CN105997342B - A kind of vision prosthesis of retina inner membrance - Google Patents
A kind of vision prosthesis of retina inner membrance Download PDFInfo
- Publication number
- CN105997342B CN105997342B CN201610537333.7A CN201610537333A CN105997342B CN 105997342 B CN105997342 B CN 105997342B CN 201610537333 A CN201610537333 A CN 201610537333A CN 105997342 B CN105997342 B CN 105997342B
- Authority
- CN
- China
- Prior art keywords
- light
- visual stimulus
- inner membrance
- retina
- chip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of vision prosthesis of retina inner membrance, include external controller, Ligation in vitro cable, external transmitting antenna, Receiver in body, internal connecting cable and visual stimulus chip, visual stimulus chip is photosensor chip, it is placed on retina inner membrance, the electric signal of generation directly stimulates the optic cell of retina inner membrance.The present invention have many advantages, such as directly parallel stimulation optic cell, without the conversion of additional electric signal, it is flexible extend, it is compatible preferable with the original optical system of human eye.
Description
Technical field
The present invention relates to photoelectron technical field more particularly to a kind of vision prosthesis of retina.
Background technique
Retinal photoreceptor cells lesion, such as retinal pigment degeneration, aging maculopathy, be the day after tomorrow blinding it is important
Reason medically there is no effective treatment method at present.In the patient of these blindings, although in quite a few retina
Photosensory cell be badly damaged, but the electric signal transmissions such as optic nerve channel is relatively intact.If can be in the front end of optic nerve position
It sets, is implanted into electronic device, generate electric signal that is mutually compatible with human body optic nerve system, reacting incident light distribution, thus shape
At equivalent vision prosthesis, the blind person of retinal photoreceptor cells lesion can be allowed to generate a degree of equivalent vision, significantly
Improve the quality of life of these patients.
Currently, retinal visual prosthese is broadly divided into following two major classes: one, retina inner membrance (Epiretinal) vision
Prosthese, with two generation of Argus (ARGUS II) of Second Sight Medical company of U.S. production for representative.It includes
It is external camera, external processing and supply unit, external serial cable, external transmission antenna, internal receiving antenna, serial in vivo
Cable, in vivo processing and supply unit and stimulating electrode array etc..Extraneous optical signal is converted into representative figure by external camera
As the electric signal of distribution, electric signal is transmitted to external hair by a serial cable under external processing and the control of power supply unit
Antennas, external transmission antenna wirelessly send the serial signal of energy and representative image in vivo, receive in vivo
Antenna receives the serial signal of energy and representative image, is sent under the control of built-in acceptor circuit by internal serial cable
To the stimulating electrode array positioned at retina inner membrance, and be converted to the parallel electric signal of stimulating electrode array.Existing retina
The major advantage of inner membrance vision prosthesis is: electrod-array directly contacts the optic cell of retina inner membrance, even if patient's view
Other types of cell (such as photosensory cell, Beale's ganglion cells, the amakrine and horizontal cell) function of film is lost, retina
Inner membrance vision prosthesis can also help patient to generate vision in principle.Existing main problem is: the figure of 1. external cameras shooting
As signal, the conversion twice by parallel-to-serial and serial-to-parallel is needed, causes vision prosthesis telecommunications to a great extent
Number to external optical signals response delay.2. photosensitive element is external, patient cannot re-use optical system (such as glass of human eye
Body, pupil, ciliary muscle etc.) reaction of the realization to incident field, and normally opthalmic optics' system is incompatible.
