CN105727072A - Chinese herbal medicine for treating endocrine dyscrasia and its preparation method - Google Patents
Chinese herbal medicine for treating endocrine dyscrasia and its preparation method Download PDFInfo
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Abstract
Disclosed are Chinese herbal medicine for treating endocrine dyscrasia and its preparation method.The Chinese herbal medicine comprises, by weight, 50-80 parts of astragalus membranaceus, 30-50 parts of radix aucklandiae, 25-40 parts of radix bupleuri, 15-30 parts of semen coicis, 15-30 parts of polygala tenuifolia, 15-30 parts of radix dipsaci, 30-50 parts of dandelion, 20-40 parts of leonurus, 20-50 parts of red-rooted salvia, 10-20 parts of oyster, 20-40 parts of rhizome of rehmannia, and 15-25 parts of seaweed.The Chinese herbal medicine is prepared by alcohol extraction, boiling and mixing.Through clinical practice, total efficiency is up to 94%, and the Chinese herbal medicine has excellent effect and no adverse effect, toxic and side effect.The Chinese herbal medicine for treating endocrine dyscrasia has excellent curative effect and high popularization value.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of treat endocrine disturbance Chinese medicine composition
Thing and preparation method thereof.
Background technology
Endocrine be responsible in animal body two big control systems of various physiological function normal operations it
One, it is made up of the duct free body of gland (endocrine gland) of secreting hormone (hormone).Under normal circumstances
Various hormones are to maintain balance, as broken because certain reason makes this balance (certain hormonosis or
Very few) this results in endocrine disturbance, can cause corresponding clinical manifestation.Masculinity and femininity all may go out
Existing endocrine disturbance.Common are 1, skin deteriorates: occur in that suddenly a lot of macula lutea, complexion on skin
Obfuscation, mottle, smeared many cosmetics the most of no avail, and this is more than skin problem only in fact,
Caused by extraneous factor pessimal stimulation again when these mottles are also endocrine instability；2, short-tempered:
Often there are some situations short-tempered, that emotion changes is bigger in climacteric women, perspiration, spleen occurs
Gas degenerates, and this is probably female incretion function and gets muddled and cause；3, gynaecopathia: in gynecological
Secretion disease is the most common, the disease that menstrual blood volume is irregular, dysmenorrhea, menoxenia etc. are all gynecological endocrine,
Also having some mastopathy also relevant with endocrine disturbance, some facial colour spot is also due to endocrine disturbance
Cause.Along with the life stress of modern constantly increases, endocrine disturbance personnel become in rising the most year by year
Gesture, at present the method for the treatment of endocrine disturbance has self regulation, Chinese traditional treatment, a western medical treatment, but from
I regulates because patient's Endocrine mastery of knowledge degree differs, and most people can not be conditioned；Doctor trained in Western medicine is not for
The cause of disease, symptom and body constitution together, the order of severity, have different countermeasures, mainly symptomatic treatment,
But the drug side effect that doctor trained in Western medicine is used is relatively big, and is to cure the symptoms, not the disease；Currently used treatment by Chinese herbs endocrine
Lacking of proper care the most more, but effect is slow, medicine time is long.
In order to solve the problems referred to above, the present inventor have developed the Chinese medicine composition of a kind of new treatment endocrine disturbance
Thing and preparation method.
Summary of the invention
It is an object of the invention to provide a kind of treat endocrine disturbance Chinese medicine composition.
It is a further object of the present invention to provide the preparation side of a kind of Chinese medicine composition treating endocrine disturbance
Method.
It is a further object of the present invention to provide above-mentioned Chinese medicine composition caused by preparation treatment endocrine disturbance
Menoxenia, the on the face application in the medicine of mottle, temper impetuousness, night sweat.
The present invention provides a kind of Chinese medicine composition treating endocrine disturbance, and this Chinese medicine composition is by following heavy
The Chinese medicine of amount part is made: Radix Astragali 50-80 part, Radix Aucklandiae 30-50 part, Radix Bupleuri 25-40 part, Semen Coicis 15-30
Part, Radix Polygalae 15-30 part, Radix Dipsaci 15-30 part, Herba Taraxaci 30-50 part, Herba Leonuri 20-40 part, pellet
Ginseng 20-50 part, Concha Ostreae 10-20 part, Radix Rehmanniae 20-40 part, Sargassum 15-25 part.
