CN105833179A - 治疗非酒精性脂肪性肝炎的中药 - Google Patents
治疗非酒精性脂肪性肝炎的中药 Download PDFInfo
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Abstract
一种治疗非酒精性脂肪性肝炎的中药,各组分的质量份配比为:桑叶15‑25、荷叶蒂15‑25、当归15‑25、桂枝8‑25、薏米10‑25、炒麦芽10‑25、紫苏10‑15、柴胡10‑25、决明子15‑30、海藻12‑25、昆布12‑25、半夏3‑5、首乌15‑25、郁金8‑15、田基黄10‑15、丹参15‑25、绞股蓝18‑25、泽泻10‑15、黄精10‑24,山楂15‑20、枳壳15‑25、女贞子12‑25、枸杞12‑25、银杏叶12‑15。诸药合用对降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度具良好作用疗效,无毒副作用。
Description
技术领域
本发明涉及一种中药组合物,特别是一种治疗非酒精性脂肪性肝炎的中药组合物。
背景技术
临床流行病学研究表明,近年来随着人们生活习惯和饮食结构的改变,以及影像学的进步和广泛应用,脂肪肝的检出率日益增多,发病率不断升高。脂肪肝已成为仅次于病毒性肝炎的第二大肝病,已被公认为肝硬化的常见原因之一,非酒精性脂肪性肝炎起因多为过食肥甘厚味、过度肥胖或情志失调,或久病体虚。其发病机制为肝失疏泄,脾失健运,湿热内结,痰浊郁结,淤血阻滞,而最终形成痰湿淤阻互结,痹阻肝脏脉络而形成脂肪肝,病理基础与痰、瘀、湿、积有关,与肝、脾、肾三脏功能关系密切。目前西医治疗没有效药物,中医药治疗取得了一定的疗效。治以健脾祛湿,化痰消积,活血化瘀为主。
发明内容
本发明的目的在于提供一种治疗非酒精性脂肪性肝炎的中药,解决脂肪肝的治疗问题。
为实现上述目的,本发明采用的技术方案是:一种治疗非酒精性脂肪性肝炎的中药,其特征在于:各组分的质量份配比为:桑叶15-25、荷叶蒂15-25、当归15-25、桂枝8-25、薏米10-25、炒麦芽10-25、紫苏10-15、柴胡10-25、决明子15-30、海藻12-25、昆布12-25、半夏3-5、首乌15-25、郁金8-15、田基黄10-15、丹参15-25、绞股蓝18-25、泽泻10-15、黄精10-24,山楂15-20、枳壳15-25、女贞子12-25、枸杞12-25、银杏叶12-15。
上述的一种治疗非酒精性脂肪性肝炎的中药,其特征在于:各组分的重量份配比为:桑叶25、荷叶蒂25、薏米25、当归25、桂枝15、炒麦芽25、紫苏15、柴胡20、决明子30、海藻25、昆布20、半夏3、首乌25、郁金15、田基黄15、丹参25、绞股蓝25、泽泻15、黄精24、山楂18、枳壳25、女贞子12、枸杞25、银杏叶15。
本发明所述的治疗非酒精性脂肪性肝炎的中药,可制成汤剂,制作方法为:将各原料清洗干净,用冷水下药,浸泡10分钟后上火,武火至沸后用中火煮20分钟,煎煮两遍将汤剂混合,分早晚两次温服。连续服用15-20天,下月开始第二疗程。也可制成膏剂、浓缩片、丸剂,以上各成分也可制成超细状态的药粉状,做成胶囊,连续服用。
本发明的优点在于,方中桑叶、紫苏、柴胡、黄精、女贞子滋补肝肾、疏肝养肝解郁;银杏叶、当归、桂枝、丹参、首乌、郁金行气、活血养血、补益精血;炒麦芽、山楂、枳壳消食化积,理气健脾、化湿和胃;薏米、决明子、海藻、昆布、半夏、泽泻利水消肿,渗湿,泄热,降血脂、改善肝功、改善肝脂肪代谢,有抗脂肪肝作用;银杏叶、绞股蓝、田基黄益气健脾,化痰止咳,清热解毒;银杏叶、绞股蓝、黄精、枸杞以扶正健脾益肾,提高机体免疫力。诸药合用对降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度具良好作用疗效,无毒副作用。
