CN105795468A - Composition having efficacy of losing weight - Google Patents
Composition having efficacy of losing weight Download PDFInfo
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- CN105795468A CN105795468A CN201610147875.3A CN201610147875A CN105795468A CN 105795468 A CN105795468 A CN 105795468A CN 201610147875 A CN201610147875 A CN 201610147875A CN 105795468 A CN105795468 A CN 105795468A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a composition having an efficacy of losing weight. The composition consists of phaseolus vulgaris fruit extract, soluble dietary fibers, green tea extract, cactus powder and L-carnitine. The composition consists of the following raw materials in parts by weight: 1-50 parts of phaseolus vulgaris fruit extract, 10-90 parts of water-soluble dietary fibers, 1-10 parts of green tea extract, 1-20 parts of cactus powder and 1-10 parts of L-carnitine. The components of the composition have synergistic effects, so that the composition can effectively block starch degradation, inhibit starch absorption, inhibit fat synthesis, promote fat metabolism and conversion, fully block fat production, regulate intestinal flora, reach the effects of losing weight, shaping body, and controlling weight in a regular consumption, and at the same time is also suitable for patients with diabetes to take.
Description
Technical field
The present invention relates to a kind of efficacy, a kind of compositions with effect of weight reducing.
Background technology
In recent years, socioeconomic developing rapidly, material is more and more abundanter, daily life level
Being improved, living and diet structure is also along with there occurs change.Simultaneously as the public is to health knowledge
Shortage, overweight and fat be increasingly becoming affect the healthy important public hygiene problem of people's life it
One.Within 2006, in the 10th world's obesity conference that Sydney, AUS is held, participant expert send sternly
Strict warning: obesity is a social problem, constitutes a threat to female mental；Obesity is that a medical science is asked equally
Topic, may will shorten the life-span of following several generations；And it or a whole world have to faced by serious
Economic problems.It is the chronic disease of maximum that whole world adult faces that World Health Organization (WHO) (WHO) explicitly points out obesity
Disease, regards fat as one of big medical science social problem of the world four.
At present in developed country, overweight and obese people occupies the biggest ratio, and cause because of fat is strong
Kang Wenti the most increasingly causes the concern of people.According to the statistics of 1998, there are about the crowd of 25% in the U.S.
Being in fat state, in annual dead crowd, about 280000～325000 cause due to obesity,
Causing can being positioned at second, be only second to smoking in Precaution factors of death；And it is strong according to U.S.'s third time
Health nutrition education generaI investigation data show, in the adult of more than 20 years old, there are about 50.4% be in overweight with
Fat state.The situation of Britain also allows of no optimist, it is estimated that, to the year two thousand twenty, men and women's obese people will divide
Do not account for the 34% and 38% of total population.The problem of obesity of old people also merits attention, U.S.'s tune of 2000
Look into display, 65-74 year elderly population in, the male of 33% and the women of 39% are in fat state.
Since reform and opening-up, China's income of residents has had bigger growth, meanwhile, the traditional food of China
Culture and the social mode of Chinese style, the rapid growth for obese people is laid a good foundation.According to 2005
Portion show for the investigation of 209849 example samples, China resident is overweight and the ratio of obese people respectively
It is 17.6% and 5.6%, adds up to and account for the 23.2% of total investigation population；This part of investigation also shows significantly
Urban-rural Difference, Urban population is overweight and fat ratio is higher than rural population, the most metropolitan overweight and fertile
Fat rate is respectively 25.0%, 10.6%.The situation in domestic each province and city is not quite similar: within 2010, Kunming is to 5381
The investigation of example crowd shows, overweight and obese people accounts for 25.73% and 8.09% respectively, the most also shows
Women is higher than the phenomenon of male；One investigation display of Tianjin, this area is overweight and obesity rates is up to 51.2%.
From these numerically it can be seen that the ratio of the overweight/obesity crowd of China mutually with developed country
Under.And along with the adjustment of Industry Structure and the support of national policy, traditional backward areas, as
The economy in west area, rural area will be developed faster, according to conventional experience, incident general
It can be the outburst of Overweight-obesity crowd.
