CN105785286B - A kind of fetus heart Magnetic testi probe, system and method - Google Patents

A kind of fetus heart Magnetic testi probe, system and method Download PDF

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CN105785286B
CN105785286B CN201610231298.6A CN201610231298A CN105785286B CN 105785286 B CN105785286 B CN 105785286B CN 201610231298 A CN201610231298 A CN 201610231298A CN 105785286 B CN105785286 B CN 105785286B
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magnetic field
magnetic
environmental
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axis magnetometer
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CN105785286A (en
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王永良
徐小峰
张树林
谢晓明
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MANDI MEDICAL INSTRUMENT (SHANGHAI) Co.,Ltd.
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Shanghai Institute of Microsystem and Information Technology of CAS
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/02Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/025Compensating stray fields
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/43Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4343Pregnancy and labour monitoring, e.g. for labour onset detection
    • A61B5/4362Assessing foetal parameters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/02Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/035Measuring direction or magnitude of magnetic fields or magnetic flux using superconductive devices
    • G01R33/0354SQUIDS

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  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
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  • Pediatric Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Magnetic Variables (AREA)

Abstract

A kind of fetus heart Magnetic testi probe of present invention offer, system and method, including:First three axis magnetometer, the second three axis magnetometer, core gradiometer, the first three axis magnetometer are detected the environmental magnetic field residing for core gradiometer, and magnetic compensation coil is driven to inhibit environmental magnetic field;Second three axis magnetometer is detected the environmental magnetic field after inhibition;Tested magnetic field is detected in environmental magnetic field of the core gradiometer after inhibition, the second three axis magnetometer and core gradiometer output signal are synthesized, the environmental magnetic field signal in core gradiometer output signal is offset, obtains measured signal.The present invention can realize the signal detection of high s/n ratio under unshielded environment, system cost is greatly reduced without using screened room, improve the flexibility of system, breach traditional superconducting quantum interference device magnetic detector applies barrier, superconducting quantum interference device systematic difference is further pushed, there is important economic value.

Description

A kind of fetus heart Magnetic testi probe, system and method
Technical field
The present invention relates to Weak magentic-field field of detecting, more particularly to a kind of fetus heart Magnetic testi probe, system and method.
Background technology
Based superconductive quantum interference device (Superconducting Quantum Interference Device, below Abbreviation SQUID) magnetic detector be that the noise level that is currently known is minimum, most sensitive magnetic detector.It is widely used in biology The Weak magentic-fields detection application such as magnetic field, geomagnetic anomaly of the Earth, extremely low field nuclear magnetic resonance field, detectivity has reached winged Spy (10-15Tesla) magnitude.There is very high scientific research and application value in the detection of atomic low-intensity magnetic field, scientific research.
As shown in Figure 1, the magnetic detector of based superconductive quantum interference device SQUID is mainly made of following components:
1, search coil, i.e. superconduction pick-up winding:It is distributed according to the magnetic field space in measured signal source, coiling is used for Couple the magnetic flux that measured signal magnetic field generates.Pick-up winding uses superconducting line coiling, and it is equally superconduction to access in SQUID device The input coil of line coiling constitutes a superconducting loop.According to the flux quautization effect of superconducting loop, pick-up winding coupling Magnetic flux will make superconducting ring generate electric current Is in proportion, and the input coil of electric current inflow SQUID device generates magnetic flux and is coupled to again In SQUID magnetic flux transducers.
2, SQUID magnetic flux transducers are made of SQUID device and its mating SQUID reading circuit, by SQUID impressions Magnetic flux is converted linearly into voltage Vout in proportion.
The magnetic flux pick-up winding and SQUID magnetic flux transducers of superconduction coiling combine in this way, are achieved that catching for tested magnetic field The linear transformation of the magnetic field-voltage obtained.Form the magnetic detector with magnetic field detection ability.Since its sensitivity is very high, Therefore it is widely used in the instrument and equipment of faint magnetic signal.
