CN105942428A - 一种降血压的复配甜味剂 - Google Patents
一种降血压的复配甜味剂 Download PDFInfo
- Publication number
- CN105942428A CN105942428A CN201610309782.6A CN201610309782A CN105942428A CN 105942428 A CN105942428 A CN 105942428A CN 201610309782 A CN201610309782 A CN 201610309782A CN 105942428 A CN105942428 A CN 105942428A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- blood pressure
- medicine extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036772 blood pressure Effects 0.000 title claims abstract description 32
- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 235000003599 food sweetener Nutrition 0.000 title claims abstract description 24
- 239000003765 sweetening agent Substances 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 67
- 239000000284 extract Substances 0.000 claims abstract description 45
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 23
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 23
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 22
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 22
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 22
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 14
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 14
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 14
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 14
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000010447 xylitol Nutrition 0.000 claims abstract description 14
- 239000000811 xylitol Substances 0.000 claims abstract description 14
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 14
- 229960002675 xylitol Drugs 0.000 claims abstract description 14
- 239000001512 FEMA 4601 Substances 0.000 claims abstract description 13
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 claims abstract description 13
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000019203 rebaudioside A Nutrition 0.000 claims abstract description 13
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims description 79
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 54
- 210000000582 semen Anatomy 0.000 claims description 48
- 239000000706 filtrate Substances 0.000 claims description 40
- 238000001914 filtration Methods 0.000 claims description 34
- 239000012466 permeate Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 27
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 25
- 239000012528 membrane Substances 0.000 claims description 25
- 241000208340 Araliaceae Species 0.000 claims description 23
- 239000000919 ceramic Substances 0.000 claims description 23
