CN105943915A - Traditional Chinese medicine for treating fluid retention invading heart type arrhythmia and preparation method - Google Patents
Traditional Chinese medicine for treating fluid retention invading heart type arrhythmia and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating fluid retention invading heart type arrhythmia and a preparation method. The traditional Chinese medicine comprises the following raw medicinal materials: purpleflower holly fruit, gymnadenia conopsea, herba portulacae, lobelia chinensis, salsola collina, galium verum, croton crassifolius, siberian filifolium herb, broadleaf holly leaf, roseapple peel, herb of ashycoloured ironweed, equisetum arvense, valeriana jatamansi, schizocapsa plantaginea hance, herb of comnon thunia, herb of wilson passionflower, root or fruit of fourpetal rose, corn, Chinese pholidota herb and peperomia blanda. The traditional Chinese medicine has the following beneficial effects: the traditional Chinese medicine can be combined with conventional western medicine to treat the fluid retention invading heart type arrhythmia, realizes a better treatment effect, and avoids toxic and side effects and adverse reaction while the disease does not relapse easily after healing.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly relate to one treat diseases caused by retention of fluid insult cardioid ARR in
Medicine and preparation method.
Background technology
Arrhythmia is changing of the heart beat rhythm caused by the origin of heartbeat or conduction abnormalities or frequency
Become, be one of clinical modal Cardiovasculai appearance in patient.The clinical features of patients with arrhythmia differs,
The lighter occasionally can be found without any discomfort in time having a medical check-up, and serious can jeopardize patient vitals.Patient is normal
Be presented with having palpitation, breathe hard, uncomfortable in chest, dizziness headache, tinnitus, the symptom such as forgetful, weak.
Arrhythmia is the most relatively conventional disease, doctor trained in Western medicine typically arrhythmia is divided into Quick-type and
Slowly two kinds of type.Most of antiarrhythmic Western medicine medicines are to act on tachyarrhythmia, slowly
The ARR medicine of type then seems the most single, and most of antiarrhythmic drug inherently may be used
Drug resistance, the rhythm of the heart can be caused partially slow and there is ARR risk, unsustainable taking;And implant people
Work pacemaker is treated, expensive, and not all patient can undertake.Therefore, explore other approach to control
Treat arrhythmia and seem significant.
The traditional Chinese medical science has long history, have accumulated abundant diagnosis and treatment experience over the past thousands of years, compared with doctor trained in Western medicine,
Numerous disease is had novel viewpoint, unique treatment method and definite curative effect.The traditional Chinese medical science focuses on organic conception,
Mutual relation between paying special attention to according to internal organs during diagnosis and treatment, the comprehensive function balance analyzing each internal organs of human body,
Carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, then same disease the most usually uses typing distinguish the method controlled such that it is able to more
Good carries out symptomatic treatment for disease, it is thus achieved that good effect.
Summary of the invention
The technical problem to be solved is, it is provided that one is used for treating diseases caused by retention of fluid and insults the mistake of the cardioid rhythm of the heart
Normal Chinese medicine and preparation method, this Chinese medicine is relieving convulsion sedate, tranquilizing by nourishing the heart, treatment diseases caused by retention of fluid icepro cardioid rhythm of the heart mistake
Often have rapid-action, determined curative effect, safety is high, have no side effect and be difficult to the advantage of recurrence.
In order to solve above-mentioned technical problem, the invention provides one treat diseases caused by retention of fluid insult cardioid ARR
Chinese medicine, Chinese medicine includes following raw medicinal material: Fructus Ilicis Purpureae, Rhizoma Gymnadeniae, Herba Portulacae, Herba Lobeliae Chinensis, Herba Salsolae Collinae,
Herba galii veri, Radix Crotonis Crassifolii, rabbit hair Artemisia, Folium Ilicis, Pericarpium syzygii, Herba Vernoniae Cinereae, Herba Equiseti Arvinsis, Rhizoma valerianae latifoliae, paddy field
Seven, Herba Thuniae Albae, Herba Passiflorae Wilsonii, Radix seu Fructus Rosae Sericeae, Semen setariae, Pseudobulbus Pholidotae Chinensis and Herba Peperomiae Dindygulensis.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Ilicis Purpureae 10~20
Part, Rhizoma Gymnadeniae 25~35 parts, Herba Portulacae 15~25 parts, Herba Lobeliae Chinensis 20~30 parts, Herba Salsolae Collinae 10~
20 parts, Herba galii veri 13~23 parts, Radix Crotonis Crassifolii 6~16 parts, rabbit hair Artemisia 20~30 parts, Folium Ilicis 10~
20 parts, Pericarpium syzygii 25~35 parts, Herba Vernoniae Cinereae 12~22 parts, Herba Equiseti Arvinsis 20~30 parts, Rhizoma valerianae latifoliae 10~
20 parts, Rhizoma Schizocapsae Plantagineae 5~15 parts, Herba Thuniae Albae 10~20 parts, Herba Passiflorae Wilsonii 10~20 parts, Radix seu Fructus Rosae Sericeae 22~32
Part, Semen setariae 16~26 parts, Pseudobulbus Pholidotae Chinensis 25~35 parts and Herba Peperomiae Dindygulensis 10~20 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Ilicis Purpureae 12~
17 parts, Rhizoma Gymnadeniae 28~33 parts, Herba Portulacae 17~22 parts, Herba Lobeliae Chinensis 20~25 parts, Herba Salsolae Collinae 13~
18 parts, Herba galii veri 15~20 parts, Radix Crotonis Crassifolii 8~13 parts, rabbit hair Artemisia 22~27 parts, Folium Ilicis 10~
15 parts, Pericarpium syzygii 27~32 parts, Herba Vernoniae Cinereae 14~19 parts, Herba Equiseti Arvinsis 20~25 parts, Rhizoma valerianae latifoliae 13~
18 parts, Rhizoma Schizocapsae Plantagineae 6~11 parts, Herba Thuniae Albae 12~17 parts, Herba Passiflorae Wilsonii 13~18 parts, Radix seu Fructus Rosae Sericeae 26~31
