CN105769605A - Cosmetic containing human active hyaluronic acid or human active hyaluronate - Google Patents

Cosmetic containing human active hyaluronic acid or human active hyaluronate Download PDF

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Publication number
CN105769605A
CN105769605A CN201610259148.6A CN201610259148A CN105769605A CN 105769605 A CN105769605 A CN 105769605A CN 201610259148 A CN201610259148 A CN 201610259148A CN 105769605 A CN105769605 A CN 105769605A
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human body
acid
hyaluronate
hyaluronic acid
transparent matter
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武文博
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/002—Preparations for repairing the hair, e.g. hair cure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a cosmetic containing human active hyaluronic acid or human active hyaluronate. The composition of the cosmetic provided by the invention comprises 0.001-25 percent by mass of human active hyaluronic acid or human active hyaluronate with anti-inflammatory activity; a facial skincare cosmetic containing human active hyaluronic acid or human active hyaluronate of the invention has the anti-allergy, anti-inflammatory, anti-acne, whitening, winkle removal, water replenishment and moisturizing effects; a body-care cosmetic containing human active hyaluronic acid or human active hyaluronate has the effects of adjusting oil balance of body skin, moisturizing, whitening, antibiosis, promoting metabolism and the like; a hair-care cosmetic containing human active hyaluronic acid or human active hyaluronate has the effects of repairing hair cuticle, nourishing and toughening hair and regulating scalp oil. The human active hyaluronic acid or human active hyaluronate of the invention is prepared from processing general-efficacy hyaluronic acid with human hyaluronidase, so as to be safe and efficient.

Description

Cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate
Technical field
The invention belongs to cosmetics of everyday use and preparing technical field thereof, be specifically related to the cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate.
Background technology
Modern, in order to clean, beautify, maintain, protect face/body skin, hair, fingernail, eyes or tooth etc., usually can contact such as Cleansing Foam, makeup removing liquid, facial cream, eye cream, bath gel, shampoo, hair conditioner, toothpaste, fingernail wet goods cosmetic product.Cosmetics of everyday use on market and a feast for the eyes, class is also uneven.Along with the raising of the development of fine chemical technology and people's living standard, people are more likely to the cosmetics of everyday use that safety coefficient is higher.
Hyaluronic acid, is a kind of acid mucopolysaccharide, has the characteristics such as humectant, viscoelasticity and biocompatibility.Existing hyaluronic acid has four kinds of sources, and one is that direct animal is extracted, as extracted from buphthalmos and cockscomb；Two is that biofermentation extracts, and this is also current main method；Three is the hyaluronic acid ferment treatment general macromolecular hyaluronic acid of animal arrangement；Four is human body hyaluronic acid ferment treatment general macromolecular hyaluronic acid.The method that animal is extracted is limited due to raw material, and in raw material, hyaluronic acid contents is low, causes that yield is low, it is difficult to purify, cost is high, product quality is poor, it is difficult to large-scale production；The technique fermentation period that the method that biofermentation extracts adopts often longer, product relative molecular weight is low, product protein content is high, glucuronic acid content is low, product printing opacity rate variance, that have or even present fibrous form, not readily dissolve, also cannot be applicable to the production of cosmetics.Normal transparent matter acid is carried out enzymolysis by human body reactive transparent matter acid enzyme can obtain the acid of human body reactive transparent matter, hyaluronate can be obtained further, the acid of human body reactive transparent matter and hyaluronate not only have effect of normal transparent matter acid, and human body skin also has effect of multiple reparation.
Summary of the invention
It is an object of the invention to provide a kind of cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate, containing the face protection class cosmetics of the acid of human body reactive transparent matter or human body active hyaluronate, there is effect of antiallergic, antiinflammatory, anti-acne, whitening, smoothing wrinkle, moisturizing, moisturizing；Containing the body care class cosmetics of the acid of human body reactive transparent matter or human body active hyaluronate, there is effects such as regulating body skin oils and fats balance, moisturizing, whitening, bacteriostasis antibiosis, enhance metabolism；Wash containing the acid of human body reactive transparent matter or the hair of human body active hyaluronate and protect class cosmetics and have and repair hair scale sheet, nourish effect of tough hair quality, adjustment scalp oils and fats；The natural safety of cosmetic composition of the present invention, has no side effect, and effect is obvious.
