CN105878218A - Preparation method of intelligent children's fever cooling patch - Google Patents
Preparation method of intelligent children's fever cooling patch Download PDFInfo
- Publication number
- CN105878218A CN105878218A CN201610250084.3A CN201610250084A CN105878218A CN 105878218 A CN105878218 A CN 105878218A CN 201610250084 A CN201610250084 A CN 201610250084A CN 105878218 A CN105878218 A CN 105878218A
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- mass ratio
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- defervescence plaster
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/0241—Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a preparation method of an intelligent children's fever cooling patch. The fever cooling patch is composed of a backing layer, a gel layer and a net diaphragm, the net diaphragm and the backing layer are positioned on an upper layer and a lower layer of the gel layer respectively, the backing layer is nonwoven cloth, the net diaphragm is a PET film, a PC rubber sheet or a PC film, and the gel layer is formed by mixing distilled water, high molecular substance, a humectant, a natural cooling agent and a heat absorbing agent according to a certain proportion. The humectant, the natural cooling agent and heat absorbing agent are loaded in high molecular gel to realize effects of lowering temperature and bringing down a fever. The intelligent children's fever cooling patch is free of toxic and side effect and has obvious physical cooling and fever abating effect.
Description
Technical field
The present invention relates to the preparation method that a kind of intelligence child is defervescence plaster used.
Background technology
Product of bringing down a fever in the market is mainly febrifuge and defervescence plaster used, and febrifuge divides for oral administration and external two kinds, for
Infant should avoid taking of medicine as far as possible, and external febrifuge effect is not it is obvious that the current defervescence plaster used market mainstream is
Defervescence plaster used, defervescence plaster used main based on hydrogel, some employing hydrogels add auxiliary material, and auxiliary material is freshener, Chinese medicine
And wetting agent, walk heat by substantial amounts of moisture evaporator strip contained in hydrogel, auxiliary material delays the evaporation of moisture, during increase
Effect property, reaches the purpose persistently brought down a fever.
When defect is to have a fever according to human body, the change of temperature carries out the regulation of temperature at any time, ageing the most also
Short, not up to satisfactory results.
Summary of the invention
The technical problem to be solved is to provide the preparation method that a kind of intelligence child is defervescence plaster used.Prepared
Defervescence plaster used can according to human body fever degree be automatically adjusted temperature, reach certain intellectuality.
In order to solve above-mentioned technical problem, the present invention by the following technical solutions: a kind of intelligence defervescence plaster used preparation of child
Method, it is characterised in that follow the steps below:
1), joining in stirred tank by polymer substance and distilled water according to certain mass ratio, be heated to 60～98 DEG C, stirring is extremely
Being completely dissolved, product is referred to as product A；
2), by product A being cooled to 35～50 DEG C, add the wetting agent of certain mass ratio, natural freshener and heat absorbent, stirring is all
Even；
3), it is cooled to room temperature, is allowed to quickly become gel state, obtains hydrogel；
4), being coated with on backing layer with hydrogel, coating layer thickness is 0.25mm～1mm, shears to obtain defervescence plaster used semi-finished product；
5), on defervescence plaster used, press net barrier film, be packaged to be defervescence plaster used finished product；
Described polymer substance be polyacrylamide, sodium polyacrylate, sodium alginate, guar gum, sodium carboxymethyl cellulose and
A kind of or arbitrary proportion in polyvinyl alcohol two or more；Described wetting agent is in glycerol, propylene glycol and sorbitol
Kind or arbitrary proportion two or more；Described natural freshener is two of a kind of or arbitrary proportion in Oleum menthae and menthol
Kind；Described heat absorbent is the two or more of a kind of or arbitrary proportion in ammonium nitrate, ammonium chloride, potassium nitrate and carbamide；
The mass ratio of described polymer substance and distilled water is 3～15:85～97；Product A, wetting agent, natural freshener and suction
The mass ratio of thermit powder is 10～80:0.1～5:0.1～5:10～90.
Described backing layer is non-woven fabrics.
Described net barrier film is PET film, PC film or PC film.
In step 1), polymer substance and distilled water are according to mass ratio 8:92, and polymer substance is polyvinyl alcohol and carboxylic first
Base sodium cellulosate compounds according to mass ratio 5:3, is heated to 85 DEG C；
Step 2) in, it being cooled to 32 DEG C, the mass ratio of product A, wetting agent, natural freshener and heat absorbent is 53:1.5:1.5:
44, wherein wetting agent is that glycerol and propylene glycol compound according to mass ratio 1:0.5, natural freshener be Oleum menthae and menthol by
Compounding according to mass ratio 1:0.5, heat absorbent is that carbamide and potassium nitrate compound according to mass ratio 17:27；
In step 4), coating layer thickness is 0.5mm.
