CN105796699A - Processing method and application of cape jasmine fruits - Google Patents
Processing method and application of cape jasmine fruits Download PDFInfo
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- CN105796699A CN105796699A CN201610215371.0A CN201610215371A CN105796699A CN 105796699 A CN105796699 A CN 105796699A CN 201610215371 A CN201610215371 A CN 201610215371A CN 105796699 A CN105796699 A CN 105796699A
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- fructus gardeniae
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- concocting method
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a processing method and an application of cape jasmine fruits. The method comprises the steps as follows: cape jasmine fruits are exposed to the sun and treated with an ethanol solution and an acetone solution in a volume ratio being 15:1; frying is performed at a temperature of 150-200 DEG C and at a rotary speed of 15 r/min. Compared with a traditional processing method, the processing method has the advantages that the content of effective medicine components obtained by smashing and ethanol extraction of the fried cape jasmine fruits is greatly increased; the processing method of the cape jasmine fruits is easy to operate and suitable for being popularized.
Description
Technical field
The present invention relates to Chinese medicine processing technical field, particularly relate to a kind of Fructus Gardeniae processing technique and application thereof.
Background technology
Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae, for the heat clearing and fire purging medicine that clinic is conventional, has pathogenic fire purging and removes
Tired, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body, at present for active ingredient contained in Fructus Gardeniae and content, do not have strict regulation,
" Chinese Pharmacopoeia " version in 2000 only specifies the sweet content limit of Fructus Gardeniae in Fructus Gardeniae, and Fructus Gardeniae content must not be less than 1.8%, and Fructus Gardeniae Preparatus contains
Amount must not be less than 1%, and " content of α-crocetin in Fructus Gardeniae is that index is only for controlling Fructus Gardeniae decoction pieces by Chinese Pharmacopoeia 2005
Quality, this concocting method allowing for Fructus Gardeniae is various, and the quality of the process of preparing Chinese medicine judges the most by rule of thumb, without objective quality standard so that
During the process of preparing Chinese medicine, end product quality is difficult to consistent, also result in various places processed products of Fructus Gardeniae mass difference very big simultaneously, clinical practice confusion
Phenomenon.
In Fructus Gardeniae, contained active ingredient mainly has that Fructus Gardeniae is sweet, α-crocetin, tannin, ursolic acid, Fructus Gardeniae is sweet have slow let out, town
Bitterly, antiinflammatory and reduce the effect such as pancreatic amylase, α-crocetin is a kind of novel medicine with preventing and treating cardiovascular system diseases effect
Thing, tannin then has astringing to arrest bleeding effect, and ursolic acid has calmness, antiinflammatory, the effect such as antibacterial.
The difference of processing procedure, in Fructus Gardeniae alcohol extraction thing, the content of every active ingredient is the most different, can not during Clinical practice
Reach drug effect to maximize, cause drug effect to waste, therefore Fructus Gardeniae processing procedure is controlled, it is ensured that drug effect in Fructus Gardeniae alcohol extraction thing
Component content reaches target so that the maximized research of Fructus Gardeniae drug effect has a biggest scientific meaning, but domestic this respect
Research rare.
Summary of the invention
It is an object of the invention to provide the concocting method of a kind of Fructus Gardeniae.
It is a further object of the present invention to provide the application of the concocting method of a kind of Fructus Gardeniae.
Technical scheme is as follows:
The concocting method of a kind of Fructus Gardeniae and application thereof:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 2-3 time, after draining, it is positioned in treatment fluid, soaks 30-45 minute
After, pull out, drain, Fructus Gardeniae (parched) must be treated；
Step 3) will treat that Fructus Gardeniae (parched) is placed and in medicine roasting machine, and design temperature and rotating speed are heated to steady temperature, fry 7-10min, i.e.
