CN105748108B - A kind of device - Google Patents
A kind of device Download PDFInfo
- Publication number
- CN105748108B CN105748108B CN201610101022.6A CN201610101022A CN105748108B CN 105748108 B CN105748108 B CN 105748108B CN 201610101022 A CN201610101022 A CN 201610101022A CN 105748108 B CN105748108 B CN 105748108B
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- China
- Prior art keywords
- cavity
- moving element
- fluid
- carrier
- sample
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48714—Physical analysis of biological material of liquid biological material by electrical means for determining substances foreign to the organism, e.g. drugs or heavy metals
Abstract
The present invention relates to the devices for collecting and detecting fluid sample, including the first cavity and the second cavity, wherein, first cavity is located in the second cavity, and the first cavity is connected with the second cavity, first cavity and the second cavity, which can be rotated mutually, flows fluid between the first cavity and the second cavity, and the first cavity has first position and the second position in the second cavity.The device of the invention can make to be sufficiently mixed positioned at the intracorporal fluid of the second chamber, achieve the purpose that fluid is uniformly mixed, to be more advantageous to the detection of next step.
Description
The application is Chinese invention patent application, application number: 201210409899.3 divisional application.
Technical field
The present invention relates to a kind of devices, especially for collecting and detecting the device of fluid sample.
Background technique
Following background technique is used to help reader and understands the present invention, and is not construed as the prior art.
In our society, illicit drug use has become the social concern generally acknowledged and deteriorated increasingly.2003
Year, U.S. Department of Health and Human Service investigation discovery there are about 19,500,000 Americans or 8.2% age 12 years old or more crowd just
Sucking illicit drugs." using illicit drugs recently ", which refers to, investigate in the previous moon in U.S. Department of Health and Human Service
Used a kind of illicit drugs.Hemp is found to be most common illicit drugs, accounts for 6.2% (14,600,000).Estimate 2,300,000 people
(1.0%) ***e is used now, 604,000 people have used crack, and there are 1,000,000 people using psychedelic, and estimate 119,
Heroin is used in 000 people.
United States Patent (USP) US2004/0184954 and US2004/0237674 disclose other and collect saliva and examined
Survey saliva in whether the device containing illicit drugs ingredient.In the two patents, both provides collection and detect the dress of saliva
It sets and method, it, will be on collector in absorption piece by applying external force after sample is sampled on collector in these devices
Sample be expressed in collecting chamber, then detected again.But sample collection stick cooperates in extrusion process with collecting chamber,
It might have sample contact to pollute or infect to operator；Also, after encountering sample and needing first to mix with buffer again
In the case where being detected, such collection device just seems not very convenient.
Therefore better method and device is needed to be collected and detect sample.
Summary of the invention
The present invention provides new device, and sample can be made to be sufficiently mixed with buffer liquid, facilitates the detection of next step.
On the one hand, the present invention provides a kind of device, which includes: the first cavity and the second cavity, wherein the first cavity
In the second cavity, and the first cavity is connected with the second cavity, and first cavity and the second cavity can be relatively
Movement flows fluid between the first cavity and the second cavity.
Preferably, the first cavity is connected with the second cavity fluid, i.e., fluid can the first cavity and the second cavity it
Between circulated or transmitted.It include the opening for being connected to the first cavity and the second cavity on the first cavity, fluid passes through the opening
It is flowed into the second cavity.
In some preferred modes, the first cavity has first position and the second position in the second cavity.
In the preferred mode of other, when the first cavity is moved to second relative to the second cavity by first position
When setting, the space of the first cavity or volume change, and the change of volume promotes fluid to be flowed into the second cavity from the first cavity
In.
In some preferred modes, in the first cavity during space or volume change, the first cavity is made way for
Interior fluid is flowed into the second cavity.In some modes, the first cavity is made way for during space or volume change
The intracorporal fluid of first chamber is irreversibly flowed into the second cavity.
In some preferred modes, the first cavity space and/or volume change are that volume and/or space become smaller.
In some preferred modes, when the first cavity turns to the second position relative to the second cavity by first position
When, the space of the first cavity becomes smaller, which makes way for the intracorporal fluid of the first chamber and be flowed into the second cavity during becoming smaller
In；Alternatively, the space of the first cavity is restored to original state, i.e., first when the first cavity turns to first position by the second position
When cavity is in first position, fluid can also be flowed into the first cavity out of second cavity.
In some preferred specific embodiments, the first cavity passes through opening on open side wall or the first cavity wall
Mouth and the second cavity configured in fluid communication.In other specific embodiments, which further includes movable moving element, such as
Card slot, opening on moving element mating connection wall simultaneously can move in the first cavity the first cavity volume allowed to become smaller.It is preferred that
Mode in, movable element is located in the first cavity.In some modes, when the first cavity is in the relative to the second cavity
When one position, moving element is lived when mobile relative to the second cavity in the process of moving far from the first cavity
Dynamic element moves closer to or enters in the first cavity, squeezes the first cavity or enters the first cavity and the volume of the first cavity is allowed to send out
Changing, such as become smaller, the variation of volume is made way for the fluid in the first cavity and is flowed in the second cavity from the first cavity.One
In a little modes, a part of movable card slot is located in the opening of the wall of the first cavity, another part of card slot and the second cavity
Inner wall contact, the first cavity allows card slot to allow the first cavity by being open to enter in the first cavity with respect to the movement of the second cavity
Volume become smaller.
In one embodiment, on moving element, such as card slot, there is the protrusion cooperated with the second cavity, when the first chamber
When body and the second cavity rotate, it is mobile to the first inside cavity that the second cavity pushes protrusion to make moving element, to allow the first chamber
The volume of body becomes smaller.In some modes, the first cavity includes two symmetrical openings, passes through the opening and the second cavity fluid
Connection includes correspondingly two symmetrical mobilizable moving elements or card slot in symmetrical two openings.When
When one cavity moves in the second cavity, symmetrical moving element, which enters in the first cavity or squeezes, allows the in the first cavity
The volume of one cavity changes, such as becomes smaller, and makes way for the fluid in the first cavity and is flowed into the second cavity.In some sides
In formula, symmetrical moving element, such as card slot, between can there is installation to have elastic component, such as spring is close to each other
In the process, distance is reduced between card slot, to allow the first cavity volume to reduce, or directly compression is located at the stream in the first cavity
Body sample absorbance carrier, conversely, then increasing the volume of the first cavity or reducing the compression to carrier.
