CN105727132A - Traditional Chinese medicine eye drops for treating eye inflammation and preparation method thereof - Google Patents
Traditional Chinese medicine eye drops for treating eye inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the medicine field, relates to traditional Chinese medicine eye drops for treating eye inflammation and a preparation method thereof, and more specifically to traditional Chinese medicine eye drops for treating ophthalmic diseases of viral keratitis, viral conjunctivitis, and acute and chronic conjunctivitis and a preparation method thereof. The traditional Chinese medicine eye drops for treating eye inflammation comprises the following medicament components, by weight, 20-30 parts of caulis dendrobii, 10-20 parts of radix trichosanthis, 10-20 parts of radix isatidis, 10-20 parts of fructus forsythia, 20-30 parts of pearl powder, 5-8 parts of radix et rhizoma salviae miltiorrhizae, 10-15 parts of flos lonicerae japonicae, 10-20 parts of cassia seed, 5-8 parts of herba menthae, 3-5 parts of Radix Rehmanniae Recens, 2-3 parts of radix polygalae, 2-3 parts of Fructus Ammomi Rotundus, 0.1-1 part of vitamin B1 and 0.1-1 part of vitamin B12. The traditional Chinese medicine eye drops for treating eye inflammation and the preparation method thereof have the advantages that the used traditional Chinese medicines accord with standards of Pharmacopoeia of the People's Republic of China, and the medicines are safe and reliable. The medicines accord with each other in properties, have the anti-inflammatory and antiallergic efficacy, nourish the cornea tip trigeminal nerve, and have the characteristics of definite therapeutic effect, fast effectiveness, and high cure rate without side-effect.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of traditional Chinese medicine eye drops treating eye inflammation and preparation method thereof, be specifically related to a kind of treat traditional Chinese medicine eye drops of ophthalmic diseases such as viral keratitis, viral binding film is scorching, acute and chronic binding film is scorching and preparation method thereof.
Background technology
Viral keratitis, conjunctivitis are a kind of common ophthalmic diseasess, multiple virus cause, and infectiousness is extremely strong, it is easy to concurrent infection other diseases.Viral keratitis is the inflammation caused by viral pathogenesis original sense dye cornea.Cornea shallow-layer has abundant nervi trigeminus tip, therefore this disease often has obvious irritation, has photophobia, sheds tears, aches.This genus of cornea is transparent, once ill, then its transparency changes, and there is blurred vision in the normal main suit of patient.This disease is general falls ill along nervi trigeminus, and diseased region is invaded relatively deep, and it feels to go down, but because of the adjacent tissue of inflammatory stimulus keratopathy, therefore irritation is still more apparent.Viral keratitis, the course of disease herds length, more after and easily recur.Often can react with tunica uvea, iridocyclitis, hypopyon or secondary glaucoma even occur, be one of relatively conventional clinically diseases causing blindness.About there is symptom after the incubation period of 5～12 days in viral conjunctivitis, including conjunctival congestion, watery secretion, Ocular irritation and on WA palpebra inferior cling.There is symptom in normal eyes, and a usual lore starts.Many patients once contacted conjunctivitis person and/or suffered from respiratory tract infection person recently.Bulbar conjunctiva and palpebral conjunctiva are congested, and conjunctival follicle, preauricular lymph nodes enlargement and pain occurs in palpebral conjunctiva.Modal viral keratitis, conjunctivitis mainly have herpes simplex, herpes zoster, epidemic keratitis and conjunctivitis etc. clinically.
Herpes simplex keratitis, is modal viral keratitis, and its sickness rate is higher.Due to its have easy recurrence, protracted course of disease, to clinical characters such as Drug therapy opposings, be main diseases causing blindness, it has also become current ophthalmologists feels one of thorny oculopathy most.
Summary of the invention
According to above the deficiencies in the prior art, the present invention provides a kind of traditional Chinese medicine eye drops treating eye inflammation and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.
