CN105833220A - Traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors - Google Patents

Traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors Download PDF

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CN105833220A
CN105833220A CN201610255114.XA CN201610255114A CN105833220A CN 105833220 A CN105833220 A CN 105833220A CN 201610255114 A CN201610255114 A CN 201610255114A CN 105833220 A CN105833220 A CN 105833220A
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radix
chinese medicine
medicine composition
malignant tumor
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CN105833220B (en
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俞超芹
王汝倩
翟东霞
张丹英
俞瑾
程雯
姚瑞嫔
白玲玲
武梅
韩萍
单婧
周玲
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Second Military Medical University SMMU
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Abstract

The invention discloses a traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-45 parts of codonopsis pilosula, 15-45 parts of milkvetch root, 9-30 parts of snakegourd root, 9-30 parts of largehead atractylodes rhizome, 9-15 parts of tuckahoe, 15-45 parts of danshen root, 9-15 parts of tangerine peel, 9-15 parts of bitter orange, 15-30 parts of ark shell, 3-15 parts of dried toad skin, 3-12 parts of dried ginger, 15-45 parts of barbed skullcap herb, 15-45 parts of root of valvate actinidia, 15-45 parts of coix seed, 15-45 parts of lucid ganoderma, and 15-45 parts of spreading hedyotis herb. The invention also discloses an application of the traditional Chinese medicine composition for assistant treatment of gynecologic malignant tumors. The traditional Chinese medicine composition disclosed by the invention has the advantages of being definite in curative effect, small in toxic or side effect, low in cost, and convenient for popularization and application.

Description

A kind of Chinese medicine composition assisting treatment gynecologic malignant tumor and purposes
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition assisting treatment gynecologic malignant tumor.
Background technology
Common in gynecologic malignant tumor have cervical cancer, ovarian cancer, carcinoma of endometrium.
Cervical cancer (cervical cancer) is modal gynecologic malignant tumor, and the age occurred frequently is 50～55 years old.Major histological Type is scale cancer, accounts for cervical cancer 75%-80%, and adenocarcinoma is taken second place, and accounts for 20%-25%.Direct extension and lymphatic metastasis are cervical cancers Main route of metastasis.
The clinical manifestation of cervical cancer predominantly vaginal contact is bled, neoplasm etc..
1, colporrhagia: often show as colporrhagia after contact bleeding, i.e. sexual life or gynecologial examination.Can also appear as vagina Irregularly bleed, or menostaxis, menorrhagia.Gerontal patient is often the irregular colporrhagia of post menopausal.General exogenic cancer Hemorrhage relatively morning, amount is many；Interior raw type cancer is hemorrhage later.
2, neoplasm: most of patients has white or courage and uprightness, thin such as water sample or water from washing rice shape, the neoplasm having bad smell.Evening Phase patient infects because of cancerous tissue necrosis companion, can have a large amount of water from washing rice sample or purulence fetor ex vagina.
3, symptom in late period: involve scope according to focus late period and different Secondary Symptoms occurs.As frequent micturition, urgent micturition, constipation, under Limb swells and ache；When cancerous protuberance is oppressed or involves ureter, ureteral obstruction, hydronephrosis and uremia can be caused；Can have late period anemia, The cachexia symptoms such as cachexia.
The treatment of cervical cancer at present includes operation, radiotherapy, chemotherapy and Comprehensive Treatment.Early cervical carcinoma patient (I-IIA1) may select Simple radical surgery and simple radical radiation therapy, both therapeutic effect are suitable, and within 5 years, survival rate, mortality rate, complication occur Rate is similar.Each phase cervical cancer all may select radiotherapy.For more than IIB stage middle-advanced cervical carcinoma and Locally advanced cervical carcinoma (IB2 and The IIA2 phase) use the Synchronous chemoradiotherapy based on cisplatin.The selection of therapeutic modality should according to patient age, histological type, point Phases etc. consider.But the prognosis of cervical cancer is relevant with clinical stages, histological type, lymphatic metastasis, Therapeutic Method etc., There is lymph metastasis person's poor prognosis.
Malignant tumor of ovary (ovarian cancer) is one of common three big malignant tumor of female sex organs.Owing to ovarian cancer is sent out Sick concealment and lack perfect method of early diagnosis, for late period (FIGO by stages, III phase and IV phase) when about 70% patient makes a definite diagnosis, And relapse rate about 70% after standard care, its mortality rate occupies the first place of gynecologic malignant tumor.Malignant ovarian tumor type is numerous Many, different types of tumor has different biological behaviours.Direct extension, peritoneal seeding, lymph metastasis are malignants tumor of ovary Main route of metastasis, hematogenous metastasis is less, can be transferred to lung, pleura and liver late period.
Malignant tumor of ovary is the most asymptomatic, therefore is not easy to be found, and late period, cardinal symptom was abdominal distention, abdominal mass, abdominal cavity Hydrops and other symptoms of digestive tract；The cachexia performances such as some patients can be become thin, anemia.
Malignant tumor of ovary one is it has been observed that should row ocal resection treat, and carries out pathological, clarifies a diagnosis.Postoperative Decide whether to accept auxiliary therapy according to its histological type, cell differentiation, value of surgical-pathological staging and remaining stove size, change Treatment is the most clinical main auxiliary treatment means, and advanced ovarian carcinoma relapse rate is high, and prognosis is poor.
