CN105816522A - Traditional Chinese medicine composition for resisting respiratory syncytial virus and preparation method thereof - Google Patents
Traditional Chinese medicine composition for resisting respiratory syncytial virus and preparation method thereof Download PDFInfo
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- CN105816522A CN105816522A CN201510992708.4A CN201510992708A CN105816522A CN 105816522 A CN105816522 A CN 105816522A CN 201510992708 A CN201510992708 A CN 201510992708A CN 105816522 A CN105816522 A CN 105816522A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine composition for resisting a respiratory syncytial virus. The composition is prepared from the following bulk drugs: Saussurea epilobioides, Dracocephalum tanguticum, licorice root, root of large-flowered skullcap and patrinia herb. The invention also discloses a preparation method for the composition. The preparation method comprises a step of mixing alcohol extract of Saussurea epilobioides and Dracocephalum tanguticum with aqueous extract of the licorice root, root of large-flowered skullcap and patrinia herb and a step of preparing a dosage form frequently used in pharmacology. The traditional Chinese medicine composition has strong activity in resisting the respiratory syncytial virus. Results of toxicity test show that the traditional Chinese medicine composition provided by the invention is small in an effective dosage, low in toxicity, free of adverse reaction, safer in usage, low in cost, employs easily available raw materials, can be sustainably developed and has wide application prospects.
Description
Technical field
The present invention relates to Chinese medicine composition and manufacturing technology field thereof, particularly relate to a kind of anti respiratory syncytial virus Chinese medicine composition and preparation method thereof.
Background technology
Respiratory syncytial virus (respiratorysyncytialvirus, RSV) is Paramyxoviridae, the minus-stranded rna virus of pneumonitis virus genus, and its infection is all over the world.RSV is one of main pathogens of Infant Viral Pneumonia and bronchiolitis, easily leaves over long-term abnormal pulmonary function, can induce anaphylaxis and asthma after infection.At present, rsv infection be there is no specific treatment and prevention scheme (Applied Clinical Pediatrics magazine, 2001,16 (13)；176.), many employing specific antibodies are supported therapy clinically, or passive immunotherapy such as uses interferon (IFN) etc., also have employing broad-spectrum antiviral drug such as ribavirin to treat.Though ribavirin is proved to may be used for treating rsv infection, but owing to its toxicity is relatively big, in recent years its curative effect is existed bigger dispute.Chinese medicine is China or even the medical treasure-house in the world, and the disease for the treatment of by Chinese herbs viral infection has had the history of thousand of years.Traditional Chinese Medicine Anti virus is evident in efficacy, and antiviral spectrum is wide, and systemic administration is without obvious histiocyte toxicity, teratogenesis, mutagenesis, immunosuppressant or bone marrow depression, and typically have no drug resistance generation, to persistence and whole and sexy be infected with effect.Therefore, necessary on the basis of prior art, Chinese medicine composition of exploitation a kind of present invention that anti respiratory syncytial virus effect is strong, untoward reaction is little offer and preparation method thereof is provided.
Summary of the invention
It is an object of the invention to provide a kind of anti respiratory syncytial virus Chinese medicine composition and preparation method thereof.
The above-mentioned purpose of the present invention is achieved by techniques below scheme:
A kind of anti respiratory syncytial virus Chinese medicine composition, it is characterised in that be prepared from by following Chinese medicine crude drug: S.epilobioides, tangut dragonhead, Radix Glycyrrhizae, Radix Scutellariae and Herba Patriniae.
Further, described anti respiratory syncytial virus Chinese medicine composition, it is characterised in that be prepared from by the crude drug of following weight proportion: S.epilobioides 10-30 part, tangut dragonhead 10-30 part, Radix Glycyrrhizae 10-20 part, Radix Scutellariae 5-15 part, Herba Patriniae 5-15 part.
Further, described anti respiratory syncytial virus Chinese medicine composition, it is characterised in that its optimum proportioning is to be prepared from by the crude drug of following weight portion: S.epilobioides 20 parts, tangut dragonhead 20 parts, 15 parts of Radix Glycyrrhizae, Radix Scutellariae 10 parts, Herba Patriniae 10 parts.