Preferably, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Astragali 55-75 part, the Radix Aucklandiae
35-45 part, Radix Bupleuri 28-38 part, Semen Coicis 18-28 part, Radix Polygalae 18-28 part, Radix Dipsaci 18-28 part,
Herba Taraxaci 35-45 part, Herba Leonuri 25-35 part, Radix Salviae Miltiorrhizae 25-45 part, Concha Ostreae 12-18 part, Radix Rehmanniae 25-35
Part, Sargassum 18-22 part.
It is further preferred that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Astragali 58-72 part,
Radix Aucklandiae 38-42 part, Radix Bupleuri 30-36 part, Semen Coicis 20-26 part, Radix Polygalae 20-26 part, Radix Dipsaci 20-26
Part, Herba Taraxaci 38-42 part, Herba Leonuri 28-32 part, Radix Salviae Miltiorrhizae 28-40 part, Concha Ostreae 14-16 part, life
Ground 28-32 part, Sargassum 19-21 part.
It is further preferred that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: the Radix Astragali 65 parts, wood
Fragrant 40 parts, Radix Bupleuri 33 parts, Semen Coicis 23 parts, Radix Polygalae 23 parts, Radix Dipsaci 23 parts, Herba Taraxaci 40 parts,
Herba Leonuri 30 parts, Radix Salviae Miltiorrhizae 35 parts, Concha Ostreae 15 parts, 30 parts of the Radix Rehmanniae, Sargassum 20 parts.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
The Chinese medicine composition that the present invention provides is possibly together with pharmaceutically acceptable carrier or diluent.
Described Chinese medicine composition is solid preparation or liquid preparation, described solid preparation be tablet, capsule,
Granule or pill；Described liquid preparation is oral liquid.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, are selected from
One or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, micro-
Crystalline cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low replacement
Hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, cunning
Stone powder or magnesium stearate；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, polyoxyethylene one polyoxypropylene altogether
Polymers, fatty acid Pyrusussuriensis be smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method of described Chinese medicine composition comprises the following steps: the Radix Astragali, the Radix Aucklandiae, Radix Bupleuri, Semen Coicis,
Radix Polygalae, Radix Dipsaci, Herba Taraxaci, Herba Leonuri, Radix Salviae Miltiorrhizae, Concha Ostreae, the Radix Rehmanniae, Sargassum pulverize and sieve, with pharmacy
Upper acceptable carrier or diluent mix homogeneously, be prepared as preparation.
The preparation method of described Chinese medicine composition comprises the following steps:
1) various medical material is weighed by proportioning standby；
2) Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae are pulverized, add the ethanol leaching of the 60-90% of 10-20 times
Steep 3-6 hour, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder,
Standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 3-8 times of soak by water
2-5 time, each 0.5-3 hour, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes thin
Powder or impalpable powder, standby；
4) Concha Ostreae is pulverized, add soak with ethanol 6-16 hour of the 60-90% of 10-20 times, filter, filter
Liquid concentrate drying, pulverizes, and crosses 80-300 mesh, makes fine powder or impalpable powder, standby；Filtering residue adds water 2-5
Decocting 2-5 time again, each 0.5-3 hour, filter, filtrate concentrates, dry, crosses 80-300 mesh,
Make fine powder or impalpable powder, standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, technique is made pharmaceutically routinely
Acceptable dosage form.
Preferably, the preparation method of described Chinese medicine composition comprises the following steps:
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, technique is made pharmaceutically routinely
Acceptable dosage form.
