CN105688007A - Preparation method of ferment capable of maintaining and repairing liver function - Google Patents
Preparation method of ferment capable of maintaining and repairing liver function Download PDFInfo
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Abstract
The invention discloses a preparation method of ferment capable of maintaining and repairing the liver function. The method includes the following steps that fermentation garlic is peeled and minced into paste, and fermentation garlic paste is obtained; kudzuvine flowers, platycodon grandiflorum, kudzuvine roots, artificially-cultivated ginseng, bighead atractylodes rhizomes, barbary wolfberry fruits, poria cocos, Chinese yam, fructus amomi and pericarpium citri reticulatae are dried and then ground, and kudzuvine flower powder, platycodon grandiflorum powder, kudzuvine root powder, ginseng powder, bighead atractylodes rhizome powder, barbary wolfberry fruit powder, poria cocos powder, Chinese yam powder, fructus amomi powder and pericarpium citri reticulatae powder are obtained; the fermentation garlic paste is mixed with the kudzuvine flower powder, the platycodon grandiflorum powder, the kudzuvine root powder, the ginseng powder, the bighead atractylodes rhizome powder, the barbary wolfberry fruit powder, the poria cocos powder, the Chinese yam powder, the fructus amomi powder and the pericarpium citri reticulatae powder, and a composite material is obtained; water and honey are added into the composite material and mixed evenly, and a fermentation material is obtained; the fermentation material is added into a fermentation tank and fermented for 2-4 years at 40-50 DEG C, and a ferment stock solution is obtained. The ferment prepared through the method can effectively maintain and repair the liver function, is good for human health and has no side effect.
Description
Technical field
The present invention relates to food technology field, be specifically related to the preparation method that liver function ferment is repaired in maintenance。
Background technology
Ferment (fermentnutrition) refers to that plant carries out submerged fermentation, the less salt liquid of a kind of matters of containing biological activities of extraction。Ferment is also called enzyme (enzyme) or comprehensive plant enzyme, it it is the active macromolecules produced by organism with catalytic action, various biochemical reactions in organism, nearly all carrying out under the catalytic action of ferment, the biosis such as the metabolism of human body, caloric intake, growth and breeding all must flow through the help of ferment and just can complete。
Ferment originates from Japan, starts from earlier 1900s, has the history up to more than 80 years so far。Ferment can very gentle in body when, the various biochemical reaction of catalysis expeditiously, promote organism metabolism。Digestion, absorption, breathing, motion and reproduction in vital movement is all that ferment promotes course of reaction, and therefore, ferment is the basis that cell is depended on for existence。
Human body activities is required for the participation of enzyme, and the shortage of enzyme can damage the metabolism of health, the problem such as hypofunction, immunity reduction, dyspepsia occur, muscle power is not good, alimentation is bad。Lacking ferment and can allow health " sending out a warning ", supplementary ferment then can allow healthy happy, moreover it is possible to plays toxin expelling, beauty treatment, defying age, improve the effects such as subhealth state。
The liver internal maximum parenchymatous organ of behaviour, average by 300,000,000,000 hepatocyte knobs one-tenth, containing the enzyme of more than 2000 kinds in these hepatocyte, medium as human biochemistry's reaction, participate in all kinds of vital movement of human body, just because of these more than 2000 kinds of enzyme roles, liver is referred to as " the synthesization factory of human body "。Liver produces at metabolism, the generation of liver juice, removing toxic substances, blood coagulation, immunity, heat and all serves very important effect in Water-Electrolyte adjustment。Important metabolic organ in liver or human body, is synthetic protein, aminoacid, sugared and lipometabolic main place。The synthesis of cholic acid and combination, bilirubinic metabolism and ferrum, copper, vitamin storage all carry out in liver, poisonous substance produced in the metabolic process of inside and outside is also had scavenging action。
When liver disease damage, can be appreciated that liver parenchyma has by liver function test harmless, it is judged that stromal reaction, differentiate the curative effect etc. of various jaundice and the order of severity of liver damage, the differentiation of the state of an illness, medicine。Through liver functional testing, can clarify a diagnosis by adjuvant clinical as early as possible。The performance of abnormal liver function is as follows: digestive functional disturbance, loss of appetite, anorexia, Nausea and vomiting etc.；Hepatocellular damage also can cause the enzymes such as serum transaminase and increase, and cholinesterase reduces, and can cause weak, easily tired, drowsy etc.；Bile pigments Developmental and Metabolic Disorder, can cause jaundice；Metabolism obstacles of blood glucose, can cause lipids contents and change, and cholesterol biosynthesis and esterification ability reduce；Lipodystrophy can form fatty liver；Albumin dyssynthesis, causes ascites, hydrothorax etc. time serious；Vitamins dysbolismus, can cause pachylosis, nyctalopia, words inflammation, edema, dermatorrhagia, osteoporosis etc.；Thrombin dyssynthesis, can cause gingival hemorrhage, epistaxis etc.；Hormone metabolism is abnormal, can cause hyposexuality, menoxenia, skin arteriolar dilatation, occurs that spider angioma, liver palm, face are pitch-dark etc.。
