CN105748778A

CN105748778A - Handheld pill and preparation method thereof

Info

Publication number: CN105748778A
Application number: CN201610324655.3A
Authority: CN
Inventors: 刘茂胜; 刘德福
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-17
Filing date: 2016-05-17
Publication date: 2016-07-13

Abstract

The invention relates to a handheld pill and a preparation method thereof and belongs to the technical field of traditional Chinese medicine pills. The handheld pill comprises the following components in parts by weight: 5-6 parts of speranskia tuberculata, 8-10 parts of Chinese red pepper, 4-5 parts of rhizoma imperatae, 4-5 parts of radix saposhnikoviae, 4-5 parts of semen strychni, 2-3 parts of parasitic loranthus, 4-5 parts of pawpaw, 2-3 parts of radix angelicae pubescentis, 2-3 parts of angelica sinensis, 2-3 parts of ligusticum wallichii, 1-2 parts of corn cervi pantotrichum, 1-2 parts of musk, 3-4 parts of homalomena occulta, 2-3 parts of cortex illicii, 5-6 parts of folium artemisiae argyi, 10-15 parts of ferrosic oxide, 5-6 parts of safflower carthamus, 3-4 parts of radix clematidis, 2-3 parts of eucommia ulmoides, 3-8 parts of frankincense, 20-35 parts of vinegar and 2-8 parts of myrrh. The handheld pill provided by the invention is better in curative effect on puerperium fever and rheumatic arthritis.

Description

One holds pill and preparation method thereof

Technical field

The present invention relates to one and hold pill and preparation method thereof, belong to medicine pill technical field.

Background technology

Puerperal fever, be also referred to as " puerperal exposure to wind, the moon consumptive disease, the moon man's consumptive disease, the moon traitor sick, slander by the moon, dry otopathy " etc., be women in childbirth period, because muscles and bones space between skin and muscles is opened greatly, physical weakness, a kind of disease that inside and outside inanition not preventing wind-cold pathogen invades and causes.First, the preparation for treating effect of existing treatment puerperal fever is undesirable.Secondly, existing at present for therapeutic modality many employings oral medicinal liquor of puerperal fever, pill, the mode of oral formulations brings more inconvenience to patient, reduces the enthusiasm of patient treatment.

Summary of the invention

The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, it is provided that one holds pill and preparation method thereof, and this holds pill has good curative effect for puerperal fever, and topical administration toxic and side effects is low, instant effect.

The technical solution adopted for the present invention to solve the technical problems is: this holds pill, is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 ~ 6 parts, 8 ~ 10 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4 ~ 5 parts, Radix Saposhnikoviae 4 ~ 5 parts, Semen Strychni 4 ~ 5 parts, Herba Taxilli 2 ~ 3 parts, Fructus Chaenomelis 4 ~ 5 parts, Radix Angelicae Pubescentis 2 ~ 3 parts, Radix Angelicae Sinensis 2 ~ 3 parts, Rhizoma Chuanxiong 2 ~ 3 parts, 1 ~ 2 part of Cornu Cervi Pantotrichum, 1 ~ 2 part of Moschus, Rhizoma Homalomenae 3 ~ 4 parts, Cortex Illicii 2 ~ 4 parts, Folium Artemisiae Argyi 5 ~ 6 parts, pulvis ferri (ferrosic oxide) 10 ~ 15 parts, 5 ~ 6 parts of Flos Carthami, Radix Clematidis 3 ~ 4 parts, the Cortex Eucommiae 2 ~ 3 parts, Olibanum 3 ~ 8 parts, vinegar 20 ~ 35 parts, Myrrha 2 ~ 8 parts.

This holds pill, it is characterized in that, be made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 ~ 5.5 parts, 9 ~ 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4.5 ~ 5 parts, Radix Saposhnikoviae 4.5 ~ 5 parts, Semen Strychni 4 ~ 4.5 parts, Herba Taxilli 2.5 ~ 3 parts, Fructus Chaenomelis 4 ~ 4.5 parts, Radix Angelicae Pubescentis 2.5 ~ 3 parts, Radix Angelicae Sinensis 2 ~ 2.5 parts, Rhizoma Chuanxiong 2.5 ~ 3 parts, 1.5 ~ 2 parts of Cornu Cervi Pantotrichum, 1.5 ~ 2 parts of Moschus, Rhizoma Homalomenae 3 ~ 3.5 parts, Cortex Illicii 2 ~ 3.5 parts, Folium Artemisiae Argyi 5.5 ~ 6 parts, pulvis ferri (ferrosic oxide) 12 ~ 13 parts, 5 ~ 5.5 parts of Flos Carthami, Radix Clematidis 3.5 ~ 4 parts, the Cortex Eucommiae 2 ~ 2.5 parts, Olibanum 4 ~ 5 parts, vinegar 20 ~ 30 parts, Myrrha 2 ~ 3 parts.