A kind of traditional Chinese medicine eye drops treating eye inflammation of the present invention, according to parts by weight meter, including following ingredient: Herba Dendrobii 20～30 parts, Radix Trichosanthis 10～20 parts, Radix Isatidis 10～20 parts, Fructus Forsythiae 10～20 parts, Margarita powder 20～30 parts, Radix Salviae Miltiorrhizae 5～8 parts, Flos Lonicerae 10～15 parts, Semen Cassiae 10～20 parts, Herba Menthae 5～8 parts, 3～5 parts of the Radix Rehmanniae, Radix Polygalae 2～3 parts, Fructus Amomi Rotundus 2～3 parts, vitamin B10.1～1 part and vitamin B120.1～1 part.
Wherein, it is preferable that scheme is as follows:
According to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Radix Trichosanthis 15 parts, Radix Isatidis 15 parts, Fructus Forsythiae 15 parts, Margarita powder 25 parts, Radix Salviae Miltiorrhizae 6 parts, Flos Lonicerae 12 parts, Semen Cassiae 15 parts, Herba Menthae 6 parts, 4 parts of the Radix Rehmanniae, Radix Polygalae 2 parts, Fructus Amomi Rotundus 2 parts, vitamin B11 part and vitamin B121 part.
The preparation method of the traditional Chinese medicine eye drops for the treatment of eye inflammation of the present invention, during preparation, carries out according to following steps:
(1) first Herba Dendrobii, Radix Trichosanthis, Radix Isatidis, Fructus Forsythiae, Margarita powder, Radix Salviae Miltiorrhizae, Flos Lonicerae, Semen Cassiae, Herba Menthae, the Radix Rehmanniae, Radix Polygalae, Fructus Amomi Rotundus being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；
(2) residue adds water 5000 milliliters, and slow fire takes filtrate after boiling 1 hour, twice filtrate is merged；
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin B12Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 1000～5000 milliliters；
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
During use, every day 3～5 times, each 1～2.
Pharmacology analysis:
Herba Dendrobii: for Chinese medicine, derives from the orchid family Herba Dendrobii, belongs to the stem of Dendrobium various plants, cold nature.Effect reinforcing stomach reg fluid, clearing away heat and nourishing YIN, cure mainly consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, that the moon hinders order is dark.Containing multiple alkaloid, polysaccharide, aminoacid and starch etc. in stem of Dendrobium, there is certain antipyretic effect；Gastric secretion can be promoted, aid digestion；There are enhancing metabolism, the anti-ageing effect of waiting for a long time.The traditional Chinese medical science is thought, the vital essence of the vital organs of the human body is all passed through to note in eyes on blood vessels, and liver " having one's ideas straightened out in order ", the physiological and pathological of eyes and the cloudy essence of liver fill whether contain in close relations.The cloudy essence of liver fills Sheng, then eye is fair bright and eagle-eyed, rotates flexibly, and full of vigor, people also seems hale and hearty；If cloudy insufficiency of essence, eye is fine will be intense darkness without light, or two are dry and astringent, or blurring of vision, or nyctalopia etc..Radix Stephaniae Tetrandrae has the function of YIN nourishing nourishing the liver, therefore is used as the good merchantable brand of eye-protecting by ancient Chinese medicine doctor.
Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature, attaches to the lung and stomach meridians；Concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, clearing away lung-heat and moistening for dryness, removing toxicity for eliminating carbuncles etc..It is hot and suffocating that Radix Trichosanthis moves back the five internal organs, and as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, spleen-fire is contained and dispute tooth swells, phlegm-fire is contained and is coughed not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle are not burst, and pyretic toxicity does not dissipate, or five types of jaundice yellow skin and eye, and if if little water drenches puckery, be caused by all burning hot pent-up, only this agent energy relieving stagnation, drop phlegm-fire, and can be controlled it.Its property is sweet cold again, kind can control thirsty, controls from tonic empty thirsty, controls fire from the medicine of a cold nature thirsty, controls from gas medicine and strongly fragrant yearningly controls excessive thirst from blood medicine, is control thirsty key medicine also.