Part, Semen setariae 18~23 parts, Pseudobulbus Pholidotae Chinensis 27~32 parts and Herba Peperomiae Dindygulensis 15~20 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Ilicis Purpureae 13
Part, Rhizoma Gymnadeniae 32 parts, Herba Portulacae 18 parts, Herba Lobeliae Chinensis 24 parts, Herba Salsolae Collinae 16 parts, Herba galii veri 17
Part, Radix Crotonis Crassifolii 12 parts, rabbit hair Artemisia 24 parts, Folium Ilicis 15 parts, Pericarpium syzygii 28 parts, Herba Vernoniae Cinereae 18
Part, Herba Equiseti Arvinsis 22 parts, Rhizoma valerianae latifoliae 17 parts, Rhizoma Schizocapsae Plantagineae 7 parts, Herba Thuniae Albae 15 parts, Herba Passiflorae Wilsonii 17 parts, mountain
Fructus Rosae Normalis 30 parts, Semen setariae 20 parts, Pseudobulbus Pholidotae Chinensis 30 parts and Herba Peperomiae Dindygulensis 16 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Ilicis Purpureae 16
Part, Rhizoma Gymnadeniae 29 parts, Herba Portulacae 22 parts, Herba Lobeliae Chinensis 21 parts, Herba Salsolae Collinae 14 parts, Herba galii veri 20
Part, Radix Crotonis Crassifolii 8 parts, rabbit hair Artemisia 26 parts, Folium Ilicis 10 parts, Pericarpium syzygii 30 parts, Herba Vernoniae Cinereae 15 parts,
Herba Equiseti Arvinsis 25 parts, Rhizoma valerianae latifoliae 15 parts, Rhizoma Schizocapsae Plantagineae 10 parts, Herba Thuniae Albae 12 parts, Herba Passiflorae Wilsonii 14 parts, Radix seu Fructus Rosae Sericeae
28 parts, Semen setariae 22 parts, Pseudobulbus Pholidotae Chinensis 28 parts and Herba Peperomiae Dindygulensis 18 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2~
The determining alcohol of 4 times is the ethanol of 85~95%, is heated to reflux 1~3 hour, extracts, and filters acquisition first
Extracting solution;Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1~2 times be 85~
The ethanol of 95%, is heated to reflux 1~3 hour, extracts, and filters and obtains the second extracting solution;Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders obtained by second step, add relative to its quality 0.1~0.3 times is micro-
Crystalline cellulose, 0.05~0.15 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletizes,
It is dried, adds relative to micropowders quality 0.005~0.05 times of magnesium stearate, granulate, tabletting, system
Become.
Wherein, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4~the alcohol of 8 times
Concentration is the ethanol of 85%~95%, is heated to boiling reflux 3~5 hours, filters, use percolation with
The speed slowly percolation of per minute 1~2ml, collects percolate, subsequently in vacuum 0.06~0.09Mpa
Under to be evaporated to relative density when 50~60 DEG C be the mastic of 1.04~1.10, be spray-dried, spraying
The inlet temperature 160 of drying machine~175 DEG C, leaving air temp 80~85 DEG C, be ground into powder subsequently, make
Dried cream powder;
Step 2: add relative to dried cream powder quality 0.2~the cane sugar powder of 0.4 times in the dried cream powder obtained
With the dextrin of 0.1~0.2 times, make granule, be dried in 40~50 DEG C, it is thus achieved that granule.
Beneficial effects of the present invention: the Chinese medicine of the present invention, it is possible to associating conventional western medicine treatment diseases caused by retention of fluid insults cardioid
Arrhythmia, therapeutic effect is more preferable, has no side effect and untoward reaction, difficulty in relapse after healing.
Detailed description of the invention
The invention provides one and treat the diseases caused by retention of fluid icepro ARR Chinese medicine of cardioid, wherein, including following former
Material medical material: Fructus Ilicis Purpureae, Rhizoma Gymnadeniae, Herba Portulacae, Herba Lobeliae Chinensis, Herba Salsolae Collinae, Herba galii veri, Radix Crotonis Crassifolii, rabbit
Hair Artemisia, Folium Ilicis, Pericarpium syzygii, Herba Vernoniae Cinereae, Herba Equiseti Arvinsis, Rhizoma valerianae latifoliae, Rhizoma Schizocapsae Plantagineae, Herba Thuniae Albae, Herba Passiflorae Wilsonii,
Radix seu Fructus Rosae Sericeae, Semen setariae, Pseudobulbus Pholidotae Chinensis and Herba Peperomiae Dindygulensis.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Fructus Ilicis Purpureae: [another name] Ilicis Purpureae is real, freeze blue or green tree.[source] medical material Ji Yuan: plant for Aquifoliaceae
The fruit of thing Ilicis Purpureae.[nature and flavor] are sweet;Bitter;Cool.[return through] liver;Kidney channel.[function cures mainly] mends
Liver and kidney;Curing rheumatism;Arresting bleeding and healing up ulcer.Main early whitening of beard and hair;Wind shows arthralgia pain;Digestive ulcerative bleeding;Hemorrhoid;
Ulcer being unable to heal.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Gymnadeniae: [another name] hides Radix Notoginseng, Fructus Citri Sarcodactylis ginseng, blue, palm ginseng, hands ginseng, negative and positive ginseng.[come
Source] medical material Ji Yuan: for orchid Rhizoma Gymnadeniae or the tuber of gymnadenia crassinervis Finet.[nature and flavor] are sweet;Flat.[return
Warp] lung;Spleen;Stomach warp.[function cures mainly] relieving cough and asthma;Yishen Jianpi;Regulate the flow of vital energy and blood;Pain relieving.
Main cough and asthma due to lung deficiency;Asthenia is become thin;Neurasthenia;Suffer from a deficiency of the kidney lassitude loin and legs;Sexual impotence;Spermatorrhea;Frequent micturition;Slowly
Property hepatitis;Chronic diarrhea;Lose blood;Leukorrhagia;Breast is few;Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Portulacae: [another name] HERBA PORTULACAE, horse Herba Amaranthi tricoloris, Dens Equi dish, purslane and hairyvein agrimonia, five Medulla Tetrapanacis, long life dish,
Herba Peristrophes, ash Herba Amaranthi tricoloris, horse step on dish, beans lobe dish careless, peaceful and comfortable, acid Herba Amaranthi tricoloris, bean plate dish, Semen Benincasae dish, length
Life Herba Amaranthi tricoloris, beans lobe bean grass, Magnoliacoco, tart flavour dish, pig mother's dish, lion be careless, Ma Lai, horse Serpentis dish, ant
Ant dish, longevity greens/mustard green, resistance to Indian Rorippa Herb.[source] medical material Ji Yuan: for the herb of portulacaceous plant Herba Portulacae.