Fat unfavorable to the health of human body.Numerous disease has been found out in relevant research, such as type Ⅱdiabetes mellitus,
Cardiovascular diseases, osteoarthritis, hypertension, immune function depression etc. are all relevant with obesity, thus cause
Metabolic syndrome becomes the second largest cause of the death after smoking.Along with body weight increases, people are not only made to suffer from
Sick probability rises, and corresponding medical expense is also increasing, and all can to the physiology of people, psychological aspects
Bring adverse influence.
Along with the increase of fat number, the concern of obese people is the most gradually heated up by society.Improve fat shape
Condition, is not only a Man's Demands, the especially main trend of society.So, diet products contain huge
The market demand, has lasting captivation to the obese people day by day pursuing healthy living.
Summary of the invention
The technical problem to be solved is to provide a kind of compositions with effect of weight reducing.
For solving above-mentioned technical problem, the technical scheme is that
A kind of compositions with effect of weight reducing, by Semen Phaseoli Vulgaris extract, water soluble dietary fiber, green tea
Extract, cactus powder and L-carnitine composition, the part of Semen Phaseoli Vulgaris extract 1-50 based on its parts by weight,
Water soluble dietary fiber 10-90 part, green tea extract 1-10 part, cactus powder 1-20 part, left-handed meat
Alkali 1-10 part.
Preferably, the above-mentioned compositions with effect of weight reducing, Semen Phaseoli Vulgaris extract based on its parts by weight
10-40 part, water soluble dietary fiber 50-80 part, green tea extract 4-9 part, cactus powder 3-10 part,
L-carnitine 2-7 part.
Preferably, the above-mentioned compositions with effect of weight reducing, Semen Phaseoli Vulgaris extract 35 based on its parts by weight
Part, water soluble dietary fiber 70 parts, green tea extract 8 parts, cactus powder 5 parts, L-carnitine 5 parts.
Preferably, the above-mentioned compositions with effect of weight reducing, described Semen Phaseoli Vulgaris extract passes through extraction process by water
Prepare.
Preferably, the above-mentioned compositions with effect of weight reducing, described water soluble dietary fiber be resistant dextrin,
Inulin, the one of polydextrose or combination in any.
Preferably, the above-mentioned compositions with effect of weight reducing, described green tea extract passes through extraction process by water system
?.
Preferably, the above-mentioned compositions with effect of weight reducing, described cactus powder by Radix et Caulis Opuntiae Dillenii and/or
Radix et Caulis Opuntiae Dillenii fruit carries out extraction process by water and prepares.
The preparation method of the above-mentioned compositions with effect of weight reducing, specifically comprises the following steps that
By Semen Phaseoli Vulgaris extract, water soluble dietary fiber, green tea extract, cactus powder, L-carnitine
Cross 80-100 mesh sieve, mixer mixes 30-60 minute, after having mixed, carries out fill.
The usage and dosage of the above-mentioned compositions with effect of weight reducing: 20g/ days, take at twice.
The invention has the beneficial effects as follows:
The above-mentioned compositions with effect of weight reducing, each component synergism, effectively block amylolysis, press down
Starch processed absorbs, and suppression lipogenesis, promotion lipid metabolism and conversion, comprehensive obstruction fat produce,
Regulating intestinal canal flora, often eats, and can reach to lose weight, mould build, the effect of control body weight,
Meanwhile, said composition also is adapted for diabetes patient and takes.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
A kind of compositions with effect of weight reducing, by Semen Phaseoli Vulgaris extract, water soluble dietary fiber, green tea
Extract, cactus powder and L-carnitine composition, (Semen Phaseoli Vulgaris extract, aqueous soluble dietary are fine for each component
Dimension, green tea extract, cactus powder and L-carnitine) it is commercial goods, Semen Phaseoli Vulgaris extract passes through
Extraction process by water obtains, and green tea extract is obtained by extraction process by water, and cactus powder is obtained by extraction process by water,
Described water soluble dietary fiber is that resistant dextrin, inulin and polydextrose are by weight 1:1:1 mixing group
Close.Concrete consumption is shown in Table 1.
