CN105688231B - A kind of gastrointestinal image agent and preparation method thereof - Google Patents
A kind of gastrointestinal image agent and preparation method thereof Download PDFInfo
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- CN105688231B CN105688231B CN201610124001.6A CN201610124001A CN105688231B CN 105688231 B CN105688231 B CN 105688231B CN 201610124001 A CN201610124001 A CN 201610124001A CN 105688231 B CN105688231 B CN 105688231B
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- image agent
- liquid metal
- barium sulfate
- gastrointestinal image
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
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- Life Sciences & Earth Sciences (AREA)
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Abstract
The present invention relates to a kind of gastrointestinal image agent and preparation method thereof, described its component of gastrointestinal image agent includes liquid metal and barium sulfate.Compared to traditional barium meal contrast medium, development effect is excellent for the gastrointestinal image agent.In addition, the contrast agent can all be discharged from alimentary canal, biological safety is good.The gastrointestinal image agent of this method preparation, preparation process is simple, and imaging effect is excellent, good biocompatibility.
Description
Technical field
The invention belongs to contrast medium technique fields, and in particular to a kind of gastrointestinal image agent and preparation method thereof.
Background technique
Alimentary canal including oesophagus, stomach, small intestine and large intestine needs contrast agent auxiliary just can be in x-ray when checking
The form and function of the gastral lesion of the lower display of irradiation change, to obtain the details of lesions position.Wherein, barium sulfate
It is clinically most common gastrointestinal image agent, and imaging effect also heavily depends on the contrast ability of contrast agent.
Using gallium be the liquid metal of representative have not less than common metal X-ray absorption coefficient, thus X-ray shooting or
In CT scan, the tissue for being filled with liquid metal can form sharp contrast with surrounding tissue, reach excellent contrast imaging effect.
Therefore, if contrasting effects can be obviously improved using liquid metal as a kind of gastrointestinal image agent.But pure liquid metal
Contrast agent, metal artifacts are too strong in X-ray shooting or CT scan, while being not easy wall built-up, this can all be unfavorable for being imaged.
Summary of the invention
In order to solve the above technical problems, preparing the purpose of the present invention is to provide a kind of simply and with extremely strong contrast ability
Gastrointestinal image agent.
Realize that the object of the invention technical solution is as follows:
A kind of gastrointestinal image agent, component include liquid metal and barium sulfate.
Preferably, the gastrointestinal image agent, its component includes 0.1-5 parts of liquid metal, barium sulfate in parts by weight
0.1-50 parts.
It is further preferred that the gastrointestinal image agent, its component includes 0.5-1 parts of liquid metal, sulphur in parts by weight
Sour barium 0.5-20 parts.
It is further preferred that the gastrointestinal image agent, its component includes 1 part of liquid metal, sulfuric acid in parts by weight
1-20 parts of barium.
Preferably, the gastrointestinal image agent, its component includes 1 part of liquid metal, 10 parts of barium sulfate in parts by weight.
Above-mentioned gastrointestinal image agent, component further include appropriate amount of deionized water.
Preferably, the liquid metal be one of galliums base liquid metal such as gallium, gallium indium, gallium indium tin, gallium indium tin zinc or
It is several；It is further preferred that the liquid metal is gallium.
Preferably, the barium sulfate is barium sulfate powder, and partial size is less than or equal to 10 μm；It is easy to uniformly mix with liquid metal
It closes, and development effect can be promoted.
Or preferably, the barium sulfate is that barium sulfate for suspension for example can be II type barium sulfate for suspension.
In order to preferably promote development effect, foaming agent can also be added, be contrasted radiography.
Preferably, the foaming agent includes that sodium bicarbonate, calcium carbonate, magnesium carbonate etc. are one such or several.
Parts by weight of the present invention can be the unit of weight well known in the art such as μ g, mg, g, kg, be also possible to it again
Number, such as 1/10,1/100,10 times, 100 times.