An important applied field in its faint magnetic detector of superconductive quantum interference is biological magnetic field detection, builds heart magnetic The high-end Medical Devices such as figure instrument.Wherein fetus magnetocardiograph has important application potential.The detection means of Fetal heart Very limited, ultrasound can only carry out structural detection, and electro-cardiologic methods are due to parent conductivity problems, it is difficult to obtain effective electrocardio letter Number.Only mcg-signals are not influenced by parent conductivity problems, can effectively reflect fetal cardiac activity information, while completely noninvasive Detection, therefore fetus heart magnetic detection is known as the important means of heart of fetus detection.
The core of fetus mcg-signals detection instrument is its Magnetic Sensor of superconductive quantum interference, and fetus mcg-signals are very micro- It is weak, and maximum only several pT (skin tesla, 10-12Tesla), it compares and several micro- special (micro- spies:10-6Tesla) earth environment The fluctuation in magnetic field, the signal that extract high s/n ratio are extremely difficult.Therefore it is carried out on the basis of traditional SQUID magnetic detectors The special designing of probe could obtain faint fetus mcg-signals in powerful background interference magnetic field.
The magnetic field detectors of based superconductive quantum interfering device have high sensitivity, and magnetic field resolution ratio, which can reach, flies spy (10-15Tesla) magnitude.Because the measuring range of its high sensitivity, the sensor is typically small, therefore is carrying out faint magnetic letter When number detection, prodigious challenge is encountered, main cause is to be filled with earth magnetic field in environment residing for us, earth magnetic field Size is in 50 micro- special (micro- spies:10-6Tesla) left and right, while the fluctuation in earth magnetic field has hundreds of nanotesla (nanoteslas:10-9Te Si Draw) arrive several micro- spies.The signal that the interference of this background magnetic field can be differentiated relative to SQUID magnetic detectors is huge.Therefore exist When carrying out faint magnetic signal detection, this ambient noise will seriously affect the signal-to-noise ratio of detectable signal.
It solving the above problems, the technological means of use has,
1) screened room is used to inhibit environmental magnetic field.When carrying out faint magnetic signal detection using SQUID magnetic detectors at present, need It is carried out in a kind of equipment with environmental magnetic field shielding in screened room.Using screened room, occupied space is big, inconvenient to use, Cost is very expensive (200 ten thousand to 1,000 ten thousand yuan) simultaneously, seriously limits the application of SQUID sensors.
2) gradient coil is used to inhibit environmental magnetic field.Using the complicated pick-up winding winding method of single order or high-order, into Row environmental magnetic field inhibits.
It is illustrated in figure 2 planar gradiometer, Fig. 3 show axial gradiometers.Two magnetic fields are formed when gradient coil coiling Coupling area, the two sizes are equal, and normal direction is parallel, and the magnetic flux symbol of two areas coupling is on the contrary, i.e. two lines The magnetic flux of the coupling of circle subtracts each other, therefore the magnetic field being evenly distributed, while the magnetic field generation being coupled in two area coils Magnetic flux offsets, i.e., common-mode signal is offset.And Distribution of Magnetic Field is different on two areas, that is, has the magnetic field of gradient, in the ladder Magnetic flux is will convert on degree coil, accesses and carries out voltage conversion in SQUID magnetic flux transducers.Therefore gradient coil realizes gradient The detection of signal, and uniform magnetic field signal is inhibited.That is, gradient coil has the common mode inhibition capacity in magnetic field.
But since the coiling of coil is not ideal symmetrical, there are errors for two area coils, and common-mode rejection ratio is only It can accomplish 104Left and right is still not enough to powerful background magnetic field being suppressed to the level less than tested Weak magentic-field.With traditional gradient Larger environmental disturbances magnetic field signal is still introduced in the sensor output of coil, the signal-to-noise ratio of signal detection still cannot be satisfied no screen Cover the requirement that fetus mcg-signals detect under environment.
Invention content
In view of the foregoing deficiencies of prior art, the purpose of the present invention is to provide a kind of fetus heart Magnetic testis to pop one's head in, System and method, for solving the problems, such as that environmental magnetic field generates interference to tested Weak magentic-field in the prior art.
