CN105997601A - Additive in moisture-preserving skin care product and production technology thereof - Google Patents

Additive in moisture-preserving skin care product and production technology thereof Download PDF

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Publication number
CN105997601A
CN105997601A CN201610438564.2A CN201610438564A CN105997601A CN 105997601 A CN105997601 A CN 105997601A CN 201610438564 A CN201610438564 A CN 201610438564A CN 105997601 A CN105997601 A CN 105997601A
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Prior art keywords
parts
additive
moisturizer
emulsifying pot
care product
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CN201610438564.2A
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Chinese (zh)
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况海滨
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Individual
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Individual
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Priority to CN201610438564.2A priority Critical patent/CN105997601A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a formula of an additive in a skin care product, in particular to a composition needing to be added into a skin care product with the moisture preserving function and a production technology thereof. According to the composition, natural moisturizing factors of the skin cuticle are simulated from the point of bionics. The additive of the skin care product with the moisture preserving effect is prepared from, by weight, 93.5-148 parts of amino acid, 25-38 parts of pyrrolidone carboxylic acid, 10-20 parts of lactate, 5-15 parts of urea, 12 parts of inorganic salt, 2 parts of citrate, 340 parts of polyhydric alcohol and 450-460 parts of deep-sea rock stratum water in a compounded mode. Compared with natural ingredients in the cuticle, the additive, prepared in the technical scheme, of the moisture-preserving skin care product has the advantages that the content of the effective components is higher, the long-acting moisture preserving effect and the anti-oxidation effect can be achieved, and the preparing technology is simple, easy to operate and suitable for industrial large-scale production.