Carcinoma of endometrium (endometrial carcinoma) is the one group of epithelial malignancy betiding endometrium, to derive from The adenocarcinoma of endometrial gland is most common.For one of big malignant tumor of female genital tract three, average age of onset is 60 years old, wherein 75% betides more than 50 years old women.In recent years sickness rate is the most in rising trend.Route of metastasis be mainly direct extension, Lymph metastasis, has hematogenous metastasis late period.
There is colporrhagia or neoplasm, little asymptomatic person in the patient of its clinical manifestation about 90%.
1, colporrhagia: mainly show as post menopausal colporrhagia, measures the most few, and the person of bleeding profusely is rare, or persistence Or intermittence bleeds；Not yet menopause person can behave as menstruation increase, menostaxis or intermenstrual bleeding.
2, neoplasm: mostly being serosity or serosity courage and uprightness discharge opeing in early days, late period, concurrent infection then had septic discharge opeing, stench.
3, there is inferior belly gas pain and spasm sample pain in hypogastralgia: if cancerous protuberance involves cervix uteri internal orifice, can cause pyometra.Evening Phase wellability surrounding tissue or pressuring nerve can cause lower abdomen and waist and sacrum pain.
4, General Symptoms: may occur in which anemia late period, become thin, generate heat and the symptom such as cachexia.
Carcinoma of endometrium primary treatments is treated for operation, radiotherapy and medicine (chemicals and hormone).Early stage patient is with hands Art treatment is main, postoperative according to high risk factor selection auxiliary treatment.The high risk factor affecting carcinoma of endometrium prognosis has: non-uterus Inner membrance sample cancer or poorly differentiated adenocarcinoma, deep Myometrial involvement, vascular space is invaded, gross tumor volume is big, cervix uteri transfer, lymph are carried down Move and transfer outside uterus etc..
Suffering from the surgical patient of gynecologic malignant tumor, often because of preoperative or postoperative lose blood, carcinous consumption, the factor such as stress causes Occur having a delicate constitution, weak, infantile anorexia, the symptom such as insomnia.During adjuvant chemotherapy or the patient of palliative chemotherapy, chemotherapy There will be nausea and vomiting, loss of appetite, constipation or the untoward reaction such as diarrhoea, general malaise；Patients after Chemotherapy there will be bone marrow and presses down System, hypoimmunity, pale complexion, limbs fatigue, even some patients can not complete auxiliary because of serious bone marrow depression Treat the course for the treatment of.Radiocurable patient can produce the side effect such as radiation enteritis, radiocystitis and pelvic adhesion, the most easily Bone marrow depression, hypoimmunity occur.Gynecologic malignant tumor relapse rate is higher, and the relapse rate after treatment of human cervical cancer was in 1 year 50%, it was 75%～80% in 2 years.In carcinoma of endometrium 75%～95% is recurred 2～3 years after surgery, and ovarian cancer standard After treatment, relapse rate is up to 55%～75%.Therefore, how to improve that gynecologic malignant tumor patient is postoperative, chemotherapy and the life of radiotherapy Quality, improves immunity, reduces the toxicity of chemicotherapy, the suppression growth of tumor, prevention of recurrence and extend the survival of patients phase It it is the great research topic of current Gynecology.
Summary of the invention
It is an object of the invention to provide the Chinese drug-treated group that a kind of side effect is little, can treat gynecologic malignant tumor with the auxiliary of long-term taking Compound.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of Chinese medicine composition, is made up of the component of following weight portion: Radix Codonopsis 15-45 part, Radix Astragali 15-45 part, Radix Trichosanthis 9-30 Part, Rhizoma Atractylodis Macrocephalae 9-30 part, Poria 9-15 part, Radix Salviae Miltiorrhizae 15-45 part, Pericarpium Citri Reticulatae 9-15 part, Fructus Aurantii 9-15 part, Concha Arcae 15-30 part, dry Cutis Bufonis 3-15 part, Rhizoma Zingiberis 3-12 part, Herba Scutellariae Barbatae 15-45 part, Radix actinidiae valvatae's 15-45 part, Semen Coicis 15-45 part, Ganoderma 15-45 part, Herba Hedyotidis Diffusae 15-45 part.
Described Chinese medicine composition is made up of the component of following weight portion: Radix Codonopsis 15 parts, the Radix Astragali 30 parts, Radix Trichosanthis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 Part, 12 parts of Poria, Radix Salviae Miltiorrhizae 30 parts, Pericarpium Citri Reticulatae 9 parts, Fructus Aurantii 12 parts, Concha Arcae 15 parts, dry maxima skin 9 parts, Rhizoma Zingiberis 6 parts, Herba Scutellariae Barbatae 30 parts, Herba Hedyotidis Diffusae 30 parts, Radix actinidiae valvatae 30 parts, Semen Coicis 30 parts, Ganoderma 30 parts.
In above-mentioned composition, dry maxima skin is monarch drug, and Radix Codonopsis, the Radix Astragali, Radix Trichosanthis are ministerial drug, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Aurantii, Radix Salviae Miltiorrhizae, Concha Arcae, Rhizoma Zingiberis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Radix actinidiae valvatae, Semen Coicis, Ganoderma are combined into adjuvant drug.
The application in preparation auxiliary treatment gynecologic malignant tumor medicine of a kind of described Chinese medicine composition.
