CN105769126A - LED optical system for dynamic optical medical functional imaging - Google Patents
LED optical system for dynamic optical medical functional imaging Download PDFInfo
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- CN105769126A CN105769126A CN201610207894.0A CN201610207894A CN105769126A CN 105769126 A CN105769126 A CN 105769126A CN 201610207894 A CN201610207894 A CN 201610207894A CN 105769126 A CN105769126 A CN 105769126A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
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Abstract
The invention relates to the technical field of advanced optical medical diagnostic equipment and optoelectronics, in particular to an LED optical system for dynamic optical medical functional imaging, comprising an LED module for receiving image camera synchronous signals and computer control signals, the LED module comprises a control circuit, a drive circuit and a plurality of arrayed infrared diode light sources, the control circuit controls the diode light sources through the drive circuit, the drive circuit comprises a row drive circuit for selecting transverse coordinates of light-emitting diode light sources and a column drive circuit for selecting longitudinal coordinates of the light-emitting diode light sources.The LED optical system provides light for a whole imaging system, a lighting zone of the LED optical system can be automatically adjusted as required, and internal physiological and pathological information of a human body by acquiring permeating light or reflected light of tissues under detection.
Description
Technical field
The present invention relates to advanced optics medical diagnostic apparatus and photoelectron technical field, particularly relate to the LED optical system of a kind of dynamic optical medical science functional imaging.
Background technology
Dynamic optical medical science functional imaging is diagnosis tissue early cancer's pathological changes, particularly an emerging formation method of early stage Benign And Malignant Breast Diseases.Dynamic optical medical science functional imaging technology predominantly detects the blood volume in tissue and this two big feature of high metabolic rate.Meanwhile, different between dynamic optical medical science functional imaging technology for detection human lesion and normal structure, i.e. only blood around detection tumor, and do not detect the blood of normal structure.Dramatically different with other optical imaging method is that dynamic optical medical science functional imaging system generates Dynamic Signal by the method for mechanical disturbance, extracts physiologic information and the functional parameter of detected tissue.Light emitting diode (LED) array of dynamic optical medical science functional imaging system irradiates the blood capillary region with possibility malignant tumor characteristic.In neo-angiogenesis process, malignant tumor can form intensive capillary network about.The existence that these blood capillaries are tumor provides oxygen and nutrient, they also show the physiological marker of the malignant tumor that dynamic optical medical image system can detect simultaneously, it is intensive that these physiological marker include vascularity, resistance of blood flow is big, blood deoxidation degree is high, optical transport is decayed by force, and vascular permeability is stronger etc. under external pressure.
Max. card Teller (MaxCutler) takes the lead in proposing mammary gland optical image technology in nineteen twenty-nine.He make use of one to be called " transillumination (photography) " technology, and mammary gland tissue is had an X-rayed.This technology present red light through normal structure and through close on cancer cardiovascular generate tissue time significantly different.In recent years, American Studies personnel S.Ertefal and A.Edwardo utilizes the mammary gland tissue taken off to represent the blood contents (deoxyhemoglobin) impact on the optical transmittance (spectral absorption) in mammary gland tissue.Meanwhile, research worker also observe the detection of two waveband system to making a gesture of measuring, and it was found that measurement result and band oxygen hemoglobin and deoxyhemoglobin model have good dependency.They find that the mean concentration of the erythrocyte of cancer edge and cancer surrounding tissue is higher than normal structure.The result of " perspective imaging " shows optical contrast ratio and " concentration of hemoglobin (erythrocyte) has very strong dependency in cancer and fibromatous subgroup tissue ", can observe spectral absorption at 600-900nm (nanometer) wave band.Other scholars and research worker are investigated the transmission of the spectrum at 500-1100nm, reflection, scattering and absorbance, and find that only Oxygenated blood Lactoferrin and moisture are the information that can definitely provide SPECTRAL DIVERSITY.
A few days ago, applicant has been filed on the Chinese patent application that a application number is " 201410828085.2 ", this earlier application relates to the image-taking system of a kind of breast cancer diagnosis apparatus, mammary gland is applied equally distributed pressure by air bag by this image-taking system orders about blood content and deoxyhemoglobin generation significantly change, and obtained after dynamic image through computer disposal by ccd video camera, can show that blood volume and deoxyhemoglobin feature over time over the display.