Two, epi-retinal membrane (Subretinal) vision prosthesis, the Alpha produced with German Retina Implant company
IMS is representative.It includes external processing and supply unit, external transmitting antenna, internal receiving antenna, controls and energize single in vivo
Member, visual stimulus chip.Visual stimulus chip is placed on the epi-retinal membrane position of photosensory cell disabler, the photoelectricity for including
The array of detector, amplifier and stimulating electrode, external optical signals project visual stimulus by the original optical system of eyes
Optical field distribution is concurrently converted to the electric signal point of image by the position of chip, the photodetector array in visual stimulus chip
Cloth, amplifier array amplify the electric signal of photodetector array, and the Beale's ganglion cells of retina is stimulated by electrod-array, so
Electric signal passes sequentially through the amakrine and horizontal cell of retina afterwards, eventually arrives at optic cell.Existing retina
The main advantage of outer membrane vision prosthesis is: 1. is preferable with the original optical system compatibility of human eye, due in visual stimulus chip
Set optical system (such as vitreum, the pupil, ciliary muscle) realization pair that human eye can be re-used in original retinal location
The reaction of incident field.2. light field signal is directly converted into electric image signal by visual stimulus chip, directly, view is concurrently stimulated
The relevant cell of nethike embrane avoids response delay caused by the conversion of the electric signals such as parallel-to-serial and serial-to-parallel.Major defect
It is: it is higher to the integrity demands of retina cell, other than allowing photosensory cell disabler, it is desirable that other classes of retina
The cell (such as Beale's ganglion cells, amakrine and horizontal cell) of type is fully functional, is otherwise difficult to generate effective vision.
Summary of the invention
The purpose of the present invention is intended to solve one of above-mentioned vision prosthesis at least to a certain extent.
For this purpose, it is an object of the invention to propose a kind of vision prosthesis of retina inner membrance.The present invention can be directly parallel
Stimulate optic cell and the original optical system compatibility of human eye preferably.
In order to achieve the above object, a kind of vision prosthesis for retina inner membrance that embodiment proposes according to a first aspect of the present invention,
Include external controller, Ligation in vitro cable, external transmitting antenna, Receiver in body, internal connecting cable and visual stimulus core
Piece, it is characterised in that: the visual stimulus chip is photosensor chip, is placed on the position of retina inner membrance, the electric signal of generation
Directly stimulate the optic cell of retina inner membrance.
The vision prosthesis for the retina inner membrance that the embodiment of the present invention proposes, is placed on retina for photosensitive visual stimulus chip
The position of inner membrance, the electric signal of generation directly stimulate the optic cell of retina inner membrance, and thus, it is possible to directly parallel stimulation views
Nerve cell, without the conversion of additional electric signal, it is flexible extend, with human eye original optical system compatibility preferably.
In addition, the vision prosthesis of retina inner membrance according to the above embodiment of the present invention can also have following additional skill
Art feature:
In some instances, the visual stimulus chip is the two-dimensional array device comprising multiple light-operated electric pulse generators
Part, wherein each light-operated electric pulse generator generates the electric impulse signal compatible with optic nerve according to incident light, is irradiated to
The light of the light-operated electric pulse generator is stronger, and the frequency of the electric impulse signal of generation is higher.
In some instances, the light-operated electric pulse generator of each of described visual stimulus chip includes: photodetector, will
Incident optical signal is converted into voltage signal, and incident light is stronger, and the output voltage variation of the photodetector is faster；Schmidt's touching
It sends out device and exports corresponding trigger voltage as the light-operated electricity using the output voltage of the photodetector as input voltage
The output of impulse generator；Voltage controlled current source, according to the output voltage of the Schmidt trigger to the photodetection
Device both ends carry out charge and discharge, realize the feedback control to the output voltage of the photodetector；Stimulating electrode, one end connect institute
The output end of Schmidt trigger is stated, the other end directly contacts the optic cell of retina inner membrance.
In some instances, photodetector, the Shi Mi of the light-operated electric pulse generator of each of described visual stimulus chip
The functional layer of special trigger and voltage controlled current source is inorganic semiconductor and metal material, has been made in inorganic semiconductor substrate
It is transferred in flexible substrate after finishing.
In some instances, the visual stimulus chip, internal connecting cable, internal controller are by flexible, corrosion-resistant material
Expect substrate sealing, the shape of the visual stimulus chip can carry out bending extension according to the shape of retina.The internal control
Device processed is sealed by flexible, resistant material, forms the shape of similar capsule.
In some instances, the visual stimulus chip is flexible, transparent by two panels, the sealing of resistant material substrate, wherein
The photodetector, Schmidt trigger and voltage controlled current source are located therein the inner surface of a piece of substrate, described another
The punching of piece substrate, the stimulating electrode array fill the hole array of another substrate, one end and Schmidt trigger array
Output end in contact, the other end and optic nerve contact.