This holds pill, it is characterized in that, be made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 parts, 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4.5 parts, Semen Strychni 4.3 parts, Herba Taxilli 2.8 parts, Fructus Chaenomelis 4.2 parts, Radix Angelicae Pubescentis 2.8 parts, Radix Angelicae Sinensis 2.5 parts, Rhizoma Chuanxiong 2.8 parts, 1.8 parts of Cornu Cervi Pantotrichum, 1.8 parts of Moschus, Rhizoma Homalomenae 3.3 parts, Cortex Illicii 3.3 parts, Folium Artemisiae Argyi 5.8 parts, pulvis ferri (ferrosic oxide) 12.5 parts, 5.3 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 23 ~ 25 parts, Myrrha 2.5 parts.

Described a kind of manufacture method holding pill, it is characterised in that adopt following steps:

1) raw material Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum and Myrrha are weighed by weight ratio, put into pulverizer after mix homogeneously to pulverize, 300 ~ 700 mesh sieves are crossed after pulverizing, mix homogeneously, it is thus achieved that medicated powder；

2) medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 20 ~ 60 ° of C, and dried every ball weighs 5 ~ 30 grams, to obtain final product.

For crossing 500 mesh sieves after pulverizing in step 1).

Step 2) in dry through 35 ~ 45 ° of C, dried every ball weighs 9 ~ 15 grams.

Step 2) carry out on machine for making water-bindered pills.

Applicant is as follows for the explanation of inventive formulation:

Herba speranskiae tuberculatae, pungent, bitter, temperature.Return liver, kidney channel.Function cures mainly: expelling wind and removing dampness, pain relieving of detoxifying.For rheumatic arthritis；Sore swollen toxin, snake bite and insect sting are controlled in external.

Pericarpium Zanthoxyli, nature and flavor are pungent, temperature.Return spleen, stomach, kidney channel.This product is the dry mature skin of rutaceae Zanthoxylum schinifolium and seed is used as medicine.Function cures mainly: warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, solves fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomit, oh, cough with dyspnea, anemofrigid-damp arthralgia, have loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.

Rhizoma Imperatae, sweet, cold.Enter lung, stomach, small intestine meridian.For the dry rhizome of cogon Herba Imperatae, in elongated cylindrical.Function cures mainly: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Housewife's man month, promoting blood circulation drenched drop through irregular.Only married woman's metrostaxis.

Radix Saposhnikoviae, property is pungent, sweet, tepor.Return lung, bladder, liver, spleen channel.Function is expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.For feeling rheumatism or rheumatic arthralgia.

Semen Strychni, nature and flavor are bitter, temperature.Return liver, spleen channel.Function cures mainly: removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain；Poliomyelitis sequela, rheumatoid arthritis.

Herba Taxilli, nature and flavor bitter, sweet, flat.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement；Hypertension.

Fructus Chaenomelis, nature and flavor acid, temperature.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, waist knee joint acid weight pain, convulsion of vomiting and diarrhoea, beriberi edema.

Radix Angelicae Pubescentis, property is pungent, bitter, tepor.Function is expelling wind and dampness, pain relieving, for rheumatic arthralgia, soreness of waist and knee joint, YIN-cold headache, facial paralysis mouth fish sticking its mouth out of the water.

Radix Angelicae Sinensis, property sweet, acrid, warm.Return liver, the heart, spleen channel.Function is replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For rheumatic arthralgia, injury from falling down, blood deficiency and yellow complexion, dizziness cardiopalmus, asthenia cold abdominalgia, dryness of the intestine constipation.

Rhizoma Chuanxiong, nature and flavor are pungent, temperature.Return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.

Cornu Cervi Pantotrichum, property sweet-salty, temperature.Enter liver, kidney channel.Function cures mainly kidney-Yang invigorating, fills blood, benefit marrow, bone and muscle strengthening.Controlling asthenia weakness and emaciation, spirit is tired weary, dizziness, deaf, and order is dark, soreness of waist and knee joint, sexual impotence, spermatorrhea；Deficiency-cold of uterus, metrorrhagia, leukorrhagia.

Moschus, pungent, temperature.GUIXIN, spleen channel.Function cures mainly: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea, abdominal mass, stillborn fetus of having difficult labour, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain falls and flutters the pain of injury, and arthralgia pain is numb.

Rhizoma Homalomenae, nature and flavor are pungent, temperature.Mild toxicity.Enter liver；Kidney；Stomach was excavated through spring, season in autumn two, cleaned, and removes crust, dries.Dry rhizome for Araeceae flat silk taro platymiscium Rhizoma Homalomenae.There is the effects such as wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, detumescence.Cure mainly rheumatic arthralgia, podomere acid is educated, muscles and bones flaccidity is soft, traumatic injury, stomachache, carbuncle skin ulcer are swollen.