Described gynecologic malignant tumor, such as cervical cancer, ovarian cancer, carcinoma of endometrium etc..
Described auxiliary treatment, refers to improve that gynecologic malignant tumor patient is postoperative, chemotherapy and the quality of life of radiotherapy, improves immunity Power, the toxicity of minimizing chemicotherapy, the suppression growth of tumor, prevention of recurrence and prolongation survival of patients phase etc..
Described auxiliary treatment, refers to coordinate conventional chemotherapy or radiotherapy；
It is following that gynecologic malignant tumor uses routine of western medicine chemotherapy regimen to include at present: paclitaxel+platinum class, gemcitabine+platinum class, torr Pool, for health+platinum class, etoposide+platinum class etc., coordinates the Chinese medicine composition of the present invention on the basis of routine of western medicine chemotherapy regimen, Also referred to as drug combination or the combination of Chinese and Western medicine.
A kind of pharmaceutical preparation assisting treatment gynecologic malignant tumor, and medically may be used as active ingredient containing described Chinese medicine composition The carrier accepted.
Described pharmaceutical preparation is granule, tablet, electuary, powder, capsule, oral liquid or drop pill.
The present invention is directed to gynecologic malignant tumor pathogenesis, use supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, the Therapeutic Principle of right supporting anticancer, Chinese medicine Pharmaceutical composition is raw materials used inexpensive, and side effect is little, can long-term taking.Through clinical application for many years and observation analysis, this Chinese drug-treated group Compound, to auxiliary treatment gynecologic malignant tumor, improves patients ' life quality, delays recurrence and survival of patients phase to have preferable clinic Curative effect.In view of gynecologic malignant tumor morbidity crowd's quantity is big, and patient's poor life quality after operation, chemicotherapy, the state of an illness easily recurs, Therefore the Chinese medicine composition that the present invention provides has a good application prospect.
Gynecologic malignant tumor of the present invention includes cervical cancer, ovarian cancer, carcinoma of endometrium Deng Shu motherland's medical science " abdominal mass ", " stone Abdominal mass ", " intestinal gill fungus ", the category such as " stomachache ".Ancient medicine understanding substantially diseases caused by exogenous pathogenic factor six climate exopathogens, internal injury to gynecological tumor etiology and pathogenesis Diet, seven emotions are got along well, and nurse accidentally, and deficiency of vital QI causes qi depression to blood stasis, expectorant to tie wet stopping, and the expectorant stasis of blood is fought and tied in punching times uterus Become.As "Nei Jing" opinion " mass in the abdomen " " cold visitor, in parenteral, fights with defending gas phase, and gas must not be flourish, has direct bearing, addiction all through the ages because being And interior work, bad odor has been, polyp is raw." Jing-Yue Complete Works think " blood stasis is detained work, the card that only married woman has ... or long-pending Labor is amassed weak, and gas is weak and not all right, and when always being moved by blood, remaining blood is not clean, and one is the most inverse, then study in Japan long-pending, and gradually becomes disease." " woman People's complete works good recipe " once pointed out: " if taking advantage of exopathogen and closing negative and positive, then lower abdomen breast the side of body back coupling and pain, menses is uncomfortable, swelling in the moon, Dribbling urination, yellow complexion is black, then give birth to tumor." " all source of disease marquis opinion " also speech: " if menses do not close negative and positive to the greatest extent, even married woman's blood Arteries and veins contraction is anxious ... because of raw accumulation, such as pregnant shape." etc..Chinese medicine the pathogenesis of tumor is mainly summarised as " poison, the stasis of blood, expectorant, Empty " four aspects, its Therapeutic Principle one is righting (improve overall health of patients, improve immunity etc.), and two be eliminating evil (to suppress tumor Cell grows).Carcinoma consumption hinders energy and blood of human body body fluid, gynecologic malignant tumor especially advanced malignant tumor patient, and cancer poison pents up, Deficiency of YIN leading to consumption of QI, evil more Sheng and the most empty, therefore primary disease simulataneous insufficiency and excessive, deficiency in origin and excess in superficiality, and show as main with the moon wound, deficiency of vital energy pathogenesis. Therefore, while radiation and chemotherapy and after end of chemotherapy, answer supplementing QI and nourishing YIN, detoxicating and fighting cancer, be aided with blood stasis-eliminating and stagnation-dissipating, regulate the flow of vital energy it Product.
