CN105816156B - A kind of the conductivity magnetosonic imaging device and imaging method of combination thermoacoustic effect signal - Google Patents
A kind of the conductivity magnetosonic imaging device and imaging method of combination thermoacoustic effect signal Download PDFInfo
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Abstract
A kind of the conductivity magnetosonic imaging device and imaging method of combination thermoacoustic effect signal, device consider influence of the thermoacoustic effect sound source to acoustical signal in magnetosonic coupling imaging.The generation of magnetosonic coupling effect signal is to be acted on by Lorentz force by loading alternating excitation magnetic field in steady magnetic field and generate what once per revolution vibration was realized.Thermoacoustic effect signal is to act on biological tissue by the excitation field of alternation, and electromagnetic wave absorption causes to thermally expand the vibration generated.Method only uses the signal detection and sample conductivity imaging that a set of imaging device realizes two kinds of effects, sample is placed in magnetostatic field, under the conditions of adding magnetostatic field and being not added with two kinds of magnetostatic field, apply the pulse excitation magnetic field of adjustable amplitude and frequency, realizes the acquisition of magneto-acoustic effect signal and thermoacoustic effect signal.The present invention merges the conductivity information of the conductivity information and magnetoacoustic signals reflection of hot reflected acoustic signal, further realizes Exact Reconstruction biological tissue distribution of conductivity image.
Description
Technical field
The present invention relates to a kind of magnetosonic imaging device and imaging methods.More particularly to a kind of combination thermoacoustic effect signal
Conductivity magnetosonic imaging device and imaging method.
Background technology
For tumor tissues in the change for having not occurred form, electrical characteristics have occurred that variation, if can extract
The electrical property change information of lesion early stage provides possibility for the early detection of disease.Therefore, noninvasive, safety, knot are constituted
The imaging technique that picture and functional imaging are combined increasingly receives significant attention.
Magnetosonic imaging is the method for new bio tissue electrical characteristics imaging.Magnetosonic imaging is to encourage tissue by foreign current
Internal charged ion, while under the action of magnetostatic field, organization internal conductivity information is converted into acoustical signal.Thermoacoustic signal
It is to input imaging organization internal generation induced current by alternating magnetic field to be extracted from acoustical signal by joule thermal excitation acoustical signal
Heat absorption coefficients distributed intelligence carries out electrical characteristics imaging to tissue.
The acoustical signal obtained in the magnetosonic imaging of existing apparatus is vibrated from not only caused by Lorentz force, also source
It is vibrated in the thermoacoustic effect of no steady magnetic field, only pulsed magnetic field action.Therefore, the so-called magnetosonic letter that sonic transducer receives
Number it is the superposition for the acoustical signal that both sound sources generate, it is used at present to be based on since both sound sources are all related to conductivity
The conductivity algorithm for reconstructing of lorentz force density divergence sound source design, does not account for shadow of the thermoacoustic effect sound source to acoustical signal
It rings, to the feature description of acoustical signal with image reconstruction as a result, being had differences with the acoustical signal and distribution of conductivity being an actually-received.
Invention content
The technical problem to be solved by the invention is to provide one kind capable of realizing Exact Reconstruction biological tissue distribution of conductivity
The conductivity magnetosonic imaging device and imaging method of the combination thermoacoustic effect signal of image.
The technical solution adopted in the present invention is：A kind of conductivity magnetosonic imaging device of combination thermoacoustic effect signal, packet
It includes, couplant slot, is respectively arranged in the couplant slot：It is used to support the pallet of sample, is connected to the bottom of the pallet
The stepper motor for driving pallet to rotate is held, the first sonic transducer and rising tone transducing of the sample both sides are separately positioned on
Device, wherein the input terminal of the stepper motor connects the driving circuit controlled by computer by the conducting wire through couplant slot,
The signal output end of first sonic transducer and the second sonic transducer is all connected with the signal input part of binary channels preamplifier,
The signal output end of the binary channels preamplifier connects computer by capture card, is additionally provided with above the sample sharp
Coil is encouraged, the excitation coil connects exciting bank, and the top of the excitation coil is also provided with static magnet by mobile holder.
The exciting bank includes the signal generator for being used to generate pumping signal being connected and is used for described
The power amplifier that is amplified of pumping signal, the output end connection of the power amplifier excitation coil.
The static magnet is arranged in the top of the excitation coil by the mobile holder that can be moved.
