CN105727000B - 中药组合物及在椎动脉型颈椎病治疗中的应用 - Google Patents
中药组合物及在椎动脉型颈椎病治疗中的应用 Download PDFInfo
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Abstract
本发明公开了一种中药组合物及在治疗椎动脉型颈椎病中的应用,由下列质量份的原料药组成:天麻10‑80份,川芎10‑50份,菊花10‑80份,柴胡10‑50份,磁石10‑60份,赭石10‑60份,薄荷10‑30份,细辛5‑20份,冰片10‑40份,藁本10‑50份,白芍10‑50份,羌活10‑50份,白芷10‑30份,可被制成任何一种常用内服剂型。本发明药物具有散寒疏风、活血化瘀等作用,能够有效解除或缓解椎动脉痉挛,增加血管壁弹性,从而改善椎‑基底动脉血液循环,消除症状。
Description
技术领域
本发明属于中药领域,更加具体地说,涉及一种中药组合物,尤其涉及一种中药组合物及在椎动脉型颈椎病治疗中的应用。
背景技术
颈椎病是临床常见病,是由于颈椎退行性改变而影响脊髓、脊神经根、交感神经和椎支脉等结构,使椎间盘变性,髓核破裂突出及椎体后缘骨刺形成刺激,压迫神经根、椎动脉和脊髓等组织,产生水肿粘连、韧带肥厚变性、钙化等病理改变,而出现一系列临床症状。
椎动脉型颈椎病属于祖国医学的“骨痹”、“颈筋急”等范畴。从中医的病因、病机理论来看,肝肾阴虚、气血不足、经脉受损、外邪侵入等,是颈椎病发病的主要原因。对于本病的治疗,目前主要有手术治疗和保守治疗两种方法。由于手术治疗有严格的适应症和禁忌症,并且手术治疗有一定的风险和创伤性,术后容易出现并发症,且手术费用较高。故一般以保守治疗为主。
现代医学常采取口服抗动脉硬化药,血管扩张药物,应用颈围固定、牵引等非手术疗法治疗本病,虽有一定疗效,但由于疗法对疾病的治疗不全面,远期效果不佳,复发率较高等。中医治疗椎动脉型颈椎病具有疗效确切,简便易行,副作用小,易于被大多数患者接受。
发明内容
本发明的目的在于提供一种中药组合物及在椎动脉型颈椎病治疗中的应用,该药物具有副作用小,服用方便,成分简单、疗效突出等优点。
因此,本发明的技术方案如下:
一种药物组合物,所述药物组合物(即治疗椎动脉型颈椎病的药物)由下列质量份的原料药组成:
天麻10-80份,川芎10-50份,菊花10-80份,柴胡10-50份,磁石10-60份,赭石10-60份,薄荷10-30份,细辛5-20份,冰片10-40份,藁本10-50份,白芍10-50份,羌活10-50份,白芷10-30份。
其中,各个组份的质量份优选如下:
(1)天麻10-30份,川芎10-20份,菊花10-30份,柴胡10-15份,磁石10-20份,赭石10-20份,薄荷10-15份,细辛5-10份,冰片10-20份,藁本10-20份,白芍10-20份,羌活10-20份,白芷10-15份;
(2)天麻30-50份,川芎20-30份,菊花30-50份,柴胡15-25份,磁石20-35份,赭石20-30份,薄荷15-20份,细辛10-15份,冰片20-30份,藁本20-30份,白芍20-30份,羌活20-30份,白芷15-20份;
(3)天麻50-70份,川芎30-40份,菊花50-70份,柴胡25-35份,磁石35-45份,赭石30-40份,薄荷20-25份,细辛15-18份,冰片30-35份,藁本30-40份,白芍30-40份,羌活30-40份,白芷20-25份;
(4)天麻70-80份,川芎40-50份,菊花70-80份,柴胡35-50份,磁石45-60份,赭石40-60份,薄荷25-30份,细辛18-20份,冰片35-40份,藁本40-50份,白芍40-50份,羌活40-50份,白芷25-30份。
在本发明的上述中药组合物中,选择性低将天麻、川芎、菊花、柴胡、磁石、赭石、薄荷、细辛、冰片、藁本、白芍、羌活和白芷进行组合,将这些药物组合使得各个药物功效产生协同作用,从而能够有效治疗椎动脉型颈椎病。其中选用天麻是因为天麻息风,定惊。其中选用川芎是因为川芎行气开郁,法风燥湿,活血止痛。其中选用菊花是因为菊花具有平肝明目、散风清热、消咳止痛的功效。其中选用柴胡是因为柴胡解表退热;疏肝解郁,升举阳气。其中选用磁石是因为磁石潜阳纳气,镇惊安神。其中选用赭石是因为赭石镇逆、化痰、平肝、止血。其中选用薄荷是因为薄荷宣散风热。其中选用细辛是因为细辛祛风,散寒,行水,开窍。其中选用藁本是因为藁本祛风散寒,除湿止痛。其中选用白芍是因为白芍养血敛阴,柔肝止痛,平肝阳。其中选用羌活是因为羌活具有发散风寒,胜湿止疼等功效。其中选用白芷是因为白芷祛风湿,活血排脓,生肌止痛。上述十三味药彼此协同产生作用,共同使其产生针对椎动脉型颈椎病的治疗效果。
