CN105878666A - Six-medicine rice wine and preparation process thereof - Google Patents
Six-medicine rice wine and preparation process thereof Download PDFInfo
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- CN105878666A CN105878666A CN201610360756.6A CN201610360756A CN105878666A CN 105878666 A CN105878666 A CN 105878666A CN 201610360756 A CN201610360756 A CN 201610360756A CN 105878666 A CN105878666 A CN 105878666A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a six-medicine rice wine, which is mainly prepared from the following six medicines by weight: 100g of prepared rehmannia roots, 100g of -prepared fructus corni, 120g of Chinese yam, 25g of moutan bark, 50g of poria cocos and 50g of rhizoma alismatis. The rice wine prepared by the technology has the effects of reinforcing qi, nourishing blood, strengthening the spleen and stomach, tranquilizing the mind by nourishing the heart, enriching yin, nourishing the kidneys and the like, is low in price and simple and convenient to prepare, and has a wide application prospect.
Description
Technical field
The present invention relates to a kind of health promoting wine, particularly relate to a kind of Six-element good fortune wine and preparation technology thereof.
Background technology
Wine, have the title of " length of hundred medicines ", and the taste of Chinese medicine is the most pained tasty, and decocts loaded down with trivial details, but wine then taste is pure and sweet, and end opening makes us aftertaste, is got up with Chinese Medicine and Clavicular by wine, solves these problems, defines new product, be i.e. medicated wine.By the Chinese medicine of building body and wine " molten " in the medicated wine of one, not only prepare conveniently, the property of medicine stable, safe and effective, and because ethanol is a kind of good semi-polarity organic solvent, major part water-soluble substances and water can not dissolve.The Multiple components of Chinese medicine such as alkaloid, salt, tannin, volatile oil, organic acid, resin, saccharide and partial pigment (such as chlorophyll, phylloxanthin) etc. are the most relatively easily soluble in ethanol.Ethanol does not only have good penetrance, it is easy to enters in medical material histiocyte, plays dissolution, promotes displacement, diffusion, is conducive to improving leaching velocity and leaching effect；Also have antisepsis, the hydrolysis of many medicines can be delayed, strengthen the stability of medicament.Alcoholic strength temperature, acrid in the mouth and bitter sweet, have warm promoting blood circulation, a surname to dissipate the efficacy of a drug, warm the intestines and stomach, dispersing wind and cold of dispelling, rouse oneself yang-energy, allaying tiredness etc. acts on.Responsible drinking, can add to the fun with happy feelings, but crosses and drink then unrest, and vigour is then consumed in excessive drinking, even loses one's life.Why doctor likes with wine, is to take its benefaction medicine gesture and reach in internal organs, the property of extremity bones of the body collectively, therefore has the saying of " length that wine is hundred medicines ".In fact, wine is a kind of best solvent, many medicines being difficult to by other processing methods separate out its effective ingredient, mostly can extract by means of this characteristic of wine, and its disease preventing and treating can be given full play to, the drug effect of life lengthening, here it is medicated wine is gone through many decades and is not subtracted the cause place of its glamour.The medicated wine being integrated with the medicine " molten " promoted health and cured diseases by wine, not only has preparation, takes simplicity, and the property of medicine is stable, safely and effectively advantage, more because wine assisting drug, wine help medicine gesture to give full play to effect, improves curative effect.
China has long medicated wine to brewage history, " the Plain Questions nutritious beverage,thick liquor and sweet liquor opinion " in China's medical book Huangdi's Internal Classics the earliest specially piece was once pointed out: " from ancient times sage make the nutritious beverage,thick liquor and sweet liquor; think standby ear ", wine with dregs sweet wine, it it is exactly the drinks made with grain rice, soak with Chinese liquor, yellow wine and rice wine or decoct and there is treatment and the various Chinese medicines of nourishing character or food, remove the oral wine of medicinal residues gained, be medicated wine；In Yin business period, except " wine ", outside " sweet wine ", also having " Yichang ", Yichang is with Egyptain millet as liquor-making raw material, adds what Radix Curcumae Rhizoma et radix valerianae was led to, and this is the medicated wine the earliest having literature record；Ming Dynasty's Li Shizhen (1518-1593 A.D.) has recorded more than 200 kind tonic wine prescriptions in Compendium of Material Medica, also has other famous expert's masterpiece a lot of, and the medicated wine of record is many.