Cortex Illicii, nature and flavor: pungent；Puckery；Warm in nature；Gui Jing:Spleen；Stomach warp.Effect: expelling wind and removing dampness；Promoting the circulation of QI to relieve pain, expelling wind and removing dampness, cure mainly the disease such as rheumatic arthralgia, lumbar muscle strain.

Folium Artemisiae Argyi, nature and flavor are pungent, bitter, temperature；Slightly poisonous.Return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage；External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.

Pulvis ferri (ferrosic oxide), also referred to as pulvis ferri (ferrosic oxide), is mainly composed of ferroso-ferric oxide, the thin pulvis ferri (ferrosic oxide) hit down because of outer oxide during for forging iron, or side-product pulvis ferri (ferrosic oxide) during ironworks's wrought iron.Pungent, flat, nontoxic.Function cures mainly: checking hyperfunction of the liver for relieving convulsion.Control demented, febrile delirium, cardiopalmus, easily frightened susceptible to get angry, sore swollen toxin；Solve toxic swelling, sore；Enrich blood；Febrile delirium；Palpitation and being susceptible to fright；Rheumatic arthralgia；Also there is the effect of promoting blood circulation to disperse blood clots and relieves pain, articulation is bad, sprain pain and have good therapeutic effect.

Flos Carthami, nature and flavor are pungent, temperature.GUIXIN, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.

Radix Clematidis, nature and flavor: pungent, salty, temperature.Gui Jing: return bladder warp.Function cures mainly: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, muscle arteries and veins contracture, joint stuffiness, bone is choked with sobs larynx.

The Cortex Eucommiae, sweet, temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement；Hypertension.

Olibanum, property is worked hard, temperature.Enter the heart, liver, spleen channel.Function is regulating qi and activating blood, and analgesic therapy chases after poison.Cure mainly: coagulation of QI-blood, trusted subordinate's pain, ulcerative carbuncle toxic swelling, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Myrrha, property is bitter, flat.GUIXIN, liver, spleen channel.Function is for dissipating blood and relieving pain, detumescence and promoting granulation.For ulcer sore pain, trusted subordinate, all pains of muscles and bones, traumatic blood stasis, external can expelling pus and promoting granulation.Promoting blood circulation to remove blood stasis eases pain.External has convergence and antiinflammation.In addition various skin tinea bacterium there is inhibitory action in various degree.And tubercule bacillus can be suppressed.

Vinegar, bitter, temperature.Enter liver, stomach warp.Function cures mainly: dissipating blood stasis, hemostasis, removing toxic substances, parasite killing.Controlling puerperal blood faints, mass beside the umbilicus lump in the abdomen, jaundice, yellowish perspiration, spit blood, epistaxis, hematochezia of defecating, pudendal pruritus, carbuncle skin ulcer swells, and solves flesh of fish dish poison.Chemical composition includes: extractum matter, ash, volatile acid, fixed acid, reducing sugar, and concrete material has higher alcohols, 3-Hydroxybutanone, dihydroxy acetone, butyl alcohol, acetaldehyde, formaldehyde, acetal, acetic acid (content 3 ~ 5%), succinic acid, oxalic acid and sorbose.

Although the applicant expects that puerperal fever be due to women in puerperal period muscles and bones space between skin and muscles with the door open, deficient qi and blood, inside and outside inanition, careless wind-cold damp pathogen invade, theory of Chinese medical science thinks what " cold-evil is to the marrow " caused.Pericarpium Zanthoxyli, Flos Carthami, Rhizoma Homalomenae, Olibanum, Myrrha coupling have the effect of blood circulation promoting and blood stasis dispelling, dredging the meridian, profit the five internal organs, except six internal organs are cold, having the effect of Synergistic after coupling, wherein applicant with the addition of 8 ~ 10 parts of Pericarpium Zanthoxyli in formula, and Pericarpium Zanthoxyli can remove old blood, solve disease stomachache more than puerperal, perspire, loosing the interspaces of skin and muscles, promoting blood circulation.Cornu Cervi Pantotrichum, Radix Angelicae Sinensis, pulvis ferri (ferrosic oxide), Folium Artemisiae Argyi, Rhizoma Imperatae coupling have enrich blood foster the spirit of nobility, effect of blood stasis dispelling, toxic swelling of dispelling, it is found by the applicant that wherein pulvis ferri (ferrosic oxide) consumption to cross drug effect at least not good, optimum amount is pulvis ferri (ferrosic oxide) 10 ~ 15 parts, it is preferred that pulvis ferri (ferrosic oxide) 12 ~ 13 parts.