The preparation method of a kind of anti respiratory syncytial virus Chinese medicine composition, it is characterised in that comprise the following steps:
(1) take the S.epilobioides in described crude drug and tangut dragonhead by weight ratio, be crushed to 60-120 mesh, the ethanol of the 95% of 10 times of volumes of addition, reflux, extract, 2 hours in the water-bath of 60 DEG C, filtering residue repeats to process twice, merging filtrate, filtrate is concentrated, is dried to obtain ethanol extract；
(2) take the Radix Glycyrrhizae in described crude drug, Radix Scutellariae and Herba Patriniae by weight ratio, be crushed to 60-120 mesh, add the water soaking 10 hours of 10 times of volumes of people, again with 8 times of soak by water 30 minutes, merging filtrate after negative pressure leaching after decocting 1 hour, it is evaporated under reduced pressure and concentrates, be dried and to obtain water extract；
(3) step (1) gained ethanol extract and step (2) gained water extract are pulverized and mix homogeneously makes pharmaceutically common formulations.
Described pharmaceutically common formulations is granule, tablet or capsule.
The anti respiratory syncytial virus Chinese medicine composition that the present invention provides has the advantage that
Anti respiratory syncytial virus activity is strong, and shows through toxicity test result, and the effective dose that the present invention provides is less, and toxicity is little, has no adverse reaction, and uses safer, and raw material is easy to get, and cost is relatively low, Sustainable Exploitation, and application prospect is extensive.
Detailed description of the invention
Further illustrate the essentiality content of the present invention below in conjunction with embodiment, but do not limit scope with this.Although the present invention being explained in detail with reference to preferred embodiment, it will be understood by those within the art that, technical scheme can be modified or equivalent, without deviating from the spirit and scope of technical solution of the present invention.
Embodiment 1
Take crude drug S.epilobioides 20 grams, tangut dragonhead 20 grams, 15 grams of Radix Glycyrrhizae, Radix Scutellariae 10 grams, Herba Patriniae 10 grams respectively；
(1) acquired crude drug S.epilobioides 20 grams and tangut dragonhead gram are mixed, be crushed to 60-120 mesh, the ethanol of the 95% of 10 times of volumes of addition, reflux, extract, 2 hours in the water-bath of 60 DEG C, filtering residue repeats to process twice, merging filtrate, filtrate is concentrated, is dried to obtain ethanol extract；
(2) by 15 grams of acquired crude drug Radix Glycyrrhizae, Radix Scutellariae 10 grams and Herba Patriniae 10 grams mixing, it is crushed to 60-120 mesh, add the water soaking 10 hours of 10 times of volumes of people, again with 8 times of soak by water 30 minutes, merging filtrate after negative pressure leaching after decocting 1 hour, it is evaporated under reduced pressure and concentrates, be dried and to obtain water extract；
(3) step (1) gained ethanol extract and step (2) gained water extract are pulverized and mix homogeneously makes granule.
Experimental example 1
1, reagent and instrument
DMEM culture medium, adjusts pH to 7.0～7.2 with sodium bicarbonate after aseptic filtration；New-born calf serum, Hangzhou Ilex purpurea Hassk.[I.chinensis Sims, through 56 DEG C, 30min inactivates complement, degerming subpackage；Maintaining liquid is the DMEM culture medium containing 2% calf serum；96 well culture plates；CO2 incubator；Superclean bench；Inverted microscope.
People's larynx epidermal carcinoma cell Hep-2 cell；Respiratory syncytial virus (RSV, Long strain) separates strain.
2, Experimental agents
The Chinese medicine composition DMSO obtained in experimental example 1 is diluted to 100 μ g/ μ L stock solutions standby.
3, virus titer measures
The strain activated is made 10 times of serial dilutions, 10-1～10-9, conventional method infects fine and close monolayer Hep-2 cell, every hole 100 μ l, if 8 multiple holes, sets normal cell controls simultaneously, 34.5 DEG C, 5%CO2 incubator cultivates 4d, every day observation of cell pathological changes effect (CPE) situation, CPE degree can be divided into from "+"～" ++++".