- 239000009636 Huang Qi Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 17
- 238000010792 warming Methods 0.000 claims description 15
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 14
- 229940013618 stevioside Drugs 0.000 claims description 14
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 14
- 235000019202 steviosides Nutrition 0.000 claims description 14
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 13
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 10
- 239000012065 filter cake Substances 0.000 claims description 10
- 238000001556 precipitation Methods 0.000 claims description 10
- 238000000108 ultra-filtration Methods 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 6
- 229930182470 glycoside Natural products 0.000 claims description 6
- 150000002338 glycosides Chemical class 0.000 claims description 6
- 230000014759 maintenance of location Effects 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 241000218628 Ginkgo Species 0.000 claims 4
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 241001251949 Xanthium sibiricum Species 0.000 claims 1
- 229960002737 fructose Drugs 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 abstract description 22
- 244000194101 Ginkgo biloba Species 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 19
- 210000003734 kidney Anatomy 0.000 abstract description 15
- 210000004185 liver Anatomy 0.000 abstract description 13
- 210000005036 nerve Anatomy 0.000 abstract description 7
- 230000001105 regulatory effect Effects 0.000 abstract description 5
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract description 4
- 102000017910 Adrenergic receptor Human genes 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 4
- 230000002889 sympathetic effect Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 241000427159 Achyranthes Species 0.000 abstract description 2
- 240000005717 Dioscorea alata Species 0.000 abstract description 2
- 244000241838 Lycium barbarum Species 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 230000027939 micturition Effects 0.000 abstract description 2
- 235000019640 taste Nutrition 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 240000004371 Panax ginseng Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 230000010339 dilation Effects 0.000 abstract 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 abstract 1
- 229940107187 fructooligosaccharide Drugs 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000845 maltitol Substances 0.000 abstract 1
- 235000010449 maltitol Nutrition 0.000 abstract 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 abstract 1