Along with the enhancing of health of people consciousness, medicated wine market expands rapidly, sets up having in China's Chinese medicine and modern healthy theoretical basis and keeps fit and the medicated wine product of health care is especially by the welcome on market, and its prospect is become better and better.These medicated wine have catered to the consumption demand that people's health care consciousness is the strongest, are had deep love for by modern.
Summary of the invention
It is an object of the invention to the deficiency overcoming prior art to exist, Six-element medicated wine and preparation technology thereof that a kind of Nutrition and health-care effect have both are provided, present inventor combines secret prescription handed down in the family from generation to generation according to forefathers' experience, by the research to Chinese medicine, and combine dialectical demonstration, in many ways collect the length of many families, seek best of breed scheme
Suffer from a deficiency of the kidney and refer to that renal function weakens, need according to different symptom medical treatments.The deficiency in both YIN and YANG of kidney, kidney qi metaplasia is not enough, and disease sees spermatorrhea, premature ejaculation, and after urine, the sound of rain pattering is not to the utmost, and total urination time is many and clear soreness of the waist and knees, auditory dysesthesia, breathes hard, and extremity are the warmest, thready and weak pulse etc..Causing the reason suffered from a deficiency of the kidney to have a lot, congenital heredity factor, pressure are excessive, overworked, the sick kidney that also can destroy human body such as respiratory tract infection, urinary system infection, nephritis, renal calculus.
The traditional Chinese medical science is thought, kidney has the functions such as store essential substances, main growth, growth, reproduction, main water liquid metabolism, is referred to as " the congenital foundation ".It is to cause visceral dysfunction that deficiency of the kidney essence is damaged, and produces one of key factor of disease.Therefore many people using foster kidney as the important measures of anti-aging.Medicine for the kidney invigorating has much currently on the market, but generally has that price is higher, the unconspicuous defect of health-care effect and a problem.The healthy medicated wine of the present invention, formula is simple, curative effect is obvious, has the function of enriching yin and nourishing kidney, and its manufacture is simple and convenient, and kidney tonifying functions is notable, has no side effect.
For achieving the above object, the present invention provides a kind of Six-element good fortune wine, and it includes following weight raw material:
Radix Rehmanniae Preparata 100g, wine Fructus Corni 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g,
Its preparation method is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10%(w/w) sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) take Rhizoma Dioscoreae, Poria and Rhizoma Alismatis and put into container, add the distilled water of 3 times amount, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times amount distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times amount distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata, wine Fructus Corni add in Chinese liquor 10kg and get final product.
Preferably, good fortune wine of the present invention is with Radix Rehmanniae Preparata, wine Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Poria, Rhizoma Alismatis six medicaments as main component, and it includes the raw material of following weight:
Radix Rehmanniae Preparata 100g, wine Fructus Corni 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g,
Rhizoma Chuanxiong 30g, Herba Scutellariae Barbatae 30g, Herba Epimedii 30g, Cortex Eucommiae 30g, Radix Salviae Miltiorrhizae 25g, Fructus Ligustri Lucidi 25g,
Radix Polygoni Multiflori 20g, Rhizoma Atractylodis Macrocephalae 20g, Cortex Cinnamomi 20g, Semen Ziziphi Spinosae 20g, Radix Curcumae 15g, Fructus Lycii 15g.
Its preparation method is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10% sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate is added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) take Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Fructus Lycii put into container, add the distilled water of 3 times amount, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times amount distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times amount distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata, wine Fructus Corni, Herba Scutellariae Barbatae, Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Cortex Cinnamomi, Radix Curcumae are added in Chinese liquor 10kg and get final product.