下面对本发明中使用的各种中药药用性能进行简要介绍
桑叶:疏散风热,清肺润燥,平抑肝阳,清肝明目。
荷叶蒂:固精止带,补脾止泻,益肾养心,降血脂。
海藻:消痰软坚,利水消肿。褐藻酸硫酸酯有抗高血脂症作用。
昆布:消痰软坚,利水消肿。
桂枝:发汗解肌,温通经脉,助阳化气,既可温扶脾阳以助运水,又可温肾阳、逐寒邪以助膀胱气化,而行水湿痰饮之邪,为治疗痰饮病、蓄水证的常用药。
紫苏:解表散寒,行气宽中,能行气以宽中除胀,和胃止呕。
柴胡:具有镇静、安定、镇痛、解热、镇咳等广泛的中枢抑制作用。柴胡及其有效成分柴胡皂苷有抗炎作用,其抗炎作用与促进肾上腺皮质***功能等有关。柴胡皂苷又有降低血浆胆固醇作用。柴胡有较好的抗脂肪肝、抗肝损伤、利胆、降转氨酶、兴奋肠平滑肌、抑制胃酸分泌、抗溃疡、抑制胰蛋白酶等作用。柴胡煎剂对结核杆菌有抑制作用。
决明子:渗湿,健脾。本品有降低血浆总胆固醇和甘油三脂的作用;其注射液可使小鼠胸腺萎缩,对吞噬细胞吞噬功能有增强作用;其所含蒽醌类物质有缓和的泻下作用;其醇浸出液除去醇后,对金黄色葡萄球菌、白色葡萄球菌、桔色葡萄球菌、白喉杆菌、巨大芽孢杆菌、伤寒杆菌、副伤寒杆菌、乙型副伤寒杆菌及大肠杆菌均有抑制作用;其水浸液对皮肤真菌有不同程度的抑制作用。
薏米:利水消肿,渗湿,健脾,除痹,清热排脓,薏苡仁煎剂、醇及丙酮提取物对癌细胞有明显抑制作用。薏苡仁内酯对小肠有抑制作用。其脂肪油能使血清钙、血糖量下降,并有解热、镇静、镇痛作用。
泽泻:利水消肿,渗湿,泄热。对肾炎患者有利尿作用,能增加尿量,增加尿素与氯化物的***,利尿作用更为明显。有降压、降血糖作用,还有抗脂肪肝作用。对金黄色葡萄球菌、肺炎双球菌、结核杆菌有抑制作用。
田基黄:利湿退黄,清热解毒,活血消肿。
枳壳:破气除痞,化痰消积。主治胃肠积滞,湿热泻痢,胸痹,结胸,气滞胸肋疼痛,产后酸痛。
麦芽:消食健胃,回乳消胀。本品又兼能疏肝解郁,常配川楝子、柴胡等,用治肝气郁滞或肝胃不和之胁痛、脘腹痛等。
山楂:消食化积,行气散瘀。主治:积食积滞,泻痢腹痛,疝气痛,瘀阻胸腹痛,痛经。
黄精:补气养阴,健脾,润肺,益肾。黄精能提高机体免疫功能和促进DNA、RNA及蛋白质的合成,促进淋巴细胞转化作用;有增加冠脉流量及降压作用,并能降血脂及减轻冠状动脉粥样硬化程度。
枸杞:滋补肝肾,益精明目。具有免疫调节作用;可提高血睾酮水平,起强壮作用;对造血功能有促进作用;对正常健康人也有显著升白细胞,还有抗衰老、抗突变、抗肿瘤、降血脂、保肝及抗脂肪肝、降血糖、降血压作用。
首乌:补益精血。首乌能使其血中的高胆固醇较快下降至正常水平。首乌中提出的大黄酚能促进肠管运动。
当归:补血调经,活血止痛,润肠通便。
丹参:活血调经,祛瘀止痛,凉血消痈,除烦安神。现代研究能扩张冠脉,增加冠脉血流量,改善心肌缺血,促进心肌缺血或损伤的恢复,缩小心肌梗死范围;能提高耐缺氧能力,对缺氧心肌有保护作用;能改善微循环,促进血液流速;能扩张血管,降低血压。能改善血液流变性,降低血液粘度,抑制血小板和凝血功能,激活纤溶,对抗血栓形成;能保护红细胞膜。能调节血脂,抑制动脉粥样硬化斑块的形成。能保护肝细胞损伤,促进肝细胞再生,有抗肝纤维化作用。能促进骨折和皮肤切口的愈合。能保护胃粘膜、抗胃溃疡。
半夏:燥湿化痰,降逆止呕,消痞散结;外用消肿止痛。
绞股蓝:益气健脾,化痰止咳,清热解毒。绞股蓝及绞股蓝皂苷均具有抗疲劳、抗缺氧、抗高温、抗低温,延长生物体细胞及果蝇、小鼠的寿命,能明显升高SOD活性,降低心、脑、肝细胞内脂褐素的含量,防止正常细胞癌化,提高荷瘤动物免疫力;能明显增加非特异性免疫、细胞免疫、体液免疫的功能,且具免疫调节作用;具有明显的清除氧自由基及抑制或减轻肝细胞变性、坏死及炎症反应;促进肝细胞再生,并有抗肝纤维化的作用,降血脂、降血糖作用,并能提高脾脏、睾丸、大脑和血液蛋白质的合成速率,并具有镇静、催眠、镇痛、增加冠脉流量、抗心肌缺血、增加脑血流量、抑制血栓形成、保肝、抗溃疡等作用。