In some preferred modes, the carrier adsorption that can extrude or compress positioned at the intracorporal fluid sample of the first chamber,
In its natural state, fluid sample is attracted in carrier, without flowing, when carrier is compressed, is located at and is carried
Fluid sample on body is squeezed out outside carrier.In conjunction with some embodiments of top, since the volume of the first cavity has occurred
Variation, such as reduce, it can squeeze in the intracorporal carrier of the first chamber, so that the fluid on carrier be allowed to pass through card slot and the first chamber
The gap reserved between body wall upper opening flows in the second cavity.In some preferred modes, movable card slot is directly squeezed
It is adsorbed with the carrier of fluid sample.
In other embodiments, which further includes sample collection stick, and collecting stick includes the carrier that can be compressed.This can
Compressed carrier is for adsorbing or having collected fluid sample.In some specific embodiments, sample collection stick and first
Cavity cooperation, enables the first cavity mutually to rotate with the second cavity.
In specific embodiment, moving element includes the channel for allowing fluid to flow into the second cavity from the first cavity.Block
There is the groove that fluid can be allowed to flow on slot, be flowed into the second cavity out of first cavity by groove by fluid.
There is the strip that can cooperate with the first cavity wall in another specific embodiment, on card slot.
In other embodiments, which further includes the third cavity for being connected and being connected to the first cavity.It is preferred that
Mode in, the first cavity is fixedly connected with third cavity, can allow the first cavity and third cavity together simultaneously in the second chamber
It is mobile in vivo.In preferred mode, there is puncturing elements, such as sheet protrusion on third cavity lateral wall.More preferably, piece
Shape protrusion is located at the monosymmetric position of upper third chamber.In some embodiments, which further includes equipped with fluid or buffering
The seal of fluid (buffer solution) being punctured, the seal is between the second cavity and third cavity.Fluid or
Buffer fluid is mainly treatment fluid sample, such as is diluted, and is eluted, and extraction removes the functions such as the impurity in fluid sample.It can
The seal being punctured can be had sheet protrusion to puncture on third cavity lateral wall.
In other mode, the seal that can be punctured is located in the first cavity, when card slot enters the first cavity
Moving process can puncture seal, to discharge fluid therein, which can be directly entered in the second cavity, can also be with
Fluid sample mixing on carrier, elutes the fluid sample etc. on carrier, is flowed into second together then as fluid sample
In cavity.
In some specific embodiments, the first cavity further includes the third place in the second cavity；When the first cavity
When turning to the third place by the second position, size is restored in the space of the first cavity, and fluid is flowed into first out of second cavity
In cavity；When the first cavity turns to the second position by the third place, the space of the first cavity becomes smaller, and fluid is from the first cavity
It is flowed into the second cavity.
In some preferred embodiments, when the first cavity turns to the second position or by first position or the third place
When four positions, two card slots are mobile to the inside of the first cavity, its space is made to become smaller, and squeeze and are located at the intracorporal carrier of the first chamber,
And it is flowed into fluid in the second cavity from the first cavity.
In more specific embodiment, when the first cavity by the second position turn to first position by or the 4th position move
When moving the third place, carrier is displaced outwardly two card slots by the first inside cavity, and the space of the first cavity is made to restore original
State, such as volume is as first position, and is flowed into fluid again in the first cavity from the second cavity.
In another specific embodiment, the first cavity further includes the 4th position in the second cavity；When the first cavity
When turning to four positions by first position or the third place, the space of the first cavity becomes smaller, and fluid is flowed into from the first cavity
In second cavity.
In another embodiment, when the first cavity is moved from four-position rotation to first position or the third place,
Size is restored in the space of one cavity, and fluid is flowed into the first cavity from the second cavity.
In some specific embodiments, when the first cavity by first position or the third place turn to the second position or
When four positions, sheet protrusion pokes the seal between the second cavity and third cavity.
In other embodiments, which further includes the test chamber containing testing element, the test chamber and the second cavity
Configured in fluid communication.
In the present invention, it in order to allow the relative motion in the second cavity of the first cavity, allows in the first cavity and the second chamber
Moving element between body, such as movable card slot, into or out of the first cavity, so that the volume of the first cavity be allowed to become
Change, the fluid made way in the first cavity that the variation of volume can be direct or indirect, such as fluid sample, from the first cavity stream
Enter into the second cavity.In some modes, mobile mode is rotating manner.This mode being mutually shifted setting when
Wait, if allow moving element be in when the first cavity be in first position with the first cavity the second position when, it is movable
Element is changed in the position on the first cavity, such as closer to or deeper into can in the first cavity.For example,
Line distance on second cavity inner wall between any first two o'clock is a and in addition the line distance between any second two o'clock is
B, wherein a is greater than b, and the sum of the distance between length of moving element itself and moving element are c, and wherein c is greater than b.In this way, working as
When moving element is moved on shorter line from other position, due between the length of moving element itself and they
The length of distance is greater than on the shorter line of the second cavity, in this way reduces necessarily the distance between moving element, and distance subtracts
It less can be with compression vehicle.In some preferred modes, moving element is any in the second cavity when first position
On the longer line of first two o'clock, such as line a；When moving element is in the second position, moving element is in the
In two cavitys on the line length b of other any second two o'clock.Such setting is in addition to being arranged the irregular shape of the second cavity
It is this that the changed mode in moving element position is allowed to can be in the inner wall setting protrusion of the second cavity or recessed portion outside shape
Part allows line between the second cavity inner wall arbitrary point the movement of moving element thus may be implemented, change apart from unequal
The distance between moving element.In some preferred modes, the movement of the mobile drive moving element of the first cavity or transfer.
In a more preferred manner, the movement of the drive moving element of the mobile synchronization of the first cavity, such as moving element are attached to the
In one cavity.
