CN105709195A - Traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis - Google Patents

Traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis Download PDF

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CN105709195A
CN105709195A CN201610174709.2A CN201610174709A CN105709195A CN 105709195 A CN105709195 A CN 105709195A CN 201610174709 A CN201610174709 A CN 201610174709A CN 105709195 A CN105709195 A CN 105709195A
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picc
phlebitis
radix
traditional chinese
chinese medicine
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于向英
于海波
孙心毅
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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Abstract

The invention provides traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis. The traditional Chinese medicine paste is characterized by being prepared from, by weight, 9 g of moutan bark, 12 g of red peony roots, 15 g of the rhizome of chuanxiong, 3 g of herba asari, 6 g of rhizoma zingiberis, 28 g of the root of red-rooted salvia, 12 g of safflowers, 6 g of liquorice roots, 6 g of goldthread roots, 26 g of honeysuckle flowers, 12 g of radix angelica sinensis, 12 g of spreading hedyotis herb and 13 g of barbed skullcap herb; the component medicine is taken according to the weight ratio and ground into superfine powder, the superfine powder is mixed to be uniform, the superfine powder is added to rapeseed oil according to the proportion of 1:(4-5), and the traditional Chinese medicine paste is prepared. The ratio is simple and easy to obtain, and cost is low. The traditional Chinese medicine paste is externally applied, and use is convenient. The treatment effect is good, and no toxic or side effect exists.