In the Chinese medicine composition of the present invention, dry maxima skin is the dry skin of Bufonidae animal Bufo siccus or black surround Bufo siccus.It is pungent cool, Slightly poisonous, there is the function such as heat-clearing and toxic substances removing, diuretic relieving distension, be recorded in the earliest " herbal classic is met former ", be after Bufo siccus removes Venenum Bufonis, internal organs The thing dried, classical prescription is used as medicine, and purpose mostly is treating the poisonous disease with poisonous drugs, in recent years for kinds cancer or combined with chemotherapy, radiotherapy, can not only Improve curative effect, moreover it is possible to alleviate Radiotherapy chemotherapy side effect, the principal agent combined for this.Radix Codonopsis is sweet flat, invigorating the spleen and replenishing QI, promotes the production of body fluid and nourishes blood； Radix Astragali tonifying Qi and lifting yang, benefit defends consolidating superficial resistance；Radix Trichosanthis, clearing away heat-fire, spermatogenesis quenches the thirst, detumescence and apocenosis, and this three tastes medicine is played QI invigorating altogether and supported The moon, promoting the production of body fluid to quench thirst, the effect of right supporting anticancer.Poria eliminating dampness by diuresis spleen invigorating mind calming；Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm；Rhizoma Atractylodis Macrocephalae QI invigorating is good for Spleen, dampness diuretic.Spleen is " the foundation of acquired constitution, source of generating QI and blood ", these three medicine regulating qi-flowing for strengthening spleen, strengthens the effect of QI invigorating righting. Breast, alleviating distention in middle-JIAO de-swelling are opened in Fructus Aurantii circulation of qi promoting.Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing.Compendium of Material Medica calls it " can break stagnated blood, mend fresh blood ", " the sensible opinion of gynecological " has saying of " Radix Salviae Miltiorrhizae dissipating simply, the same SIWU TANG of merit ", the kind blood vessels that can pass through of this product, stasis-dispelling and pain-killing.Concha Arcae Son, relieving gastric hyperacidity to alleviate stomachache, Rhizoma Zingiberis warming stomach for dispelling cold preventing or arresting vomiting, dry maxima skin is joined Concha Arcae, Rhizoma Zingiberis, is had the effect solving cancer poison and do not injure one's stomach.Cat Radix Ginseng, heat-clearing and toxic substances removing, anticancer；Herba Scutellariae Barbatae, heat-clearing and toxic substances removing, anticancer；Herba Hedyotidis Diffusae, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, anti- Cancer；Semen Coicis, invigorating spleen for diuresis detumescence, clearing away heat and discharging pus, anticancer.Above four is plant anticarcinogen, the anticancer effect of modern study The best.Ganoderma, qi-restoratives is calmed the nerves, and strengthens the effect of right supporting anticancer.In a word, above all medicine the monarch and his subjects are clearly demarcated, assistant makes to work as, and play clear altogether Thermal detoxification, supplementing QI and nourishing YIN, effect of right supporting anticancer.
Owing to using technique scheme, the present invention has the following advantages and beneficial effect:
The Chinese medicine composition of the present invention has determined curative effect, and toxic and side effects is little, with low cost, it is simple to the advantage of popularization and application.
Detailed description of the invention
In conjunction with embodiment, the present invention is described in detail, but embodiments of the invention are not only limited to this.
The experimental technique of unreceipted actual conditions in the following example, generally according to normal condition, or according to proposed by manufacturer Condition.Medical material used by the embodiment of the present invention, except as otherwise indicating, all can obtain from Chinese crude drug sales company.The medical material obtained Except as otherwise indicating, it is tcm and herbal slice.Decoction pieces both can obtain from sales company, it is also possible to be obtain after through processing.
Embodiment 1
Prepared by the decoction of the present invention
Weigh Radix Codonopsis 15g, Radix Astragali 30g, Radix Trichosanthis 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Concha Arcae 15g, dry maxima skin 9g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 30g, Herba Hedyotidis Diffusae 30g, Radix actinidiae valvatae 30g, Semen Coicis 30g, Ganoderma 30g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese drug-treated group of the present invention The water decoction of compound.
Embodiment 2
Prepared by the granule of the present invention
Weigh Radix Codonopsis 15g, Radix Astragali 30g, Radix Trichosanthis 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Concha Arcae 15g, dry maxima skin 9g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 30g, Herba Hedyotidis Diffusae 30g, Radix actinidiae valvatae 30g, Semen Coicis 30g, Ganoderma 30g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese drug-treated group of the present invention The water extract of compound, adds dextrin and Icing Sugar mixing after concentration, with appropriate 70% ethanol soft material, cross No. 1 sieve series grain, do for 50 DEG C Dry 2 hours, dry granule crossed 12～14 mesh sieve granulate, subpackage, obtains the granule of the Chinese medicine composition of the present invention.
Embodiment 3
Prepared by the tablet of the present invention
Weigh Radix Codonopsis 15g, Radix Astragali 30g, Radix Trichosanthis 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Concha Arcae 15g, dry maxima skin 9g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 30g, Herba Hedyotidis Diffusae 30g, Radix actinidiae valvatae 30g, Semen Coicis 30g, Ganoderma 30g。
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese medicine of the present invention The water extract of compositions, adds microcrystalline Cellulose and starch mixing, adds appropriate 70% ethanol soft material, cross No. 1 sieve series grain, 50 DEG C are dried 2 hours, and dry granule crosses 12～14 mesh sieve granulate, add magnesium stearate, mixing, tabletting, obtain the present invention's The tablet of Chinese medicine composition.