In other embodiments, the second cavity is Elliptic Cylinder, and the first cavity is rectangular parallelepiped structure, at the first cavity
When first position, the distance of moving element is on the longest range line of Elliptic Cylinder, when the first cavity is in second
When position, the distance of moving element is on the shortest range line of Elliptic Cylinder.
On the other hand, in the preferred mode of other, the present invention provides a kind of device, when the first cavity is by first
It sets when being moved to the second position relative to the second cavity, the space of the first cavity or volume do not change, and make way for
Moving element between one cavity and the second cavity is mobile, and mobile moving element compression is located at can be compressed in the second cavity
Carrier, make way for the fluid sample on carrier and be flowed into the second cavity.
For example, in a specific embodiment, the present invention provides a device that, which includes: the first cavity
With the second cavity, wherein the first cavity is located in the second cavity, and the first cavity is connected with the second cavity, and is located at
Moving element between first cavity and the second cavity, first cavity and the second cavity, which can be moved relatively, makes movable member
The distance between part is reduced.
In a preferred mode, the load that can be compressed for being adsorbed with liquid sample is provided between moving element
Body.Compression vehicle after the distance between moving element is reduced.In some preferred modes, piecemeal activity element is located at first
On cavity, rotation of first cavity in the second cavity drives moving element mobile.The movement of this moving element is to enter the
The movement of one cavity, in the present embodiment, the carrier that can be compressed can be located in advance in the first cavity, work as moving element
When entering the first cavity in opposite directions, compression vehicle allows the liquid sample in carrier to flow out.In some preferred modes, first
Cavity includes some openings, and moving element is entered in the first cavity by opening.Certainly, in some preferred modes, absorption
Having the compressible carrier of fluid sample can be located on fluid specimen collection device, first collect fluid sample, such as mouth with carrier
Middle collection saliva, is then inserted into the first cavity, allows carrier between moving element or, the position that can be compressed by moving element
It sets.
For example, providing a kind of device, comprising: the first chamber for having the carrier of liquid sample for accommodating compressible collection
Body；Second cavity, and the moving element between the first cavity and the second cavity, wherein the first cavity is located at the second cavity
It is interior, and the first cavity is connected with the second cavity fluid, and the first cavity drives moving element to rotate in the second cavity, activity
The intracorporal carrier of the first chamber is compressed in the rotation of element.
It include opening on the wall of first cavity, one end of moving element passes through opening and is located in the first cavity, and the other end leans on
The inner wall of nearly second cavity.
The moving element is two and to be oppositely arranged, and the moving element being oppositely arranged has the of first position
One distance and second distance in the second position, wherein first distance is greater than second distance.When moving element is located at first position
When, moving element is located on the line in the second cavity inner wall between the first two o'clock；When moving element is located at second
When setting, moving element is located on the line in the second cavity inner wall between the second two o'clock, wherein between the first two o'clock
Distance is greater than the distance between second two o'clock.
The carrier that can be compressed is located between the moving element of opposition setting.The device further includes sample collection stick, is collected
Stick includes the carrier for collecting fluid sample.The sample collection stick and the first cavity cooperate, and drive the first cavity second
Rotation in cavity.The rigidity of moving element is greater than the rigidity of compressible carrier.
Moving element is moved to the second position from first position, and the distance between moving element for the setting that opposes is reduced, from
And the carrier collected and have fluid sample is compressed, allow fluid sample to be flowed into cavity from carrier.
The opening on inner wall that the fluid passes through the first cavity enters in the second cavity.
On the other hand, the present invention provides a kind of detection method, comprising: provides a kind of detection dress, which includes
Second cavity and the first cavity positioned at the second cavity kind, first cavity are used to accommodate fluid sample；Make the first cavity opposite
It is rotated in the second cavity, allows the volume of the first cavity to change by rotation；Wherein, the variation of the volume allows in the first cavity
Fluid sample enter in the second cavity.In some preferred modes, which includes moving element, the first cavity
Moving element is driven to rotate in the second cavity, the rotation of moving element allows the volume of the first cavity to reduce.It is furthermore preferred that described
Fluid sample be attracted on compressible carrier, moving element rotation to compress the carrier.Preferably, activity member
The carrier that the rotation of part makes moving element compression described.
Beneficial effect
The device of the invention can simpler collection fluid sample, facilitate storage and transport；In addition, the first chamber is intracorporal
Fluid adequately flows into the second cavity, and make be located at the intracorporal fluid of the second chamber be sufficiently mixed, especially sample with
Buffer liquid can be sufficiently mixed, and achieve the purpose that fluid is uniformly mixed, to be more advantageous to the detection of next step.
Detailed description of the invention
Fig. 1 is the stereoscopic schematic diagram of a device of the invention；
Fig. 2 is the cross-sectional view of apparatus of the present invention；
Fig. 3 is the explosive decomposition figure of apparatus of the present invention；
Fig. 4 is moving element-card slot schematic diagram in apparatus of the present invention；
Fig. 5 is the schematic diagram of moving element-card slot another side in apparatus of the present invention；
Fig. 6 is the first cavity and third cavity schematic diagram in apparatus of the present invention；
Fig. 7 is sample collection stick schematic diagram of the invention；
Fig. 8 is the connection schematic diagram of apparatus of the present invention the second cavity and detection device；
Fig. 9 is the positional diagram (first position or the third place) of the first cavity and the second cavity；
Figure 10 is one status diagram of apparatus of the present invention (first position or the third place)；
Figure 11 is the A-A sectional view schematic diagram of Figure 10 state；
Figure 12 is another status diagram (second position or the 4th position) of apparatus of the present invention；
Figure 13 is the A-A sectional view schematic diagram of Figure 12 state；
Figure 14 is the schematic diagram of one embodiment of the present invention.Figure 14 A indicates that the first cavity is in initial first position, living
Dynamic element 51 is initial position, and Figure 14 B indicates that the first cavity is in the second position, moving element 51 moved into the first cavity and
Compression vehicle.From this figure, it can be seen that due to the shape of the second cavity and the shape of the first cavity is different with positional relationship sets
It sets, with opposite movement, so that the position of moving element be allowed to change, finally allows the direct compression vehicle of moving element and release
Put fluid sample.