The addition of sodium chloride in the present invention, substantially increases the extraction ratio of paeonol.There is certain dissolubility due to paeonol in the hot water, in extracting solution, add certain density salt reduce its dissolubility in water, accelerate its dissolution, thus shorten extraction time；Medicated wine of the present invention has an effect such as benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach, tranquilizing by nourishing the heart, enriching yin and nourishing kidney, the insomnia and dreamful sleep that the heart, spleen, stomach, deficiency of the kidney yin are caused, indolent and listless vexed, dyspepsia unable, uncomfortable in chest, have a dizzy spell, the symptom such as waist soreness improves highly significant.The soreness of the waist and knees that causes therefrom particular for male, insomnia and dreamful sleep, night sweat, frequent micturition, sexual disorder, immunity degradation, hypomnesis have significant curative effect；In addition to effect of crude drug, ethanol also can promote drug effect, helps digest, promotes appetite, blood circulation promoting, warming up is healthy and strong, and helps for sleep, eliminates stress, and patient can drink this medicated wine the most in daily life, ill controls, and anosis prevents.
Detailed description of the invention
Embodiment 1
A kind of Six-element good fortune wine, it includes following weight raw material:
Radix Rehmanniae Preparata 100g, wine Fructus Corni (having another name called Fructus Corni) 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g,
Its preparation method is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10% sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate is added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) take Rhizoma Dioscoreae, Poria and Rhizoma Alismatis and put into container, add the distilled water of 3 times amount, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times amount distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times amount distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata, wine Fructus Corni add in Chinese liquor 10kg and get final product.
Embodiment 2
A kind of Six-element good fortune wine with Radix Rehmanniae Preparata, wine Fructus Corni, Rhizoma Dioscoreae, Cortex Moutan, Poria, Rhizoma Alismatis six medicaments as main component, it includes the raw material of following weight:
Radix Rehmanniae Preparata 100g, wine Fructus Corni (having another name called Fructus Corni) 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g,
Rhizoma Chuanxiong 30g, Herba Scutellariae Barbatae 30g, Herba Epimedii 30g, Cortex Eucommiae 30g, Radix Salviae Miltiorrhizae 25g, Fructus Ligustri Lucidi 25g,
Radix Polygoni Multiflori 20g, Rhizoma Atractylodis Macrocephalae 20g, Cortex Cinnamomi 20g, Semen Ziziphi Spinosae 20g, Radix Curcumae 15g, Fructus Lycii 15g.
Its preparation method is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10% sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate is added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) take Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Fructus Lycii put into container, add the distilled water of 3 times amount, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times amount distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times amount distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata, wine Fructus Corni, Herba Scutellariae Barbatae, Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Cortex Cinnamomi, Radix Curcumae are added in Chinese liquor 10kg and get final product.
Embodiment 3
Safety testing
Laboratory animal and environment: cleaning grade SD rat, Kunming mouse.Experimental situation temperature 21 DEG C-25 DEG C, humidity 40%-58% during experiment.
Acute toxicity test in mice: the healthy Kunming mouse 20 selecting body weight to be 18g-22g, male and female half and half.The medicated wine gavage of Example 1,2 preparation respectively, each gavage volume is 0.2ml/10g bw.Continuous Observation two weeks after gavage, record poisoning manifestations and death condition.
30 days feeding trials: select the SD rat of just ablactation to be randomly divided into three groups, i.e. matched group and embodiment 1,2 tested groups, often group 20, male and female half and half.Matched group gives isopyknic distilled water.Give animal subject gavage respectively, every day gavage once, gavage volume is 2ml/100g.bw, continuous 30 days.Each treated animal all feeds to feed in normal diet, cage, free diet, drinking-water.
Assay:
1. acute oral LD50 result: the acute oral LD50 to mice female, male, belongs to non-poisonous material.
2.30 days feeding trial results: experimental group per os gavage 30 days, during test, animal growth is good, and each dosage group body weight, weightening finish, food utilization, routine blood indexes, blood biochemistry index, organ coefficient compare with matched group, there was no significant difference (P ＞ 0.05).Gross anatomy has no the abnormal change relevant with sample with tissue pathology checking.Prompting submitted sample is fed observation index every to rat for 30 days and is not produced obvious toxic-side effects.
Embodiment 4
Clinical data
Randomly choose clinic case Patients with Kidney Deficiency Type 80 example, be randomly divided into two groups, often organize 40 people, two groups at aspects such as age, the course of disease, the state of an illness through statistical procedures, there was no significant difference (P ＞ 0.05), there is comparability.