Embodiment 4
The classical case of the present invention
Side certain, female, in April, 1976 be born, people from Yangzhou, Jiangsu.Patient in 2013-9-16 day because of " squamous carcinoma of the cervix postoperative February Remaining " medical.In local hospital row cervical biopsy, pathology returned and showed: mucosa because of vaginal hemorrhage after having sexual intercourse patient's 2013-6-10 day Tissue chronic inflammatory disease companion's high-level tumor of epithelium becomes, CINIII level gland involvement, focal zone cancer in situ, 2013-6-24 day row LEEP Cutter is treated, and pathology shows: (cervix uteri central authorities) squamous cell carcinoma, middle differentiation, intramural invasion 0.5cm, suspicious vascular cancer embolus.Then in Popularity uterus+bilateral salpingo+lymph node resection+bilateral ovaries suspension under 2013-7-14 day row general anesthesia, post operative diagnosis is " palace The carcinoma of neck Ib phase ".The treatment such as non-row radiotherapy chemotherapy after operation in patients.2013-9-14 day outer court checks B ultrasonic prompting Right Lower Abdomen capsule group Block (6.3*3.8cm).2013-9-16 day, my section was medical, gave pelvic cavity CT examination, and prompting recurrence companion's psoas major, right ovary turn Moving, right side external iliac vein is invaded.Then take in institute, in my section's row docetaxel+cisplatin systemic chemotherapy 1 time, 2013-10-5 day because of Occurring IV degree bone marrow depression after chemotherapy, after giving the treatments such as platelet transfusion, three is slight rising.2013-10-16 day row bone marrow aspiration Result is pointed out: the active proliferation of grain system, and red system substantially active companion three is morbid state myelogram.Because patient three is low, not followed by continuing Chemotherapy, the cancer that disappeared flat intravenous drip Traditional Chinese Medicine Anti oncotherapy.Patient mental's state is poor, and performance status is poor, appetite appetite Typically, sleep quality still can, defecation is without exception, xerostomia, and the dark red tongue of tongue is few, thready and rapid pulse.Give supplementing QI and nourishing YIN, heat clearing away solution Poison, right supporting anticancer is treated.Side with Radix Codonopsis 30g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 12g, Radix Trichosanthis 15g, Poria 12g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Concha Arcae 15g, dry maxima skin 9g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 30g, Radix actinidiae valvatae 30g, Semen Coicis 30g, Ganoderma 30g, Herba Hedyotidis Diffusae 30g.Further consultation after 2 weeks, patient is weak the most slightly better.Former side changes Radix Astragali 30g, strengthens righting QI invigorating.Further consultation after 2 weeks, weak improvement, sleep can, xerostomia take a turn for the better, give Chinese medicine Radix Codonopsis 15g, Radix Astragali 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Trichosanthis 15g, Poria 15g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Concha Arcae 15g, dry maxima skin 12g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 30g, Herba Hedyotidis Diffusae 30g, Radix actinidiae valvatae 45g, Semen Coicis 30g, Ganoderma 30g.This side rear takes medicine more than 2 years always, Slightly adding and subtracting with simultaneous phenomenon, the period check indices prompting state of an illness that has regular physical checkups is controlled, and has no progress.In the recent period in 2015 Further consultation on August 16, inspection SCC 0.8 μ g/L, CA125 4.8U/ml, TCT (-), pelvic MRI: after operation for cervical carcinoma, Lesser tubercle the most similar (diameter about 0.7cm) in the pelvic cavity of right side, the multiple small lymph node of bilateral inguinal.Anter is similar therewith, carries Show stable disease, patient's private prosecution since postoperative recurrence, because of can not chemotherapy, adhere to pure treatment by Chinese herbs always, Morbidity control is more flat Surely, muscle power situation is clearly better earlier above, and sleep is obviously improved, without significant discomfort.
Embodiment 5
Grandson, female, in February, 1958 is born, married, Zhejiang Hangzhou people.Patient in 2014-9-9 because of " ovarian cancer IIIc phase art Latter more than 23 months, CA125 raised August " in outpatient clinic.Patient subtracts in 2012-10-15 day local hospital row oophoroma tumor Going out art, clinical diagnosis is the ovary low differentiation serous papillary adenocarcinoma IIIc phase, and suffered from postoperative row chemotherapy 8 times, concrete medication is not quite clear. The 2014-1 month gives chemotherapy new with U.S. 4 times because CA125 raises outer court, drops not yet, existing CA125 > 1000U/ml, pelvic cavity CT: The multiple lymph node of mesentery, a small amount of hydrops of pelvic cavity.Consider her ovaries's cancer low differentiation cystadenocarcinoma IIIc phase postoperative recurrence.Patient is certainly Feeling weak, spirit is not good enough, and constipation with dry stool is difficult to resolve, poor appetite, enters abdominal distention after meal, xerostomia, purplish tongue thick fur, thready and rolling pulse.Receive Giving Chinese medicine supplementing QI and nourishing YIN during giving docetaxel+carboplatin chemotherapy, chemotherapy after living my section, regulating the flow of QI to ease the stomach, detoxicating and fighting cancer are treated. Side with Radix Codonopsis 15g, Radix Astragali 15g, Poria 9g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii 12g, Radix actinidiae valvatae 30g, Herba Hedyotidis Diffusae 30g, half Lotus 30g, dry maxima skin 9g, Concha Arcae 15g, Rhizoma Zingiberis 6g, Ganoderma 30g, Radix Trichosanthis 15g, Semen Coicis 15g, Radix Salviae Miltiorrhizae 15g, Rhizoma Atractylodis Macrocephalae 15g.