CN105902660A - Pharmaceutical composition for treating bedsores, diabetic feet and eczema - Google Patents
Pharmaceutical composition for treating bedsores, diabetic feet and eczema Download PDFInfo
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- CN105902660A CN105902660A CN201610423943.4A CN201610423943A CN105902660A CN 105902660 A CN105902660 A CN 105902660A CN 201610423943 A CN201610423943 A CN 201610423943A CN 105902660 A CN105902660 A CN 105902660A
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Abstract
The invention discloses a pharmaceutical composition for treating bedsores, diabetic feet and eczema. The pharmaceutical composition is prepared from, by weight, 14-16 parts of rhizoma coptidis, 14-16 parts of radix scutellariae, 14-16 parts of cortex phellodendri, 11-13 parts of borneol, 14-16 parts of Chinese gall, 11-13 parts of fructus cnidii, 11-13 parts of fructus kochiae, 16-20 parts of cortex dictamni, 14-16 parts of radix sophorae flavescentis, 11-13 parts of radix sanguisorbae, 11-13 parts of flos sophorae, 11-13 parts of folium artemisiae argyi, 11-13 parts of herbal menthae and 14-16 parts of pericarpium granati. The defects of existing medicine for treating bedsores, diabetic feet and eczema are overcome, and the pharmaceutical composition has a good treatment effect on bedsores, diabetic feet and eczema.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to one and treat decubital ulcer, diabetic foot and eczema
Pharmaceutical composition.
Background technology
Decubital ulcer, also known as pressure ulcer, pressure ulcer, be due to the long-term pressurized of local organization, occurs to continue
Ischemia, anoxia, malnutrition and to cause tissue fester downright bad.Pressure ulcer is in rehabilitation, nursing
It it is the problem of a universality.According to relevant document, there are about 60,000 people every year and die from pressure ulcer concomitant symptoms.
The cause of disease: 1. pressure factor: (1) pressure at right angle causes the topmost reason of pressure ulcer to be that local organization suffers
Persistence pressure at right angle, especially at health bone tuberosity protrusion.If long-term bed or wheelchair,
Clamping plate inner liner place in improper, Gypsum Fibrosum out-of-flatness or have debris, local bear for a long time exceed normal
The compressing of blood capillary, all can cause the pressure ulcer (pressure that generally speaking blood vessel under skin layer can bear
Be about about 32mmHg, if exceeding above pressure, local vascular just may distortion, deformation and
Have influence on passing through of blood flow, then have the phenomenon of ischemia).(2) frictional force, frictional force acts on skin,
Easily damage the horny layer of skin.When patient is movable in bed or during wheelchair, skin can by sheet and
The retrograde resistance friction on wheelchair cushion surface, after being scratched such as skin by antiperspirant, urinate, the dipping of stool etc.
Time, easily there is pressure ulcer.(3) shearing what is called shearing is to result in after an active force imposes on object
One parallel reciprocal planar slide, is to be added with pressure at right angle by frictional force to form.It closes with position
Closely, such as flat health when raising the head of a bed that crouches glides, and skin parallel frictional force occurs with bed in system,
Plus the gravity of skin vertical direction, thus cause the generation of shearing, cause local skin blood circulation
Obstacle and there is pressure ulcer.2. nutriture: nutrition of whole body lacks, amyotrophy, lacks at pressurized and protects
Protect, such as long-term fever and cachexia etc..Nutrition of whole body obstacle, nutrition intake is not enough, protein occurs
Synthesis minimizing, negative nitrogen balance, subcutaneous fat minimizing, amyotrophy, once pressurized, skin at bone knuckle
Extruding force to skin at skin ambient pressure to be born and bone knuckle, lacks muscle and fat group at pressurized
The protection knitted, causes disturbance of blood circulation pressure ulcer occur.3. skin resistance reduces, and skin is often subject to
The physical properties such as humidity, friction stimulate (such as plaster bandage and clamping plate improper use, gatism, bed
Chip etc. is had on single gauffer injustice, bed), make skin resistance reduce.Treatment: pressure ulcer skin in early days
Rubescent, take to stand up, can take a turn for the better after the measure such as decompression.When skin occurs that shallow table festers, ulcer, oozes
Go out liquid many time just should arrive hospital for treatment in time.1. Drug therapy.2. physiotherapy.3. outside Chinese medicine
Use therapy.4. surgical operation.