Description

A kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically one is prevented and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment.
Background technology
The passage of, safety, Silent Neuritis long-term as one through the central vein catheter (PICC) of peripheral venous catheterization, has in recent years been widely used in clinic, has been especially suitable for Tumor Patients after Chemotherapy.But in conduit use procedure, it has been found that the incidence rate of mechanical phlebitis caused by PICC is higher, takes second place for venous thrombosis.Clinically, for the PICC phlebitis caused, medical personnel's many employings soak or some blood circulation promoting and blood stasis dispelling of external, reducing swelling and alleviating pain medicine are treated, but also existing in various degree take effect slow, cost is high or injury of primary destroys the defect of blood vessel；For the PICC phlebothrombosis caused, tradition western medical treatment mainly includes the method such as anticoagulant, thrombolytic, being typically in the thrombosis initial stage has significant curative effect, but for the thrombosis formed, DeGrain, not only cause certain misery to patient, and have even cause tube drawing because measure is invalid.While affecting patient treatment, also cause economic loss to patient.Prevention thought according to the traditional Chinese medical science " preventive treatment of disease ", i.e. prevention of diseae and preventing exacerbation after being taken ill, namely this research take early intervention measure, prevention and treatment PICC phlebitis, phlebothrombosis after PICC puts pipe.
Summary of the invention
The technical problem to be solved is to overcome the deficiencies in the prior art, there is provided the one that a kind of cost is low, preparation is convenient, medicine source is wide, evident in efficacy, have no side effect for preventing and treat PICC phlebitis, venothrombotic Chinese medicinal ointment and preparation method, and drug dose is optimized.
This invention address that above-mentioned technical problem employed technical scheme comprise that a kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment, in conjunction with theory of Chinese medical science and clinical application effect, it is surprised to find with Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Herba Asari, Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Glycyrrhizae, Rhizoma Coptidis, Flos Lonicerae, Radix Angelicae Sinensis, Herba Hedyotidis Diffusae, the compositions of Herba Scutellariae Barbatae composition is compared the combination of its medicinal herbs most in use and commonly uses Chinese patent medicine to PICC phlebitis, phlebothrombosis has unforeseeable prevention and therapeutic effect, drug dose has been screened by inventor further on the basis of aforementioned pharmaceutical compositions, it is finally obtained the most preferred technical scheme of the present invention, this optimal case is compared other consumptions and is had unforeseeable prevention and treatment phlebitis and venothrombotic effect, refer to specific embodiment.
The raw material weight of the present composition consists of: Cortex Moutan 8-16g, Radix Paeoniae Rubra 8-16g, Rhizoma Chuanxiong 11-19g, Herba Asari 1-7g, Rhizoma Zingiberis 2-10g, Radix Salviae Miltiorrhizae 26-34g, Flos Carthami 8-16g, Radix Glycyrrhizae 2-10g, Rhizoma Coptidis 2-10g, Flos Lonicerae 26-34g, Radix Angelicae Sinensis 8-16g, Herba Hedyotidis Diffusae 11-19g, Herba Scutellariae Barbatae 11-19g.Preferred Cortex Moutan 9g, Radix Paeoniae Rubra 12g, Rhizoma Chuanxiong 15g, Herba Asari 3g, Rhizoma Zingiberis 6g, Radix Salviae Miltiorrhizae 28g, Flos Carthami 12g, Radix Glycyrrhizae 6g, Rhizoma Coptidis 6g, Flos Lonicerae 26g, Radix Angelicae Sinensis 12g, Herba Hedyotidis Diffusae 12g, Herba Scutellariae Barbatae 13g.Taking each component medicine by weight ratio and be developed into superfines mix homogeneously, superfines is added stirring in Oleum Brassicae campestris and makes by the ratio in 1: 4～5.
In the present invention, the mechanism of medication medicine is as follows:
Cortex Moutan: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling
Radix Paeoniae Rubra: clearing away heat and cooling blood, dissipating blood stasis for subsidence of swelling pain relieving
Rhizoma Chuanxiong: blood-activating and qi-promoting wind-expelling pain-stopping
Herba Asari: expelling wind and cold, sensible pain relieving
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant
Radix Salviae Miltiorrhizae: promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, removing heat from blood is subsided a swelling, and clear away heart-fire relieving restlessness
Flos Carthami: blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain
Radix Glycyrrhizae: QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind and heat pathogens
Radix Angelicae Sinensis: replenishing and activating blood, promoting blood circulation and stopping pain
Herba Hedyotidis Diffusae: heat clearing away, dampness removing, removing toxic substances, eliminating carbuncle
Herba Scutellariae Barbatae: heat-clearing and toxic substances removing, changes silt diuresis
Oleum Brassicae campestris sweet in the mouth, pungent, warm in nature, parasite killing can be moisturized, dissipate erysipelas, detumescence poison, reconcile into paste Local out dressing with above-mentioned all medicines, good penetrability, take effect rapidly.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
A kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment, take each component medicine by weight ratio and clean and dry, being ground into granular size is 50 microns of powder, and ultrafine pharmaceutical powders is added by the ratio in 1: 4 to be mixed well in Oleum Brassicae campestris.
After using method: PICC puts pipe success, namely about 3cm place follows capable upper arm superficial vein one layer of Chinese medicinal ointment of trend aseptic cotton carrier uniform application along conduit above point of puncture to take the Chinese medicinal ointment in above table or positive control medicine (commercially available YUNNAN BAIYAO powder added by ultrafine pharmaceutical powders in the ratio of 1: 4 mix well in Oleum Brassicae campestris), scope is from puncturing vein both sides 3-4cm, long 8-10cm is moved towards along vein, do not stop to dab to rub and rub to skin heating in order to drug osmotic, better play drug effect, morning, noon and afternoon every day smearing ointment is each once, continuous seven days, blank group is not applied medicinal lotion or ointment.
Case selection: put pipe chemotherapy at I institute's oncology row PICC first and agree to participate in inpatient totally 900 example of this research, inclusive criteria: 9 groups of patient vessel's conditions meet PICC and put pipe requirement；Make a reservation for intubate position without radiotherapy, phlebothrombosis, vascular operation history or erythra, skin injury；Coagulation function is normal；Need a large amount of input stimulus liquid；Once holding tube success；Two groups of patients all without allergies, comparing difference not statistically significant in sex, age etc., there is comparability. often organizing each 100 examples, PICC is punctured by standard method by the nurse specially trained, skilled operation specified.
PICC phlebitis diagnostic criteria: according to venous transfusion nurses association of U.S. phlebitis grade scale.0 grade: without clinical symptoms；1 grade: local pain, red and swollen or edema, vein, without streak change, does not touch scleroma；2 grades: local pain, red and swollen or edema, the streak change of vein, do not touch scleroma；3 grades: local pain, red and swollen or edema, the streak change of vein, can touch scleroma.
PICC phlebothrombosis diagnostic criteria: put tube side upper limb swelling, pain, skin temperature increase, and make a definite diagnosis through color Doppler.
PICC phlebitis treatment evaluation criterion:
Recovery from illness: inflammation disappears, blood vessel recovers elasticity, and skin colour is consistent；
Effective: swelling pain disappears gradually, clinical symptoms is obviously improved.
Therapeutic Method: 9 groups of patients carry out puncture and intubation by the nurse specially trained, skilled operation specified by standard method, and give PICC relevant health education.After experimental group patient P ICC puts pipe success, namely prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment are taken, above point of puncture, about 3cm place follows capable upper arm superficial vein one layer of Chinese medicinal ointment of trend aseptic cotton carrier uniform application along conduit, scope is from puncturing vein both sides 3-4cm, long 8-10cm is moved towards along vein, not stopping to dab to rub to rub to skin heating and better play drug effect in order to drug osmotic, morning, noon and afternoon every day smearing ointment is each once, continuous seven days.
Therapeutic effect
Through statistical analysis, the unguentum phlebitis incidence rate of experiment 3 is relative to testing 1,2,4,5 and blank group and positive controls difference extremely notable (p 0.01), experiment 1,2,4,5 group differences not notable (p 0.05), significant difference (p 0.05) compared with contrast 1 and 2, difference extremely notable (p 0.01) compared with blank group, with positive controls significant difference (p 0.05).In prevention phlebothrombosis, experiment 1-5 and contrast 1 and 2 and blank group compared with difference extremely notable (p 0.01)
By 18 example positive cases of 12 example positive cases in positive controls and blank group, adopting the Chinese medicinal ointment of experiment 3 to smear every day, the scorching 28 example recoveries from illness of posterior vein in 7 days, 2 examples are effective, and 20 example phlebothrombosises all disappear.
Model case:
Case 1
Liu, female, 41 years old.After PICC venous transfusion, PICC implanting portion local pain, redness, scorching hot；The drug ointment adopting the present invention smears affected part 2, pain relief；Continuing to smear affected part 2, red and swollen heat pain disappears, and cures.
Case 2
Zhang, man, 49 years old.After PICC venous transfusion, PICC implanting portion local pain, redness；There is rope strip in vein, can touch scleroma；The drug ointment adopting the present invention smears affected part 2, pain relief；Continuing to smear affected part 5, patient PICC implanting portion red and swollen heat pain disappears, and strand runner or tuberosity disappear completely, cures.