A kind of imaging method of the conductivity magnetosonic imaging device of combination thermoacoustic effect signal, includes the following steps：
1) by acting on sample to be tested in the pulsed sinusoidal driving voltage to excitation coil of exciting bank output frequency 1MHz；
2) the first sonic transducer and the second sonic transducer are passed through by the binary channels preamplifier of high cmrr respectively
Acquire the magnetoacoustic signals and thermoacoustic signal of sample to be tested；
3) to carrying out filtering and noise reduction processing after collected sound signal digital；
4) it uses Time-Frequency Analysis Method to carry out frequency-domain analysis to thermoacoustic signal, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, magnetosonic is removed using wave digital lowpass filter
Thermoacoustic signal in signal, isolates single magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, magnetosonic source acoustic pressure wave equation is establishedTime backprojection algorithm is based on again to rebuild using single magnetoacoustic signals
The conductivity of sample to be tested；
7) using the thermoacoustic sound source based on Joule heat as source item, the acoustic pressure wave equation in thermoacoustic source is establishedIt is waited for again using thermoacoustic signal reconstruction based on time backprojection algorithm
The conductivity of test sample sheet；
8) fusion steps 6) what is obtained rebuilds conductivity and the obtained utilization of step 7) of sample to be tested using magnetoacoustic signals
The conductivity of thermoacoustic signal reconstruction sample to be tested obtains sample distribution of conductivity image.
In step 2) when detecting magnetoacoustic signals, under conditions of loading magnetostatic field, apply the arteries and veins of adjustable amplitude and frequency
Impulse, which is encouraged, acts on excitation coil, and the magnetoacoustic signals of sample to be tested are acquired using the ultrasonic transducer of centre frequency 1MHz；
In step 2) when detecting thermoacoustic signal, static magnet is removed by moveable holder, is being not loaded with magnetostatic field
Under the conditions of, the pulse excitation for applying adjustable amplitude and frequency acts on excitation coil, using the super of 200~500kHz of centre frequency
Sonic transducer acquires the thermoacoustic signal of sample to be tested.
The conductivity magnetosonic imaging device and imaging method of a kind of combination thermoacoustic effect signal of the present invention consider thermoacoustic effect
The influence of sound source is answered, the acoustical signal that two kinds of sound sources of magnetosonic and thermoacoustic propagate to body surface sensing station is obtained.Utilize two kinds of sound sources
Establish acoustic pressure wave equation respectively for source item, solution obtains the acoustical signal feature of two kinds of sound sources, separately designs magnetoacoustic signals and heat
The reconstruction conductivity algorithm of acoustical signal, to tissue conductivities accurate reconstruction.Merge the conductivity information and magnetic of hot reflected acoustic signal
The conductivity information of reflected acoustic signal further realizes Exact Reconstruction biological tissue distribution of conductivity image.
Description of the drawings
Fig. 1 is the structural schematic diagram for the conductivity magnetosonic imaging device that the present invention combines thermoacoustic effect signal；
Fig. 2 is the imaging method flow chart for the conductivity magnetosonic imaging device that the present invention combines thermoacoustic effect signal.
In figure
1：Couplant slot 2：Pallet
3：Sample 4：Stepper motor
5：Driving circuit 6：Computer
7：Capture card 8：Binary channels preamplifier
9：First sonic transducer 10：Second sonic transducer
11：Exciting bank 12：Excitation coil
13：Static magnet 14：Mobile holder
Specific implementation mode
Dress is imaged to a kind of conductivity magnetosonic of combination thermoacoustic effect signal of the present invention with reference to embodiment and attached drawing
It sets and imaging method is described in detail.
The conductivity magnetosonic imaging device of a kind of combination thermoacoustic effect signal of the present invention, it is contemplated that in magnetosonic coupling imaging
Influence of the thermoacoustic effect sound source to acoustical signal.The generation of magnetosonic coupling effect signal is handed over by being loaded in steady magnetic field
Become excitation field, is acted on by Lorentz force and generate what once per revolution vibration was realized.Thermoacoustic effect signal is the excitation by alternation
In biological tissue, electromagnetic wave absorption causes to thermally expand the vibration generated magnetic fields.It is real that the present invention only uses a set of imaging device
The signal detection of existing two kinds of effects and sample conductivity imaging, being included in has under magnetic field conditions the detection of magnetoacoustic signals and without magnetic field
In the case of thermoacoustic signal detection.Sample is placed on pallet, under the conditions of adding magnetostatic field and being not added with two kinds of magnetostatic field, application can
The acquisition of magnetoacoustic signals and thermoacoustic effect signal is realized in the pulse excitation magnetic field of amplitude modulation value and frequency.Algorithm for design is to acquisition
Signal is respectively processed, and merges the sample conductivity information of two kinds of effect reflected acoustic signals, realizes sample boundary and inside electricity
Conductance distribution is rebuild, and improves the accuracy of conductivity reconstruction to a certain extent.
