CN105998532A

CN105998532A - Preparation method for traditional Chinese medicine for treating Qi-stagnancy and blood stasis painful heel and composition of traditional Chinese medicine

Info

Publication number: CN105998532A
Application number: CN201610538888.3A
Authority: CN
Inventors: 马佳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-10
Filing date: 2016-07-10
Publication date: 2016-10-12

Abstract

The invention provides a preparation method for a traditional Chinese medicine for treating Qi-stagnancy and blood stasis painful heel. The medicine for oral administration is pills. The preparation method of the traditional Chinese medicine comprises the following steps that firstly, all raw materials are placed into a pulverizer to be pulverized and then screened; secondly, coarse particles obtained after screening are placed into ethyl alcohol to be heated and subjected to reflux extraction for two times, and a component 1 is obtained; in the second step, the coarse particles obtained after screening are placed into the ethyl alcohol to be heated and subjected to reflux extraction for two times, reflux extraction is carried out for 1-2 hours each time, extracting solutions are mixed and stand, liquid supernatant is removed, extracting solutions are mixed, the mixture is subjected to ultrafiltration through an ultrafiltration column with the cutoff molecular weight being 5,000-10,000, ultrafiltrate is subjected to vacuum concentration so that extract with the relative density being 1.36 at the temperature of 80 DEG C can be formed, the extract is heated and concentrated into paste, the paste stands for use, and the component 1 is formed. The medicine acts on a local part, permeates the skin to arrive at the disease position, promotes qi and blood circulation, improves local blood running, softens spurs, promotes inflammation absorption and then relieves or eliminates symptoms.

Description

The Chinese medicinal preparation method for the treatment of qi stagnation and blood stasis type talalgia and combinations thereof thing

Technical field

The present invention relates to, containing the pharmaceutical product deriving from plant, animal or mineral component, treat particularly to one Chinese medicine composition of qi stagnation and blood stasis type talalgia and preparation method thereof.

Background technology

Heel pain is more common in middle-aged and elderly people, and the lighter's only heel pain when walking, severe one is suffered from foot and landed i.e. bitterly, it is impossible to OK Walking or stand, foot also pain suffered from by pendency, very painful.Treating this disease, seldom effective with rheumatism analgesic, closed treating is treated long term Heterodyne.Heel one or both sides pain, the reddest pneumonedema, walking disorder.Also known as relieving heel pain.It is the sclerotin due to heel, joint, cunning The disease that capsule, fascia etc. pathological changes causes.Common for plantar fasciitis, it is frequently experienced in standing for a long time or walking worker, long-term, slow Property slight wound cause, show as sole of the foot fascia fibrous fracture and repair process, below calcaneus, partially the fascia of inner side is depended on locate hyperostosis Life and tenderness, position, side X-ray sheet display calcanean spur.But having bony spur not necessarily to have talalgia, plantar fasciitis not necessarily has bone Thorn.Chinese medicine is thought, talalgia many genus hepatic and renal YIN deficiency, phlegm-damp, heat in blood etc. are because of caused.Liver governing tendons, kidney governing bones, caused by liver and kidney deficiency, muscle Bone loses supports, and sense wind-cold damp pathogen or chronic strain just cause meridian stasis stagnant again, and QI-blood circulation is obstructed, and makes muscles and bones muscle lose and supports and send out Sick.

Qi stagnation and blood stasis type talalgia show themselves in that a variety of causes cause local blood slowly, stagnation of blood stasis, venation is hindered, then QI-blood circulation is smooth and pain, and localized pain, pain with tenderness, walks limited.

The modal reason of talalgia is that long-term, chronic, microtrauma accumulates the pathological changes caused, and shows as fascia fiber Fracture and repair process thereof.Below calcaneus partially in fascia vicinity can have a hyperosteogeny, form bone ridge.At position, side roentgenogram Bony spur it is shown as on sheet.The latter is considered as often the reason of talalgia, but clinical research proves the cause effect relation of it and talalgia Being difficult to certainly, plantar fasciitis differs and establishes a capital with bony spur, has the people of calcanean spur also to differ and established a capital talalgia.Plantar fasciitis draws The talalgia risen can be cured naturally.Padded heel, alleviates the heel string pulling force to calcaneus, front plantar flexion of foot, alleviates opening of sole of the foot fascia Power, all can make symptom alleviate.Injection of drug can be carried out by local pressure pain point inside foot root, once in a week, most after injection Patient can cure in two weeks.

With pad pain often occurs old people, it is to be interval by fibrous tissue below calcaneus with pad, with fatty tissue and elastic force Fibroplastic elastic insert；Nonage, with pad resilient beam, can absorb vibration.Time old, with pad elastic force declines, calcaneus In the case of linerless, undertake body weight, cicatrix and calcium deposition can be formed time serious, cause talalgia.With pad pain and sole of the foot fascia Scorching different, below whole heel, there is tenderness.Therapeutic Method is for using sponge with pad or topical remedy's injection.

After calcaneus the most easily there is the synovial bursa between heel string and skin in bursitis, by inappropriate high heel leather shoes frictionally damage Cause.The variable plumpness of synovial bursa wall, is full of synovial fluid, local swelling, and has tenderness in capsule.Therapeutic Method preferably improves footwear type.If synovial bursa Swelling does not disappears, and can puncture attraction, and can inject hydrocortisone.

Calcaneal apophysitis often betides the boy of 8～12 years old, and pathological changes is similar to calf shank tuberosity apophysitis, is to grow During, the symptom that the epiphysis not healed is caused by tendon tractive, pain, below heel string attachment point, can be fallen ill by bilateral simultaneously. Run and standing on tiptoe can make exacerbation of symptoms.Symptom Lock-out after osteophiphysis.Typically make anti symptom treatment, infant can be made to alleviate Movable, it is also possible to pad alleviates the heel string pulling force to calcaneus.

Astragalus hypozygal is scorching often to be occurred after fracture of calcaneus, is a kind of traumatic arthritis.X-ray photographs is gone forward instep hole Place, during heavy burden, pain increases the weight of.If expectant treatment lost efficacy, then should carry out talocalcaneal joint fusion.

Old fracture of calcaneus or rare calcaneus tumor or tuberculosis are also the reasons of talalgia.Illness beyond heel is drawn Play calcaneodynia person, have rheumatoid spondylitis, the prolapse of lumbar intervertebral disc of compressing sacral nerve roots, occur the tibial nerve at shank to extrude Deng.

The most how to distinguish is the talalgia that causes of which kind of reason？In general, except by means of the most auxiliary Help inspection as outside X-ray, mainly by the sufficient section doctor of specialty, have a medical check-up through clinic, substantially can clarify a diagnosis.Can also apply Therapeutic means are distinguished, the talalgia that such as old people causes due to vola fat pad atrophy, when application local block therapy Time, it is of no curative effect.

Talalgia often shows as first and second step landed pain of getting up morning, just can gradually alleviate after walking a few step.Heel Pain is divided into two kinds: one is true property talalgia, and X-ray confirms to truly have the formation of calcanean spur, pain spot to concentrate；Another kind is false Talalgia, X-ray does not has the formation of bony spur hypertrophy, heel portion constant pain, and both legs have heavy weak sense.Two kinds of talalgia are mutual Any association is not had between Xiang.

From the angle analysis of the traditional Chinese medical science, talalgia belongs to the one of rheumatism involving the bone, how because of the hepatic and renal YIN deficiency, caused by cold-evil.Talalgia is A kind of disease that old people is common, but the sickness rate in young woman rises year by year now, particularly as white collar clan, on The cooling slippers of fashion style is worn by class, and heel minister's phase exposes, and easily by attacked by the cold and evil in air-conditioned room, is After Hours busy with strolling Street, jumping slimnastics, foot fails again well to be had a rest, and due to the long-term pressurized of heel, hyperkinesia with have a cold, causes foot With fat fiber mat aseptic inflammation, finally induce pain.

False talalgia is preventable, notes the warming of heel portion at ordinary times, it is to avoid excessively walk or stand, can before sleeping Using warm water foot bath, or foot is given hot compress, soft sole is worn in selection the most as far as possible, as sarapus, more it is noted that avoided Degree motion, preferably can also put on corrective shoes.

Puerpera in puerperal period, QI and blood deficiency, it is easy to cold gas of suffering from cold.Particularly foot, including heel, is once subject to Cool, arise that pain in the date afterwards.Puerperal, talalgia was deficient syndrome, was not wound, was also not belonging to caused by bony spur.This Puerperal disease, to suffer from a deficiency of the kidney, puerperal wears high heels, and wears slippers, sandals the most barefoot, may often be such that important inducement.