Diagnostic criteria: whole nation combination of Chinese and Western medicine deficiency syndrome and senile disease research Professional Committee are to nephrasthenia syndrome diagnosis, it is desirable to possess with purgation three: ache of the spinal column (except traumatic)；Soreness of waist and knee or talalgia；Tinnitus or deafness；Loss of hairs or luxated tooth；The heeltap or incontinence is had after urine；Sexual hypofunction, infertile, sterile.
Therapeutic Method:
Matched group takes the medicated wine of embodiment 1 preparation, drinks 10-30 milliliter every time, drinks 1-2 time every day.It within 1 month, it is 1 course for the treatment of；
Treatment group takes the medicated wine of embodiment 2 preparation, drinks 10-30 milliliter every time, drinks 1-2 time every day.It within 1 month, it is 1 course for the treatment of；
Through treatment, Patients with Kidney Deficiency Type transference cure 1 year not recidivist is recovery from illness；The person of having clear improvement is for taking a turn for the better.The symptom person of being not improved is invalid.
Result of study is shown in Table 1:
Table 1
| Number | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 40 | 25 | 12 | 3 | 92.5% |
| Matched group | 40 | 19 | 9 | 12 | 70% |
Embodiment 5
Model case
Mr. Gao, 47 years old, soreness of the waist and knees, nocturia was frequent; dribbling urination, and the cold fear of body is cold, inappetence; lethargy, takes medicated wine of the present invention half a year continuously, adheres to drink 30mL during supper; above-mentioned symptom takes a turn for the better, and no longer gets up in the night to urinate, and urine is smooth and easy; waist and leg ache sense disappears, and extremity are warm effectively, can go to work in the fields the most dizzy; spiritedness, maintain the most always, have no that disease recurs.
Above-mentioned each Chinese medicine interaction compatibility that the present invention uses, can play its synergism, has drug effect and be interweaved and mutually promote and coordinate usefulness between each composition of raw material of Chinese medicine used, and the medicated wine of the application is with low cost, and effect is notable, has broad application prospects.
Claims (5)
1. a Six-element good fortune wine, it includes the raw material of following weight:
Radix Rehmanniae Preparata 100g, wine Fructus Corni 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g.
Wine the most according to claim 1, it is characterised in that the preparation method of described wine is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10% sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate is added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) take Rhizoma Dioscoreae, Poria and Rhizoma Alismatis and put into container, add the distilled water of 3 times of weight, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times of weight distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times of weight distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata and wine Fructus Corni to add to successively in Chinese liquor 10kg, to obtain final product.
Wine the most according to claim 1, it is characterised in that include the raw material of following weight:
Radix Rehmanniae Preparata 100g, wine Fructus Corni 100g, Rhizoma Dioscoreae 120g, Cortex Moutan 25g, Poria 50g, Rhizoma Alismatis 50g,
Rhizoma Chuanxiong 30g, Herba Scutellariae Barbatae 30g, Herba Epimedii 30g, Cortex Eucommiae 30g, Radix Salviae Miltiorrhizae 25g, Fructus Ligustri Lucidi 25g,
Radix Polygoni Multiflori 20g, Rhizoma Atractylodis Macrocephalae 20g, Cortex Cinnamomi 20g, Semen Ziziphi Spinosae 20g, Radix Curcumae 15g, Fructus Lycii 15g.
Wine the most according to claim 3, its preparation method is as follows:
(1) use steam distillation, take Cortex Moutan 25g, add 10% sodium chloride solution 250mL as Extraction solvent, prepare distillate, distillate is added 1mol/L hydrochloric acid solution and makes crystallization, prepared composition A；
(2) Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Fructus Lycii are taken, mixing, put into container, add the distilled water of 3 times of weight, after soaking 1 hour, boil 2 hours, extract decoction liquor；Again add 3 times of weight distilled water, boil 1 hour, extract decoction liquor；Finally, add 3 times of weight distilled water, heated and boiled 1 hour, extract decoction liquor；Merging three decoction liquor, be condensed into the extractum that density is 1.2g/ml, 60 DEG C dried, pulverizes prepared composition B；
(3) take composition A, composition B, Radix Rehmanniae Preparata, wine Fructus Corni, Herba Scutellariae Barbatae, Herba Epimedii, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Cortex Cinnamomi, Radix Curcumae are added in Chinese liquor 10kg and get final product.
5. the purposes of medicated wine described in claim 1-4.
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