The research of the invention finds that it is aobvious to there is significant collaboration when being used as gastrointestinal image agent between liquid metal, barium sulfate
Shadow effect, compared to traditional barium meal contrast medium, development effect is more excellent.Further, research is found when liquid metal, sulfuric acid
Barium collaboration development effect when said ratio range compounds is more prominent.
Gastrointestinal image agent application range of the present invention includes the radiography of the radiophotographies such as x-ray, CT.
As needed, gastrointestinal image agent of the present invention can be used for upper digestive tract, all-digestive tract include esophagus, stomach,
The single, double comparison contrast examination such as duodenum, small intestine, colon.
The present invention also provides the preparation methods of above-mentioned gastrointestinal image agent, comprising the following steps:
It goes bail for according to the proportion and holds the liquid metal and barium sulfate powder of liquid condition, mix, and appropriate amount of deionized water is added,
Stir evenly to get.
It is preferred that being stirred with magnetic stirring apparatus；It is preferred that mixing time is 20h~30h.
Specifically, the preparation method of the gastrointestinal image agent, comprising the following steps:
1) liquid metal is heated to certain temperature, it is made to keep liquid condition；
2) it goes bail for according to the proportion and holds the liquid metal and barium sulfate powder of liquid condition, mix, and appropriate deionization is added
Water；
3) it is stirred with magnetic stirring apparatus, is uniformly mixed it, mixing time is 20h~30h.
Present invention has the advantages that gastrointestinal image agent development effect of the present invention is excellent compared to traditional barium meal contrast medium
It is different.In addition, gastrointestinal image agent of the present invention can all be discharged from alimentary canal, biological safety is good.Novel the disappearing of this method preparation
Change road contrast agent, preparation process is simple, and contrast ability is extremely strong, and imaging effect is excellent, good biocompatibility.
Detailed description of the invention
Fig. 1 is that 1 gained gastrointestinal image agent of the embodiment of the present invention pours into the interior radiography with barium sulfate of normal mouse alimentary canal
Effect contrast figure.
Fig. 2 (a) is that 1 gained gastrointestinal image agent of the embodiment of the present invention is poured into the stomach of normal mouse, is all arranged to mouse
Out after contrast agent, the histotomy figure of small intestine.
Fig. 2 (b) is the mouse small intestine histotomy figure of non-perfusion digestion road contrast agent.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical solution in the embodiment of the present invention is explicitly described, it is clear that described embodiment is the present invention
A part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, shall fall within the protection scope of the present invention.
With specific embodiment, the present invention is described in further detail below.
Embodiment 1
A kind of gastrointestinal image agent, the component including following proportion: 1g liquid metal gallium, 10g barium sulfate powder (partial size 10
μm), 10g deionized water.
The preparation method of the gastrointestinal image agent includes:
1) container equipped with gallium is put into 40 DEG C of hot water, after about 15min, gallium becomes liquid, spare.
2) it goes bail for according to said ratio the liquid metal gallium for holding liquid condition, barium sulfate powder, mixing, and deionization is added
Water.
3) said mixture is placed on magnetic stirring apparatus and is stirred, after stirring for 24 hours, liquid metal gallium and blanc fixe
End can be adequately uniformly mixed, and gained mixture is gastrointestinal image agent of the invention.
Embodiment 2
A kind of gastrointestinal image agent, the component including following proportion: 1g liquid metal gallium, 20g barium sulfate powder, 5 μ of partial size
M, 20g deionized water.The preparation method of the gastrointestinal image agent is similar to Example 1.
Embodiment 3
A kind of gastrointestinal image agent, the component including following proportion: 10g liquid metal gallium, 10g barium sulfate powder, partial size 2
μm, 10g deionized water.The preparation method of the gastrointestinal image agent is similar to Example 1.
Embodiment 4
A kind of gastrointestinal image agent, the component including following proportion: 0.5g liquid metal gallium, 20g barium sulfate powder, partial size
2 μm, 20g deionized water.The preparation method of the gastrointestinal image agent is similar to Example 1.