In some instances, the Schmidt trigger of the light-operated electric pulse generator of each of described visual stimulus chip is not by
More than 6 field-effect tube compositions, voltage controlled current source are formed by being no more than 2 field-effect tube.
In some instances, the functional layer of the light-operated electric pulse generator of each of described visual stimulus chip is silicon semiconductor
And metal electrode, it makes on a silicon substrate, has silicon between the silicon substrate and the functional layer of the light-operated electric pulse generator
Sacrificial layer of the nitrogen oxides as shifting process.
In some instances, the functional layer of each of described visual stimulus chip optical detector of light-operated electric pulse generator
It for GaAs base epitaxial layer and metal electrode, makes on gaas substrates, the GaAs of the GaAs substrate and the photodetector
There is sacrificial layer of the AlAs shifting process between base epitaxial layer.
The additional aspect of the present invention and advantage will be set forth in part in the description, and will partially become from the following description
Obviously, or practice through the invention is recognized.
Detailed description of the invention
Above-mentioned and/or additional aspect of the invention and advantage will become from the description of the embodiment in conjunction with the following figures
Obviously and it is readily appreciated that, in which:
Fig. 1 is the system block diagram and visual stimulus chip of the vision prosthesis of the retina inner membrance of one embodiment of the invention
Structural schematic diagram and the relative position in retina；
Fig. 2 is the light-operated electric pulse generator of each of visual stimulus chip of retina inner membrance of one embodiment of the invention
Principle electrical circuit figure；
Fig. 3 is the light-operated electric pulse generator of each of visual stimulus chip of retina inner membrance of one embodiment of the invention
A kind of possible MOS grades of circuit diagram；
Fig. 4 is that the light-operated electric pulse of each of visual stimulus chip of retina inner membrance of another embodiment of the present invention occurs
A kind of possible MOS grades of circuit diagram of device.
Specific embodiment
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end
Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached
The embodiment of figure description is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention.
Below with reference to the accompanying drawings the light-operated electric pulse generator array device of the embodiment of the present invention is described.
Fig. 1 is the system block diagram and visual stimulus chip of the vision prosthesis of the retina inner membrance of one embodiment of the invention
Structural schematic diagram and the relative position in retina；
The vision prosthesis of retina inner membrance proposed by the present invention includes external controller 1, Ligation in vitro cable 2, external hair
Penetrate antenna 3, Receiver in body 4, internal connecting cable 5 and visual stimulus chip 6.7 be retina, 7a, 7b for being included, 7c,
7d, 7e, 7f, 7g and 7h are respectively optic cell, gangliocyte, amakrine, Beale's ganglion cells, level in retina
Cell, cone cell, rod cell and pigment epithelial cell.Wherein the effect of external controller 1 is to adjust visual stimulus chip 6
Electric signal parameter, amplitude, pulsewidth such as output voltage, the frequency of visual stimulus chip with extraneous light intensity susceptibility etc., and
And it is responsible for providing energy to entire vision prosthesis.The signal and energy of external controller are transmitted to body by Ligation in vitro cable
Outer transmitting antenna, external transmitting antenna are fixed on the epidermis outside eye socket bone by being implanted into subcutaneous magnet, wirelessly
Send control electric signal and energy.Receiver in body is implanted to retina inner membrance, is responsible for receiving control electric signal and energy, and lead to
It crosses internal connecting cable and is connected to photosensitive visual stimulus chip.
Visual stimulus chip includes 10~100000 light-operated electric pulse generators, each light-operated electric pulse generator packet
6a containing photodetector, Schmidt trigger, voltage controlled current source and stimulating electrode 6b.Visual stimulus chip is placed on photosensitive
The Intima area of the retina of cell dysfunction, photodetector array face incident light, stimulating electrode array is back to incidence
Light is simultaneously directly contacted with the optic nerve 7a of retina inner membrance.The Luminance Distribution of extraneous scene passes through the original optical system of eyes
Visual stimulus chip is reached across retina.Visual stimulus chip passes through photodetector, Schmidt trigger and voltage control
The Luminance Distribution image of extraneous scene is changed into the distribution map of the electrical impulse frequency compatible with nerve action potential by current source
Picture, the higher position of brightness, corresponding electrical impulse frequency are higher.Voltage amplitude, the arteries and veins of the output electric pulse of visual stimulus chip
Wide and output frequency is controlled with the susceptibility of light intensity by external controller.The output electric pulse of visual stimulus chip is directly made
The optic cell 7a in retina is used, even if the gangliocyte 7b of patient, amakrine 7c, Beale's ganglion cells 7d, water
Flat cell 7e, cone cell 7f, rod cell 7g and pigment epithelial cell 7h function are lost, this vision prosthesis remains to generate equivalent
Visual signal.