Diabetic foot is diabetics because peripheral neuropathy merges too high with peripheral blood vessel
Mechanical pressure, can cause foot soft tissue and the destruction of osteoarticular system and teratogenesis, and then cause
A series of foot problems, from slight nervous symptoms to serious ulcer, infection, angiopathy,
Charcot arthrosis and Neuropathic fracture.The cause of disease: 1. ulcer, a lot of foots of diabetics
Portion's complication rises from sensualness neuropathy and slight autonomous and nervus motorius pathological changes.Wherein feel god
Merge too high mechanical stress through pathological changes, be the main initiating agent causing foot ulcers and infection.Scorching
Disease and histologic lesion are that a certain degree of alternate stress acts on a region specifically lost sensibility
Result.From ground, shoes or other cause ulcer adjacent to pressure or the shearing force of toes,
Owing to lacking normal Neuroprotective Mechanisms, ulcer often increases the weight of because of the existence of apophysis.Autonomic nervous system
The pathological changes of system causes skin normally to perspire regulatory function, skin temperature regulatory function and blood fortune regulating power
Lose, cause local organization reduction of pliability, form thick callus and more broken and cracking.This
Outward, the forfeiture normally perspiring ability has blocked the rehydration of local organization, causes tissue to destroy further,
Deep tissue is made to be easier to bacteria planting.Nervus motorius pathological changes also functions in the morbidity of diabetic foot
Certain effect, the contracture of the inherent flesh of foot causes typical claw toe deformity.The hyperextension of metatarsophalangeal joints is also
It is proved to be able to directly increase head of metatarsal bone downforce so that this position is more likely formed ulcer.Close between nearly toe
Joint flexing causes the interphalangeal joint dorsal part of projection to increase with the ulcerated risk in toe point sole of the foot side, and blood vessel
Pathological changes makes again the tissue destroyed be difficult to heal.2. infecting, dysautonomia causes skin soft
Disorganization, causes outer derived bacterium to invade.Chemotaxis change causes leukocytoreaction inefficiency.
Additionally, hyperglycemia, decrease in oxygen partial pressure and malnutrition etc. can cause tissue edema, acid to gather jointly,
Height blends poor efficiency anaerobic metabolism.This type of environment is suitable for bacterial growth, and hinders the function of leukocyte.
Additionally, angiopathy can cause antibiotic transport limited, further result in antibacterial elimination efficiency and reduce,
Local soft tissue is caused to infect, the most myelitic formation.3.Charcot arthrosis, for gradual
Weight-bearing joints destructiveness pathological changes.Traumatic nerve injury theory is thought, loses the pain sensation and somesthetic sensibility back foot part
Suffer mechanical damage repeatedly or the wound of single-shot can cause Charcot arthropathy;Neural blood vessel
Theory is thought, the lesion region blood supply increase that autonomic nervous dysfunction causes causes bone absorption with strong
Degree weakens, and then, wound repeatedly causes osteoclasia with unstable.4. toes deformity, nervus motorius
Pathological changes causes the contracture of the inherent flesh of foot, causes typical claw toe deformity.If active treatment can not fill
Decompose symptom and complication that certainly lower limb occur, then can cause catastrophic consequence.