The present invention is achieved through the following technical solutions: containing the cosmetics of the acid of human body reactive transparent matter or human body active hyaluronate, it contains mass fraction 0.001% ~ 25%, there is the acid of human body reactive transparent matter or the human body active hyaluronate of anti-inflammatory activity, the acid of described human body reactive transparent matter or human body active hyaluronate are molecular weight is 0.7KD ~ 100KD's, there is the hyaluronic acid fragments of human body activity, described human body reactive transparent matter acid fragment is that the recombined human hyaluronidase PH20 having saccharifying using Chinese hamster ovary cell to produce cuts the acquisition of macromole hyaluronic acid, and described hyaluronic acid fragments has at least one end to be the end of the recombined human hyaluronidase cutting using and can recognise that hyaluronic acid normal configuration.
Described human body active hyaluronate refers to one or more of the salt apoplexy due to endogenous wind of human body reactive transparent matter acid, preferably, described human body active hyaluronate can be one or more in hyaluronic acid, hydrolysis hyaluronic acid, hyaluronate sodium, potassium hyaluronate, hyaluronic acid ammonium.
Cosmetics of the present invention can be one or more in facial film, Cleansing Foam, sunscreen cream, bath oil, bath foam, fancy soap, makeup removing liquid, skin detergents, emollient cream, skin lotion, hair tonic preparation, hair growth promoter, hair conditioner, hair conditioner, shampoo.
Cosmetics of the present invention include following components: water, water-soluble substances, thickening agent, human body reactive transparent matter acid or human body active hyaluronate, permeation enhancers, have improve skin skin quality nutrient substance, improve the material of skin skinfeel, preservative, essence.
Described water-soluble substances can be one or more in glycerol, polyglycereol, glucose, polyethers, ethylene glycol, propylene glycol, butanediol, ethylene glycol, each seed amino acid.
Described to have the nutrient substance improving skin skin quality can be one or more in polysaccharide, aminoacid, protein, polypeptide, vitamin, primarily serves and provides nutrient for skin, improves the effect of skin quality.
The described material improving skin skinfeel can be oils and fats and esters, for instance one or more in modified grease, carbomer, starch and modified starch, cellulose and modified cellulose.
Cosmetics described in technical solution of the present invention can also add spice, pigment, pigment；Described preservative, essence, spice, pigment, the kind of pigment and consumption should be and meet the product that Cosmetic Manufacture requires.
Cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate of the present invention, typical formula can be following several.
(1) facial film containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of following components in percentage by weight: Purified Water 69.0%, carboxymethyl cellulose 5.0%, methyl hydroxybenzoate 0.2%, ethanol 5.5%, polyvinyl alcohol 15.0%, glycerol 5.0%, potassium hyaluronate 0.1%, essence 0.2%.
(2) the white class cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate, are made up of the component of following quality proportioning: PluronicL1228.0%, PluronicF1274.0%, propylene glycol 5.0%, Dormant oils 9.0%, stearic acid monoglyceride 3.0%, stearic acid 2.0%, lanoline 2.0%, hyaluronate sodium 0.1%, water 49.9%, vaseline 17.0%, spice 0.1%, Preservative qs.
(3) the cream class cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate, it is made up of the component of following quality proportioning: stearic acid 7.5%, nonionic emulsifier 4.5%, hexadecanol 4.8%, cyclopentasiloxane (DC-345) 2.3%, lanoline 5.0%, white oil 5,0%, glycerol 4.5%, 1-3 butanediol 3.0%, potassium hyaluronate 0.2%, essence are appropriate, Preservative qs, deionized water add to 100.0%.
(4) containing the acid of human body reactive transparent matter or the skin moistening fat of human body active hyaluronate, it is made up of the component of following quality proportioning: repeatedly refining mink oil 10.5%, stearic acid monoglyceride (pure) 8.0%, the polyglycol ether 3.0% of spermol stearyl alcohol, spermaceti or stearyl alcohol 2.3%, carbamide 10.0%, Polyethylene Glycol (400) 4.5%, potassium hyaluronate 0.1%, water 61.7%, Preservative qs, Fragrance qs, pigment are appropriate.
(5) skin detergents containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: stearmide alcohol 0.75%, water 69.00%, lactic acid (USP > 85%) 0.22%, denatured ethyl alcohol 4030.00%, potassium hyaluronate 0.10%, essence are appropriate, Preservative qs.