银杏叶:功能敛肺平喘,活血止痛。用于肺虚咳喘,以及高血脂、高血压、冠心病心绞痛、脑血管痉挛等。
女贞子:滋补肝肾,乌须明目。
郁金:行气化淤、清心解郁、利胆退黄。
方中桑叶、紫苏、柴胡、黄精、女贞子滋补肝肾、疏肝养肝解郁;银杏叶、当归、桂枝、丹参、首乌、郁金行气、活血养血、补益精血;炒麦芽、山楂、枳壳消食化积,理气健脾、化湿和胃;薏米、决明子、海藻、昆布、半夏、泽泻利水消肿,渗湿,泄热,降血脂、改善肝功、改善肝脂肪代谢,有抗脂肪肝作用;银杏叶、绞股蓝、田基黄益气健脾,化痰止咳,清热解毒;银杏叶、绞股蓝、黄精、枸杞以扶正健脾益肾,提高机体免疫力。诸药合用具有清除氧自由基及抑制或减轻肝细胞变性、坏死及炎症反应;促进肝细胞再生,并有抗肝纤维化的作用。具有降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度的疗效。
经临床258人次使用,其中男250人,女8人,年龄28-58岁,病程1-10年,总有效率98.8%,与服用他汀类药物降血脂相比,患者的临床症状、体征消失、肝功能、血脂、血糖及B超各指标明显改善以及总的临床疗效显著,效果明显,无毒副作用。
表1两组治疗后综合疗效对比
组别(例) | 治愈 | 显效 | 好转 | 无效 | 总有效率 |
研究组(258) | 125 | 122 | 8 | 3 | 98.8% |
对照组(200) | 21 | 67 | 58 | 54 | 66.5% |
与对照组治疗后结果对比:P<0.05。
具体实施方式
实施例1:
一种治疗非酒精性脂肪性肝炎的中药,各组分的重量份配比为:桑叶15g、荷叶蒂20g、薏米20g、当归25g、桂枝10g、炒麦芽25g、紫苏15g、柴胡20g,决明子30g、海藻24g、昆布20g、半夏3g、首乌25g、郁金15g、田基黄15g、丹参25g、绞股蓝23g、泽泻15g、黄精24g、山楂18g、枳壳15g、女贞子12g、枸杞15g、银杏叶15g。制成汤剂。
用法:将各原料清洗干净,用冷水下药,浸泡10分钟后上火,武火至沸后用中火煮20分钟,煎煮两遍将汤剂混合,分早晚两次温服。
实施例2:
一种治疗非酒精性脂肪性肝炎的中药,各组分的重量份配比为:桑叶20g、荷叶蒂24g、薏米25g、当归20g、桂枝15g、炒麦芽20g、紫苏12g、柴胡18g、决明子28g、海藻15g、昆布20g、半夏4g、首乌25g、郁金10g、田基黄12g、丹参25g、绞股蓝20g、泽泻12g、黄精24g、山楂15g、枳壳20g、女贞子12g、枸杞12g、银杏叶15g。制成汤剂。
用法:将各原料清洗干净,用冷水下药,浸泡10分钟后上火,武火至沸后用中火煮20分钟,煎煮两遍将汤剂混合,分早晚两次温服。
病例应用:
田某,男,28岁,脂肪性肝炎,肥胖,自觉稍疲乏,平时活动量小,血糖稍高,经用本发明的产品3个月后,好转,B超检查后诊断为肝内仅仅脂肪沉积,血糖正常范围。
实施例3(最佳实施例)
一种治疗非酒精性脂肪性肝炎的中药,各组分的重量份配比为:桑叶25g、荷叶蒂25g、薏米25g、当归25g、桂枝15g、炒麦芽25g、紫苏15g、柴胡20g、决明子30g、海藻25g、昆布20g、半夏3g、首乌25g、郁金15g、田基黄15g、丹参25g、绞股蓝25g、泽泻15g、黄精24g、山楂18g、枳壳25g、女贞子12g、枸杞25g、银杏叶15g。
用法:将各原料清洗干净,用冷水下药,浸泡10分钟后上火,武火至沸后用中火煮20分钟,煎煮两遍将汤剂混合,分早晚两次温服。