As shown in Figure 1, a kind of conductivity magnetosonic imaging device of combination thermoacoustic effect signal of the present invention, including, coupling
Agent slot 1 is respectively arranged in the couplant slot 1：It is used to support the pallet 2 of sample 3, is connected to the bottom end of the pallet 2
Stepper motor 4 for driving pallet 2 to rotate, the first sonic transducer 9 and the rising tone for being separately positioned on 3 both sides of the sample change
Energy device 10, wherein the input terminal of the stepper motor 4 connects the drive controlled by computer 6 by the conducting wire through couplant slot 1
Dynamic circuit 5, the signal output end of first sonic transducer, 9 and second sonic transducer 10 are all connected with binary channels preamplifier 8
Signal input part, the signal output end of the binary channels preamplifier 8 passes through capture card 7 and connects computer 6, the sample
3 top is additionally provided with excitation coil 12, and the excitation coil 12 connects exciting bank 11, and the exciting bank 11 includes
Be connected for generating the signal generator 111 of pumping signal and the power for being amplified to the pumping signal is put
The output end of big device 112, the power amplifier 112 connects the excitation coil 12.The top of the excitation coil 12 is also
It is provided with static magnet 13.
The static magnet 13 is arranged in the top of the excitation coil 12 by the mobile holder 14 that can be moved, from
And load magnetostatic field may be implemented and be not loaded with the different condition of magnetostatic field.Static magnet is moved by moveable holder, is being added
Under conditions of carrying magnetostatic field, apply the pulse excitation magnetic field of adjustable amplitude and frequency to sample to be tested, realizes magneto-acoustic effect sound letter
Number acquisition.Static magnet is moved by moveable holder, under conditions of being not loaded with magnetostatic field, sample to be tested is applied adjustable
The acquisition of thermoacoustic effect acoustical signal is realized in the pulse excitation magnetic field of amplitude and frequency.
First sonic transducer 9 and the second sonic transducer 10 are staggered relatively, while receiving acoustical signal, 9 He of the first sonic transducer
The centre frequency of second sonic transducer 10 is designed according to the requirement of sample conductivity reconstruction information.When measuring biological tissue, the
One sonic transducer, 9 centre frequency is selected as the 1MHz with driving pulse with frequency, and 10 centre frequency of the second sonic transducer is selected as 200~
500kHz。
The present invention a kind of combination thermoacoustic effect signal conductivity magnetosonic imaging device imaging method, theoretical foundation
It is：
According to magnetosonic coupling effect acoustic pressure wave equation：
Wherein, p (r, t) is that magnetosonic couples acoustical signal, and J is current density, is conductivity according to Ohm's law J=σ E, σ,
B0For magnetostatic field, csFor the velocity of sound in medium.
According to thermoacoustic coupling effect acoustic pressure wave equation:
Wherein, p (r, t) is that thermoacoustic couples acoustical signal, and β is coefficient of thermal expansion, CpFor normal pressure thermal capacitance.
From in equation (1) as it can be seen that magnetosonic couple acoustical signal in can reflect conductivity boundary position information, from equation
(2) as it can be seen that thermoacoustic effect acoustical signal can embody internal conductance rate distributed intelligence in.
As shown in Fig. 2, a kind of imaging method of the conductivity magnetosonic imaging device of combination thermoacoustic effect signal of the present invention,
The signal of acquisition is handled, the sample conductivity letter of two kinds of reflected acoustic signals of corresponding algorithm fusion magnetosonic and thermoacoustic is designed
Breath realizes that sample boundary and the distribution of internal conductance rate are rebuild, i.e. conductivity information and magnetosonic by merging hot reflected acoustic signal
The conductivity information of signal reflection, further realizes Exact Reconstruction biological tissue distribution of conductivity image.Specifically include following step
Suddenly：
1) by acting on sample to be tested in the pulsed sinusoidal driving voltage to excitation coil of exciting bank output frequency 1MHz；
2) the first sonic transducer and the second sonic transducer are passed through by the binary channels preamplifier of high cmrr respectively
Acquire the magnetoacoustic signals and thermoacoustic signal of sample to be tested；
When detecting magnetoacoustic signals, under conditions of loading magnetostatic field, the pulse excitation for applying adjustable amplitude and frequency is made
Excitation coil is used, the magnetoacoustic signals of sample to be tested are acquired using the ultrasonic transducer of centre frequency 1MHz.