As shown in Figure 1 and Figure 2, the visible HONGGUANG pulse that LED illumination System sends absorbs through mammary gland tissue, and part is received by CCD camera through the photon of mammary gland, by dynamic optical breast imaging algorithm, finally shows the dynamic image of mammary gland tissue in a computer.As it is shown on figure 3, the major function of LED optical system is that CCD camera assembly provides light source for whole imaging system in conjunction with controller assemblies in dynamic optical breast imaging system.If the light of instability enters CCD camera, this will cause image saturated and deterioration in image quality, cause that system cannot normally detect, so the quality of LED optical system, whole dynamic optical breast carcinoma of early stage diagnostic system is played a major role, and the acquisition of whole raw image data decides the whether effective of breast cancer.
Summary of the invention
In order to solve the problems referred to above, it is an object of the invention to provide a set of dynamic optical medical science functional imaging LED optical system, this LED optical system provides light source for whole imaging system, the illumination interval of LED optical system can adjust as required automatically, and accurately obtain physiology and the pathological information of inside of human body by gathering the detected transmission light organized or reflection light.
In order to realize above-mentioned purpose, present invention employs following technical scheme:
A kind of LED optical system of dynamic optical medical science functional imaging, including the LED component for receiving image camera synchronizing signal and computer control signal, it is characterized in that: described LED component includes control circuit, drive circuit and some array arrangement infrared diode light sources, control circuit controls diode light-source by drive circuit, drive circuit includes the horizontal drive circuit for selecting LED source lateral coordinates, and is used for selecting LED source longitudinal coordinate column drive circuit.
As preferably, described LED component also includes feedback circuit, and feedback circuit and control circuit, drive circuit are respectively connected with；Feedback circuit compares in order to the output signal of the signal fed back by drive circuit and control circuit, regulates the electric current by diode light-source by comparative result.In said structure, the signal fed back by drive circuit by feedback circuit and the output signal of control circuit are compared, thus adjusting the size of current by diode light-source, it is achieved the automatic brightness adjustment of diode light-source, thus providing stable for whole system, adjustable smooth source size.
As preferably, described LED component also includes serial ports optical coupling isolation circuit, serial ports optical coupling isolation circuit includes the interface J7 for being connected with image camera, and the interface P2 for being connected with personal computer, it is connected between serial ports optical coupling isolation circuit and control circuit and by photoelectrical coupler electrical isolation.In said structure, between LED board and PC, there is good electrical isolation, can ensure that LED board is not damaged because PC serial ports damages first；Second the conversion between varying level can be carried out.
As preferably, described infrared diode light source is 8 row 16 column matrix arrangements；Including 3 bars transmission lines between described control circuit and horizontal drive circuit, 3 bars transmission lines switch to horizontal drive circuit by decoder U48, and horizontal drive circuit has 8 row circuit, are provided with NAND gate and semiconductor field effect transistor in every row circuit；Including 4 bars transmission lines between described control circuit and column drive circuit, 4 bars transmission lines switch to column drive circuit by decoder U55, and column drive circuit has 16 column circuits, is provided with NAND gate and semiconductor field effect transistor in every column circuits.Above-mentioned drive circuit is mainly used in driving LED array lamp, provides operating current to LED so that it is luminous.Because infrared diode light source is 8 row 16 column matrix arrangements, drive circuit is divided into horizontal drive circuit and column drive circuit, decoder U48 and decoder U55 is for becoming analogue signal by the two-stage system code translation that control circuit inputs, the infrared diode being selected which row by horizontal drive circuit works, column drive circuit select which diode light-source work of changing one's profession.
As preferably, the optical source wavelength of described diode light-source is at 620nm～685nm, owing to observing that at 620-685 nano waveband the spectral absorption of aerobic blood and anaerobic blood has obvious difference, the red visible that light source is 620nm～685nm that therefore illuminator is useful.