Table 1
The preparation method of the described compositions with effect of weight reducing, specifically comprises the following steps that
By Semen Phaseoli Vulgaris extract, water soluble dietary fiber, green tea extract, cactus powder, L-carnitine
Cross 80 mesh sieves, mixer mixes 45 minutes, after having mixed, carries out fill.
The above-mentioned compositions with effect of weight reducing, in each component:
Semen Phaseoli Vulgaris extract has warming the middle warmer and descending qi, profit the intestines and stomach, the only function such as singultus, kidney tonifying complement, is one
Plant nourishing dietetic therapy good merchantable brand.Semen Phaseoli Vulgaris extract is rich in alpha-amylase inhibitor and dietary fiber.Alphalise starch
Enzyme inhibitor is a kind of pure-natural biological active substance, belongs to the one of glycosylhydrolase inhibitor, and it passes through
Effectively block or delay high starch food (rice, wheaten food, miscellaneous grain crops and relevant snacks and cake) forms sediment
The hydrolysis of powder and digestion, reduce the decomposition of starchy carbohydrate material in food and absorb, for obese patient, and can
Minimizing sugar, to adipose conversion, delays intestinal to empty, and increase fat consumption is to alleviate weight, thus plays
Fat-reducing effect.
Green tea extract main component tea polyphenols, is Catechin in Tea class, flavonoid, phenolic acids and flower
The general name of pigment compound, its mechanism of action may have three below aspect: 1. strengthens muscular tissue fat
The oxidative metabolism rate of fat acid；2. the synthesis of body fat tissue is reduced；3. intestinal satisfied fatty acid is suppressed
Absorb.Have aid digestion and drop low-fat important effect.
Water soluble dietary fiber is relatively more effective for reducing cholesterol, in the metabolism in the way of fermentation of big enteral,
The energy provided is less than common carbohydrate；In food, form full-bodied colloidal sol and gel, easily produce
Raw satiety；With the material such as protein, fat formed complex, reduce human body to starch, protein and
The absorption of fat；Promote the fat consumption of internal storage.During loss of weight, assist sending out of overall efficacy
Wave.
Among the people in China, Radix et Caulis Opuntiae Dillenii and Radix et Caulis Opuntiae Dillenii fruit be used for curing mainly heart peratodynia disease, cough, have sore throat,
Acute mastitis, furuncle, parotitis etc., also can make nourishing and fit keeping function health care and be used.The triterpene soap contained in cactus powder
Glycoside can regulate human secretory function and the activity of regulation lipase, promotes that superabundant fats decomposes, and energy
Effectively stop fat in intestinal absorption.One random, comparison, in double-blind trial, 49 regulars
The women of weight (between 20 and 25) participates in test, and result shows that the group on time taking Radix et Caulis Opuntiae Dillenii fruit powder does not has
There is notable fat mass to change, and placebo group has substantially weightening finish (at most 3 kilograms increases).Cactus powder
Can reach diuresis and control body weight effect, Radix et Caulis Opuntiae Dillenii fruit powder not on blood and the impact of mineral,
For good dietary supplement or functional food or Weight management beverage.
L-carnitine can improve the aerobatic exercise rush fat metabolism to fat and super severe one, effectively
Increase the fall heavily fat reducing effect of aerobatic exercise.
Above-mentioned each component influences each other, synergism, for blocking the source that fat produces, adipose conversion
Process is designed, and does not affect normal diet, formula collocation rationally, can at normal diet, disappear
While hunger sensation, effectively block the decomposition of starch in high starch food, block 80% calorie intake,
Do not affect the absorption of other nutritional labeling, and do not enter blood circulation, do not act on cerebral nerve
Maincenter, fat-reducing the most not appetite-suppressing, do not have diarrhoea, weak, anorexia phenomenon, body weight does not rebounds,
Glucose absorption can also be reduced simultaneously, thus reduce insulin secretion, reduce lipogenesis, be suitable for sugar
Urine sick obese patient take；Can reduce abdominal part and subcutaneous fat, blood fat, blood glucose and the gallbladder in blood is solid
Alcohol, helps fat-reducing, forms precipitation with cholesterol, thus also inhibits the absorption of intestinal inner cholesterol, promotees
Enter the beta-oxidation of fatty acid, thus promote that lipid metabolism is changed into energy；Effectively reduce cholesterol, produce
Keep digestive system healthy while satiety, reduce the harmful intestinal tract bacteria causeed fat.