When detecting thermoacoustic signal, static magnet is removed by moveable holder, under conditions of being not loaded with magnetostatic field, is applied
Add the impulse action of adjustable amplitude and frequency to excitation coil, is acquired using the ultrasonic transducer of 200~500kHz of centre frequency
The thermoacoustic signal of sample to be tested.
3) to carrying out filtering and noise reduction processing after collected sound signal digital；
4) it uses Time-Frequency Analysis Method to carry out frequency-domain analysis to thermoacoustic signal, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, magnetosonic is removed using wave digital lowpass filter
Thermoacoustic signal in signal, isolates single magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, the acoustic pressure wave equation in magnetosonic source is establishedTime backprojection algorithm is based on again to rebuild using single magnetoacoustic signals
The conductivity of sample to be tested；
7) using the thermoacoustic sound source based on Joule heat as source item, the acoustic pressure wave equation in thermoacoustic source is establishedIt is waited for again using thermoacoustic signal reconstruction based on time backprojection algorithm
The conductivity of test sample sheet；
8) fusion steps 6) what is obtained rebuilds conductivity and the obtained utilization of step 7) of sample to be tested using magnetoacoustic signals
The conductivity of thermoacoustic signal reconstruction sample to be tested obtains sample distribution of conductivity image.
Example is given below：
1) sample to be tested 3 is fixed below the excitation coil in device as shown in Figure 1,1 top of couplant slot passes through shifting
Dynamic holder 14 places the uniform magnetic field of the formation of static magnet 13 perpendicular to sample holding plane, and the first sonic transducer 9 and the rising tone change
Energy device 10 is symmetrically disposed at 3 plane both sides of sample in the horizontal direction；
2) it when detecting thermoacoustic signal, using the sinusoidal impulse voltage drive sample of 1MHz frequencies, is moved by mobile holder 14
The effect that static magnet 13 removes homogeneous static magnetic field is walked, with the first of the second sonic transducer of centre frequency 200-500kHz and 1MHz
Sonic transducer acquires signal, and signal is received using binary channels preamplifier 8, and controlling motor drive by computer is placed with sample
3 pallet 2 rotates, and making the first sonic transducer 9 and the second sonic transducer 10, circumferentially scan mode acquires signal point by point, obtains each
The thermoacoustic signal of sample 3 at collection point；
3) it when detecting magnetoacoustic signals, using the sinusoidal impulse voltage drive sample of 1MHz frequencies, is moved by mobile holder 14
For sound magnet 13 to the underface of sample 3, the intensity that magnetostatic field is arranged is 1T, while with the of 200~500kHz of centre frequency
The first sonic transducer of two sonic transducers and 1MHz acquire signal, receive signal using binary channels preamplifier, pass through calculating
Machine control motor drives the pallet 2 for being placed with sample 3 to rotate, and the first sonic transducer 9 and the second sonic transducer 10 is made circumferentially to scan
Mode acquires signal point by point, obtains the magnetoacoustic signals of sample 3 at each collection point；
4) it uses Time-Frequency Analysis Method to carry out frequency-domain analysis to 10 collected thermoacoustic signal of second transducer, obtains thermoacoustic
The frequency domain characteristic of signal；Wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, is gone using wave digital lowpass filter
Except the thermoacoustic signal in magnetoacoustic signals, single magnetoacoustic signals are isolated；
5) equation is solved
Obtain the algorithm of thermoacoustic signal reconstruction conductivity；The thermoacoustic signal data input algorithm that step 2) is obtained obtains heat
The tested sample distribution of conductivity that acoustic effect is rebuild；
6) equation is solved
It obtains acoustic pressure caused by two kinds of sound sources and fluctuates non trivial solution, the single magnetoacoustic signals data that step 4) is obtained input
Algorithm obtains the lower tested sample distribution of conductivity rebuild of magneto-acoustic effect effect；
7) the distribution of conductivity figure rebuild by step 5) and 6) carries out location position and merges, and obtains sample conductivity variations
The distributed image on boundary and interior location improves accuracy and integrality that conductivity is rebuild.
