CN105748303A - Dendrobium candidum small-molecule peptide facial mask - Google Patents
Dendrobium candidum small-molecule peptide facial mask Download PDFInfo
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- CN105748303A CN105748303A CN201610207761.3A CN201610207761A CN105748303A CN 105748303 A CN105748303 A CN 105748303A CN 201610207761 A CN201610207761 A CN 201610207761A CN 105748303 A CN105748303 A CN 105748303A
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- dendrobium candidum
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- molecular peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a dendrobium candidum small-molecule peptide and a dendrobium candidum small-molecule peptide facial mask prepared by using the same. The dendrobium candidum small-molecule peptide facial mask comprise facial mask cloth and an essence, and is characterized in that the essence consists of the following components in percentage by mass: 84.05% of water, 0.1% of carbomer, 6.0% of glycerol, 1% of dendrobium candidum small-molecule peptide, 1.0% of polyethylene glycol-32, 0.03% of xanthan gum, 0.02% of EDTA-2Na, 1.0% of betaine, 4.0% of 1,3-butanediol, 1.0% of beta-glucan, 1.0% of chondrus crispus, 0.1% of triethanolamine, 0.3% of PEG-40 hydrogenated castor oil, 0.1% of a flavor, 0.18% of 3-iodopropynyl butylcarbamate and 0.12% of dihydroxymethyl dimethyl hydantoin. The dendrobium candidum mask disclosed by the invention contains the dendrobium candidum small-molecule peptide, and can repair damaged skins, inhibit bacterial reproduction and effectively whiten, moisten and resist oxidation by integrating advanced normal-temperature high-pressure pretreatment, composite enzymatic hydrolysis, microfiltration, ultrafiltration and an integration technology thereof.
Description
Technical field
The present invention relates to the formulation art of cosmetics, specifically disclose a kind of dendrobium candidum small-molecular peptides facial mask.
Background technology
In the market, dendrobium candidum mainly extracts polysaccharide for preparing medicine for oral administration, for the extraction profit of small-molecular peptides
With the most fewer.The present invention extracts dendrobium candidum small-molecular peptides, is used for preparing facial mask.Traditional decoction extraction method is easily destroyed
Dendrobium candidum small-molecular peptides, and common polishing can comprise more impurity, is not easy to isolate small-molecular peptides.These are conventional
The efficiency that method obtains dendrobium candidum small-molecular peptides is the lowest, and therefore we need to explore new method.Modern science shows, iron sheet
Stem of noble dendrobium small-molecular peptides has hemostasis, has hemostasis, the effect of promotion wound healing, can be used for outward repairing damaged skin.It is demonstrated experimentally that iron
Skin stem of noble dendrobium small-molecular peptides can make wound location obtain mechanical protection, strengthens skin repair ability, makes wound faster heal, also simultaneously
There is the effects such as skin whitening, moisturizing is anti-oxidant.And the most in the market, the occupation rate of dendrobium candidum small-molecular peptides facial mask is the least
, so dendrobium candidum small-molecular peptides facial mask has the biggest development prospect.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of dendrobium candidum small-molecular peptides and the iron utilizing it to make
Skin stem of noble dendrobium small-molecular peptides facial mask.
The technical solution adopted in the present invention is:
A kind of dendrobium candidum small-molecular peptides facial mask, including facial mask cloth and Essence, being divided by following quality of described Essence
The one-tenth of number is grouped into: water 84.05, carbomer 0.1, glycerine 6.0, dendrobium candidum small-molecular peptides 1, polyethylene glycol-32 1.0, the Chinese are raw
Glue 0.03, EDTA-2Na 0.02, glycine betaine 1.0,1,3 butylene glycol 4.0, beta glucan 1.0, Chondrus crispus 1.0, three ethanol
Amine 0.1, Cremophor RH40 0.3, essence 0.1, IPBC (IPBC) and dihydroxymethyl two
Methyl hydantoin (3:2) 0.3.
