 50g.
The natural plant kind anti-cancer drug preparation of the present embodiment 3, is to be with above-mentioned natural plant kind anticancer pharmaceutical composition
Solid preparation that activated feedstock prepares or the anti-cancer drug preparation of liquid preparation.
Wherein, the preparation method of the anti-cancer drug preparation of solid preparation, comprise the following steps:
Step one, according to above-mentioned anticancer pharmaceutical composition component prepare each raw material, each raw mill is become powder；So
After weigh each material powder according to the consumption of each raw material, and each material powder is mixed, obtains mixed-powder；
Step 2, by the mixed-powder of step one with alicyclic organic embed, obtain pre-treatment substance；Pre-treatment substance is heated to
After temperature higher than 300 DEG C (e.g., 320 DEG C-360 DEG C), obtain high temperature except the pre-treatment substance after poison；Again by pre-except after poison of high temperature
Treated substance is positioned below in the low temperature environment of subzero 20 DEG C (e.g., subzero 25 DEG C-subzero 30 DEG C) cooling, pulverizes dense the most again
Contracting, obtains the anti-cancer drug preparation of pressed powder agent.
The anti-cancer drug preparation of the pressed powder agent in the present embodiment 3 can directly be taken, it is also possible to it for main one-tenth
Point, add corresponding solid dosage forms adjuvant, prepare the anti-cancer drug preparation of corresponding solid dosage forms.As, tablet, pill,
Granule and capsule etc..Dose is the anti-cancer drug preparation of the pressed powder agent of each 6g effective ingredient.
The preparation method of the anti-cancer drug preparation of the liquid formulation of the present embodiment 3 is as follows: to take what 6g above-mentioned steps two obtained
The anti-cancer drug preparation of pressed powder agent, 50g pig tenterloin lean meat minced meat (content of Myoglobin is 80%-90%) and
100ml water is put in container (e.g., china bowl), and mix homogeneously obtains mixture, and the china bowl containing mixture is put into the steaming tray of steamer
On, carry out water proof and steam, steam after opening, then moderate heat insulation steams 15min, filters, takes filtrate, obtain the soup that volume is 80-100ml
The anti-cancer drug preparation of the liquid formulation of agent.
Preferably, according to the taste of user, appropriate flavouring agent, e.g., Sal, Rhizoma Zingiberis Recens etc. can be added in the mixture.
Specifically, in the present embodiment 2,1-2g Rhizoma Zingiberis Recens and a little Sal (e.g., 1g) can be added.
The anti-cancer drug preparation of the liquid formulation of the decoction that the present embodiment 3 obtains can directly be taken, it is also possible to this liquid
State preparation, as active component, after adding corresponding liquid forms adjuvant, is made as the cancer therapy drug system of corresponding liquid forms
Agent.Such as, syrup, oral solutions etc..Dose is the anticancer of the liquid formulation of the above-mentioned decoction prepared of each 100ml
Pharmaceutical preparation.
Embodiment 4
The natural plant kind anticancer pharmaceutical composition of the present embodiment 4, by weight, described anticancer pharmaceutical composition include with
Lower raw material: Radix Actinidiae Chinensis 150g, Herba Hedyotidis Diffusae 150g, Folium Eriobotryae 100g, Flos Chrysanthemi Indici 100g, Radix Codonopsis lanceolatae 100g, dry maxima skin 100g,
Rhizoma Arisaematis 100g, charred Nodus Nelumbinis Rhizomatis 100g, Terra Flava Usta 150g, yellow river powder (Zijin whip) 200g, Stigma Croci 100g, Fructus Bruceae 80g and cowherb
Art 100g.
The natural plant kind anti-cancer drug preparation of the present embodiment 4, is to be with above-mentioned natural plant kind anticancer pharmaceutical composition
Solid preparation that activated feedstock prepares or the anti-cancer drug preparation of liquid preparation.