Visual stimulus chip, internal transmission cable are sealed by flexible, resistant material substrate, can be according to the shape of retina
Shape carries out bending extension.Control in vivo and functional unit are sealed by flexible and human body with bio-compatibility, resistant material,
Form the shape of similar capsule.Wherein visual stimulus chip is flexible, transparent by two panels, has bio-compatibility, corrosion resistant with human body
Corrosion material substrate 6c and 6d sealing, wherein photodetector, Schmidt trigger and the voltage controlled current source are located at lining
The inner surface of bottom 6c, substrate 6d punching, stimulating electrode array fill the hole array of substrate 6d, one end and Schmidt trigger array
Output end in contact, the other end and optic nerve 7a contact.
The functional layer of the light-operated electric pulse generator of each of visual stimulus chip can be silicon semiconductor and metal electrode, first
It makes on a silicon substrate, there is the nitrogen oxides of silicon between the silicon substrate and the functional layer of the light-operated electric pulse generator
Sacrificial layer as shifting process.
The functional layer of the optical detector of the light-operated electric pulse generator of each of visual stimulus chip can be GaAs base extension
Layer and metal electrode first make, the GaAs base epitaxial layer of the GaAs substrate and the optical detector on gaas substrates
Between have sacrificial layer of the AlAs shifting process.
The embodiment of the present invention propose retina inner membrance vision prosthesis, comprising external controller 1, Ligation in vitro cable 2,
External transmitting antenna 3, Receiver in body 4, internal connecting cable 5 and visual stimulus chip 6, visual stimulus chip are photosensitive core
Piece, is placed on retina inner membrance, and the electric signal of generation directly stimulates the optic nerve 7a of retina inner membrance.With directly parallel stimulation
Optic cell, without the conversion of additional electric signal, it is flexible extend, it is preferable etc. excellent with human eye original optical system compatibility
Point.
Fig. 2 is the light-operated electric pulse generator of each of visual stimulus chip of retina inner membrance of one embodiment of the invention
Principle electrical circuit figure；Each light-operated electric pulse unit include photodetector, Schmidt trigger, voltage controlled current source and
Stimulating electrode.The Schmidt trigger of light-operated electric pulse generator is formed by being no more than 6 field-effect tube, voltage controlled current source
It is formed by being no more than 2 field-effect tube.
Fig. 3 is the light-operated electric pulse generator of each of visual stimulus chip of retina inner membrance of one embodiment of the invention
A kind of possible MOS grades of circuit diagram.Wherein Schmidt trigger uses Q1,4 MOS systems of Q3 (PMOS) and Q2, Q4 (NOMS)
At feedback loop is made of 1 NMOS Q5.
Fig. 4 is that the light-operated electric pulse of each of visual stimulus chip of retina inner membrance of another embodiment of the present invention occurs
A kind of possible MOS grades of circuit diagram of device.Wherein Schmidt trigger uses Q1, Q2, Q3 (PMOS) and Q4, Q5, Q6 (NOMS) 6
A MOS is made, and feedback loop is made of 1 NMOS Q7.
In physical circuit, light-operated detector can be equivalent to a light-controlled current source, a junction capacity and an ohmic leakage.
Under original state, circuit output is low level, and optical detector is under the conditions of low-light, and light-controlled current source does not have substantially at this time
Electric current output, is in off state, and junction capacity both ends are stablized due to the charging of the controlled current source of feedback loop in high level shape
State, output is low level after Schmidt trigger is reversed.
When optical detector is by under light conditions, light-controlled current source begins with electric current output, and junction capacity is begun through at this time
Light-controlled current source is discharged over the ground, it should be noted that much smaller than charging current of this discharge current.Both end voltage starts slowly
It reduces, when both end voltage, which reduces, is more than Schmidt trigger turnover voltage, Schmidt trigger output is reversed, becomes high electricity
It is flat.Since the feedback loop of voltage controlled current source acts on, junction capacity charges rapidly at this time, and both ends are converted to high level, is more than
Schmidt trigger turnover voltage, leading to output is low level, replys original state.