In order to achieve the above objects and other related objects, the present invention provides a kind of fetus heart Magnetic testi probe, the fetus Heart Magnetic testi probe includes at least:
First three axis magnetometer, the second three axis magnetometer and core gradiometer;
First three axis magnetometer is detected the environmental magnetic field residing for the core gradiometer, for driving magnetic to mend Coil is repaid, environmental magnetic field is inhibited;
Second three axis magnetometer is detected the environmental magnetic field after inhibition;
Tested magnetic field is detected in environmental magnetic field of the core gradiometer after inhibition, by offsetting the core Environmental magnetic field signal in gradiometer output signal, obtains measured signal.
Preferably, the core gradient is calculated as superconduction differential mode coil, is detected to the magnetic field of first direction.
It is highly preferred that second three axis magnetometer includes the magnetic field pick-up winding in three directions, respectively to first direction, The magnetic field of second direction and third direction is detected, and the first direction, the second direction and the third direction are two-by-two Vertically.
It is highly preferred that first three axis magnetometer includes the magnetic field pick-up winding in three directions, respectively to described first The magnetic field in direction, the second direction and the third direction is detected.
It is highly preferred that the environmental magnetic field that superconducting line is surrounded according to symmetry axis cabling, symmetry axis both sides in the core gradiometer Equilibrium area and measured signal induction zone area equation and symmetrical, superconducting line cross wiring after symmetry axis makes symmetry axis two For the direction of winding of side superconducting line on the contrary, the line end of superconducting line is drawn at symmetry axis, the environmental magnetic field that symmetry axis both sides surround is flat Heng Qu and the magnetic flux of measured signal induction zone coupling are cancelled out each other.
It is highly preferred that it is provided with high-permeability material in the environmental magnetic field equilibrium area and the measured signal induction zone, The relative permeability of the high-permeability material is not less than 10.
It is highly preferred that the high-permeability material in the environmental magnetic field equilibrium area and the measured signal induction zone has phase Same medium parameter.
It is highly preferred that the medium parameter includes magnetic conductivity, filling space.
In order to achieve the above objects and other related objects, the present invention also provides a kind of fetus heart magnetic detection system, the tires Youngster's heart magnetic detection system includes at least:Above-mentioned fetus heart Magnetic testi probe, SQUID sensors, coil driver, magnetic compensation line Circle and noise-cancellation circuit;Wherein,
After the output end of first three axis magnetometer connects one group of SQUID sensor, pass through one group of coil driver It is connected to one group of magnetic compensation coil, magnetic compensation coil generates magnetic signal and inhibits to environmental magnetic field;
After second three axis magnetometer connects another group of SQUID sensor with the output end of the core gradiometer, even It is connected to noise-cancellation circuit, the noise-cancellation circuit will detect in environmental magnetic field of the core gradiometer after inhibition Environmental magnetic field after the inhibition that tested magnetic field signal is detected with second three axis magnetometer is synthesized, and the core is offset Environment magnetic field signal, obtains measured signal in gradiometer output signal.
In order to achieve the above objects and other related objects, the present invention also provides a kind of fetus heart magnetic detection method, the tires Youngster's heart magnetic detection method includes at least:
The environmental magnetic field of fetus heart magnetic is detected based on a three axis magnetometer, and drives magnetic compensation coil to environment magnetic Field inhibit;Environmental magnetic field after being inhibited based on the detection of another three axis magnetometer;Pressed down based on a core gradiometer Tested magnetic field is detected in environmental magnetic field after system, obtains the tested magnetic field signal with environmental magnetic field;Environment will be carried The tested magnetic field signal in magnetic field is synthesized with the environmental magnetic field signal after inhibiting, and offsets environment in the core gradiometer output signal Magnetic field signal obtains tested fetus mcg-signals.
As described above, fetus heart Magnetic testi probe, the system and method for the present invention, have the advantages that:
Fetus heart Magnetic testi probe, the system and method for the present invention can realize the micro- of high s/n ratio under unshielded environment Infant laser signal detection greatly reduces system cost without using screened room, improves the flexibility of system, breaches traditional superconduction amount Sub- interferometer magnetic detector applies barrier, further pushes superconducting quantum interference device systematic difference, has important economy Value.