Applicant in formula using vinegar as main binder, vinegar can remove the toxicity of all medicines in formula, the drug effect making pill strengthens, vinegar can not replace with water, Mel, Colophonium, oil or other binding agents, in step 2) water more than 90% in vinegar is dry in the dry run of pill scatters and disappears, moisture content is extremely low, and the multiple organic principle in vinegar is stayed this and is held in pill, can promote that this effective ingredient holding in pill volatilizees, there is the effect promoting that drug effect absorbs, and Olibanum and Myrrha also have the effect of pill binding agent wherein, after pulverizing, Powdered Olibanum and Myrrha are in step 2) softening in dry run, whole pill is bonded as binding agent, prevent this from holding pill dehydration cracking in long-term storage process.

Applicant finds after deliberation when adopting 5 ~ 6 parts of lopseeds, 8 ~ 10 parts, Chinese prickly ash, 4 ~ 5 parts of lalang grass rhizome grass, windproof 4 ~ 5 parts, 4 ~ 5 parts of vomiting nuts, 2 ~ 3 parts of parasitic loranthus, 4 ~ 5 parts of pawpaws, 2 ~ 3 parts of levisticums, 2 ~ 3 parts of Radix Angelicae Sinensis, 2 ~ 3 parts of Ligusticum wallichiis, 1 ~ 2 part, pilose antler, 1 ~ 2 part, Moschus, 3 ~ 4 parts of rhizoma homalonemaes, 2 ~ 4 parts of anisetree barks, 5 ~ 6 parts of tarragons, iron falls 10 ~ 15 parts, 5 ~ 6 parts, safflower, 3 ~ 4 parts, the root of Chinese clematis, 2 ~ 3 parts of the barks of eucommia, 3 ~ 8 parts of frankincenses, 20 ~ 35 parts of vinegar, when consumption proportion that myrrh is 2 ~ 8 parts, can reach high value .nullIn order to improve curative effect for puerperal fever with the efficient of rheumatic arthritis, Applicant is found by clinical research, Work as employing:Herba speranskiae tuberculatae 5 ~ 5.5 parts, 9 ~ 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4.5 ~ 5 parts, Radix Saposhnikoviae 4.5 ~ 5 parts, Semen Strychni 4 ~ 4.5 parts, Herba Taxilli 2.5 ~ 3 parts, Fructus Chaenomelis 4 ~ 4.5 parts, Radix Angelicae Pubescentis 2.5 ~ 3 parts, Radix Angelicae Sinensis 2 ~ 2.5 parts, Rhizoma Chuanxiong 2.5 ~ 3 parts, 1.5 ~ 2 parts of Cornu Cervi Pantotrichum, 1.5 ~ 2 parts of Moschus, Rhizoma Homalomenae 3 ~ 3.5 parts, Cortex Illicii 2 ~ 3.5 parts, Folium Artemisiae Argyi 5.5 ~ 6 parts, Pulvis ferri (ferrosic oxide) 12 ~ 13 parts, 5 ~ 5.5 parts of Flos Carthami, Radix Clematidis 3.5 ~ 4 parts, The Cortex Eucommiae 2 ~ 2.5 parts, Olibanum 4 ~ 5 parts, Vinegar 20 ~ 30 parts, During the consumption proportion that Myrrha is 2 ~ 3 parts, The effective percentage change of rheumatic arthritis and gout is little, But the effective percentage of puerperal fever obtains and improves further.Final applicant confirms after deliberation, when according to consumption proportion being:Herba speranskiae tuberculatae 5 parts, 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4.5 parts, Semen Strychni 4.3 parts, Herba Taxilli 2.8 parts, Fructus Chaenomelis 4.2 parts, Radix Angelicae Pubescentis 2.8 parts, Radix Angelicae Sinensis 2.5 parts, Rhizoma Chuanxiong 2.8 parts, 1.8 parts of Cornu Cervi Pantotrichum, 1.8 parts of Moschus, Rhizoma Homalomenae 3.3 parts, Cortex Illicii 3.3 parts, Folium Artemisiae Argyi 5.8 parts, pulvis ferri (ferrosic oxide) 12.5 parts, 5.3 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 23 ~ 25 parts, Myrrha 2.5 parts configures, the holding pill and all can reach optimum curative effect in treatment puerperal fever and rheumatic arthritis of gained, and effective percentage compares other proportionings and has prominent raising.