[nature and flavor] acid;Cold in nature.[return through] large intestine;Liver Channel.[function cures mainly] heat-clearing and toxic substances removing;Removing heat from blood is only
Dysentery;Dehumidify treating stranguria.Main pyretic toxicity dysentery;Pyretic stranguria;Urine retention;Leucorrhea with red and white discharge;Metrorrhagia;Hemorrhoidal bleeding;Skin infection carbuncle
Furuncle;Erysipelas;Scrofula;Exudative dermatitis;The baldst.[extracts] " China's book on Chinese herbal medicine "
Herba Lobeliae Chinensis: [another name] anxious solve rope, Chinese Lobelia, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, fish tail flower, half of chrysanthemum,
Herba Pteridis Semipinnatae, milk grass, half of flower, arrow bean grass, with the wind flag, monolithic bud, little Flos Nelumbinis beeweed careless, continuous,
Blow blood grass, Herba veronicastri villosuli, infantile malnutrition grass, white wax grass skating, golden aster grass, golden pheasant tongue, film clips lotus, Pian Lian, melon
Core grass, Serpentis peck Cordyceps careless, long.[source] medical material Ji Yuan: the band root for Campanulaceae Herba Lobeliae Chinensis is complete
Grass.[nature and flavor] sweet in the mouth;Property flat.[return through] GUIXIN;Lung;Small intestine meridian.[function cures mainly] heat clearing away
Removing toxic substances;Inducing diuresis to remove edema.Main venom;Carbuncle furuncle;Tonsillitis;Warm rash;Tinea pedis;Traumatic injury damages
Wound;Jaundice due to damp-heat;Appendicitis;Enteritis;Nephritis;Cirrhotic ascites and kinds cancer.[extracts] " in
China's book on Chinese herbal medicine "
Herba Salsolae Collinae: [another name] prick fluffy, sting fluffy, bright of trident, Pilus Sus domestica tassel, pitch bright, monkey hair,
Herba galii veri, the most fluffy stalk.[source] medical material Ji Yuan: for the herb of chenopod Herba Salsolae Collinae.[nature and flavor]
Light;Cool in nature.[return through] Liver Channel.[function cures mainly] suppressing the hyperactive liver and subsiding YANG;Loosening bowel to relieve constipation.Main hypertension;
The most sick;Dizziness;Insomnia;Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "
Herba galii veri: [another name] cattle clothing, ferrum chi grass, menstruation grass, Semen setariae flower, willow husband floss Artemisia, furunculosis
Artemisia, eritrichium pedumculare, La Mahuang, the white Radix Rubiae of soil Seedling grass.[source] medical material Ji Yuan: fluffy for Maguireothamnus speciosus
The herb of sub-dish.[nature and flavor] are micro-pungent;Bitter;It is slightly cold.[function cures mainly] heat-clearing and toxic substances removing;Promoting blood circulation to restore menstrual flow;
Dispelling wind for relieving itching.Main hepatitis;Ascites;Laryngopharynx swelling and pain;Furuncle toxic swelling;Traumatic injury;Women's amenorrhea;Band
Under;Venom;Honor measles;Paddy field dermatitis.[extracts] " China's book on Chinese herbal medicine "
Radix Crotonis Crassifolii: [another name] Radix Sophorae Tonkinensis, wood Lignum Aquilariae Resinatum, Aquilaria sinensis (Lour.) Spreng., refute atrophic debility of bones, rolling Pheretima, cattle fragrant,
Chicken foot perfume, short-foot pig, rolling Pheretima, saturating Pheretima, Clausena excavata Burm.f., Jin Jinfeng.[source] medical material Ji Yuan:
Root for euphorbia plant Radix Crotonis Crassifolii.[nature and flavor] mildly bitter flavor;Pungent;Warm in nature;Mild toxicity.[return through] heart;
Lung;Liver;Stomach;Kidney channel.[function cures mainly] regulating QI to relieve pain;Expelling wind and removing dampness;Reducing swelling and alleviating pain.Main gastral cavity abdomen
Distending pain;Rheumatic arthralgia;Colic;Dysmenorrhea;Laryngopharynx swelling and pain and treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Rabbit hair Artemisia: [another name] Tanacetum sibiricum L., Herba Violae dissectae, frightened grass, JINGCAO.[source] medical material Ji Yuan:
Herb for feverfew Filifolium sibiricum (Linn.) Kitam..[nature and flavor] bitter in the mouth;Cold in nature.[function cures mainly] heat-clearing and toxic substances removing;
Calm the nerves;Regulating menstruation.Main high heat;Cardiopalmus;Insomnia;Menoxenia;Carbuncle skin infection.[extracts] " China
Book on Chinese herbal medicine "
Folium Ilicis: [another name] hair leaf cattle berry wooden, yellow, soil tea, Cha Gai, Fructus Gleditsia acupuncture tea.[source]
Medical material Ji Yuan: for the tender leaf of holly plant Ilex cornuta Lindl., Cortex Ilicis Rotundae or Ilex kudincha C. J. Tseng.[nature and flavor] are sweet;
Bitter;Cold.[return through] liver;Lung;Stomach.[function cures mainly] wind and heat dispersing;Improving eyesight is promoted the production of body fluid.Main air heat
Headache;Toothache;Conjunctival congestion;Ear;Aphtha;Calentura excessive thirst;Have loose bowels;Dysentery.[extracts] " China
Book on Chinese herbal medicine "
Pericarpium syzygii: [source] medical material Ji Yuan: the dry peel chosen for ma Tiao Jin section plant Pu.[nature and flavor]
Sweet in the mouth;Micro-acid;Warm in nature.[return through] returns spleen;Lung meridian.[function cures mainly] warming the stomach spleen invigorating;Warming the lung is only