The present invention has a following Advantageous Effects:
1, heat absorbent is that a kind of being dissolved in the water absorbs the material of heat, the change of the solubility with temperature of heat absorbent and change,
Temperature more high-dissolvability is the biggest, absorbs heat the most, and the low then dissolubility of temperature is little, absorbs heat also few, defervescence plaster used in use,
Touch human body, utilize the temperature of human body to make defervescence plaster used middle hydrogel temperature raise, thus increase heat absorbent in hydrogel
Dissolubility, promote the dissolving of heat absorbent, heat absorbent absorbs heat in course of dissolution thus reduces defervescence plaster used temperature
Degree, further slows down the volatilization of moisture, improves defervescence plaster used ageing.
2, absorbing heat how much with temperature is relevant due to heat absorbent, when using product of the present invention, human body fever temperature is sent out
Changing, influences whether defervescence plaster used temperature, thus has influence on heat absorbent dissolubility in hydrogel, and therefore heat absorbent absorbs
Heat also in change, defervescence plaster used thus certain intellectuality will be reached according to body temperature change regulation own temperature.
Detailed description of the invention
The present invention is further illustrated below in conjunction with instantiation.
Embodiment 1
Polyvinyl alcohol and distilled water are added in stirred tank according to mass ratio 7:93, is heated to 97 DEG C, stir to being completely dissolved, for
Product A, be cooled to 45 DEG C for semigel state, add glycerol, Oleum menthae and carbamide, stir, product A, glycerol, thin
The mass ratio of lotus oil and carbamide is 40:0.5:0.5:59, is rapidly cooled to room temperature, is allowed to quickly become gel state, uses water-setting
Glue is coated with on non-woven fabrics, and coating layer thickness is 0.3mm, shears to obtain defervescence plaster used semi-finished product, presses PET film on defervescence plaster used, packaging
Obtain defervescence plaster used finished product.
Embodiment 2
Polyvinyl alcohol, sodium carboxymethyl cellulose and distilled water are added in stirred tank according to mass ratio 5:3:92, are heated to 97 DEG C,
Stirring is to being completely dissolved, and for product A, being cooled to 35 DEG C is semigel state, adds glycerol, propylene glycol, Oleum menthae, Herba Menthae
Alcohol, carbamide and potassium nitrate, stir, the quality of product A, glycerol, propylene glycol, Oleum menthae, menthol, carbamide and potassium nitrate
Ratio is 53:1:0.5:1:0.5:17:27, is rapidly cooled to room temperature, is allowed to quickly become gel state, with hydrogel at non-woven fabrics
Upper coating, coating layer thickness is 0.5mm, shears to obtain defervescence plaster used semi-finished product, presses PC film on defervescence plaster used, is packaged to be defervescence plaster used one-tenth
Product.
Embodiment 3
Sodium polyacrylate, polyacrylamide, sodium alginate and distilled water are added in stirred tank according to mass ratio 5:1:4:90, adds
Heat is to 85 DEG C, and stirring is to being completely dissolved, and for product A, being cooled to 45 DEG C is semigel state, adds glycerol, menthol and urine
Element, stirs, and the mass ratio of product A, glycerol, menthol and carbamide is 50:1:3:46, is rapidly cooled to room temperature, is allowed to
Quickly becoming gel state, be coated with hydrogel on non-woven fabrics, coating layer thickness is 0.6mm, shears to obtain defervescence plaster used semi-finished product,
Press PC film on defervescence plaster used, be packaged to be defervescence plaster used finished product.
Embodiment 4
Sodium polyacrylate, sodium alginate, sodium carboxymethyl cellulose and distilled water are added stirred tank according to mass ratio 5:2:4:89
In, it being heated to 82 DEG C, stirring is to being completely dissolved, and for product A, being cooled to 40 DEG C is semigel state, adds glycerol, Oleum menthae
And ammonium chloride, stirring, the mass ratio of product A, glycerol, Oleum menthae and ammonium chloride is 41:4:5:50, is rapidly cooled to room
Temperature, is allowed to quickly become gel state, is coated with on non-woven fabrics with hydrogel, and coating layer thickness is 0.8mm, shear defervescence plaster used half
Finished product, presses PC film on defervescence plaster used, is packaged to be defervescence plaster used finished product.
Further illustrate below in conjunction with experimental data and the method have the benefit that
1 physical data
Inventor collects 420 example children fevers between in June, 2014 in January, 2016 altogether, the age just birth to 6 one full year of life it
Between, for the most defervescence plaster used (except not adding heat absorbent, other manufacture method is same as in Example 2), embodiment 1, embodiment 2, reality
Execute example 3, embodiment 4 does effectiveness comparison.
1.2 experimental technique
Laboratory sample is affixed on forehead.
1.3 experimental design
420 examples are carried out respectively 5 kinds of defervescence plaster used experiments, has often organized 84 people.
2 experimental results
The most defervescence plaster used (except not adding heat absorbent, other manufacture method is same as in Example 2) investigation satisfaction is 68.1%；Implement
It is 77.2% that example 1 investigates satisfaction；It is 83.2% that embodiment 2 investigates satisfaction；It is 81.9% that embodiment 3 investigates satisfaction；Embodiment
4 investigation satisfactions are 79.7%.
3 are satisfied with standard
Sticking rear child not cry and scream, the persistent period is long, and effect of bringing down a fever is obvious.