Meanwhile the present invention program is suitable for being operated in the low temperature SQUID sensors and superconducting coil of 4.2K liquid helium regions, Suitable for being operated in the high-temperature superconductor SQUID sensors and superconducting coil of the liquid nitrogen temperatures 77K.
Description of the drawings
Fig. 1 is shown as the magnetic detector schematic diagram of based superconductive quantum interference device SQUID in the prior art.
Fig. 2 is shown as planar gradiometer schematic diagram in the prior art.
Fig. 3 is shown as axial gradiometers schematic diagram in the prior art.
Fig. 4 is shown as the fetus heart Magnetic testi probe front view of the present invention.
Fig. 5 is shown as core of the invention gradiometer configuration schematic diagram.
The fetus heart Magnetic testi probe connection SQUID device and the side view after sensor circuit that Fig. 6 is shown as the present invention.
The fetus heart Magnetic testi probe connection SQUID device and the top view after sensor circuit that Fig. 7 is shown as the present invention.
Fig. 8 is shown as the fetus heart magnetic detection system schematic diagram of the present invention.
Fig. 9 is shown as the specific implementation mode schematic diagram of the fetus heart magnetic detection system of the present invention.
Component label instructions
1 fetus heart Magnetic testi is popped one's head in
21~23 SQUID sensors
3 driving circuits
4 noise-cancellation circuits
Specific implementation mode
Illustrate that embodiments of the present invention, those skilled in the art can be by this specification below by way of specific specific example Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through in addition different specific realities The mode of applying is embodied or practiced, the various details in this specification can also be based on different viewpoints with application, without departing from Various modifications or alterations are carried out under the spirit of the present invention.
Please refer to Fig. 4~Fig. 9.It should be noted that the diagram provided in the present embodiment only illustrates this in a schematic way The basic conception of invention, package count when only display is with related component in the present invention rather than according to actual implementation in schema then Mesh, shape and size are drawn, when actual implementation kenel, quantity and the ratio of each component can be a kind of random change, and its Assembly layout kenel may also be increasingly complex.
As shown in Figure 4 to 7, the present invention provides a kind of fetus heart Magnetic testi probe 1, the fetus heart Magnetic testi probe 1 It includes at least:
First three axis magnetometer, the second three axis magnetometer and core gradiometer;
First three axis magnetometer is detected the environmental magnetic field residing for the core gradiometer, for driving magnetic to mend Coil is repaid, environmental magnetic field is inhibited;
Second three axis magnetometer is detected the environmental magnetic field after inhibition;
Tested magnetic field is detected in environmental magnetic field of the core gradiometer after inhibition, by offsetting the core Environmental magnetic field signal in gradiometer output signal, obtains measured signal.
Specifically, first three axis magnetometer includes the magnetic field pick-up winding in three directions, respectively to first direction, Two directions and the magnetic field of third direction are detected.As shown in figure 4, in the present embodiment, being defined as carrying out the magnetic field of X-direction The pick-up winding X1 of detection, the normal direction of magnetic flux coupling area are parallel with X-axis;It is picked up to what the magnetic field of Y-direction was detected Line taking circle Y1, the normal direction of magnetic flux coupling area are parallel with Y-axis;And to pickup leads that the magnetic field of Z-direction is detected Z1 is enclosed, the normal direction of magnetic flux coupling area is parallel with Z axis.Wherein, X-direction, Y-direction and Z-direction are vertical two-by-two, constitute one Three dimensions.
Specifically, second three axis magnetometer includes the magnetic field pick-up winding in three directions, respectively to first direction, Two directions and the magnetic field of third direction are detected.As shown in figure 4, in the present embodiment, being defined as carrying out the magnetic field of X-direction The pick-up winding X2 of detection, the normal direction of magnetic flux coupling area are parallel with X-axis;It is picked up to what the magnetic field of Y-direction was detected Line taking circle Y2, the normal direction of magnetic flux coupling area are parallel with Y-axis;And to pickup leads that the magnetic field of Z-direction is detected Z2 is enclosed, the normal direction of magnetic flux coupling area is parallel with Z axis.