Cough;Removing blood stasis is subsided a swelling.Main cold syndrome of the stomach singultus;Diarrhea due to hypofunction of the spleen;Chronic dysentery;Deficiency of the lung cough of cold type;Cellulitis tumor.[extracts]
" China's book on Chinese herbal medicine "
Herba Vernoniae Cinereae: [another name] ipomoea bonanox, star wipe grass, post color grass, perfume (or spice) of returning from the grave, XIAOSHANHU, false salty shrimp,
Branch Rhizoma et radix valerianae, Flos Carthami Herba Veronicae, four eyed grass, the red grass in sky, cane ginseng.[source] medical material Ji Yuan: for chrysanthemum
The herb of section plant Herba Vernoniae Cinereae or root.[nature and flavor] bitter in the mouth;Pungent;Cool in nature.[function cures mainly] dispelling wind is clear
Heat;Dehumidifying;Removing toxic substances.Main sense heating;Cough;Acute icterohepatitis;Damp-heat diarrhea;The most stagnant;Parent
Pyogenic infections from tumour or sore;Mastitis;Rhinitis;Venom.[extracts] " China's book on Chinese herbal medicine "
Herba Equiseti Arvinsis: [another name] continue grass, male and female grass, hug JIECAO, KONGXINCAO, hornet grass, Herba Adianti,
Yellow ant grass, Herba Clinopodii Polycephali, Rhizoma seu Herba Elatostematis stewardii, very little aunt grass, nib grass, Herba Eguiseti Debilis.[source] medical material Ji Yuan:
Herb for Equisetaceae plant Herba Equiseti Arvinsis.[nature and flavor] are bitter;Cool;Nontoxic;Flat.[return through] lung;Stomach;
Liver Channel.[function cures mainly] stops blooding;Diuresis;Improving eyesight.Main haematemesis;Spitting of blood;Have blood in stool;Metrorrhagia;Epistaxis;
Traumatic hemorrhage;Conjunctivitis;Gonorrhea.[extracts] " China's book on Chinese herbal medicine "
Rhizoma valerianae latifoliae: [another name] Herba Asari, Devil Frown, Semen Sojae Preparatum dish root, nine turns of perfume (or spice), Herba clintoniae udensis, ponies
Hoof Canis familiaris L. medicine fragrant, smelly, mill pin are spent, connect Rhizoma et radix valerianae, Rhizoma et radix valerianae, lotus of nourishing blood, smelly medicine, Wu Can, are rescued greatly.
[source] medical material Ji Yuan: for the rhizome of Valerianaceae plant Rhizoma valerianae latifoliae.[nature and flavor] acrid in the mouth;Micro-hardship;Property
Temperature.[function cures mainly] regulate the flow of vital energy and in, dispelling cold and removing dampness;Promoting blood circulation and detumescence.Main abdominal distention;Tell and have loose bowels;
Infantile malnutrition;Anemofrigid-damp arthralgia;Limb air water swells;Menoxenia;Traumatic injury;Furuncle.[extracts] " in
China's book on Chinese herbal medicine "
Rhizoma Schizocapsae Plantagineae: [another name] Rhizoma Schizocapsae Plantagineae, Herba Senecionis Chrysanthemoidis, Semen Capparis, water bird head, water bird head chicken young, whole,
Water shrimp public affairs, Radix et Rhizoma Rhei Franzenbachii, Cipangopaludina chinensis seven, horse old man, little Cipangopaludina chinensis seven, water dog son, water Semen Arecae.[source]
Medical material Ji Yuan: for the tuber of potato section plant dehiscent fruit potato.[nature and flavor] are sweet;Bitter;Cool;Slightly poisonous.
[function cures mainly] heat-clearing and toxic substances removing;Eliminating phlegm and stopping cough;Regulate the flow of vital energy only production capacity;Dissipating blood stasis stops blooding.Main cold, fever;
Phlegm-heat cough;Pertussis;Abdominal distention;Dysentery is suffered from abdominal pain;Dyspepsia;Infantile malnutrition;Hepatitis;Pharynx
Larynx swells and ache;Toothache;Mumps;Scrofula;Skin ulcer swells;Scald, burn;Herpes zoster;Traumatic injury;Wound
Hemorrhage.[take passages " China's book on Chinese herbal medicine "
Herba Thuniae Albae: [another name] oecoeclades falcata, thrum, Dianthus chinensis, Cortex torricelliae tiliifoliae, logical orchid, stalagmite, rock bamboo.[come
Source] medical material Ji Yuan: for the herb that orchid Radix Crotalariae szemoensis are blue.[nature and flavor] are sweet;Flat.[return through] lung;Stomach;
Kidney channel.[function cures mainly] relieving cough and asthma;Blood circulation promoting and blood stasis dispelling;Synthetism.Main dyspnea and cough due to lung-heat;Gastric abscess;Fall
Play damage;Fracture.[extracts] " China's book on Chinese herbal medicine "
Herba Passiflorae Wilsonii: [another name] slice leaf, Oxyria sinensis Hemsl., half-section leaf, half-section kwan-yin, shovel leaf Herba Passiflorae Caeruleae.
[source] medical material Ji Yuan: for the herb of Passifloraceae plant Passiflora wilsonii.[nature and flavor] mildly bitter flavor;
Warm in nature.[function cures mainly] wind-damp dispelling;Invigorating the liver and kidney;Promoting blood flow to regulate menstruation, parasite killing preventing the attack (or recurrence) of malaria.The sliding pain of main air temperature;
Sore waist and aching in the waist and the back;Hepatitis;Liver cirrhosis;Menoxenia;Traumatic injury;Fracture;Malaria;Ascariasis.[pluck
Record] " China's book on Chinese herbal medicine "
Radix seu Fructus Rosae Sericeae: [source] medical material Ji Yuan: for root and the fruit of rosaceous plant thin,tough silk hair Flos Rosae Multiflorae.[property
Taste] sweet, sour, puckery;Flat.[return through] spleen;Large intestine channel.[function cures mainly] spleen invigorating helps fortune, dysentery relieving.
