CN105902857A - Astragalus membranaceus, corn stigma and wolfberry fruit hypoglycemic oral liquid and preparation method thereof - Google Patents
Astragalus membranaceus, corn stigma and wolfberry fruit hypoglycemic oral liquid and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an astragalus membranaceus, corn stigma and wolfberry fruit hypoglycemic oral liquid and a preparation method thereof. With the following traditional Chinese medicinal materials, astragalus membranaceus, corn stigma and wolfberry fruits, with the hypoglycemic function as raw materials, the medicinal comprehensive functions of active ingredients, namely astragalus polysaccharide, corn stigma total saponins, lycium barbarum polysaccharide and flavonoid of the medicinal materials are utilized, so that the hypoglycemic target is relatively effectively achieved; and meanwhile, complications of diabetes mellitus patients are prevented or delayed. The hypoglycemic oral liquid has the efficacies of nourishing yin, tonifying yang, protecting the liver and gallbladder, improving eyesight, reducing blood pressure and delaying senescence, and is especially suitable for middle-aged and aged people. The hypoglycemic health oral liquid has the characteristics of being safe, convenient, free of a toxic or side effect, low in price, convenient to take and the like; the preparation method is simple; and the oral liquid is suitable for large-scale production.
Description
Technical field
The present invention relates to a kind of hypoglycemic health care oral liquid and preparation method thereof, be to carry out health product with function of reducing blood sugar with the Chinese medicine Radix Astragali corn stigma fruit of Chinese wolfberry for raw material, be particularly suitable for mid-aged population and take.
Background technology
Diabetes: it is by the metabolic disease caused by h and E factor interaction, lack due to insulin secretion and (or) its biological agent obstacle causes carbohydrate metabolism disturbance, simultaneously with the dysbolism of fat, protein, water, electrolyte etc., with chronic hyperglycemia as principal character.Belonging to " diabete " category in traditional Chinese medicine, principal character is to be become thin by the thirsty gluttony caused by lung, stomach, the scorching deficiency of Yin of kidney, frequent micturition turbid urine, body.Diabetes are a kind of chronic lifelong participation diseases, and its illness rate rises the most year by year, have become the third-largest NCD after developed country's relaying cardiovascular disease and tumour.Diabetes mellitus in China illness rate is increased to 2.5% by original 1%.Therefore, diabetes and complication thereof have become the worldwide public health problem of serious threat human health.In terms of its treatment, Western medicine blood sugar reducing function highlights, but has certain limitation and bad reaction, as caused hypoglycemia, lactic acidosis etc..And plant component, the traditional Chinese medicine ingredients such as plant polyose and saponin(e that particularly traditional Chinese medical science is conventional, not only toxic and side effect is little, and a lot of medicine has reducing blood lipid, regulation endocrine simultaneously, improves the effects such as immunity, also has good preventive and therapeutic action to diabetic complication.Therefore, excavate from natural products medicinal plant (Chinese herbal medicine) and exploitation can the hypoglycemic oral liquid of the most hypoglycemic taking convenience that can improve again immunity of organisms have great importance and wide market application foreground.
The Radix Astragali: pulse family perennial herb, part of being used as medicine is for being dried root.Nature and flavor: sweet, tepor.The Radix Astragali is conventional bulk medicinal materials, begins to be loaded in Shennong's Herbal, has invigorating qi for strengthening superficies, diuresis detumescence, effect of promoting pus discharge and tissue regeneration, be widely used in clinical departments, have the title of " ten medicine eight stilbenes ".The medicinal history having more than 2000 year so far of the Radix Astragali, main active is astragalus polyose, triterpene, flavonoids etc..The Radix Astragali has important function at immunological regulation, antitumor, antiviral, diabetes, the aspect such as delay senility.The prescription statistical analysis treating diabetes at all times finds that the applying frequency of the Radix Astragali is the highest.Compatibility Chinese yam, the fruit of Chinese wolfberry, the wind-weed, root of Chinese trichosanthes, hypoglycemic, glucose in urine is evident in efficacy, it is adaptable to diabetes are partial to weakness of the spleen and the stomach and insufficiency of lung-QI,deficiency of lung-QI person.