Radix Isatidis: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Maculae caused by violent heat pathogen；High heat headache；Major part pestilence；Crimson tongue is purple dark, scarlet fever；Erysipelas；Mumps；Sore throat；Skin ulcer is swollen, carbuncle；Chickenpox；Measles；Hepatitis；Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash etc.；Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis etc. can be prevented and treated.Various bacteria is had inhibitory action by Radix Isatidis, and bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Freund) bacillus, bacillus enteritidis etc. are had inhibitory action in various degree by infusion；Acetone leachate also has similar effect, and to Hemolytic streptococcus effectively (all by agar aperture flat band method).The bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae is similar.Infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibiting effect, and in vitro leptospiral effect killed by Radix Isatidis.
Fructus Forsythiae: main containing compounds such as phenethyl alcohol glycosides, lignan and glycoside, pentacyclic triterpene Lou, volatile oils.Pharmacological research think its there is antibacterial, antiinflammatory, antipyretic, town is told, diuresis heart tonifying, anti-liver damage, analgesia, suppresses the effects such as phosphodiesterase, antiviral, blood pressure lowering, suppression elastin laminin enzyme activity, antiendotoxin.Except fruit medicine, have heat-clearing and toxic substances removing, disappear outside the effect tying evacuation of pus, its leaf medicinal, the effects such as treatment hypertension, dysentery, throat pain is better.
Margarita powder: Margarita powder has the effect of heat-clearing and toxic substances removing, it is possible to clearing away liver-fire.The liver being in charge of the eyes, the raw nebula of hot-tempered then order, blurred vision.Finding through research, the selenium in Margarita powder can strengthen the conduction of optic nerve, improves eyesight status simultaneously；Zinc in trace element can promote the axonal transport of optic nerve, improves metabolism and the function of retina and retinal pigment epithelium.The Pharmacopoeia of the People's Republic of China describes: " Margarita has the function of improving eyesight removing nebula, cures mainly the raw nebula of order ", so Margarita powder is become " ophthalmology panacea " by a lot of scholar.
Radix Salviae Miltiorrhizae: containing TANSHINONES, for robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, for gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.Treatment coronary heart disease there is good result.In addition also controlling the weak insomnia of nerve, arthralgia, anemia, mastitis, lymphadenitis, arthritis, furuncle pain is swollen, erysipelas, acute, chronic hepatitis, nephropyelitis, traumatic injury, and advanced schistosomiasis hepatosplenomegaly is insane.External can wash again dermatitis rhus.
Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss.
Semen Cassiae: have the function of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Raw Semen Cassiae is longer than removing heat from the liver, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.
Herba Menthae: children's tender stem point can make vegetable edible, and herb can be used as medicine again, cure cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, and the diseases such as skin rubella is scratched where it itches, measles without adequate eruption are also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.
The Radix Rehmanniae: have anastalsis, has again blood coagulation resisting function, also has antifungic action, and the growth of the multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore tinea bacterium and Du big belly microspore tinea bacterium difficult to understand is had inhibitory action.
Radix Polygalae: bitter, pungent, warm.GUIXIN, kidney, lung meridian.Nourish heart blood, relieving convulsion, mind calming, dissipates sputum.Treating five types of epilepsy opisthotonus, frightened jerk, mouth is spat saliva, and brothers' war is shaken, syncope, and urine reducing controls reddish and whitish turbid urine, stranguria marked by chyluria, and spermatorrhea be can't help.
Fructus Amomi Rotundus: acrid in the mouth；Warm in nature.Enter lung, spleen channel.Removing dampness circulation of qi promoting；Warming middle-JIAO to arrest vomiting；Appetite-stimulating indigestion-relieving.Main retention of damp leading to blockage of QI；Incoordination between the spleen and stomach；Distension and fullness in the abdomen；Anorexia；Hygropyrexia from the beginning of；Uncomfortable in chest not hungry；Gastrofrigid vomiting；Food stagnation does not disappear.
Vitamin B1: being primarily present in crust and the plumule of seed, in Testa oryzae and wheat bran, content is very abundant, and in yeast, content is also extremely abundant.In lean meat, Chinese cabbage and Herba Apii graveolentis, content is also abundanter.Presently used vitamin B1All products of chemosynthesis.In vivo, vitamin B1Participate in catabolism of carbohydrate with co-enzyme form, have the neural effect of protection；Enterogastric peristalsis can also be promoted, increase appetite.Vitamin B1It is one of optic nerve and perineural source of nutrition, it is possible to improve ophthalmoplegia, nystagmus and asthenopia.
Vitamin B12: the peripheral nerve of energy nutrition cornea, strengthen the resistance against diseases of cornea peripheral nerve, promote the rehabilitation of the state of an illness.
It is an advantage of the current invention that the medicine used meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and there is antiinflammatory antiallergic, the trifacial effect of nutrition cornea tip, the feature such as there is determined curative effect, instant effect, cure rate is high, have no side effect.
Outcome measure:
1 clinical data
1.1 physical data treatment group 80 example herpes simplex keratitis patients are responsible for observing treatment (totally 96 eyes), wherein male 52 examples, female 28 example by special messenger in outpatient service；5～73 years old age；The course of disease 2～26 days, average 16.3 ± 6.36 days, 62 eyes of 96 eye middle-shallow layer herpes simplex keratitises, 34 eyes of Deep Stromal herpetic Keratitis.
1.2 Syndrome Differentiation of Traditional Chinese Medicines
1.2.1 shallow-layer herpes simplex keratitis (attacking type outside wind heat) patient have headache, shed tears, generate heat, the symptom such as aversion to wind, red tongue, yellow and thin fur, floating and rapid pulse.Pathological changes be limited only to epithelium or involve cornea before 1/3 hypothallus.
1.2.2 Deep Stromal herpetic Keratitis (in liver-fire vehement type) patient has symptom, red tongue, yellow and greasy fur, slippery and rapid pulse or the stringy and rapid pulse such as feeling of fullness in the head, conjunctival congestion, the vexed discomfort of rib.Pathological changes is as deep as cornea 1/2 hypothallus or descemet's membrane and endodermis, including ground pattern corneal ulcer, disciform keratitis and cornea uveitis.
1.2.3 convalescent period herpes simplex keratitis (lack of lung-YIN type) patient have that order is puckery, the look thing mixed dark symptoms such as weak, night sweat of accompanying, red tongue, few tongue thready and rapid pulse.In the pathological changes later stage, the state of an illness tends to stable, and corneal infiltration is clearly better Restoration stage.
2 Therapeutic Method
Every day 3～5 times, each 1～2.20 days courses for the treatment of, treat two courses for the treatment of.
2.1.6 1. criterion of therapeutical effect cures: shallow-layer herpes simplex keratitis is ulcer healing, and focal zone fluorescence rope is painted transfers feminine gender to；Deep Stromal herpetic Keratitis and convalescent period herpes simplex keratitis are except above-mentioned standard, in slit lamp tangent plane, hypothallus infiltration, edema disappear, do not thicken, descemet's membrane gauffer and aqueous flare disappear and 2. take a turn for the better: shallow-layer herpes simplex keratitis is the healing of ulcer part, focus reduces, and remains a little fluorescein colored spots.Deep layer and convalescent period herpes simplex keratitis are except above-mentioned standard, and in slit lamp tangent plane, hypothallus infiltration, edema alleviate, and corneal thickness is close to normal 3. invalid: the state of an illness is without changing or increasing the weight of.
3 therapeutic outcomes.
Three groups of cases are treated all with 20 days for 1 course for the treatment of, statistical result after two courses for the treatment of.Treatment group total effective rate is 97.50%；Refer to following table.
Model case is introduced
Chen, man, 53 years old, right eye is red, bitterly, shed tears, aversion to wind 3 days.Check right vision 0.3, left vision 1.0, it has been found that cornea of right eye temporo side has shallow-layer branch sample to infiltrate, and fluorescent staining is painted, red tongue, yellow and thin fur, floating and rapid pulse, belong to and attack type outside wind heat.Through eye drops in treatment of the present invention recovery from illness in 38 days.
Wang, female, 32 years old, left eye is red, bitterly, shed tears, aversion to wind, keep in dark place 5 days, accompany eyelid Mild edema.Check right vision 1.0, left vision 0.06, it has been found that there are the pattern infiltration of deep layer ground in cornea of left eye central authorities, and fluorescent staining is painted, red tongue, yellow and greasy fur, slippery and rapid pulse, belongs to vehement type in liver-fire.Within 28 days, it is clearly better through eye drops in treatment of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of traditional Chinese medicine eye drops treating eye inflammation, according to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Radix Trichosanthis 15 parts, Radix Isatidis 15 parts, Fructus Forsythiae 15 parts, Margarita powder 25 parts, Radix Salviae Miltiorrhizae 6 parts, Flos Lonicerae 12 parts, Semen Cassiae 15 parts, Herba Menthae 6 parts, 4 parts of the Radix Rehmanniae, Radix Polygalae 2 parts, Fructus Amomi Rotundus 2 parts, vitamin B11 part and vitamin B121 part.
Embodiment 2:
Embodiment 1 is prepared according to following steps:
(1) first Herba Dendrobii, Radix Trichosanthis, Radix Isatidis, Fructus Forsythiae, Margarita powder, Radix Salviae Miltiorrhizae, Flos Lonicerae, Semen Cassiae, Herba Menthae, the Radix Rehmanniae, Radix Polygalae, Fructus Amomi Rotundus being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；
(2) residue adds water 5000 milliliters, and slow fire takes filtrate after boiling 1 hour, twice filtrate is merged；
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin B12Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 1000～5000 milliliters；
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
Claims (3)
1. the traditional Chinese medicine eye drops treating eye inflammation, it is characterized in that according to parts by weight meter, including following ingredient: Herba Dendrobii 20～30 parts, Radix Trichosanthis 10～20 parts, Radix Isatidis 10～20 parts, Fructus Forsythiae 10～20 parts, Margarita powder 20～30 parts, Radix Salviae Miltiorrhizae 5～8 parts, Flos Lonicerae 10～15 parts, Semen Cassiae 10～20 parts, Herba Menthae 5～8 parts, 3～5 parts of the Radix Rehmanniae, Radix Polygalae 2～3 parts, Fructus Amomi Rotundus 2～3 parts, vitamin B10.1～1 part and vitamin B120.1～1 part.
2. a kind of traditional Chinese medicine eye drops treating eye inflammation according to claim 1, it is characterized in that according to parts by weight meter, including following ingredient: Herba Dendrobii 25 parts, Radix Trichosanthis 15 parts, Radix Isatidis 15 parts, Fructus Forsythiae 15 parts, Margarita powder 25 parts, Radix Salviae Miltiorrhizae 6 parts, Flos Lonicerae 12 parts, Semen Cassiae 15 parts, Herba Menthae 6 parts, 4 parts of the Radix Rehmanniae, Radix Polygalae 2 parts, Fructus Amomi Rotundus 2 parts, vitamin B11 part and vitamin B121 part.
3. the preparation method of the traditional Chinese medicine eye drops of the treatment eye inflammation described in a claim 1, it is characterised in that during preparation, carry out according to following steps:
(1) first Herba Dendrobii, Radix Trichosanthis, Radix Isatidis, Fructus Forsythiae, Margarita powder, Radix Salviae Miltiorrhizae, Flos Lonicerae, Semen Cassiae, Herba Menthae, the Radix Rehmanniae, Radix Polygalae, Fructus Amomi Rotundus being added water 5000 milliliters, slow fire boils 1 hour, takes filtrate；
(2) residue adds water 5000 milliliters, and slow fire takes filtrate after boiling 1 hour, twice filtrate is merged；
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, after placing 24 hours, use filter paper filtering；
(4), after filtrate being waved to the greatest extent or reclaiming ethanol, vitamin B is added1And vitamin B12Powder, stirs evenly and adds distilled water again and obtain medicinal liquid to 1000～5000 milliliters；
(5) adjust medicinal liquid and be equivalent to the osmotic pressure of the sodium chloride that mass fraction is 0.8～1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%；
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
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| CN115475213A (en) * | 2022-09-27 | 2022-12-16 | 云南耀康中医药科技有限公司 | Traditional Chinese medicine preparation for eyes and preparation method thereof |
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| CN115475213A (en) * | 2022-09-27 | 2022-12-16 | 云南耀康中医药科技有限公司 | Traditional Chinese medicine preparation for eyes and preparation method thereof |
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