Main food stagnation abdominal distention;Borborygmus are suffered from diarrhoea.[extracts] " China's book on Chinese herbal medicine "
Semen setariae: [another name] white fine strain of millet foxtail millet, sacrifical grain in ancient times rice, foxtail millet paddy, Semen setariae, hard foxtail millet, Xian foxtail millet, millet, cold foxtail millet,
Huang Su, Semen setariae.[source] medical material Ji Yuan: for grass fine strain of millet or the kernel of foxtail millet.[nature and flavor] taste
Sweet;Salty;Cool in nature.[return through] kidney;Spleen;Stomach warp.[function cures mainly] and middle kidney tonifying;Heat extraction;Solve
Poison.Main taste deficiency-heat;Regurgitation is vomitted;Abdominal distention lack of appetite;Quench one's thirst;Dysentery;Burn and scald.[extracts] " in
China's book on Chinese herbal medicine "
Pseudobulbus Pholidotae Chinensis: [another name] tor lotus, stone Fructus Canarii albi, Herba Bulbophylli Odoratissim, thousand short, Herba Bulbophylli inconspicui, little clasp blue,
Big bracketplant, Pumex dry measure used in former times, upper Pseudobulbus Pholidotae Chinensis, Pseudobulbus Pholidotae Chinensis grass, Ma Liugen, upper Bulbus Lycoridis Radiatae, Herba Bulbophylli inconspicui orchid, stone Fructus Corni,
Didactic literary composition orchid, the Oviductus Ranae that climbs the tree, Ishikawa dish.[source] medical material Ji Yuan: for the pseudobulb of orchid Pseudobulbus Pholidotae Chinensis
Or herb.[nature and flavor] are sweet;Micro-hardship;Cool in nature.[return through] lung;Kidney channel.[function cures mainly] yin nourishing
Lung moistening;Heat-clearing and toxic substances removing;Dampness removing;Repercussive.Main cough due to lung-heat;Hemoptysis;Spit blood;Dizziness;Headache;Dream
Lose;Laryngopharynx swelling and pain;Rheumatalgia;Damp and hot edema;Dysentery;Leucorrhea;Infantile malnutrition;Scrofula;Traumatic injury.
[extracts] " China's book on Chinese herbal medicine "
Herba Peperomiae Dindygulensis: [another name] burn leaf, peppergrass, stone Semen Benincasae, SANYE are harvested, Radix Ardisiae Punctatae, Shi Macai,
Herba Seu Radix Peperomiae Tetraphyllae, scattered blood gallbladder, Semen Phaseoli lobe, Semen Sojae Preparatum seven.[source medical material Ji Yuan: for Piperaceae plant Herba Peperomiae Dindygulensis
Herb.[nature and flavor] are pungent;Cool.[return through] lung;Spleen;Liver;Kidney channel.[function cures mainly] heat clearing away
Removing toxic substances;Blood stasis-eliminating and stagnation-dissipating;Inducing diuresis to remove edema.Main lung-heat cough with asthma;Measles;Sore;Cancerous protuberance;Burn and scald;Fall
Play damage;Oedema due to nephritis.[extracts] " China's book on Chinese herbal medicine "
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Ilicis Purpureae 10~20
Part, Rhizoma Gymnadeniae 25~35 parts, Herba Portulacae 15~25 parts, Herba Lobeliae Chinensis 20~30 parts, Herba Salsolae Collinae 10~
20 parts, Herba galii veri 13~23 parts, Radix Crotonis Crassifolii 6~16 parts, rabbit hair Artemisia 20~30 parts, Folium Ilicis 10~
20 parts, Pericarpium syzygii 25~35 parts, Herba Vernoniae Cinereae 12~22 parts, Herba Equiseti Arvinsis 20~30 parts, Rhizoma valerianae latifoliae 10~
20 parts, Rhizoma Schizocapsae Plantagineae 5~15 parts, Herba Thuniae Albae 10~20 parts, Herba Passiflorae Wilsonii 10~20 parts, Radix seu Fructus Rosae Sericeae 22~32
Part, Semen setariae 16~26 parts, Pseudobulbus Pholidotae Chinensis 25~35 parts and Herba Peperomiae Dindygulensis 10~20 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Ilicis Purpureae 12~
17 parts, Rhizoma Gymnadeniae 28~33 parts, Herba Portulacae 17~22 parts, Herba Lobeliae Chinensis 20~25 parts, Herba Salsolae Collinae 13~
18 parts, Herba galii veri 15~20 parts, Radix Crotonis Crassifolii 8~13 parts, rabbit hair Artemisia 22~27 parts, Folium Ilicis 10~
15 parts, Pericarpium syzygii 27~32 parts, Herba Vernoniae Cinereae 14~19 parts, Herba Equiseti Arvinsis 20~25 parts, Rhizoma valerianae latifoliae 13~
18 parts, Rhizoma Schizocapsae Plantagineae 6~11 parts, Herba Thuniae Albae 12~17 parts, Herba Passiflorae Wilsonii 13~18 parts, Radix seu Fructus Rosae Sericeae 26~31
Part, Semen setariae 18~23 parts, Pseudobulbus Pholidotae Chinensis 27~32 parts and Herba Peperomiae Dindygulensis 15~20 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Ilicis Purpureae 13
Part, Rhizoma Gymnadeniae 32 parts, Herba Portulacae 18 parts, Herba Lobeliae Chinensis 24 parts, Herba Salsolae Collinae 16 parts, Herba galii veri 17
Part, Radix Crotonis Crassifolii 12 parts, rabbit hair Artemisia 24 parts, Folium Ilicis 15 parts, Pericarpium syzygii 28 parts, Herba Vernoniae Cinereae 18
Part, Herba Equiseti Arvinsis 22 parts, Rhizoma valerianae latifoliae 17 parts, Rhizoma Schizocapsae Plantagineae 7 parts, Herba Thuniae Albae 15 parts, Herba Passiflorae Wilsonii 17 parts, mountain
Fructus Rosae Normalis 30 parts, Semen setariae 20 parts, Pseudobulbus Pholidotae Chinensis 30 parts and Herba Peperomiae Dindygulensis 16 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Ilicis Purpureae 16
Part, Rhizoma Gymnadeniae 29 parts, Herba Portulacae 22 parts, Herba Lobeliae Chinensis 21 parts, Herba Salsolae Collinae 14 parts, Herba galii veri 20
Part, Radix Crotonis Crassifolii 8 parts, rabbit hair Artemisia 26 parts, Folium Ilicis 10 parts, Pericarpium syzygii 30 parts, Herba Vernoniae Cinereae 15 parts,
Herba Equiseti Arvinsis 25 parts, Rhizoma valerianae latifoliae 15 parts, Rhizoma Schizocapsae Plantagineae 10 parts, Herba Thuniae Albae 12 parts, Herba Passiflorae Wilsonii 14 parts, Radix seu Fructus Rosae Sericeae
28 parts, Semen setariae 22 parts, Pseudobulbus Pholidotae Chinensis 28 parts and Herba Peperomiae Dindygulensis 18 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2~
The determining alcohol of 4 times is the ethanol of 85~95%, is heated to reflux 1~3 hour, extracts, and filters acquisition first
Extracting solution;Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1~2 times be 85~
The ethanol of 95%, is heated to reflux 1~3 hour, extracts, and filters and obtains the second extracting solution;Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders obtained by second step, add relative to its quality 0.1~0.3 times is micro-
Crystalline cellulose, 0.05~0.15 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletizes,
It is dried, adds relative to micropowders quality 0.005~0.05 times of magnesium stearate, granulate, tabletting, system
Become.