(9-16 day) outpatient service further consultation after 1 week, after private prosecution chemotherapy, spirit is poor, and poor appetite is the most weak, xerostomia, tongue Red, greasy fur, thready and rolling pulse.Side with Radix Codonopsis 45g, Radix Astragali 45g, Radix Trichosanthis 30g, Rhizoma Atractylodis Macrocephalae 30g, Poria 15g, Pericarpium Citri Reticulatae 12g, Fructus Aurantii 15g, Radix actinidiae valvatae 30g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, dry maxima skin 9g, Concha Arcae 15g, Rhizoma Zingiberis 6g, spirit Sesame 30g, Radix Salviae Miltiorrhizae 30g, Semen Coicis 45g.Further consultation after 2 weeks, patient's ordinary circumstance takes a turn for the better earlier above, stomach receive can, mouth is not done, tongue Purple, thready and rolling pulse.Side with Radix Codonopsis 30g, Radix Astragali 30g, Poria 12g, Radix Trichosanthis 18g, Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 30g, Fructus Aurantii 15g, Dry maxima skin 12g, Concha Arcae 15g, Rhizoma Zingiberis 3g, Radix actinidiae valvatae 45g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Semen Coicis 30g, Ganoderma 30g, Radix Salviae Miltiorrhizae 30g.Completing chemotherapy after Patients on Recurrence 4 times, CA125 is aided with this during dropping to 25U/ml, chemotherapy Bright Chinese medicine composition, suitably adds and subtracts according to symptom, supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, and right supporting anticancer is treated.After Chemotherapy in Patients terminates Oral etoposide maintaining treatment, is aided with Traditional Chinese Drug Anticancer so far.Since patient's private prosecution recurrence, during chemotherapy and after end of chemotherapy, Adhering to Chinese medicine auxiliary treatment, hence it is evident that feel weak and be clearly better earlier above, muscle power situation takes a turn for the better earlier above, and stomach is received and taken a turn for the better earlier above, the state of an illness Controlled, had abdominal discomfort sense though even, it is considered to for tissue adhesion, but the most substantially alleviated.
Embodiment 6
Ni, female is born in August, 1945, people from Anhui.2012-9-27 day is because " postoperative nearly 4 years of carcinoma of endometrium finds lung Shift 1 day " medical.Patient examined erasion in 2008 because of abnormal vaginal bleeding row, and pathology is carcinoma of endometrium, in 10-21 Full uterus+bilateral adnexectomy+posterior wall colporrhaphy, postoperative pathological: endometrioid adenocarcinoma under day row peritoneoscope.Postoperative Row docetaxel+oxaliplatin systemic chemotherapy 6 times.Within 2010, playing patient and occur that discontinuity is coughed, 2012-09 month breast CT carries Show that right lung cancer is accompanied the possibility of transfer, bronchoscope pathology: adenocarcinoma of lung probability is big in the lung of side.PET-CT points out carcinoma of endometrium Postoperative, two lungs and the transfer of right lung hilar lymph nodes.Patient gives docetaxel+carboplatin systemic chemotherapy in 2012-10-11 after moving in, Patient's discontinuity cough and expectoration, spirit poor, muscle power situation still can, xerostomia, vexed, red tongue greasy fur, thready and rolling pulse, big dry stool Knot.It is aided with Chinese medicine YIN nourishing and the production of body fluid promoting, relieving cough and resolving phlegm, heat-clearing and toxic substances removing, right supporting anticancer.Side Radix Codonopsis 15g, Radix Astragali 15g, the Rhizoma Atractylodis Macrocephalae 18g, Poria 15g, Pericarpium Citri Reticulatae 12g, Radix Trichosanthis 15g, Radix Salviae Miltiorrhizae 30g, dry maxima skin 12g, Concha Arcae 15g, Rhizoma Zingiberis 6g, cat people Ginseng 45g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Semen Coicis 45g, Ganoderma 30g, Fructus Aurantii 15g.After 1 week (10-20 day) Further consultation, patient is the most weak, and cough and expectoration takes a turn for the better earlier above, and mouth is the most dry.Side Radix Codonopsis 30g, Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Pericarpium Citri Reticulatae 9g, Radix Salviae Miltiorrhizae 30g, Radix Trichosanthis 18g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Radix actinidiae valvatae 45g, dry maxima skin 12g, Concha Arcae 15g, Rhizoma Zingiberis 6g, Semen Coicis 45g, Ganoderma 30g, Fructus Aurantii 12g.Be admitted to hospital after 2 weeks preparation row recurrence after second Secondary chemotherapy, patient's muscle power situation still can, mental status is good, dry cough once in a while, and without expectorant, without vexed, red tongue greasy fur, lower limb are sour Swollen improvement, remaining without uncomfortable.Give Radix Codonopsis 18g, Radix Astragali 18g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Pericarpium Citri Reticulatae 9g, Radix Salviae Miltiorrhizae 30g, sky Pollen 30g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Radix actinidiae valvatae 30g, dry maxima skin 12g, Concha Arcae 15g, Rhizoma Zingiberis 6g, Semen Coicis 30g, Ganoderma 30g, Fructus Aurantii 12g.4 end of chemotherapy of patient, take megestrol sheet endocrine therapy and Chinese drug-treated group Conjunction side treats more than 3 years.After patient's private prosecution self-discovery Lung metastases, adhere to taking Chinese medicine auxiliary during chemotherapy and after end of chemotherapy anti- Cancer, the period check indices prompting state of an illness is controlled, and has no that progress, patient's muscle power situation are clearly better, without significant discomfort Main suit.