Description

Additive in a kind of Moisturizer and production technology thereof
Technical field
The present invention relates to the additive formula in a kind of skin care item, be specifically related to a kind of there is protecting of moisture-keeping functions Skin product need compositions and the production technology thereof added.
Background technology
The skin of the mankind is encroached on from the external world just like one barrier, protection intracorporeal organ.Skin mainly by epidermal area, Skin corium and subcutaneous tissue three part are constituted.Wherein epidermal area is outmost one layer of skin, and ecto-entad is divided into Five layers, be horny layer, clear layer, granular layer, prickle cell layer and basal layer, as shown in Figure 1 successively.
Horny layer, as a successional barrier, is mainly made up of horn cell and intercellular substance.Wherein, angle Cell plastid contains abundant keratin and nature moisturizing factor (NMF).Cuticular enlarged diagram and structure Schematic diagram is as shown in accompanying drawing 2,3.
The composition of nature moisturizing factor (NMF) is as shown in table 1, and it is responsible for the vital task of skin moisture-keeping, Mainly contain aminoacid, lactate and mineral salt.If above composition lacks or deficiency, the colour of skin can be caused dark Heavy, produce microgroove and become dry, sensitive.Wherein, the aminoacid in horny layer is arginine, Aspartic Acid, Glutamic acid, valine, leucine, isoleucine, serine, glycine, alanine, proline etc. 17 Plant aminoacid.
Table 1 nature moisturizing factor forms
Summary of the invention
The present invention is to imitate the nature moisturizing factor of keratodermatitis from bionics angle, counts by weight Calculate by aminoacid 93.5-148 part, 2-pyrrolidone-5-carboxylic acid's 25-38 part, lactate 10-20 part, carbamide 5-15 part, nothing Machine salt 12 parts, citrate 2 parts, polyhydric alcohol 340 parts and rock stratum, deep-sea water 450-460 part are compound prepares one There is the skin care item additive of moistening effect, trade name Idealface.
Further, in the present invention, particular make-up and the parts by weight of additive are: tyrosine 3-7 part, Radix Asparagi Propylhomoserin 8-14 part, valine 3-6 part, leucine 5-11 part, isoleucine 2-6 part, serine 15-23 part, sweet Propylhomoserin 32-38 part, alanine 5-8 part, histidine 1.5-3 part, proline 3-6 parts, glutamic acid 9-13 part, essence ammonia Acid 4-7 part, phenylalanine-3,4-quinone-6 parts, 2-pyrrolidone-5-carboxylic acid's 25-38 part, sodium lactate 10-20 part, carbamide 5-15 part, 3 parts of magnesium chloride, 9 parts of sodium chloride, sodium citrate 2 parts, 1,3 butylene glycol 140 parts, glycerol 200 parts and deep-sea Rock stratum water 450-460 part.
In the present invention, the technological process of production of additive is as follows:
(1) by rock stratum, deep-sea water, glycerol and 1,3 butylene glycol are sequentially added in emulsifying pot, and stirring is warming up to 90 ℃；
(2) emulsifying pot is cooled to 70 DEG C, weigh various aminoacid according to formula composition, be sequentially added into emulsifying Pot is evenly stirred until powder and is completely dissolved；
(3) 2-pyrrolidone-5-carboxylic acid, sodium lactate and carbamide are added in emulsifying pot, stir；
(4) again emulsifying pot is cooled to 40 DEG C, is subsequently adding magnesium chloride, sodium chloride and sodium citrate and fills Divide stirring all；
(5) detect qualified, filter charging.
In the formula of the present invention, 13 kinds of aminoacid, in skin except moisture-keeping function, also each play other Different effects.Glycine, proline, alanine are the constituent of collagen protein and elastin laminin；Radix Asparagi Propylhomoserin, serine, tyrosine are the constituent of Skin Cell, can promote metabolism and the increasing of Skin Cell Grow；Glutamic acid strengthens Skin Cell immunity；Histidine and phenylalanine are effective against ultraviolet；Carbamide (carbon Acid diamide) other compositions can be helped to permeate, antiinflammatory, antipruritic, moisturizing skin, and can strengthen cuticular Moistening effect.
Rock stratum, the one of which component deep-sea water of additive of the present invention, the method taking vertically to beat deep-well at offshore, Later stage in the Paleozoic Era rock stratum of underground 500-1500 rice benthos is picked up from pick, is deep-sea water landwards the most natural rock Layer transition, and rock stratum, the deep-sea water that rock vertical natural transition infiltration produces；It contains plurality of inorganic salt, mineral Matter and trace element, be more beneficial for the nursing of skin.Detect through Fudan University in Shanghai Institute of Analysis, deep-sea Rock stratum water be water clusters structure be 58Hz, and the micel structure of terrestrial water is 140Hz, and water clusters is more Little, the particle diameter of water is the least, the easiest is absorbed by human skin so that it is have a high penetration, high diffusivity power, High dissolving power.Again, rock stratum, deep-sea water is in without photosphere throughout the year, occurs without photosynthesis, not by land with big Chemistry material and various pathogen contamination, it is ensured that water quality is the purest.The interpolation of these compositions can make raw material have Significantly moisturizing, is easily absorbed by the skin, and promotes cell proliferation, and antioxidative effect.