- 229940035436 maltitol Drugs 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 description 14
- 235000009508 confectionery Nutrition 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 229940079593 drug Drugs 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 239000005720 sucrose Substances 0.000 description 7
- 206010020772 Hypertension Diseases 0.000 description 6
- 208000004880 Polyuria Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 241000628997 Flos Species 0.000 description 5
- 206010033557 Palpitations Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- 241000721047 Danaus plexippus Species 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000006837 decompression Effects 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 210000000629 knee joint Anatomy 0.000 description 4
- -1 oligofructose Chemical compound 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 4
- 239000011886 peripheral blood Substances 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000003014 reinforcing effect Effects 0.000 description 4
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 241000594394 Hedyotis Species 0.000 description 2
- 241000825107 Hierochloe Species 0.000 description 2
- 235000015466 Hierochloe odorata Nutrition 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 2
- 208000012886 Vertigo Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000004531 blood pressure lowering effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 2
- 235000021286 stilbenes Nutrition 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 231100000889 vertigo Toxicity 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 244000205574 Acorus calamus Species 0.000 description 1
- 235000006480 Acorus calamus Nutrition 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000189115 Catananche Species 0.000 description 1
- 241000183712 Cerinthe major Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 241000480045 Citrus suavissima Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 241001236122 Coprinopsis atramentaria Species 0.000 description 1
- 241000565633 Coprinus sterquilinus Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 241000218791 Ginkgoaceae Species 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241001278898 Glycyrrhiza inflata Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000004356 Hysteria Diseases 0.000 description 1
- 206010022714 Intestinal ulcer Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- GIPHUOWOTCAJSR-UHFFFAOYSA-N Rebaudioside A. Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1OC(C1O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O GIPHUOWOTCAJSR-UHFFFAOYSA-N 0.000 description 1
