CN105779273A - Horizontal internal and external double-circulation airlift bioreactor - Google Patents
Horizontal internal and external double-circulation airlift bioreactor Download PDFInfo
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- CN105779273A CN105779273A CN201610265751.5A CN201610265751A CN105779273A CN 105779273 A CN105779273 A CN 105779273A CN 201610265751 A CN201610265751 A CN 201610265751A CN 105779273 A CN105779273 A CN 105779273A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
- C12M29/08—Air lift
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/24—Heat exchange systems, e.g. heat jackets or outer envelopes inside the vessel
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Abstract
The invention discloses a horizontal internal and external double-circulation airlift bioreactor. External circulation ascending pipes are symmetrically mounted on the left side and the right side of a horizontal reaction kettle body, the upper ends and the lower ends of the external circulation ascending pipes are respectively communicated with the upper part and the lower part of the horizontal reaction kettle body, air nozzles are mounted at the lower parts of the external circulation ascending pipes, external heat exchangers are mounted on the peripheries of the pipe walls of the external circulation ascending pipes, an internal circulation guide cylinder is arranged in the horizontal reaction kettle body and mounted coaxially with the center of the reaction kettle body, a plurality of sieve holes are formed in the internal circulation guide cylinder, an air distributor is arranged inside the horizontal reaction kettle body and located right below the internal circulation guide cylinder, and coaxially mounted with the horizontal reaction kettle body, the lower end of the air distributor passes through the bottom surface of the horizontal reaction kettle body to be communicated with an air inlet, and internal heat exchangers are arranged on the inner walls of the horizontal reaction kettle body. The horizontal internal and external double-circulation airlift bioreactor disclosed by the invention fundamentally solves the problems of the conventional airlift reactor of reduced rate of dissolved oxygen under high hydrostatic pressure.
Description
Technical field
The present invention relates to fermentable equipment technical field, particularly relate to a kind of horizontal internal-external double circulation airlift bioreactor.
Background technology
Most fermentable is all aerobic, but the dissolubility that oxygen is in fermentation liquid is minimum, and only 0.22mmol/L is the restrictive factor being easiest to become fermentable, leverages the carrying out of biochemical reaction.
Airlift reactor is the one of aerobic reactor, and utilization passes into the power induced effect when air in reactor rises and fermentation liquid variable density, it is achieved mash mixes；Structure is divided into internal recycle and two kinds of forms of outer circulation reactor, and its feature includes: simple in construction, energy consumption are low, save steel, operate noiselessness, dress liquid coefficient is high, be not necessary to add defoamer, maintenance operation cleans the features such as simple, minimizing miscellaneous bacteria infection.Airlift fermentor meets technological requirement and economic indicator should at least include 2 points: one is the needs that circulation time has to comply with strain fermentation；Two is the nozzle selecting suitable diameter, it is ensured that the supply of oxygen.
But, existing airlift reactor is not up to standard on circulation time when high concentration, high viscosity mash are cultivated, and causes that mash mixing is uneven, mass transfer effect is poor；The simple nozzle selecting suitable diameter also can not meet the demand to oxygen of high concentration, full-bodied mash, causes that dissolved oxygen is insufficient, and fermentation period is long.It addition, be commercially used for the big airlift reactor produced often as high as tens meters, static pressure is serious on dissolved oxygen amount impact.The present invention from the gas-liquid Blending Efficiency of Blending improving high concentration, full-bodied macro-organism consersion unit, designs a kind of high dissolved oxygen, high mass transfer, bioreactor that shearing force is little.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that a kind of horizontal internal-external double circulation airlift bioreactor.