Kidney is unit's the dominator of QI, kidney governing reproduction, main bone.According to meridians circulation route, heel belongs to the scope of kidney channel circulation.Heel Pain is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia is also known as calcanean spur Or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains with old deficiency of the kidney, wound and experience cold-damp Relevant.With the passing of time or from the beginning of talalgia, select the herbal medicine immersion of numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, invigorating blood circulation analgesia Or external application foot, not injured skin, without toxicity.

Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ", Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.The Qing Dynasty's famous physician Xu Ling tire is said: " modern used Plaster, the plaster applying a plaster for therapeutic purpose of ancients' meaning..... control inner person, or wind dispelling trembled with fear, or and QI and blood, or expectorant painful abdominal mass, or strengthening bone and muscle, its side is very clever, Medicine is also added and subtracted with disease, and its cream preferably weighs thick patch for a long time.”

Western medicine therapy

Operative treatment: 1. spur in heels excision, for intractable macLean-Maxwell disease, X sheet confirms there is bony spur person, inside calcaneus Make a kerf, enter calcaneus, operative treatment talalgia bony spur inside calcaneus is all filed and removes.

2. calcaneus Drilling: high person intrinsic pressure to calcaneus is suitable for, it is therefore an objective to make the intrinsic pressure reduction of calcaneus increased, treats intractable Without the calcaneodynia of bony spur, still at calcaneus inner incision, after reaching calcaneus, by calcaneus drilling on inner side 7～10, effect reaches 90%.

3. calcaneus neurotomy: for this method can be used without reason intractable talalgia, but be a kind of destructive hands Art, props up calcaneus posterior tibial nerve and props up cut-out with sural nerve.

4. calcaneus Synovectomy: be that synovial bursa under calcaneal tuberosity synovial bursa and calcaneus is excised.

5. the osteotomy of calcaneus art of flat foot: purpose is to make calcaneus angle increase by osteotomy of calcaneus, and the calcaneus turned up is ajusted, and makes Calcaneus has a good biological support.

Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but plants destructive operation, by calcaneus posterior tibial nerve Prop up and sural nerve props up cut-out, have side effect in various degree or cause some complication；Chinese medicine product is then because of its sky of drawing materials So, safety side effect good, low, documents and materials are abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor, Can not fundamentally alleviate the symptom of talalgia, and the most certain side effect.Therefore, the Chinese medicine of a kind of highly effective and safe is found Compositions becomes the urgent needs of people.

Summary of the invention

The technical problem to be solved is, talalgia is a kind of commonly encountered diseases, with heel swelling, numb pain, Locally tenderness, difficulty in walking are characterized.Talalgia is also known as calcanean spur or heel bone hyperosteogeny." rheumatism involving the bone " model is belonged in Chinese medicine Farmland, pathogenic factor is many strains with old deficiency of the kidney, and wound is with to experience cold-damp relevant.Qi stagnation and blood stasis type talalgia shows themselves in that various former Because of cause local blood slowly, stagnation of blood stasis, venation is hindered, then QI-blood circulation is smooth and pain, and localized pain, pain with tenderness, Walk limited.

For solving these technical barriers, the invention provides a kind of Chinese medicine composition treating qi stagnation and blood stasis type talalgia, Its described Chinese medicine composition is made up of with external used medicine endo-medicine, and endo-medicine can include the raw material of following parts by weight Medicine: the Radix Astragali 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Fructus Psoraleae 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Ecliptae 10～20 parts, Rhizoma Cyperi 10～20 parts, Radix Bupleuri 10～20 parts, Rhizoma Drynariae 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10 ～20 parts.

Described Chinese medicine composition external used medicine can include the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Fructus Foeniculi 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Herba Lycopodii 10～20 Part, Fructus Liquidambaris 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Pheretima 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts, Flos Carthami 10～20 parts, Caulis Piperis Kadsurae 10～20 parts.

The Chinese medicine composition of described treatment qi stagnation and blood stasis type talalgia, its endo-medicine can also include following parts by weight Crude drug: the Radix Astragali 10～15 parts, Rhizoma Dioscoreae 10～15 parts, Fructus Psoraleae 10～15 parts, Radix Rehmanniae Preparata 10～15 parts, Radix Angelicae Pubescentis 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Achyranthis Bidentatae 10～15 parts, Flos Carthami 10～15 parts, Fructus Lycii 10～15 parts, Radix Angelicae Sinensis 10～15 parts, Herba Ecliptae 10～ 20 parts, Rhizoma Cyperi 10～20 parts, Radix Bupleuri 10～20 parts, Rhizoma Drynariae 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, chicken Caulis seu Radix Schisandrae Henryi 10～20 parts.

Described Chinese medicine composition external used medicine can also include the crude drug of following parts by weight: Radix Dipsaci 10～15 parts, in vain The root of Dahurian angelica 10～15 parts, Fructus Foeniculi 10～15 parts, Rhizoma Chuanxiong 10～15 parts, Herba speranskiae tuberculatae 10～15 parts, Radix Notoginseng 10～15 parts, Herba Lycopodii 10～ 15 parts, Fructus Liquidambaris 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Pheretima 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts, red Spend 10～20 parts, Caulis Piperis Kadsurae 10～20 parts.

The Chinese medicine composition of described treatment qi stagnation and blood stasis type talalgia, its endo-medicine can also include following parts by weight Crude drug: the Radix Astragali 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Fructus Psoraleae 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Ecliptae 10～ 15 parts, Rhizoma Cyperi 10～15 parts, Radix Bupleuri 10～15 parts, Rhizoma Drynariae 10～15 parts, the Cortex Eucommiae 10～15 parts, Rhizoma Corydalis 10～15 parts, chicken Caulis seu Radix Schisandrae Henryi 10～15 parts.

Described Chinese medicine composition external used medicine can also include the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, in vain The root of Dahurian angelica 10～20 parts, Fructus Foeniculi 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Herba Lycopodii 10～ 20 parts, Fructus Liquidambaris 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Pheretima 10～15 parts, Radix Clematidis 10～15 parts, Radix Saposhnikoviae 10～15 parts, red Spend 10～15 parts, Caulis Piperis Kadsurae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for a kind of system treating qi stagnation and blood stasis type talalgia Chinese medicine composition Preparation Method, its described endo-medicine is that the preparation method of pill comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving；

B. after sieving, remaining coarse granule puts into heating and refluxing extraction 2 times in ethanol, becomes component 1；

Take the medicinal residues after above-mentioned ethanol extraction the most again to add water, heating and refluxing extraction 2 times, become component 2；

D. by 2-in-1 to component 1 and component also, decompression recycling ethanol is also spray-dried, and obtains medicated powder；Mix the fine powder obtained that sieves It is twisted into pill with Mel.

In described step a, described crude drug can be put into after pulverizer is pulverized and cross 120 mesh dusting covers, enable by 120 mesh The fine powder amount of sieve is reaching 20%, collects standby by the raw material fine powder of 120 mesh sieves.

In described step b, after can sieving, remaining coarseparticulate puts into heating and refluxing extraction 2 times in ethanol, every time 1～2 hour, 2 extracting solution are merged and stand, remove supernatant, united extraction liquid, then through the molecular weight that dams be 5000-10000's Ultrafiltration post ultrafiltration, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heat and be concentrated into paste, stand for standby use, Become component 1.

In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 10 times amount water heating and refluxing extraction 2 times, each 1 ～2 hours, 2 extracting solution are merged and stand, remove supernatant, united extraction liquid, then through the molecular weight that dams be 5000-10000's Ultrafiltration post ultrafiltration, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heat and be concentrated into paste, stand for standby use, Become component 2.

In described step d, economic benefits and social benefits can be inserted after decompression recycling ethanol be concentrated in vacuo 2-in-1 also to said components 1 and component In device, when being concentrated into 90 DEG C, relative density is the extractum of 1.36, is concentrated into every 1ml crude drug amount Han 0.1g, then passes to spray dried Dry machine is spray-dried, and the compressed air pressure crossing spray dryer shower nozzle is 5kg/m², hothouse hot stream temperature is 100 DEG C, obtain raw material medicated powder；The raw material fine powder obtained after sieving mixes with raw material medicated powder, adds Mel and is twisted into pill.