- 241000219100 Rhamnaceae Species 0.000 description 1
- CZMRCDWAGMRECN-UHFFFAOYSA-N Rohrzucker Natural products OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O CZMRCDWAGMRECN-UHFFFAOYSA-N 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241001238244 Saxidomus purpuratus Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 240000000377 Tussilago farfara Species 0.000 description 1
- 235000004869 Tussilago farfara Nutrition 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 208000012839 conversion disease Diseases 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008359 toxicosis Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 60‑80份，木糖醇5‑7份，低聚果糖3‑5份，海藻糖4‑6份，麦芽糖醇5‑7份，中药提取物10‑20份；其中，中药提取物的原料包括：枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草。本发明口感好，能通过协调扩张外周血管、抑制外周交感神经、阻断肾上腺素受体和利尿的作用，全面降压；并且能滋补肝肾，益气健脾，调节身体的机能，从本质上改善身体状况，标本兼治，达到很好的降血压效果，且无毒副作用。
Description
技术领域
本发明涉及甜味剂技术领域，尤其涉及一种降血压的复配甜味剂。
背景技术
甜味剂是食品工业和医疗保健中不可或缺的重要原料，然而占据甜味剂市场居多的人工合成甜味剂可能对人体有致癌、治病的副作用，因而已被许多国家限制使用，而蔗糖的过多食用则导致越来越多的高血压等疾病的发生。
高血压是一种发病率、致残率、死亡率较高的疾病。目前，治疗高血压需长期服药，而且降血压的化学合成药物大都存在作用时间短、毒副作用大、依赖性较强，治疗效果存在局限性等问题。因此需要提供一种新的甜味剂，既能改善口感，又能降低血压。
甜菊糖苷是一种从菊科草本植物甜叶菊的叶片中提取的一种纯天然、高甜度、低热值的食品添加剂。是继蔗糖、甜菜糖之后的第三类糖源，其甜度是蔗糖的200-300倍，但热量仅为蔗糖的1/300，可广泛运用于食品、饮料、酿酒、医药等几乎所有糖领域中。甜菊糖苷主要成分为甜菊苷和莱鲍迪苷A。莱鲍迪苷A在甜度、理化性质等方面优于其他甜菊糖苷，而且口感接近蔗糖，是蔗糖的极佳替代品；甜菊苷具有清热、利尿、降血压、降血糖调节味酸的功效，可以用来做甜味剂，但是具有后苦味。
发明内容
基于背景技术存在的技术问题，本发明提出了一种降血压的复配甜味剂，本发明口感好，能通过协调扩张外周血管、抑制外周交感神经、阻断肾上腺素受体和利尿的作用，全面降压；并且能滋补肝肾，益气健脾，调节身体的机能，从本质上改善身体状况，标本兼治，达到很好的降血压效果，且无毒副作用。
本发明提出的一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A60-80份，甜菊苷10-20份，木糖醇5-7份，低聚果糖3-5份，海藻糖4-6份，麦芽糖醇5-7份，中药提取物10-20份；
其中，中药提取物的原料包括：枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草。
枸杞子，别名为苟起子、甜菜子、杞子、红青椒、构蹄子、狗***等，为茄科植物宁夏枸杞的干燥成熟果实。味甘，性平；入肝、肾经。能滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。枸杞子还具有增强机体免疫力，抗氧化，降血脂，降血糖的作用。
黄芪，别名为绵芪、绵黄芪、黄耆等，为豆科草本植物蒙古黄芪、膜荚黄芪的干燥根。味甘，性温；入肺、脾经。能补气固表，托疮生肌。主治体虚自汗，久泻，脱肛，子宫脱垂，慢性肾炎，体虚浮肿，慢性溃疡，疮口久不愈合。
人参，别名为棒锤、山参、园参、参叶、人衔、鬼盖、土精、神草等，为五加科植物人参的根。味甘、苦，性温；入肺、脾经。能补气，固脱，生津，安神，益智。用于气短喘促，心悸健忘，口渴多汗，食少无力，一切急慢性疾病及失血后引起的休克、虚脱。
银杏叶，别名为飞蛾叶、鸭脚子等，为银杏科植物银杏的干燥叶。味甘、苦、涩，性平；入心、肺经。能敛肺，平喘，活血化瘀，止痛。用于肺虚咳喘；冠心病，心绞痛，高血脂。银杏还能增强记忆力。
决明子，别名为马蹄决明、钝叶决明、假绿豆、草决明、羊明等，为决明或小决明的干燥成熟种子。味甘、苦，性凉；入肝、肾经。能清热明目，润肠通便。用于目赤涩痛，羞明多泪，头痛眩晕，目暗不明，大便秘结，高血压。
牛膝，别名为怀牛膝、牛髁膝、山苋菜、对节草、红牛膝、杜牛膝、土牛膝等，为苋科植物牛膝的根。味酸、苦，性平；入肝、肾经。能补肝肾，强筋骨，逐瘀通经，引血下行。用于腰膝酸痛，筋骨无力，经闭症瘕，肝阳眩晕。
泽泻，别名为水泽、如意花、车苦菜、天鹅蛋、天秃等，为泽泻科植物泽泻的块茎。味甘，性寒；入肾、膀胱经。能利水渗湿；泄热通淋。用于小便不利；热淋涩痛；水肿胀满；泄泻；痰饮眩晕；遗精。
熟地，别名为熟地黄等，为玄参科植物地黄的块根经加工炮制而成。通常以酒、砂仁或陈皮为辅料经反复蒸晒，至内外色黑油润，质地柔软粘腻。味甘，性温；入肝、肾经。能滋阴，补血。用于阴虚血少，腰膝痿弱，劳嗽骨蒸，遗精，崩漏，***，消渴，溲数，耳聋，目昏。