Figure 15 is the schematic diagram of one embodiment of the present invention.Figure 15 A indicates that the first cavity is in initial first position, living
Dynamic element 51 is initial position, and Figure 15 B indicates that the first cavity is in the second position, moving element 51 moved into the first cavity and
Compression vehicle.From this figure, it can be seen that since although the shape of the second cavity does not change with the first cavity in the second cavity
Positional relationship it is different and allow moving element is mobile and compression vehicle.With opposite movement, to allow the position of moving element
It changes, finally allow the direct compression vehicle of moving element and discharges fluid sample.
Description of symbols:
Sample collection and detection device 500, the device of the invention 510, sample collection stick 520, detection device 530, first
Cavity 512, the opening 5121 of the open side wall of the first cavity or side wall, the side wall 5122 of the first cavity, the second cavity 511, the
Three cavitys 513, card slot 515, protrusion 5151 on card slot, strip 5152 on card slot, card slot upper groove 5153, washer 516, the second chamber
Body upper cover 517, the second cavity bottom gasket 518, buffer seal 5132, third cavity outside portion protrusion 5131, third chamber
Internal projected side wall 5133, sample collection stick are affectedly bashful portion 521, and the carrier 522 of sample collection stick is affectedly bashful the connection of portion and carrier
Bar 523 is affectedly bashful portion's groove 524, and detection device upper plate 531, detection device lower plate 532, detection device is in apparatus of the present invention correspondence
The protrusion 533 at place, first position 801, the second position 802, the third place 803, the 4th position 804；Moving element 51；
Specific embodiment
Structure of the present invention or technical term used in these are described further below.
Sample
" sample " that the present invention refers to refers to needing to chemically examine whether there is and (or) analyzing any of analyte concentration
Substance, or it needs to be determined that one or more samples whether there is and (or) the substance of the analyte of quantity, or need to carry out
The substance of qualitative evaluation.Sample can be fluid sample, such as fluid sample.Fluid sample includes body fluid, such as blood, blood
Clearly, blood plasma, saliva, urine, tears, sperm and marrow；Fluid sample is also possible to water sample, such as seawater, river, river water etc.,
Or from household water, municipal water or industrial water resource, runoff water or sewage；Sample can be food sample, such as ox
Milk and wine.Mucus, semisolid or solid sample can be used to make fluid, eluate, suspension or leachate equal samples.Example
Such as, throat or genitals sample may be dipped in and sample are made in fluid.Sample may include the mixing of fluid, solid and gas
Object or any relevant mixture, such as the cell suspending liquid in dilution or solution.Sample includes biological substance, such as carefully
Born of the same parents, microorganism, organelle and biochemical complexes.Fluid sample can from such as soil, excrement, tissue, organ, biological fluid or
The solids such as nonfluid sample, semisolid or high-viscosity material are produced in other natures.For example, these solid or semisolid samples
It can be mixed with a kind of solution appropriate of dilution.Sample can be macerated and flushed, freezes and thaw or other extracting methods are formed
Fluid sample.Traditional method removal such as filtering or precipitating can be used in remaining particulate material.
Testing element
" testing element " is the element of any executable test.In one embodiment, testing element is test-strips.The survey
Strip may include having the substance pair specifically bound for immunoassay on it.Test-strips can be a kind of detecting
At the rear test chemical item by color change or other signal intensity judging results.It is applicable in the sample that the present invention is detected
Including but not limited to body fluid, the sample separated from biological tissue or body fluid.For example, sample can be saliva, and blood, serum,
Blood plasma, urine, excreta, spinal fluid, vaginal secretion, mucus and tissue.Testing element is not limited to one, can be two or more
A testing element is located in detection device simultaneously, respectively different component in test sample.
Sample collection stick 520
The present invention also provides sample collection sticks 520.In one embodiment, sample collection stick 520 has an absorption carrier 522
With the portion of being affectedly bashful 521.Carrier 522 is absorbed usually to be made of the other sponge of medical grade commonly used in the art or plastic foam material.But
It is that many other materials may be made as absorbing carrier, such as cotton perhaps paper or other any materials with water absorbing properties.
Absorb carrier 522 have certain elasticity, when by external force pressure, can compression space and become smaller, and when external force reduce or disappear
When mistake, absorbing carrier can gradually restore to the original state.Sample collection stick can be in advance containing can stimulate the salivary solution of tester
Middle immersion.So that being easier to collect saliva when collecting stick and being put into tester mouthful.It is affectedly bashful portion to be usually rigid, favorably
In the operation to carrier is absorbed.The portion of being affectedly bashful can be made of material commonly used in the art, such as plastics, timber, metal or cardboard.
In the following detailed description, the subsidiary reference word of legend is a part here, it is to illustrate this
Invention can the mode of actable specific concrete scheme illustrate.The present invention, which is not precluded, in we can also carry out others specifically
Scheme and change structure of the invention without prejudice to use scope of the invention.
As shown in figure 14, in the specific embodiment of the present invention, in the second cavity 510 include carrier 522 and with
The moving element 51 that carrier is correspondingly arranged, moving element is in first position relative to the second cavity at this time, during this time, living
Dynamic element not compression vehicle, Figure 14 A.This when the distance between moving element H and moving element itself length (A+B)
On the axis C long in the second cavity.When rotary moveable element along the direction of the arrow, moving element is due to by second
The pressure of cavity inner wall allows the fluid sample in carrier to be come out from carrier by compression to intermediate close, compression vehicle, Figure 14 A,
This when of moving element is on the short axis D of the second cavity, and wherein the length of C is greater than the length of D.
Equally, in Figure 15, interior arbitrary point line of moving element when first position in the second cavity is longer
Distance, this when moving element not compression vehicle, when rotary moveable element, moving element is from the second cavity
The interior longer position of arbitrary point line is moved to the shorter position of interior arbitrary point line of the second cavity, this when moving element
Compression vehicle, so that the fluid on carrier is compressed out.Equally, in above specific implementation example, carrier can be by
It is placed into and later, it is corresponding with the position of moving element；In addition, carrier and moving element can also be housed in the first cavity
In, some openings are opened on the wall on the first cavity, one end of moving element is allowed to be located in the first cavity, and the other end is located at second
It is in cavity and close with the inner wall of cavity.Herein, moving element has more rigid for carrier, in this way may be used
To be effectively compressed carrier.
