CN105924439A - 一种帕布昔利布的制备方法 - Google Patents
一种帕布昔利布的制备方法 Download PDFInfo
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- CN105924439A CN105924439A CN201610463462.6A CN201610463462A CN105924439A CN 105924439 A CN105924439 A CN 105924439A CN 201610463462 A CN201610463462 A CN 201610463462A CN 105924439 A CN105924439 A CN 105924439A
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- piperazine
- cyclopenta
- base
- amino
- methyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
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CN201610463462.6A CN105924439B (zh) | 2016-06-24 | 2016-06-24 | 一种帕布昔利布的制备方法 |
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CN105924439A true CN105924439A (zh) | 2016-09-07 |
CN105924439B CN105924439B (zh) | 2017-11-24 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017067506A1 (zh) * | 2015-10-22 | 2017-04-27 | 苏州晶云药物科技有限公司 | 帕博西尼的新晶型 |
WO2018065999A1 (en) * | 2016-10-07 | 2018-04-12 | Mylan Laboratories Limited | Novel polymorph of an intermediate for palbociclib synthesis |
CN108017629A (zh) * | 2016-11-04 | 2018-05-11 | 上海奥博生物医药技术有限公司 | 一种帕博西尼无定形态 |
CN108864078A (zh) * | 2017-05-10 | 2018-11-23 | 江苏豪森药业集团有限公司 | 帕博西尼晶型b的制备方法 |
CN112552297A (zh) * | 2020-12-12 | 2021-03-26 | 江西国药有限责任公司 | 一种哌柏西利的制备方法与流程 |
WO2023035667A1 (zh) * | 2021-09-07 | 2023-03-16 | 山东铂源药业股份有限公司 | 一种帕布昔利布的低成本制备方法 |
Citations (5)
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WO2008032157A2 (en) * | 2006-09-08 | 2008-03-20 | Pfizer Products Inc. | Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
WO2014128588A1 (en) * | 2013-02-21 | 2014-08-28 | Pfizer Inc. | Solid forms of a selective cdk4/6 inhibitor |
CN104447739A (zh) * | 2014-11-07 | 2015-03-25 | 郑州泰基鸿诺药物科技有限公司 | 一种氘代Palbociclib衍生物、制备方法及应用 |
WO2016024249A1 (en) * | 2014-08-14 | 2016-02-18 | Sun Pharmaceutical Industries Limited | Crystalline forms of palbociclib |
CN105541832A (zh) * | 2015-12-15 | 2016-05-04 | 南京艾德凯腾生物医药有限责任公司 | 一种羟乙基磺酸盐帕布昔利布的制备方法 |
-
2016
- 2016-06-24 CN CN201610463462.6A patent/CN105924439B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008032157A2 (en) * | 2006-09-08 | 2008-03-20 | Pfizer Products Inc. | Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
WO2014128588A1 (en) * | 2013-02-21 | 2014-08-28 | Pfizer Inc. | Solid forms of a selective cdk4/6 inhibitor |
WO2016024249A1 (en) * | 2014-08-14 | 2016-02-18 | Sun Pharmaceutical Industries Limited | Crystalline forms of palbociclib |
CN104447739A (zh) * | 2014-11-07 | 2015-03-25 | 郑州泰基鸿诺药物科技有限公司 | 一种氘代Palbociclib衍生物、制备方法及应用 |
CN105541832A (zh) * | 2015-12-15 | 2016-05-04 | 南京艾德凯腾生物医药有限责任公司 | 一种羟乙基磺酸盐帕布昔利布的制备方法 |
Non-Patent Citations (4)
Title |
---|
BRIAN P. CHEKAL 等: "Palbociclib Commercial Manufacturing Process Development. Part III. Deprotection Followed by Crystallization for API Particle Property Control", 《ORG. PROCESS RES. DEV.》 * |
MARK T. MALONEY 等: "Palbociclib Commercial Manufacturing Process Development. Part II: Regioselective Heck Coupling with Polymorph Control for Processability", 《ORG. PROCESS RES. DEV.》 * |
SHENGQUAN DUAN 等: "Palbociclib Commercial Manufacturing Process Development. Part I:Control of Regioselectivity in a Grignard-Mediated SNAr Coupling", 《ORG. PROCESS RES. DEV.》 * |
崔艳丽 等: "周期蛋白依赖性激酶4/6 抑制剂palbociclib", 《现代药物与临床》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017067506A1 (zh) * | 2015-10-22 | 2017-04-27 | 苏州晶云药物科技有限公司 | 帕博西尼的新晶型 |
WO2018065999A1 (en) * | 2016-10-07 | 2018-04-12 | Mylan Laboratories Limited | Novel polymorph of an intermediate for palbociclib synthesis |
US10710999B2 (en) | 2016-10-07 | 2020-07-14 | Mylan Laboratories Limited | Polymorph of an intermediate for palbociclib synthesis |
CN108017629A (zh) * | 2016-11-04 | 2018-05-11 | 上海奥博生物医药技术有限公司 | 一种帕博西尼无定形态 |
CN108864078A (zh) * | 2017-05-10 | 2018-11-23 | 江苏豪森药业集团有限公司 | 帕博西尼晶型b的制备方法 |
CN108864078B (zh) * | 2017-05-10 | 2021-10-15 | 江苏豪森药业集团有限公司 | 帕博西尼晶型b的制备方法 |
CN112552297A (zh) * | 2020-12-12 | 2021-03-26 | 江西国药有限责任公司 | 一种哌柏西利的制备方法与流程 |
WO2023035667A1 (zh) * | 2021-09-07 | 2023-03-16 | 山东铂源药业股份有限公司 | 一种帕布昔利布的低成本制备方法 |
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