In the case that this method and step are equally applicable to driving pulse as other frequencies, it is not limited only to 1MHz.At this point, the
The centre frequency of one sonic transducer should be consistent with driving pulse frequency.When measuring biological tissue, 10 center of the second sonic transducer
Frequency is selected as 200~500kHz.
Claims (6)
1. a kind of conductivity magnetosonic imaging device of combination thermoacoustic effect signal, including, couplant slot (1), which is characterized in that institute
It is respectively arranged in the couplant slot (1) stated：It is used to support the pallet (2) of sample (3), is connected to the bottom end of the pallet (2)
The first sonic transducer (9) in the sample (3) side and setting is arranged in stepper motor (4) for driving pallet (2) to rotate
The second sonic transducer (10) in the sample (3) other side, wherein the input terminal of the stepper motor (4) is by running through coupling
The conducting wire of mixture slot (1) connects the driving circuit (5) controlled by computer (6), and first sonic transducer (9) and the rising tone change
The signal output end of energy device (10) is all connected with the signal input part of binary channels preamplifier (8), the preposition amplification of binary channels
The signal output end of device (8) connects computer (6) by capture card (7), and excitation coil is additionally provided with above the sample (3)
(12), the top of excitation coil (12) the connection exciting bank (11), the excitation coil (12) also passes through mobile holder
(14) it is provided with static magnet (13).
2. a kind of conductivity magnetosonic imaging device of combination thermoacoustic effect signal according to claim 1, which is characterized in that
The exciting bank (11) includes the signal generator (111) for being used to generate pumping signal being connected and is used for described
The power amplifier (112) that is amplified of pumping signal, the output end connection of the power amplifier (112) excitation
Coil (12).
3. a kind of conductivity magnetosonic imaging device of combination thermoacoustic effect signal according to claim 1, which is characterized in that
The static magnet (13) is top of mobile holder (14) setting by that can move in the excitation coil (12).
4. a kind of imaging method of the conductivity magnetosonic imaging device of combination thermoacoustic effect signal described in claim 1, special
Sign is, includes the following steps：
1) by acting on sample to be tested in the pulsed sinusoidal driving voltage to excitation coil of exciting bank output frequency 1MHz；
2) it is acquired respectively by the first sonic transducer and the second sonic transducer by the binary channels preamplifier of high cmrr
The magnetoacoustic signals and thermoacoustic signal of sample to be tested；
3) to carrying out filtering and noise reduction processing after collected sound signal digital；
4) it uses Time-Frequency Analysis Method to carry out frequency-domain analysis to thermoacoustic signal, obtains the frequency domain characteristic of thermoacoustic signal；
5) wave digital lowpass filter is designed according to the frequency domain characteristic of thermoacoustic signal, magnetoacoustic signals is removed using wave digital lowpass filter
In thermoacoustic signal, isolate single magnetoacoustic signals；
6) using the magnetosonic sound source based on Lorentz force as source item, magnetosonic source acoustic pressure wave equation is establishedTime backprojection algorithm is based on again to rebuild using single magnetoacoustic signals
The conductivity of sample to be tested；
7) using the thermoacoustic sound source based on Joule heat as source item, the acoustic pressure wave equation in thermoacoustic source is establishedIt is waited for again using thermoacoustic signal reconstruction based on time backprojection algorithm
The conductivity of test sample sheet；
8) fusion steps 6) what is obtained rebuilds the conductivity and the obtained utilization thermoacoustic of step 7) of sample to be tested using magnetoacoustic signals
The conductivity of signal reconstruction sample to be tested obtains sample distribution of conductivity image.
5. the imaging method of the conductivity magnetosonic imaging device of combination thermoacoustic effect signal according to claim 4, special
Sign is, in step 2) when detecting magnetoacoustic signals, under conditions of loading magnetostatic field, applies the pulse of adjustable amplitude and frequency
Incentive action acquires the magnetoacoustic signals of sample to be tested using the ultrasonic transducer of centre frequency 1MHz in excitation coil；
6. the imaging method of the conductivity magnetosonic imaging device of combination thermoacoustic effect signal according to claim 4, special
Sign is, in step 2) when detecting thermoacoustic signal, static magnet is removed by moveable holder, in the item for being not loaded with magnetostatic field
Under part, the pulse excitation for applying adjustable amplitude and frequency acts on excitation coil, using the ultrasound of 200~500kHz of centre frequency
Energy converter acquires the thermoacoustic signal of sample to be tested.
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