For solving above-mentioned technical problem, the present invention reoffers a kind of system treating qi stagnation and blood stasis type talalgia Chinese medicine composition Preparation Method, its described external drug dosage forms is unguentum, and its preparation process is: the raw medicinal material of above-mentioned ratio of weight and number is added 5- Soaking 7-10 days in the Oleum Sesami of 10 times of weight portions, heating, big fire boils, and after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations in Dark brown, internal coke yellow, to pull medicinal residues out, continue to temper by medicine oil, and be stirred continuously, refining is to beading of dripping；Plumbum preparatium is fried extremely Vermilion, removes moisture, crosses 100-120 mesh sieve and removes impurity；Plumbum preparatium is slowly added in the medicine oil refined, is stirred continuously, become The thick paste of black, is poured in cold water after the plaster that refined is the coldest, soaks 5-10 days, change water every day once, releasing fire-toxin；Paste making agent.

The Chinese medicine composition of described treatment treatment qi stagnation and blood stasis type talalgia, its described endo-medicine dosage form can be: sugar Garment piece agent, film coated tablet, hard capsule, soft capsule, oral liquid, granule, electuary, honey pill agent, powder, sublimed preparation, solution Agent, injection, plaster, powder or slow releasing capsule；Described external drug dosage forms can be: spray, ointment, tincture, cream Agent, patch, herbal fumigation agent or Local out dressing gauze agent.

Talalgia is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia Also known as calcanean spur or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains, outward with old deficiency of the kidney Hinder with to experience cold-damp relevant.Qi stagnation and blood stasis type talalgia show themselves in that a variety of causes cause local blood slowly, stagnation of blood stasis, arteries and veins Network is hindered, then QI-blood circulation is freely and not bitterly, and localized pain, pain with tenderness, walks limited.Doctor trained in Western medicine typically solves this with operation and asks Topic, though there being certain curative effect, but planting destructive operation, being propped up by calcaneus posterior tibial nerve and propping up cut-out with sural nerve, having in various degree Side effect or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials Enrich, clinical efficacy is good and enjoys favor.Oral administration and externally amalgamation of the present invention, can effectively expand peripheral vessel, improve foot Microcirculation, blood stasis dispelling of subsiding a swelling, activating collaterals to relieve pain effect is obvious.Medicine acts on local, permeates skin, through sick institute, promotes QI and blood stream Logical, improve local blood and run, soften bony spur, promote that inflammation absorbs, so that remission or elimination.Therapeutic effect of the present invention More satisfactory, and non-toxic and safe, preparation method is simple and easy to do, can create good social benefit and economic benefit.

Detailed description of the invention

Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ", Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.

Plaster is a wonderful work of motherland's medical science, Gu have " reason of the external treatment i.e. reason for the treatment of by oral administration of medicines, the medicine of the external treatment i.e. medicine for the treatment of by oral administration of medicines, Different person, method ear ", " it is sick that plaster can control treatment by Chinese herbs macLean-Maxwell disease, and not different from decoction is done in the proper way with it, its ring vertical should " etc. saying.The Qing Dynasty Famous physician's Xu Ling tire is said: " modern plaster used, the plaster applying a plaster for therapeutic purpose of ancients' meaning..... control inner person, or wind dispelling trembled with fear, or and QI and blood, or Expectorant painful abdominal mass, or strengthening bone and muscle, its side very spirit, medicine is also with disease plus-minus, and its cream preferably weighs thick patch for a long time.”

One, qi stagnation and blood stasis type: a variety of causes cause local blood slowly, stagnation of blood stasis, venation is hindered, then QI-blood circulation is not Freely pain, and localized pain, pain with tenderness, walk limited.

Two, deficiency of the liver and kidney: the other network of Liver and kidney and branch thereof is walked around heel, liver governing tendons, main store blood, and kidney governing bones, main Tibetan The raw marrow of essence, essence.Old body, deficiency of the liver and kindey, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, therefore When standing or walk heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.

Three, cold blood stasis type: QI-blood circulation is slow, feels cold-evil again, cold main stagnates, main spasm, causes meridians to be hindered, QI and blood Stagnate obstructed and pain, pain with tenderness, happiness heat be afraid of cool.

Can make anesthesia needle, effect is fast, and relative costs is cheap.First inject a pin at pain point, see that pain condition can be partly A pin is strengthened after individual month.But anesthesia needle is it cannot be guaranteed that thoroughly solve.Young woman is cautious use of, and is amcinonide, can cause 2-3 Cycle menoxenia, had better not be conceived in half a year." anesthesia needle is by the position of drug injection to pain, reaches antiinflammatory, pain relieving Purpose, and have alleviate local muscular tone effect.Time length can be more than the pipe several years, short several weeks, depending on state of an illness weight, time Between length indefinite.This is a kind of symptomatic treatment measure, and the pain symptom eliminating local is had preferable effect.

Tcm syndrome differentiation and treatment, classification therapy: 1. kidney yin deficiency type: foot shin intermittent fever and talalgia, add Carapax et Plastrum Testudinis, meat with pill of Six Ingredients Osmanthus.2. kidney yang deficiency syndrome: can not standing for a long time and talalgia, with eight taste balls.3. wetness type: weigh and swell, with changing bone pellet, history state public affairs medicine Wine.4. multiple abscess caused by damp-phlegm type: add Fructus Chaenomelis, Bi, Radix Stephaniae Tetrandrae with Daotan Tang.5. QIXUELIANGXU type: with BUZHONG YIQI TANG, medicinal piece of shiquan dabu Soup.6. blood-heat type: add the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae (see " Elementary Medicine tinea pedis ") by SIWU TANG.

Fumigation and wash method decocted by all liquid medicine, and medicine acts on local, permeates skin, through sick institute, promotes qi and blood circulation, improve local blood Liquid runs, and softens bony spur, promotes that inflammation absorbs, so that remission or elimination.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, Unsting and invigorate blood circulation.

Radix Angelicae Pubescentis, Chinese medicine name.For samphire Angelica pubescens Angelica pubescens The dry root of Maxim.f.biserrata Shanet Yuan.Acrid in the mouth, hardship, slightly warm in nature.Return kidney, bladder warp.Effect is dispeled the wind and is removed Wet, arthralgia aggravated by cold pain relieving.Curing mainly for anemofrigid-damp arthralgia, pain to be washed, few the moon volt wind headache, wind and cold holds wet headache under the arm." book on Chinese herbal medicine converges and says ": Radix Angelicae Pubescentis, benefaction blood system, the medicine of the wet cold expelling of row that dispels the wind is also.The card of all sick wind, as head term can not pitching, waist knee joint can not bend and stretch, or numbness Pain is difficult to walk, numbness need not, all wind is caused with cold, and summer-heat is with wet institute wound also；Must be warm by the toil of Radix Angelicae Pubescentis, activity QI and blood, dispel Cold expelling is evil, therefore " herbal " speech can dissipate tinea pedis, changes renal mass, treats hernia abdominal mass, subduing inflammation, controls harmful wind hundred joint and attacks bitterly, the strongly fragrant headache of YIN-cold less, It is intended to this.

Rhizoma Dioscoreae also known as Rhizoma Dioscoreae, soil potato, mountain Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae, is " China book on Chinese herbal medicine " medical herbs of recording, medicine It is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome with source.It is strong that Rhizoma Dioscoreae has nourishing, aid digestion, holds back sweating due to debility, and effect of antidiarrheal cures mainly Insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequency, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.Rhizoma Dioscoreae Optimum is taken with Ganoderma collocation, has the effect preventing and treating diabetes, and Rhizoma Dioscoreae is the most rising on grocery trade and processing industry.

Fructus Psoraleae acrid in the mouth；Bitter in the mouth；Warm in nature return through kidney；Pericardium；Spleen；Stomach；Lung meridian function cures mainly: reinforcing the kidney and supporting YANG；Improving inspiration by invigorating kidney-QI is put down Breathe heavily；Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG；Below element deficiency and cold；Chills and pain of the waist and kness；Sexual impotence essence；Frequent micturition；The enuresis；Failure of the kidney in receiving QI；Dyspnea due to deficiency is more than； Asthenia of both the spleen and kidney；Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, can warming the kidney；Raw sun in the moon, the key medicine of excessive fire benefit soil is also.They are main five years old Labor seven kinds of impairments, the disease of lid edge impairment caused by overstrain, arise from asthenia of both the spleen and kidney more, with its can warming the kidney, mend fire with the raw-soil, then in kidney kidney-Yang be so incensed that mend And rise, then can digesting food, steam waste matter and change precise and tiny.Be attributed to lung on spleen-QI transporting the essence to the whole body, with honor support the five internal organs, therefore main the five internal organs it Labor.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, the most air-cooled taking advantage of a weak point in opponent's defence and visitor, so that bone marrow wound loses, the cold essence of kidney flows, Kidney governing bones and store essential substances, marrow be essence this, the gas of kidney-Yang is solid, i.e. before card see, solid and its yang-energy is raw, then front card removes in vain.Man Son is based on essence, and married woman is based on blood, and married woman vim and vigour person, the most still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, with man Kidney cold essence stream also.