Embodiment 5
A kind of gastrointestinal image agent, the component including following proportion: 0.1g liquid metal gallium, 50g barium sulfate powder, partial size
5 μm, 50g deionized water.The preparation method of the gastrointestinal image agent is similar to Example 1.
Embodiment 6
A kind of gastrointestinal image agent, the component including following proportion: 5g liquid metal gallium, 50g barium sulfate powder, 5 μ of partial size
M, 50g deionized water.The preparation method of the gastrointestinal image agent is similar to Example 1.
Embodiment 7
A kind of gastrointestinal image agent, the difference with embodiment 1, which is only that, replaces with liquid metal gallium indium for liquid metal gallium
(wherein gallium mass ratio is 24.5%).Preparation method is the difference from embodiment 1 is that according to the proportion by gallium and indium in step 1)
80 DEG C are heated to, be stirred after gallium and indium become liquid and is cooled down simultaneously, is just that the gallium indium of liquid closes at room temperature
Gold, it is spare.Preparation process operates under oxygen-free environment.
Embodiment 8
A kind of gastrointestinal image agent, the difference with embodiment 7, which is only that, replaces with liquid metal gallium for liquid metal gallium indium
Indium tin (gallium, indium, tin mass ratio are 68.5:21.5:10).Preparation process operates under oxygen-free environment.
Embodiment 9-16
Gastrointestinal image agent, to be separately added into foaming agent carbonic acid again on the basis of embodiment 1-8 gastrointestinal image agent
Calcium, the dosage of foaming agent are the 5% of gastrointestinal image agent weight.
Experimental example 1
1, experimental material and instrument:
The prepared gastrointestinal image agent of embodiment 1；Barium sulfate suspension (barium meal)；No. 9 intragastric administration on mice needles；Toy
CT。
2, experimental animal: Healthy female BALB/C mice, 8 weeks, average 20g, purchased from Tsinghua University's biomedicine animal
The heart.
3, experimental method: mouse is randomly divided into experimental group, control group 1 and 2.Experimental group will disappear obtained by embodiment 1
Change road contrast agent to be circulated into Mouse Stomach by No. 9 intragastric administration on mice needles；Equivalent barium sulfate suspension is perfused in control group 1；Control group 2
Equivalent liquid metal gallium is perfused.CT scan is carried out after each group stomach-filling.After stomach-filling 12h, takes experimental group and contrast agent is not perfused just
Normal each one of mouse, makes small bowel tissue sections.After mouse all discharge contrast agent, the time is recorded.Continue to observe mouse, hold
It is 20 days continuous.
4, experimental result:
Fig. 1 is that 1 gained gastrointestinal image agent of the embodiment of the present invention pours into the interior radiography with barium sulfate of normal mouse alimentary canal
Effect contrast figure, wherein Fig. 1 (a) is the mouse of stomach-filling barium sulfate suspension (barium meal), Fig. 1 (b)) it is 1 gained of stomach-filling embodiment
The mouse of gastrointestinal image agent.The results show that the resulting gastrointestinal image agent development effect of the present invention is more compared to barium sulfate
Good, alimentary canal is clear in structure visible.
In experiment, the mouse of stomach-filling liquid metal gallium, since liquid metal is not easy wall built-up, the imaging of alimentary canal profile is unclear
It is clear, and liquid metal is too high for X-ray absorption coefficient, causes metal artifacts in CT image larger, makes to alimentary canal imaging
At interference.
Observation experiment group mouse, after about 8h after, gastrointestinal image agent is discharged since in mouse.It, will be small after about 36h
Mouse is put into toy CT and is scanned, and image result shows that the agent of alimentary canal interimage drains completely.
Continue to observe mouse survival situation, compared with normal mouse, no significant difference.