山药，别名为怀山药、淮山药、土薯、山薯、山芋、玉延等，为薯蓣科薯蓣属植物山药的根茎。味甘，性平；入脾、肺、肾经。能补脾养胃，生津益肺，补肾填精。用于脾虚食少，便溏久泻，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
茯苓，别名为茯苓个、茯苓皮、茯苓块、赤茯苓、白茯苓、茯菟、茯灵等，为多孔菌科真菌茯苓的干燥菌核。味甘、淡，性平；入心、肺、脾经。能利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
白术，别名为于术、冬术、浙术、种术、山蓟等，为菊科植物白术的干燥根茎。味甘、苦，性温；入胃、脾经。能补脾，益胃，燥湿，和中，安胎。用于脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。
灵芝草，别名为三秀、茵、芝等，为多孔菌科植物紫芝或赤芝的全株。味甘，性平；入心、脾、肺经。能益气健脾，养心安神，止咳平喘。用于虚劳羸弱，食欲不振，心悸怔忡，失眠健忘，肺虚咳喘；完心病心绞痛、高血压及高血脂症。
陈皮，别名为橘皮、贵老、红皮、黄橘皮、广橘皮、新会皮、柑皮、广陈皮等，为芸香科植物橘及其栽培变种的成熟果皮。味辛、苦，性温；入肺、脾经。能理气健脾，燥湿化痰。用于胸脘胀满，食少吐泻，咳嗽痰多。
酸枣仁，别名为山枣仁、山酸枣、枣仁、酸枣核等，为鼠李科植物酸枣的种子。味甘，性平；入心、胆、肝经。能养肝，宁心，安神，敛汗。用于虚烦不眠，惊悸怔忡，烦渴，虚汗。
甘草，别名为甜草根、红甘草、粉甘草、粉草、美草、蜜甘、蜜草、蕗草、国老、灵通、甜草、甜根子、棒草等，为双子叶植物豆科甘草，胀果甘草或光果甘草的根及根茎。味甘，性平；入胃、肺、脾经。能清热解毒，润肺止咳，调和诸药；炙甘草能补脾益气。用于咽喉肿痛，咳嗽，脾胃虚弱，胃、十二指肠溃疡，肝炎，癔病，痈疖肿毒，药物及食物中毒。
优选地，其原料按重量份包括：莱鲍迪苷A 65-75份，甜菊苷13-17份，木糖醇5.5-6.5份，低聚果糖3.5-4.5份，海藻糖4.5-5.5份，麦芽糖醇5.5-6.5份，中药提取物12-18份。
优选地，中药提取物的原料按重量份包括：枸杞子4-8份，黄芪4-6份，人参6-9份，银杏叶3-5份，决明子2-4份，牛膝3-5份，泽泻2-4份，熟地4-6份，山药6-9份，茯苓5-7份，白术2-4份，灵芝草3-4份，陈皮1-3份，酸枣仁1-2份，甘草4-6份。
优选地，在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温，超声，过滤得到一次滤渣和一次滤液，取一次滤液用陶瓷膜过滤得到一次透过液，减压干燥得到物料A；将物料A纯化得到物料B；向一次滤渣中加入乙醇水溶液，升温，超声，过滤得到二次滤渣和二次滤液，取二次滤液用陶瓷膜过滤得到二次透过液，取二次透过液纯化，减压干燥得到物料C；向二次滤渣中加入乙醇，升温，超声，过滤得到三次滤渣和三次滤液，取三次滤液用陶瓷膜过滤得到三次透过液，减压干燥得到物料D；将物料D纯化得到物料E；将物料B、物料C、物料E粉碎混匀得到中药提取物。
优选地，在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温至80-90℃，超声1-2h，过滤得到一次滤渣和一次滤液，取一次滤液用陶瓷膜过滤得到一次透过液，减压干燥得到物料A；将物料A溶于水中，加丙酮沉淀，过滤，将滤饼真空干燥得到物料B；向一次滤渣中加入质量分数为40-60wt％乙醇水溶液，升温至30-50℃，超声2-3h，过滤得到二次滤渣和二次滤液，取二次滤液用陶瓷膜过滤得到二次透过液，取二次透过液用超滤膜过滤得到超滤透过液，减压干燥得到物料C；向二次滤渣中加入乙醇，升温至30-50℃，超声40-60min，过滤得到三次滤渣和三次滤液，取三次滤液用陶瓷膜过滤得到三次透过液，减压干燥得到物料D；将物料D溶于乙醇中，加水沉淀，过滤，将滤饼真空干燥得到物料E；将物料B、物料C、物料E粉碎至100-300目混匀得到中药提取物。
优选地，在中药提取物的制备过程中，陶瓷膜的孔径为0.1-0.3μm。
优选地，在中药提取物的制备过程中，超滤膜的分子截留量为3000-4000D。
优选地，在中药提取物的制备过程中，在物料A中，混合物和水的重量比为1：20-30。
优选地，在中药提取物的制备过程中，在物料C中，混合物和乙醇水溶液的重量比为1：25-35。
优选地，在中药提取物的制备过程中，在物料D中，混合物和乙醇的重量比为1：15-25。
优选地，其原料按重量份包括：莱鲍迪苷A 70份，甜菊苷15份，木糖醇6份，低聚果糖4份，海藻糖5份，麦芽糖醇6份，中药提取物15份。
优选地，中药提取物的原料按重量份包括：枸杞子5-7份，黄芪4.5-5.5份，人参7-8份，银杏叶3.5-4.5份，决明子2.5-3.5份，牛膝3.5-4.5份，泽泻2.5-3.5份，熟地4.5-5.5份，山药7-8份，茯苓5.5-6.5份，白术2.5-3.5份，灵芝草3.3-3.7份，陈皮1.5-2.5份，酸枣仁1.3-1.7份，甘草4.5-5.5份。
优选地，中药提取物的原料按重量份包括：枸杞子6份，黄芪5份，人参7.5份，银杏叶4份，决明子3份，牛膝4份，泽泻3份，熟地5份，山药7.5份，茯苓6份，白术3份，灵芝草3.5份，陈皮2份，酸枣仁1.5份，甘草5份。
上述在中药提取物的制备过程中，在物料B中，水的作用是溶解，丙酮的作用是沉淀，不规定水和丙酮的用量，根据具体操作确定其用量。
上述在中药提取物的制备过程中，在物料E中，乙醇的作用是溶解，水的作用是沉淀，不规定乙醇和水的用量，根据具体操作确定其用量。