(6) the makeup removing liquid containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hexadecanol 1.00%, butyl stearate 1.25%, stearic acid 4.00%, potassium hyaluronate 0.1%, potassium hydroxide 0.15%, glycerol 0.50%, preservative, essence are appropriate, water adds to 100.0%.
(7) containing the acid of human body reactive transparent matter or human body active hyaluronate fancy soap, it is made up of the component of following quality proportioning: Adeps Bovis seu Bubali-cocos nucifera oil (50:50) soap base 75.23%, sorbitan monostearate 4.0%, coconut oil 6.73%, sodium chloride 1.06%, essence 1.24%, titanium dioxide 0.2%, potassium hyaluronate 0.1%, pigment 0.2%, water 11.34%.
(8) bath foam containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: Purified Water 70.0%, Wool wax alcohols,ethoxylated ether 5.0%, tea saponin 4.0%, methyl hydroxybenzoate 0.2%, sodium lauryl sulphate 15.0%, lauryl amidopropyl betaine 5.0%, potassium hyaluronate 0.1%, essence 0.8%, sodium chloride/pigment are appropriate.
(9) the bath oil containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: mineral oil 60.0%, polyoxyethylene (40) anhydrous sorbitol cross oleate 0.9%, isopropyl myristate 34.0%, hyaluronate sodium 0.1%, essence 5.0%.
(10) Cleansing Foam containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hyaluronate sodium 0.1%, Borax 0.1%, sodium benzoate 0.4%, white oil 40.0%, Cera Flava 5.5%, lanoline 2.5%, propylene glycol 4.0%, isopropyl myristate 4.0%, this dish-603.5%, Tween-60 3.0%, Purified Water add to 100.0%.
(11) sunscreen cream containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: glyceryl monostearate 16.0%, white oil 10.0%, Oleum sesami 10.0%, ceresine 2.0%, hexadecanol 1.0%, tert-butyl hydroxy anisole 0.02%, salicylic acid-2-Octyl Nitrite 5.0%, glycerol 7.0%, ethyl hydroxybenzoate 0.2%, essence 0.5%, hyaluronate sodium 0.1%, Purified Water add to 100.0%.
(12) shampoo containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hyaluronate sodium 0.1%, methyl hydroxybenzoate 0.15%, EDTA0.05%, polyoxyethylene lauryl ether sodium sulfate 15.0%, Tween-60 10.0%, lauric acid diethyl amide 3.0%, essence 0.5%, colorant/phosphoric acid/sodium chloride are appropriate, deionized water adds to 100.0%.
(13) hair conditioner containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hyaluronate sodium 0.1%, tween 20 1.5%, this dish-201.0%, protein 9.5%, propylene glycol 2.0%, KF88 0.1%, dodecyl dimethyl benzyl ammonium chloride 0.5%, essence 0.6%, Purified Water add to 100.0%.
(14) hair conditioner containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: glyceryl monostearate 3.0%, double; two octadecyl dimethyl amine oxide 3.0%, tannic acid 0.1%, Caulis Hederae Sinensis extract 0.3%, hyaluronate sodium 0.1%, essence 0.6%, Purified Water add to 100.0%.
(15) hair growth promoter containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hyaluronate sodium 0.1%, ethanol 17.0%, glycerol 12.5%, germanium dioxide 0.05%, essence 0.45%, Purified Water add to 100%.
(16) hair tonic preparation containing the acid of human body reactive transparent matter or human body active hyaluronate, is made up of the component of following quality proportioning: hyaluronate sodium 0.1%, boric acid 7.0%, Wool wax alcohols,ethoxylated 0.5%, citric acid 0.1%, placenta extracting liquid 0.3%, Purified Water add to 100.0%.
