CN105758848B - A kind of incubation magnetic separating device applied to chemical luminescent detecting - Google Patents
A kind of incubation magnetic separating device applied to chemical luminescent detecting Download PDFInfo
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- CN105758848B CN105758848B CN201610102336.8A CN201610102336A CN105758848B CN 105758848 B CN105758848 B CN 105758848B CN 201610102336 A CN201610102336 A CN 201610102336A CN 105758848 B CN105758848 B CN 105758848B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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Abstract
The invention discloses a kind of incubation magnetic separating devices applied to chemical luminescent detecting, belong to chemical luminescent detecting field.A kind of incubation magnetic separating device applied to chemical luminescent detecting, including incubating device and magnetic separating device；The magnetic separating device is set on the side for incubating device, ensures that the magnet in magnet frame corresponds to the bottom sides of the reaction cup in reaction cup aperture.The present invention, which integrates, incubates function, Magneto separate function, and temperature range, the magnetic separation time is accurately adjustable, which stablizes, easy to operate.It incubates device to directly heat using contact, incubation effect is good, and magnetic separating device has many advantages, such as buffering effect and reduces magnetic bead loss.
Description
Technical field
The present invention relates to chemical luminescent detecting field more particularly to a kind of incubation Magneto separates applied to chemical luminescent detecting
Device.
Background technology
The incubation device of the prior art is mostly the incubation of rotating disc type, mostly using mode of heatings such as air baths, heating speed compared with
Slowly, and by extraneous factor influenced very greatly, temperature fluctuation is larger, can seriously affect incubation reaction, then influence measurement result.
Meanwhile the conducting wire being connected in incubation device with heating unit is more, and circuit easily occurs during dial movement
Winding, causes mechanical disorder, influences working efficiency.
Magnetic separating device of the prior art be typically all magnet is completely fixed in magnet fixed block, cause magnet with
Reaction cup does not have elasticity setting when contacting but very stiff and demanding collision, can cause very big impact to the wall of cup of reaction cup in this way,
Even can reaction cup be ruptured when serious.
In addition, Magneto separate is usually to be carried out in reaction cup bottom, and the bottom of reaction cup is all in same height, magnetic point
From after the completion, liquid pumping needle intercalation reaction bottom of a cup portion drawing liquid during cleaning, while easily take magnetic bead away, magnetic bead is caused to be lost in serious.
Invention content
Problem to be solved:In view of the above problems, a kind of contact of present invention offer directly heats, incubation effect is good, has
There is buffering effect and reduce the incubation magnetic separating device that magnetic bead is lost in.
For solution more than technical problem, the present invention adopts the following technical scheme that：
A kind of incubation magnetic separating device applied to chemical luminescent detecting, including incubating device and magnetic separating device；
The incubation device incubates disk, conducting slip ring, rotary tray motor, heating plate, temperature sensor, stent, described
It incubates disk to be set on stent, the back side of the incubation disk is equipped with heating plate and temperature sensor；The conducting slip ring is set on
The conducting wire of the center of incubation disk, heating plate and temperature sensor is wrapped on conducting slip ring；The rotation of the rotary tray motor
Axis is connected with the center for incubating disk；The round edge of the incubation disk is equipped with several reaction cup aperture；
The magnetic separating device includes moving forward and backward motor, pushing meanss, magnet frame, magnet, magnet fixed block, magnetic point
From stent, pedestal, spring assembly, the magnet frame is connected by pushing meanss with moving forward and backward motor, and magnet frame is equipped with
Several magnetic receivers, the magnet fixed block are set in magnetic receiver, and the magnet is set in magnet fixed block and acts on simultaneously
Close at bottom, move forward and backward motor, pushing meanss and the magnet frame are set on Magneto separate stent for the side of reaction cup,
The Magneto separate branch is set up on pedestal, and the spring assembly is set on inside magnetic receiver, and behind magnet fixed block；
Magnet of the magnet frame on the side for incubating disk, magnet frame corresponds to the bottom of the reaction cup in reaction cup aperture
Portion side.
Further technical solution, the incubation device further include drip tray, and the drip tray, which is located at, incubates disk
In the following, and positioned at the underface of reaction cup aperture.
Further technical solution, the heating plate is affixed on by gluing incubates the disk back side, and the incubation disk uses
Pure aluminum material.
Further technical solution, the bottom of the reaction cup aperture are additionally provided with small sircle hole, and the temperature sensor is consolidated
It is scheduled in the small sircle hole for incubating the disk back side；The outside of the reaction cup aperture is Openworks shape.