本发明选用的木糖醇具有防龋齿、不引起血糖波动，改善肠道功能，促进肠道益生菌的生长，改善肝功能等作用；低聚果糖既保持了蔗糖的纯正甜味性质，又比蔗糖甜味清爽，还具有调节肠道菌群，增殖双歧杆菌，促进钙的吸收，调节血脂，免疫调节，抗龋齿等保健功能的新型甜味剂；海藻糖对生物体具有神奇的保护作用，可以在高温、高寒、高渗透压及干燥失水等恶劣环境条件下在细胞表面能形成独特的保护膜，有效地保护蛋白质分子不变性失活，还具有防止食品劣化、保持食品新鲜风味、提升食品品质的作用；麦芽糖醇极难形成龋齿，能促进钙吸收、促进胰岛素分泌，抑制体内脂肪过多积累；莱鲍迪苷A、甜菊苷、木糖醇、低聚果糖、海藻糖、麦芽糖醇相互配合，可以改善甜菊苷的后苦味，改善本发明的口感，并能增加本发明的稳定性；枸杞子、黄芪、人参、银杏叶为君药，能在滋补肝肾、补气的同时，通过扩张外周血管、抑制外周交感神经、阻断肾上腺素受体，降低血压；决明子、牛膝、泽泻、熟地为臣药，能辅助君药进一步补肝肾，并且具有利尿的作用，可以配合君药的扩张外周血管、抑制外周交感神经、阻断肾上腺素受体的作用，达到很好的降压效果；山药、茯苓、白术、灵芝草为佐药，可以在辅助君药和臣药降压的同时，益气健脾、和胃、养心安神；陈皮、酸枣仁、甘草为使药，能理气、安神、调和诸药；上述诸药相互配合，扩张外周血管、抑制外周交感神经、阻断肾上腺素受体和利尿的作用，相互协调，可以全面降压；并且能滋补肝肾，益气健脾，调节身体的机能，从本质上改善身体状况，达到降压的作用，标本兼治，且无毒副作用；上述诸药可以和莱鲍迪苷A、甜菊苷相互配合，从而进一步增加本发明的降压效果；莱鲍迪苷A、甜菊苷、木糖醇、低聚果糖、海藻糖、麦芽糖醇与中药提取物相互配合，可以改善中药提取物造成的不良口感，保持本发明的口感。
具体实施方式
下面，通过具体实施例对本发明的技术方案进行详细说明。
实施例1
一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 70份，甜菊苷15份，木糖醇6份，低聚果糖4份，海藻糖5份，麦芽糖醇6份，中药提取物15份；
其中，中药提取物的原料包括：枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草。
实施例2
一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 60份，甜菊苷20份，木糖醇5份，低聚果糖5份，海藻糖4份，麦芽糖醇7份，中药提取物10份；
其中，中药提取物的原料按重量份包括：枸杞子8份，黄芪4份，人参9份，银杏叶3份，决明子4份，牛膝3份，泽泻4份，熟地4份，山药9份，茯苓5份，白术4份，灵芝草3份，陈皮3份，酸枣仁1份，甘草6份。
实施例3
一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 80份，甜菊苷10份，木糖醇7份，低聚果糖3份，海藻糖6份，麦芽糖醇5份，中药提取物20份；
其中，中药提取物的原料按重量份包括：枸杞子4份，黄芪6份，人参6份，银杏叶5份，决明子2份，牛膝5份，泽泻2份，熟地6份，山药6份，茯苓7份，白术2份，灵芝草4份，陈皮1份，酸枣仁2份，甘草4份；
在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温至90℃，超声1h，过滤得到一次滤渣和一次滤液，取一次滤液用孔径为0.3μm陶瓷膜过滤得到一次透过液，减压干燥得到物料A，其中，混合物和水的重量比为1：20；将物料A溶于水中，加丙酮沉淀，过滤，将滤饼真空干燥得到物料B；向一次滤渣中加入质量分数为60wt％乙醇水溶液，升温至30℃，超声3h，过滤得到二次滤渣和二次滤液，取二次滤液用孔径为0.1μm陶瓷膜过滤得到二次透过液，取二次透过液用分子截留量为4000D超滤膜过滤得到超滤透过液，减压干燥得到物料C，其中，混合物和乙醇水溶液的重量比为1：25；向二次滤渣中加入乙醇，升温至50℃，超声40min，过滤得到三次滤渣和三次滤液，取三次滤液用孔径为0.3μm陶瓷膜过滤得到三次透过液，减压干燥得到物料D，其中，混合物和乙醇的重量比为1：15；将物料D溶于乙醇中，加水沉淀，过滤，将滤饼真空干燥得到物料E；将物料B、物料C、物料E粉碎至300目混匀得到中药提取物。
实施例4
一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 65份，甜菊苷17份，木糖醇5.5份，低聚果糖4.5份，海藻糖4.5份，麦芽糖醇6.5份，中药提取物12份；
其中，中药提取物的原料按重量份包括：枸杞子7份，黄芪4.5份，人参8份，银杏叶3.5份，决明子3.5份，牛膝3.5份，泽泻3.5份，熟地4.5份，山药8份，茯苓5.5份，白术3.5份，灵芝草3.3份，陈皮2.5份，酸枣仁1.3份，甘草5.5份；
在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温至80℃，超声2h，过滤得到一次滤渣和一次滤液，取一次滤液用孔径为0.1μm陶瓷膜过滤得到一次透过液，减压干燥得到物料A，其中，混合物和水的重量比为1：30；将物料A溶于水中，加丙酮沉淀，过滤，将滤饼真空干燥得到物料B；向一次滤渣中加入质量分数为40wt％乙醇水溶液，升温至50℃，超声2h，过滤得到二次滤渣和二次滤液，取二次滤液用孔径为0.3μm陶瓷膜过滤得到二次透过液，取二次透过液用分子截留量为3000D超滤膜过滤得到超滤透过液，减压干燥得到物料C，其中，混合物和乙醇水溶液的重量比为1：35；向二次滤渣中加入乙醇，升温至30℃，超声60min，过滤得到三次滤渣和三次滤液，取三次滤液用孔径为0.1μm陶瓷膜过滤得到三次透过液，减压干燥得到物料D，其中，混合物和乙醇的重量比为1：25；将物料D溶于乙醇中，加水沉淀，过滤，将滤饼真空干燥得到物料E；将物料B、物料C、物料E粉碎至100目混匀得到中药提取物。
实施例5
一种降血压的复配甜味剂，其原料按重量份包括：莱鲍迪苷A 75份，甜菊苷13份，木糖醇6.5份，低聚果糖3.5份，海藻糖5.5份，麦芽糖醇5.5份，中药提取物18份；
其中，中药提取物的原料按重量份包括：枸杞子5份，黄芪5.5份，人参7份，银杏叶4.5份，决明子2.5份，牛膝4.5份，泽泻2.5份，熟地5.5份，山药7份，茯苓6.5份，白术2.5份，灵芝草3.7份，陈皮1.5份，酸枣仁1.7份，甘草4.5份；