Applicant is as follows for the explanation of preparation method of the present invention: applicant will pulverize by Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum, Myrrha, sieve in step 1), it is thus achieved that medicated powder；Crossing 300 ~ 700 mesh sieves after pulverizing can by pulverizing medicinal materials to micron, it is easy to the volatilization of the effective ingredient in medical material, is absorbed by the body, when the order number sieved is less than 300 order, herb in granule form is excessive, affects drug effect volatilization, when having served as grit number more than 600 order, herb in granule form is too small, patient is when holding use, after hand is perspired, owing to herb in granule form is too small, pill surface viscosity is bigger, easily pollute patient hand, and the cost of crushing process can be raised.Crossing 500 mesh sieves after preferably pulverizing, the granular size of this order number gained medicated powder is moderate, and this property of medicine holding pill of final gained is volatilized effective, and not easily pollutes patient hand, and pulverizes advantage of lower cost.Applicant's design procedure 2) in baking temperature be 20 ~ 60 ° of C, when baking temperature is lower than 20 ° of C, this holds pill, and dry the used time is long, be difficult to parch；When baking temperature is higher than 60 ° of C, this effective ingredient held in pill is volatilized in a large number by high temperature, affects drug effect.Preferred baking temperature is 20 ~ 45 ° of C, and this temperature range both can guarantee that higher drying efficiency, can reduce again this as far as possible and hold the volatilization of effective ingredient in pill, it is preferred that dries and carries out on 20 ~ 60 ° of C low-temperature air-drying machines.Step 2) weight that defines pill is 5 ~ 30 grams, it is consider that due to applicant this is held pill employing and holds the administration of medicine method under study for action, and there is restriction scope in the area of staff, when pill quality is too small, pill surface area is too small, reduce with hand skin contact area, be unfavorable for that drug effect absorbs；When pill quality is excessive, pill volume is excessive, and staff is difficult to stable gripping, and when patient holds pill motion, this is held pill and easily slips from patient's hands, drops.Preferably, dried every ball weighs 9 ~ 15 grams.Step 2) to adopt vinegar be binding agent and step 1) medicated powder is mixed into ball, it is preferable that step 2) carry out on machine for making water-bindered pills, it is preferred to use fabricating quality is carry out on the stainless steel water pill of more than 5 grams boluss；It addition, step 2) watered pill home built method can also be adopted to dry through molding, molding, capping, 20 ~ 60 ° of C, it is thus achieved that and this holds pill, and molding is raw materials used for step 1) medicated powder and vinegar, and capping part used by capping is step 1) medicated powder.

Compared with prior art, the one of the present invention is held pill and preparation method thereof and is had the beneficial effect that

1, this holds pill has good curative effect for puerperal fever.This is held pill employing and holds the treatment of medicine method, medicine is permeated by hand skin and absorbs, enter body, with the through sick institute of blood operation, and play pharmacological effect preventable disease and cure the disease, or medicine, by constantly stimulating skin or the acupuncture point, the centre of the palm holding medicine position, regulates the function of the nerve of patient's body, body fluid, tissue, organ indirectly, all diseases caused for puerperal fever have good curative effect.

2, this holds pill Bi condition all good curative effect.Bi condition rheumatism numbness is to wait exopathogen invasion, impatency meridians joint owing to wind and cold is damp and hot, and QI-blood circulation is smooth, main clinical manifestation is general joint be migrans red, swell, weigh, pain, often refer to rheumatic arthritis.This holds pill energy removing damp and stopping pain, and rheumatic numbness has good curative effect.Use this to hold pill and can effectively repair the damage of connective tissue, accelerate articular cartilage and ligament repair speed, thus alleviating the effect of arthropathy that rheumatism causes, numbness, pain.

3, this holds pill has good therapeutic effect for gout.Applicant find under study for action this hold pill can tonification kidney, nurse one's health the five internal organs, good remission effect is respectively provided with for primary gout and secondary gout.

4, this holds pill has good therapeutic effect for gout, habitual chilblain.Applicant finds that the gripping pill of the present invention can promoting the circulation of blood dredging collateral in clinical studies, habitual chilblain there is good curative effect, particularly frostbite of hand cure rate reaches 100%, chilblain effective percentage for face, foot reaches 100%, cure rate can reach more than 90%, and after healing, Second Year chilblain in winter no longer recurs.

Detailed description of the invention

Embodiment 1 ~ 5 is a kind of detailed description of the invention holding pill and preparation method thereof of the present invention, and wherein embodiment 1 is most preferred embodiment.In embodiment, machine for making water-bindered pills used is the HBZ-202 type machine for making water-bindered pills that the vast rich dynamo-electric company limited of Rui'an City produces.

Embodiment 1

The present embodiment formula is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 parts, 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4.5 parts, Semen Strychni 4.3 parts, Herba Taxilli 2.8 parts, Fructus Chaenomelis 4.2 parts, Radix Angelicae Pubescentis 2.8 parts, Radix Angelicae Sinensis 2.5 parts, Rhizoma Chuanxiong 2.8 parts, 1.8 parts of Cornu Cervi Pantotrichum, 1.8 parts of Moschus, Rhizoma Homalomenae 3.3 parts, Cortex Illicii 3.3 parts, Folium Artemisiae Argyi 5.8 parts, pulvis ferri (ferrosic oxide) 12.5 parts, 5.3 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 23 parts, Myrrha 2.5 parts.