Corn stigma: it is grass maize Zea may
L. dry style and column cap, typically in harvest corn browning in season and withered time gather.Property flat, taste is sweet, have no side effect, can be eaten for a long time.Containing the multiple chemical composition useful to human body in corn stigma, such as polysaccharide, alkaloids, flavonoids, saponins, sterols, volatile materials, amino acid, trace element and multivitamin etc., have diuresis, detumescence, heat-clearing, hypoglycemic, hypotensive, strengthen the effects such as immune, anticancer.Research finds that corn stigma Total saponin is the chief active position reducing diabetes patient blood sugar.Additionally possibly together with chromium in corn stigma, chromium is the part of the sugar tolerance factor, can strengthen insulin function.In corn stigma, the content of Flavonoid substances is 15 times of iblet, it can reduce the generation of free radical and remove free radical, there is good oxidation resistance, and the ability of corn silk water extract removing free radical is higher than isoflavones, can prevent diabetic complication.
The fruit of Chinese wolfberry: the ripening fruits of matrimony vine of solanaceae plant, nature and flavor are sweet, flat.Mainly contain LBP-X and the big active component of flavonoids two, additionally contain multivitamin and amino acid and the composition such as carrotene, luteole, have nourishing liver and kidney, benefiting shrewd head, promote the production of body fluid to quench thirst, effect of tonifying both YIN and YANG, also can hypotensive, hypoglycemic, reducing blood lipid, antitumor, improve body immunity and delay senility, it it is a kind of tradition invigorant, fatty liver and diabetic are had certain curative effect, enjoys a very good reputation in China and other areas, Asia.
One aspect of the present invention basis based on China's Traditional Chinese Medicine dialectical theory on treatment diabetes, these symptoms of the problems, particularly middle and elderly diabetic people such as the hypoimmunity that another aspect generally exists for the elderly's healths, the positive liter deficiency of Yin, insomnia fatigue, sexuality decline, aging acceleration are especially prominent.Select the Chinese medicine Radix Astragali, corn stigma and the fruit of Chinese wolfberry with hypoglycemic activity repeatedly proved through the traditional Chinese medical science as raw material, the main active of the Radix Astragali is astragalus polyose and astragaloside, the main active of corn stigma is Stigma Maydis total saponins and polysaccharide, and the main active of the fruit of Chinese wolfberry is LBP-X, glycine betaine and flavonoids.Have compared with the hypoglycemic medicament that this oral liquid is conventional with on market effect stability, curative effect persistently, no dependence, the feature such as have no side effect.Blood sugar can be reduced, moreover it is possible to improve immunity, reduce blood pressure, build up health, delay senility, antifatigue and raising sexuality, be particularly suitable for the person in middle and old age white collar crowd that operating pressure is bigger.
Although this oral liquid has good hypoglycemic and nourishing function, but the most not is suitable for taking to everyone, more can not excess.Due to the Radix Astragali and matrimony vine, to warm the effect of health quite strong, is cautious use of for just patient in cat fever or diarrhoea, is best suitable for having a delicate constitution, the diabetic of resistance difference and consumer, long-term taking result for the treatment of more preferably, and the generation of delaying complications of diabetes.This product is concentrate, substantially increases the activity component concentration of medicinal material, uses degerming packing simultaneously, light and air are had good buffer action, is avoided that the degraded of effective active composition is gone bad, and easily stored carries, it is simple to consumer's accurate quantification is taken.Can in, dinner drink a pipe oral liquid after half an hour, can play treatment metabolic disorder effect, moreover it is possible to promote digestion and absorb, strengthen health care.
Summary of the invention
An object of the present invention is to utilize the comprehensive pharmacological function of the effective active composition of the Radix Astragali, corn stigma, the fruit of Chinese wolfberry, thering is provided the most hypoglycemic health care oral liquid of one, formula is reasonable, taking convenience, comprehensive treating diabetes, and prevent or delay the generation of its complication.Simultaneously nourishing and strengthening vital, protect liver and gall improving eyesight, the hypotensive and aspect such as delay senility has remarkable efficacy.This hypoglycemic oral liquor is easy, safety non-toxic, and cheap, each step from raw material to product is quality controllable, is suitable for large-scale production.
The two of the purpose of the present invention are to provide the preparation method of a kind of effective Hyperglycemic health care oral liquid, simple, it is simple to operation.Use degerming packing, it is to avoid the degraded of active component and the use of preservative, fully belong to green product.