Specifically, the core gradiometer G1 is superconduction differential mode coil, is detected to the magnetic field of first direction.Such as Fig. 4 It is shown, in the present embodiment, it is defined as being detected the magnetic field of X-direction.As shown in figure 5, the superconduction differential mode coil is flat Planar coil, i.e., the described superconduction differential mode coil in one plane connect up, and superconducting line is according to symmetry axis cabling, in the present embodiment, institute State the vertical line that symmetry axis is environmental magnetic field equilibrium area and the measured signal induction zone line of centres, the environment magnetic that symmetry axis both sides surround Equilibrium area and measured signal induction zone area equation and symmetrical.In the present embodiment, the environmental magnetic field equilibrium area and The shape of measured signal induction zone is circle, other are variously-shaped to be suitable for the invention superconduction differential mode coil, not with this reality Example is applied to be limited.Superconducting line cross wiring after symmetry axis makes the direction of winding of symmetry axis both sides superconducting line on the contrary, symmetry axis two The normal direction of environmental magnetic field equilibrium area and measured signal induction zone that side surrounds is parallel with X-axis, that is, is keeping environmental magnetic field flat In the case that the enclosed figure of the coil of Heng Qu and measured signal induction zone is full symmetric, circuit around to being opposite, use electric current Illustrate to be exactly, when coil midstream overcurrent, Distribution of Magnetic Field is symmetrical caused by the symmetrical region of the symmetry axis both sides, Equal in magnitude but direction on the contrary, it is so-called be symmetrically coil winding formed coupling area it is equal in magnitude, it is symmetrical.Circuit Coiling with electromagnetic induction phenomenon on the contrary, analyzed, i.e., under equally distributed magnetic field, the coupling of gradiometer symmetry axis both sides coil Magnetic flux is equal.The induced current that two coil couples magnetic flux generate is cancelled out each other in coil.Since electric current is cancelled out each other, because Under uniform magnetic field, which not will produce induced current for this.Under magnetic field only unevenly distributed, that is, there is gradient Magnetic field under, the magnetic flux of symmetry axis both sides coil coupling is different, therefore the induced current generated is different, and two coils are inducted The electric current that current subtraction generates just reflects the signal of magnetic field gradient.
The line end of superconducting line is drawn at symmetry axis, the magnetic flux phase of environmental magnetic field equilibrium area and the coupling of measured signal induction zone It mutually offsets, forms gradient output.
More specifically, it is provided with high-permeability material in the environmental magnetic field equilibrium area and the measured signal induction zone, Magnetic conductivity (magnetic permeability) is the physical quantity for characterizing magnetic medium magnetism, is indicated in space or in magnetic core space In coil flow through electric current after, generate the resistance of magnetic flux or be the ability that the magnetic line of force is connected in it in magnetic field.The public affairs of magnetic conductivity Formula is μ=B/H, and wherein H is magnetic field intensity, B is magnetic induction intensity, and conventional sign μ is indicated, μ is the magnetic conductivity of medium, or absolutely To magnetic conductivity.Described magnetic conductivity refers to relativepermeabilityμr in the present invention, be defined as magnetic permeability μ and space permeability μ 0 it Than i.e. μ r=μ/μ 0.In general:The relative permeability of air or non-magnetic material is 1, the paramagnetic material such as ferromagnetism Magnetic conductivity>1, the present invention in high-permeability material refer to relativepermeabilityμr be not less than 10 permeability magnetic material, in the present embodiment In, using the bar magnet of high-permeability material as filler.Common high-permeability material is ferrimagnet, such as soft iron, iron Oxysome etc., wherein cast iron is 200~400;Silicon steel sheet is 7000~10000;Nickel-zinc ferrite is 10~1000.Due to soft iron Equal metal materials are conductive, easily cause vortex, not as preferred material, therefore, in the present embodiment, using ferrite as The first choice of high-permeability material, it is common such as nickel-zinc-ferrite material or MnZn ferrite material.The environmental magnetic field equilibrium area With the high-permeability material medium parameter having the same of measured signal induction zone setting.The medium parameter includes magnetic conductance Rate, filling space.