The preparation method of the present embodiment is:

1) raw material Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum, Myrrha are weighed by weight ratio, put into pulverizer after mix homogeneously to pulverize, 500 mesh sieves are crossed after pulverizing, mix homogeneously, it is thus achieved that medicated powder；

2) on machine for making water-bindered pills, medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 35 ~ 45 ° of C, and dried every ball weighs 9 grams, to obtain final product.

Embodiment 2

The present embodiment formula is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5.5 parts, 9 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4.5 parts, Semen Strychni .5 part, Herba Taxilli 2.5 parts, Fructus Chaenomelis 4.5 parts, Radix Angelicae Pubescentis 2.5 parts, Radix Angelicae Sinensis 2.5 parts, Rhizoma Chuanxiong 2.5 parts, 2 parts of Cornu Cervi Pantotrichum, 1.5 parts of Moschus, Rhizoma Homalomenae 3.5 parts, Cortex Illicii 2 parts, Folium Artemisiae Argyi 6 parts, pulvis ferri (ferrosic oxide) 12 parts, 5.5 parts of Flos Carthami, Radix Clematidis 3.5 parts, the Cortex Eucommiae 2.5 parts, Olibanum 4 parts, vinegar 25 parts, Myrrha 2 parts.

The preparation method of the present embodiment is:

2) on machine for making water-bindered pills, medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 20 ~ 30 ° of C, and dried every ball weighs 10 grams, to obtain final product.

Embodiment 3

The present embodiment formula is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 parts, 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4.5 parts, Radix Saposhnikoviae 5 parts, Semen Strychni 4 parts, Herba Taxilli 3 parts, Fructus Chaenomelis 4 parts, Radix Angelicae Pubescentis 3 parts, Radix Angelicae Sinensis 2 parts, Rhizoma Chuanxiong 3 parts, 1.5 parts of Cornu Cervi Pantotrichum, 2 parts of Moschus, Rhizoma Homalomenae 3 parts, Cortex Illicii 3.5 parts, Folium Artemisiae Argyi 5.5 parts, pulvis ferri (ferrosic oxide) 13 parts, 5 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 20 parts, Myrrha 3 parts.

The preparation method of the present embodiment is:

1) raw material Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum, Myrrha are weighed by weight ratio, put into pulverizer after mix homogeneously to pulverize, 600 mesh sieves are crossed after pulverizing, mix homogeneously, it is thus achieved that medicated powder；

2) on machine for making water-bindered pills, medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 20 ~ 30 ° of C, and dried every ball weighs 15 grams, to obtain final product.

Embodiment 4

The present embodiment formula is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 6 parts, 8 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4 parts, Semen Strychni 5 parts, Herba Taxilli 2 parts, Fructus Chaenomelis 5 parts, Radix Angelicae Pubescentis 2 parts, Radix Angelicae Sinensis 3 parts, Rhizoma Chuanxiong 2 parts, 2 parts of Cornu Cervi Pantotrichum, 1 part of Moschus, Rhizoma Homalomenae 4 parts, Cortex Illicii 2 parts, Folium Artemisiae Argyi 6 parts, pulvis ferri (ferrosic oxide) 10 parts, 6 parts of Flos Carthami, Radix Clematidis 3 parts, the Cortex Eucommiae 3 parts, Olibanum 3 parts, vinegar 25 parts, Myrrha 2 parts.

The preparation method of the present embodiment is:

1) raw material Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum, Myrrha are weighed by weight ratio, put into pulverizer after mix homogeneously to pulverize, 300 mesh sieves are crossed after pulverizing, mix homogeneously, it is thus achieved that medicated powder；

2) on machine for making water-bindered pills, medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 30 ~ 40 ° of C, and dried every ball weighs 6 grams, to obtain final product.

Embodiment 5

The present embodiment formula is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 parts, 10 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4 parts, Radix Saposhnikoviae 5 parts, Semen Strychni 4 parts, Herba Taxilli 3 parts, Fructus Chaenomelis 4 parts, Radix Angelicae Pubescentis 3 parts, Radix Angelicae Sinensis 2 parts, Rhizoma Chuanxiong 3 parts, 1 part of Cornu Cervi Pantotrichum, 2 parts of Moschus, Rhizoma Homalomenae 3 parts, Cortex Illicii 4 parts, Folium Artemisiae Argyi 5 parts, pulvis ferri (ferrosic oxide) 15 parts, 5 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 20 parts, Myrrha 2 parts.