Wherein, the preparation method of the anti-cancer drug preparation of solid preparation, comprise the following steps:
Step one, according to above-mentioned anticancer pharmaceutical composition component prepare each raw material, each raw mill is become powder；So
After weigh each material powder according to the consumption of each raw material, and each material powder is mixed, obtains mixed-powder；
Step 2, by the mixed-powder of step one with alicyclic organic embed, obtain pre-treatment substance；Pre-treatment substance is heated to
After temperature higher than 300 DEG C (e.g., 320 DEG C-360 DEG C), obtain high temperature except the pre-treatment substance after poison；Again by pre-except after poison of high temperature
Treated substance is positioned below in the low temperature environment of subzero 20 DEG C (e.g., subzero 25 DEG C-subzero 30 DEG C) cooling, pulverizes dense the most again
Contracting, obtains the anti-cancer drug preparation of pressed powder agent.
The anti-cancer drug preparation of the pressed powder agent in the present embodiment 4 can directly be taken, it is also possible to it for main one-tenth
Point, add corresponding solid dosage forms adjuvant, prepare the anti-cancer drug preparation of corresponding solid dosage forms.As, tablet, pill,
Granule and capsule etc..Dose is the anti-cancer drug preparation of the pressed powder agent of each 6g effective ingredient.
The preparation method of the anti-cancer drug preparation of the liquid formulation of the present embodiment 4 is as follows: to take what 6g above-mentioned steps two obtained
The anti-cancer drug preparation of pressed powder agent, 50g pig tenterloin lean meat minced meat (content of Myoglobin is 80%-90%) and
100ml water is put in container (e.g., china bowl), and mix homogeneously obtains mixture, and the china bowl containing mixture is put into the steaming tray of steamer
On, carry out water proof and steam, steam after opening, then moderate heat insulation steams 15min, filters, takes filtrate, obtain the soup that volume is 80-100ml
The anti-cancer drug preparation of the liquid formulation of agent.
Preferably, according to the taste of user, appropriate flavouring agent, e.g., Sal, Rhizoma Zingiberis Recens etc. can be added in the mixture.
Specifically, in the present embodiment 2,1-2g Rhizoma Zingiberis Recens and a little Sal (e.g., 1g) can be added.
The anti-cancer drug preparation of the liquid formulation of the decoction that the present embodiment 4 obtains can directly be taken, it is also possible to this liquid
State preparation, as active component, after adding corresponding liquid forms adjuvant, is made as the cancer therapy drug system of corresponding liquid forms
Agent.Such as, syrup, oral solutions etc..Dose is the liquid formulation of the most above-mentioned decoction prepared of each 100ml
Anti-cancer drug preparation.
The invention provides following clinical practice example:
Clinical practice example 1
King XX, man, 61 years old, Shaoyang, Hunan nationality, patient 2015.05 was diagnosed as through chest and head CT inspection in Xiang Ya hospital
Primary lung cancer companion's brain metastes.Cardinal symptom: cough, expectoration, expectorant is white, thickness, is difficult to expectoration, with left side breast during cough
Bitterly；Left side head distending pain, with vomiting time violent, right side upper arm and scapular region pain, when right side upper limb is praised, pain increases the weight of.,
CEA 171ug/L, CA125 184Ku/L.2015-10-03 starts to take the ice fire target of the oral liquid of the decoction of above-described embodiment 2
To the control tumor medicine that disappears, a 100ML, every twice-daily；After three months, decrement is to once a day, and 2016-04-03 decrement was to every three days
Once, and adhere to taking so far.Patient's mind is clear at present, in high spirits, and without obvious cough and expectoration, left side head distending pain disappears, right
Side upper arm and scapular region pain substantially alleviate when being relatively admitted to hospital, and when right side upper limb is praised, pain disappears.CEA 71ug/L, CA125
104Ku/L。
Clinical practice example 2
Relax XX, man, 60 years old, Chongqing nationality.Patient on October 14th, 2015 great Ping hospital of Third Military Medical University be diagnosed as " lung
Cancer (superior lobe of right lung peripheral) companion lymph metastasis, right pleural effusion, whole body many places Bone tumour.Cardinal symptom has: cough, expectoration
And sputum mixed with blood, right side supraclavicular fossa lymph node swells and ache, omoplate district, right side pain, right side chest pain；Look into CA15 196u/L, ferrum egg
White 686.7ug/L, does not gives operation and chemicotherapy.Start to take the ice fire of the oral liquid of above-described embodiment 2 on October 27th, 2015
Targeting disappears control tumor medicine, a 100ML, every twice-daily；After three months, decrement is to once a day, 2016-05-01 decrement to every two
It once and adheres to taking so far, and current patient mental is in good condition, and diet, sleep normally, occasionally have cough, cough a small amount of white bubble
Expectorant, sputum mixed with blood disappears, and the lymph node of right side supraclavicular fossa enlargement disappears, and omoplate district, right side and right side chest pain pain are alleviated；
2016-04-28 checks CA15 42u/L, ferritin 246.7ug/L, and chest and back pain disappears；Check CEA, etc. tumor markers equal
The most normal.