The dendrobium candidum facial mask of the present invention adds dendrobium candidum small-molecular peptides, can repair damaged skin, and suppression bacterium is numerous
Growing, energy whitening effect moisturizing is anti-oxidant.
Further, described facial mask cloth is stealthy silk mask paper.
Further, the preparation method of described dendrobium candidum small-molecular peptides is: use normal temperature high voltage pretreatment dendrobium candidum,
Obtain high degree of dispersion dendrobium candidum pretreatment fluid；Process dendrobium candidum pretreatment fluid with complex enzyme and obtain dendrobium candidum small-molecular peptides
Enzymolysis liquid；The dendrobium candidum small-molecular peptides lysate obtained is purified, it is thus achieved that dendrobium candidum small-molecular peptides.
Further, the method for described purifying is particularly as follows: carry out micro-successively to described dendrobium candidum small-molecular peptides lysate
Filter, ultrafiltration and glucose gel purify, and the final molecular weight obtaining dendrobium candidum small-molecular peptides is 1000～2000Da.
Further, the pretreatment of described normal temperature high voltage, particularly as follows: dendrobium candidum is dried, is pulverized, and crosses 60 mesh sieves, by gained powder
End adds water, stirs, and soaks 1Omin and softens；Regulation low-temperature circulating pump bound temperature is-10 DEG C～-4 DEG C, will mixing
High pressure homogenizer poured into by material, and first material is poured under 5～l0MPa pressure conditions, and then control valve is to 40-50MPa, waits to press
After strong stability, homogeneous 3 times；Under the conditions of gained homogenizing fluid 4000r/min, centrifugal 20min, collects supernatant.
Further, described complex enzyme is processed as alkali protease Alcalase 2.4L, and enzymatic hydrolysis condition is: enzyme-to-substrate
Concentration ratio is 6%, temperature 50 C, pH=8.5, and the reaction time is 8h；Or tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration
Ratio is 6%, temperature 42 DEG C, pH=8.0, and the reaction time is 8h；Or alkali protease 37017, enzymatic hydrolysis condition is: enzyme-to-substrate is dense
Degree ratio is 3%, and temperature 50 C, pH=8.5, the reaction time is 8h.
On the other hand, the present invention also disclosed the preparation method of a kind of dendrobium candidum small-molecular peptides, comprises the following steps:
(1) use normal temperature high voltage pretreatment dendrobium candidum, obtain high degree of dispersion dendrobium candidum pretreatment fluid；(2) process with complex enzyme
To small-molecular peptides enzymolysis liquid；(3) the dendrobium candidum small-molecular peptides lysate obtained is purified.
Further, described step (1), particularly as follows: dendrobium candidum is dried, is pulverized, and crosses 60 mesh sieves, is added by gained powder
Water, stirs, and soaks 1Omin and softens；Regulation low-temperature circulating pump bound temperature is-10 DEG C～-4 DEG C, is fallen by mixed material
Entering high pressure homogenizer, material is first under 5～l0MPa pressure conditions, and then control valve is to required pressure, after pressure is stable,
Homogeneous is for several times；Under the conditions of gained homogenizing fluid 4000r/min, centrifugal 20min, collects supernatant.
Further, described step (2) is particularly as follows: alkali protease Alcalase 2.4L, and enzymatic hydrolysis condition is: enzyme and the end
Substrate concentration ratio is 6%, temperature 50 C, pH=8.5, and the reaction time is 8h；Or tryptic enzymatic hydrolysis condition is: enzyme-to-substrate is dense
Degree ratio is 6%, and temperature 42 DEG C, pH=8.0, the reaction time is 8h；Or alkali protease 37017, enzymatic hydrolysis condition is: enzyme-to-substrate
Concentration ratio is 3%, temperature 50 C, pH=8.5, and the reaction time is 8h.
Further, the purification process in described step (3) includes that micro-filtration, ultrafiltration and glucose gel purify.