Wherein, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4~the alcohol of 8 times
Concentration is the ethanol of 85%~95%, is heated to boiling reflux 3~5 hours, filters, use percolation with
The speed slowly percolation of per minute 1~2ml, collects percolate, subsequently in vacuum 0.06~0.09Mpa
Under to be evaporated to relative density when 50~60 DEG C be the mastic of 1.04~1.10, be spray-dried, spraying
The inlet temperature 160 of drying machine~175 DEG C, leaving air temp 80~85 DEG C, be ground into powder subsequently, make
Dried cream powder;
Step 2: add relative to dried cream powder quality 0.2~the cane sugar powder of 0.4 times in the dried cream powder obtained
With the dextrin of 0.1~0.2 times, make granule, be dried in 40~50 DEG C, it is thus achieved that granule.
Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied
Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this
Execute.
Embodiment 1: tablet
Take Fructus Ilicis Purpureae 160g, Rhizoma Gymnadeniae 290g, Herba Portulacae 220g, Herba Lobeliae Chinensis 210g, Herba Salsolae Collinae 140g,
Herba galii veri 200g, Radix Crotonis Crassifolii 80g, rabbit hair Artemisia 260g, Folium Ilicis 100g, Pericarpium syzygii 300g, typhoid fever
Grass 150g, Herba Equiseti Arvinsis 250g, Rhizoma valerianae latifoliae 150g, Rhizoma Schizocapsae Plantagineae 100g, Herba Thuniae Albae 120g, Herba Passiflorae Wilsonii 140g,
Radix seu Fructus Rosae Sericeae 280g, Semen setariae 220g, Pseudobulbus Pholidotae Chinensis 280g and Herba Peperomiae Dindygulensis 180g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 3
The ethanol that determining alcohol is 95% again, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution;
Filter the medicinal residues obtained and add the ethanol that determining alcohol is 95% relative to described medicinal residues quality 1 times, add
Hot reflux 2 hours, extracts, and filters and obtains the second extracting solution;First extracting solution and the second extracting solution are closed
And, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that the micropowders of 400 mesh;
3rd step, the micropowders that second step is obtained, add fine relative to the crystallite of its quality 0.1 times
Dimension element, 0.1 times of lactose, starch of 0.2 times, sieve, and mix homogeneously is pelletized, and is dried, and adds relatively
In 0.03 times of magnesium stearate of micropowders quality, granulate, tabletting, make.
Embodiment 2: granule
Take Fructus Ilicis Purpureae 130g, Rhizoma Gymnadeniae 320g, Herba Portulacae 180g, Herba Lobeliae Chinensis 240g, Herba Salsolae Collinae 160g,
Herba galii veri 170g, Radix Crotonis Crassifolii 120g, rabbit hair Artemisia 240g, Folium Ilicis 150g, Pericarpium syzygii 280g, typhoid fever
Grass 180g, Herba Equiseti Arvinsis 220g, Rhizoma valerianae latifoliae 170g, Rhizoma Schizocapsae Plantagineae 70g, Herba Thuniae Albae 150g, Herba Passiflorae Wilsonii 170g,
Radix seu Fructus Rosae Sericeae 300g, Semen setariae 200g, Pseudobulbus Pholidotae Chinensis 300g and Herba Peperomiae Dindygulensis 160g;
Its preparation method comprises the following steps:
Step one: mixed in described ratio by described raw medicinal material, add relative to 5 times of mixture is pure and strong
Degree is the ethanol of 90%, is heated to boiling reflux 4 hours, filters, and uses percolation with 2ml per minute
Speed slowly percolation, collect percolate, when being evaporated to 55 DEG C under vacuum 0.07Mpa subsequently
Relative density is the mastic of 1.10, is spray-dried, the inlet temperature of spray dryer 170 DEG C, goes out pathogenic wind-warm
Spend 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: add the cane sugar powder and 0.2 relative to dried cream powder quality 0.2 times in the dried cream powder obtained
Dextrin again, makes granule, is dried in 40 DEG C, it is thus achieved that granule.
Toxicity test:
Acute toxicity test: application NIH mice 60, male and female half and half, body weight 20~28g, carries out urgency
Property toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group is prohibited before experiment
Eat 12 hours;The tablet dissolved prepared by embodiments of the invention 1 is in water, and (concentration is 6.58g
Crude drug/ml, maximum concentration) gavage, gavage volume is that (i.e. unit dosage form is 32.9 lifes to 5ml/kg
Medicine/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours,
Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that:
Comparing with matched group, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic shape
Condition, diet, drinking-water, body weight increase the most normal.The tablet LD50 > 32.9 of the Mouse oral gavage present invention
Crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is
5.2g crude drug/day/people, adult's body weight is in terms of 60KG, and average dosage is 0.087g crude drug/kg/ day.
By weighing machine: the dosis tolerata of the Chinese medicine of mice (average weight is based on 24g) the oral administration gavage present invention is for facing
756 times of bed consumption.Therefore the Chinese medicine narcotic substance acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: three groups of mices (often group 20) are pressed by the tablet of the embodiment of the present invention 1
9.25,16.48 and 34.52g crude drugs/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times)
And after drug withdrawal 4 weeks, result shows: Chinese medicine preparation of the present invention to the hair of mice, behavior, defecation,
The indexs such as body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, internal organs
Naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, little
The each internal organs of Mus are all without substantially changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, stop
Difference reaction, application safety is not had after medicine yet.
Clinical data:
Case selection: fetch the 120 example diseases caused by retention of fluid icepro cardioid patients with arrhythmia coming from the court's cardiological patients,
Man 58 people, female 62 people;Age 20~66 years old.120 example patients are randomly divided into treatment group and Western medicine comparison
Group, treatment group 60 people, male 29 people, female 31 people;Age 20~64 years old.Western medicine group 60 people,
Man 29 people, female 31 people;Age 21~66 years old.Treatment group and matched group are in sex, age and clinical condition
The aspects such as shape aspect compare no difference of science of statistics, have comparability.