Obtain Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 8-10mm gardenia powder, gardenia powder is soaked in ethanol molten
In liquid, after soak time 2-3h, filter, collect filtrate, concentrate the filtrate to relative density 1.05-1.1, be spray-dried, must carry
Take thing micropowder；
Step 5) extract micropowder can be used for preparing anti-inflammation hemostasia decoction pieces or anti-cardiovascular disease decoction pieces.
Wherein step 2) described in buff Fructus Gardeniae and treatment fluid by weight for 1:5.
Wherein step 2) described in treatment fluid be that ethanol and acetone are by volume for the mixed liquor of 15:1.
Wherein the temperature described in step 3) is 150-200 DEG C, and rotating speed is 15r/min.
Wherein the gardenia powder described in step 4) and ethanol are by weight for 1:5.
Wherein said ethanol solution be mass fraction be the ethanol solution of 78%.
The invention have the advantage that
1. what the more traditional process of preparing Chinese medicine of active drug constituents extraction amount was extracted significantly improves；
2. by controlling the temperature of medicine roasting machine and frying the medicine time, it is possible to obtain the extract that content of active component is more unified, and
Simple to operate, it is suitable for promoting.
Detailed description of the invention
Embodiment 1
The concocting method of a kind of Fructus Gardeniae and application thereof:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 2 times, after draining, it is positioned over ethanol and acetone by volume for 15:1
Mixed liquor treatment fluid in, buff Fructus Gardeniae and treatment fluid, by weight for 1:5, after soaking 30 minutes, are pulled out, are drained, must
Treat Fructus Gardeniae (parched)；
Step 3) will treat that Fructus Gardeniae (parched) is placed and in medicine roasting machine, design temperature and rotating speed, wherein temperature is 150 DEG C, rotating speed 15r/
Mim, is heated to steady temperature, fries 7min, obtains Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 8mm gardenia powder, gardenia powder is soaked in alcoholic solution
In, gardenia powder and ethanol, by weight for 1:5, after soak time 2h, filter, collect filtrate, concentrate the filtrate to relative density
1.05, it is spray-dried, obtains extract micropowder；
Step 5) extract micropowder can be used for preparing anti-inflammation hemostasia decoction pieces or anti-cardiovascular disease decoction pieces.
Embodiment 2
The concocting method of a kind of Fructus Gardeniae and application thereof:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 3 times, after draining, it is positioned over ethanol and acetone by volume for 15:1
Mixed liquor treatment fluid in, buff Fructus Gardeniae and treatment fluid, by weight for 1:5, after soaking 45 minutes, are pulled out, are drained, must
Treat Fructus Gardeniae (parched)；
Step 3) will treat that Fructus Gardeniae (parched) is placed with medicine roasting machine, and design temperature and rotating speed, wherein temperature is 200 DEG C, and rotating speed is 15r/
Min, is heated to steady temperature, fries 10min, obtains Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 10mm gardenia powder, gardenia powder is soaked in alcoholic solution
In, gardenia powder and ethanol, by weight for 1:5, after soak time 3h, filter, collect filtrate, concentrate the filtrate to relative density
1.1, it is spray-dried, obtains extract micropowder；
Step 5) extract micropowder can be used for preparing anti-inflammation hemostasia decoction pieces or anti-cardiovascular disease decoction pieces.
Embodiment 3
The concocting method of a kind of Fructus Gardeniae and application thereof:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 2 times, after draining, it is positioned over ethanol and acetone by volume for 15:1
Mixed liquor treatment fluid in, buff Fructus Gardeniae and treatment fluid, by weight for 1:5, after soaking 35 minutes, are pulled out, are drained, must
Treat Fructus Gardeniae (parched)；
Step 3) will treat that Fructus Gardeniae (parched) is placed with medicine roasting machine, and design temperature and rotating speed, temperature is 160 DEG C, and rotating speed is that 15r/min adds
Heat, to steady temperature, is fried 8min, is obtained Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 9mm gardenia powder, gardenia powder is soaked in alcoholic solution
In, gardenia powder and ethanol, by weight for 1:5, after soak time 2.5h, filter, collect filtrate, concentrate the filtrate to the closeest
Degree 1.08, is spray-dried, obtains extract micropowder；
Step 5) extract micropowder can be used for preparing anti-inflammation hemostasia decoction pieces or anti-cardiovascular disease decoction pieces.