4 discuss
Fever may be caused by many reasons, and the fever that common cold is caused by the present invention has obvious effect, it is proposed that Bao Bao
In the case of fever is less than 38.5, use Physical temperature-lowering, it is to avoid the medicine injury to baby, if prolonged hay fever suggestion is gone as far as possible
Local hospital is gone to a doctor, in order to avoid delaying treatment；The present invention is to temperature sense sensitive, in order to reach optimum efficiency, should be saved in
At Yin Liang, it is to avoid sunlight irradiates.
Claims (4)
1. the preparation method that an intelligent child is defervescence plaster used, it is characterised in that follow the steps below:
1), joining in stirred tank by polymer substance and distilled water according to certain mass ratio, be heated to 60～98 DEG C, stirring is extremely
Being completely dissolved, product is referred to as product A；
2), by product A being cooled to 35～50 DEG C, add the wetting agent of certain mass ratio, natural freshener and heat absorbent, stirring is all
Even；
3), it is cooled to room temperature, is allowed to quickly become gel state, obtains hydrogel；
4), being coated with on backing layer with hydrogel, coating layer thickness is 0.25mm～1mm, shears to obtain defervescence plaster used semi-finished product；
5), on defervescence plaster used, press net barrier film, be packaged to be defervescence plaster used finished product；
Described polymer substance be polyacrylamide, sodium polyacrylate, sodium alginate, guar gum, sodium carboxymethyl cellulose and
A kind of or arbitrary proportion in polyvinyl alcohol two or more；Described wetting agent is in glycerol, propylene glycol and sorbitol
Kind or arbitrary proportion two or more；Described natural freshener is two of a kind of or arbitrary proportion in Oleum menthae and menthol
Kind；Described heat absorbent is the two or more of a kind of or arbitrary proportion in ammonium nitrate, ammonium chloride, potassium nitrate and carbamide；
The mass ratio of described polymer substance and distilled water is 3～15:85～97；Product A, wetting agent, natural freshener and suction
The mass ratio of thermit powder is 10～80:0.1～5:0.1～5:10～90.
2. the preparation method that intelligence child as claimed in claim 1 is defervescence plaster used, it is characterised in that: described backing layer is nonwoven
Cloth.
3. the preparation method that intelligence child as claimed in claim 1 is defervescence plaster used, it is characterised in that: described net barrier film be PET film,
PC film or PC film.
4. the preparation method that intelligence child as claimed in claim 1 is defervescence plaster used, it is characterised in that:
In step 1), polymer substance and distilled water are according to mass ratio 8:92, and polymer substance is polyvinyl alcohol and carboxymethyl fibre
Dimension element sodium compounds according to mass ratio 5:3, is heated to 85 DEG C；
Step 2) in, it being cooled to 32 DEG C, the mass ratio of product A, wetting agent, natural freshener and heat absorbent is 53:1.5:1.5:
44, wherein wetting agent is that glycerol and propylene glycol compound according to mass ratio 1:0.5, natural freshener be Oleum menthae and menthol by
Compounding according to mass ratio 1:0.5, heat absorbent is that carbamide and potassium nitrate compound according to mass ratio 17:27；
In step 4), coating layer thickness is 0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610250084.3A CN105878218A (en) | 2016-04-21 | 2016-04-21 | Preparation method of intelligent children's fever cooling patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610250084.3A CN105878218A (en) | 2016-04-21 | 2016-04-21 | Preparation method of intelligent children's fever cooling patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105878218A true CN105878218A (en) | 2016-08-24 |
Family
ID=56704197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610250084.3A Pending CN105878218A (en) | 2016-04-21 | 2016-04-21 | Preparation method of intelligent children's fever cooling patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105878218A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186615A (en) * | 2018-03-23 | 2018-06-22 | 青岛海洋生物医药研究院 | It is a kind of degradable defervescence plaster used and preparation method thereof |
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
| CN115105462A (en) * | 2022-07-22 | 2022-09-27 | 绍兴百立盛新材料科技有限公司 | Preparation method of antipyretic gel |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186615A (en) * | 2018-03-23 | 2018-06-22 | 青岛海洋生物医药研究院 | It is a kind of degradable defervescence plaster used and preparation method thereof |
| CN108186615B (en) * | 2018-03-23 | 2021-02-02 | 青岛海洋生物医药研究院 | Degradable fever cooling patch and preparation method thereof |
| CN111297834A (en) * | 2020-04-19 | 2020-06-19 | 田文超 | Cooling paste |
| CN111450048A (en) * | 2020-04-19 | 2020-07-28 | 田文超 | Gel for antipyretic patch and preparation method thereof |
| CN111297834B (en) * | 2020-04-19 | 2023-05-26 | 田文超 | Defervescing plaster |
| CN111450048B (en) * | 2020-04-19 | 2023-12-22 | 广州市雨纯生物科技有限公司 | Gel for antipyretic patch and preparation method thereof |
| CN115105462A (en) * | 2022-07-22 | 2022-09-27 | 绍兴百立盛新材料科技有限公司 | Preparation method of antipyretic gel |
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Application publication date: 20160824 |
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