Diagnostic criteria: meet following Western medicine diagnose standard, Syndrome Types of TCM standard and exclusion standard.
Western medicine diagnose standard: 1, there is typical cardiopalmus symptom;2, through more than 2 times tranquil electrocardiograms or 24
Hr Ambulatory EKG Monitoring inspection is diagnosed as the hearts such as frequent premature beat, paroxysmal tachycardia, rapidity atrial fibrillation
Restrain not normal;3,18~78 years old;4, Liver and kidney function is normal.
Syndrome Types of TCM standard: diseases caused by retention of fluid insults cardioid: palpitation and dizziness, dyspnea with rapid and short breath difficulty crouches, gastral cavity painful abdominal mass uncomfortable in chest, cold physique limb
Cold, oliguria, or edema of lower limbs, thirst but no desire to drink, nausea and salivation.Light red tongue, white, slippery and moist fur, stringy and rolling pulse.
Exclusion standard: 1, severe cardiac functional defect;2, II °, III ° of atrioventricular block;3, persistence
Ventricular tachycardia, room are flutterred, quiver in room;4, sinus bradycardia;5, iodine preparation allergy.
Therapeutic Method:
Matched group: oral hydrochloride amiodarone sheet, each 1 (0.2g), three times a day;Change into after 7 days
Each 1, every day 2 times;Each 1 is changed into, every day 1 time after 14 days;It within 4 weeks, it is 1 course for the treatment of.
Treatment group: on the basis of matched group conventional western medicine is treated, takes the sheet of the embodiment of the present invention 1 preparation
Agent, three times a day, each 3.It within 4 weeks, it is 1 course for the treatment of.
The standard of curative effect evaluation: clinical cure: clinical symptom disappearance, 24h dynamic ecg monitoring premature beat is complete
Portion disappears or reduces more than 75%.Take a turn for the better: premature beat reduces 50%~75%, clinical symptom disappearance or improvement.
Invalid: before and after medication unchanged or change less.
Therapeutic outcome: be shown in Table 1.
1 liang of table group treats Clinical efficacy comparison (example (%)) after 1 course for the treatment of respectively
Group | Number of cases | Recovery from illness (%) | Take a turn for the better | Invalid | Total effective rate |
Treatment group | 60 | 35 (58.3%) | 23 | 2 | 58 (96.7%) |
Matched group | 60 | 19 (31.7%) | 30 | 11 | 49 (81.7%) |
As it can be seen from table 1 use the Chinese medicine associating western medicine diseases caused by retention of fluid of the present invention to insult cardioid arrhythmia,
Relative to using merely Western medicine, on therapeutic effect, have and be markedly improved.
Untoward reaction: hepatic and renal function injure or other untoward reaction all do not occur during two groups of patient treatments.
Relapse rate is added up: 35 examples and the 19 example follow-up of patients 6 of matched group recovery from illness to the recovery from illness for the treatment of group
Individual month, result was added up, and treatment group 35 example is without recurrence, and relapse rate is 0;Matched group 19 example patient is multiple
Send out 3 people, relapse rate 15.8%.
Model case: Song, male, 52 years old, because cardiopalmus, dizziness and uncomfortable in chest being admitted to hospital are seen a doctor, through electrocardio
Figure and 24h ambulatory electrocardiogram etc. check and are diagnosed as arrhythmia, then according to TCM pulse diagnosis, and palpitation and dizziness,
Dyspnea with rapid and short breath difficulty crouches, gastral cavity painful abdominal mass uncomfortable in chest, coldness of the body with chills, oliguria, nausea and salivation, light red tongue, white, slippery and moist fur, arteries and veins
Stringy and rolling pulse, further typing is that diseases caused by retention of fluid insults cardioid arrhythmia.Take Amiodarone Hydrochloride sheet and Chinese medicine of the present invention
The tablet of example of formulations 1, treats 3 weeks, clinical symptom disappearance, 24h dynamic ecg monitoring premature beat
All disappear, continue to take drug withdrawal in 1 week, cure, follow up a case by regular visits to 6 months not recur.
The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form
Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above
Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on
Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention,
Still fall within the protection domain of technical solution of the present invention.
Claims (9)
1. a treatment diseases caused by retention of fluid insults the ARR Chinese medicine of cardioid, it is characterised in that include following crude drug
Material: Fructus Ilicis Purpureae, Rhizoma Gymnadeniae, Herba Portulacae, Herba Lobeliae Chinensis, Herba Salsolae Collinae, Herba galii veri, Radix Crotonis Crassifolii, rabbit hair Artemisia,
Folium Ilicis, Pericarpium syzygii, Herba Vernoniae Cinereae, Herba Equiseti Arvinsis, Rhizoma valerianae latifoliae, Rhizoma Schizocapsae Plantagineae, Herba Thuniae Albae, Herba Passiflorae Wilsonii, Radix seu Fructus Rosae Sericeae,
Semen setariae, Pseudobulbus Pholidotae Chinensis and Herba Peperomiae Dindygulensis.