Embodiment 4
A kind of concocting method of Fructus Gardeniae:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 3 times, after draining, it is positioned over ethanol and acetone by volume for 15:1
Mixed liquor treatment fluid in, buff Fructus Gardeniae and treatment fluid, by weight for 1:5, after soaking 35 minutes, are pulled out, are drained, must
Treat Fructus Gardeniae (parched)；
Step 3) will treat that Fructus Gardeniae (parched) is placed with medicine roasting machine, and design temperature and rotating speed, temperature is 140 DEG C, and rotating speed is that 15r/min adds
Heat, to steady temperature, is fried 8min, is obtained Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 9mm gardenia powder, gardenia powder is soaked in alcoholic solution
In, gardenia powder and ethanol, by weight for 1:5, after soak time 2h, filter, collect filtrate, concentrate the filtrate to relative density
1.09, it is spray-dried, obtains extract micropowder.
Embodiment 5
A kind of concocting method of Fructus Gardeniae:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 3 times, after draining, it is positioned over ethanol and acetone by volume for 15:1
Mixed liquor treatment fluid in, buff Fructus Gardeniae and treatment fluid, by weight for 1:5, after soaking 45 minutes, are pulled out, are drained, must
Treat Fructus Gardeniae (parched)；
Step 3) will treat that Fructus Gardeniae (parched) is placed with medicine roasting machine, and design temperature and rotating speed, wherein temperature is 210 DEG C, and rotating speed is 15r/
Min, is heated to steady temperature, fries 10min, obtains Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 10mm gardenia powder, gardenia powder is soaked in alcoholic solution
In, gardenia powder and ethanol, by weight for 1:5, after soak time 3h, filter, collect filtrate, concentrate the filtrate to relative density
1.1, it is spray-dried, obtains extract micropowder.
Embodiment 6
Measure the extract obtained middle content of drug effect components of embodiment 1-5 to add up such as following table:
| Fructus Gardeniae is sweet | α-crocetin | Tannin | Ursolic acid | |
| Fructus Gardeniae | 3.6% | 2.3% | 4.5% | 4.9% |
| Tradition is concocted | 2.77% | 1.91% | 13.6% | 3.2% |
| Embodiment 1 | 3.36% | 2.53% | 17.8% | 3.7% |
| Embodiment 2 | 3.42% | 2.99% | 21.51% | 4.28% |
| Embodiment 3 | 3.34% | 2.7% | 18.46% | 3.5% |
| Embodiment 4 | 2.19% | 1.74% | 13.2% | 1.85% |
| Embodiment 5 | 1.94% | 2.87% | 15.21% | 1.93% |
It can be seen that the more traditional process of preparing Chinese medicine of concocting method content of drug effect components that the present invention provides has carried from upper table is added up
Height, embodiment 4, embodiment 5 concoct that temperature is too low or the too high content all affecting effective ingredient.
Claims (6)
1. the concocting method of a Fructus Gardeniae and application thereof, it is characterised in that:
The concocting method of a kind of Fructus Gardeniae and application thereof:
Step 1) takes the ripe cape jasmine fruit after the Frost's Descent, picks decontamination and remaining fruit stem, is laid on straw mat, shines to peel Cheng Shen
Yellow Fructus Gardeniae；
Step 2) by above-mentioned buff Fructus Gardeniae clean water 2-3 time, after draining, it is positioned in treatment fluid, soaks 30-45 minute
After, pull out, drain, Fructus Gardeniae (parched) must be treated；
Step 3) will treat that Fructus Gardeniae (parched) is placed and in medicine roasting machine, and design temperature and rotating speed are heated to steady temperature, fry 7-10min, i.e.