The preparation method of the present embodiment is:

1) raw material Herba speranskiae tuberculatae, Pericarpium Zanthoxyli, Rhizoma Imperatae, Radix Saposhnikoviae, Semen Strychni, Herba Taxilli, Fructus Chaenomelis, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cornu Cervi Pantotrichum, Moschus, Rhizoma Homalomenae, Cortex Illicii, Folium Artemisiae Argyi, pulvis ferri (ferrosic oxide), Flos Carthami, Radix Clematidis, the Cortex Eucommiae, Olibanum, Myrrha are weighed by weight ratio, put into pulverizer after mix homogeneously to pulverize, 400 mesh sieves are crossed after pulverizing, mix homogeneously, it is thus achieved that medicated powder；

2) adopting manual water pill manufacture method, medicated powder step 1) obtained rolls with vinegar and mixes, and makes pill, dries through 45 ~ 55 ° of C, and dried every ball weighs 20 grams, to obtain final product.

The clinical practice of the present invention is summarized as follows:

The one of the present invention holds pill using method: this is held pill and is held in the hand, first use two pieces, in every palm each grip one piece this hold pill, grip 1 ~ 10 hour every day.Preferred occupation mode is: grips this every day and holds pill 1 ~ 3 hour, and during gripping, patient carries out taking a walk or jogging, or carries out other sports, to promote the absorption of drug effect.Use every day after terminating, this is held pill and is placed on shady and cool dry place preservation.First use two pieces, every two pieces this hold pill and can use 5 ~ 7 days, within 30 days, be a course for the treatment of, use continuously between the adjacent course for the treatment of.. patient needs have a rest more, keeps sleep in more than 8 hours every day, avoids and catches a cold, avoid cold water and have a bath after motion perspiration.

Puerperal fever cardinal symptom: be afraid of cold from head to foot, aversion to wind, cold perspiration, arthralgia, meet cold reception wind pain and increase the weight of, get well clothing, serious patient wears cotton dress even hot day.Be afraid of cold, aversion to wind, arthralgia, additionally with numb, twitch, distending pain；Heavy from head to foot, unable, the soreness of waist, tired, pain, not endurance, some patients is with rheumatism and rheumatoid symptom；It is in a very depressed state, it is easy to cause depression of liver-QI, causes that QI and blood is not smooth；One or more of above symptom.

Rheumatic arthritis cardinal symptom: joint and myalgia, numbness, arthroncus, irregular heating, joint motion limited influence orthobiosis, one or more of above symptom.

Gout: pain Progressive symmetric erythrokeratodermia aggravates, and reaches peak at 12 hours, in tearing sample, lancinate sample or sting and bite sample, it is difficult to stands.Affected joints and surrounding tissue is red, swollen, hot, pain and function limitation, more than a couple of days or 2 weeks interior spontaneous remission；One or more of above symptom.

Habitual chilblain: the habitual chilblain of indication of the present invention belongs to chilblain, mainly for annual chilblain habituation outbreak cold season, it is difficult to the patient of radical cure.Local skin erythema repeatedly, tumidus infringement, severe patient may occur in which vesicle, ulcer, and the course of disease is slow, and weather turns warm rear spontaneous recovery, recurrence when winter and the early spring, temperature was low；One or more of above symptom, and the patient of chilblain recurrence in continuous more than 2 years occurs.

Curative effect judging standard: according to the improvement situation of above-mentioned symptom, is divided into recovery from illness, effective and invalid, fully recovers and is suffered from symptom in each symptom course for the treatment of by patient and all alleviate；Effective being suffered from symptom symptom partial rcsponse within the course for the treatment of by patient, partial symptoms does not improve；Invalid by patient suffered from symptom within the course for the treatment of without any improvement.As described above, total effective rate is whole cure rate and portion's obvious effective rate sum.Each embodiment randomly selects 200 cases and treats, and what sufferer used embodiment 1 ~ 5 respectively holds pill, and each case uses the pill of an embodiment until terminating the course for the treatment of, and midway is changed without medicine.

One, table 1 is statistics puerperal fever therapeutic effect after 3 courses for the treatment of.At 23 ~ 45 years old case age of table 1, sex is women.Statistical result is as shown in table 1:

A kind of curative effect statistics holding pill treatment puerperal fever of table 1 present invention

Two, table 2 is statistics rheumatic arthritis therapeutic effect, 30 ~ 55 years old case age of table 2 after 6 courses for the treatment of.Statistical result is as shown in table 1:

A kind of curative effect statistics holding pill treatment rheumatic arthritis of table 2 present invention

Three, table 3 is statistics gout treatment effect after 3 courses for the treatment of.Curative effect sorting technique, case are chosen, the mensuration of average cured time is with table 1 ~ 2.Healing standard: arthralgia stops, swelling disappears, and movable recovery is normal.Statistical result is as shown in table 3:

A kind of curative effect statistics holding pill treatment gout of table 3 present invention

Four, table 4 is the habitual treatment of perniosis effect of statistics after 1 course for the treatment of.