Embodiment 7
The clinical observation of the present invention
Case is originated: case is collected from January, 2009 between in December, 2014, goes to a doctor in The 2nd Army Medical College attached Changhai doctor III c phase ovarian cancer patients 65 example of institute's TCM Gynecology hospitalization.Wherein 23 example combination of Chinese and Western medicine group (A group) age 41～78 Year, average (57.36 ± 8.77) year.Histological type: serous adenocarcinoma 19 example, endometrioid adenocarcinoma 1 example, other types 3 examples.Histo-differentiation: low differentiation 11 example, middle differentiation 0 example, other 12 examples.History of past illness: hypertension history 8 example.42 examples Doctor trained in Western medicine group (B group) age 39～75 years old, average (53.81 ± 8.72) year.Histological type serous adenocarcinoma 22 example, intrauterine Film sample adenocarcinoma 15 example, other types 15 example.Histo-differentiation: low differentiation 18 example, middle differentiation 6 example, other 18 examples.Previously History: hypertension history 5 example, diabetic history 2 example.
Inclusive criteria: 1. pathology is clarified a diagnosis late period (FIGO by stages, the III c phase) ovarian epithelium of parallel surgical cytoreduction Cancer patient.2. the malignant tumor of ovary relapse criteria formulated according to obstetrics and gynecology branch of Chinese Medical Association gynecological oncology group: tumor Mark raises；Ascites pleural fluid occurs；Physical examination finds lump；Imaging examination finds lump；There is unknown cause intestinal obstruction. The most every simply by the presence of 1, i.e. it is contemplated that tumor recurrence.3. Ka Shi scoring (KPS) marks >=60 points.The most every inspection refers to Indication is treated in reference symbol combination, avoids without chemotherapy.
Exclusion standard: 1. not met inclusive criteria；2. baseline file is deficient；3. patient and family members thereof are unwilling to coordinate return visit.
Observation of curative effect:
Doctor trained in Western medicine group: include III c phase ovarian cancer patients 42 example altogether in, all use routine of western medicine chemotherapy regimen, paclitaxel+platinum class, Ji His shore+platinum class, hycamtin+platinum class, etoposide+platinum classes etc. of west, calculate Chemotherapy in Patients medicine according to patient body surface areas Dosage.Chemotherapy regimen row chemotherapy is more then changed such as disease progression.
Combination of Chinese and Western medicine group: 23 examples, increases traditional Chinese medical herbal treatment on the basis of above-mentioned doctor trained in Western medicine group chemotherapy.During chemotherapy and chemotherapy After daily this Chinese medicine composition side, be decocted in water for oral dose, the most each take the most continuously, add and subtract to the ill according to disease change.
Following up a case by regular visits to content: the patient's regular telephone included in is followed up a case by regular visits to Survival, deadline is in Decembers, 2014 or patient's appearance Termination event (dead).
Observation of curative effect: the median survival time of the above-mentioned two groups of patients included in is compared；With age of patient, histological type, Histo-differentiation, being covariant with or without family tumor history and therapeutic modality, with Overall survival (OS) as dependent variable, row Cox returns Model analysis；The survival rate of 1～5 year of two groups is compared.
The Cox analysis of regression model of OS influence factor is as shown in table 1, and two groups of survival rates of 1～5 year are as shown in table 2.
Table 1
Table 2
Clinical observation on the therapeutic effect shows, combination of Chinese and Western medicine group totally 23 example after Chinese medicine composition of the present invention intervention, wherein 5 example patient Dead；Simple doctor trained in Western medicine group totally 42 example, wherein 19 example death.Combination of Chinese and Western medicine group median survival time 61 months, west Doctor organizes 52 months, two groups of comparing difference not statistically significant (χ2=0.322, P=0.570).The knot of Cox analysis of regression model Fruit display: the HR value of therapeutic modality be 0.213 (95%CI:0.067～0.683, P < 0.05)；Result shows: Chinese and western medicine is tied Closing treatment and the improvement of patient OS is better than simple western medical treatment, but to delete mistake rate higher due to two groups of patients, OS may lack clinic It is worth.(table 1) combination of Chinese and Western medicine group 1 year, 2 years survival rates and doctor trained in Western medicine group comparing difference not statistically significant (P > 0.05)； Combination of Chinese and Western medicine group 3 years, 4 years, 5 years survival rates apparently higher than doctor trained in Western medicine group, difference statistically significant (P < 0.05) (table 2).
These results suggest that, the combined therapy of Chinese and Western medicine plays an important role in the treatment of recurrent ovarian carcinoma.After surgery and Combine Chinese medicine during Radiotherapy chemotherapy and can strengthen patient's body constitution, improve the survival of patients phase.
Embodiment 8
Weigh Radix Codonopsis 45g, Radix Astragali 15g, Radix Trichosanthis 30g, Rhizoma Atractylodis Macrocephalae 30g, Poria 9g, Radix Salviae Miltiorrhizae 15g, Pericarpium Citri Reticulatae 15g, Fructus Aurantii 9g, Concha Arcae 30g, dry maxima skin 3g, Rhizoma Zingiberis 9g, Herba Scutellariae Barbatae 45g, Herba Hedyotidis Diffusae 15g, Radix actinidiae valvatae 45g, Semen Coicis 45g, Ganoderma 45g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese drug-treated group of the present invention The water decoction of compound.