病例应用:
高某,男,46岁,脂肪性肝炎,肥胖,自觉疲乏无力,嗜睡、无精神偶感,头痛头晕、头部稍脱发,腹泻、没有一点食欲,B超检查后诊断为脂肪性肝炎,开具上述中药水煎服,每天一剂,连服20天,停10天,开始下一疗程,连服3个月治愈。
Claims (2)
1.一种治疗非酒精性脂肪性肝炎的中药,其特征在于:各组分的质量份配比为:桑叶15-25、荷叶蒂15-25、当归15-25、桂枝8-25、薏米10-25、炒麦芽10-25、紫苏10-15、柴胡10-25、决明子15-30、海藻12-25、昆布12-25、半夏3-5、首乌15-25、郁金8-15、田基黄10-15、丹参15-25、绞股蓝18-25、泽泻10-15、黄精10-24、山楂15-20、枳壳15-25、女贞子12-25、枸杞12-25、银杏叶12-15。
2.根据权利要求1所述的一种治疗非酒精性脂肪性肝炎的中药,其特征在于:各组分的重量份配比为:桑叶25、荷叶蒂25、薏米25、当归25、桂枝15、炒麦芽25、紫苏15、柴胡20、决明子30、海藻25、昆布20,半夏3、首乌25、郁金15、田基黄15、丹参25、绞股蓝25、泽泻15、黄精24、山楂18、枳壳25、女贞子12、枸杞25、银杏叶15。
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CN106109767A (zh) * | 2016-07-13 | 2016-11-16 | 郑亮 | 一种防治非酒精性脂肪性肝病的复方制剂 |
CN109925469A (zh) * | 2017-12-18 | 2019-06-25 | 上海市中医医院 | 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用 |
CN114558099A (zh) * | 2022-03-29 | 2022-05-31 | 沈阳市第六人民医院 | 中药组合物及其制备方法和应用 |
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CN103330865A (zh) * | 2013-07-23 | 2013-10-02 | 邵阳县中医医院 | 一种治疗非酒精性脂肪性肝炎的药物及制备方法 |
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CN103330865A (zh) * | 2013-07-23 | 2013-10-02 | 邵阳县中医医院 | 一种治疗非酒精性脂肪性肝炎的药物及制备方法 |
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CN106109767A (zh) * | 2016-07-13 | 2016-11-16 | 郑亮 | 一种防治非酒精性脂肪性肝病的复方制剂 |
CN109925469A (zh) * | 2017-12-18 | 2019-06-25 | 上海市中医医院 | 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用 |
CN109925469B (zh) * | 2017-12-18 | 2021-07-30 | 上海市中医医院 | 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用 |
CN114558099A (zh) * | 2022-03-29 | 2022-05-31 | 沈阳市第六人民医院 | 中药组合物及其制备方法和应用 |
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