2. Chinese medicine as claimed in claim 1, it is characterised in that the weight of each raw medicinal material in described Chinese medicine
Amount portion rate is: Fructus Ilicis Purpureae 10~20 parts, Rhizoma Gymnadeniae 25~35 parts, and Herba Portulacae 15~25 parts are half of
Lotus 20~30 parts, Herba Salsolae Collinae 10~20 parts, Herba galii veri 13~23 parts, Radix Crotonis Crassifolii 6~16 parts, the rabbit hair
Artemisia 20~30 parts, Folium Ilicis 10~20 parts, Pericarpium syzygii 25~35 parts, Herba Vernoniae Cinereae 12~22 parts, ask
Chaste tree 20~30 parts, Rhizoma valerianae latifoliae 10~20 parts, Rhizoma Schizocapsae Plantagineae 5~15 parts, Herba Thuniae Albae 10~20 parts, Herba Passiflorae Wilsonii
10~20 parts, Radix seu Fructus Rosae Sericeae 22~32 parts, Semen setariae 16~26 parts, Pseudobulbus Pholidotae Chinensis 25~35 parts and Herba Peperomiae Dindygulensis
10~20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that each raw medicinal material in described Chinese medicine
Ratio of weight and number be: Fructus Ilicis Purpureae 12~17 parts, Rhizoma Gymnadeniae 28~33 parts, Herba Portulacae 17~22 parts,
Herba Lobeliae Chinensis 20~25 parts, Herba Salsolae Collinae 13~18 parts, Herba galii veri 15~20 parts, Radix Crotonis Crassifolii 8~13 parts,
Rabbit hair Artemisia 22~27 parts, Folium Ilicis 10~15 parts, Pericarpium syzygii 27~32 parts, Herba Vernoniae Cinereae 14~19 parts,
Herba Equiseti Arvinsis 20~25 parts, Rhizoma valerianae latifoliae 13~18 parts, Rhizoma Schizocapsae Plantagineae 6~11 parts, Herba Thuniae Albae 12~17 parts, half
Leaf 13~18 parts, Radix seu Fructus Rosae Sericeae 26~31 parts, Semen setariae 18~23 parts, Pseudobulbus Pholidotae Chinensis 27~32 parts and stone Cicadae
Grass 15~20 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterised in that each raw medicinal material in described Chinese medicine
Ratio of weight and number be: Fructus Ilicis Purpureae 13 parts, Rhizoma Gymnadeniae 32 parts, Herba Portulacae 18 parts, Herba Lobeliae Chinensis 24 parts,
Herba Salsolae Collinae 16 parts, Herba galii veri 17 parts, Radix Crotonis Crassifolii 12 parts, rabbit hair Artemisia 24 parts, Folium Ilicis 15 parts, Pu
Peach shell 28 parts, Herba Vernoniae Cinereae 18 parts, Herba Equiseti Arvinsis 22 parts, Rhizoma valerianae latifoliae 17 parts, Rhizoma Schizocapsae Plantagineae 7 parts, Herba Thuniae Albae 15
Part, Herba Passiflorae Wilsonii 17 parts, Radix seu Fructus Rosae Sericeae 30 parts, Semen setariae 20 parts, Pseudobulbus Pholidotae Chinensis 30 parts and Herba Peperomiae Dindygulensis 16 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterised in that each raw medicinal material in described Chinese medicine
Ratio of weight and number be: Fructus Ilicis Purpureae 16 parts, Rhizoma Gymnadeniae 29 parts, Herba Portulacae 22 parts, Herba Lobeliae Chinensis 21 parts,
Herba Salsolae Collinae 14 parts, Herba galii veri 20 parts, Radix Crotonis Crassifolii 8 parts, rabbit hair Artemisia 26 parts, Folium Ilicis 10 parts, Pu
Peach shell 30 parts, Herba Vernoniae Cinereae 15 parts, Herba Equiseti Arvinsis 25 parts, Rhizoma valerianae latifoliae 15 parts, Rhizoma Schizocapsae Plantagineae 10 parts, Herba Thuniae Albae
12 parts, Herba Passiflorae Wilsonii 14 parts, Radix seu Fructus Rosae Sericeae 28 parts, Semen setariae 22 parts, Pseudobulbus Pholidotae Chinensis 28 parts and Herba Peperomiae Dindygulensis 18
Part.
6. the Chinese medicine as described in claim 1 to 5, it is characterised in that when the dosage form of described Chinese medicine is sheet
During agent, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2~
The determining alcohol of 4 times is the ethanol of 85~95%, is heated to reflux 1~3 hour, extracts, and filters acquisition first
Extracting solution;Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1~2 times be 85~
The ethanol of 95%, is heated to reflux 1~3 hour, extracts, and filters and obtains the second extracting solution;Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders obtained by second step, add relative to its quality 0.1~0.3 times is micro-
Crystalline cellulose, 0.05~0.15 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletizes,
It is dried, adds relative to micropowders quality 0.005~0.05 times of magnesium stearate, granulate, tabletting, system
Become.
7. the Chinese medicine as described in claim 1 to 5, it is characterised in that when the dosage form of described Chinese medicine is
During granule, its preparation method comprises the following steps:
Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4~the alcohol of 8 times
Concentration is the ethanol of 85%~95%, is heated to boiling reflux 3~5 hours, filters, use percolation with
The speed slowly percolation of per minute 1~2ml, collects percolate, subsequently in vacuum 0.06~0.09Mpa
Under to be evaporated to relative density when 50~60 DEG C be the mastic of 1.04~1.10, be spray-dried, spraying
The inlet temperature 160 of drying machine~175 DEG C, leaving air temp 80~85 DEG C, be ground into powder subsequently, make
Dried cream powder;
Step 2: add relative to dried cream powder quality 0.2~the cane sugar powder of 0.4 times in the dried cream powder obtained
With the dextrin of 0.1~0.2 times, make granule, be dried in 40~50 DEG C, it is thus achieved that granule.
8. the preparation method of Chinese medicine described in a claim 1 to 5, it is characterised in that described Chinese medicine
Dosage form is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2~
The determining alcohol of 4 times is the ethanol of 85~95%, is heated to reflux 1~3 hour, extracts, and filters acquisition first
Extracting solution;Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1~2 times be 85~
The ethanol of 95%, is heated to reflux 1~3 hour, extracts, and filters and obtains the second extracting solution;Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders obtained by second step, add relative to its quality 0.1~0.3 times is micro-
Crystalline cellulose, 0.05~0.15 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletizes,
It is dried, adds relative to micropowders quality 0.005~0.05 times of magnesium stearate, granulate, tabletting, system
Become.
9. the preparation method of Chinese medicine described in a claim 1 to 5, it is characterised in that described Chinese medicine
Dosage form is granule, and its preparation method comprises the following steps:
Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4~the alcohol of 8 times
Concentration is the ethanol of 85%~95%, is heated to boiling reflux 3~5 hours, filters, use percolation with
The speed slowly percolation of per minute 1~2ml, collects percolate, subsequently in vacuum 0.06~0.09Mpa
Under to be evaporated to relative density when 50~60 DEG C be the mastic of 1.04~1.10, be spray-dried, spraying
The inlet temperature 160 of drying machine~175 DEG C, leaving air temp 80~85 DEG C, be ground into powder subsequently, make
Dried cream powder;
Step 2: add relative to dried cream powder quality 0.2~the cane sugar powder of 0.4 times in the dried cream powder obtained
With the dextrin of 0.1~0.2 times, make granule, be dried in 40~50 DEG C, it is thus achieved that granule.
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Title |
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南京中医药大学编著: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
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