Normal transparent matter acid is carried out enzymolysis by the human body reactive transparent matter acid enzyme obtained by genetic engineering can obtain the acid of human body reactive transparent matter and hyaluronate, this raw material not only has effect of normal transparent matter acid, also there is human body activity, human body skin also had effect of multiple reparation:
(1) antianaphylaxis: containing the cosmetics of the acid of human body reactive transparent matter and hyaluronate, the short time can eliminate the allergic symptoms such as pruritus, makes erythema shoal；Containing human body reactive transparent matter acid and the hyaluronate present invention cosmetics can life-time service will not allergy for a long time.(2) Broadspectrum antiphlogistic；Cosmetics containing the acid of human body reactive transparent matter and hyaluronate, it is possible to strengthen human body skin oneself's maintenance function, produce the natural repair factor of a large amount of human body, such as sozin.(3) biological antibacterial peptide etc.；Cosmetics containing the acid of human body reactive transparent matter and hyaluronate, it is possible to eliminate skin eczema, the short time eliminates miliaria；Persistently use and can remove comedo or suppress the growth of comedo.(4) wrinkle removing effect: containing the cosmetics of the acid of human body reactive transparent matter and hyaluronate, it is possible to firm skin, reduces skin secretion oils and fats, removes the little wrinkle of skin.(5) white-skinned face function: containing the cosmetics of the acid of human body reactive transparent matter and hyaluronate, persistently uses and melanin can be suppressed to generate, make whiteness of skin.
The acid of human body reactive transparent matter and human body active hyaluronate can enter human skin tissue and cross-link mutually with the Natural hyaluronic acid in human body with mucosal tissue, can also be combined with human body inner recipient CD44 and TLR4, induced skin and mucosal tissue secrete antibacterial peptide and sozin, the immunity of skin and mucosa can also be improved, suppress scytitis, strengthen the antiinflammatory antiallergic ability of skin, promote the healing of damage, reach therapeutic effect, readily penetrate through skin absorption simultaneously, fill up the subcutaneous hyaluronic acid lacked, reduce wrinkle, additionally also possess the normal transparent matter all functions of acid, including moisturizing, improve skinfeel etc..
The acid of the matter of human body reactive transparent described in technical solution of the present invention or human body active hyaluronate are that the recombined human hyaluronidase PH20 having saccharifying produced with Chinese hamster ovary cell cuts the acquisition of macromole hyaluronic acid, fragment has at least one end to be the end that the recombined human hyaluronidase using and can recognise that hyaluronic acid normal configuration cuts, its molecular weight is 0.7KD ~ 100KD, has human body activity.It is used for preparing face protection class cosmetics by the acid of described human body reactive transparent matter or its esters, it is possible to play and improve face skin, removes comedo, have the function of moisturizing whitening concurrently, it is possible to effectively go down microgroove and wrinkle simultaneously；For preparing body care class cosmetics, adjustable body skin oils and fats balance, moisturizing, whitening, bacteriostasis antibiosis, the effect such as enhance metabolism；Wash and protect class cosmetics for preparing hair and have and repair hair scale sheet, nourish the function of tough hair quality, adjustment scalp oils and fats；The natural safety of cosmetic composition of the present invention, has no side effect, and effect is obvious.
Detailed description of the invention
By the examples below the present invention being described in further details, these embodiments are only used for the present invention is described, do not limit the scope of the invention.In embodiment, listed by various product formula table, hyaluronic acid, hyaluronate sodium, potassium hyaluronate are human body reactive transparent matter of the present invention acid or human body active hyaluronate (human body reactive transparent matter acid sodium, human body reactive transparent matter acid potassium).