Further technical solution, the motor that moves forward and backward is lead screw motor.
Further technical solution, the pushing meanss include the linear guide and sliding block, and the sliding block is located at straight line
On guide rail, the nut of the sliding block and lead screw motor is fixedly linked, and the sliding block and magnet frame are fixedly linked.
Further technical solution, the magnet frame is in sector.
Further technical solution, the Magneto separate stent are equipped with lifter and lifting motor.
Further technical solution, the last position of the magnet frame is low level magnet fixed block, and the low level magnet is consolidated
Fixed magnet in the block acts on the bottom of reaction cup.
The present invention the course of work be：The position that disk goes to magnetic separating device is incubated, lead screw motor rotates, the spiral shell on screw
Cap travels forward accordingly, and nut and sliding block are fixed together, and sliding block and magnet frame are fixed together, so as to drive magnet frame to
Preceding movement, when reaction cup goes to Magneto separate position, magnet sticks the side of reaction cup close at bottom, carries out Magneto separate, magnetic point
Being moved backward from magnetic separating device after the completion makes magnet leave reaction cup, incubates disk and rotates a position, so repeats above-mentioned dynamic
Make.Carry out drawing liquid after the completion of Magneto separate, magnet is attached in the bottom sides of reaction cup again during drawing liquid, and disk is incubated after drawing liquid and is turned
Last low level in magnet frame is moved, low level magnet is in the reaction cup after the completion of Magneto separate in last magnet fixed block
Magnetic bead move reaction cup bottommost to.
Advantageous effect
Compared with prior art, the present invention has following remarkable advantage：
1st, under incubation disk of the invention equipped with conducting slip ring device, the line of heating plate and temperature sensor is to be connected on conductive cunning
On ring, effectively solve the problems, such as that rotating disc type causes circuit to wind, and save space so that heating plate can be pasted directly by gluing
In incubating the disk back side, quick heating is realized.
2nd, the present invention controls temperature by temperature sensor, and it is temperature constant state to keep incubating disk, is influenced very by extraneous factor
It is small so that measurement data is more accurate.
3rd, incubation disk of the invention is pure aluminum material, and thermal conductivity is good, can realize quick heating.
4th, rotary tray motor of the invention, which drives to incubate to spiral, goes to corresponding position, coordinates other operations, such as be loaded, be mixed
Even, Magneto separate.
5th, drip tray of the invention, which is set on, incubates below disk, and positioned at the underface of reaction cup aperture, when reaction cup occurs
During leakage situation, reagent can be effectively prevent to outflow, avoid the generation of safety accident problem.
6th, the outside of reaction cup aperture of the invention is Openworks shape, is conducive to coordinate Magneto separate operation.
7th, each magnet of the invention is fixed in magnet fixed block, there is spring assembly after magnet fixed block, in this way whenever
When magnet sticks reaction cup, all there are one cushioning effect, guarantee is not to run into very stiff and demandingly, and adjusting after bonding position can be with
Fit closely each magnet and reaction cup, Magneto separate effect is more preferable.
8th, the side that the magnet in the present invention acts on reaction cup can effectively prevent liquid pumping needle to be inserted into anti-close at bottom
Magnetic bead is taken away when answering bottom of a cup portion drawing liquid, effectively magnetic bead is avoided to be lost in.
9th, the present invention carries out drawing liquid after the completion of Magneto separate, and magnet is still attached in reaction cup during drawing liquid, magnet after drawing liquid
There are one low level magnet in last low level magnet fixed block on frame, and low level magnet is in the reaction cup after the completion of Magneto separate
Magnetic bead moves reaction cup bottommost to, and when sending to injection excimer when measuring chamber measures in this way, reaction is more abundant, avoids magnetic bead
On reaction wall of cup, it is impossible to fully reaction.
10th, magnet frame of the invention contributes to be bonded circular incubation disk in sector, improves Magneto separate effect.