Radix Angelicae Sinensis: its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, has benefit, really in row Gas medicine in blood, the also panacea in blood.About then the mending to mend of assistant, therefore can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, Benefit mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, thus can dispel pain relieving constipation, relieving rigidity of muscles and joints, control contracture, paralysis, The card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant, with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can dissipate greatly Biao Weire, and person do not held back by table, help with Radix Et Rhizoma Rhei Etc, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore it is intended to its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidates person when keeping away it.In all the moon Fire Sheng person, the active blood of Radix Angelicae Sinensis, the most non-preferably, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable

The Radix Astragali is the pure natural product that the common people often eat, and folklore blurting out of " often drinking astragali seu Hedysari Decoction, disease-prevention health health " Slip, mean and decoct soup or soaked generation tea-drinking through the conventional Radix Astragali, there is good disease-prevention health effect.The Radix Astragali and Radix Ginseng all belong to benefit Gas good medicine, Radix Ginseng biases toward strongly invigorating primordial QI, recuperating depleted YANG and rescuing the patient from collapse, is usually used in the emergency cases such as collapse, shock, and effect is preferable.The Radix Astragali then with Qi-restoratives is main, be usually used in asthenia with the passing of time, speech is low, thready pulse without strength person.Some people one meets Changes in weather and is easy for flu, the traditional Chinese medical science Being referred to as " table is not solid ", can carry out consolidating superficial resistance with the Radix Astragali, the informal dress Radix Astragali can avoid regular flu.Modern medicine study shows, yellow Stilbene have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action.Can eliminate real The property tested nephritic proteinuria, strengthens myocardial contraction, regulates blood sugar content.The Radix Astragali can not only coronary artery dilator, improve cardiac muscle supply Blood, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter Dish etc..

The Cortex Eucommiae, the medicinal Cortex Eucommiae, it is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Its sweet in the mouth, Warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, consolidate through antiabortive effect.Lumbago and skelalgia or acid that insufficiency of kidney-YANG causes can be treated Soft unable, the diseases such as born of the same parents' tire that deficiency of liver-QI causes is not solid, scrotum pruritus due to damp pathogen.Shennong's Herbal is listed in top grade.The Cortex Eucommiae is dissociated Aminoacid is few, a small amount of protein contained, be with most foodstuffs as adequate proteins, i.e. can hydrolyze detection to people 8 kinds of aminoacid that body is required.Determine 15 kinds of mineral elements contained by the Cortex Eucommiae, wherein have trace element such as zinc, copper, ferrum, and calcium, The macroelements such as phosphorus, potassium, magnesium.The modern study Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle Skeleton is aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat clearing away, wide spectrum Antibacterial, stimulating central nervous system, improves leukocyte pharmacological action.

Rhizoma Corydalis, (Corydalis yanhusuo W.T.Wang ex Z.Y.Suet C.Y.Wu), have another name called: Rhizoma Corydalis, profound Rhizoma Corydalis, rhizoma corydalis, Rhizoma Corydalis etc..Being Papaveraceae, Corydalis herbaceos perennial, tuber is spherical, petal aubergine；Capsule cylinder Shape, two ends are the narrowest.Summer-flowering.Tuber is famous conventional Chinese medicine, containing more than 20 kinds of alkaloids, for promoting the circulation of QI to relieve pain, Huoxue San " The stasis of blood, traumatic injury etc..Cure mainly: invigorate blood circulation；Dissipating blood stasis；Regulate the flow of vital energy；Pain relieving.Main trusted subordinate's all pains of waist knee joint；Menoxenia；Lump in the abdomen；Metrorrhagia；Puerperal Bruise；Lochiorrhea；Traumatic injury." medicine origin ": control that taste are depressed stagnant not to be dissipated, main asthenia cold diarrhea, cardiac and abdominal pain, the therapeutic method to keep the adverse QI flowing downwards disappears Food." detailed outline ": invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis.Rhizoma Corydalis, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control the most all Bitterly, among use, simply fantastic.

Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called Radix Rehmanniae Preparata or volt Ground, the processed process of preparing Chinese medicine forms.Generally with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant through repeatedly steaming solarization, glossy to inside and outside darkish complexion, quality is soft Sticky.Section use, or parch to black use.Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and belongs to goatweed, is a kind of first-class Chinese crude drug, has YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menoxenia, the disease such as metrorrhagia, also can be used for deficiency of kidney yin Hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, the disease such as quench one's thirst, be one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.

Rhizoma Drynariae is bitter, temperature.Enter liver, kidney channel.Function cures mainly the kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatism numbness Bitterly, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " poison in main bone, wind blood pain, five Labor six types of severe debility disease, mouth (one make ' foot ') hands do not receives, upper heat and lower cold." " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing.″

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." day China's son book on Chinese herbal medicine ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, row Pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.

Pheretima: Compendium of Material Medica referred to as has dredge the meridian passage, blood circulation promoting and blood stasis dispelling, prophylactic treatment cardiovascular and cerebrovascular disease effect. Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly high fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, half Body is unsuccessful.

Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami belong to Plant, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, and flower pesticide yellow is unified into pipe, exceeds Outside sliver, its central authorities have stigma to expose.Have special fragrance, mildly bitter flavor.To spend, length of a film, color be scarlet, the soft person of matter is preferred.Invigorate blood circulation Stimulate the menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, breast side of body twinge, traumatic injury, Skin infection swells and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.

Radix Notoginseng is to be used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has " gold Do not change ", the good reputation of " southern part of the country SHENCAO ".Because season in Chang Chun winter two excavates, it is divided into again " spring seven " and " winter seven ".Qing Dynasty's pharmaceutical texts Described in supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for Most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", i.e. with Radix Notoginseng for primary raw material system Become.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, head The most lossless, cold-damp numbness, upper limb rheumatalgia.Dissipate exterior cold；Wind-damp dispelling；Profit joint；Pain relieving.Main affection of exogenous wind-cold；Have a headache lossless；Edema due to wind pathogen Edema；Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, Alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and dampness, pain relieving.Property of medicine opinion ": " controlling harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, actinal surface is askew more Heresy, insensitive impediment all over." " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are won bad, the head rotation red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times Aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.″

Rhizoma Chuanxiong, formal name used at school: Ligusticum chuanxiong hort, cultivated plant, main product is in Sichuan (Guanxian county), at cloud The ground such as south, Guizhou, Guangxi, are grown on the climatic environment of gentleness.It is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keeps, can go scattered, up up to top, mountain peak；Enter again blood system, descending up to the sea of blood.Blood circulation promoting and blood stasis dispelling is made With extensively, the various disease of suitable stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.Former times people Meaning Rhizoma Chuanxiong is the gas medicine in blood, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving.

Radix Achyranthis Bidentatae medical value root is used as medicine, raw use, promoting blood circulation to restore menstrual flow；Control puerperal abdonimal pain, menoxenia, amenorrhea, epistaxis, asthenic fire tooth Bitterly, tinea pedis edema；Ripe use, invigorating the liver and kidney, strong waist knee joint；Control soreness of waist and knee joint, caused by liver and kidney deficiency, traumatic injury stasis of blood pain.Veterinary is used as to control cattle weak foot Disease, gets injured by a fall knochenbruch etc..Medicinal part: the dry root of plant.Nature and flavor: bitter, sweet, sour are flat.Gui Jing: return liver, kidney channel.Effect: removing blood stasis Stimulate the menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.Cure mainly: for amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, drench Card, edema, headache, dizziness, toothache, day skin ulcer, spit blood, epistaxis.

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, after mixing steaming with Semen sojae atricolor liquor Dry and be used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treating scrofula Scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Radix Polygoni Multiflori Preparata function invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, Vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.Radix Polygoni Multiflori Preparata of the present invention It it is the good merchantable brand of invigrating kidney.

Fructus Lycii: sweet, flat.Folium Lycii: bitter, sweet；Cool in nature.Function: Fructus Lycii: nourishing the liver, nourishing kidney, lung moistening.Folium Lycii: qi-restoratives Benefit essence, clearing away heat to improve acuity of vision.Lycium barbarum polysaccharide is a kind of water soluble polysaccharide, is topmost active component, relative molecular mass in Fructus Lycii For 68-200, become domestic and international study hotspot.The most again with immunomodulating and the most study of antitumor action of lycium barbarum polysaccharide. There is now a lot of research and show that lycium barbarum polysaccharide has promotion immunity, defying age, antitumor, removing free radical, resisting fatigue, anti-spoke Penetrate, protect the liver, the effect such as reproductive function protection and improvement.