The Chinese medicine composition of the treatment endocrine disturbance that the present invention provides has the advantage that
Test group treatment endocrine disturbance 210 example, patient mainly show as menstruation irregularis, temper impetuous,
The intensely dark pool of night sweat, skin, lax, corse sweat pore, face have in a large number or do not meet the age in flakes
Mottle.Reaching 94% by treatment total effective rate, effect is obvious, and does not finds that untoward reaction is secondary with poison
Effect, illustrates that traditional Chinese medicine composition for treating endocrine disturbance of the present invention is evident in efficacy, has good promotional value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: the Radix Astragali 50 parts, the Radix Aucklandiae 30 parts, Radix Bupleuri 25 parts, Semen Coicis 15 parts, Radix Polygalae 15 parts,
Radix Dipsaci 15 parts, Herba Taraxaci 30 parts, Herba Leonuri 20 parts, Radix Salviae Miltiorrhizae 20 parts, Concha Ostreae 10 parts, the Radix Rehmanniae 20
Part, Sargassum 15 parts.
Preparation method:
1) various medical material is weighed by proportioning standby；
2) Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae are pulverized, add 10 times 60% soak with ethanol 3 hours,
Filter, filtrate concentrate drying, pulverize, cross 80 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 3 times of soak by water 2
Secondary, each 0.5 hour, to filter, filtrate concentrates, and is dried, and crosses 80 mesh, makes fine powder or impalpable powder,
Standby；
4) Concha Ostreae is pulverized, add 10 times 60% soak with ethanol 6 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 2 times and decocts 2 times, often
Secondary 0.5 hour, filtering, filtrate concentrates, and is dried, and crosses 80 mesh, makes fine powder or impalpable powder, standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add and account for mix homogeneously fine powder weight
The starch of amount 2/5, loads capsule, makes capsule.
Specification: every dress 0.35g.
Embodiment 2
Prescription: the Radix Astragali 80 parts, the Radix Aucklandiae 50 parts, Radix Bupleuri 40 parts, Semen Coicis 30 parts, Radix Polygalae 30 parts,
Radix Dipsaci 30 parts, Herba Taraxaci 50 parts, Herba Leonuri 40 parts, Radix Salviae Miltiorrhizae 50 parts, Concha Ostreae-20 parts, the Radix Rehmanniae 40
Part, Sargassum 25 parts.
Preparation method:
1) various medical material is weighed by proportioning standby；
2) Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae are pulverized, add 20 times 90% soak with ethanol 6 hours,
Filter, filtrate concentrate drying, pulverize, cross 300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 8 times of soak by water 5
Secondary, each 3 hours, to filter, filtrate concentrates, and is dried, and crosses 300 mesh, makes fine powder or impalpable powder,
Standby；
4) Concha Ostreae is pulverized, add 20 times 90% soak with ethanol 16 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 5 times and decocts 5 times,
Each 3 hours, filtering, filtrate concentrates, and is dried, and crosses 300 mesh, makes fine powder or impalpable powder, standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add that to account for mix homogeneously thin
The starch of grain weight amount 2/5, loads capsule, makes capsule.
Specification: every dress 0.35g.
Embodiment 3
Prescription: the Radix Astragali 55 parts, the Radix Aucklandiae 35 parts, Radix Bupleuri 28 parts, Semen Coicis 18 parts, Radix Polygalae 18 parts,
Radix Dipsaci 18 parts, Herba Taraxaci 35 parts, Herba Leonuri 25 parts, Radix Salviae Miltiorrhizae 25 parts, Concha Ostreae 12 parts, the Radix Rehmanniae 25
Part, Sargassum 18 parts.
Preparation method:
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder, standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add and account for mix homogeneously fine powder weight
The starch of amount 1/5, is dried, tabletting, obtains the tablet of the application.
Specification: every 0.35g.
Embodiment 4
Prescription: the Radix Astragali 75 parts, the Radix Aucklandiae 45 parts, Radix Bupleuri 38 parts, Semen Coicis 28 parts, Radix Polygalae 28 parts,
Radix Dipsaci 8 parts, Herba Taraxaci 45 parts, Herba Leonuri 35 parts, Radix Salviae Miltiorrhizae 45 parts, Concha Ostreae 18 parts, 35 parts of the Radix Rehmanniae,
Sargassum 22 parts.
Preparation method:
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add and account for mix homogeneously fine powder weight
The starch of amount 1/5, mixing, pelletize, be dried, granulate, obtain the granule of the application.
Specification: every packed 0.35g.