The present invention is achieved by the following technical solutions:
nullA kind of horizontal internal-external double circulation airlift bioreactor，Including horizontal reacting kettle、Outer circulation tedge、External heat exchanger、Air nozzle、Air sparger、Built-in heat exchanger and internal recycle guide shell，The left and right sides of horizontal reacting kettle is symmetrically installed outer circulation tedge，The upper and lower side of outer circulation tedge connects with the top and the bottom of horizontal reacting kettle respectively，Outer circulation tedge bottom is provided with air nozzle，And external heat exchanger is installed in outer circulation tedge tube wall periphery，Described internal recycle guide shell is arranged at horizontal reacting kettle inside and installs with horizontal reacting kettle central coaxial，Internal recycle guide shell is provided with multiple sieve aperture，Described air sparger is arranged at horizontal reacting kettle inside and is positioned at immediately below internal recycle guide shell，It is co-axially mounted with horizontal reacting kettle，The lower end of air sparger passes the bottom surface of horizontal reacting kettle and connects with air intlet，Described built-in heat exchanger is arranged on the inwall of horizontal reacting kettle，Described air intlet is placed in the bottom of horizontal reacting kettle，It is additionally provided with discharging opening in the bottom of horizontal reacting kettle，Charging aperture and air vent it is provided with on the top of horizontal reacting kettle.The combined effect of both internal recycle guide shell and outer circulation tedge, by the change of the motive force of air and density, fermentation liquid forms two systemic circulations in reactor, makes mash mix homogeneously, it is achieved high dissolved oxygen, high mass transfer.
The diameter of each sieve aperture of described internal recycle guide shell is between 2-10mm, and becomes larger from bottom to top, and the gross area of sieve aperture accounts for the 20%-60% of internal recycle guide shell area.The gross area of sieve aperture accounts for the 20% ~ 60% of guide shell area, and the diameter of sieve aperture and the gross area are with the different adjustable of fermentative microorganism.This design makes the part incipient bubble in guide shell can be instantaneously transferred in still, increases dissolved oxygen.
Described air sparger includes horizontal seal disk, and described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.When different fermentation systems and different fermentations interim, cell concentration and oxygen demand are different, and the requirement of cycle period is also different；By adjusting the speed of air intlet, regulate and control cycle period, meet the microorganism demand to high dissolved oxygen.
Described horizontal reacting kettle is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
Described air nozzle sprays into tedge with the speed of 100～500m/s.
Described built-in heat exchanger is placed in the internal both sides of horizontal reacting kettle or side, plays the effect regulating reaction temperature, and as baffle plate, mixes fermentation liquid further.
As can be seen from the above technical solutions, the present invention passes through horizontal internal-external double circulation airlift bioreactor, adopt internal-external double circulation device and air sparger oxygen supply, including the outer circulation tedge with air nozzle, the internal recycle guide shell with different-diameter and gross area ratio, the special disc type air sparger with multiple air distribution holes and external, built-in heat exchanger.No matter the height of fermentation liquid concentration, viscosity, no matter heat is whether, this novel reactor all can make mash mass transfer, heat transfer, dissolved oxygen efficiency high, can shorten fermentation period.
The invention have the advantage that the present invention fundamentally solves in conventional airlift reactor under high static pressure, the problem that dissolved oxygen rate reduces, simultaneously, due to the design of uneven sieve aperture on the installation of outer circulation tedge air nozzle, internal recycle guide shell, and band is uniformly distributed the design of disc type air sparger in hole, the dissolved oxygen rate in each space in kettle is increased rapidly, meets fermentation needs.The present invention horizontal Two-way Cycle airlift bioreactor fundamentally solves conventional airlift reactor and is not suitable for high concentration, full-bodied fermentation system；The present invention adopts the internal-external double circulation device of outer circulation tedge and internal recycle guide shell so that fermentation liquid forms inside and outside two systemic circulations, the mixed effect of enhancing reactor inside and outside kettle；And owing to tedge is shorter, high concentration, full-bodied fermentation liquid, by the impetus of the air nozzle being positioned at tedge bottom, can quickly move through, and resistance is less.Mass transfer effect of the present invention is good, is particularly suitable for high concentration, full-bodied fermentation system.The present invention horizontal Two-way Cycle airlift bioreactor adopts double heat exchanger external, built-in, namely enhances the inside and outside heat transmission of pipe, and built-in heat exchanger as baffle plate, can strengthen mash mass transfer again；The present invention horizontal internal-external double circulation airlift bioreactor is horizontally-arranged, take up an area less, by agitating device do not realize high concentration, high viscosity fermentation system, energy consumption is little, be greatly saved cost；It addition, present configuration is simple, maintenance is convenient, workable.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention.
Fig. 2 is internal recycle guide shell structure chart of the present invention.