在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温至85℃，超声1.5h，过滤得到一次滤渣和一次滤液，取一次滤液用孔径为0.2μm陶瓷膜过滤得到一次透过液，减压干燥得到物料A，其中，混合物和水的重量比为1：25；将物料A溶于水中，加丙酮沉淀，过滤，将滤饼真空干燥得到物料B；向一次滤渣中加入质量分数为50wt％乙醇水溶液，升温至40℃，超声2.5h，过滤得到二次滤渣和二次滤液，取二次滤液用孔径为0.2μm陶瓷膜过滤得到二次透过液，取二次透过液用分子截留量为3000D超滤膜过滤得到超滤透过液，减压干燥得到物料C，其中，混合物和乙醇水溶液的重量比为1：30；向二次滤渣中加入乙醇，升温至40℃，超声50min，过滤得到三次滤渣和三次滤液，取三次滤液用孔径为0.2μm陶瓷膜过滤得到三次透过液，减压干燥得到物料D，其中，混合物和乙醇的重量比为1：20；将物料D溶于乙醇中，加水沉淀，过滤，将滤饼真空干燥得到物料E；将物料B、物料C、物料E粉碎至200目混匀得到中药提取物。
试验例1
随机抽取经检查确定为高血压的患者100例，其中男53例，女47例，年龄48-63岁。将实施例5用水冲服，每8g为一剂，每天两剂，连续服用6个月。治疗结果为：在100例高血压患者中，痊愈79例，有效12例，无效9例，治愈率为79％，总有效率为91％，其中，临床症状全部消失，血压检查正常为痊愈；临床症状基本消失，舒张压和收缩压明显降低为有效；症状无明显改善为无效。
由上述结果可以看出，本发明降血压效果好。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种降血压的复配甜味剂，其特征在于，其原料按重量份包括：莱鲍迪苷A 60-80份，甜菊苷10-20份，木糖醇5-7份，低聚果糖3-5份，海藻糖4-6份，麦芽糖醇5-7份，中药提取物10-20份；
其中，中药提取物的原料包括：枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草。
2.根据权利要求1所述降血压的复配甜味剂，其特征在于，其原料按重量份包括：莱鲍迪苷A 65-75份，甜菊苷13-17份，木糖醇5.5-6.5份，低聚果糖3.5-4.5份，海藻糖4.5-5.5份，麦芽糖醇5.5-6.5份，中药提取物12-18份。
3.根据权利要求1或2所述降血压的复配甜味剂，其特征在于，中药提取物的原料按重量份包括：枸杞子4-8份，黄芪4-6份，人参6-9份，银杏叶3-5份，决明子2-4份，牛膝3-5份，泽泻2-4份，熟地4-6份，山药6-9份，茯苓5-7份，白术2-4份，灵芝草3-4份，陈皮1-3份，酸枣仁1-2份，甘草4-6份。
4.根据权利要求1-3任一项所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温，超声，过滤得到一次滤渣和一次滤液，取一次滤液用陶瓷膜过滤得到一次透过液，减压干燥得到物料A；将物料A纯化得到物料B；向一次滤渣中加入乙醇水溶液，升温，超声，过滤得到二次滤渣和二次滤液，取二次滤液用陶瓷膜过滤得到二次透过液，取二次透过液纯化，减压干燥得到物料C；向二次滤渣中加入乙醇，升温，超声，过滤得到三次滤渣和三次滤液，取三次滤液用陶瓷膜过滤得到三次透过液，减压干燥得到物料D；将物料D纯化得到物料E；将物料B、物料C、物料E粉碎混匀得到中药提取物。
5.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，将枸杞子、黄芪、人参、银杏叶、决明子、牛膝、泽泻、熟地、山药、茯苓、白术、灵芝草、陈皮、酸枣仁、甘草粉碎混匀得到混合物；向混合物中加入水，升温至80-90℃，超声1-2h，过滤得到一次滤渣和一次滤液，取一次滤液用陶瓷膜过滤得到一次透过液，减压干燥得到物料A；将物料A溶于水中，加丙酮沉淀，过滤，将滤饼真空干燥得到物料B；向一次滤渣中加入质量分数为40-60wt％乙醇水溶液，升温至30-50℃，超声2-3h，过滤得到二次滤渣和二次滤液，取二次滤液用陶瓷膜过滤得到二次透过液，取二次透过液用超滤膜过滤得到超滤透过液，减压干燥得到物料C；向二次滤渣中加入乙醇，升温至30-50℃，超声40-60min，过滤得到三次滤渣和三次滤液，取三次滤液用陶瓷膜过滤得到三次透过液，减压干燥得到物料D；将物料D溶于乙醇中，加水沉淀，过滤，将滤饼真空干燥得到物料E；将物料B、物料C、物料E粉碎至100-300目混匀得到中药提取物。
6.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，陶瓷膜的孔径为0.1-0.3μm。
7.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，超滤膜的分子截留量为3000-4000D。
8.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，在物料A中，混合物和水的重量比为1：20-30。
9.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，在物料C中，混合物和乙醇水溶液的重量比为1：25-35。
10.根据权利要求4所述降血压的复配甜味剂，其特征在于，在中药提取物的制备过程中，在物料D中，混合物和乙醇的重量比为1：15-25。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610309782.6A CN105942428A (zh) | 2016-05-10 | 2016-05-10 | 一种降血压的复配甜味剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610309782.6A CN105942428A (zh) | 2016-05-10 | 2016-05-10 | 一种降血压的复配甜味剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105942428A true CN105942428A (zh) | 2016-09-21 |