As preferably, described feedback circuit includes comparator, sampling resistor R104, and with the sampling resistor R104 Mos pipe Q4 being in series, the output signal of control circuit outfan DAC-OUT and sampling resistor R104 are connected to comparator two ends, comparator, by the output signal of control circuit and the contrast of sampling resistor R104 both end voltage, controls the conducting situation of Mos pipe Q4；Feedback circuit in said structure is by the contrast of the output signal of control circuit with sampling resistor R104 both end voltage, by the height of voltage, control the conducting situation of Mos pipe Q4, thus adjusting the size of current by diode light-source, realize the automatic brightness adjustment of diode light-source, thus providing stable for whole system, adjustable light source.
As preferably, described control circuit includes main control unit and the digital to analog converter being connected with main control unit, and the outfan DAC-OUT of digital to analog converter is connected with feedback circuit.
The present invention adopts technique scheme, and the LED optical system of this dynamic optical medical science functional imaging includes the LED component for receiving image camera synchronizing signal；During use, LED component receives the shutter signal of image camera, control circuit in LED component drives diode light-source work by drive circuit or closes, and the diode light-source of horizontal drive circuit in drive circuit and the optional different coordinates of column drive circuit is operated, the illumination interval realizing LED optical system can adjust as required automatically, and accurately obtain physiology and the pathological information of inside of human body by gathering the detected transmission light organized or reflection light.
Accompanying drawing explanation
Fig. 1 is dynamic optical mammary gland tissue image-forming principle one.
Fig. 2 is dynamic optical mammary gland tissue image-forming principle two.
Fig. 3 is LED illuminator block component diagram.
Fig. 4 is the optical characteristics of tissue.
Fig. 5 is LED hardware circuit diagram.
Fig. 6 is the front end circuit figure (including serial ports optical coupling isolation circuit, power supply input adjustment circuit and control circuit) of the present invention.
Fig. 7 is Tu6Zhong I district enlarged drawing, i.e. serial ports optical coupling isolation circuit.
Fig. 8 is Tu6Zhong II district enlarged drawing, i.e. power supply input adjustment circuit.
Fig. 9 is Tu6Zhong III district enlarged drawing, control circuit.
Figure 10 is horizontal drive circuit.
Figure 11 is column drive circuit.
Figure 12 is feedback circuit.
Figure 13 is LED matrix circuit.
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the invention are described in further detail.
The LED optical system of a kind of dynamic optical medical science functional imaging as shown in Fig. 5～13, this LED optical system provides light source for whole imaging system, the illumination interval of LED optical system can adjust as required automatically, and accurately obtain physiology and the pathological information of inside of human body by gathering the detected transmission light organized or reflection light.
Above-mentioned LED optical system includes the LED component for receiving image camera synchronizing signal, this LED component includes serial ports optical coupling isolation circuit, power supply input adjustment circuit, control circuit, drive circuit, feedback circuit, and some array arrangement infrared diode light sources, i.e. LED array lamp, the concrete structure of each parts is as follows
1, serial ports optical coupling isolation circuit；
Serial ports optical coupling isolation circuit is used for electrical isolation PC end signal protection LED circuit board, can ensure that LED board is not damaged because PC serial ports damages first；Second the conversion between varying level can be carried out.As shown in Figure 7; serial ports optical coupling isolation circuit includes the interface J7 for being connected with image camera; and the interface P2 for being connected with personal computer; it is connected between serial ports optical coupling isolation circuit and control circuit and by photoelectrical coupler electrical isolation; as shown in FIG.; ISO1D, ISO1B and ISO1C are the main control units that photoelectrical coupler is connected to control circuit, carry out electrical isolation, and effect is protection LED circuit board.
2, power supply input adjustment circuit；
As shown in Figure 8: J5 is external power source input interface, the external power supply being provided+12V by controller, through adjustable voltage stabilizing chip U37, output 9V is for providing power supply to LED；And+12V power supply another side becomes 5V by voltage stabilizing chip U29 voltage stabilizing, provide power supply to micro-control circuit.