11st, the present invention, which integrates, incubates function, Magneto separate function, and temperature range, the magnetic separation time is accurately adjustable, the device
Performance is stablized, easy to operate.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the sectional view that device is incubated in the present invention；
Fig. 3 is the back view that disk is incubated in the present invention；
Fig. 4 is the enlarged drawing of the magnet frame of the present invention；
Fig. 5 is the enlarged drawing of the pushing meanss of the present invention；
Figure label explanation：1st, disk is incubated, 2, conducting slip ring, 3, rotary tray motor, 4, heating plate, 5, temperature sensor, 6,
Stent, 7, drip tray, 8, reaction cup aperture, 9, move forward and backward motor, 10, pushing meanss, 10-1, the linear guide, 10-2, sliding block,
11st, magnet frame, 12, magnet, 13, magnet fixed block, 14, Magneto separate stent, 15, pedestal, 16, spring assembly, 17, low level magnet
Fixed block, 18, magnetic receiver, 19, nut.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
Embodiment
As shown in Fig. 1 to 5, a kind of incubation magnetic separating device applied to chemical luminescent detecting, including incubating device and magnetic
Separator；
The incubation device includes incubating device, including incubating disk 1, conducting slip ring 2, rotary tray motor 3, heating plate 4, temperature
Sensor 5, stent 6 are spent, the incubation disk 1 is set on stent 6, and the back side of the incubation disk 1 is equipped with heating plate 4 and temperature
Sensor 5；The conducting slip ring 2 is set on the center for incubating disk, and the conducting wire of heating plate 4 and temperature sensor 5, which is wrapped in, leads
On electric slip ring 2；The rotation axis of the rotary tray motor 3 is connected with the center for incubating disk 1；It is set on the round edge of the incubation disk 1
There are several reaction cup aperture 8；
The magnetic separating device is fixed including moving forward and backward motor 9, pushing meanss 10, magnet frame 11, magnet 12, magnet
Block 13, Magneto separate stent 14, pedestal 15, spring assembly 16, the magnet frame 11 is by pushing meanss 10 and moves forward and backward electricity
Machine 9 is connected, and magnet frame 11 is equipped with several magnetic receivers 18, and 12 fixed block of magnet is set in magnetic receiver 18, the magnetic
Iron 12 is set in magnet fixed block 13 side for acting on reaction cup simultaneously close at bottom, and described moves forward and backward motor 9, pushes away
Dynamic device 10 and magnet frame 11 are set on Magneto separate stent 14, and the Magneto separate stent 14 is set on pedestal 15, described
Spring assembly 16 is set on inside magnetic receiver 18, and behind magnet fixed block 13；
Magnet 12 of the magnet frame 11 on the side for incubating disk 1, magnet frame 11 corresponds to anti-in reaction cup aperture 8
Answer the bottom sides of cup.
It incubates device and further includes drip tray 7, the drip tray 7, which is located at, to be incubated below disk 1, and positioned at reaction cup aperture 8
Underface.The heating plate 4 is affixed on by gluing incubates 1 back side of disk, and the incubation disk 1 uses pure aluminum material.It is described
The bottom of reaction cup aperture 8 be additionally provided with small sircle hole, the temperature sensor 5 is fixed in the small sircle hole for incubating the disk back side.Institute
The outside of reaction cup aperture 8 stated is Openworks shape.
The motor 9 that moves forward and backward is lead screw motor.The pushing meanss 10 include the linear guide 10-1 and sliding block
10-2, the sliding block 10-2 are located on the linear guide 10-1,19 stationary phase of nut of the sliding block 10-2 and lead screw motor
Even, the sliding block 10-2 and magnet frame 11 are fixedly linked.The magnet frame 11 is in sector.On the Magneto separate stent 14
Equipped with lifter and lifting motor.The last position of the magnet frame 11 is low level magnet fixed block 17, and the low level magnet is consolidated
Determine the bottom that the magnet in block 17 acts on reaction cup.
Claims (9)
1. a kind of incubation magnetic separating device applied to chemical luminescent detecting, which is characterized in that including incubating device and Magneto separate
Device；
The incubation device includes incubating disk, conducting slip ring, rotary tray motor, heating plate, temperature sensor, stent, described
It incubates disk to be set on stent, the back side of the incubation disk is equipped with heating plate and temperature sensor；The conducting slip ring is set on
The conducting wire of the center of incubation disk, heating plate and temperature sensor is wrapped on conducting slip ring；The rotation of the rotary tray motor
Axis is connected with the center for incubating disk；The round edge of the incubation disk is equipped with several reaction cup aperture；
The magnetic separating device includes moving forward and backward motor, pushing meanss, magnet frame, magnet, magnet fixed block, Magneto separate branch
Frame, pedestal, spring assembly, the magnet frame are connected by pushing meanss with moving forward and backward motor, and magnet frame is equipped with several
Magnetic receiver, the magnet fixed block are set in magnetic receiver, and the magnet is set in magnet fixed block and acts on reaction simultaneously
Close at bottom, move forward and backward motor, pushing meanss and the magnet frame are set on Magneto separate stent, described for the side of cup
Magneto separate branch be set up on pedestal, the spring assembly is set on inside magnetic receiver, and behind the magnet fixed block；
The side that magnet of the magnet frame on the side for incubating disk, magnet frame corresponds to the reaction cup in reaction cup aperture connects
At nearly bottom.