Clinical practice case 3
Zhai XX, man, Darlag county nationality, pulmonary carcinoma (left).Patient in 2014-08 in Affiliated Hospital of Qinghai University through lung CT
And puncture disease inspection is diagnosed as: left adenocarcinoma of lung；Chemotherapy 20 times, 2015-03 starts occur that tumor markers rises, check CT prompting:
The a small amount of hydrops in thoracic cavity, left side；Conscious left side chest pain Progressive symmetric erythrokeratodermia increases the weight of, diet, sleep poor.TSGF 165U/ml,CA50 178U/
ml,Fer 1092.82ng/ml.2015-09-18 starts to take the ice fire targeting of the oral liquid of above-described embodiment 2 and disappears control tumor medicine
Thing, a 100ML, every twice-daily；After three months, decrement is to once a day, and 2016-03-20 decrement once and was adhered to every three days
Take so far.Normally, left side chest pain disappears, and 2016-03-14 chest X-ray shows in patient diet, sleep at present: thoracic cavity, left side is amassed
Liquid disappears；TSGF 63U/ml,CA50 58U/ml,Fer 291.2ng/ml；2016-04-28 check breast CT prompting: left lung accounts for
Position pathological changes relatively 2014-08 disappears without significant change, the mediastinal lymph nodes of enlargement.
In the present invention, also natural plant kind anti-cancer drug preparation is carried out zoopery, to verify its avirulence.Below
Zoopery, concrete zoopery money has been carried out for sample with the anti-cancer drug preparation of the liquid formulation of the decoction of embodiment 2
Expect as follows:
Weighing of laboratory animal
1, the sensing that mice claims is less than 0.1g.
2, the weight of animals difference of same group of similar sex is less than the 10% of equal body weight.
3, between different groups, the same sex does not moves object weight-average value difference less than 5%.
4, acute toxicity testing, using body weight is the mice of 18-22g, counterpoise 20g.
To weighing, later mice carries out random packet, is grouped as follows shown in table 1.
Table 1 weigh after 50 mice random packet
Table 2 is mice extremely to hurry situation through abdominal cavity dabbling drug.Visible, when dosage reaches 43.2mg/3ml/, mortality rate
P is only 0.9.Nontoxic.
Table 2 mice is through abdominal cavity dabbling drug death condition (LD50 calculates method)
Wherein, i=0.08；Σ P=2.3.
In the present invention, also the state of an illness after the cancer therapy drug of the liquid formulation of the clinical cancer clothes for patients present invention is seen
Examining, statistical result see table shown in 3.
The situation of the cancer therapy drug of table 3 clinical cancer clothes for patients liquid formulation is observed
In table, the cancer therapy drug of the liquid formulation of No. 1 present invention；Supporting Therapy to the ill；
Symptom variation: 0 is unchanged, 1 takes a turn for the better；2 is normal.
The above, the only detailed description of the invention of the present invention, but protection scope of the present invention is not limited thereto, and any
Those familiar with the art, in the technical scope that the invention discloses, can readily occur in change or replace, should contain
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should described be as the criterion with scope of the claims.