3, control circuit；
Control circuit is responsible for the serial communication between homologous ray computer control drive circuit processed so that it is work.Instruction according to component computer, dynamically controls LED array lamp. and control the fluorescent lifetime of LED array lamp, luminous pattern, luminosity, and receive the triggering signal from CCD camera.Master controller it be made up of the High Performance SCM MC68HC908MR32 of Motorola, it has the following characteristics that the flash storage of 32K, the RAM of 768 bytes, 10 10, tunnel A/D, the PWM module on 12, one six tunnel, there are 3 current detecting inputs and 4 rub-out signal inputs, one serial communication interface (SCI) and a serial peripheral interface (SPI), one 4 tunnel 16 bit timing device system, Clock generation module, can be produced various high frequency internal clockings by lower frequency crystal oscillator.
As it is shown in figure 9, control circuit includes main control unit and the digital to analog converter being connected with main control unit.In figure, U28 is exactly single-chip microcomputer is main control unit；U34 is that digital to analog converter converts analog signals to digital signal, for controlling the electric current of LED；U32 is power supply, provides reference voltage for digital to analog converter；JP3 is software download interface, is used for downloading Single Chip Microcomputer (SCM) program.
4, drive circuit；
Control circuit controls diode light-source by drive circuit, provides operating current to LED so that it is luminous.Drive circuit includes the horizontal drive circuit for selecting LED source lateral coordinates, and is used for selecting LED source longitudinal coordinate column drive circuit.
4.1, horizontal drive circuit；
As shown in Figure 10,3 bars transmission lines are included between control circuit and horizontal drive circuit, 3 bars transmission lines switch to horizontal drive circuit by decoder U48, and horizontal drive circuit has 8 row circuit, are provided with NAND gate and semiconductor field effect transistor (MOSFET) in every row circuit；Decoder U48, for the two-stage system code translation that control circuit inputs is become analogue signal, is selected the infrared diode of which row to work by horizontal drive circuit.
4.2, horizontal drive circuit；
As shown in figure 11,4 bars transmission lines are included between control circuit and column drive circuit, 4 bars transmission lines switch to column drive circuit by decoder U55, column drive circuit has 16 column circuits, NAND gate and semiconductor field effect transistor it is provided with in every column circuits, decoder U55, for the two-stage system code translation that control circuit inputs is become analogue signal, is selected, by column drive circuit, which diode light-source work of changing one's profession.
5, feedback circuit；
Feedback circuit and control circuit, drive circuit are respectively connected with；Feedback circuit compares in order to the output signal of the signal fed back by drive circuit and control circuit, regulates the electric current by diode light-source by comparative result.In said structure, the signal fed back by drive circuit by feedback circuit and the output signal of control circuit are compared, thus adjusting the size of current by diode light-source, it is achieved the automatic brightness adjustment of diode light-source, thus providing stable for whole system, adjustable light source.As shown in figure 12, feedback circuit includes comparator, sampling resistor R104, and with the sampling resistor R104 Mos pipe Q4 being in series.The output signal of control circuit outfan DAC-OUT and sampling resistor R104 are connected to comparator two ends, and comparator, by the output signal of control circuit and the contrast of sampling resistor R104 both end voltage, controls the conducting situation of Mos pipe Q4；Feedback circuit in said structure is by the contrast of the output signal of control circuit with sampling resistor R104 both end voltage, by the height of voltage, control the conducting situation of Mos pipe Q4, thus adjusting the size of current by diode light-source, realize the automatic brightness adjustment of diode light-source, thus providing stable for whole system, adjustable light source.
The working condition of above-mentioned feedback circuit includes following situation: (wherein, VR104 refers to sampling resistor R104 both end voltage)
1, when the electric current of diode light-source increases, causing that the electric current on sampling resistor R104 increases, now audion Q6 conducting, so that Q4 turns off, realizing overcurrent protection thus protecting.
2, the digital to analog converter of main control exporting DAC_OUT is a magnitude of voltage, by the voltage ratio on same R104 relatively, if output voltage>VR104, then Q4 conducting, if<VR104, then Q4 turns off output voltage, carries out overvoltage protection；
3, the electric current of diode light-source is VR104/1ohm；
4, increase in resistance R104 both end voltage, but during for making Q6 turn on, the size of DAC_OUT sets the electric current flowing through diode light-source.