Embodiment 1 adopts the formula of facial film containing the acid of human body reactive transparent matter or human body active hyaluronate of technical solution of the present invention as follows:
Component Content/%
Purified Water 69.0
Carboxymethyl cellulose (CMC) 5.0
Methyl hydroxybenzoate 0.2
Ethanol 5.5
Polyvinyl alcohol (PVA) 15.0
Glycerol 5.0
Potassium hyaluronate 0.1
Essence 0.2
Embodiment 2 adopts the as follows containing the acid of human body reactive transparent matter or the white class cosmetic formulations of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Pluronic L122 8.0
Pluronic F127 4.0
Propylene glycol 5.0
Dormant oils 9.0 4 -->
Stearic acid monoglyceride 3.0
Stearic acid 2.0
Lanoline 2.0
Hyaluronate sodium 0.1
Water 49.7
Vaseline 17.0
Spice 0.1
Preservative 0.1
Embodiment 3 adopts the as follows containing the acid of human body reactive transparent matter or the cream class cosmetic formulations of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Stearic acid 7.5
Nonionic emulsifier 4.5
Hexadecanol 4.8
Cyclopentasiloxane (DC-345) 2.3
Lanoline 5.0
White oil 5.0
Glycerol 4.5
1,3 butylene glycol 3.0
Potassium hyaluronate 0.2
Essence In right amount
Preservative In right amount
Deionized water Add to 100.0
Embodiment 4 adopts the as follows containing the acid of human body reactive transparent matter or the skin moistening lipid cosmetic formulations of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Repeatedly refining mink oil 10.5
Stearic acid monoglyceride (pure) 8.0
The polyglycol ether of spermol stearyl alcohol 3.0
Spermaceti or stearyl alcohol 2.3
Carbamide 10.0
Polyethylene Glycol (400) 4.0
Potassium hyaluronate 0.1
Water 61.6
Preservative, spice, pigment 0.1,0.3,0.1
Embodiment 5 adopts the as follows containing the acid of human body reactive transparent matter or the skin detergents formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Stearmide alcohol 0.50 5 -->
Water 69.00
Lactic acid (85%) 0.20
Denatured ethyl alcohol 40 30.00
Potassium hyaluronate 0.10
Essence, preservative 0.1,0.1
Embodiment 6 adopts the as follows containing the acid of human body reactive transparent matter or the makeup removing formula of liquid of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Hexadecanol 1.00
Butyl stearate 1.25
Stearic acid 4.00
Potassium hyaluronate 0.1
Potassium hydroxide 0.15
Glycerol 0.50
Water Add to 100.0
Preservative, essence In right amount
Embodiment 7 adopts the as follows containing the acid of human body reactive transparent matter or the fancy soap formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Adeps Bovis seu Bubali-cocos nucifera oil (50:50) soap base 75.20
Sorbitan monostearate 4.0
Coconut oil 6.70
Sodium chloride 1.06
Essence 1.20
Titanium dioxide 0.2
Potassium hyaluronate 0.1
Pigment 0.2
Water 11.34
Embodiment 8 adopts the as follows containing the acid of human body reactive transparent matter or the body wash liquid formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Purified Water 70.0
Wool wax alcohols,ethoxylated ether 5.0
Tea saponin 4.0
Methyl hydroxybenzoate 0.2
Sodium lauryl sulphate 15.0
Lauryl amidopropyl betaine 5.0
Potassium hyaluronate 0.1
Essence 0.5 6 -->
Sodium chloride, pigment 0.1,0.1
Embodiment 9 adopts the as follows containing the acid of human body reactive transparent matter or the bath oil formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Mineral oil 60.0
Polyoxyethylene (40) anhydrous sorbitol crosses oleate 0.9
Isopropyl myristate 34.0
Hyaluronate sodium 0.1
Essence 5.0
Embodiment 10 adopts the as follows containing the acid of human body reactive transparent matter or the Cleansing Foam formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Borax 0.1
Sodium benzoate 0.4
White oil 40.0
Cera Flava 5.5
Lanoline 2.5
Propylene glycol 4.0
Isopropyl myristate 4.0
This dish-60(Span-60) 3.5
Tween-60 (Tween-60) 3.0
Hyaluronate sodium 0.1
Purified Water Add to 100.0
Embodiment 11 adopts the as follows containing the acid of human body reactive transparent matter or the formula of sun screen of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Glyceryl monostearate 16.0
White oil 10.0
Oleum sesami 10.0
Ceresine 2.0
Hexadecanol 1.0
Tert-butyl hydroxy anisole 0.02
Salicylic acid-2-Octyl Nitrite 5.0
Glycerol 7.0
Ethyl hydroxybenzoate 0.2
Essence 0.5
Hyaluronate sodium 0.1
Purified Water Add to 100.0
Embodiment 12 adopts the as follows containing the acid of human body reactive transparent matter or the shampoo formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Methyl hydroxybenzoate 0.15
EDTA 0.05