Herba Ecliptae grass is the conventional liver-nourishing kidney-boosting of the traditional Chinese medical science, cooling blood for hemostasis medicine.To the Light-headedness caused by the hepatic and renal YIN deficiency, tooth Loose compact, aching pain in waist and back, all diseases of flaccidity and weakness of the lower limbs and caused by heat in blood multiple go out blood disorder have good efficacy.Herba Ecliptae contains volatilization The chemical compositions such as oil, tannin, Saponin, Herba Ecliptae element and vitamin A.Animal experiment has haemostatic effect, and in vitro tests is to golden yellow Staphylococcus has inhibitory action.

Caulis Spatholobi, for the another name of the various plants such as Schisandraceae, Sargentodoxaceae, Cuscutaceae, Papilionaceae.8～JIUYUE adopt Receive, be distributed in China East China, South China and the ground such as Hubei, Yunnan.Caulis Spatholobi bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel, color Red enter blood, matter profit row dissipate；There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation；Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, the moon Through uncomfortable, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.Treat the waist gonalgia caused by rheumatism, rheumatic arthralgia, limb Body is numb, often and the compatibility such as Flos Carthami Radix Angelicae Pubescentis, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, dysmenorrhea, Often use together with Rhizoma Cyperi, Herba Leonuri.

Radix Dipsaci, has another name called Radix Dipsaci, also name Radix Dipsaci, Chinese medicine name.For the root of herbaceos perennial Radix Dipsaci, because of energy, " continuous folding connects Bone " and gain the name.Autumn excavates, and removes root head and fibrous root, is dried to low baking temperature half-dried, when bank up " diaphoresis " is to internal virescence, then Dry." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians are determined in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, antiabortive, is suitable for controlling married woman leucorrhea, Tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Herba speranskiae tuberculatae, (formal name used at school: Phryma leptostachya L.subsp.asiatica (Hara) Kitamura) is used as medicine Part is plant herb.Green, dry with herb color, matter is tender, free from admixture person is preferred.It is distributed in all parts of the country.It mostly is artificial plantation. Reddish brown with stem color, without leaf, be dried, free from admixture person is preferred.Annual herb flowers, produce the nations of China and India.Property happiness sunlight, be afraid of Wet, heat-resisting can not resist cold, suitable be born in loose fertile micro-sour soil earth, but the most barren-resistant.Adaptability is relatively strong, transplants and easily survives, growth Rapidly.Seed also name Semen Impatientis, stem also name Herba speranskiae tuberculatae, all can be used as medicine, have blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow. External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.

Radix Clematidis belongs to medicinal plants, and medical material Ji Yuan source is more, " Kaibao Bencao ", " Bencao Tujing ", herbal for Relief of Famines Etc. contained Radix Clematidis, for goatweed；The Radix Clematidis that " the southern regions of the Yunnan Province book on Chinese herbal medicine " is contained, is feverfew, and uses many now For " China's book on Chinese herbal medicine " contained cohosh Radix Clematidis, Clematis hexapetala, northeast clematis.Domestic distributed more widely, its root and stem It is used as medicine and there is wind-damp dispelling, the meridian dredging, the effect of the bone stalk that disappears.In modern clinic is put into practice, its new purposes is constantly found, as Treatment cholelithiasis, calcanean spur, talalgia, the esophageal carcinoma etc..Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, dissipate the hypochondriac lump.Cure mainly gout Insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, muscle arteries and veins contracture, joint stuffiness, tinea pedis, malaria, lump in the abdomen, tetanus, flat Fructus Persicae body is scorching, and all a fishbone or other bone caught in the throat swallow.Tang Materia Medica: waist, kidney, foot knee joint, accumulation, all cold diseases of enteral, is not recovered, the effect of clothes." Kai Baoben Grass ": main all wind, logical five Tibetan of a surname, cold stagnant in removing abdomen, septum cordis expectorant water amasss for a long time, and lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, waist knee joint is cold Pain and treatment injured.

Radix Saposhnikoviae, Chinese medicine name.Another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds.It is the name of a kind of medicinal herbs, perennial herb Plant, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae With.Acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.

Rhizoma Cyperi hardship pungent, micro-, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Effect dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.Main Controlling for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, and menstruation is not Adjust, amenorrhea dysmenorrhea." detailed outline ": the gas of Rhizoma Cyperi is flat and does not trembles with fear, fragrant and can alter, the how pungent energy of its taste dissipates, and micro-hardship can drop, micro-sweet energy with.

Radix Bupleuri, Chinese medicine name.The medical herbs included for " Chinese Pharmacopoeia ", medicinal part is umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii. Dry root.Spring, season in autumn two excavate, and remove stem and leaf and silt, are dried.Radix Bupleuri is conventional diaphoretic medicine.Another name smoke, mountain dish, mushroom Grass, faggot, nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian.There are reconciling superficies and interior, effect of soothing the liver yang invigorating.Past for cold, fever, cold and heat Come, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.

Fructus Liquidambaris: Latin entitled FRUCTUS LIQUIDAMBARIS.Hardship, flat.Return liver, kidney channel.Function cures mainly work of dispeling the wind Network, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.A Supplement to the Compendium of Materia Medica ": meridians contracture of relaxing, Arthralgia pain all over the body, trick and lumbago.

Herba Lycopodii is the herb of Lycopodiaceae Lycopodium plant Lycopodium clavatum Lycopodium japonicum Thunb..Control joint Bitterly: Radix et Rhizoma Smilacis Ripariae five money, roadside chaste tree one or two, Radix Ilicis Pernyi one or two, Herba Siegesbeckiae five money.It is decocted in water for oral dose.(" Hunan medicine will ") meridian distribution of property and flavor: Toil temperature, enters Liver Channel.Attending effectiveness: expelling wind and cold. dehumidifying detumescence, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle. External is controlled osteopatia sprain and is swollen and ache.

Caulis Piperis Kadsurae: latin name CAULIS PIPERIS KADSURAE.Caulis Piperis Kadsurae is that dicotyledon medicine Piperaceae plant is thin The rattan of leaf green grass or young crops beach wormwood rattan.Medical material is the rattan of Piperaceae plant pipex kadsura, and meridian distribution of property and flavor is pungent, bitter, tepor.Return Liver Channel. Effect is temperature of dispeling the wind, the meridian dredging.Can treat for anemofrigid-damp arthralgia, articular instability, lumbocrural pain, muscle arteries and veins contracture.Lung cold is breathed with cough, and bends It is unfavorable to stretch." book on Chinese herbal medicine is the newest ": network of passing through, and blood vessels, alleviating distention in middle-JIAO regulates the flow of vital energy, under wet except wind, manage waist tinea pedis, control hernia, antiabortive." Kai Baoben Grass ": main air blood, mend aging, play sun, strong waist foot, eliminating impediment, bleach, by cold air, air draft is evil.Also liquor clothes, also infusing drugs in wine clothes, the eleventh month of the lunar calendar With it." Bencao Tujing ": control lumbago.

Specific embodiment 1

The preparation of oral pills of the present invention:

By Radix Astragali 1000g, Rhizoma Dioscoreae 1000g, Fructus Psoraleae 1000g, Radix Rehmanniae Preparata 1000g, Radix Angelicae Pubescentis 1000g, Radix Polygoni Multiflori Preparata 1000g, cattle Knee joint 1000g, Flos Carthami 1000g, Fructus Lycii 1000g, Radix Angelicae Sinensis 1000g, Herba Ecliptae 1000g, Rhizoma Cyperi 1000g, Radix Bupleuri 1000g, Rhizoma Drynariae 1000g, Cortex Eucommiae 1000g, Rhizoma Corydalis 1000g, Caulis Spatholobi 1000g, add soak with ethanol 2-3 hour accounting for its quality 7-10 times, add Heat extracts 2 times, each 1-2 hour, and united extraction liquid removes supernatant after standing, then 100-120 mesh filters, then through damming point Son amount is the ultrafiltration post ultrafiltration of 5000-10000, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.Again by upper The medicinal residues stating the crude drug that ethanol extraction is crossed add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, extract 2 times Liquid merges standing, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mixes two kinds of extraction filtrates and inserts economic benefits and social benefits In vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；By cold preservation The filter aid kieselguhr that liquid adds 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug Han 0.1g Amount, then adds Mel and is twisted into pill.