In the present embodiment, first three axis magnetometer and second three axis magnetometer are relative to the core gradient Meter G1 is oppositely arranged, length of the pick-up winding X1 and X2 being detected to the magnetic field of X-direction relative to the core gradiometer G1 It is symmetrical to spend direction;The pick-up winding Y1 and Y2 being detected to the magnetic field of Y-direction is relative to the core gradiometer G1's Length direction is symmetrical;The pick-up winding Z1 and Z2 being detected to the magnetic field of Z-direction is relative to the core gradiometer G1 Symmetry axis it is symmetrical.
It is illustrated in figure 6 the side after fetus heart Magnetic testi probe 1 of the invention is connect with SQUID device, sensor circuit View;It is illustrated in figure 7 the top view after fetus heart Magnetic testi probe 1 of the invention is connect with SQUID device, sensor circuit Figure.
As shown in Fig. 8~Fig. 9, the present invention also provides a kind of fetus heart magnetic detection system, the fetus heart magnetic detection system It includes at least:
Above-mentioned fetus heart Magnetic testi probe 1, SQUID sensors, driving circuit and noise-cancellation circuit;Wherein,
After the output end of first three axis magnetometer connects one group of SQUID sensor, magnetic letter is generated by driving circuit 3 Number environmental magnetic field is inhibited.
Specifically, as shown in Fig. 8~Fig. 9, first three axis magnetometer includes pick-up winding X1, Y1 and Z1, is connected respectively The first SQUID sensors 21 are connect, the first SQUID sensors 21 include SQUID device and SQUID reading circuits.Described The output end of one SQUID sensors 21 connects driving circuit 3, and the driving circuit 3 includes coil driver and magnetic compensation Coil.First three axis magnetometer detects X, Y, the environmental magnetic field of Z-direction and generates three directions by magnetic compensation coil Offset magnetic field BCX、BCYAnd BCZ, to environmental magnetic field BEX、BEYAnd BEZInhibited.
After second three axis magnetometer connects another group of SQUID sensor with the output end of the core gradiometer, even It is connected to noise-cancellation circuit, the noise-cancellation circuit will detect in environmental magnetic field of the core gradiometer after inhibition Environmental magnetic field after the inhibition that tested magnetic field signal is detected with second three axis magnetometer is synthesized, and the core is offset Environment magnetic field signal, obtains measured signal in gradiometer output signal.
Specifically, as shown in Fig. 8~Fig. 9, second three axis magnetometer includes pick-up winding X2, Y2 and Z2, is connected respectively The 2nd SQUID sensors 22 are connect, the 2nd SQUID sensors 22 include SQUID device and SQUID reading circuits.Described The output end of two SQUID sensors 22 connects noise-cancellation circuit 4, and in the present embodiment, the noise-cancellation circuit 4 is signal Synthesizer.Second three axis magnetometer detect be suppressed after X, Y, Z-direction environmental magnetic field and be output to signal synthesis Device.As shown in Fig. 8~Fig. 9, the 3rd SQUID sensors 23 of core gradiometer G1 connections, the 3rd SQUID sensors 23 Including SQUID device and SQUID reading circuits.The output end of the 3rd SQUID sensors 23 connects noise-cancellation circuit 4, In the present embodiment, the noise-cancellation circuit 4 is signal synthesizer.Environmental magnetic fields of the core gradiometer G1 after inhibition In tested magnetic field be detected and be output to signal synthesizer.The signal synthesizer is inhibiting the core gradiometer G1 Environment magnetic after the inhibition that the tested magnetic field signal detected in environmental magnetic field afterwards is detected with second three axis magnetometer Field is synthesized, and is offset environment magnetic field signal in the core gradiometer G1 output signals, is obtained clean measured signal, noise Than greatly improving.