Embodiment 5
Prescription: the Radix Astragali 58 parts, the Radix Aucklandiae 38 parts, Radix Bupleuri 30 parts, Semen Coicis 20 parts, Radix Polygalae 20 parts,
Radix Dipsaci 20 parts, Herba Taraxaci 38 parts, Herba Leonuri 28 parts, Radix Salviae Miltiorrhizae 28 parts, Concha Ostreae 14 parts, the Radix Rehmanniae 28
Part, Sargassum 19 parts.
Preparation method
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add 3 times amount aquesterilisa, mistake
Filter, adds the aspartame accounting for filtrate 1/8, perfusion, gland, sterilizing, obtains the oral liquid of the application.
Specification: every bottle of 5ml.
Embodiment 6
Prescription: the Radix Astragali 72 parts, the Radix Aucklandiae 42 parts, Radix Bupleuri 36 parts, Semen Coicis 26 parts, Radix Polygalae 26 parts,
Radix Dipsaci 26 parts, Herba Taraxaci 42 parts, Herba Leonuri 32 parts, Radix Salviae Miltiorrhizae 40 parts, Concha Ostreae 16 parts, the Radix Rehmanniae 32
Part, Sargassum 21 parts.
Preparation method
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add and account for mix homogeneously fine powder weight
The dextrin of amount 1/16, mixing, pill, it is dried, obtains the micropill of the application.
Specification: every packed 0.35g.
Embodiment 7
Prescription: the Radix Astragali 65 parts, the Radix Aucklandiae 40 parts, Radix Bupleuri 33 parts, Semen Coicis 23 parts, Radix Polygalae 23 parts,
Radix Dipsaci 23 parts, Herba Taraxaci 40 parts, Herba Leonuri 30 parts, Radix Salviae Miltiorrhizae 35 parts, Concha Ostreae 15 parts, the Radix Rehmanniae 30
Part, Sargassum 20 parts.
Preparation method:
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, add and account for mix homogeneously fine powder weight
The vegetable oil mixing of amount 1/10, obtains the soft capsule of the application.
Specification: every dress 0.35g.
The beneficial effect of of the present invention medicine is expanded on further below by way of clinical case.
Clinical trial
1, case source
Randomly selecting 210 female incretion patients to test from the People's Hospital of Changyi City, the age exists
Between 30-55 year, sick time is between 1-8, and average 4.7 years, patient clinical symptom was: the moon
Through irregular, temper is impetuous, the intensely dark pool of night sweat, skin, lax, corse sweat pore, face have greatly
Measure or do not meet in flakes the mottle at age.
2, Therapeutic Method
Above-mentioned patient is equally divided into 7 groups, there was no significant difference between each group, by these 7 groups of patients respectively
Take the medicine of embodiment of the present invention 1-7, three times a day, take 3 weeks continuously.
3, criterion of therapeutical effect
Effective: each clinical symptoms such as menstruation irregularis, temper impetuousness, night sweat are wholly absent or substantially disappear
Losing, endocrine recovers normal；
Effective: each clinical symptoms such as menstruation irregularis, temper impetuousness, night sweat take an evident turn for the better, endocrine
Imbalance makes moderate progress；
Invalid: endocrine disturbance, each clinical symptoms are without improving.
4, experimental result
Most patients is using medicine within about 1 week, to have significantly sensation, spleen according to the inventive method
Gas improves, and without night sweat, pigmentation lighter, minority speckle disappears or diminishes, and skin color improves,
Health is improved.According to statistics, 210 example patients effect after using medicine of the present invention 3 weeks is shown in Table 1,
And be difficult to recur:
Table 1 curative effect statistical table
| Group | Taking dose | Clinical recovery | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 2 tablets/time | 10 | 4 | 15 | 1 | 30 | 96% |
| Embodiment 2 | 2 tablets/time | 8 | 4 | 16 | 2 | 30 | 93% |
| Embodiment 3 | 2 pieces/times | 9 | 5 | 14 | 2 | 30 | 93% |
| Embodiment 4 | 2 bags/time | 11 | 6 | 13 | 1 | 30 | 96% |
| Embodiment 5 | 1 bottle/time | 8 | 5 | 15 | 2 | 30 | 93% |
| Embodiment 6 | 2 bags/time | 10 | 5 | 14 | 1 | 30 | 93% |
| Embodiment 7 | 2 tablets/time | 9 | 6 | 14 | 1 | 30 | 96% |
Test group treatment endocrine disturbance 210 example, total effective rate reaches 94%, and effect is obvious, and does not sends out
Existing untoward reaction and toxic and side effects, illustrate that traditional Chinese medicine composition for treating endocrine disturbance of the present invention is evident in efficacy,
There is good promotional value.
Although, used general explanation, detailed description of the invention and test, the present invention made
Detailed description, but on the basis of the present invention, it can be made some amendments or improve, this is to ability
It is apparent from for field technique personnel.Therefore, done without departing from theon the basis of the spirit of the present invention
These modifications or improvements, belong to the scope of protection of present invention.
Claims (10)
1. the Chinese medicine composition treating endocrine disturbance, it is characterised in that this Chinese medicine composition by with
The Chinese medicine of lower weight portion is made: Radix Astragali 50-80 part, Radix Aucklandiae 30-50 part, Radix Bupleuri 25-40 part, Semen Coicis
Core 15-30 part, Radix Polygalae 15-30 part, Radix Dipsaci 15-30 part, Herba Taraxaci 30-50 part, Herba Leonuri 20-40
Part, Radix Salviae Miltiorrhizae 20-50 part, Concha Ostreae 10-20 part, Radix Rehmanniae 20-40 part, Sargassum 15-25 part.
Chinese medicine composition the most according to claim 1, it is characterised in that this Chinese medicine composition by with
The Chinese medicine of lower weight portion is made: Radix Astragali 55-75 part, Radix Aucklandiae 35-45 part, Radix Bupleuri 28-38 part, Semen Coicis
Core 18-28 part, Radix Polygalae 18-28 part, Radix Dipsaci 18-28 part, Herba Taraxaci 35-45 part, Herba Leonuri 25-35
Part, Radix Salviae Miltiorrhizae 25-45 part, Concha Ostreae 12-18 part, Radix Rehmanniae 25-35 part, Sargassum 18-22 part.
Chinese medicine composition the most according to claim 2, it is characterised in that this Chinese medicine composition by with
The Chinese medicine of lower weight portion is made: Radix Astragali 58-72 part, Radix Aucklandiae 38-42 part, Radix Bupleuri 30-36 part, Semen Coicis
Core 20-26 part, Radix Polygalae 20-26 part, Radix Dipsaci 20-26 part, Herba Taraxaci 38-42 part, Herba Leonuri 28-32
Part, Radix Salviae Miltiorrhizae 28-40 part, Concha Ostreae 14-16 part, Radix Rehmanniae 28-32 part, Sargassum 19-21 part.
Chinese medicine composition the most according to claim 3, it is characterised in that this Chinese medicine composition by with
The Chinese medicine of lower weight portion is made: the Radix Astragali 65 parts, the Radix Aucklandiae 40 parts, Radix Bupleuri 33 parts, Semen Coicis 23 parts,
Radix Polygalae 23 parts, Radix Dipsaci 23 parts, Herba Taraxaci 40 parts, Herba Leonuri 30 parts, Radix Salviae Miltiorrhizae 35 parts, Concha Ostreae 15
Part, 30 parts of the Radix Rehmanniae, Sargassum 20 parts.
5. according to the Chinese medicine composition described in any one of claim 1-4, it is characterised in that this Chinese drug-treated group
Compound is possibly together with pharmaceutically acceptable carrier or diluent.
Chinese medicine composition the most according to claim 5, it is characterised in that described Chinese medicine composition is
Solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；Described
Liquid preparation is oral liquid.
7. the method for the Chinese medicine composition prepared described in any one of claim 1-4, it is characterised in that
The method comprises the following steps: the Radix Astragali, the Radix Aucklandiae, Radix Bupleuri, Semen Coicis, Radix Polygalae, Radix Dipsaci, Herba Taraxaci,
Herba Leonuri, Radix Salviae Miltiorrhizae, Concha Ostreae, the Radix Rehmanniae, Sargassum pulverize and sieve, with pharmaceutically acceptable carrier or dilution
Agent mix homogeneously, is prepared as preparation.
8. the method for the Chinese medicine composition prepared described in any one of claim 1-4, it is characterised in that
The method comprises the following steps:
1) various medical material is weighed by proportioning standby；
2) Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae are pulverized, add the ethanol leaching of the 60-90% of 10-20 times
Steep 3-6 hour, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder,
Standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 3-8 times of soak by water
2-5 time, each 0.5-3 hour, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes thin
Powder or impalpable powder, standby；
4) Concha Ostreae is pulverized, add soak with ethanol 6-16 hour of the 60-90% of 10-20 times, filter, filter
Liquid concentrate drying, pulverizes, and crosses 80-300 mesh, makes fine powder or impalpable powder, standby；Filtering residue adds water 2-5
Decocting 2-5 time again, each 0.5-3 hour, filter, filtrate concentrates, dry, crosses 80-300 mesh,
Make fine powder or impalpable powder, standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, technique is made pharmaceutically routinely
Acceptable dosage form.
The method of Chinese medicine composition the most according to claim 8, it is characterised in that the method includes
Following steps:
1) various medical material is weighed by proportioning standby；
2) by the Radix Astragali, Semen Coicis, Radix Polygalae, Radix Salviae Miltiorrhizae pulverize, add 15 times 75% soak with ethanol 5 little
Time, filter, filtrate concentrate drying, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；
3) Radix Aucklandiae, Radix Bupleuri, Radix Dipsaci, the Radix Rehmanniae, Sargassum, Herba Taraxaci, Herba Leonuri are added 5 times of soak by water 3
Secondary, each 2 hours, to filter, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or superfine
Powder, standby；
4) Concha Ostreae is pulverized, add 15 times 75% soak with ethanol 10 hours, filter, filtrate concentrates dry
Dry, pulverize, cross 80-300 mesh, make fine powder or impalpable powder, standby；Filtering residue adds water 3 times and decocts 3 times,
Each 2 hours, filtering, filtrate concentrates, and is dried, and crosses 80-300 mesh, makes fine powder or impalpable powder,
Standby；
5) by 2), 3), 4) fine powder of step or impalpable powder mixing, technique is made pharmaceutically routinely
Acceptable dosage form.
10. the Chinese medicine composition described in any one of claim 1-4 is caused by preparation treatment endocrine disturbance
Menoxenia, mottle, temper is impetuous on the face, application in the medicine of night sweat.
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| CN1153655A (en) * | 1996-08-19 | 1997-07-09 | 侯永康 | Chinese medicine prepn for balancing internal secretion |
| CN1362251A (en) * | 2001-12-31 | 2002-08-07 | 向芙戊 | Orally taken Chinese medicine for treating endocrine dyscrasia |
| CN1490037A (en) * | 2003-08-08 | 2004-04-21 | 扬 余 | Chinese medicine for treating endocrinopathy |
| CN102370877A (en) * | 2010-08-19 | 2012-03-14 | 高英豪 | Traditional Chinese medicinal composition for treating endocrine dyscrasia |
| CN103386008A (en) * | 2013-07-24 | 2013-11-13 | 赵世明 | Chinese medicine composition for treating endocrine dyscrasia |
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2016
- 2016-03-11 CN CN201610148323.4A patent/CN105727072A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153655A (en) * | 1996-08-19 | 1997-07-09 | 侯永康 | Chinese medicine prepn for balancing internal secretion |
| CN1362251A (en) * | 2001-12-31 | 2002-08-07 | 向芙戊 | Orally taken Chinese medicine for treating endocrine dyscrasia |
| CN1490037A (en) * | 2003-08-08 | 2004-04-21 | 扬 余 | Chinese medicine for treating endocrinopathy |
| CN102370877A (en) * | 2010-08-19 | 2012-03-14 | 高英豪 | Traditional Chinese medicinal composition for treating endocrine dyscrasia |
| CN103386008A (en) * | 2013-07-24 | 2013-11-13 | 赵世明 | Chinese medicine composition for treating endocrine dyscrasia |
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