A kind of curative effect statistics holding the habitual chilblain of pill treatment of table 4 present invention

Being can be seen that by table 1 ~ 4, embodiment 1 ~ 5 is respectively provided with good curative effect for puerperal fever, rheumatic arthritis, gout and habitual chilblain.Embodiment 1 all reaches optimal value for the therapeutic effect of puerperal fever, rheumatic arthritis and chilblain, and the therapeutic effect of gout is relatively better, and therefore the embodiment 1 combined therapy effect in embodiment 1 ~ 5 is best.In table 1 ~ 4, the combined therapy effect of embodiment 2 ~ 3 is better than embodiment 4 ~ 5, it was demonstrated that preferred composition of raw materials in the present invention, not elective, and has practical significance.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims

1. hold pill for one kind, it is characterized in that, the raw material including following weight portion is made: Herba speranskiae tuberculatae 5 ~ 6 parts, 8 ~ 10 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4 ~ 5 parts, Radix Saposhnikoviae 4 ~ 5 parts, Semen Strychni 4 ~ 5 parts, Herba Taxilli 2 ~ 3 parts, Fructus Chaenomelis 4 ~ 5 parts, Radix Angelicae Pubescentis 2 ~ 3 parts, Radix Angelicae Sinensis 2 ~ 3 parts, Rhizoma Chuanxiong 2 ~ 3 parts, 1 ~ 2 part of Cornu Cervi Pantotrichum, 1 ~ 2 part of Moschus, Rhizoma Homalomenae 3 ~ 4 parts, Cortex Illicii 2 ~ 4 parts, Folium Artemisiae Argyi 5 ~ 6 parts, pulvis ferri (ferrosic oxide) 10 ~ 15 parts, 5 ~ 6 parts of Flos Carthami, Radix Clematidis 3 ~ 4 parts, the Cortex Eucommiae 2 ~ 3 parts, Olibanum 3 ~ 8 parts, vinegar 20 ~ 35 parts, Myrrha 2 ~ 8 parts.

2. one according to claim 1 holds pill, it is characterized in that, it is made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 ~ 5.5 parts, 9 ~ 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 4.5 ~ 5 parts, Radix Saposhnikoviae 4.5 ~ 5 parts, Semen Strychni 4 ~ 4.5 parts, Herba Taxilli 2.5 ~ 3 parts, Fructus Chaenomelis 4 ~ 4.5 parts, Radix Angelicae Pubescentis 2.5 ~ 3 parts, Radix Angelicae Sinensis 2 ~ 2.5 parts, Rhizoma Chuanxiong 2.5 ~ 3 parts, 1.5 ~ 2 parts of Cornu Cervi Pantotrichum, 1.5 ~ 2 parts of Moschus, Rhizoma Homalomenae 3 ~ 3.5 parts, Cortex Illicii 2 ~ 3.5 parts, Folium Artemisiae Argyi 5.5 ~ 6 parts, pulvis ferri (ferrosic oxide) 12 ~ 13 parts, 5 ~ 5.5 parts of Flos Carthami, Radix Clematidis 3.5 ~ 4 parts, the Cortex Eucommiae 2 ~ 2.5 parts, Olibanum 4 ~ 5 parts, vinegar 20 ~ 30 parts, Myrrha 2 ~ 3 parts.

3. one according to claim 1 holds pill, it is characterized in that, be made up of the raw material of following weight portion: Herba speranskiae tuberculatae 5 parts, 9.5 parts of Pericarpium Zanthoxyli, Rhizoma Imperatae 5 parts, Radix Saposhnikoviae 4.5 parts, Semen Strychni 4.3 parts, Herba Taxilli 2.8 parts, Fructus Chaenomelis 4.2 parts, Radix Angelicae Pubescentis 2.8 parts, Radix Angelicae Sinensis 2.5 parts, Rhizoma Chuanxiong 2.8 parts, 1.8 parts of Cornu Cervi Pantotrichum, 1.8 parts of Moschus, Rhizoma Homalomenae 3.3 parts, Cortex Illicii 3.3 parts, Folium Artemisiae Argyi 5.8 parts, pulvis ferri (ferrosic oxide) 12.5 parts, 5.3 parts of Flos Carthami, Radix Clematidis 4 parts, the Cortex Eucommiae 2 parts, Olibanum 5 parts, vinegar 23 ~ 25 parts, Myrrha 2.5 parts.

4. a kind of manufacture method holding pill described in any one of claim 1 ~ 3, it is characterised in that adopt following steps:

5. a kind of manufacture method holding pill according to claim 4, it is characterised in that: for crossing 500 mesh sieves after pulverizing in step 1).

6. a kind of manufacture method holding pill according to claim 4, it is characterised in that: step 2) in dry through 35 ~ 45 ° of C, dried every ball weighs 9 ~ 15 grams.

7. a kind of manufacture method holding pill according to claim 4, it is characterised in that: step 2) carry out on machine for making water-bindered pills.