6, array infrared diode light source；
The light wave of 6.1, LED selects；
As shown in Figure 4, observe that the spectral absorption of aerobic blood and anaerobic blood has obvious difference at 620-685 nano waveband, the red visible that light source is 620nm～685nm that therefore illuminator is useful, it is preferable that operation wavelength is 627nm.
6.2, LED array；
LED array lamp is arranged in the light source when LED array lamp of udder shape pattern is mainly used in providing breast examination, and whether its work is by LED drive circuit control.As shown in figure 13, LED matrix lamp is made up of 8 row 16 row, but only need to use 127 lamps owing to forming a udder shape when system designs, and therefore useful 3 Diode series form a dummy load here, make matrix lamp circuit balancing.
6.3, the logical address of LED array lamp
7, summary；
In the LED optical system of this dynamic optical medical science functional imaging, LED component is for receiving the operational order of image camera synchronizing signal and computer.During use, LED component receives the shutter signal of image camera, control circuit in LED component drives diode light-source work by drive circuit or closes, and the diode light-source of horizontal drive circuit in drive circuit and the optional different coordinates of column drive circuit is operated, the illumination interval realizing LED optical system can adjust as required automatically, and accurately obtain physiology and the pathological information of inside of human body by gathering the detected transmission light organized or reflection light.
Claims (7)
1. the LED optical system of a dynamic optical medical science functional imaging, including the LED component for receiving image camera synchronizing signal and computer control signal, it is characterized in that: described LED component includes control circuit, drive circuit and some array arrangement infrared diode light sources, control circuit controls diode light-source by drive circuit, drive circuit includes the horizontal drive circuit for selecting LED source lateral coordinates, and is used for selecting LED source longitudinal coordinate column drive circuit.
2. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 1, it is characterised in that: described LED component also includes feedback circuit, and feedback circuit and control circuit, drive circuit are respectively connected with；Feedback circuit compares in order to the output signal of the signal fed back by drive circuit and control circuit, regulates the size of current by diode light-source by comparative result.
3. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 1 and 2, it is characterized in that: described LED component also includes serial ports optical coupling isolation circuit, serial ports optical coupling isolation circuit includes the interface J7 for being connected with image camera, and the interface P2 for being connected with personal computer, it is connected between serial ports optical coupling isolation circuit and control circuit and by photoelectrical coupler electrical isolation.
4. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 3, it is characterised in that: described infrared diode light source is 8 row 16 column matrix arrangements；Including 3 bars transmission lines between described control circuit and horizontal drive circuit, 3 bars transmission lines switch to horizontal drive circuit by decoder U48, and horizontal drive circuit has 8 row circuit, are provided with NAND gate and semiconductor field effect transistor in every row circuit；Including 4 bars transmission lines between described control circuit and column drive circuit, 4 bars transmission lines switch to column drive circuit by decoder U55, and column drive circuit has 16 column circuits, is provided with NAND gate and semiconductor field effect transistor in every column circuits.
5. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 4, it is characterised in that: the optical source wavelength of described diode light-source is at 620nm～685nm.
6. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 4, it is characterized in that: described feedback circuit includes comparator, sampling resistor R104, and with the sampling resistor R104 Mos pipe Q4 being in series, the output signal of control circuit outfan DAC-OUT and sampling resistor R104 are connected to comparator two ends, comparator, by the output signal of control circuit and the contrast of sampling resistor R104 both end voltage, controls the conducting situation of Mos pipe Q4.
7. the LED optical system of a kind of dynamic optical medical science functional imaging according to claim 6, it is characterized in that: described control circuit includes main control unit, and the digital to analog converter being connected with main control unit, the outfan DAC-OUT of digital to analog converter is connected with feedback circuit.
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| CN201610207894.0A CN105769126A (en) | 2016-04-05 | 2016-04-05 | LED optical system for dynamic optical medical functional imaging |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109907735A (en) * | 2019-04-25 | 2019-06-21 | 北京峰云视觉技术有限公司 | A kind of multispectral tongue image acquisition equipment |
| CN113180601A (en) * | 2021-04-27 | 2021-07-30 | 浙江杜比医疗科技有限公司 | Tumor feature analysis device for dynamic optical breast imaging and related components |
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Application publication date: 20160720 |