Efficacy experiments:
1 material and instrument
1.1 laboratory animals and feedstuff
SPF level SD rat 72, male, weight about 100 ± 10g, by Beijing, dimension tonneau China is real
Test zoo technical company limited to provide, feeding environment temperature 18-22 DEG C, natural lighting, freely ingest and drink
Water.
High lipid food: 80% normal feedstuff, 10% yolk powder and 10% Adeps Sus domestica.
1.2 laboratory animal environment:
SPF level barrier environment, the quality certification number: SYXK (Tianjin) 2012-0004.
1.3 medicines and reagent
There is the compositions of effect of weight reducing: be configured to concentration with distilled water during use and divide described in embodiment 1-9
Do not set basic, normal, high dosage group with 5 times, 10 times and 30 times of human body recommended dose (20g/ days).
Orlistat (or listat, orlistat): Basel, SUI Hao Fumai Roche company limited produces；
It is configured to the gavage liquid that concentration is 10mg/mL, by 60mg kg with distilled water-1·d-1Gastric infusion.
1.4 main apparatus and consumables associated therewiths
Gastric perfusion needle, syringe, balance, refrigerated centrifuger, dissecting instrument, spectrophotometer (Siemens
Dimension RxL Max full automatic biochemical apparatus), cholesterol, sodium cholate, serum total cholesterol (TC),
Triglyceride (TG), HDL-C (HDL) measure test kit.
2 experimental techniques
By rat adaptability feed 7d under experimental situation, it is randomly divided into 6 groups: blank group；Model
Matched group；Positive drug control group and Weight reducing compound are divided into basic, normal, high dosage group, and often group 12 is big
Mus.Timing every day gavage, feeding (feedstuff administered dose is respectively organized equal).Blank group gavage distilled water,
Feed normal diet (is pulled together purchased from Austria of section)；Model control group gavage distilled water, feed height fat nutrient fodder；
Positive controls is with orlistat solution gavage；Weight reducing compound basic, normal, high dosage group distilled water reconstitutes
Liquid gavage.Test 40 days.Record during experiment every treated animal to appetite, surplus appetite and berley amount, fixed
Phase weighs, it is long to survey body, and fasting 12h at the end of experiment, femoral artery takes blood, isolates serum to be measured.Solve
Cut open rat, perusal rat body fat calmness situation and internal organs situation of change.Take body fat (testis and
Perirenal fat pad) and weigh.
3 data process and result judges
Experiment SPSS16.0 carries out statistical analysis.
4 interpretations of result
The impact on obese rat body weight of 4.1 Weight reducing compounds
Before weight-reducing experiment starts, each group rat body weight there was no significant difference (P > 0.05), after testing 40 days,
Fat-reducing matched group and experiment contrast group are close to blank group body weight, and pole is substantially less than obese model group rat
Body weight.Compare with model control group, blank group, fat-reducing matched group and basic, normal, high dosage three
Rats in test groups body weight is all significantly lower than model control group (P < 0.05), and basic, normal, high dosage three
Test group and blank group and fat-reducing matched group compare and there was no significant difference (P > 0.05), the results are shown in Table 2.
The impact on obese rat body weight of table 2 Weight reducing compound
Note: compare with model control group, * is P < 0.05.
The impact on obese rat body fat weight of 4.2 Weight reducing compounds
Blank group, fat-reducing matched group and 3 rats in test groups kidneys, surrounding genital fat after 40 days
Weight all significantly lower than model control group (P < 0.05), and three test group of basic, normal, high dosage with
Blank group and fat-reducing matched group compare and there was no significant difference (P > 0.05).Between each test group and with
Blank group, fat-reducing matched group there was no significant difference (P > 0.05) more statistically.The results are shown in Table
3。
The impact on obese rat body fat weight of table 3 Weight reducing compound
Note: compare with model control group, * is P < 0.05.