4, medicine is to Hep-2 cytotoxic assay
By the Hep-2 cell after trypsinization, it is inoculated in 96 well culture plates with 5 × 103/hole density, 37 DEG C, after 5%CO2 cultivates 24h, abandon liquid, 6 series concentration (initial concentration is 500 μ g/ml) are become to add 96 orifice plates medicine doubling dilution by the DMEM culture medium containing chicken serum 2.5%, 100 μ l/ holes, each dilution factor sets 3 multiple holes, sets normal cell controls group simultaneously, after continuing to cultivate 48h, observe and record medicine and act on maximal non-toxic concentration TC0 of cell.
5, the pharmacodynamic experiment method of Antiviral Effect and result
The RSV virus liquid of 100TCID50 is inoculated in the Hep-2 cell growing up to monolayer, every hole 50 μ l, and in the range of medicine non-toxic concn, add the Tibetan medicine extract containing variable concentrations and the maintenance liquid of ribavirin, every hole 50 μ l, each dosage group repeats 3 holes, in 34.5 DEG C, the continuation cultivation of 5%CO2 incubator.Set normal cell controls, virus control simultaneously.Every day is observation of cell form under inverted microscope, reaches 75% with virus control group CPE, and is laboratory observation terminal when cell controls is normal, records each hole CPE degree.Result is as shown in the table:
Table 1 ribavirin anti-RSV pharmacodynamic experiment result
| Sample μ g ml-1 | 500 | 250 | 125 | 62.5 | 31.25 | 15.625 |
| Ribavirin | - | - | - | - | + | + |
"-" represents does not has pathological changes, 0%～25% be "+"
Table 2 Chinese medicine composition anti-RSV pharmacodynamic experiment result
| Sample μ g ml-1 | 500 | 250 | 125 | 62.5 | 31.25 | 15.625 |
| Chinese medicine composition | - | - | - | + | ++ | +++ |
"-" represents does not has pathological changes；0%～25% be "+"；26%～50% is " ++ "；51%～75% is " +++ "；76%～100% be " ++++"；RSV matched group is " +++ "；Cell controls group is "-"
In antiviral activity is tested, there is not pathological changes in Hep-2 cell controls, and positive control agents Ribavirin has the effect substantially suppressing RSV when 3.125 μ g/ml concentrations above.Along with the increase of embodiment 1 Chinese medicine composition substrate concentration, Hep-2 cytopathy (refers to the cytopathy that virus causes；Cell becomes big, merges, and comes off and forms plaque) degree gradually weaken, when drug level reaches 125 μ g/ml, cytopathy is totally constrained, and i.e. Chinese medicine composition substrate concentration completely inhibits the valid density of RSV propagation in vitro is 125 more than μ g/ml.
Embodiment 2
Take crude drug S.epilobioides 10 grams, tangut dragonhead 10 grams, 10 grams of Radix Glycyrrhizae, Radix Scutellariae 5 grams, Herba Patriniae 5 grams respectively；
(1) acquired crude drug S.epilobioides 20 grams and tangut dragonhead gram are mixed, be crushed to 60-120 mesh, the ethanol of the 95% of 10 times of volumes of addition, reflux, extract, 2 hours in the water-bath of 60 DEG C, filtering residue repeats to process twice, merging filtrate, filtrate is concentrated, is dried to obtain ethanol extract；
(2) by 15 grams of acquired crude drug Radix Glycyrrhizae, Radix Scutellariae 10 grams and Herba Patriniae 10 grams mixing, it is crushed to 60-120 mesh, add the water soaking 10 hours of 10 times of volumes of people, again with 8 times of soak by water 30 minutes, merging filtrate after negative pressure leaching after decocting 1 hour, it is evaporated under reduced pressure and concentrates, be dried and to obtain water extract；
(3) step (1) gained ethanol extract and step (2) gained water extract are pulverized and mix homogeneously makes tablet.