Embodiment 9
Weigh Radix Codonopsis 20g, Radix Astragali 45g, Radix Trichosanthis 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 15g, Radix Salviae Miltiorrhizae 45g, Pericarpium Citri Reticulatae 12g, Fructus Aurantii 15g, Concha Arcae 20g, dry maxima skin 15g, Rhizoma Zingiberis 12g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 45g, Radix actinidiae valvatae 15g, Semen Coicis 15g, Ganoderma 15g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese medicine of the present invention The water decoction of compositions.
Embodiment 10
Weigh Radix Codonopsis 25g, Radix Astragali 25g, Radix Trichosanthis 20g, Rhizoma Atractylodis Macrocephalae 20g, Poria 10g, Radix Salviae Miltiorrhizae 25g, Pericarpium Citri Reticulatae 10g, Fructus Aurantii 10g, Concha Arcae 25g, dry maxima skin 6g, Rhizoma Zingiberis 3g, Herba Scutellariae Barbatae 25g, Herba Hedyotidis Diffusae 25g, Radix actinidiae valvatae 25g, Semen Coicis 25g, Ganoderma 25g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese medicine of the present invention The water decoction of compositions.
Embodiment 11
Weigh Radix Codonopsis 35g, Radix Astragali 35g, Radix Trichosanthis 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria 14g, Radix Salviae Miltiorrhizae 35g, Pericarpium Citri Reticulatae 14g, Fructus Aurantii 14g, Concha Arcae 22g, dry maxima skin 10g, Rhizoma Zingiberis 6g, Herba Scutellariae Barbatae 35g, Herba Hedyotidis Diffusae 35g, Radix actinidiae valvatae 35g, Semen Coicis 35g, Ganoderma 35g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese medicine of the present invention The water decoction of compositions.
Embodiment 12
Weigh Radix Codonopsis 40g, Radix Astragali 40g, Radix Trichosanthis 25g, Rhizoma Atractylodis Macrocephalae 25g, Poria 13g, Radix Salviae Miltiorrhizae 40g, Pericarpium Citri Reticulatae 13g, Fructus Aurantii 13g, Concha Arcae 28g, dry maxima skin 8g, Rhizoma Zingiberis 8g, Herba Scutellariae Barbatae 40g, Herba Hedyotidis Diffusae 40g, Radix actinidiae valvatae 40g, Semen Coicis 40g, Ganoderma 40g.
Soak more than 2 hours in container after rinsing with water, after normal pressure decocts 30 minutes, leach medicinal liquid, obtain Chinese medicine of the present invention The water decoction of compositions.
The ultimate principle of the present invention, principal character and advantages of the present invention have more than been shown and described.The technical staff of the industry should This understanding, the present invention is not restricted to the described embodiments, and the simply explanation present invention's described in above-described embodiment and description is former Reason, the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements are all Fall in scope of the claimed invention.Claimed scope is defined by appending claims and equivalent thereof.

Claims (7)

1. the Chinese medicine composition assisting treatment gynecologic malignant tumor, it is characterised in that: described Chinese medicine composition is by following weight The component of part is made: Radix Codonopsis 15-45 part, Radix Astragali 15-45 part, Radix Trichosanthis 9-30 part, Rhizoma Atractylodis Macrocephalae 9-30 part, Poria 9-15 part, Radix Salviae Miltiorrhizae 15-45 part, Pericarpium Citri Reticulatae 9-15 part, Fructus Aurantii 9-15 part, Concha Arcae 15-30 part, dry maxima skin 3-15 part, Rhizoma Zingiberis 3-12 part, Herba Scutellariae Barbatae 15-45 Part, Radix actinidiae valvatae's 15-45 part, Semen Coicis 15-45 part, Ganoderma 15-45 part, Herba Hedyotidis Diffusae 15-45 part.
Chinese medicine composition the most according to claim 1, it is characterised in that: described Chinese medicine composition is by the group of following weight portion Divide and make: Radix Codonopsis 15 parts, the Radix Astragali 30 parts, Radix Trichosanthis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, 12 parts of Poria, Radix Salviae Miltiorrhizae 30 parts, Pericarpium Citri Reticulatae 9 parts, trifoliate orange 12 parts of shell, Concha Arcae 15 parts, dry maxima skin 9 parts, Rhizoma Zingiberis 6 parts, Herba Scutellariae Barbatae 30 parts, Herba Hedyotidis Diffusae 30 parts, Radix actinidiae valvatae 30 parts, Semen Coicis 30 parts, Ganoderma 30 parts.
3. the application in preparation auxiliary treatment gynecologic malignant tumor medicine of the Chinese medicine composition described in a claim 1 or 2.
Application the most according to claim 3, it is characterised in that described gynecologic malignant tumor be cervical cancer, ovarian cancer or Carcinoma of endometrium.
Application the most according to claim 3, it is characterised in that described auxiliary treatment refers in conventional chemotherapy or radiotherapy On the basis of coordinate the Chinese medicine composition of the present invention.
6. the pharmaceutical preparation assisting treatment gynecologic malignant tumor, it is characterised in that: in as claimed in claim 1 or 2 Drug composition is as active ingredient and medically acceptable carrier.
The pharmaceutical preparation of auxiliary treatment gynecologic malignant tumor the most according to claim 4, it is characterised in that: described medicine system Agent is granule, tablet, electuary, powder, capsule, oral liquid or drop pill.
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CN101502636A (en) * 2009-03-05 2009-08-12 张晋玮 Pure medicinal formulation for treating cancer and preparation method thereof
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