Polyoxyethylene lauryl ether sodium sulfate 15.0
Tween-60 10.0
Lauric acid diethyl amide 3.0
Hyaluronate sodium 0.1
Essence 0.5
Colorant, phosphoric acid, sodium chloride In right amount
Deionized water Add to 100.0
Embodiment 13 adopts the as follows containing the acid of human body reactive transparent matter or the hair conditioning agent prescription of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Tween 20 1.5
This dish-20 1.0
Protein 9.5
Propylene glycol 2.0
KF88 0.1
Dodecyl dimethyl benzyl ammonium chloride 0.5
Hyaluronate sodium 0.1
Purified Water Add to 100.0
Essence 0.6
Embodiment 14 adopts the as follows containing the acid of human body reactive transparent matter or the hair conditioner formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Glyceryl monostearate 3.0
Double; two octadecyl dimethyl amine oxides 3.0
Tannic acid 0.1
Caulis Hederae Sinensis extract 0.3
Hyaluronate sodium 0.1
Essence 0.6
Purified Water Add to 100.0
Embodiment 15 adopts the as follows containing the acid of human body reactive transparent matter or the hair growth promoter formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Purified Water Add to 100.0
Ethanol 17.0
Glycerol 12.5 8 -->
Germanium dioxide 0.05
Hyaluronate sodium 0.1
Essence 0.45
Embodiment 16 adopts the as follows containing the acid of human body reactive transparent matter or the hair tonic preparation formula of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Purified Water Add to 100.0
Boric acid 7.0
Wool wax alcohols,ethoxylated 0.5
Citric acid 0.1
Placenta extracting liquid 0.3
Hyaluronate sodium 0.1
Embodiment 17 adopts the as follows containing the acid of human body reactive transparent matter or the formulation of tooth-paste of human body active hyaluronate of technical solution of the present invention:
Component Content/%
Phosphoric acid hydrogen dihydrate 45
Silicon dioxide 2
Glycerol 10
Sorbitol 10
Carboxymethyl cellulose 1
Thallus Gracilariae 0.3
Sodium laurylsulfate 1.6
The acid of human body reactive transparent matter or human body active hyaluronate 0.1
Essence 1
Saccharin sodium In right amount
Purified Water Add to 100.0
Embodiment 18 adopts the as follows containing the acid of human body reactive transparent matter or the cream class cosmetic formulations of human body active hyaluronate of technical solution of the present invention:
Component Content %
Octadecanoic stearic 10
Hexadecanoic palmitic 10
Tetradecanoic acid myristic acid 12
Dodecylic acid lauric acid 4
Oleyl alcohol 1.5
Lanolin derivative 1.0
Spice 0.5
Glycerol 18
Potassium hydroxide 6
Potassium hyaluronate 0.001 9 -->
Distilled water Add to 100
Preservative In right amount
Embodiment 19 adopts the as follows containing the acid of human body reactive transparent matter or the white class formula of human body active hyaluronate of technical solution of the present invention:
Component Content %
Stearic acid 10.0
Palmic acid 10.0
Tetradecylic acid 12.0
Lauric acid 5.0
Potassium hydroxide 7.0
Propylene glycol 10.0
Polyethylene Glycol 5.0
Glycerol 5.0
Cera Flava 1.0
Lanoline 1.0
Glyceryl monostearate 2.0
Polyethers 1.0
Spice 0.7
Hydroxyalkyl vinyl copolymer 0.3
Hyaluronate sodium 25.0
Water Add to 100.0
Embodiment 20 adopts the as follows containing the acid of human body reactive transparent matter or the cleansing milk formula of human body active hyaluronate of technical solution of the present invention:
Component Content %
Alkyl betaine 30.0
Nonionic surfactant 0.0
Octadecanol ethylene oxide condensate 0.7
Lanolin derivative 1.0
Methyl hydroxybenzoate 0.2
Propylparaben 0.2
Propylene glycol 1.5
Tetraalkyl amino hectorite 3.0
Glycerol 1.0
Organic silicone oil 0.30
Thickening agent 1.0
Hyaluronic acid 10.0
Water Add to 100.00

Claims (4)

1. the cosmetics containing the acid of human body reactive transparent matter or human body active hyaluronate, it is characterized in that: containing mass fraction 0.001% ~ 25%, there is the acid of human body reactive transparent matter or the human body active hyaluronate of anti-inflammatory activity, described human body reactive transparent matter acid is molecular weight is the human body reactive transparent matter acid fragment of 0.7KD ~ 100KD, described human body reactive transparent matter acid fragment is that the recombined human hyaluronidase PH20 having saccharifying using Chinese hamster ovary cell to produce cuts the acquisition of macromole hyaluronic acid, and described hyaluronic acid fragments has at least one end to be the end of the recombined human hyaluronidase cutting using and can recognise that hyaluronic acid normal configuration.