The present invention utilizes Meizhou distinguishing products dendrobium candidum small-molecular peptides to be core, captures the system of international modern agricultural development
High point, utilize the normal temperature high voltage of integrated advanced person to pre-process, complex enzyme hydrolysis, micro-filtration, ultrafiltration and integrated technology thereof, build strong adaptability
Efficiently separate dendrobium candidum small-molecular peptides preparation technology, it is achieved preparation quick, efficient and the scale to dendrobium candidum small-molecular peptides
Change application, optimize facial mask technical recipe, research and develop dendrobium candidum mask product, and realize industrialization.
In order to be more fully understood that and implement, the following detailed description of the present invention.
Accompanying drawing explanation
Accompanying drawing 1 is the fabrication processing figure of the dendrobium candidum small-molecular peptides facial mask of the present invention
Detailed description of the invention
[embodiment 1]
Refer to accompanying drawing 1, including the technology of preparing of dendrobium candidum small-molecular peptides.
1, normal temperature high voltage pretreatment and complex enzyme hydrolysis technology of preparing
According to the design feature of dendrobium candidum protein, normal temperature high voltage preconditioning technique is used to obtain high degree of dispersion iron sheet stone
Dry measure used in former times pretreatment fluid, according to the design feature of dendrobium candidum protein, uses normal temperature high voltage preconditioning technique to obtain high degree of dispersion iron sheet
Stem of noble dendrobium pretreatment fluid concrete operations: dendrobium candidum dries (40 DEG C), pulverize, and cross 60 mesh sieves, and gained powder is added certain proportion
Water, stir, soak l Omin soften.Regulation low-temperature circulating pump bound temperature is-10 DEG C one-4 DEG C, it is ensured that homogenizer
Internal temperature is normal temperature.Mixed material is poured into high pressure homogenizer, and first under the conditions of low pressure (5-l0MPa) material, is then adjusted
Joint valve is to 40～50MPa, and after pressure is stable, homogeneous is for several times；Centrifugal 20min under the conditions of gained homogenizing fluid 4000r/min.Receive
Collection supernatant, residue is dried and is preserved.
Complex enzyme treatment technology is used to obtain small-molecular peptides enzymolysis liquid:
Actual conditions: the enzymatic hydrolysis condition of alkali protease Alcalase 2.4L is: enzyme-to-substrate concentration ratio (E/S) is
6%, temperature 50 C, pH=8.5, the reaction time is 8h.Tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio (E/S) is
6%, temperature 42 DEG C, pH=8.0, the reaction time is 8h.The enzymatic hydrolysis condition of alkali protease 37017 is: enzyme-to-substrate concentration ratio
(E/S) being 3%, temperature 50 C, pH=8.5, the reaction time is 8h.
2, dendrobium candidum small-molecular peptides separating and purifying technology
According to the design feature of the little molecule of dendrobium candidum, use the skills such as micro-filtration, ultrafiltration and Sephadex G desalting and purifying thereof
Art prepares dendrobium candidum small-molecular peptides, it is thus achieved that the final molecular weight of dendrobium candidum small-molecular peptides is 1000～2000Da.
[embodiment 2] preparation facial mask essence and facial mask packaging
Refer to accompanying drawing 1, wherein facial mask essence configuration and the process of packed products.
The composition of the facial mask of the present invention is as follows:
The preparation method of the facial mask of the present invention is as follows: above-mentioned dispensing be sufficiently mixed, and stirring homogeneous is to transparent or semitransparent
Emulsion form obtains facial mask essence；By facial mask essence censorship, fill according to 15 milliliters of amounts often pasted after every physical and chemical index is qualified
Load in the prior packaging bag equipped with silk invisible face pack paper, encapsulation.
[embodiment 3] product quality detects
Microbiological Test: inspection project has total plate count, excrement colibacillus group, Pseudomonas aeruginosa, staphylococcus aureus, mould
Bacterium and saccharomycete.Evaluation criterion: total plate count≤1 000cfu/ml (g)；Yeast and mold sum≤100cfu/ml (g)；
Excrement colibacillus group, Pseudomonas aeruginosa, staphylococcus aureus must not detect.All appearance >=1 index is non-compliant to be judged to
Failed test sample.