According to the additive in a kind of Moisturizer that the technical program is prepared, compared with the sky in horny layer So composition, active component content is higher, can not only play long-acting moisturizing and antioxidative effect, and preparation technology Simple to operation, it is suitable for industrialization large-scale production.
Accompanying drawing explanation
Fig. 1 behaves body surface chrotoplast structure chart；
Fig. 2 is cuticular enlarged diagram；
Fig. 3 is cuticular structural representation；
Accompanying drawing 1-3 marks: 10-epidermis, 20-corium, 11-horny layer, 12-clear layer, 13-granular layer, 14-spine are thin Born of the same parents' layer, 15-basal layer, 11a-nature moisturizing factor (NMF), 11b-sebum film, 11c-horn cell, 11d- Intercellular lipid, 11e-moisture.
After Fig. 4 is the cosmetic water using and containing embodiment 1, skin condition change correlation curve figure；
After Fig. 5 is the cosmetic water using and containing embodiment 1, left and right cheek keratodermatitis change of moisture content trend；
After Fig. 6 is the cosmetic water using and containing embodiment 1, left and right cheek percutaneous water loss amount variation tendency.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is conducted further description.
Embodiment 1
1. 455 parts of rock stratum, deep-sea water, glycerol 200 parts and 1,3 butylene glycol 140 parts are sequentially added in emulsifying pot, Stir and be warming up to 90 DEG C；
2. emulsifying pot is cooled to 70 DEG C, weighs tyrosinase 15 part, aspartic acid 12 parts, valine 4.5 parts, bright Propylhomoserin 7 parts, isoleucine 4 parts, serine 20 parts, glycine 37 parts, alanine 6.5 parts, histidine 2.5 Part, proline-4 .5 part, 10 parts of glutamic acid, arginine 6 parts, phenylalanine 5 parts, be sequentially added into emulsifying pot, It is evenly stirred until powder to be completely dissolved；
3. 2-pyrrolidone-5-carboxylic acid 38 parts, sodium lactate 15 parts and 15 parts of carbamide are added in emulsifying pot, be sufficiently stirred for Uniformly；
The most again emulsifying pot is cooled to 40 DEG C, is subsequently adding 3 parts of magnesium chloride, 9 parts of sodium chloride and sodium citrate 2 parts are sufficiently stirred for all；
5. detection is qualified, filters charging.
The additive prepared in embodiment carries out the both effectiveness test of skin, and volunteer uses every day to be contained The cosmetic water of this additive applies face about 10 minutes, respectively the 0th, 5,10,15 day used to aspiration Person's change of skin carries out 4 assessments.Fig. 4 be use before with a couple of days after the dry stricture of vagina of skin surface, decortication phenomenon Correlation curve figure, it can be seen that after employing the cosmetic water containing additive of the present invention, under decortication index is obvious Fall, illustrates that the state of skin has had bigger improvement.Fig. 5 is the trend of left and right cheek keratodermatitis water content Figure, Fig. 6 is the water loss amount trendgram of left and right cheek skin, two figures can be seen that along with using sky Number increase, the cosmetics containing additive of the present invention for continuous skin moisturizing effect clearly.
Embodiment 2
1. 450 parts of rock stratum, deep-sea water, glycerol 200 parts and 1,3 butylene glycol 140 parts are sequentially added in emulsifying pot, stir Mix and be warming up to 90 DEG C；
2. emulsifying pot is cooled to 70 DEG C, weighs 3 parts of tyrosine, aspartic acid 8 parts, valine 3 parts, bright ammonia Acid 5 parts, isoleucine 2 parts, serine 15 parts, glycine 32 parts, alanine 8 parts, histidine 3 parts, Proline 6 parts, 13 parts of glutamic acid, arginine 7 parts, phenylalanine 6 parts, secondary addition emulsifying pot, stirring is all Even it is completely dissolved to powder；
3. 2-pyrrolidone-5-carboxylic acid 25 parts, sodium lactate 10 parts and 15 parts of carbamide are added in emulsifying pot, be sufficiently stirred for Uniformly；
The most again emulsifying pot is cooled to 40 DEG C, is subsequently adding 3 parts of magnesium chloride, 9 parts of sodium chloride and sodium citrate 2 parts are sufficiently stirred for all；
5. detection is qualified, filters charging.
Embodiment 3
1. 460 parts of rock stratum, deep-sea water, glycerol 200 parts and 1,3 butylene glycol 140 parts are sequentially added in emulsifying pot, stir Mix and be warming up to 90 DEG C；
2. emulsifying pot is cooled to 70 DEG C, weighs 7 parts of tyrosine, aspartic acid 14 parts, valine 6 parts, bright ammonia Acid 11 parts, isoleucine 6 parts, serine 23 parts, glycine 38 parts, alanine 5 parts, histidine 1.5 parts, Proline 3 part, 9 parts of glutamic acid, arginine 4 parts, phenylalanine-3,4-quinone part, be sequentially added into the stirring of emulsifying pot all Even it is completely dissolved to powder；
3. 2-pyrrolidone-5-carboxylic acid 38 parts, sodium lactate 20 parts and 5 parts of carbamide are added in emulsifying pot, be sufficiently stirred for Uniformly；
The most again emulsifying pot is cooled to 40 DEG C, is subsequently adding 3 parts of magnesium chloride, 9 parts of sodium chloride and sodium citrate 2 parts are sufficiently stirred for all；
5. detection is qualified, filters charging.