Eczema, is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor.Divide anxious
Property, three phases subacute, chronic.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plump.Some
Patient directly translates into chronic eczema.Skin lesion has pleomorphism, symmetry, pruritus and easy recurrent exerbation
Etc. feature.The cause of disease, eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill is the chronicest to disappear
Change systemic disease, psychentonia, insomnia, fatigue, emotion changes, endocrine disturbance, infection,
Dysbolisms etc., exopathogenic factor such as living environment, climate change, food etc. all can affect sending out of eczema
Raw.Environmental stimuli such as daylight, cold, be dried, hot, hot water is scalded and various animal skin,
Plant, cosmetics, soap, staple fibre etc. all can induce.Be the complicated inside and outside factor cause one
Plant delayed allergy.Clinical manifestation, is 1. divided into acute, subacute, chronic three by skin lesion performance
Phase.(1) at the beginning of acute eczema skin lesion it is the most intensive pimple of foxtail millet grain size, papulovesicle or little water
Bleb, substrate flushing, gradually merge in flakes, owing to scratching, pimple, papulovesicle or vesicle top are scratched
Ooze out in obvious point-like afterwards and little rotten to the corn face, blur margin.Such as secondary infection, inflammation becomes apparent from,
Pustule, pus crusts, folliculitis, furuncle etc. can be formed.Conscious violent pruritus.After being apt to occur in head, ear,
Distal limbs, scrotum, crissum etc., many symmetrical issues.(2) subacute eczema acute eczema inflammation
After alleviating, skin lesion based on little pimple, incrustation and squama, rarely seen a small amount of papulovesicle and erosion.Still have
Acutely pruritus.(3) chronic eczema does not often more transfer to slow because of acute, subacute eczema recurrent exerbation
Property eczema;Also can start to be chronic eczema.Show as illing skin to thicken, infiltrate, brownish red or
Pigmentation, rough surface, covers squama, or forms a scab because scratching.Conscious acute pruritus.It is common in
Shank, hands, foot, the fossa cubitalis, nest, pudendum, anus etc..The course of disease is indefinite, easily recurs, prolonged
Do not heal.2. the scope involved according to skin lesion, is divided into limitation eczema and the big class of universal eczema two.(1)
Limitation eczema occurs over just specific part, i.e. can name with position, as wet in hand eczema, cysthus
Rash, eczema scrotum, ear eczema, breast eczema, anal eczema, legs eczema etc..(2) general
Property eczema skin lesion is many, general or distribute in the multiple position of whole body.Such as coin eczema, autosensitization
Property eczema, weary lipid eczema.
Therefore, research will have important meaning for the Chinese medicine of decubital ulcer, diabetic foot and eczema.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing treatment decubital ulcer, diabetic foot and eczema medicine
Deficiency, it is provided that one treats decubital ulcer, diabetic foot and the preferable pharmaceutical composition of eczema effect.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries
, it is made up of the crude drug of following weight parts:
Rhizoma Coptidis 14-16 part, Radix Scutellariae 14-16 part, Cortex Phellodendri 14-16 part, Borneolum Syntheticum 11-13 part, five times
Sub-14-16 part, Fructus Cnidii 11-13 part, Fructus Kochiae 11-13 part, Cortex Dictamni 16-20 part, Radix Sophorae Flavescentis
14-16 part, Radix Sanguisorbae 11-13 part, Flos Sophorae 11-13 part, Folium Artemisiae Argyi 11-13 part, Herba Menthae 11-13 part,
Pericarpium Granati 14-16 part.
Preferably, it is made up of the crude drug of following weight parts:
Rhizoma Coptidis 15 parts, Radix Scutellariae 15 parts, Cortex Phellodendri 15 parts, Borneolum Syntheticum 12 parts, Galla Chinensis 15 parts, Serpentis
Machine tool 12 parts, the Fructus Kochiae 12 parts, Cortex Dictamni 18 parts, Radix Sophorae Flavescentis 15 parts, Radix Sanguisorbae 12 parts, Flos Sophorae
12 parts, Folium Artemisiae Argyi 12 parts, Herba Menthae 12 parts, Pericarpium Granati 15 parts.
The dosage form of pharmaceutical composition of the present invention can be the medical science such as washing liquid, liniment, capsule, tablet
Upper acceptable dosage form, their preparation method, supplementary product consumption are carried out by existing common process.
Pharmaceutical composition of the present invention is prepared the most in accordance with the following methods: Fructus Cnidii, Herba Menthae, Folium Artemisiae Argyi
Chopping, extracts volatile oil with vapor distillation method, and it is standby that the another device of volatile oil seals cold preservation, medicinal residues;Medicinal residues
Add 5-10 times of soak by water 2 times, each 1-2 hour with deicing off-chip ten taste such as remaining Rhizoma Coptidis, merge
Decocting liquid filters, dense, lets cool between relative density 1.03-1.10, adds waving of Borneolum Syntheticum and extraction
Hair oil, 5% ethyl hydroxybenzoate, stirring filters after staticly settling 72 hours, filtrate subpackage, packs, examines
Test, and get final product.