The present invention also provides a kind of fetus heart magnetic detection methods, based on a three axis magnetometer to the environmental magnetic field of fetus heart magnetic It is detected, and magnetic compensation coil is driven to inhibit environmental magnetic field;It is inhibited based on the detection of another three axis magnetometer Environmental magnetic field afterwards;Tested magnetic field is detected in environmental magnetic field based on a core gradiometer after inhibition, is carried The tested magnetic field signal of environmental magnetic field;Tested magnetic field signal with environmental magnetic field is closed with the environmental magnetic field signal after inhibiting At offsetting environment magnetic field signal in the core gradiometer output signal and obtain tested fetus mcg-signals.
As described above, fetus heart Magnetic testi probe, the system and method for the present invention, have the advantages that:
Fetus heart Magnetic testi probe, the system and method for the present invention can realize the micro- of high s/n ratio under unshielded environment Infant laser signal detection greatly reduces system cost without using screened room, improves the flexibility of system, breaches traditional superconduction amount Sub- interferometer magnetic detector applies barrier, further pushes superconducting quantum interference device systematic difference, has important economy Value.
Meanwhile the present invention program is suitable for being operated in the low temperature SQUID sensors and superconducting coil of 4.2K liquid helium regions, Suitable for being operated in the high-temperature superconductor SQUID sensors and superconducting coil of the liquid nitrogen temperatures 77K.
In conclusion the present invention provides a kind of fetus heart Magnetic testi probe, including:First three axis magnetometer, the two or three axis Magnetometer and core gradiometer;First three axis magnetometer examines the environmental magnetic field residing for the core gradiometer It surveys, for driving magnetic compensation coil, environmental magnetic field is inhibited;Second three axis magnetometer is to the environmental magnetic field after inhibition It is detected;Tested magnetic field is detected in environmental magnetic field of the core gradiometer after inhibition, by offsetting the core Environmental magnetic field signal in heart gradiometer output signal, obtains measured signal.A kind of fetus heart magnetic detection system is also provided, including Fetus heart Magnetic testi probe, SQUID sensors, coil driver, magnetic compensation coil and noise-cancellation circuit;Wherein, institute After the output end one group of SQUID sensor of connection for stating the first three axis magnetometer, one group is connected to by one group of coil driver Magnetic compensation coil, magnetic compensation coil generate magnetic signal and inhibit to environmental magnetic field;Second three axis magnetometer and the core After the output end of heart gradiometer connects another group of SQUID sensor, it is connected to noise-cancellation circuit, the noise-cancellation circuit will The tested magnetic field signal that the core gradiometer detects in the environmental magnetic field after inhibition is examined with second three axis magnetometer Environmental magnetic field after the inhibition measured is synthesized, and is offset environment magnetic field signal in the core gradiometer output signal, is obtained Measured signal.And a kind of fetus heart magnetic detection method, include based on a three axis magnetometer to the environmental magnetic field of fetus heart magnetic into Row detection, and magnetic compensation coil is driven to inhibit environmental magnetic field;After being inhibited based on the detection of another three axis magnetometer Environmental magnetic field;Tested magnetic field is detected in environmental magnetic field based on a core gradiometer after inhibition, obtains carrying ring The tested magnetic field signal in border magnetic field;Tested magnetic field signal with environmental magnetic field is synthesized with the environmental magnetic field signal after inhibiting, It offsets environment magnetic field signal in the core gradiometer output signal and obtains tested fetus mcg-signals.The fetus heart magnetic of the present invention Detection probe, system and method can realize the signal detection of high s/n ratio under unshielded environment, not use screened room System cost is greatly reduced, the flexibility of system is improved, breaches the application of traditional superconducting quantum interference device magnetic detector Barrier further pushes superconducting quantum interference device systematic difference, has important economic value.So effective gram of the present invention It has taken various shortcoming in the prior art and has had high industrial utilization.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as At all equivalent modifications or change, should by the present invention claim be covered.