[embodiment 4] clinical practice
Dry and astringent to 30 example skins, be a bit darkish in color, subject that pigmentation is serious carries out 1 month trying out, design simultaneously
It is added without the control group of dendrobium candidum small-molecular peptides, observing effect, observes side effect and bad reaction.
Efficacy assessment standard:
Effective: with after facial mask 15～20 days, the colour of skin substantially highlighted, the most dark yellow, and skin water is tender glossy, and microgroove is thin out.
Effective: with after facial mask 21～29 days, the colour of skin highlighted, the most dark yellow, and skin water is tender glossy, and microgroove is thin out.
Invalid: using facial mask 30 days, skin remains unchanged dark yellow dry and astringent without moisture.
Calculate efficient with effective and effective case.
Result for the treatment of such as following table
It can be seen that this facial mask has certain moisturizing, whitening and antibacterial functions through preliminary trying out from data above, available
In daily skin nursing.
The invention is not limited in above-mentioned embodiment, if various changes or deformation to the present invention are without departing from the present invention
Spirit and scope, if these are changed and within the scope of deformation belongs to claim and the equivalent technologies of the present invention, then this
Bright being also intended to comprises these changes and deformation.
Claims (10)
1. a dendrobium candidum small-molecular peptides facial mask, including facial mask cloth and Essence, it is characterised in that described Essence by with
The one-tenth of lower mass fraction is grouped into: water 84.05, carbomer 0.1, glycerine 6.0, dendrobium candidum small-molecular peptides 1, polyethylene glycol-
321.0, xanthan gum 0.03, EDTA-2Na 0.02, glycine betaine 1.0,1,3 butylene glycol 4.0, beta glucan 1.0, Chondrus crispus
1.0, triethanolamine 0.1, Cremophor RH40 0.3, essence 0.1, IPBC 0.18 and two
Methylol dimethyl hydantion 0.12.
Dendrobium candidum small-molecular peptides facial mask the most according to claim 1, it is characterised in that described facial mask cloth is stealthy silk
Face paper.
Dendrobium candidum small-molecular peptides facial mask the most according to claim 1, it is characterised in that described dendrobium candidum small-molecular peptides
Preparation method be: use normal temperature high voltage pretreatment dendrobium candidum, obtain high degree of dispersion dendrobium candidum pretreatment fluid；Use complex enzyme
Process dendrobium candidum pretreatment fluid and obtain dendrobium candidum small-molecular peptides enzymolysis liquid；To the dendrobium candidum small-molecular peptides lysate obtained
It is purified, it is thus achieved that dendrobium candidum small-molecular peptides.
Dendrobium candidum small-molecular peptides facial mask the most according to claim 3, it is characterised in that the method for described purifying is concrete
For: described dendrobium candidum small-molecular peptides lysate is carried out successively micro-filtration, ultrafiltration and glucose gel and purifies, finally obtain iron sheet
The molecular weight of stem of noble dendrobium small-molecular peptides is 1000～2000Da.
Dendrobium candidum small-molecular peptides facial mask the most according to claim 3, it is characterised in that described normal temperature high voltage pretreatment tool
Body is: dendrobium candidum is dried, and pulverizes, and crosses 60 mesh sieves, gained powder is added water, stirs, and soaks 1Omin and softens；Regulation
Low-temperature circulating pump bound temperature is-10 DEG C～-4 DEG C, pours into high-pressure homogeneous by mixed material under 5～10MPa pressure conditions
Machine, then control valve is to 40-50MPa, after pressure is stable, homogeneous 3 times；It is centrifuged under the conditions of gained homogenizing fluid 4000r/min
20min, collects supernatant.
Dendrobium candidum small-molecular peptides facial mask the most according to claim 3, it is characterised in that described complex enzyme is processed as alkalescence
Protease A lcalase 2.4L, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 50 C, pH=8.5, the reaction time
For 8h；Or tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 42 DEG C, pH=8.0, the reaction time is
8h；Or alkali protease 37017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 3%, temperature 50 C, pH=8.5, the reaction time
For 8h.