To achieve these goals, the present invention takes techniques below measure:
A kind of Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry, its raw material percentage by weight of dry powder proportioning is as follows: the Radix Astragali 18 22%, corn stigma 45 55%, the fruit of Chinese wolfberry 28 35%.
A kind of Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry, the optimal proportion of its raw material percentage by weight of dry powder is as follows: the Radix Astragali 20%, corn stigma 50%, the fruit of Chinese wolfberry 30%.
The preparation method of a kind of Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry, comprises the following steps that
(1) gather artificial growth 3 years raw astragalus mongolicus (Astragalus membranaceu), cutting off aerial part, clean root is exposed to the sun under the sun 10 15 days or 50 60 DEG C and dries 57 days to being crushed into powder；
(2) the corn maturity period plucks withered corn stigma and is exposed to the sun under the sun 13 days or 60 70 DEG C and dries 5 10 hours to can crushed into powder；
(3) the sub drying in 7 10 days or 50 60 DEG C of being exposed to the sun under the sun of the lycium barbarum of harvesting ripe 35 days extremely can be with crushed into powder；
(4) Radix Astragali, corn stigma and the fruit of Chinese wolfberry rate by weight percentage mixing dried in step (1), (2), (3), is ground into powder with pulverizer, obtains the mixing meal of moisture≤5%；
(5) the mixing meal of step (4) is joined in the nozzle of impact grinder, it is made to be ejected in grinder with the speed of 75 110 m/s, control grinding built-in temperature is at 35 45 DEG C, and attrition grinding 23 hours, obtaining fineness is the 200 600 ultra-fine mixed-powders of purpose；
Abrasive body in described grinder is ceramic material, it is possible to ensure that the crushing process of the Radix Astragali corn stigma fruit of Chinese wolfberry does not introduce any metal ingredient；
(6) by the ultra-fine mixed-powder of step (5) and pure water by solid-liquid ratio 1:10(gram: milliliter) soak 12 hours, 40 60 DEG C of thermostatic ultrasonics extractions, refluxing extraction in triplicate, each 35 hours, by filtrate centrifuge after filtration；Concentrated by Rotary Evaporators rotary evaporation again, temperature be less than 60 DEG C, obtain solid-liquid ratio and be 2:1(gram: milliliter) concentrate；
Preferably, described temperature is 45 55 DEG C, most preferably 50 DEG C；Described extraction time is 3.5 4.5 hours, most preferably 4 hours；
(7) the concentrate filter membrane by step (6) degerming, packing, obtain the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry.
The present invention'sStorage practice:Owing to the active component of autonomic drug has degraded or sex change under ultraviolet and high temperature long term, therefore it is noted that avoid the effect of short wavelength light and high temperature in production, storage process, preferably use filter membrane degerming and brown environmental protection vial dispenses.
The using method of the present invention: capable of direct drinking or 50 DEG C of warm boiled waters.
Advantages of the present invention and beneficial effect:
、The present invention has that preparation method is simple, taking convenience, cheap feature.
、The present invention is suitable to large-scale production.
、The clinical drug of the present invention uses result to show: utilize the comprehensive function at the Radix Astragali, corn stigma, the fruit of Chinese wolfberry hypoglycemic chief active position to reduce blood sugar, reduce hypoglycemic effect than the extract being manufactured separately with three kinds of medicinal materials notable much, be diabetic's hypoglycemic health-care good product of particularly patients with NIDDM.Showing to be had no any toxic reaction by experimental animal mouse through animal acute toxicity experiment, its main organs is also without significantly changing, and safety of medicine is reliable, has no side effect.
、The present invention follows the principle of tcm syndrome differentiation and treatment, all medicine phases and, wherein rich in plant polyose, flavonoids, saponin(e, vitamin, amino acid and various trace elements etc., it is beneficial to absorption of human body, there is nourishing and strengthening vital, improve immunity, delay senility, constitutional effect.
Detailed description of the invention
In order to the present invention is better described, it is simple to understand technical scheme, the typical but non-limiting embodiment of the present invention is as follows:
Test example
1
:
A kind of preparation of the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry:
(1) gather 3 years raw astragalus mongolicus of artificial growth, cut off aerial part, clean root and dry 5 days in 60 DEG C and be crushed into powder to being prone to；
(2) corn stigma that the harvesting of corn maturity period is withered 5 hours extremely can crushed into powder in 70 DEG C of drying；
(3) lycium barbarum of harvesting ripe dries 5 days to using crushed into powder in 50 DEG C；
(4) Radix Astragali, corn stigma and the fruit of Chinese wolfberry dried in step (1), (2), (3) rate 25%, 40%, 35% mixed powder by weight percentage is broken into powder, obtains the mixing meal of moisture≤5%；
(5) the mixing meal of step (4) is joined in the nozzle of impact grinder so that it is with 80
The speed of m/s is ejected in grinder, and control grinding built-in temperature is at 35 DEG C, and attrition grinding 2.0 hours, obtaining fineness is the 300 ultra-fine mixed-powders of purpose；
(6) by the ultra-fine mixed-powder of step (5) and pure water by solid-liquid ratio 1:10(gram: milliliter) soak 12 hours, 45 DEG C of thermostatic ultrasonics extractions, refluxing extraction in triplicate, each 3.5 hours, by filtrate centrifuge after filtration；Concentrated by Rotary Evaporators rotary evaporation again, temperature be less than 60 DEG C, obtain solid-liquid ratio and be 2:1(gram: milliliter) concentrate；
(7) the solution filter membrane after step (6) being concentrated is degerming, packing, obtains the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry.
Test example
2
:
A kind of preparation of the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry:
(1) gather 3 years raw astragalus mongolicus of artificial growth, cut off aerial part, clean root and dry 7 days in 50 DEG C and be crushed into powder to being prone to；
(2) corn stigma that the harvesting of corn maturity period is withered 8 hours extremely can crushed into powder in 70 DEG C of drying；
(3) lycium barbarum of harvesting ripe dries 3 days to using crushed into powder in 60 DEG C；
(4) Radix Astragali, corn stigma and the fruit of Chinese wolfberry dried in step (1), (2), (3) rate 20%, 50%, 30% mixed powder by weight percentage is broken into powder, obtains the mixing meal of moisture≤5%；
(5) being joined by the mixing meal of step (4) in the nozzle of impact grinder so that it is be ejected in grinder with the speed of 95m/s, control grinding built-in temperature is at 40 DEG C, and attrition grinding 2.5 hours, obtaining fineness is the 400 ultra-fine mixed-powders of purpose；
(6) by the ultra-fine mixed-powder of step (5) and pure water by solid-liquid ratio 1:10(gram: milliliter) soak 12 hours, 50 DEG C of thermostatic ultrasonics extractions, refluxing extraction in triplicate, each 4 hours, by filtrate centrifuge after filtration；Concentrated by Rotary Evaporators rotary evaporation again, temperature be less than 60 DEG C, obtain solid-liquid ratio and be 2:1(gram: milliliter) concentrate；
(7) the solution filter membrane after step (6) being concentrated is degerming, packing, obtains the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry.
Test example
3
:
A kind of preparation of the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry:
(1) gather 3 years raw astragalus mongolicus of artificial growth, cut off aerial part, clean root and dry 7 days in 50 DEG C and be crushed into powder to being prone to；
(2) corn stigma that the harvesting of corn maturity period is withered 10 hours extremely can crushed into powder in 60 DEG C of drying；
(3) lycium barbarum of harvesting ripe dries 5 days to using crushed into powder in 60 DEG C；
(4) Radix Astragali, corn stigma and the fruit of Chinese wolfberry dried in step (1), (2), (3) rate 18%, 54%, 28% mixed powder by weight percentage is broken into powder, obtains the mixing meal of moisture≤5%；
(5) the mixing meal of step (4) is joined in the nozzle of impact grinder so that it is with 110
The speed of m/s is ejected in grinder, and control grinding built-in temperature is at 45 DEG C, and attrition grinding 3 hours, obtaining fineness is the 600 ultra-fine mixed-powders of purpose；
(6) by the ultra-fine mixed-powder of step (5) and pure water by solid-liquid ratio 1:10(gram: milliliter) soak 12 hours, 55 DEG C of thermostatic ultrasonics extractions, refluxing extraction in triplicate, each 5 hours, by filtrate centrifuge after filtration；Concentrated by Rotary Evaporators rotary evaporation again, temperature be less than 60 DEG C, obtain solid-liquid ratio and be 2:1(gram: milliliter) concentrate；
(7) the solution filter membrane after step (6) being concentrated is degerming, packing, obtains the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry.