Claims (3)

1.A kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment, it is characterised in that its raw material consist of Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Herba Asari, Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Glycyrrhizae, Rhizoma Coptidis, Flos Lonicerae, Radix Angelicae Sinensis, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae.
2.Such as claimDescribed in 1A kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointment, it is characterised in that the weight of its raw material consists of: Cortex Moutan 8-16g, Radix Paeoniae Rubra 8-16g, Rhizoma Chuanxiong 11-19g, Herba Asari 1-7g, Rhizoma Zingiberis 2-10g, Radix Salviae Miltiorrhizae 26-34g, Flos Carthami 8-16g, Radix Glycyrrhizae 2-10g, Rhizoma Coptidis 2-10g, Flos Lonicerae 26-34g, Radix Angelicae Sinensis 8-16g, Herba Hedyotidis Diffusae 11-19g, Herba Scutellariae Barbatae 11-19g.
3.Such as claimDescribed described in 2A kind of prevention and treatment PICC phlebitis, venothrombotic Chinese medicinal ointmentIt is characterized in that the weight of its raw material consists of: Cortex Moutan 9g, Radix Paeoniae Rubra 12g, Rhizoma Chuanxiong 15g, Herba Asari 3g, Rhizoma Zingiberis 6g, Radix Salviae Miltiorrhizae 28g, Flos Carthami 12g, Radix Glycyrrhizae 6g, Rhizoma Coptidis 6g, Flos Lonicerae 26g, Radix Angelicae Sinensis 12g, Herba Hedyotidis Diffusae 12g, Herba Scutellariae Barbatae 13g, taking each component medicine by weight ratio and be developed into superfines mix homogeneously, superfines is added stirring in Oleum Brassicae campestris and makes by the ratio in 1: 4～5.
CN201610174709.2A 2016-03-25 2016-03-25 Traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis Withdrawn CN105709195A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643647A (en) * 2020-04-30 2020-09-11 南京益鸣生物科技有限公司 Traditional Chinese medicine composition for blood vessel maintenance

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001140A (en) * 2014-06-10 2014-08-27 贾爱玲 Paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001140A (en) * 2014-06-10 2014-08-27 贾爱玲 Paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643647A (en) * 2020-04-30 2020-09-11 南京益鸣生物科技有限公司 Traditional Chinese medicine composition for blood vessel maintenance

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