Embodiment 3
Take crude drug S.epilobioides 30 grams, tangut dragonhead 30 grams, 20 grams of Radix Glycyrrhizae, Radix Scutellariae 15 grams, Herba Patriniae 15 grams respectively；
(1) acquired crude drug S.epilobioides 20 grams and tangut dragonhead gram are mixed, be crushed to 60-120 mesh, the ethanol of the 95% of 10 times of volumes of addition, reflux, extract, 2 hours in the water-bath of 60 DEG C, filtering residue repeats to process twice, merging filtrate, filtrate is concentrated, is dried to obtain ethanol extract；
(2) by 15 grams of acquired crude drug Radix Glycyrrhizae, Radix Scutellariae 10 grams and Herba Patriniae 10 grams mixing, it is crushed to 60-120 mesh, add the water soaking 10 hours of 10 times of volumes of people, again with 8 times of soak by water 30 minutes, merging filtrate after negative pressure leaching after decocting 1 hour, it is evaporated under reduced pressure and concentrates, be dried and to obtain water extract；
(3) step (1) gained ethanol extract and step (2) gained water extract are pulverized and mix homogeneously makes tablet.
The effect of above-described embodiment indicates that the essentiality content of the present invention, but does not limit protection scope of the present invention with this.It will be understood by those within the art that, technical scheme can be modified or equivalent, without deviating from essence and the protection domain of technical solution of the present invention.
Claims (5)
1. an anti respiratory syncytial virus Chinese medicine composition, it is characterised in that be prepared from by following Chinese medicine crude drug: S.epilobioides, tangut dragonhead, Radix Glycyrrhizae, Radix Scutellariae and Herba Patriniae.
2. a kind of anti respiratory syncytial virus Chinese medicine composition as claimed in claim 1, it is characterised in that be prepared from by the crude drug of following weight proportion: S.epilobioides 10-30 part, tangut dragonhead 10-30 part, Radix Glycyrrhizae 10-20 part, Radix Scutellariae 5-15 part, Herba Patriniae 5-15 part.
3. a kind of anti respiratory syncytial virus Chinese medicine composition as claimed in claim 2, it is characterised in that its optimum proportioning is to be prepared from by the crude drug of following weight portion: S.epilobioides 20 parts, tangut dragonhead 20 parts, 15 parts of Radix Glycyrrhizae, Radix Scutellariae 10 parts, Herba Patriniae 10 parts.
4. the preparation method of a kind of anti respiratory syncytial virus Chinese medicine composition as described in arbitrary in claim 1-3, it is characterised in that comprise the following steps:
(1) take the S.epilobioides in described crude drug and tangut dragonhead by weight ratio, be crushed to 60-120 mesh, the ethanol of the 95% of 10 times of volumes of addition, reflux, extract, 2 hours in the water-bath of 60 DEG C, filtering residue repeats to process twice, merging filtrate, filtrate is concentrated, is dried to obtain ethanol extract；
(2) take the Radix Glycyrrhizae in described crude drug, Radix Scutellariae and Herba Patriniae by weight ratio, be crushed to 60-120 mesh, add the water soaking 10 hours of 10 times of volumes of people, again with 8 times of soak by water 30 minutes, merging filtrate after negative pressure leaching after decocting 1 hour, it is evaporated under reduced pressure and concentrates, be dried and to obtain water extract；
(3) step (1) gained ethanol extract and step (2) gained water extract are pulverized and mix homogeneously makes pharmaceutically common formulations.
The preparation method of described a kind of anti respiratory syncytial virus Chinese medicine composition the most as claimed in claim 4, it is characterised in that described pharmaceutically common formulations is granule, tablet or capsule.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288930A (en) * | 2021-04-25 | 2021-08-24 | 山东中医药大学 | In-vivo and in-vitro anti-RSV effective part of liquorice and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288930A (en) * | 2021-04-25 | 2021-08-24 | 山东中医药大学 | In-vivo and in-vitro anti-RSV effective part of liquorice and preparation method and application thereof |
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