In the mode described in Figure 14 and 15, carrier be may be accommodated in the first cavity, and moving element passes through the first chamber
Body opening with the carrier in the first cavity can directly or indirectly contact.The movement of moving element in this way can allow the first chamber
The volume of body is reduced and compression vehicle or direct contact carrier and compression vehicle, so that the carrier for being adsorbed with fluid sample be allowed to squeeze
Carrier.
In other specific embodiment, as shown in figure 3, the device 510 includes the first chamber in one embodiment
Body 512 and the second cavity 511, wherein the first cavity 512 is located in the second cavity 511, as shown in Fig. 2 cross-sectional view, and first
Cavity 512 is connected with the second cavity 511.In a specific embodiment, the two passes through the opening on the first cavity wall
5121 are connected.The shape of first cavity 512 and the second cavity 511 is unlimited, it is only necessary to which can be accommodated by meeting the second cavity 511
One cavity 512 simultaneously guarantees the rotation that the first cavity 512 can be in the second cavity 511 freely, such as: it is cylindrical, cube
The bodily form, cuboid-type and cone etc..As shown in fig. 6, the first cavity 512 is the structure of cuboid, in four side walls
In, there are two corresponding side wall 5121 be it is open, i.e., symmetrical both sides are without side wall.And the second cavity 511 is Elliptic Cylinder
Length and width of the minor axis size of structure, inner hollow, also, the Elliptic Cylinder slightly larger than the cuboid of the first cavity.The
One cavity 512 is connected with the second cavity 511 by the side wall 5121 of the opening on the first cavity.More specifically, when first
When cavity 512 and the second cavity 511 mutually rotate, the fluid in the first cavity 512 passes through the two open side walls 5121
It is flowed into the second cavity 511, alternatively, the fluid in the second cavity 511 is flowed into the first cavity by the two side walls 5121
In 512.
First cavity 512 can be rotated freely in the second cavity 511, also, when two cavitys mutually rotate, and two
A intracorporal fluid of chamber can mutually be flowed by the mutual rotation of cavity.In some specific embodiments, the first cavity 512
When rotating in the second cavity 511, there is first position 801 and the second position 802 relative to the second cavity 511, such as Fig. 9 institute
Show.When the initial position of the first cavity and the second cavity is first position 801, i.e., when the first cavity is located at the first of the second cavity
It is original state when position 801.And when the first cavity 512 turns to the second position 802 by first position 801, the first cavity
512 space becomes smaller, and fluid is flowed into the second cavity 511 from the first cavity 512.Because the space in the first cavity 512 becomes smaller,
The fluid of intracavitary receiving will also tail off, and therefore, the fluid in originally the first cavity 512 is flowed by the inner sidewall 5121 that it is opened
Into the second cavity 511.And when the first cavity 512 proceeds to first position 801 by the second position 802, i.e., initial position when,
Then original size is restored in the interior space of the first cavity 512.At this point, the fluid in the second cavity 511 then passes through the interior of opening again
Side wall 5121 is flowed into the first cavity 512.To which first, the two intracorporal fluids of chamber realize circulation intercommunication.Other more into
In the embodiment of one step, the first cavity 512 further includes the third place 803 and the 4th position 804 in the second cavity 511, equally
As shown in figure 9, the third place is located at behind the second position 802 along 803 times, the 4th position 804 is located at behind the third place 803,
It and is first position 801 behind the 4th position 804.In specific embodiment, when the first cavity 512 is by 802 turns of the second position
When moving the third place 803, size is restored in the space of the first cavity 512, and fluid is flowed into the first cavity out of second cavity 511
In 512；When the first cavity 512 turns to the second position 802 by the third place 803, the space of the first cavity 512 becomes smaller, stream
Body is flowed into the second cavity 511 from the first cavity 512.And when the first cavity 512 is by first position 801 or the third place 803
When turning to four positions 804, the space of the first cavity 512 becomes smaller, and fluid is flowed into the second cavity 511 from the first cavity 812
In.
In some embodiments, at the side wall 5121 of the opening of the first cavity, there are two corresponding moving elements, such as
Movable card slot 515, the two groove positions are mobilizable, the height of card slot 515 and open 5121 height phase of inner sidewall
Together, in the initial state, card slot 515 is located at 5122 edge of side wall, and a part is located in the second cavity 511.Such as Fig. 4 and Fig. 5 institute
Show that there is the strip 5152 cooperated with the first cavity wall 5122 on card slot 515, the strip 5152 and card slot 515 are that activity connects
It connects, in this way, strip 5152 has field on card slot 515, the end of strip 5152 has dogleg section, in initial bit
When setting, card slot 515 is buckled on the side wall 5122 of the first cavity by this dogleg section.Have in the bottom of card slot 515 recessed
Slot 5153 can make the fluid in the first cavity 512 and the second cavity 511 mutually circulate by the groove 5153.In addition, the card
The top of slot 515 has protrusion 5151, when card slot 515 is located at the initial position 801 of the first cavity 512, protrusion outstanding
5151 are located in the second cavity 511.In some embodiments, when the first cavity 512 and the second cavity 511 rotate, it is located at
Card slot 515 in first cavity 512 follows the first cavity 512 to rotate, when turning to certain position, on card slot 515
Protrusion 5151 touches the inner sidewall of the second cavity 511, and when being further continued for rotation, protrusion 5151 is by 511 inside wall pressure of the second cavity
Compel, since the side wall of the second cavity is fixed, and position of the card slot 515 in the first cavity 512 is moveable, to wrap
Because of the blocking and pressure of 511 inner sidewall of the second cavity, strip 5152 is entirely compressed inwardly card slot 515 containing protrusion 5151,
Dogleg section is detached from the side wall 5122 of the first cavity, and card slot 515 squeezes in the first cavity 512 to moving inside the first cavity 512
Portion space makes its space become smaller.When the first cavity 512 reaches and is located at the second position 802 or the 4th position of the second cavity 511
When 804, at this point, the protrusion 5151 of card slot is sitting at the minor axis of the second cavity 511 of Elliptic Cylinder, at this point, namely card slot
515 are located at 512 deepest inside of the first cavity.In one specific embodiment, at this point, two card slots 515 are by the first cavity 512
Inner space all occupy, i.e., two card slots 515 contact with each other.At this point, the fluid being located in the first cavity 512 passes through first
Groove 5153 on the opening side wall 5121 and card slot of cavity is flowed into the second cavity 511.Then when 512 phase of the first cavity
When rotating again to the second cavity 511, due to the structure of Elliptic Cylinder, protrusion 5151 on card slot by Elliptic Cylinder minor axis
Place is gradually discharged by the inner sidewall of the second cavity to movement at major diameter, that is, protrusion 5151, and card slot 515 is slowly from the first cavity
512 inside pop-ups.When the first cavity 512 turns to the third place 803 or first position 801, i.e., card slot 515 faces second
At the major diameter of the Elliptic Cylinder of cavity 511, card slot 515 is popped up from the first cavity 512 completely, the strip on card slot after pop-up
5152 also restore elasticity automatically, and dogleg section is snapped into again on the inner sidewall 5122 of the first cavity, so that card slot 515 restores
To original position.