2. cosmetics according to claim 1, it is characterised in that: described human body active hyaluronate is one or more of the salt apoplexy due to endogenous wind of human body reactive transparent matter acid.
3. cosmetics according to claim 1 and 2, it is characterised in that: described human body active hyaluronate is one or more in hyaluronic acid, hydrolysis hyaluronic acid, hyaluronate sodium, potassium hyaluronate, hyaluronic acid ammonium.
4. cosmetics according to claim 1, it is characterised in that: described cosmetics are one or more in facial film, Cleansing Foam, sunscreen cream, bath oil, bath foam, fancy soap, makeup removing liquid, skin detergents, emollient cream, skin lotion, hair tonic preparation, hair growth promoter, hair conditioner, hair conditioner, shampoo.
CN201610259148.6A 2016-04-25 2016-04-25 Cosmetic containing human active hyaluronic acid or human active hyaluronate Pending CN105769605A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309401A (en) * 2016-10-14 2017-01-11 杭州惠博士生物科技有限公司 Bathing effervescent tablets for preventing and treating skin diseases
CN107174535A (en) * 2017-04-18 2017-09-19 杭州惠博士健康产业有限公司 A kind of hyaluronic acid compositions and application with the transdermal reparation effect of anti-inflammatory
CN107184427A (en) * 2017-04-17 2017-09-22 杭州惠博士健康产业有限公司 A kind of cooperative compositions and application containing polyglutamic acid and hyaluronic acid
CN107496195A (en) * 2017-08-01 2017-12-22 杭州惠博士健康产业有限公司 A kind of recombined human hyaluronic acid compositions and its application in cosmetics
FR3064473A1 (en) * 2017-04-03 2018-10-05 Basf Beauty Care Solutions France Sas PROTECTIVE INGREDIENT FOR THE BALANCE OF THE MICROBIAL SKIN FLORA AND / OR MUCOSAL
WO2021129617A3 (en) * 2019-12-26 2021-10-07 华熙生物科技股份有限公司 Topical composition for preventing, alleviating, or treating skin allergies, and use therefor

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CN104546896A (en) * 2015-02-09 2015-04-29 惠觅宙 Bioactive hyaluronic acid gel preparation
CN104971349A (en) * 2015-06-16 2015-10-14 惠觅宙 Externally used compound preparation
CN105018547A (en) * 2014-04-16 2015-11-04 惠觅宙 Bioactive hyaluronic acid fragment, production method, application, preparation and object containing preparation

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Publication number Priority date Publication date Assignee Title
CN105018547A (en) * 2014-04-16 2015-11-04 惠觅宙 Bioactive hyaluronic acid fragment, production method, application, preparation and object containing preparation
CN104546896A (en) * 2015-02-09 2015-04-29 惠觅宙 Bioactive hyaluronic acid gel preparation
CN104971349A (en) * 2015-06-16 2015-10-14 惠觅宙 Externally used compound preparation

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309401A (en) * 2016-10-14 2017-01-11 杭州惠博士生物科技有限公司 Bathing effervescent tablets for preventing and treating skin diseases
FR3064473A1 (en) * 2017-04-03 2018-10-05 Basf Beauty Care Solutions France Sas PROTECTIVE INGREDIENT FOR THE BALANCE OF THE MICROBIAL SKIN FLORA AND / OR MUCOSAL
WO2018185408A1 (en) * 2017-04-03 2018-10-11 Basf Beauty Care Solutions France Sas Protective ingredient for balancing the cutaneous and/or mucosal microbial flora
CN107184427A (en) * 2017-04-17 2017-09-22 杭州惠博士健康产业有限公司 A kind of cooperative compositions and application containing polyglutamic acid and hyaluronic acid
CN107174535A (en) * 2017-04-18 2017-09-19 杭州惠博士健康产业有限公司 A kind of hyaluronic acid compositions and application with the transdermal reparation effect of anti-inflammatory
CN107496195A (en) * 2017-08-01 2017-12-22 杭州惠博士健康产业有限公司 A kind of recombined human hyaluronic acid compositions and its application in cosmetics
WO2021129617A3 (en) * 2019-12-26 2021-10-07 华熙生物科技股份有限公司 Topical composition for preventing, alleviating, or treating skin allergies, and use therefor

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Application publication date: 20160720