As seen from the above analysis, which constitute an optically controlled oscillator, the pulse period of optically controlled oscillator output is taken
Certainly in the charge and discharge time of the junction capacity of optical detector, it is embodied in the photoelectric current size of optical detector and the electricity of feedback loop
Size is flowed, and pulse strength depends on the high level output value of Schmidt trigger.
For example, a kind of functional layer is entirely the production side of the light-operated electric pulse generator array of flexibility of silica-base material
Method:
First, photoelectricity is made on silicon (SOI) substrate on the insulating layer using the circuit of CMOS technology attached drawing to specifications
Detector, Schmidt trigger and feedback circuit unit form the functional layer of light-operated electric pulse clapp oscillator.
Second, photoetching adds plasma etching to add wet corrosion technique, below partial corrosion SOI substrate surface layer Si
SiO2, form the engraved structure below SOI substrate surface silicon.
Third, spin-on polyimide (PI) fill the hollow-out layer below SOI substrate surface silicon.
4th, photoetching adds plasma etching to add wet corrosion technique, corrodes below the Si of SOI substrate surface layer completely
SiO2。
5th, the surface silicon of SOI substrate and other films are transferred to by PI by dimethyl silicone polymer (PDMS) seal
On substrate.
6th, each discrete array unit is attached using extending curved snakelike conducting wire.
7th, other one layer of PI substrate is covered, the functional layer of light-operated electric pulse clapp oscillator is wrapped up.
8th, it is punched on PI substrate, exposes electrode, so that the subsequent cellula visualis on retina contact putting
Electricity.
For example, it is silica-base material that a kind of optical detector, which is GaAs sill, Schmidt trigger and feed circuit,
The production method of flexible light-operated electric pulse generator array:
First, epitaxial growth has the GaAs photodetector of AlAs sacrificial layer on gaas substrates.
Second, photoetching adds plasma etching to add wet corrosion technique, below partial corrosion GaAs photodetector
AlAs forms the engraved structure below GaAs photodetector.
Third, spin-on polyimide (PI) fill the hollow-out layer below GaAs photodetector.
4th, photoetching adds plasma etching to add wet corrosion technique, corrodes below GaAs photodetector completely
AlAs。
5th, by dimethyl silicone polymer (PDMS) seal by the GaAs photodetector and other films of GaAs substrate
It is transferred on PI substrate.
6th, using CMOS technology to specifications attached drawing circuit on the insulating layer on silicon (SOI) substrate production apply it is close
Special trigger and feedback circuit unit form the functional layer of light-operated electric pulse clapp oscillator.
7th, photoetching adds plasma etching to add wet corrosion technique, below partial corrosion SOI substrate surface layer Si
SiO2, form the engraved structure below SOI substrate surface silicon.
8th, spin-on polyimide (PI) fills the hollow-out layer below SOI substrate surface silicon.
9th, photoetching adds plasma etching to add wet corrosion technique, corrodes below the Si of SOI substrate surface layer completely
SiO2。
Tenth, the surface silicon of SOI substrate and other films are transferred to by PI by dimethyl silicone polymer (PDMS) seal
On substrate.
11st, each discrete array unit is attached using extending curved snakelike conducting wire.
12nd, other one layer of PI substrate is covered, the functional layer of light-operated electric pulse clapp oscillator is wrapped up.
13rd, it is punched on PI substrate, exposes electrode, so that the subsequent cellula visualis on retina contact putting
Electricity.
The vision prosthesis for the retina inner membrance that the embodiment of the present invention proposes includes external controller, Ligation in vitro cable, body
Outer transmitting antenna, Receiver in body, internal connecting cable and visual stimulus chip, visual stimulus chip are photosensor chip, are placed
In retina inner membrance, the electric signal of generation directly stimulates the optic cell of retina inner membrance.With directly parallel stimulation view mind
Through cell, without the conversion of additional electric signal, flexible the advantages that extending, is preferable with the original optical system compatibility of human eye.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indication or suggestion relative importance or implicitly indicates the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include at least one of the features.In the description of the present invention, " multiple "
It is meant that at least two, such as two, three etc., unless otherwise specifically defined.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or spy described in conjunction with this embodiment or example
Point is included at least one embodiment or example of the invention.In the present specification, schematic expression of the above terms are not
It must be directed to identical embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be in office
It can be combined in any suitable manner in one or more embodiment or examples.In addition, without conflicting with each other, the skill of this field
Art personnel can tie the feature of different embodiments or examples described in this specification and different embodiments or examples
It closes and combines.
Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example
Property, it is not considered as limiting the invention, those skilled in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modifies, replacement and variant.
Claims (6)
1. a kind of vision prosthesis of retina inner membrance, include external controller, Ligation in vitro cable, external transmitting antenna, in vivo
Receiver, internal connecting cable and visual stimulus chip, it is characterised in that: the visual stimulus chip is photosensor chip, is placed
In the position of retina inner membrance, the electric signal of generation directly stimulates the optic cell of retina inner membrance；
The light-operated electric pulse generator of each of the visual stimulus chip includes:
Incident optical signal is converted voltage signal by photodetector, and incident light is stronger, the output voltage of the photodetector
Change faster；
Schmidt trigger is exported corresponding trigger voltage and is made using the output voltage of the photodetector as input voltage
For the output of the light-operated electric pulse generator；
Voltage controlled current source carries out charge and discharge to the photodetector both ends according to the output voltage of the Schmidt trigger
Electricity realizes the feedback control to the output voltage of the photodetector；
Stimulating electrode, one end connect the output end of the Schmidt trigger, and the other end directly contacts the view mind of retina inner membrance
Through cell；
The Schmidt trigger of the light-operated electric pulse generator of each of the visual stimulus chip is by being no more than 6 field-effect tube groups
At voltage controlled current source is formed by being no more than 2 field-effect tube, and feedback loop is made of 1 NMOS；
Photodetector, Schmidt trigger and the voltage control of the light-operated electric pulse generator of each of the visual stimulus chip
The functional layer of current source is inorganic semiconductor and metal material, is transferred to flexible substrate after the production of inorganic semiconductor substrate
On.
2. the vision prosthesis of retina inner membrance according to claim 1, it is characterised in that: the visual stimulus chip is packet
Two-dimensional array device containing multiple light-operated electric pulse generators, wherein each light-operated electric pulse generator is according to incident light
The electric impulse signal compatible with optic nerve is generated, the light for being irradiated to the light-operated electric pulse generator is stronger, the electricity of generation
The frequency of pulse signal is higher.
3. the vision prosthesis of described in any item retina inner membrances according to claim 1~2, it is characterised in that: the vision thorn
Swash chip, internal connecting cable, internal controller to be sealed by flexible, resistant material substrate, the shape of the visual stimulus chip
Shape can carry out bending extension according to the shape of retina, and the internal controller is sealed by flexible, resistant material, form glue
The shape of capsule.
4. the vision prosthesis of retina inner membrance according to claim 1, it is characterised in that: the visual stimulus chip is by two
Piece is flexible, transparent, resistant material substrate seals, wherein the photodetector, Schmidt trigger and voltage control electric current
Source is located therein the inner surface of a piece of substrate, another substrate punching, and the stimulating electrode array fills another substrate
Hole array, the output end in contact of stimulating electrode one end and Schmidt trigger array, the stimulating electrode other end and optic nerve connect
Touching.
5. the vision prosthesis of retina inner membrance according to claim 1, it is characterised in that: the visual stimulus chip it is every
The functional layer of a light-operated electric pulse generator is silicon semiconductor and metal electrode, is made on a silicon substrate, the silicon substrate and institute
State the sacrificial layer for having the nitrogen oxides of silicon as shifting process between the functional layer of light-operated electric pulse generator.