Claims (10)
1. a natural plant kind anticancer pharmaceutical composition, it is characterised in that by weight, described anticancer pharmaceutical composition includes
Following raw material: Radix Actinidiae Chinensis 8-15 part, Herba Hedyotidis Diffusae 10-15 part, Folium Eriobotryae 5-10 part, Flos Chrysanthemi Indici 3-10 part, Radix Codonopsis lanceolatae 5-10
Part, dry maxima skin 3-10 part, Rhizoma Arisaematis 3-10 part, charred Nodus Nelumbinis Rhizomatis 5-10 part, Terra Flava Usta 8-15 part, yellow river powder 10-20 part, Stigma Croci 3-
10 parts, Fructus Bruceae 3-8 part and Rhizoma Curcumae 5-10 part.
A kind of natural plant kind anticancer pharmaceutical composition the most according to claim 1, it is characterised in that by weight, institute
State anticancer pharmaceutical composition and include following raw material: Radix Actinidiae Chinensis 10 parts, Herba Hedyotidis Diffusae 12 parts, Folium Eriobotryae 8 parts, Flos Chrysanthemi Indici 6 parts, mountain
Carnis Rapanae thomasianae 8 parts, dry maxima skin 6 parts, Rhizoma Arisaematis 6 parts, charred Nodus Nelumbinis Rhizomatis 8 parts, Terra Flava Usta 10 parts, 16 parts of yellow river powder, Stigma Croci 6 parts, Fructus Bruceae 6
Part and Rhizoma Curcumae 8 parts.
3. natural plant kind anti-cancer drug preparation, it is characterised in that be with resisting according to any one of above-mentioned claims 1 to 3
Cancer drug compositions is that activated feedstock prepares.
Natural plant kind anti-cancer drug preparation the most according to claim 3, it is characterised in that described anti-cancer drug preparation
Dosage form is solid preparation or liquid preparation.
5. the preparation method of natural plant kind anti-cancer drug preparation as claimed in claim 3, it is characterised in that include following step
Rapid:
Step one, according to the anticancer pharmaceutical composition according to any one of the claims 1 to 2 component prepare each raw material,
Each raw mill is become powder；Then according to the consumption of each raw material weighs each material powder, and each material powder is mixed, obtain mixed
Close powder；
Step 2, by the mixed-powder of step one with alicyclic organic embed, obtain pre-treatment substance；Pre-treatment substance is heated above
After the temperature of 300 DEG C, obtain high temperature except the pre-treatment substance after poison；Again high temperature is positioned below subzero except the pre-treatment substance after poison
The low temperature environment of 20 DEG C cools down, pulverizes concentration the most again, obtain the anti-cancer drug preparation of pressed powder agent.
The preparation method of natural plant kind anti-cancer drug preparation the most according to claim 5, it is characterised in that to step 2
The anti-cancer drug preparation of the pressed powder agent prepared adds corresponding solid dosage forms adjuvant, prepares corresponding solid formulation
The anti-cancer drug preparation of type.
The preparation method of natural plant kind anti-cancer drug preparation the most according to claim 5, it is characterised in that also include profit
The anti-cancer drug preparation of the pressed powder agent obtained by step 2 prepares the step 3 of liquid formulation, obtains liquid formulation
Cancer therapy drug.
The preparation method of natural plant kind anti-cancer drug preparation the most according to claim 7, it is characterised in that step 3
Concrete operations are as follows: the anti-cancer drug preparation of pressed powder agent, Myoglobin and the water mix homogeneously that step 2 are obtained must mix
Compound, carries out water proof by mixture and steams, and filters, takes filtrate, obtain liquid formulation；Wherein, the anticarcinogen of pressed powder dosage form
The mass ratio of thing preparation and Myoglobin is 1 5-10.
The preparation method of natural plant kind anti-cancer drug preparation the most according to claim 8, it is characterised in that steam process
For: steam after opening, then insulation steams 10-20min.
10. according to the preparation method of the natural plant kind anti-cancer drug preparation described in claim 7 or 8, it is characterised in that with
The cancer therapy drug of the liquid formulation that step 3 prepares is as active component, after adding respective liquid preparation adjuvant, makes
Anti-cancer drug preparation for corresponding liquid forms.
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| CN103933193A (en) * | 2014-04-29 | 2014-07-23 | 黄葵 | Natural plant type biological anti-cancer medicine |
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