利用上述的中药组合物可进一步得到治疗椎动脉型颈椎病的药物,由下列质量份的原料药制成:
天麻10-80份,川芎10-50份,菊花10-80份,柴胡10-50份,磁石10-60份,赭石10-60份,薄荷10-30份,细辛5-20份,冰片10-40份,藁本10-50份,白芍10-50份,羌活10-50份,白芷10-30份。
其中,各个组份的质量份优选如下:
(1)天麻10-30份,川芎10-20份,菊花10-30份,柴胡10-15份,磁石10-20份,赭石10-20份,薄荷10-15份,细辛5-10份,冰片10-20份,藁本10-20份,白芍10-20份,羌活10-20份,白芷10-15份;
(2)天麻30-50份,川芎20-30份,菊花30-50份,柴胡15-25份,磁石20-35份,赭石20-30份,薄荷15-20份,细辛10-15份,冰片20-30份,藁本20-30份,白芍20-30份,羌活20-30份,白芷15-20份;
(3)天麻50-70份,川芎30-40份,菊花50-70份,柴胡25-35份,磁石35-45份,赭石30-40份,薄荷20-25份,细辛15-18份,冰片30-35份,藁本30-40份,白芍30-40份,羌活30-40份,白芷20-25份;
(4)天麻70-80份,川芎40-50份,菊花70-80份,柴胡35-50份,磁石45-60份,赭石40-60份,薄荷25-30份,细辛18-20份,冰片35-40份,藁本40-50份,白芍40-50份,羌活40-50份,白芷25-30份。
本发明药物选择采用中药制剂的常规方法制备成任何常规内服制剂,例如将上述原料药粉碎成粉末后混合均匀,加水煎服;将上述原料药一起加水煎后进行浓缩,以得到本发明药物的活性组分,再加入制备不同剂型时所需要的各种常规辅料,例如崩解剂、粘合剂等(淀粉、糊精、羧甲基纤维素钠等),以常规的中药制剂方法制备成任何一种常规口服剂型,例如片剂、胶囊剂、丸剂、口服液等。
优选的是,本发明药物活性组分的制备方法如下:
步骤1,按照所述质量份配比称取白芷,加入白芷质量3倍—20倍的水,并在水中加入浓度为0.0025-0.025mol/L的NaOH溶液将整个体系的pH调节至9-10,浸泡12-36小时后过滤,得到白芷提取液α,白芷滤渣备用;在白芷滤渣中加入白芷质量3倍—20倍的水,在水中加入浓度为0.0025-0.025mol/L的NaOH溶液并将整个体系的pH调节至9-10,浸泡6-18小时后过滤,得到白芷提取液β;将白芷提取液α和白芷提取液β均匀混合,得到白芷混合溶液,用稀盐酸将白芷混合溶液的pH调至7-7.5,并将所述白芷混合溶液升温浓缩至所述白芷混合溶液原体积的0.25-0.5倍,得到白芷提取液λ;
在所述步骤1之前,进行粉碎以使原料药成粉末状,过3-50目筛。
步骤2,制作白芍提取液:按照所述质量份配比称取白芍,加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡12-36小时后过滤,得到白芍提取液α,白芍滤渣备用;在所述白芍滤渣中加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡6-18小时后过滤,得到白芍提取液β;将白芍提取液α和白芍提取液β均匀混合,得到白芍混合溶液,将该白芍混合溶液升温浓缩至所述白芍混合溶液原体积的0.1-0.25倍,得到白芍提取液λ,其中,在乙醇水溶液中乙醇的浓度为50-95wt%;
步骤3,按照所述质量份配比称取剩余各个原料药,并加入剩余各个原料药质量和3倍—20倍的水进行浸泡,浸泡5-10小时后,于100-120℃煎煮10-20分钟,自然冷却至室温20-25℃,加入步骤1所得白芷提取液λ和步骤2所得白芍提取液λ,加热至沸腾后,回流,得到提取液A,进行减压浓缩即可。
在所述步骤3中,进行回流的时间至少为1小时,优选为1.5-3小时。
更加优选的,本发明药物活性组分的制备方法如下:
步骤1,按照所述质量份配比称取白芷,加入白芷质量3倍—20倍的水,并在水中加入浓度为0.0025-0.025mol/L的NaOH溶液将整个体系的pH调节至9-10,浸泡12-36小时后过滤,得到白芷提取液α,白芷滤渣备用;在白芷滤渣中加入白芷质量3倍—20倍的水,在水中加入浓度为0.0025-0.025mol/L的NaOH溶液并将整个体系的pH调节至9-10,浸泡6-18小时后过滤,得到白芷提取液β;将白芷提取液α和白芷提取液β均匀混合,得到白芷混合溶液,用稀盐酸将白芷混合溶液的pH调至7-7.5,并将所述白芷混合溶液升温浓缩至所述白芷混合溶液原体积的0.25-0.5倍,得到白芷提取液λ;
在所述步骤1之前,进行粉碎以使原料药成粉末状,过3-50目筛。
步骤2,制作白芍提取液:按照所述质量份配比称取白芍,加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡12-36小时后过滤,得到白芍提取液α,白芍滤渣备用;在白芍滤渣中加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡6-18小时后过滤,得到白芍提取液β;将白芍提取液α和白芍提取液β均匀混合,得到白芍混合溶液,将该白芍混合溶液升温浓缩至所述白芍混合溶液原体积的0.1-0.25倍,得到白芍提取液λ,其中,在乙醇水溶液中乙醇的浓度为50-95wt%;
步骤3,按照所述质量份配比称取剩余原料药,加入剩余原料药质量和3倍—20倍的水进行浸泡,浸泡5-10小时后,在100-120℃煎煮20-60分钟,自然冷却至室温20-25℃,过滤,得到提取液B,提取液B滤渣备用;
步骤4,在提取液B滤渣中加入剩余原料药质量和7-15倍的水,于100-120℃煎煮20-60分钟,自然冷却至室温20-25℃,得到提取液C;
在所述步骤4中,在提取液B滤渣中加入剩余原料药质量和8-13倍的水,于100-120℃煎煮30-45分钟。
步骤5,将所述白芷提取液λ、白芍提取液λ、提取液B和提取液C均匀混合,煮沸后在40-60℃保温2-3小时,进行减压浓缩即可。
在上述技术方案中,所述剩余原料药为天麻,川芎,菊花,柴胡,磁石,赭石,薄荷,细辛,冰片,藁本,羌活。
如上述本发明的中药组合物、药物及药物活性组分在制备治疗椎动脉型颈椎病药物中的应用。
本发明的优点及有益效果是:
本发明运用中医理论分析处方组成,根据各药味所含成分的理化性质与药理作用的研究结果,研究得到了合理、稳定的活性成分的制备方法;本发明药物具有散寒疏风、活血化瘀等作用,能够有效解除或缓解椎动脉痉挛,增加血管壁弹性,从而改善椎-基底动脉血液循环,消除症状。
具体实施方式
下面结合具体实施例进一步说明本发明的技术方案。
首先按照下述表格所述的原料药质量比进行称量,粉碎(过45目筛)后混合均匀。
按照上述实施例1-9,依照如下方法进行煎服:
步骤1,将上述实施例1-9各个组份的原料药进行粉碎,粉碎后过45目筛。按照上述质量份配比称取白芷,加入白芷质量15倍的水,并在水中加入浓度为0.01mol/L的NaOH溶液将整个体系的pH调节至9.5,浸泡30小时后过滤,得到白芷提取液α,白芷滤渣备用;在白芷滤渣中加入白芷质量10倍的水,在水中加入浓度为0.01mol/L的NaOH溶液并将整个体系的pH调节至9.5,浸泡18小时后过滤,得到白芷提取液β;将白芷提取液α和白芷提取液β均匀混合,得到白芷混合溶液,用稀盐酸将白芷混合溶液的pH调至7,并将所述白芷混合溶液升温浓缩至白芷混合溶液原体积的0.3倍,得到白芷提取液λ;用弱碱性溶液浸泡白芷,可保留白芷天然活性成份,提高人体的吸收率。
步骤2,制作白芍提取液:按照上述质量份配比称取白芍,加入白芍质量15倍的乙醇水溶液进行浸泡,浸泡30小时后过滤,得到白芍提取液α,白芍滤渣备用;在白芍滤渣中加入白芍质量15倍的乙醇水溶液进行浸泡,浸泡18小时后过滤,得到白芍提取液β;将白芍提取液α和白芍提取液β均匀混合,得到白芍混合溶液,将该白芍混合溶液升温浓缩至所述白芍混合溶液原体积的0.15倍,得到白芍提取液λ,其中,在乙醇水溶液中乙醇的浓度为60wt%;
步骤3,按照所述质量份配比称取剩余原料药(天麻,川芎,菊花,柴胡,磁石,赭石,薄荷,细辛,冰片,藁本和羌活),加入剩余原料药质量和15倍的水进行浸泡,浸泡7小时后,在110℃煎煮30分钟,自然冷却至室温20-25℃,过滤,得到提取液B,提取液B滤渣备用;
步骤4,在提取液B滤渣中加入剩余原料药质量和10倍的水,于110℃煎煮30分钟,自然冷却至室温20-25℃,得到提取液C;