Specific embodiment 2

The present invention takes granule orally:

By Radix Astragali 1200g, Rhizoma Dioscoreae 1100g, Fructus Psoraleae 1200g, Radix Rehmanniae Preparata 1100g, Radix Angelicae Pubescentis 1200g, Radix Polygoni Multiflori Preparata 1100g, cattle Knee joint 1100g, Flos Carthami 1200g, Fructus Lycii 1100g, Radix Angelicae Sinensis 1200g, Herba Ecliptae 1100g, Rhizoma Cyperi 1100g, Radix Bupleuri 1200g, Rhizoma Drynariae 1100g, Cortex Eucommiae 1100g, Rhizoma Corydalis 1200g, Caulis Spatholobi 1100g, chopping is soaked to be placed in lid stainless steel cask, adds 70% Ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By percolation Bottom Tong filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then with rustless steel spoon contain Powder, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitable Working as pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens under percolator The baiting valve in face, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have second Alcohol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation Speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and pours ethanol during emptying into storage Fluid cylinder；Percolate is merged and stands, stand for standby use；The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C Relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, Filtering, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, adds dextrin or granulated into particles.

Specific embodiment 3

The preparation method of external spraying agent:

Radix Notoginseng 1000g, Radix Angelicae Dahuricae 1000g, Fructus Foeniculi 1000g, the Rhizoma Et Radix Notopterygii 1000g way of distillation are vaporized into crystallization, and pulverizing is treated With, for component 1；Other raw materials Radix Dipsaci 1000g, Rhizoma Chuanxiong 1000g, Herba speranskiae tuberculatae 1000g, Herba Lycopodii 1000g, Fructus Liquidambaris 1000g, Qiang Live 1000g, Pheretima 1000g, Radix Clematidis 1000g, Radix Saposhnikoviae 1000g, Flos Carthami 1100g, Caulis Piperis Kadsurae 1200g soak with ethanol, heating Boiling 3 times, each 1-2 hour, filter, filtrate is standby；To merge in the filtrate suction concentrating under reduced pressure tank of latter 3 times, concentrating under reduced pressure It is 1.20 to relative density, the extractum of temperature to 60 DEG C-70 DEG C；Become component 2, blending ingredients 1 and component 2, mediation substrate, dress Enter in aerosol apparatus.

Specific embodiment 4

Preparation method by externally used paste of the present invention:

According to described number by raw material Radix Dipsaci 1200g, Rhizoma Chuanxiong 1100g, Herba speranskiae tuberculatae 1200g, Herba Lycopodii 1100g, Fructus Liquidambaris 1200g, Rhizoma Et Radix Notopterygii 1200g, Pheretima 1100g, Radix Clematidis 1200g, Radix Saposhnikoviae 1100g, Flos Carthami 1100g, Caulis Piperis Kadsurae 1200g.Add 5- The Oleum Sesami of 10 times of weight portions soaks 7-10 days；By soaked for Oleum Sesami crude drug heating extraction, big fire is boiled, after Oleum Sesami boiling Firepower reduces, endure to crude drug appearance be dark brown, internal coke yellow, pull medicinal residues out, continue to temper by medicine oil, and constantly stir Mixing, refining is to beading of dripping.By Radix Notoginseng 1500g, Radix Angelicae Dahuricae 1500g and Fructus Foeniculi 1500g, the Rhizoma Et Radix Notopterygii 1500g way of distillation is distilled into crystallization, And cross 200-300 mesh sieve after being ground into fine powder.Being put in the medicine oil tempered by the crystallization fine powder sieved, paste making agent is poured into the most afterwards In cold water, soak 5-10 days, change water every day once, releasing fire-toxin, add appropriate vaseline paste making agent.Can also obtain in aforementioned manners Ointment soak gauze, make gauze agent, every night or the free time encases at sufferer, slowly massage-1 hour half an hour.

Specific embodiment 5

The preparation method of the liniment of external is

Radix Notoginseng 1200g, Radix Angelicae Dahuricae 1300g, Fructus Foeniculi 1200g, the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into crystallization, and pulverizing is treated With, for component 1；Other raw materials Radix Dipsaci 1200g, Rhizoma Chuanxiong 1100g, Herba speranskiae tuberculatae 1200g, Herba Lycopodii 1100g, Fructus Liquidambaris 1200g, Qiang Live 1200g, Pheretima 1100g, Radix Clematidis 1200g, Radix Saposhnikoviae 1100g, Flos Carthami 1100g, Caulis Piperis Kadsurae 1200g, is soaked and has been placed in In lid stainless steel cask, adding 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement 1 hour with On, make fully to expand；After filter plate gauze bag parcel is paved bottom percolator, again the drug sample after moistening expansion is mixed pine Do to dissipate, then contain powder with rustless steel spoon, load percolator uniformly, fill 10-12 cm thick, even by T-bar pressure, then by above-mentioned behaviour Making, loading in layer, suitably pressurize, medicated powder loads 2/3 eminence that must not exceed percolator；Upper cover rustless steel hole, medicated powder face Plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Medicated powder powder to be discharged Air between Li, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open material Valve carries out percolation, controls percolation speed and is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and will Ethanol during emptying pours liquid container into；Percolate is merged and stands, stand for standby use；The filtrate of filtration is inserted economic benefits and social benefits vacuum dense In contracting device, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；Cold preservation liquid is added The filter aid kieselguhr of 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, For component 2.By component 1 and the merging of component 2, mediation substrate, sterilizing bottling cold preservation.

Pharmacological toxicity is tested

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, Shandong medical college Animal Lab. provide.

(2) test medicine: the capsule that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: take healthy mice 32, male and female half and half, divided three groups within 24 hours, gavage intestinal 0.6ml/ is only every time, and gross weight 1.8ml is equivalent to crude drug in whole 4.0g, i.e. 100g crude drug/kg/d, is equivalent to clinical 65 kilograms of people 857 times.After mice administration, feedstuff has no animal dead for 12 days and does not goes out, shows toxic reaction routinely.Hence it is demonstrated that the present invention Medicine has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the pill that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight with Machine is grouped, four groups, often group 35.1, taking test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/ d.4 groups compare the distilled water to respective volume amount, rat equal gavage enteral administration, often organize and be once used in conjunction 6 months, put to death half, remaining All death in 12 days is observed in lower 1/2 drug withdrawal.

Two, test index

(1) general status includes body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin meter Number.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: take half animal after experimental result and weigh, sacrificed by decapitation, take blood, simultaneously solution treat others for earnest, Liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with heavy dose coloclysis of the present invention six months, to rat Growth, body weight increase, all have no side effect brain, Liver and kidney function.Do not find to damage to each histoorgan, the blood circulation of rat Evil changes, and medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, delays The drug effects such as old and feeble enhancing metabolism, avirulence.

External used medicine of the present invention repeatedly Skin Irritation Test result

According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", to this Invention medicine has carried out repeatedly Skin Irritation Test.

Tested material: the unguentum of the present invention.Weigh tested material 50g to add distilled water to make 50% pastel standby.

Laboratory animal: provided Japan's white big ear rabbit 4 by Shandong University medical college Experimental Animal Center, male and female half and half, Body weight 2.5-3.0kg, primary animal (the dynamic word the 08-018th of doctor), feed resource is ibid.Animal housing's environment: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test method: test first 24 hours, in often Rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Only take tested material 0.5g/, after preparation, be coated in every rabbit one On the skin of side, smearing every day once, offside all makees solvent control.Smear 14d continuously.Every day be coated with before cropping, must not injured skin, Ensure that tested material is fully contacted with skin.Observe dermoreaction and marking every day.Off-test, takes and smears area skin and carry out disease Reason histological examination.

Experimental result: repeatedly Skin Irritation Test shows the present invention the highest stimulation index of repeatedly skin irritation and pathological tissue Integration is 0, according to skin irritation in DB61-267-1998 " health product Toxicological evaluation program and the method for inspection " Strength grading standard, the present invention repeatedly skin irritation intensity belongs to nonirritant.

Skin anaphylactic test

According to the requirement of DB61-267-1998 " health product Toxicological evaluation program and the method for inspection ", to this Invention medicine has carried out skin anaphylactic test.

Tested material: externally used paste of the present invention.Weigh tested material 10g to add distilled water to make 50% pastel standby.Positive right According to thing: 2,4-dinitro-chloro-benzenes, produce in Xing Jin chemical plant, Beijing, lot number 20020522.Laboratory animal: by Shandong University Medical college Experimental Animal Center provides Cavia porcellus 30, and male and female half and half, body weight 250-300g, primary animal, feed resource is ibid.Dynamic Thing room environmental: temperature: 22-25 DEG C, relative humidity: 45-55%.The Animal House quality certification number: the dynamic word the 08-37th of doctor.Test side Method: test Cavia porcellus is randomly divided into three groups, often group 10, male and female half and half, respectively tested material group, negative control group and the positive are right According to group.

Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3cm × 3cm. Only take tested material 0.2g/, be coated in depilation district on the left of back part of animal after preparation, continue 6 hours.7th day and fortnight, use Same method is repeated once, and positive controls is coated with 1%DNCB, and negative control group does not deals with.Excite contact: in last to tested Fortnight after thing, by tested material 0.2g/ only, is coated on depilation district on the right side of guinea pig back, removes tested material after 6 hours after preparation, At once observe anaphylaxis situation, then again observed in 1,24,48,72 hours.Positive controls is coated with 1%DNCB, negative right Do not deal with according to group.Observational technique is with tested material group.

Result of the test: skin anaphylactic test shows patch of the present invention, according to according to DB61-267-1998, " health product is pacified Full property toxicological evaluation program and the method for inspection " in relevant sensitization of skin intensity evaluation standard, the invention belongs to without sensitization.

Pharmacological experiment

One, microcirculation experimental technique:

1. materials and methods: take 50 Kunming mouses, Shandong University's biology laboratory provides.It is randomly divided into 5 groups, often group 10 (male and female half and half), it is a little that matched group every Mus auris dextra is coated with normal saline；Positive controls every Mus auris dextra gives triamcinolone acetonide note Penetrate agent 20mg, treatment group oral capsule of the present invention (preparing by embodiment institute method) solubilizer hybrid injection, test component For dosage group 600mg/kg/h in low dose group 400mg/kg/h of the present invention, the present invention, high dose 800mg/kg/h of the present invention. 15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% epinephrine 0.1mL/10g, observes mouse right ear fine motion vein bore (μm) and 0.2mm immediately²Blood capillary net number .t inspection processes real Test data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, tested group 1 has showed increased (P ＜ 0.01) to mice capillary open number；Tested group 2 right Venule bore and capillary open number dramatically increase (P ＜ 0.01)；Tested group 3 to mice fine motion, vein bore and hair Thin vessel open number all has increase (P ＜ 0.01)；Illustrate to be improved microcirculation by reagent, have function of promoting blood circulation to disperse blood clots (table 1).

Table 1, the present invention are on mice fine motion, vein bore and the impact of capillary open number

Two, externally used paste xylol of the present invention causes the impact of mice auricle swelling

Male ICR mouse 60, is randomly divided into model control group, positive controls by body weight, high, medium and low dose of the present invention Amount group, totally 5 groups, often group 12.Senior middle school low dose group rat smear respectively this product 350,250,125mg/kg, positive controls is coated with Smearing ZHENGHONGHUA YOU 125mg/kg, model group gives equal-volume normal saline, and the biggest 1 time, continuous 7 days, last was administered latter 1 hour, 50 μ l dimethylbenzene are applied to two sides before and after every mouse right ear.After 4 hours, de-neck is put to death, and cuts ears, stainless with a diameter of 8mm Steel drift sweeps away left and right auricle, weighs, using the difference of two auricle weight as weighing the index of swelling degree, antiinflammatory action intensity with Suppression ratio (%) represents, carries out statistical analysis with SPSS11.5 software kit.The results are shown in Table 2.

The table 2 impact (the x soil s) on mice ear

Compare with model control group:* p ＜ 0.01, * * * p ＜ 0.001

Test result indicate that, this product xylol causes mice auricle swelling obvious inhibiting effect, its high dose group and mould Type group compares pole significant difference.

Three. the impact of rat paw edema caused by Carrageenan

Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, ZHENGHONGHUA YOU positive controls, basis Invention spray group.Often group 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention are smeared other every day 0.2g, blank group gives the normal saline of same dosage and smears, successive administration 7 days, is administered latter 30 minutes in last, exists respectively Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ only causes inflammation, respectively at cause scorching before and cause inflammation after 15,30, 60, the girth surveying the Rat Right metapedes sole of the foot in 120,240 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching Front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%]；The results are shown in Table 3.

The impact (X ± SD) of rat paw edema caused by table 3 Carrageenan

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；Can by upper table experimental result To find out, medicine group of the present invention has the pharmacological action of blood stasis dispelling of preferably subsiding a swelling.

Talalgia is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia Also known as calcanean spur or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains, outward with old deficiency of the kidney Hinder with to experience cold-damp relevant.Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but plants destructive operation, will be with Bone posterior tibial nerve props up and props up cut-out with sural nerve, has side effect in various degree or causes some complication；Chinese medicine product is then Because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.Medicine of the present invention is made For local, permeate skin, through sick institute, promote qi and blood circulation, improve local blood and run, soften bony spur, promote that inflammation is inhaled Receive, so that remission or elimination.Oral administration and externally of the present invention, can effectively expand peripheral vessel, improves foot's microcirculation, detumescence Blood stasis dispelling, activating collaterals to relieve pain effect is obvious.

Clinical research

Heel pain is more common in middle-aged and elderly people, and the lighter's only heel pain when walking, severe one is suffered from foot and landed i.e. bitterly, it is impossible to OK Walking or stand, foot also pain suffered from by pendency, very painful.Treating this disease, seldom effective with rheumatism analgesic, closed treating is treated long term Heterodyne.The author uses Chinese medicine external to coordinate this disease 56 example of the dialectical orally taken for curing of Chinese medicine in recent years, obtains effect preferably, is now reported as follows.

1 clinical data

Whole 56 examples are out-patient, the maleest 21 examples, female 35 example；Less than 30 years old age, 3 examples, 30-50 year 41 examples, 50 More than year 12 examples；Monopodia calcaneodynia 43 example, biped calcaneodynia 13 example；The course of disease is the shortest 1 month, the longest 11 months.X-ray checks that 47 are suffered from foot Hyperosteogeny is had to be formed.

Therapeutic Method

Chinese medicine fumigation and washing medicine forms: Radix Dipsaci 15g, Radix Angelicae Dahuricae 13g, Fructus Foeniculi 12g, Rhizoma Chuanxiong 13g, Herba speranskiae tuberculatae 12g, Radix Notoginseng 13g, Herba Lycopodii 15g, Fructus Liquidambaris 12g, Rhizoma Et Radix Notopterygii 12g, Pheretima 13g, Radix Clematidis 12g, Radix Saposhnikoviae 13g, Flos Carthami 12g, Caulis Piperis Kadsurae 15g, vinegar 250ml。

Usage: front 14 taste medicines add cold water 3000mL, soaks 1～2h, boils 30～40min, pour in basin, add Natrii Sulfas, Vinegar stirs evenly.First fumigate affected part with steam, when water temperature is not scalded, soak Xian affected part.Can reheat during water temperature drop, during each fumigation and wash method Between no less than 1h, the most each 1 time.1 dose of medicine can use 2d.

Qi stagnation and blood stasis type talalgia show themselves in that a variety of causes cause local blood slowly, stagnation of blood stasis, venation is hindered, then QI-blood circulation is smooth and pain, and localized pain, pain with tenderness, walks limited.Treat suitable warming and recuperating the kidney-YANG, replenishing essence is enriched blood, with this Bright endo-medicine is treated, Fang Yong: Radix Astragali 12g, Rhizoma Dioscoreae 14g, Fructus Psoraleae 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Pubescentis 13g, Radix Polygoni Multiflori Preparata 12g, Radix Achyranthis Bidentatae 12g, Flos Carthami 13g, Fructus Lycii 13g, Radix Angelicae Sinensis 12g, Herba Ecliptae 13g, Rhizoma Cyperi 12g, Radix Bupleuri 13g, Rhizoma Drynariae 12g, Cortex Eucommiae 12g, Rhizoma Corydalis Rope 12g, Caulis Spatholobi 13g.Being prepared as granule by embodiment 2, every day, three guarantees were taken after mixing it with water.

Observation of curative effect

Talalgia, according to the state of an illness and clinical examination, is divided into 5 grades by Pain Grading.0 grade: heel portion unit tenderness, walking Same normal person；Level: mild pain during heel portion weight, can normally walk；2 grades: during heel portion weight, pain is obvious, ache during walking Bitterly；3 grades: when heel portion is gently pressed, pain is obvious, slight swelling, slightly pace row, 4 grades: sharp ache when heel portion is gently pressed, hence it is evident that swollen Swollen, need cane walk help, or it is difficult to walk.

Therapeutic outcome is originally organized in 69 pain heels of 56 example, treats front 1 grade 1 (1.45%), 2 grades 9 (13.04%), 3 46 (66.67%) of level, 4 grades 13 (18.84%).Treat latter 3 months and follow up a case by regular visits to, 0 grade 51 (73.91%), progressive one-level with Upper but not up to 0 grade totally 14 (20.29%), without improving 4 (5.79%).