Family
ID=56912603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610309782.6A Pending CN105942428A (zh) | 2016-05-10 | 2016-05-10 | 一种降血压的复配甜味剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105942428A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111567800A (zh) * | 2020-05-26 | 2020-08-25 | 江苏周春祥生物科技有限公司 | 可替代蔗糖的甜味组合物及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068625A (zh) * | 2010-12-30 | 2011-05-25 | 蚌埠丰原涂山制药有限公司 | 一种降糖降压的中药组合物及其制备方法 |
| CN105053955A (zh) * | 2015-08-14 | 2015-11-18 | 蚌埠市华东生物科技有限公司 | 一种无后苦味降血糖的甜味剂 |
| CN105106592A (zh) * | 2015-08-11 | 2015-12-02 | 蚌埠市华东生物科技有限公司 | 一种中药提取物复配甜味剂 |
| CN105146468A (zh) * | 2015-08-11 | 2015-12-16 | 蚌埠市华东生物科技有限公司 | 一种补气健脾甜菊糖甙复配甜味剂 |
-
2016
- 2016-05-10 CN CN201610309782.6A patent/CN105942428A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068625A (zh) * | 2010-12-30 | 2011-05-25 | 蚌埠丰原涂山制药有限公司 | 一种降糖降压的中药组合物及其制备方法 |
| CN105106592A (zh) * | 2015-08-11 | 2015-12-02 | 蚌埠市华东生物科技有限公司 | 一种中药提取物复配甜味剂 |
| CN105146468A (zh) * | 2015-08-11 | 2015-12-16 | 蚌埠市华东生物科技有限公司 | 一种补气健脾甜菊糖甙复配甜味剂 |
| CN105053955A (zh) * | 2015-08-14 | 2015-11-18 | 蚌埠市华东生物科技有限公司 | 一种无后苦味降血糖的甜味剂 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111567800A (zh) * | 2020-05-26 | 2020-08-25 | 江苏周春祥生物科技有限公司 | 可替代蔗糖的甜味组合物及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104435775A (zh) | 一种中药保健酒及其制备方法 | |
| CN103520621B (zh) | 一种治疗老年性白内障的中药组合物及其制备方法 | |
| CN104225361A (zh) | 一种丹七养生酒及其制备方法 | |
| CN105816788A (zh) | 一种用于治疗小儿消化不良的中药制剂及其制备方法 | |
| CN105435045A (zh) | 一种治疗气血不足症状的药物及其制备方法 | |
| CN104958646A (zh) | 一种润肠通便的中药制剂及其制备方法 | |
| CN104740437A (zh) | 一种治疗便秘的中药组合物及其制备方法 | |
| CN103977206B (zh) | 改善肠胃消化***功能的中药制剂及其生产方法 | |
| CN104547622A (zh) | 一种治疗白内障的中药制剂及其制备方法 | |
| CN104826012A (zh) | 一种用于垂体瘤术后护理的中药制剂及其制备方法 | |
| CN104815294A (zh) | 一种治疗慢性胃炎的中药口服液及其制备方法 | |
| CN104353051A (zh) | 一种治疗胃痛的中药制剂及其制备方法 | |
| CN108576341A (zh) | 一种可改善男性性功能的咖啡及制备方法 | |
| CN105942428A (zh) | 一种降血压的复配甜味剂 | |
| CN104623374A (zh) | 一种治疗急性放射病的中药制剂及其制备方法 | |
| CN105250569A (zh) | 一种用于治疗末梢神经炎的中药丸剂及制备方法 | |
| CN104524479A (zh) | 一种治疗经前期综合征的中药组合物及其制备方法 | |
| CN104906547A (zh) | 一种治疗脾气虚弱型经行泄泻的冲剂及其制备方法 | |
| CN109486628A (zh) | 一种具有增强免疫力、缓解疲劳和改善睡眠功能的保健酒及其制备方法 | |
| CN105998743A (zh) | 一种具有降血压作用的甜味剂 | |
| CN104096073A (zh) | 一种治疗***的中药组合物及其制备方法 | |
| CN103212026A (zh) | 一种治疗胆石症的中药及其制备方法和服用方法 | |
| CN101985005A (zh) | 治疗***的中草药 | |
| CN106214992A (zh) | 一种用于治疗近视的中药配方 | |
| CN106266427A (zh) | 一种治疗肾病的中药药酒及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160921 |