Claims (10)

1. a kind of fetus heart Magnetic testi probe, which is characterized in that the fetus heart Magnetic testi probe includes at least:
First three axis magnetometer, the second three axis magnetometer and core gradiometer;
First three axis magnetometer is detected the environmental magnetic field residing for the core gradiometer, and then with the described 1st The output signal driving magnetic compensation coil of axis magnetometer inhibits environmental magnetic field;
Second three axis magnetometer is detected the environmental magnetic field after inhibition;
Tested magnetic field is detected in environmental magnetic field of the core gradiometer after inhibition, the core gradiometer output letter Environmental magnetic field signal in number, which is cancelled, can be obtained measured signal.
2. fetus heart Magnetic testi probe according to claim 1, it is characterised in that:The core gradient is calculated as superconduction differential mode Coil is detected the magnetic field of first direction.
3. fetus heart Magnetic testi probe according to claim 2, it is characterised in that:Second three axis magnetometer includes three The magnetic field pick-up winding in a direction, is respectively detected the magnetic field of first direction, second direction and third direction, and described first Direction, the second direction and the third direction are vertical two-by-two.
4. fetus heart Magnetic testi probe according to claim 3, it is characterised in that:First three axis magnetometer includes three The magnetic field pick-up winding in a direction respectively carries out the magnetic field of the first direction, the second direction and the third direction Detection.
5. fetus heart Magnetic testi probe according to claim 2, it is characterised in that:In the core gradiometer superconducting line according to Symmetry axis cabling, the environmental magnetic field equilibrium area and measured signal induction zone area equation and symmetrical that symmetry axis both sides surround, Superconducting line cross wiring after symmetry axis makes the direction of winding of symmetry axis both sides superconducting line on the contrary, the line end of superconducting line is symmetrical It is drawn at axis, the magnetic flux for environmental magnetic field equilibrium area and measured signal the induction zone coupling that symmetry axis both sides surround is cancelled out each other.
6. fetus heart Magnetic testi probe according to claim 5, it is characterised in that:The environmental magnetic field equilibrium area and described High-permeability material is provided in measured signal induction zone, the relative permeability of the high-permeability material is not less than 10.
7. fetus heart Magnetic testi probe according to claim 5, it is characterised in that:The environmental magnetic field equilibrium area and described High-permeability material medium parameter having the same in measured signal induction zone.
8. fetus heart Magnetic testi probe according to claim 7, it is characterised in that:The medium parameter include magnetic conductivity, Fill space.
9. a kind of fetus heart magnetic detection system, which is characterized in that the fetus heart magnetic detection system includes at least:
Fetus heart Magnetic testi probe, SQUID sensors, coil driver, magnetic as described in claim 1~8 any one Bucking coil and noise-cancellation circuit;Wherein,
After the output end of first three axis magnetometer connects one group of SQUID sensor, connected by one group of coil driver To one group of magnetic compensation coil, magnetic compensation coil generates magnetic signal and inhibits to environmental magnetic field;
After second three axis magnetometer connects another group of SQUID sensor with the output end of the core gradiometer, it is connected to Noise-cancellation circuit, the noise-cancellation circuit are tested by what is detected in environmental magnetic field of the core gradiometer after inhibition Environmental magnetic field after the inhibition that magnetic field signal is detected with second three axis magnetometer is synthesized, and the core gradient is offset Environment magnetic field signal in output signal is counted, measured signal is obtained.
10. a kind of fetus heart magnetic detection method, which is characterized in that the fetus heart magnetic detection method includes at least:
The environmental magnetic field of fetus heart magnetic is detected based on a three axis magnetometer, and drives magnetic compensation coil to environmental magnetic field Inhibited;Environmental magnetic field after being inhibited based on the detection of another three axis magnetometer;Based on a core gradiometer after inhibition Environmental magnetic field in tested magnetic field is detected, obtain the tested magnetic field signal with environmental magnetic field;Environmental magnetic field will be carried Tested magnetic field signal with inhibit after environmental magnetic field signal synthesize, offset environmental magnetic field in the core gradiometer output signal Signal obtains tested fetus mcg-signals.
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