Detailed description of the invention
nullSuch as Fig. 1、Shown in 2，A kind of horizontal internal-external double circulation airlift bioreactor，Including horizontal reacting kettle 1、Outer circulation tedge 2、External heat exchanger 3、Air nozzle 4、Air sparger 6、Built-in heat exchanger 7 and internal recycle guide shell 5，The installation outer circulation tedge 2 that the left and right sides of horizontal reacting kettle 1 is symmetrical，The upper and lower side of outer circulation tedge 2 connects with the top and the bottom of horizontal reacting kettle 1 respectively，Outer circulation tedge 2 bottom is provided with air nozzle 4，And external heat exchanger 3 is installed in outer circulation tedge 2 tube wall periphery，Described internal recycle guide shell 5 is arranged at horizontal reacting kettle 1 inside and installs with horizontal reacting kettle 1 central coaxial，Internal recycle guide shell 5 is provided with multiple sieve aperture 12，Described air sparger 6 is arranged at horizontal reacting kettle 1 inside and is positioned at immediately below internal recycle guide shell 5，It is co-axially mounted with horizontal reacting kettle 1，The lower end of air sparger 6 passes the bottom surface of horizontal reacting kettle 1 and connects with air intlet 10，Described built-in heat exchanger 7 is arranged on the inwall of horizontal reacting kettle 1，Described air intlet 10 is placed in the bottom of horizontal reacting kettle 1，It is additionally provided with discharging opening 9 in the bottom of horizontal reacting kettle 1，Charging aperture 8 and air vent 11 it is provided with on the top of horizontal reacting kettle 1.The combined effect of both internal recycle guide shell 5 and outer circulation tedge 2, by the change of the motive force of air and density, fermentation liquid forms two systemic circulations in reactor, makes mash mix homogeneously, it is achieved high dissolved oxygen, high mass transfer.
The diameter of each sieve aperture of described internal recycle guide shell 5 is between 2-10mm, and becomes larger from bottom to top, and the gross area of sieve aperture accounts for the 20%-60% of internal recycle guide shell area.The gross area of sieve aperture accounts for the 20% ~ 60% of guide shell area, and the diameter of sieve aperture and the gross area are with the different adjustable of fermentative microorganism.This design makes the part initial bubbles in guide shell can be instantaneously transferred in still, increases dissolved oxygen.
Described air sparger 6 includes horizontal seal disk, and described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.When different fermentation systems and different fermentations interim, cell concentration and oxygen demand are different, and the requirement of cycle period is also different；By adjusting the speed of air intlet, regulate and control cycle period, meet the microorganism demand to high dissolved oxygen.
Described horizontal reacting kettle 1 is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
Described air nozzle 4 sprays into tedge with the speed of 100～500m/s.
Described built-in heat exchanger 7 is placed in the internal both sides of horizontal reacting kettle or side, plays the effect regulating reaction temperature, and as baffle plate, mixes fermentation liquid further.
Claims (6)
- null1. a horizontal internal-external double circulation airlift bioreactor，It is characterized in that: include horizontal reacting kettle、Outer circulation tedge、External heat exchanger、Air nozzle、Air sparger、Built-in heat exchanger and internal recycle guide shell，The left and right sides of horizontal reacting kettle is symmetrically installed outer circulation tedge，The upper and lower side of outer circulation tedge connects with the top and the bottom of horizontal reacting kettle respectively，Outer circulation tedge bottom is provided with air nozzle，And external heat exchanger is installed in outer circulation tedge tube wall periphery，Described internal recycle guide shell is arranged at horizontal reacting kettle inside and installs with horizontal reacting kettle central coaxial，Internal recycle guide shell is provided with multiple sieve aperture，Described air sparger is arranged at horizontal reacting kettle inside and is positioned at immediately below internal recycle guide shell，It is co-axially mounted with horizontal reacting kettle，The lower end of air sparger passes the bottom surface of horizontal reacting kettle and connects with air intlet，Described built-in heat exchanger is arranged on the inwall of horizontal reacting kettle，Described air intlet is placed in the bottom of horizontal reacting kettle，It is additionally provided with discharging opening in the bottom of horizontal reacting kettle，Charging aperture and air vent it is provided with on the top of horizontal reacting kettle.