Chinese medicine is thought, caused by talalgia many genus hepatic and renal YIN deficiency.Liver governing tendons, kidney governing bones, caused by liver and kidney deficiency, muscles and bones is lost and is supported, multiple Sense wind-cold damp pathogen or chronic strain, cause meridian stasis stagnant, and QI-blood circulation is obstructed, and muscles and bones muscle loses supports and fall ill.Fumigation and wash method Fang Zhongchuan Disconnected, Radix Clematidis, Herba speranskiae tuberculatae, Caulis Spatholobi expelling wind and cold, dredge the meridian passage；Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Angelicae Dahuricae promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons；River Radix Dipsaci, Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening；Pheretima hard masses softening and resolving, reducing swelling and alleviating pain；Vinegar ion Han vinegar, has stronger osmosis, can Help the power of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Fumigation and wash method decocted by all liquid medicine, and medicine acts on local, permeates skin, through sick institute, promotes gas Blood flow leads to, and improves local blood and runs, softens bony spur, promotes that inflammation absorbs, so that remission or elimination.

" Zhang Shi doctor logical " cloud: " kidney storing essence, deficiency of YIN person, then foot shin heat and talalgia, pill of Six Ingredients adds Carapax et Plastrum Testudinis, Cortex Cinnamomi, yang deficiency Person, then can not standing for a long time and talalgia, eight taste balls." heel pad fat is scorching in calcaneodynia, in the majority with elderly patient, has kidney yang not more Foot performance.Patient's heel cold type of pain, conscious without foot pad, just as bone is directly stepped on, it is impossible to stand for a long time, squat for a long time, this is that old people is with pad Atrophy, thinning caused, clinical treat with Yougui Wan, the kidney-Yang-Reinforcing Bolus, with warming and recuperating the kidney-YANG, replenishing essence is enriched blood；Hold concurrently cold-damp person, adds Fructus Psoraleae and leads to blood with temperature Arteries and veins, adds Rhizoma Drynariae with except bottom cold-damp.Calcaneal bursitis, plantar aponeurositis, peritenonitis of achilles tendon and calcanean spur, such dialectical use Medicine, Chinese medicine, quite closes the pathological characteristic of this disease, therefore obtains good effect.

Claims

1. the preparation method treating qi stagnation and blood stasis type talalgia Chinese medicine composition, it is characterised in that described Chinese medicine composition Including endo-medicine and external used medicine；Described endo-medicine is pill, and its preparation method comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving；

D. by 2-in-1 to component 1 and component also, decompression recycling ethanol is also spray-dried, and obtains medicated powder；Mix the fine powder and honeybee obtained that sieve Honey is twisted into pill.

Treat the preparation method of qi stagnation and blood stasis type talalgia Chinese medicine composition the most according to claim 1, it is characterised in that institute State in step a, described crude drug is put into after pulverizer is pulverized and cross 120 mesh dusting covers, enable and reached by the fine powder amount of 120 mesh sieves To 20%, collect standby by the raw material fine powder of 120 mesh sieves.

Treat the preparation method of qi stagnation and blood stasis type talalgia Chinese medicine composition the most according to claim 1, it is characterised in that institute Stating in step b, after sieving, remaining coarseparticulate puts into heating and refluxing extraction 2 times in ethanol, each 1～2 hour, by 2 times Extracting solution merges standing, goes supernatant, united extraction liquid, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, super The extractum of 1.36 when filtrate reduced in volume relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1.

Treat the preparation method of qi stagnation and blood stasis type talalgia Chinese medicine composition the most according to claim 1, it is characterised in that institute State in step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added weight 10 times amount water heating and refluxing extraction 2 times, each 1～2 hour, will 2 times extracting solution merge standing, go supernatant, united extraction liquid, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, The extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 2.

Treat the preparation method of qi stagnation and blood stasis type talalgia Chinese medicine composition the most according to claim 1, it is characterised in that institute State in step d, by 2-in-1 also to said components 1 and component, insert after decompression recycling ethanol in economic benefits and social benefits vacuum concentrator, be concentrated into 90 DEG C time relative density be the extractum of 1.36, be concentrated into every 1ml crude drug amount Han 0.1g, then pass to spray dryer and carry out spray dried Dry, the compressed air pressure crossing spray dryer shower nozzle is 5kg/m², hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder； The raw material fine powder obtained after sieving mixes with raw material medicated powder, adds Mel and is twisted into pill.

6. the preparation method of a treatment qi stagnation and blood stasis type talalgia Chinese medicine composition, it is characterised in that described medicine for external use Agent type is unguentum, and its preparation process is: added by the raw medicinal material of above-mentioned ratio of weight and number in the Oleum Sesami of 5-10 times of weight portion Soaking 7-10 days, heating, big fire boils, and after Oleum Sesami boiling, firepower reduces, endure to pharmaceutical presentations be dark brown, internal coke yellow, Pulling medicinal residues out, continue to temper by medicine oil, and be stirred continuously, refining is to beading of dripping；Plumbum preparatium is fried to vermilion, removes moisture, mistake 100-120 mesh sieve removes impurity；Plumbum preparatium is slowly added in the medicine oil refined, is stirred continuously, become the thick paste of black, the cream refined It is poured in cold water after medicine is the coldest, soaks 5-10 days, change water every day once, releasing fire-toxin；Paste making agent.

7. the Chinese medicine composition treating qi stagnation and blood stasis type talalgia, it is characterised in that described Chinese medicine composition includes taking orally Medicine and external used medicine；

Described endo-medicine includes the crude drug of following parts by weight: the Radix Astragali 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Fructus Psoraleae 10～ 20 parts, Radix Rehmanniae Preparata 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Ecliptae 10～20 parts, Rhizoma Cyperi 10～20 parts, Radix Bupleuri 10～20 parts, Rhizoma Drynariae 10～20 Part, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts；

Described Chinese medicine composition external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Fructus Foeniculi 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Herba Lycopodii 10～20 parts, Fructus Liquidambaris 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Pheretima 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts, Flos Carthami 10～20 parts, Caulis Piperis Kadsurae 10～20 parts.

Treat the Chinese medicine composition of qi stagnation and blood stasis type talalgia the most according to claim 7, it is characterised in that

Described endo-medicine includes the crude drug of following parts by weight: the Radix Astragali 10～15 parts, Rhizoma Dioscoreae 10～15 parts, Fructus Psoraleae 10～ 15 parts, Radix Rehmanniae Preparata 10～15 parts, Radix Angelicae Pubescentis 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Achyranthis Bidentatae 10～15 parts, Flos Carthami 10～15 parts, Fructus Lycii 10～15 parts, Radix Angelicae Sinensis 10～15 parts, Herba Ecliptae 10～20 parts, Rhizoma Cyperi 10～20 parts, Radix Bupleuri 10～20 parts, Rhizoma Drynariae 10～20 Part, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts；

Described external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Fructus Foeniculi 10～ 15 parts, Rhizoma Chuanxiong 10～15 parts, Herba speranskiae tuberculatae 10～15 parts, Radix Notoginseng 10～15 parts, Herba Lycopodii 10～15 parts, Fructus Liquidambaris 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Pheretima 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts, Flos Carthami 10～20 parts, Caulis Piperis Kadsurae 10～ 20 parts.

Described endo-medicine includes the crude drug of following parts by weight: the Radix Astragali 10～20 parts, Rhizoma Dioscoreae 10～20 parts, Fructus Psoraleae 10～ 20 parts, Radix Rehmanniae Preparata 10～20 parts, Radix Angelicae Pubescentis 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Ecliptae 10～15 parts, Rhizoma Cyperi 10～15 parts, Radix Bupleuri 10～15 parts, Rhizoma Drynariae 10～15 Part, the Cortex Eucommiae 10～15 parts, Rhizoma Corydalis 10～15 parts, Caulis Spatholobi 10～15 parts；

Described Chinese medicine composition external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Fructus Foeniculi 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Herba Lycopodii 10～20 parts, Fructus Liquidambaris 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Pheretima 10～15 parts, Radix Clematidis 10～15 parts, Radix Saposhnikoviae 10～15 parts, Flos Carthami 10～15 parts, Caulis Piperis Kadsurae 10～15 parts.

10., according to the Chinese medicine composition for the treatment of treatment qi stagnation and blood stasis type talalgia according to any one of claim 7～9, it is special Levying and be, described endo-medicine dosage form is: sugar coated tablet, film coated tablet, hard capsule, soft capsule, oral liquid, granule Agent, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster, powder or slow releasing capsule；Described medicine for external use agent Type is: spray, ointment, tincture, unguentum, patch, herbal fumigation agent or Local out dressing gauze agent.