Claims (6)

1. the additive in a Moisturizer, it is characterised in that: its component is according to weight portion Number calculating includes aminoacid 93.5-148 part, 2-pyrrolidone-5-carboxylic acid's 25-38 part, lactic acid Salt 10-20 part, carbamide 5-15 part, inorganic salt 12 parts, citrate 2 parts, many Unit's alcohol 340 parts and rock stratum, deep-sea water 450-460 part.
Additive in a kind of Moisturizer the most as claimed in claim 1, it is characterised in that: Described amino acid whose composition and parts by weight are tyrosine 3-7 part, aspartic acid 8-14 Part, valine 3-6 part, leucine 5-11 part, isoleucine 2-6 part, serine 15-23 part, glycine 32-38 part, alanine 5-8 part, histidine 1.5-3 part, Proline 3-6 parts, glutamic acid 9-13 part, arginine 4-7 part, phenylalanine-3,4-quinone-6 Part.
Additive in a kind of Moisturizer the most as claimed in claim 1, it is characterised in that: Described lactate is sodium lactate, and citrate is sodium citrate.
Additive in a kind of Moisturizer the most as claimed in claim 1, it is characterised in that: Described inorganic salt is 3 parts of magnesium chloride and 9 parts of sodium chloride.
Additive in a kind of Moisturizer the most as claimed in claim 1, it is characterised in that: Described polyhydric alcohol is 1,3 butylene glycol 140 and glycerol 200 parts.
6. the production technology of the additive in a Moisturizer, it is characterised in that flow process is as follows:
(1) by rock stratum, deep-sea water, glycerol and 1,3 butylene glycol are sequentially added in emulsifying pot, stirring It is warming up to 90 DEG C；
(2) emulsifying pot is cooled to 70 DEG C, weigh various aminoacid, pyrrole according to formula composition Pyrrolidone carboxylic acid, sodium lactate and carbamide, be sequentially added into emulsifying pot and be evenly stirred until and be completely dissolved；
(3) again emulsifying pot is cooled to 40 DEG C, be subsequently adding magnesium chloride, sodium chloride and Sodium citrate is sufficiently stirred for all；
(4) detect qualified, filter charging.
CN201610438564.2A 2016-06-18 2016-06-18 Additive in moisture-preserving skin care product and production technology thereof Pending CN105997601A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610438564.2A CN105997601A (en) 2016-06-18 2016-06-18 Additive in moisture-preserving skin care product and production technology thereof

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Application Number Priority Date Filing Date Title
CN201610438564.2A CN105997601A (en) 2016-06-18 2016-06-18 Additive in moisture-preserving skin care product and production technology thereof

Publications (1)

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CN105997601A true CN105997601A (en) 2016-10-12

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011042588A (en) * 2009-08-19 2011-03-03 Kenzo Ito Moisturizing cosmetic
CN105662913A (en) * 2015-12-31 2016-06-15 杭州心悦化妆品有限公司 High moisturizing toner

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011042588A (en) * 2009-08-19 2011-03-03 Kenzo Ito Moisturizing cosmetic
CN105662913A (en) * 2015-12-31 2016-06-15 杭州心悦化妆品有限公司 High moisturizing toner

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Application publication date: 20161012