- 2. the horizontal internal-external double circulation airlift bioreactor of one according to claim 1, it is characterized in that: the diameter of each sieve aperture of described internal recycle guide shell is between 2-10mm, and become larger from bottom to top, the gross area of sieve aperture accounts for the 20%-60% of internal recycle guide shell area.
- 3. the horizontal internal-external double circulation airlift bioreactor of one according to claim 1, it is characterized in that: described air sparger includes horizontal seal disk, described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.
- 4. the horizontal internal-external double circulation airlift bioreactor of one according to any one of claim 1-3, it is characterised in that: described horizontal reacting kettle is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
- 5. the horizontal internal-external double circulation airlift bioreactor of one according to claim 1, it is characterised in that: described air nozzle sprays into tedge with the speed of 100～500m/s.
- 6. the horizontal internal-external double circulation airlift bioreactor of one according to claim 1, it is characterised in that: described built-in heat exchanger is placed in horizontal reacting kettle both sides external or side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610265751.5A CN105779273A (en) | 2016-04-26 | 2016-04-26 | Horizontal internal and external double-circulation airlift bioreactor |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610265751.5A CN105779273A (en) | 2016-04-26 | 2016-04-26 | Horizontal internal and external double-circulation airlift bioreactor |
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| CN105779273A true CN105779273A (en) | 2016-07-20 |
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| CN201610265751.5A Pending CN105779273A (en) | 2016-04-26 | 2016-04-26 | Horizontal internal and external double-circulation airlift bioreactor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114107033A (en) * | 2021-11-19 | 2022-03-01 | 安徽宝杰生物科技有限公司 | Biological feed fermentation system with oxygen content adjusting function |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2099763U (en) * | 1991-10-12 | 1992-03-25 | 中国科学院化工冶金研究所 | Air-lift type fermentation reactor |
| CN2841645Y (en) * | 2005-09-02 | 2006-11-29 | 南京工业大学 | External circulation airlift membrane reactor |
| CN201141027Y (en) * | 2007-11-05 | 2008-10-29 | 程龙 | Inner and outer double-circulation bioreactor |
| CN101659495A (en) * | 2008-08-29 | 2010-03-03 | 北京清大国华环保科技有限公司 | Membrane distillation bioreactor device and method |
| CN101709262A (en) * | 2009-12-10 | 2010-05-19 | 中国科学院广州能源研究所 | Solar spectral photosynthetic bioreactor system for culturing microalgae in high density |
| CN204981863U (en) * | 2015-08-14 | 2016-01-20 | 浙江海洋学院 | Photobioreactor draft tube |
| CN205635573U (en) * | 2016-04-26 | 2016-10-12 | 淮南师范学院 | Horizontal inside and outside dual cycle airlift bioreactor |
-
2016
- 2016-04-26 CN CN201610265751.5A patent/CN105779273A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2099763U (en) * | 1991-10-12 | 1992-03-25 | 中国科学院化工冶金研究所 | Air-lift type fermentation reactor |
| CN2841645Y (en) * | 2005-09-02 | 2006-11-29 | 南京工业大学 | External circulation airlift membrane reactor |
| CN201141027Y (en) * | 2007-11-05 | 2008-10-29 | 程龙 | Inner and outer double-circulation bioreactor |
| CN101659495A (en) * | 2008-08-29 | 2010-03-03 | 北京清大国华环保科技有限公司 | Membrane distillation bioreactor device and method |
| CN101709262A (en) * | 2009-12-10 | 2010-05-19 | 中国科学院广州能源研究所 | Solar spectral photosynthetic bioreactor system for culturing microalgae in high density |
| CN204981863U (en) * | 2015-08-14 | 2016-01-20 | 浙江海洋学院 | Photobioreactor draft tube |
| CN205635573U (en) * | 2016-04-26 | 2016-10-12 | 淮南师范学院 | Horizontal inside and outside dual cycle airlift bioreactor |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114107033A (en) * | 2021-11-19 | 2022-03-01 | 安徽宝杰生物科技有限公司 | Biological feed fermentation system with oxygen content adjusting function |
| CN114107033B (en) * | 2021-11-19 | 2022-10-28 | 安徽宝杰生物科技有限公司 | Biological feed fermentation system with oxygen content adjusting function |
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Application publication date: 20160720 |