7. a preparation method for dendrobium candidum small-molecular peptides, comprises the following steps: (1) uses normal temperature high voltage pretreatment iron sheet stone
Dry measure used in former times, obtains high degree of dispersion dendrobium candidum pretreatment fluid；(2) small-molecular peptides enzymolysis liquid is obtained with complex enzyme process；(3) to acquisition
Dendrobium candidum small-molecular peptides lysate is purified.
Preparation method the most according to claim 6, it is characterised in that described step (1) particularly as follows: dendrobium candidum dry,
Pulverize, cross 60 mesh sieves, gained powder is added water, stirs, soak 1Omin and soften；Regulation low-temperature circulating pump bound temperature
Mixed material, for-10 DEG C～-4 DEG C, is poured into high pressure homogenizer by degree, and material, first under 5～10MPa pressure conditions, then regulates
Valve is to required pressure, and after pressure is stable, homogeneous is for several times；Under the conditions of gained homogenizing fluid 4000r/min, centrifugal 20min, collects
Supernatant.
Preparation method the most according to claim 6, it is characterised in that described step (2) is particularly as follows: alkali protease
Alcalase2.4L, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 50 C, pH=8.5, and the reaction time is 8h；Or
Tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 42 DEG C, pH=8.0, and the reaction time is 8h；Or alkalescence
Protease 3 7017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 3%, temperature 50 C, pH=8.5, and the reaction time is 8h.
The preparation method of dendrobium candidum small-molecular peptides the most according to claim 7, it is characterised in that in described step (3)
Purification process include that micro-filtration, ultrafiltration and glucose gel purify.
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| CN201610207761.3A CN105748303A (en) | 2016-04-01 | 2016-04-01 | Dendrobium candidum small-molecule peptide facial mask |
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| CN201610207761.3A CN105748303A (en) | 2016-04-01 | 2016-04-01 | Dendrobium candidum small-molecule peptide facial mask |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333912A (en) * | 2016-11-11 | 2017-01-18 | 福建师范大学 | Preparation method of dendrobium officinale essence |
| CN106420527A (en) * | 2016-11-11 | 2017-02-22 | 福建师范大学 | Preparation method of moistening cream containing dendrobium officinale |
| CN107281082A (en) * | 2017-06-29 | 2017-10-24 | 广州大澳化妆品有限公司 | A kind of nutrient solution containing small-molecular peptides and the facial mask and preparation method including it |
| CN108078856A (en) * | 2018-01-18 | 2018-05-29 | 凌中鑫 | A kind of small-molecular peptides facial mask cloth and its production method |
| CN115501133A (en) * | 2022-09-01 | 2022-12-23 | 优得多糖技术无锡有限公司 | Sour soybean seed polysaccharide, preparation method thereof and application thereof in preparation of products with skin care effect |
-
2016
- 2016-04-01 CN CN201610207761.3A patent/CN105748303A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333912A (en) * | 2016-11-11 | 2017-01-18 | 福建师范大学 | Preparation method of dendrobium officinale essence |
| CN106420527A (en) * | 2016-11-11 | 2017-02-22 | 福建师范大学 | Preparation method of moistening cream containing dendrobium officinale |
| CN107281082A (en) * | 2017-06-29 | 2017-10-24 | 广州大澳化妆品有限公司 | A kind of nutrient solution containing small-molecular peptides and the facial mask and preparation method including it |
| CN108078856A (en) * | 2018-01-18 | 2018-05-29 | 凌中鑫 | A kind of small-molecular peptides facial mask cloth and its production method |
| CN115501133A (en) * | 2022-09-01 | 2022-12-23 | 优得多糖技术无锡有限公司 | Sour soybean seed polysaccharide, preparation method thereof and application thereof in preparation of products with skin care effect |
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Application publication date: 20160713 |