The impact on obese rat Lee ' s index of 4.3 Weight reducing compounds
Lee's index is similar with Body Mass Index BMI of people, main reflection body obese degree.
After 40 days, Lee ' the s index of blank group, fat-reducing matched group and rats in test groups is all significantly lower than
Model control group (P < 0.05), and between three test group of basic, normal, high dosage and test group is with empty
Difference there are no significant meaning (P > 0.05) between white matched group and fat-reducing matched group.The results are shown in Table 4.
The impact on obese rat Lee ' s index of table 4 Weight reducing compound
Note: compare with model control group, * is P < 0.05.
The impact on obese rat fat coefficient of 4.4 Weight reducing compounds
Fat coefficient=body fat weight/body weight × 100%
Fat coefficient is the percentage ratio of kidney and surrounding genital fat pad and rat body weight in rat body, also
Reflect rat body fat number with the obese degree of rat.
After 40 days, the fat coefficient of blank group, fat-reducing matched group and rats in test groups is all significantly lower than mould
Type matched group (P < 0.05), and between three test group of basic, normal, high dosage and test group is with blank
Difference there are no significant meaning (P > 0.05) between matched group and fat-reducing matched group, the results are shown in Table 5.
The impact on obese rat fat coefficient of table 5 Weight reducing compound
Conclusion:
Obesity is most commonly that this experiment is built due to the Simple Obesity that Energy intaking is too much caused at present
Vertical obese rat model, similar to mankind's Feeding regularity, there is important reality meaning for fat research
Justice.
Orlistat is the conventional slimming medicine that U.S. food Drug Administration (FDA) ratifies up to now
One of.This experiment selects orlistat as fat-reducing positive control drug, facilitates look at subtracting of Weight reducing compound
Fertilizer efficiency fruit.
This experimentation shows, compositions of the present invention is to experimental rat body weight, the reduction effect of body fat
Substantially, there is notable effect of weight reducing.In three dosage, the action effect of high dose group is best.
Above-mentioned retouch in detail what the compositions with effect of weight reducing of the present invention was carried out with reference to embodiment
State, be illustrative rather than determinate, can according to restriction scope list several embodiments,
Therefore changing and modifications under without departing from present general inventive concept, within should belonging to protection scope of the present invention.
Claims (7)
1. a compositions with effect of weight reducing, it is characterised in that: by Semen Phaseoli Vulgaris extract, water solublity
Dietary fiber, green tea extract, cactus powder and L-carnitine composition, Semen Phaseoli Vulgaris based on its parts by weight
Extract 1-50 part, water soluble dietary fiber 10-90 part, green tea extract 1-10 part, cactus powder
1-20 part, L-carnitine 1-10 part.
The compositions with effect of weight reducing the most according to claim 1, it is characterised in that: heavy by it
Amount number meter Semen Phaseoli Vulgaris extract 10-40 part, water soluble dietary fiber 50-80 part, green tea extract 4-9
Part, cactus powder 3-10 part, L-carnitine 2-7 part.
The compositions with effect of weight reducing the most according to claim 2, it is characterised in that: heavy by it
Amount number meter Semen Phaseoli Vulgaris extract 35 parts, water soluble dietary fiber 70 parts, green tea extract 8 parts, celestial being
People slaps 5 parts of powder, L-carnitine 5 parts.
4. according to the compositions with effect of weight reducing one of claim 1-3 Suo Shu, it is characterised in that:
Described Semen Phaseoli Vulgaris extract is prepared by extraction process by water.
5. according to the compositions with effect of weight reducing one of claim 1-3 Suo Shu, it is characterised in that:
Described water soluble dietary fiber is resistant dextrin, inulin, the one of polydextrose or combination in any.
6. according to the compositions with effect of weight reducing one of claim 1-3 Suo Shu, it is characterised in that:
Described green tea extract is prepared by extraction process by water.
7. according to the compositions with effect of weight reducing one of claim 1-3 Suo Shu, it is characterised in that:
Described cactus powder is prepared by extraction process by water.
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