It also include third cavity 513, the third cavity 513 and first on the first cavity 512 in one specific embodiment
Cavity 512 connects, also, the first cavity 512 is connected with the inner chamber body of third cavity 513, to guarantee 520 energy of sample collection stick
Enough reached in the first cavity 512 by third cavity 513.As shown in fig. 6, one more specifically in embodiment, third cavity
513 be hollow cylindrical body, is fixedly connected on the first cavity 512.It include symmetrical sheet on the lateral wall of third cavity
Protrusion 5131, more specifically, 5131 position of protrusion of third cavity are corresponding on the unopened side wall 5122 of the first cavity
Side, as shown in Figure 6.In one embodiment, third cavity 513 is similarly positioned in the second cavity 512, also, in third cavity 513
In the space formed with the second cavity 511, a seal 5132 is also laid.The one side of the seal 5132 is by that can poke
Aluminium foil is constituted.Fluid reagent is sealed in seal.In one specific embodiment, which is buffer solution.
When the first cavity 512 rotates in the second cavity 511, the third cavity 513 on the first cavity 512 is fixed on the first chamber
Body 512 rotates in the second cavity 511, and third cavity 513 is in the second for turning to the second cavity 511 by first position 801
During setting 802, the sheet protrusion 5131 on third cavity can be touched in rotation and because of pressure extrusion seal 5132
Aluminium foil be flowed into the buffer solution in seal 5132 in second cavity 511 to poke aluminium foil.Further,
At the same time, the fluid in the first cavity 512 is flowed into the second cavity 511 because of the extruding of card slot, the fluid and buffer
Solution mixes in the second cavity 511.
In some embodiments, which further includes sample collection stick 520, as shown in fig. 7, the sample collection stick 520 includes
It is affectedly bashful portion 521, collects the connecting rod 523 for absorbing carrier 522 and connect the two of sample.In actual operation, by sample
The carrier 522 for collecting stick, which is put into the oral cavity for need tester, collects sample, and then, the collection stick 520 for collecting full sample is put
Enter to third cavity 513 and is entirely located in the carrier 522 for collecting stick in the first cavity 512.Some more specific implementations
In mode, sample collection stick 520 is combined closely with third cavity 513, also, sample collection stick 520 and third cavity 513 and the
One cavity 512 rotates in the second cavity 511 together.As shown in Figure 6 and Figure 7, portion 521 is affectedly bashful with recessed in sample collection stick
Slot 524, and have matched protrusion 5133 on the inner sidewall of third cavity 513, when sample collection stick 520 is inserted into third
513 and first in cavity 512 after, groove 524 is mutually clamped with raised 5133, and sample collection stick 520 is made to be fixed on third chamber
In body 513 and the first cavity 512.When the first cavity 512 turns to the second position 802 by first position 801 or the third place 803
Or when four positions 804, that is, sample collection stick 520 with third cavity 513 and the first cavity 512 together by first position
801 or the third place 803 when turning to the second position 802 or four positions 804, two card slots 515 are in the first cavity 512
It is mobile to the inside of the first cavity 512 under the extruding of two cavitys 511, so that its space is become smaller, is located at the first cavity 512 to squeeze
Interior carrier 522, at this point, collecting on carrier 522 has fluid sample, such as saliva, carrier 522 is extruded compression, is located at carrier
Saliva in 522 is just flowed out from carrier, is flowed by the groove 5153 on the side wall 5121 and card slot of the opening of the first cavity
Enter into the second cavity 511.At the same time, the sheet protrusion due to the rotation of third cavity 513, on third cavity lateral wall
5131 poke the seal 5132 between the second cavity 511 and third cavity 513, and the buffer solution in seal also flows
Enter into the second cavity 511.Buffer solution mixes in the second cavity 511 with saliva.It, will in order to keep the two more fully mixed
Sample collection stick 520 and third cavity 513, the first cavity 512 turn to the by the second position 802 or the 4th position 804 again
One position 801 or the third place 803, the pressure on card slot 515 from 511 side wall of the second cavity disappears at this time, also no longer squeezes
The carrier 522 of sample collection stick, carrier 522 is since elasticity restores original size, so that carrier 522 makes two card slots 515 by the
It is displaced outwardly inside one cavity 512, so that the space of the first cavity 512 is restored size, also, be located in the second cavity 511
Mixed liquor absorbed by carrier 522, be flowed into the first cavity 512 from the second cavity 511.
In another specific embodiment, which is changed including test chamber 530, as shown in Fig. 1, Fig. 3 and Fig. 8.Test chamber
530 are made of upper cavity 531 and lower chamber 532, can place testing element among two cavitys.On upper cavity 531, tool
There is protrusion 533, which is used to cooperate with 511 bottom of the second cavity, and the fluid in the second cavity 511 is made to be flowed into detection
In chamber 530.Specifically, there is a hole in 511 bottom of the second cavity, gasket 518 is located at the sealing of the hole hole Shang Bingshi.Test chamber
Protrusion 533 can poke gasket 518 on 530.In addition, the sample that the protrusion 533 corresponds to testing element in test chamber 530 receives
Region.Protrusion 533 be it is hollow, have an aperture on 533 tops of protrusion, when the bottom that protrusion 533 is inserted into the second cavity 511
Afterwards, the mixed liquor in the second cavity 511 by protrusion 533 aperture be flowed into inside hollow protrusion 533, and then be flowed into and
In the corresponding test chamber 530 of protrusion.