Fig. 2 (a) is that 1 gained gastrointestinal image agent of the embodiment of the present invention is poured into the stomach of normal mouse, is all arranged to mouse
Out after contrast agent, the histotomy figure of small intestine.The mouse small intestine histotomy figure of non-perfusion digestion road contrast agent.The results show that
Perfusion digestion road contrast agent has no obvious damage to the excretory organs such as mouse alimentary canal and liver kidney in a short time, obtained by the present invention
Gastrointestinal image agent is safe.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (11)
1. a kind of gastrointestinal image agent, which is characterized in that its component includes liquid metal and barium sulfate；The liquid metal is
One or more of gallium, gallium indium, gallium indium tin, gallium indium tin zinc.
2. gastrointestinal image agent according to claim 1, which is characterized in that its component includes liquid metal in parts by weight
0.1-5 parts, 0.1-50 parts of barium sulfate.
3. gastrointestinal image agent according to claim 1, which is characterized in that its component includes liquid metal in parts by weight
0.5-1 parts, 0.5-20 parts of barium sulfate.
4. gastrointestinal image agent according to claim 1, which is characterized in that the gastrointestinal image agent, in parts by weight
Its component includes 1 part of liquid metal, 1-20 parts of barium sulfate.
5. gastrointestinal image agent according to claim 1, which is characterized in that its component includes liquid metal in parts by weight
1 part, 10 parts of barium sulfate.
6. gastrointestinal image agent according to claim 1-5, which is characterized in that further include appropriate amount of deionized water；
And/or foaming agent.
7. gastrointestinal image agent according to claim 1-5, which is characterized in that the barium sulfate is blanc fixe
End, partial size are less than or equal to 10 μm.
8. gastrointestinal image agent according to claim 1-5, which is characterized in that the barium sulfate is dry for barium sulfate
Suspension.
9. the preparation method of any one of the claim 1-8 gastrointestinal image agent, which comprises the following steps: press
It goes bail for according to proportion and holds the liquid metal and barium sulfate powder of liquid condition, mix, and appropriate amount of deionized water is added, stir evenly,
To obtain the final product.
10. preparation method according to claim 9, which is characterized in that be stirred with magnetic stirring apparatus；Mixing time is
20h~30h。
11. preparation method according to claim 9 or 10, which comprises the following steps:
1) liquid metal is heated to certain temperature, it is made to keep liquid condition；
2) it goes bail for according to the proportion and holds the liquid metal and barium sulfate powder of liquid condition, mix, and appropriate amount of deionized water is added；
3) it is stirred with magnetic stirring apparatus, is uniformly mixed it, mixing time is 20h ~ 30h.
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| CN201610124001.6A CN105688231B (en) | 2016-03-04 | 2016-03-04 | A kind of gastrointestinal image agent and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038379A (en) * | 1976-03-24 | 1977-07-26 | Nikolai Petrovich Elinov | Composition for roentgenoscopy of the gastrointestinal tract containing a polysaccharide stabilizer |
| CN103893782A (en) * | 2014-03-07 | 2014-07-02 | 莱芜钢铁集团有限公司医院 | Barium sulfate suspension specially used for digestive tract dual-contrast radiography X-ray examination and preparation method of barium sulfate suspension |
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2016
- 2016-03-04 CN CN201610124001.6A patent/CN105688231B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038379A (en) * | 1976-03-24 | 1977-07-26 | Nikolai Petrovich Elinov | Composition for roentgenoscopy of the gastrointestinal tract containing a polysaccharide stabilizer |
| CN103893782A (en) * | 2014-03-07 | 2014-07-02 | 莱芜钢铁集团有限公司医院 | Barium sulfate suspension specially used for digestive tract dual-contrast radiography X-ray examination and preparation method of barium sulfate suspension |
Non-Patent Citations (3)
| Title |
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| CT用硫酸钡造影剂的制备;李惠芝 等;《沈阳药科大学学报》;20010930;第18卷(第5期);第313-315页 |
| Liquid Metal Angiography for Mega Contrast X-Ray Visualization of Vascular Network in Reconstructing In-Vitro Organ Anatomy;Qian Wang et al;《IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING》;20140415;第61卷(第7期);摘要和图1 |
| 刘静团队提出液态金属血管造影术可快速重建高清晰血管网络;医学院;《新清华》;20140606;第1-2页 |
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