2. incubation magnetic separating device according to claim 1, which is characterized in that the incubation device further includes water receiving
Disk, the drip tray, which is located at, to be incubated below disk, and positioned at the underface of reaction cup aperture.
3. incubation magnetic separating device according to claim 1, which is characterized in that the heating plate is affixed on temperature by gluing
The disk back side is educated, the incubation disk uses pure aluminum material.
4. incubation magnetic separating device according to claim 1, which is characterized in that the bottom of the reaction cup aperture is additionally provided with
Small sircle hole, the temperature sensor are fixed in the small sircle hole for incubating the disk back side；The outside of the reaction cup aperture is hollow out
Shape.
5. incubation magnetic separating device according to claim 1, which is characterized in that the motor that moves forward and backward is screw electricity
Machine.
6. incubation magnetic separating device according to claim 5, which is characterized in that the pushing meanss include the linear guide
And sliding block, the sliding block are located in the linear guide, the nut of the sliding block and lead screw motor is fixedly linked, the sliding block
It is fixedly linked with magnet frame.
7. incubation magnetic separating device according to claim 1, which is characterized in that the magnet frame is in sector.
8. incubation magnetic separating device according to claim 1, which is characterized in that the Magneto separate stent is equipped with lifting
Device and lifting motor.
9. incubation magnetic separating device according to claim 1, which is characterized in that the last position of the magnet frame is low level magnetic
Ferropexy block, the low level magnet fix the bottom that magnet in the block acts on reaction cup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610102336.8A CN105758848B (en) | 2016-02-24 | 2016-02-24 | A kind of incubation magnetic separating device applied to chemical luminescent detecting |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610102336.8A CN105758848B (en) | 2016-02-24 | 2016-02-24 | A kind of incubation magnetic separating device applied to chemical luminescent detecting |
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| CN105758848A CN105758848A (en) | 2016-07-13 |
| CN105758848B true CN105758848B (en) | 2018-06-19 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106093016B (en) * | 2016-08-26 | 2018-10-30 | 深圳市库贝尔生物科技股份有限公司 | A kind of chemical luminescent detecting method |
| CN110153121A (en) * | 2019-06-21 | 2019-08-23 | 苏州长光华医生物医学工程有限公司 | It is a kind of for cleaning the magnetic particle adsorbent equipment and its cleaning equipment of reaction cup |
| CN110672835A (en) * | 2019-09-26 | 2020-01-10 | 合肥运涛光电科技有限公司 | Magnetic separation mechanism for chemiluminescence immunoassay system |
| CN111766232A (en) * | 2020-06-29 | 2020-10-13 | 苏州长光华医生物医学工程有限公司 | Inner and outer ring incubation disc device with auxiliary sample adding position and incubation method |
| WO2022237180A1 (en) * | 2021-05-13 | 2022-11-17 | 安图实验仪器(郑州)有限公司 | Magnetic attraction incubation mechanism of automatic molecular diagnostic instrument |
| CN116328945B (en) * | 2023-05-30 | 2023-08-08 | 天津喜诺生物医药有限公司 | Magnetic separation and warm bath device |
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| ATE369915T1 (en) * | 1998-05-01 | 2007-09-15 | Gen Probe Inc | INCUBATOR FOR AUTOMATIC ANALYZER |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101221192A (en) * | 2007-12-26 | 2008-07-16 | 冶金自动化研究设计院 | Full-automatic control system used for chemiluminescence immunity analysis |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN104324921A (en) * | 2014-08-29 | 2015-02-04 | 南京诺尔曼生物技术有限公司 | Tubular chemical luminescence immunity magnetic separation and cleaning device |
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Address after: No.197, Yaogu Avenue, Jiangbei new district, Nanjing City, Jiangsu Province Patentee after: Nanjing Norman Biotechnology Co.,Ltd. Address before: 210031, E building, building 10, Spark Road, No. 4, Spark Road, hi tech Zone, Jiangsu, Nanjing Patentee before: NANJING NORMAN BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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