A complete operating process is described with regard to the device of the invention 500 below.As shown in Figure 1, Figure 2 and Figure 3, cuboid
First cavity 512 of shape is fixed together with cylindrical third cavity 513, and two card slots 515 are located at the first cavity
At open side wall 5121, the bending part of two strips 5152 on each card slot 515 is fastened on the side wall 5122 of the first cavity
Place, as shown in Figure 11 sectional view, wherein 5151 part of protrusion of card slot is located at open 5121 top of side wall, the groove of card slot
5153 are located at the bottom of open side wall 5121.The bottom of first cavity 512 is located at the bottom of the second cavity 511, the second cavity
One trumpet type groove is arranged at 511 bottom, facilitates the rotation of the first cavity 512 inside it.It is one at the osculum of loudspeaker
Circular hole, has a rubber washer 518 on circular hole, and 518 diameter of washer is identical with Circularhole diameter or slightly larger than Circularhole diameter, with
Seal circular hole.There is symmetrical sheet protrusion 5131 on third cavity 513, as shown in Figure 3 and Figure 6, sheet protrusion 5131 is 4
Piece, 2, every side, the protrusion 5131 are located at 5122 top of side wall of the first cavity.At the accent of third cavity 513, it is connected with
Seal washer 516 has the upper cover 517 closely sealed with the second cavity 511, in this way, third cavity 513 and first on washer 516
Cavity 512 is sealed in the second cavity 511, can not be leaked with guaranteeing to be located at the intracorporal fluid of these chambers.Certainly, second
It further include the seal 5132 with buffer solution, the seal 5132 between cavity 511 and third cavity 513
In the side without sheet protrusion of third cavity 513, namely at the major diameter of the second cavity 511.Also, seal 5132 has
There is the one side for the aluminium foil that can be poked facing to third cavity 513.As shown in Figure 3 and Figure 7, sample collection stick 520 is affectedly bashful portion 521
Shape with the ellipse that the upper cover 517 with the second cavity matches.
Firstly, operator hold sample collection stick be affectedly bashful portion 521, the carrier 522 for collecting stick is partially placed into and needs to examine
It in the mouth of survey person, sucks 1-5 minutes, makes to absorb carrier 522 full of saliva sample.Then, by the carrier end of sample collection stick 520
It is inserted perpendicularly into apparatus of the present invention downward, at this point, the carrier 522 for collecting stick is located in two card slots 515 of the first cavity 512
Between, as shown in figure 11, the groove 524 collected in the connecting rod 523 of stick engages with the protrusion 5133 of 513 inside of third cavity, makes
Stick 520 is collected to be fixed together with third cavity 513 and the first cavity 512.Also, that collects stick is affectedly bashful portion 521 and second
The upper cover 517 of cavity is fully integrated together, as shown in Figure 10.Sample collection stick 520 and third cavity 513 and first at this time
Cavity 512 is located at the first position 801 of the second cavity 511, i.e. initial position, state is as shown in Figure 10 and Figure 11.
Then, that pins sample collection stick 520 is affectedly bashful position 521, as shown in figure 9, rotation sample collection stick 520 is by first
Position 801 to the second position 802.In the course of rotation, the protrusion 5151 of card slot 515 touches the inside of the second cavity 511
Wall is simultaneously gradually squeezed by the inner sidewall of the second cavity 511,5152 quilt of strip after pressure reaches a certain level, on card slot 515
Retraction is squeezed, then card slot 515 is to moving inside the first cavity 512.The compressing of card slot 515 moved inward is located at the first cavity
The absorption carrier 522 of sample collection stick 520 in 512.Saliva sample on carrier 522 be extruded after from carrier 522
Discharge, is flowed into the first cavity 512, and is flowed into the by the groove 5153 of the opening side wall 5121 of the first cavity and card slot
In two cavitys 511.When sample collection stick 520 turns to the second position 802 of the second cavity 511, as shown in figure 12, sample is received
Collect the upper cover 517 for being affectedly bashful portion 521 and the second cavity 511 of stick into plumbness.At this point, card slot 515 is because being located at the second cavity 511
At diameter most short (at minor axis), the pressure that is subject to is maximum, card slot 515 completely into the first cavity 512 inside, carrier 522 is pressed
It is reduced to minimum.Saliva sample on carrier 522 is discharged completely and flows ultimately into the second cavity 511.Such as Figure 13 sectional view
Shown, the strip 5152 of card slot 515 is located in card slot 515 at this time, and two card slots 515 are fully located in the first cavity 512.Together
When, during sample collection stick 520 turns to the second position 802 of the second cavity 511, third cavity 513 is equally
It is rotated in two cavitys 511, so that the seal 5132 being located at 511 major diameter of the second cavity touches the piece on third cavity 513
Shape protrusion 5131, because of the limitation in space, sheet protrusion 5131 squeezes the aluminium foil part of seal 5132 and is poked.Seal
Buffer solution in 5132 passes through the aluminium foil opening outflow being punctured, and finally flows into the second cavity 511, and from the first cavity
The saliva sample mixing being flowed into 512 in second cavity 511.
In order to make saliva sample and buffer solution mix sample collection stick 520 abundant, then that the second position 802 will be located at
The third place 803 is turned to, as shown in Figure 9.At this point, sample collection stick 520 and the state of the second cavity 511 are as shown in Figure 10.