Obtain Fructus Gardeniae to be extracted；
Fructus Gardeniae to be extracted is pulverized by step 4), be screened to particle diameter be after 8-10mm gardenia powder, gardenia powder is soaked in ethanol molten
In liquid, after soak time 2-3h, filter, collect filtrate, concentrate the filtrate to relative density 1.05-1.1, be spray-dried, must carry
Take thing micropowder；
Step 5) extract micropowder can be used for preparing anti-inflammation hemostasia decoction pieces or anti-cardiovascular disease decoction pieces.
The concocting method of a kind of Fructus Gardeniae the most according to claim 1 and application thereof, it is characterised in that: step 2) described in deep
Yellow Fructus Gardeniae and treatment fluid are by weight for 1:5.
The concocting method of a kind of Fructus Gardeniae the most according to claim 1 and 2 and application thereof, it is characterised in that: described process
The mixed liquor that liquid is ethanol and acetone is 15:1 by volume.
The concocting method of a kind of Fructus Gardeniae the most according to claim 1 and application thereof, it is characterised in that: described in step 3)
Temperature is 150-200 DEG C, and rotating speed is 15r/min.
The concocting method of a kind of Fructus Gardeniae the most according to claim 1 and application thereof, it is characterised in that: described in step 4)
Gardenia powder and ethanol are by weight for 1:5.
6. according to concocting method and the application thereof of a kind of Fructus Gardeniae described in claim 1 or 3, it is characterised in that: described ethanol
Solution be mass fraction be the ethanol solution of 78%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610215371.0A CN105796699A (en) | 2016-04-08 | 2016-04-08 | Processing method and application of cape jasmine fruits |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610215371.0A CN105796699A (en) | 2016-04-08 | 2016-04-08 | Processing method and application of cape jasmine fruits |
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| Publication Number | Publication Date |
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| CN105796699A true CN105796699A (en) | 2016-07-27 |
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| CN201610215371.0A Pending CN105796699A (en) | 2016-04-08 | 2016-04-08 | Processing method and application of cape jasmine fruits |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546507A (en) * | 2003-12-01 | 2004-11-17 | 李文军 | Cape jasmine extract , its preparing process and application |
| CN101343297A (en) * | 2008-07-08 | 2009-01-14 | 陕西科技大学 | Method for extracting and purifying gardenoside with absorbent charcoal |
| CN103735633A (en) * | 2013-12-30 | 2014-04-23 | 南京博士牛生物科技有限公司 | Preparation method of instant gardenia powder |
| CN104027431A (en) * | 2014-06-25 | 2014-09-10 | 宁德市农业科学研究所 | Method for processing fructus gardeniae |
| CN104931428A (en) * | 2015-05-26 | 2015-09-23 | 南京中医药大学 | On-line control method for preparation process of fructus gardenia |
-
2016
- 2016-04-08 CN CN201610215371.0A patent/CN105796699A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546507A (en) * | 2003-12-01 | 2004-11-17 | 李文军 | Cape jasmine extract , its preparing process and application |
| CN101343297A (en) * | 2008-07-08 | 2009-01-14 | 陕西科技大学 | Method for extracting and purifying gardenoside with absorbent charcoal |
| CN103735633A (en) * | 2013-12-30 | 2014-04-23 | 南京博士牛生物科技有限公司 | Preparation method of instant gardenia powder |
| CN104027431A (en) * | 2014-06-25 | 2014-09-10 | 宁德市农业科学研究所 | Method for processing fructus gardeniae |
| CN104931428A (en) * | 2015-05-26 | 2015-09-23 | 南京中医药大学 | On-line control method for preparation process of fructus gardenia |
Non-Patent Citations (1)
| Title |
|---|
| 黄继全: "栀子的炮制工艺探讨", 《江西中医药》 * |
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Application publication date: 20160727 |
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