步骤5,将白芷提取液λ、白芍提取液λ、提取液B和提取液C均匀混合,煮沸后在50℃保温2.5小时,进行减压浓缩即可,按照一日剂量浓缩至50ml,均分为两份,早晚两次口服(8点和20点)。
按照上述制备方法和原料药配比进行制备得到的浓缩液1-9,进行具体临床试验,在服用时,选择不同患者分别服用浓缩液两个月后进行各项参数的测试,具体临床试验结果如下:
200例患有椎动脉型颈椎病的病人(男、女各100人),其中,小孩为50人,成年人为100位,老年人为50位,服用本发明的中药复方制剂两个月后,195例患者的椎动脉型颈椎病症状明显消失。
以上对本发明做了示例性的描述,应该说明的是,在不脱离本发明的核心的情况下,任何简单的变形、修改或者其他本领域技术人员能够不花费创造性劳动的等同替换均落入本发明的保护范围。
Claims (4)
1.一种治疗椎动脉型颈椎病的药物,其特征在于,由下列质量份的原料药制成:
天麻10-80份,川芎10-50份,菊花10-80份,柴胡10-50份,磁石10-60份,赭石10-60份,薄荷10-30份,细辛5-20份,冰片10-40份,藁本10-50份,白芍10-50份,羌活10-50份,白芷10-30份。
2.根据权利要求1所述的一种治疗椎动脉型颈椎病的药物,其特征在于,各个组份的质量份如下之一:
(1)天麻10-30份,川芎10-20份,菊花10-30份,柴胡10-15份,磁石10-20份,赭石10-20份,薄荷10-15份,细辛5-10份,冰片10-20份,藁本10-20份,白芍10-20份,羌活10-20份,白芷10-15份;
(2)天麻30-50份,川芎20-30份,菊花30-50份,柴胡15-25份,磁石20-35份,赭石20-30份,薄荷15-20份,细辛10-15份,冰片20-30份,藁本20-30份,白芍20-30份,羌活20-30份,白芷15-20份;
(3)天麻50-70份,川芎30-40份,菊花50-70份,柴胡25-35份,磁石35-45份,赭石30-40份,薄荷20-25份,细辛15-18份,冰片30-35份,藁本30-40份,白芍30-40份,羌活30-40份,白芷20-25份;
(4)天麻70-80份,川芎40-50份,菊花70-80份,柴胡35-50份,磁石45-60份,赭石40-60份,薄荷25-30份,细辛18-20份,冰片35-40份,藁本40-50份,白芍40-50份,羌活40-50份,白芷25-30份。
3.根据权利要求1或2所述的药物的制备方法,其特征在于,按照下述步骤进行:
步骤1,按照所述质量份配比称取白芷,加入白芷质量3倍—20倍的水,并在水中加入浓度为0.0025-0.025mol/L的NaOH溶液将整个体系的pH调节至9-10,浸泡12-36小时后过滤,得到白芷提取液α,白芷滤渣备用;在白芷滤渣中加入白芷质量3倍—20倍的水,在水中加入浓度为0.0025-0.025mol/L的NaOH溶液并将整个体系的pH调节至9-10,浸泡6-18小时后过滤,得到白芷提取液β;将白芷提取液α和白芷提取液β均匀混合,得到白芷混合溶液,用稀盐酸将白芷混合溶液的pH调至7-7.5,并将所述白芷混合溶液升温浓缩至所述白芷混合溶液原体积的0.25-0.5倍,得到白芷提取液λ;
步骤2,制作白芍提取液:按照所述质量份配比称取白芍,加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡12-36小时后过滤,得到白芍提取液α,白芍滤渣备用;在所述白芍滤渣中加入白芍质量10倍—20倍的乙醇水溶液进行浸泡,浸泡6-18小时后过滤,得到白芍提取液β;将白芍提取液α和白芍提取液β均匀混合,得到白芍混合溶液,将该白芍混合溶液升温浓缩至所述白芍混合溶液原体积的0.1-0.25倍,得到白芍提取液λ,其中,在乙醇水溶液中乙醇的浓度为50-95wt%;
步骤3,按照所述质量份配比称取剩余各个原料药,并加入剩余各个原料药质量和3倍—20倍的水进行浸泡,浸泡5-10小时后,于100-120℃煎煮10-20分钟,自然冷却至室温20-25℃,加入步骤1所得白芷提取液λ和步骤2所得白芍提取液λ,加热至沸腾后,回流,得到提取液A,进行减压浓缩即可。
4.如权利要求1所述药物、权利要求3的方法制备的药物在制备治疗椎动脉型颈椎病药物中的应用。
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