6. the vision prosthesis of retina inner membrance according to claim 1, it is characterised in that: the visual stimulus chip it is every
The functional layer of the optical detector of a light-operated electric pulse generator is GaAs base epitaxial layer and metal electrode, is made on gaas substrates
Make, has sacrificial layer of the AlAs shifting process between the GaAs substrate and the GaAs base epitaxial layer of the photodetector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610537333.7A CN105997342B (en) | 2016-07-08 | 2016-07-08 | A kind of vision prosthesis of retina inner membrance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610537333.7A CN105997342B (en) | 2016-07-08 | 2016-07-08 | A kind of vision prosthesis of retina inner membrance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105997342A CN105997342A (en) | 2016-10-12 |
| CN105997342B true CN105997342B (en) | 2018-12-11 |
Family
ID=57108977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610537333.7A Active CN105997342B (en) | 2016-07-08 | 2016-07-08 | A kind of vision prosthesis of retina inner membrance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105997342B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107029350B (en) * | 2017-03-15 | 2020-06-19 | 清华大学 | Micro-needle array electrode for optic nerve prosthesis |
| CN111182863B (en) * | 2017-07-18 | 2022-01-04 | 辛特科技有限公司 | System for acquiring and processing artificial eye image |
| WO2019014849A1 (en) * | 2017-07-18 | 2019-01-24 | 辛特科技有限公司 | Method for collecting and processing artificial eye image |
| CN112206414A (en) * | 2020-08-25 | 2021-01-12 | 浙江大学 | Retina prosthesis and processing method thereof |
| CN114917471A (en) * | 2022-01-21 | 2022-08-19 | 武汉衷华脑机融合科技发展有限公司 | Neural interface system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1438906A (en) * | 2000-05-04 | 2003-08-27 | 奥普托拜奥尼克斯公司 | Improved artificial retina therapeutic equipment and method of attachment |
| CN1806865A (en) * | 2005-12-17 | 2006-07-26 | 重庆大学 | Retina electrostimulation pixel circuit for artificial vision rehabilitation |
| CN101590305A (en) * | 2009-06-18 | 2009-12-02 | 重庆大学 | Be used for the artificial retina electrostimulation pixel circuit that visual performance is repaired |
| CN103179928A (en) * | 2010-06-28 | 2013-06-26 | 贾瓦哈拉尓尼赫鲁高级科学研究中心 | Artificial retina device |
| CN104873330A (en) * | 2015-06-19 | 2015-09-02 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina implant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8150526B2 (en) * | 2009-02-09 | 2012-04-03 | Nano-Retina, Inc. | Retinal prosthesis |
| US8442641B2 (en) * | 2010-08-06 | 2013-05-14 | Nano-Retina, Inc. | Retinal prosthesis techniques |
-
2016
- 2016-07-08 CN CN201610537333.7A patent/CN105997342B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1438906A (en) * | 2000-05-04 | 2003-08-27 | 奥普托拜奥尼克斯公司 | Improved artificial retina therapeutic equipment and method of attachment |
| CN1806865A (en) * | 2005-12-17 | 2006-07-26 | 重庆大学 | Retina electrostimulation pixel circuit for artificial vision rehabilitation |
| CN101590305A (en) * | 2009-06-18 | 2009-12-02 | 重庆大学 | Be used for the artificial retina electrostimulation pixel circuit that visual performance is repaired |
| CN103179928A (en) * | 2010-06-28 | 2013-06-26 | 贾瓦哈拉尓尼赫鲁高级科学研究中心 | Artificial retina device |
| CN104873330A (en) * | 2015-06-19 | 2015-09-02 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina implant |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105997342A (en) | 2016-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105997342B (en) | A kind of vision prosthesis of retina inner membrance | |
| US8180453B2 (en) | Electrode array for neural stimulation | |
| US7257446B2 (en) | Package for an implantable medical device | |
| US6393327B1 (en) | Microelectronic stimulator array | |
| US20020111655A1 (en) | Permanent retinal implant device | |
| US20020161417A1 (en) | Microelectronic stimulator array for stimulating nerve tissue | |
| KR101979994B1 (en) | Epiretinal prosthetic device and system simulating the physiological mechanism of retinal cells | |
| TW201701905A (en) | Artificial retinal prosthesis system, optical device and retina chip | |
| KR102196461B1 (en) | Epiretinal artificial retinal device | |
| EP1762269A2 (en) | Visual prothesis | |
| AU2004235627B2 (en) | Retinal color prosthesis for color sight restoration | |
| AU2006202503B2 (en) | Retinal color prosthesis for color sight restoration | |
| JP2008212234A (en) | Vision recovery assisting apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |