CN105727031A - 一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方 - Google Patents
一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方 Download PDFInfo
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Abstract
本发明涉及中药汤剂领域,公开了一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,通过对中药的合理配伍,选择了全瓜蒌、浙贝母、木蝴蝶、芦根、清水半夏、陈皮、枳壳、桔梗、白术、茯苓,制成汤药,具有宽胸理气、化痰散结、止咳平喘的功效,用于治疗慢性阻塞性肺病,有利于患者在出院之后居家治疗,实用方便。并且中药汤剂较西药具有对身体多方面进行调理的作用,在治疗的同时进行身体保健,减少复发的几率。
Description
技术领域
本发明涉及中药汤剂领域,特别是一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方。
背景技术
慢性阻塞性肺疾病是一种气流受限疾病,气流受限不完全可逆,呈进行性发展,与肺部对有害气体或有害颗粒的异常炎症反应有关,是一种破坏性的肺部疾病。防治此病重点在于阻止症状的发展和疾病反复发作、加重,改善和提高生活质量,阻断向其肺心病演变。然而迄今国内外尚无有效的治疗方法。现代医学以大剂量使用抗生素、皮质激素和支气管舒张剂为主,虽能改善肺功能,延缓病情发展,但有出现真菌感染、肠道功能失调等多种并发症。中医中药的应用可减少抗生素和激素的使用,减轻发作症状,减少发作次数。
中医理论将本病归属于“肺胀”的范畴。基本病机是肺脏反复受邪,气机阻闭。宣降失司,痰浊内阻,肺气壅滞,气道不畅。久而不愈,伤损肺气,使其生理功能减退,肺叶胀满不能收敛。临床以咳、喘、痰、胀为4大主证。其病位在肺,继则涉及脾肾。如《黄帝内经》所云的“肺不伤不咳,脾不伤不久咳,肾不伤不咳喘”。此病的发生,衡冲主任医师多认为是多因肺气虚弱为本,夹有痰浊潴留,每因感受外邪而发作。病理演变复杂,其病理因素主要为痰浊壅塞,气机失常,痰气交阻。痰的产生,病初由肺气郁闭,气不布津;病进则“子盗母气”致脾失健运,津液不归正化而成痰,日久逐渐发展成为肺虚不能化津,脾虚不能转输,肾虚不能蒸化,痰浊潴留,喘咳持续不已。肺胀迁延不愈,反复加重,肺气阻滞,宣降失常,必会影响肺助心行血的作用,而发生痰瘀阻滞证,使气机更加壅塞不畅。正如《证治汇补·咳嗽》曰:“肺胀者,动则喘满,气急息重,或左或右,不得眠者是也。如痰加淤血碍气,宜养血以流动乎气-降火以清利其痰”。可见痰浊阻塞,气机失常是肺胀的重要病理因素。故方中用全瓜蒌、浙贝母、木蝴蝶、芦根清热化痰散结,宽胸理气;桔梗、枳壳,一升一降,桔梗宣肺,既可宣散壅塞之肺气,又可载药上行到肺,且枳壳行气宽中与白术配伍,取枳术丸之意,健脾消痞,升清降浊,陈皮、茯苓、清水半夏、炒白术、健脾益气化痰,以绝生痰之源,全瓜蒌、炒白术、枳壳配伍可通腑泄热,使邪有出路。肺与大肠相表里,肺气壅塞,腑气不通,则气短喘咳不止,若腑气通,肺气宣发,则咳喘自平。
发明内容
本发明的目的在于提供一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,可用于治疗慢性阻塞性肺病,有利于患者在出院之后居家治疗,实用方便。
为实现上述技术目的,达到上述技术效果,本发明公开了一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,配方由下列原料按重量份组成:
全瓜蒌15g、桔梗15g、木蝴蝶15g、茯苓15g、白术15g、芦根12g、桔梗12g、陈皮12g、清水半夏10g、浙贝母各10g,生甘草10g。
优选的,还包括葶苈子、苏子,葶苈子15-10g,苏子15-10g。
优选的,还包括天竺黄、地龙,天竺黄15-10g,地龙15-10g。
优选的,还包括僵蚕、莱菔子,僵蚕15-10g,莱菔子15-10g,生甘草全部替换为炙甘草。
优选的,还包括太子参、黄芪,太子参15-10g,黄芪15-10g,清水半夏替换为半夏曲。
优选的,还包括补骨脂、五味子、菟丝子,补骨脂15-10g,五味子15-10g,菟丝子15-10g。
本发明具有以下有益效果:
1.本发明通过对中药的合理配伍,制成汤药,具有宽胸理气、化痰散结、止咳平喘的功效,用于治疗慢性阻塞性肺病,有利于患者在出院之后居家治疗,实用方便。
2.本发明使用中药汤剂较西药具有对身体多方面进行调理的作用,在治疗的同时进行身体保健,减少复发的几率。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合实施例,对本发明进行进一步详细说明。
实施例1
本发明公开了一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,配方由下列原料按重量份组成:
全瓜蒌15g、桔梗15g、木蝴蝶15g、茯苓15g、白术15g、芦根12g、桔梗12g、陈皮12g、清水半夏10g、浙贝母各10g,生甘草10g。
当病人出现痰涎雍盛的病症时,在上述配方中增补葶苈子15-10g,苏子15-10g;
当病人出现痰热甚夹血瘀的病症时,在上述配方中增补天竺黄15-10g,地龙15-10g;
当病人出现气喘的病症时,在上述配方中增补僵蚕15-10g,莱菔子15-10g,将生甘草全部替换为炙甘草;
当病人出现肺脾气虚的病症时,在上述配方中增补太子参15-10g,黄芪15-10g,将清水半夏替换为半夏曲;
当病人出现肾气虚夜尿频多、气不接续的病症时,在上述配方中增补补骨脂15-10g,五味子15-10g,菟丝子15-10g。
实施例2
实验目的及方法:为了验证本发明的有效性和可行性,本实施例以某医院慢性阻塞性肺病住院患者进行相关实验,其中患者总数为74人,分为治疗组38人和对照组36人,其中病患住院期间每天一剂,每日三次口服,10天为一疗程。2组均按慢阻肺治疗,做痰细菌培养选用敏感抗生素、配合静点多索茶碱解痉平喘治疗,必要时吸氧,合并高血压者服用降压药,心衰者静点能量、极化液、口服利尿剂,必要时加用扩血管药及强心药。治疗10天后观察疗效。出院后治疗组间断服用蒌贝枳桔木根汤进行治疗治疗。对照组缓解期不服中药。
判断标准如下所示:
通过观察患者症状(咳嗽、咯痰、胸闷、气喘、气短、口干、发热、腹胀、纳差等)和体征(肺部干湿啰音及哮鸣音)及实验室检查等来综合判断疗效。参照《中药新药临床研究指导原则(试行)》中的计分法,以积分变化分析临床疗效。将发热、痰的量色质、咳嗽分为4级,各计0、2、3、4分;将气喘、口干、肺部啰音分为3级,各计0、1、2分;将x线改变、痰液病原学检查分为2级,各计0、2分;有舌脉异常者计为1分。计算治疗后的症状总分,求得疗效指数,判定疗效。其计算公式为:疗效指数-(治疗前总分-治疗后总分)/治疗前总分乘以100%。并统计1年内再次住院率。
疗效标准:根据《中药新药临床研究指导原则(试行)》III中有关标准拟定。显效:10天内主要症状体征基本消失,可出院,疗效指数≥70%;有效:10天内症状好转减轻,疗效指数≥30%而<70%;无效:10天内疗效指数<30%,症状体征均无变化或加重。
实验结果:
治疗组显效30例,有效5例,无效3例;对照组显效20例,有效7例,无效9例,治疗组显效率78.9%,明显高于对照组(55.6%),差异有显著性,P<0.05;治疗组与对照组总有效率分别是92.1%和75%,有显著性差异,P<0.05。
两组主要症状和体征疗效比较:表一式,经X2检验,两组在咳嗽咳痰、气喘、腹胀纳差、发热、胸闷方面的改善差异有显著性(P<0.05),但在干湿啰音方面改善差异无显著性(P>0.05)。1年内再次住院率:1年内再次住院者治疗组为8例(21.1%),对照组为16例(44.4%)。两组再次住院率有显著性差异,P<0.05。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到的变化或替换,都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于,所述的配方由下列原料按重量份组成:
全瓜蒌15g、桔梗15g、木蝴蝶15g、茯苓15g、白术15g、芦根12g、桔梗12g、陈皮12g、清水半夏10g、浙贝母各10g,生甘草10g。
2.如权利要求1所述的一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于:还包括葶苈子、苏子,所述的葶苈子15-10g,所述的苏子15-10g。
3.如权利要求1所述的一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于:还包括天竺黄、地龙,所述的天竺黄15-10g,所述的地龙15-10g。
4.如权利要求1所述的一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于:还包括僵蚕、莱菔子,所述的僵蚕15-10g,所述的莱菔子15-10g,所述的生甘草全部替换为炙甘草。
5.如权利要求1所述的一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于:还包括太子参、黄芪,所述的太子参15-10g,所述的黄芪15-10g,所述的清水半夏替换为半夏曲。
6.如权利要求1所述的一种治疗慢性阻塞性肺病的蒌贝枳桔木根汤的配方,其特征在于:还包括补骨脂、五味子、菟丝子,所述的补骨脂15-10g,所述的五味子15-10g,所述的菟丝子15-10g。
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