Present invention additionally comprises aforementioned pharmaceutical compositions at preparation treatment decubital ulcer, diabetic foot and the medicine of eczema
Application in thing.
In pharmaceutical composition side of the present invention, share with Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, have heat-clearing and toxic substances removing,
Antibacterial hemostasia effect, is the principal agent for we;Borneolum Syntheticum, Galla Chinensis heat-clearing and toxic substances removing, anticorrosion convergence granulation promoting;
Fructus Cnidii, the Fructus Kochiae, Cortex Dictamni, Radix Sophorae Flavescentis, Radix Sanguisorbae, Flos Sophorae, Folium Artemisiae Argyi, Herba Menthae, Pericarpium Granati etc. close
With, there is dampness removing to stop itchin, the merit of expelling pus and promoting granulation, auxiliary principal agent is with disease of curing the disease, therefore is we's accessory drugss.
Rhizoma Coptidis, bitter cold, there is heat clearing and damp drying, the merit of eliminating fire and detoxication, as " pearl sac ": " ...
All skin ulcers must be used ... ".And modern medicine study confirms, has the antibacterial action of wide spectrum.Therefore we
In play a major role, elect monarch drug as.
Radix Scutellariae, bitter cold, there is a heat clearing and damp drying, eliminating fire and detoxication, cooling blood for hemostasis, the effect that heat extraction is antiabortive, as
" herbal classic ": " ..., malignant boil cellulitis erosion acute scleritis ".Radix Scutellariae decoct has wider antimicrobial spectrum in vitro, and
And Drug resistance is low, to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli,
Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus (a, β), Diplococcus pneumoniae,
Diphtheria corynebacteriums etc. have inhibitory action.With Rhizoma Coptidis compatibility, it is all monarch drug.
Cortex Phellodendri, bitter cold, there are heat clearing and damp drying, eliminating fire and detoxication, bring down a fever except the effect of steaming, such as " herbal classic ":
" all heat in main five internal organs the intestines and stomach ... acute vulva ulcer ".Modern medicine study shows: it is to golden yellow
Staphylococcus, Hemolytic streptococcus, some dermatophytes all have obvious inhibiting effect.Rhizoma Coptidis, Radix Scutellariae
Joining Cortex Phellodendri, mutual reinforcement between is use, for ministerial drug.
Borneolum Syntheticum, acrid in the mouth, hardship, it is slightly cold;Have refreshment of having one's ideas straightened out, heat clearing away dissipates poison pain relieving, improving acuity of vision and removing nebula
Effect, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, and heat-damp in summer blinds clear key, and sore throat is deaf, mouth
Skin ulcer tooth swells, carbuncle sore infantile malnutrition, does not holds back, " medical center bun want " after bursting: " Borneolum Syntheticum master dissipates stagnated fire, can deep heat,
Control infantile convulsion, expectorant fan, sore throat, swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in,
Parasite killing, hemorrhoid, expediting the emergence of, property is walked and is not kept, also can granulation promoting pain relieving.So dissipate and easily exhaust, be after all cloudy
Tremble with fear also ".Borneolum Syntheticum compatibility Cortex Phellodendri: Borneolum Syntheticum toil is cool in nature, is longer than logical all keys, dissipates stagnated fire, removing nebula improving eyesight,
External energy clearing heat for detumescence, antipruritic pain relieving;Cortex Phellodendri bitter cold, merit arrogates to oneself heat clearing and damp drying, eliminating fire and detoxication, external
Can eliminating dampness and astringing sores.The two phase 5 external only has clearing away heat-fire, removing toxic substances and promoting subsidence of swelling, eliminating dampness and astringing sores, pain relieving
The effect itched, for ministerial drug.
Galla Chinensis, sour in the mouth, puckery, cold in nature, there is pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis,
The merit of removing dampness sore, for chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst,
Have blood in stool hemorrhoidal bleeding, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.Compendium of Material Medica: " control the open sore part not receive:
Galla Chinensis, roasting, grind into powder, adjust with cured vinegar foot and be coated with all around "." Bencao Jingshu ": " ... hold back routed skin ulcer,
Incised wound ... ".Modern pharmacological research has good astriction and antibacterial action, for ministerial drug.
Fructus Cnidii, pungent, bitter, temperature, there is killing parasites for relieving itching, the effect of warming the kidney to invigorate YANG. " book on Chinese herbal medicine justice ":
" " herbal classic " is though claiming its toil for Fructus Cnidii, the product that temperature is the most fiery and forthright.So cure mainly in married woman's the moon swollen
Bitterly ..., " herbal classic " the most main malignant boil, then the medicine of external treatment is also.The damp and hot sufferings of outer infections, all skin ulcers of contaminating,
Can wash as soup, can be that end is applied, produce effects very prompt, be not able to low-priced product and neglect it ", it is clinically used for treating skin
Skin eczema and pruritus.Fructus Cnidii and Radix Sophorae Flavescentis share and are no matter cold-damp and pruritus due to damp pathogen that pyretic toxicity causes has one
It is set for using.The bitter cold toxicity making Radix Sophorae Flavescentis reduces.Share with Rhizoma Coptidis, Radix Sophorae Flavescentis etc., strengthen dampness removing to stop itchin it
Effect, therefore be ministerial drug.
The Fructus Kochiae, acrid in the mouth, hardship, cold in nature." not Lu ": " remove steam in skin, make people moisten, dissipate
Malignant boil hernia abdominal mass, reinforcing YIN-essence ".Function clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, for difficulty and pain in micturition, pudendal pruritus leukorrhagia,
Rubella, eczema, skin pruritus.For adjuvant drug.
Cortex Dictamni, bitter salty, cold.Function parasite killing, antipruritic, dampness, heat clearing away, removing toxic substances.Control pityriasis rosea
Poison, scabies, itchy skin eruption etc., " property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies
Red rotten, eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold;Principal solution heat Huang, wine Huang, acute jaundice, paddy Huang, labor
Yellow etc. "." book on Chinese herbal medicine is original ": " controlling all mange, aversion to wind, scabies, Fructus Myricae rubrae, all skin ulcer pyretic toxicity ".For
Adjuvant drug.
Radix Sophorae Flavescentis, bitter in the mouth, cold in nature.Function heat clearing and damp drying, parasite killing, diuresis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cool
Blood, relieving heat toxin, mange, impetigo poison.Treat skin pruritus, blood tinea corporis skin ulcer, naughty white scales, hemorrhoidal hamorrhage
Hematochezia, has blood in stool.Pathogenic wind expelling, detumescence poison, expectorant poison ".For hematodiarrhoea, have blood in stool, jaundice urine retention, red in vain
Leukorrhagia, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis
Deng.Eczema, skin pruritus, scabies, eczema scrotum etc. had good therapeutic effect.Its main component is bitter
The compositions such as ginseng alkali, sophoridine, supanine, Radix Sophorae Flavescentis alcohol, isokurarinone, kurarinone have antibacterial
Antiinflammatory, diuresis antiallergic etc. act on.For adjuvant drug.
Radix Sanguisorbae, cold in nature, bitter in the mouth acid, there are the effects such as cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore." this
Grass justice ": " Radix Sanguisorbae bitter cold, for the special agent of removing heat from blood.Married woman's mastalgia leukorrhagia, due to Liver Channel stagnated fire the most not
Dredging, bitter cold is to let out clearly it, then irritability is dredged and reached, and this pain can then carry and can stop;The mastalgia that so stagnation of QI expectorant is solidifying,
And the leukorrhagia of deficient QI failing to control, Fei Qizhi is also.Pain relieving is except disliking meat, and infections says it all in addition, and heat in blood fire is contained,
Then bitterly dislike meat more, Radix Sanguisorbae clearing away heat and cooling blood, therefore only infections trouble is had a pain, and can be except disliking meat." herbal classic " again
Treat incised wound, " not record " meaning only pus and blood, malignant boil herpes simplex, incised wound cream can be made, be all this relieve inflammation or internal heat removing heat from blood it
Function.And so-called main seven kinds of impairments, mend wound absolutely, the most all refer to that outer infections says it, non-meaning Radix Sanguisorbae bitter cold, void can be controlled
The impairment caused by overstrain of damage is also ".Modern medicine study proves: Radix Sanguisorbae has hemostasis removing heat from blood, heat-clearing and toxic substances removing, convergence
Antidiarrheal and suppress the effect of multiple pathogenic microorganism and tumor, can treat haematemesis, dysentery, burn wound,
Eczema, upper gastrointestinal hemorrhage, Peptic Ulcers massive hemorrhage, have blood in stool, metrorrhagia, Tuberculous pus infections and chronic bone
The diseases such as marrow is scorching.For adjuvant drug.
Flos Sophorae, bitter in the mouth, cold nature, there is cooling blood for hemostasis, effect of purging liver-fire;Cure mainly hemorrhoidal hamorrhage just
Blood, hemorrhoidal bleeding, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-fire headache, conjunctival congestion and swelling pain,
Sore throat, aphonia, ulcer sores.And from the point of view of doctor trained in Western medicine, Flos Sophorae containing rutin (i.e. rutin, Rytub),
The materials such as Quercetin (Quercetin), tannin, sophoradiol (sophoradiol), vitamin A
(specifically can be found in following containing scale).Rutin can improve the function of blood capillary, keeps blood capillary
Manage normal resistance, prevent because capillary fragility is excessive, permeability is too high cause hemorrhage, high
Blood pressure, diabetes, can preventing of clothes is hemorrhage.For adjuvant drug.
Folium Artemisiae Argyi, pungent, bitter, temperature.Warming the meridian for stopping bleeding, dispersing cold for relieving pain;External removing dampness to relieve itching.External treatment skin
Pruritus, 5 among the cold and cool medicine of group, makes all cold medicines cold and does not just hinder, is allowed to play and preferably controls
Therapeutic effect, plays the effect of " using corrigent ", therefore is adjuvant.
Herba Menthae, it is pungent cool property sweating antipyretic medicine, external can training the mind dysmenorrhoea, skin pruritus, erythra and
Eczema etc..Main component volatile oil, Herba Menthae contains menthol, have antisepsis and sterilization, antiinflammatory, pain relieving,
The effect such as antipruritic.For making medicine.
Pericarpium Granati, sour in the mouth, puckery, warm in nature.Having expelling pus and promoting granulation, hemostasis, the merit of anthelmintic, " book on Chinese herbal medicine converges
Speech ": " treating chilblain is the most rotten does not heals: Pericarpium Granati, Exocarpium Benincasae, Cortex Sacchari sinensis three taste, ashing sustainability, grinds into powder
Apply ".Modern study confirms that various bacteria and fungus are had inhibitory action.For making medicine.
In sum, above all medicines share, and become heat clearing and damp drying altogether, detoxifying and relieving itching, the agent of expelling pus and promoting granulation,
Its mechanism of action is mainly with antiinflammatory, pain relieving, convergence, anticorrosion, granulation promoting, heat-clearing and toxic substances removing, antibacterial, only
Blood, timid rotten evacuation of pus etc., instead of tradition Western medicine--the local treatment of antibiotic, it is therefore prevented that antibiotic exists
The abuse of local.It is applicable to decubital ulcer, diabetic foot and eczema.
Detailed description of the invention
With specific embodiment, the invention will be further described below, but the invention is not limited in these
Embodiment.
Embodiment 1
Rhizoma Coptidis 140g, Radix Scutellariae 160g, Cortex Phellodendri 140g, Borneolum Syntheticum 130g, Galla Chinensis 140g, Fructus Cnidii
130g, Fructus Kochiae 110g, Cortex Dictamni 200g, Radix Sophorae Flavescentis 140g, Radix Sanguisorbae 130g, Flos Sophorae 110g,
Folium Artemisiae Argyi 130g, Herba Menthae 110g, Pericarpium Granati 160g.
Fructus Cnidii, Herba Menthae, Folium Artemisiae Argyi chopping, extract volatile oil with vapor distillation method, and the another device of volatile oil is close
Envelope cold preservation, medicinal residues are standby;Deicing off-chip ten tastes such as medicinal residues and remaining Rhizoma Coptidis add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filtered, dense to about 1000ml, lets cool to the closeest
Between degree 1.03-1.10, add Borneolum Syntheticum and the volatile oil of extraction, 5% ethyl hydroxybenzoate 5-10ml, stirring
Filter after staticly settling 72 hours, filtrate subpackage, pack, check, i.e. obtain lotion.
Embodiment 2
Rhizoma Coptidis 160g, Radix Scutellariae 140g, Cortex Phellodendri 160g, Borneolum Syntheticum 110g, Galla Chinensis 160g, Fructus Cnidii
110g, Fructus Kochiae 130g, Cortex Dictamni 160g, Radix Sophorae Flavescentis 160g, Radix Sanguisorbae 110g, Flos Sophorae 130g,
Folium Artemisiae Argyi 110g, Herba Menthae 130g, Pericarpium Granati 140g.
Fructus Cnidii, Herba Menthae, Folium Artemisiae Argyi chopping, extract volatile oil with vapor distillation method, and the another device of volatile oil is close
Envelope cold preservation, medicinal residues are standby;Deicing off-chip ten tastes such as medicinal residues and remaining Rhizoma Coptidis add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filtered, dense to about 1000ml, lets cool to the closeest
Between degree 1.03-1.10, add Borneolum Syntheticum and the volatile oil of extraction, 5% ethyl hydroxybenzoate 5-10ml, stirring
Filter after staticly settling 72 hours, filtrate subpackage, pack, check, i.e. obtain lotion.
Embodiment 3
Rhizoma Coptidis 150g, Radix Scutellariae 150g, Cortex Phellodendri 150g, Borneolum Syntheticum 120g, Galla Chinensis 150g, Fructus Cnidii
120g, Fructus Kochiae 120g, Cortex Dictamni 180g, Radix Sophorae Flavescentis 150g, Radix Sanguisorbae 120g, Flos Sophorae 120g,
Folium Artemisiae Argyi 120g, Herba Menthae 120g, Pericarpium Granati 150g.
Fructus Cnidii, Herba Menthae, Folium Artemisiae Argyi chopping, extract volatile oil with vapor distillation method, and the another device of volatile oil is close
Envelope cold preservation, medicinal residues are standby;Deicing off-chip ten tastes such as medicinal residues and remaining Rhizoma Coptidis add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filtered, dense to about 1000ml, lets cool to the closeest
Between degree 1.03-1.10, add Borneolum Syntheticum and the volatile oil of extraction, 5% ethyl hydroxybenzoate 5-10ml, stirring
Filter after staticly settling 72 hours, filtrate subpackage, pack, check, i.e. obtain lotion.
Experimental example 4: the embodiment of the present invention 3 treats decubital ulcer, diabetic foot and eczema clinical observation on the therapeutic effect:
Clinical data: observe patient 156 example, decubital ulcer 42 example, diabetic foot 38 example, eczema 76 altogether
Example.
Observational technique
With this preparation clean and smear affected part, usage and dosage: take lotion 100ml add water 500ml dilution
Rear cleaning affected part, clean every time after with undiluted lotion smear affected part (or lotion to soak aseptic dry yarn wet
Apply), every day 2 times (the most each 1 time), within 10 days, it is a course for the treatment of, treats 2 courses for the treatment of.
Result
(1), efficacy assessment standard: judge therapeutic effect according to symptom and sign
1, decubital ulcer:
Recovery from illness: heal completely through treatment wound surface.
Effective: after treatment, wound surface reduces substantially, has more granulation to grow.
Take a turn for the better: removing through the treatment wound surface tissue that rots, secretions reduces.
Invalid: before and after treatment, wound surface is unchanged.
2, diabetic foot:
Cure: patients feet's ulcer surface heals completely, and clinical symptoms disappears substantially.
Effective: patients feet's ulcer surface secretions significantly reduces, and slough comes off, and newly granulates and covers
Lid wound surface, clinical symptoms takes a turn for the better;
Taking a turn for the better: patients feet's ulcer surface secretions reduces, clinical symptoms takes a turn for the better.
Invalid: patients feet infects, gangrene, ulcer without improving, clinical symptoms and sign without progressive or
There is the trend of deterioration.
3, eczema:
Recovery from illness: skin lesion recovers normal, does not itches, or has slight gargalesthesia.
Effective: 70% skin lesion recovers normal, remaining skin lesion gradually takes a turn for the better, with slight pruritus.
Taking a turn for the better: 30% skin lesion recovers normal, remaining skin lesion has plumpness or few liquid to ooze out, with pruritus
Sense, but still can stand.
Invalid: locally skin lesion is less than improvement standard, or without improving, even deteriorate, symptom is without substantially becoming
Change.
(2), therapeutic effect:
1, decubital ulcer: treat decubital ulcer 42 example altogether according to above standard, cures 15 examples, cure rate 35.7%;
Effective 12 examples, obvious effective rate 28.6%;Take a turn for the better 12 examples, improvement rate 28.6%;Invalid 3 examples are invalid
Rate 7.1%;Total effective rate 92.8%.
2, diabetic foot: treat diabetic foot 38 example altogether according to above standard, cures 7 examples, cures
Rate 18.4%;Effective 16 examples, obvious effective rate 42.1%;Take a turn for the better 13 examples, improvement rate 34.2%;Invalid 2
Example, inefficiency 5.3%;Total effective rate 94.7%.
3, eczema: treat eczema 76 example altogether according to above standard, cures 36 examples, cure rate 47.3%;
Effective 21 examples, obvious effective rate 27.6%;Take a turn for the better 17 examples, improvement rate 22.4%;Invalid 2 examples are invalid
Rate 2.6%;Total effective rate 97.4%.
Toxic and side effects
The lotion that embodiment 3 obtains during treating patient without significant discomfort.
Conclusion
By the observation of 156 example patients is treated, prompting: according to above data and clinical observation, this
The lotion of invention has notable therapeutic effect to decubital ulcer, diabetic foot and eczema, has in clinical practice
There are the advantages such as easy to use, cheap, toxic and side effects is little, applied widely, by clinical favorable comment.
Claims (3)
1. the pharmaceutical composition treating decubital ulcer, diabetic foot and eczema, it is characterised in that: should
Pharmaceutical composition is made up of the crude drug of following weight parts:
Rhizoma Coptidis 14-16 part, Radix Scutellariae 14-16 part, Cortex Phellodendri 14-16 part, Borneolum Syntheticum 11-13 part, five times
Sub-14-16 part, Fructus Cnidii 11-13 part, Fructus Kochiae 11-13 part, Cortex Dictamni 16-20 part, Radix Sophorae Flavescentis
14-16 part, Radix Sanguisorbae 11-13 part, Flos Sophorae 11-13 part, Folium Artemisiae Argyi 11-13 part, Herba Menthae 11-13 part,
Pericarpium Granati 14-16 part.
Treatment decubital ulcer the most according to claim 1, diabetic foot and the pharmaceutical composition of eczema,
It is characterized in that: this pharmaceutical composition is made up of the crude drug of following weight parts:
Rhizoma Coptidis 15 parts, Radix Scutellariae 15 parts, Cortex Phellodendri 15 parts, Borneolum Syntheticum 12 parts, Galla Chinensis 15 parts, Serpentis
Machine tool 12 parts, the Fructus Kochiae 12 parts, Cortex Dictamni 18 parts, Radix Sophorae Flavescentis 15 parts, Radix Sanguisorbae 12 parts, Flos Sophorae
12 parts, Folium Artemisiae Argyi 12 parts, Herba Menthae 12 parts, Pericarpium Granati 15 parts.
3. the pharmaceutical composition according to any one of claim 1-2 is at preparation treatment decubital ulcer, glycosuria
Application in the medicine of foot disease and eczema.
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CN116036205A (en) * | 2023-01-03 | 2023-05-02 | 麦莩医疗器械(武汉)有限公司 | Diabetic foot lotion and preparation method thereof |
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