Test example
4
:
A kind of test of pesticide effectiveness of the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry
In order to verify that the present invention is more notable than the effect of lowering blood sugar effect of three kinds of independent extracts of equivalent medicinal material, recruit 50-65 year grow up patients with NIDDM 40 people (fasting blood-glucose > 7.0 mmol/L and 2 hours blood glucose after the meal > 11.0 mmol/L), it is assigned randomly to individually take the Radix Astragali group of Radix Astragali extractive solution, individually take the corn stigma group of corn stigma extract, the matrimony vine subgroup individually taking medlar extract liquid and this oral liquid group, often organizes 10 people.Within after often organizing continuous lunch, dinner 2 hours, take in an effective independent medicinal material or the present invention three kinds of medicinal material optimal proportion combinations and 15ml extract prepared by optimum extracting method, continuous 30 days.Fasting blood-glucose and the postprandial blood sugar of experimenter is measured after 30 days.
Result shows: Radix Astragali group diabetic's fasting blood-glucose and postprandial blood sugar decline 2.42 ± 0.54 mmol/L and 3.95 ± 0.78 mmol/L respectively；Corn stigma group diabetic's fasting blood-glucose and postprandial blood sugar decline 4.14 ± 0.63 mmol/L and 6.48 ± 0.72 mmol/L respectively；Matrimony vine subgroup diabetic's fasting blood-glucose and postprandial blood sugar decline 1.83 ± 0.39 mmol/L and 3.72 ± 0.46 mmol/L respectively；This oral liquid group diabetic's fasting blood-glucose and postprandial blood sugar decline 7.06 ± 1.15 mmol/L and 9.22 ± 1.37 mmol/L respectively.
Claims (3)
1. the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry, it is characterised in that it is made up of the raw material dry powder of following weight proportioning: the Radix Astragali 18 22%, corn stigma 45 55%, the fruit of Chinese wolfberry 28 35%.
2. the preparation method of the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry, it is characterised in that comprise the steps:
(1) gather 3 years raw astragalus mongolicus of artificial growth, cut off aerial part, clean root be exposed to the sun under the sun 10 15 days or 50 60 DEG C dry 57 days to being crushed into powder, standby；
(2) the corn maturity period pluck withered corn stigma be exposed to the sun under the sun 13 days or 60 70 DEG C dry 5 10 hours to can crushed into powder, standby；
(3) lycium barbarum of harvesting ripe is exposed to the sun 7 10 days or 50 60 DEG C to dry 35 days under the sun and extremely can crumb into powder with finger, standby；
(4) Milkvetch Root, Corn Stigma and fruit of Chinese wolfberry powder that step (1), (2), (3) prepare being mixed by weight percentage, pulverizer is pulverized, and obtains mixing meal；
(5) the mixing meal of step (4) is joined in the nozzle of impact grinder, it is made to be ejected in grinder with the speed of 75 110 m/s, control grinding built-in temperature is at 35 45 DEG C, and attrition grinding 23 hours, obtaining fineness is the 200 600 ultra-fine mixed-powders of purpose；
(6) the ultra-fine mixed-powder of step (5) and pure water are pressed solid-liquid ratio 1:10 to soak 12 hours；40 60 DEG C of thermostatic ultrasonics extract, refluxing extraction in triplicate, each 35 hours, by filtrate centrifuge after filtration；Concentrated by Rotary Evaporators rotary evaporation again, obtain the concentrate that solid-liquid ratio is 2:1；
(7) the concentrate filter membrane by step (6) degerming, packing, obtain the Radix Astragali hypoglycemic oral liquid of the corn stigma fruit of Chinese wolfberry.
Preparation method the most according to claim 2, it is characterised in that: in described step (6), rotary evaporation thickening temperature is less than 60 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109452646A (en) * | 2018-10-26 | 2019-03-12 | 内蒙古中健宝生物科技有限公司 | A kind of Radix Astragali water and preparation method thereof |
| CN112205554A (en) * | 2020-10-27 | 2021-01-12 | 贵州百科薏仁生物科技有限公司 | Polypeptide instant drink with blood sugar reducing function and preparation method thereof |
| CN115399419A (en) * | 2022-09-02 | 2022-11-29 | 赵利胜 | A beverage prepared from plant extractive solution, and its preparation method |
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| CN104857334A (en) * | 2015-05-13 | 2015-08-26 | 卞佳林 | Hypoglycemic wine and preparation method thereof |
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