In the course of rotation, the card slot 515 in the first cavity 512 gradually leaves the minor axis of the second cavity 511, moves to major diameter direction
Dynamic, 511 inner sidewall bring pressure of the second cavity is gradually reduced, and the protrusion of card slot is also gradually released, correspondingly, card slot 515
The pressure for being applied to absorption carrier 522 also gradually reduces.Carrier 522 after losing pressure gradually restores former because of the elasticity of itself
The size come.With the reinstatement of carrier 522, card slot 515 is oppressed to the external mobile of the first cavity 512, when card slot moves
Move its strip 5152 bending part reach the first cavity side wall 5122 it is outer when, strip 5152 restore elasticity, from card slot 515
It pops up and its bending part is engaged on side wall 5122, card slot 515 is fixed, as shown in figure 11.At this point, in the second cavity 511
Mixed liquor liquid level it is higher, more than the bottom of the first cavity 512, and carrier 522 has very strong because of the reason of restoring to the original state
Adsorption capacity, therefore the fluid-mixing in the second cavity 511 passes through the opening side wall 5121 of the first cavity and the groove of card slot
5153 the first cavitys 512 of inflow are simultaneously absorbed by carrier 522.Mixed liquor after being absorbed by carrier 522 carries out sufficiently in carrier 522
Mixing.
Collection well 520 is rotated again, it is made to reach the 4th position 804 from present the third place 803, at this point, the
The card slot 515 of one cavity 512 is turned to as the second position 802 with sample collection stick 520 before by first position 801, finally
It is all moved in the first cavity 512, squeezes carrier 522, the mixed liquor on carrier 522 is discharged all and is flowed into the second chamber
In body 511.
In some more specific modes, it can also allow and the device of the invention is connected in a test chamber 530, carry out
Detection.It specifically, will be at the sample reception zone position of the corresponding test chamber 530 of the gasket 518 of the bottom of the second cavity 511
At protrusion 533.The protrusion 533 is inner hollow, the sample region of acceptance phase of hollow part and 530 close beta element of test chamber
Connection.On the top of protrusion 533, there is an aperture, which is connected to the hollow space of protrusion 533.Protrusion in test chamber
533 gaskets 518 for poking the second cavity enter in the second cavity 511, well-mixed mixed liquor in the second cavity 511
It is flowed on the testing element of test chamber 530 by the aperture of protrusion 533, corresponding detection is completed by testing element.
Claims (12)
1. a kind of device for collecting fluid sample, including the first cavity and the second cavity, wherein the first cavity is located at the second cavity
Interior, and the first cavity is connected with the second cavity fluid, first cavity and the relative rotation of the second cavity make fluid the
It is flowed between one cavity and the second cavity, the first cavity has first position and the second position in the second cavity；
First cavity further includes two symmetrical moving elements, and the wire length of any two points is a and b in the second cavity,
Wherein a is greater than b, and the sum of the distance between length of moving element itself and moving element are c, and wherein c is greater than b.
2. the apparatus according to claim 1, which is characterized in that the first cavity is connected by the side wall of opening with the second cavity
It is logical；First cavity further includes two symmetrical moving elements, when the first cavity turns to the second position by first position,
First cavity drives moving element to cause the space of first cavity to become smaller into the first cavity by opening.
3. device according to claim 1 or 2, which is characterized in that include convex with the cooperation of the second cavity on moving element
It rises, when the first cavity and the rotation of the second cavity, the inner wall of the second cavity pushes protrusion to make moving element to the first inside cavity
It is mobile.
4. device according to claim 1 or 2, which is characterized in that moving element includes that fluid is allowed to flow into from the first cavity
The channel of second cavity.
5. device described in one of -2 according to claim 1, which is characterized in that can be also used for receiving in the first cavity and collect
There is the carrier that can be compressed of fluid sample, compression carrier when moving element enters the first cavity.
6. device according to claim 5, which is characterized in that the device further includes sample collection stick, and collecting stick includes institute
State the carrier that can be compressed.
7. device according to claim 6, which is characterized in that the sample collection stick and the first cavity cooperate, and drive the
One cavity rotates in the second cavity.
8. the apparatus according to claim 1, which is characterized in that the device further includes the seal equipped with buffer solution, should
Seal is located in the first cavity, and the seal is punctured when moving element enters the first cavity.
9. device according to claim 8, which is characterized in that the device further includes the third being fixedly connected with the first cavity
Cavity, the seal include the puncturing elements of protrusion between the second cavity and third cavity, in third chamber outer wall.
10. device according to claim 9, which is characterized in that when the first cavity turns to the second position by first position
When, puncturing elements puncture the seal between the second cavity and third cavity.
11. the apparatus according to claim 1, which is characterized in that the device further includes the detection for accommodating testing element
Chamber, the test chamber and the second cavity configured in fluid communication.
12. device according to claim 1 or 2, which is characterized in that when moving element is in first position, activity
Element is in the second cavity on the line length a of any two points, when moving element is in the second position, moving element
On line length b in any two points in the second cavity.
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| CN201610101022.6A CN105748108B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
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| CN201210409899.3A CN103776660B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
| CN201610101022.6A CN105748108B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
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| CN201210409899.3A Division CN103776660B (en) | 2012-10-24 | 2012-10-24 | A kind of device |
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| CN105748108B true CN105748108B (en) | 2019-04-05 |
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| CN112472140A (en) | 2020-05-11 | 2021-03-12 | 中山大学达安基因股份有限公司 | Storage tube for sampling swab |
| WO2023029054A1 (en) * | 2021-09-06 | 2023-03-09 | 皮乐迪有限公司 | Acquisition assembly |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823273A (en) * | 2003-07-11 | 2006-08-23 | 香港澳维有限公司 | Compact analyte testing cassette with true positive and negative analyte controls |
| CN101498655A (en) * | 2005-10-25 | 2009-08-05 | 艾康生物技术(杭州)有限公司 | Detecting instrument for liquid sample |
| CN101961520A (en) * | 2009-07-21 | 2011-02-02 | 崇仁(厦门)医疗器械有限公司 | Water collecting bottle |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BR112012021202B1 (en) * | 2010-02-23 | 2020-06-09 | Genturadx Usa Inc | apparatus and methods for integrated sample preparation, reaction and detection |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823273A (en) * | 2003-07-11 | 2006-08-23 | 香港澳维有限公司 | Compact analyte testing cassette with true positive and negative analyte controls |
| CN101498655A (en) * | 2005-10-25 | 2009-08-05 | 艾康生物技术(杭州)有限公司 | Detecting instrument for liquid sample |
| CN101961520A (en) * | 2009-07-21 | 2011-02-02 | 崇仁(厦门)医疗器械有限公司 | Water collecting bottle |
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