In sum, liver function goes wrong human influence is very big, medically understands the concrete cause of disease generally by clinical symptoms, treats again through medicine, but the side effect of Drug therapy is known。If repairing liver function when finding corresponding symptom by dietetic therapy, it is very helpful to health。
Summary of the invention
Based on this, the present invention provides the preparation method that liver function ferment is repaired in a kind of maintenance, and ferment prepared by the method can maintenance and repair liver function, favourable health and will not having side effects effectively。
In order to realize the purpose of the present invention, the present invention by the following technical solutions:
The preparation method that liver function ferment is repaired in a kind of maintenance, comprises the steps:
Take fermentation Bulbus Allii 4-12 part, Flos puerariae lobatae 3-10 part, Radix Platycodonis 4-15 part, Radix Puerariae 4-12 part, artificial growth Radix Ginseng 4-12 part, Rhizoma Atractylodis Macrocephalae 4-12 part, Fructus Lycii 4-10 part, Poria 3-9 part, Rhizoma Dioscoreae 3-9 part, Fructus Amomi 3-6 part, Pericarpium Citri Reticulatae 3-5 part；
Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；
Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；
Described fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；
Described compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:2～4:1～3；
Described fermentation material is added in fermentation tank, at 40 DEG C-50 DEG C condition bottom fermentation 2-4, obtains ferment stock solution。
Wherein in some embodiments, the preparation method that liver function ferment is repaired in described maintenance, also comprise the steps: to mix described ferment stock solution with the weight ratio of 1:8～12 with water, and sterilization, obtain ferment oral liquid。
Wherein in some embodiments, described fermentation Bulbus Allii adopts following fermentation technology to obtain:
A, fresh garlic being placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 12-24h, the humidity of described freezer is 50%-85%；
B, the water of the Bulbus Allii epidermis of step A gained is dried；
C, being loaded in fermentation dish by the described Bulbus Allii after drying, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by described fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 30 DEG C-40 DEG C, humidity is 90%-100%, and fermentation time is 60-100 hour；
Second stage: temperature is 40 DEG C-50 DEG C, humidity is 70%-90%, and fermentation time is 70-120 hour；
Phase III: temperature is 60 DEG C-70 DEG C, humidity is 60%-90%, and fermentation time is 100-120 hour；
Fourth stage: temperature is 80 DEG C-90 DEG C, humidity is 50%-80%, and fermentation time is 70-120 hour；
In 5th stage: temperature is 60 DEG C-80 DEG C, humidity is 40%-70%, and fermentation time is 80-120 hour；
In 6th stage: temperature is 40 DEG C-60 DEG C, humidity is 30%-60%, and fermentation time is 100-120 hour。
Wherein in some embodiments, in described step A, before Bulbus Allii is sent into freezer, in sampling Detection Bulbus Allii, heavy metal and agriculture residual, send batch Bulbus Allii qualified for detection into freezer。
Wherein in some embodiments, in described step B, before the water of Bulbus Allii epidermis is dried, with vegetable washer, Bulbus Allii is cleaned up。
Wherein in some embodiments, also there is between described step B and step C step B1, described step B1 is: full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient after selection drying, bar long on Bulbus Allii and root is cut off, and Bulbus Allii according to size fractionation。
The preparation method that liver function ferment is repaired in maintenance of the present invention; formed by numerous food level component mixed fermentation; through test; preparation ferment can effectively maintenance and repair liver function; specifically: the several amino acids wherein contained can effectively suppress fatty liver and the damage to liver cell structure of the lipid peroxidation enzyme, protection modern is in the liver of sub-health state because the fast pressure of rhythm of life is big；Can effectively prevent and control three-hypers and complication thereof；It is natural antioxidant, there is effect of allaying tiredness, enhancing immunity；And the method all adopts conventional food material, material is easy to get, and method is easy。
Detailed description of the invention
For the ease of understanding the present invention, the present invention will be described more fully below。The present invention can realize in many different forms, however it is not limited to embodiment described herein。On the contrary, the purpose providing these embodiments is to make the understanding to the disclosure more thorough comprehensively。
Unless otherwise defined, all of technology used herein is identical with the implication that the those skilled in the art belonging to the present invention are generally understood that with scientific terminology。The term used in the description of the invention herein is intended merely to the purpose describing specific embodiment, it is not intended that in the restriction present invention。
Liver function ferment is repaired in maintenance of the present invention, and it includes the component of following weight portion:
Fermentation Bulbus Allii 4-12 part, Flos puerariae lobatae 3-10 part, Radix Platycodonis 4-15 part, Radix Puerariae 4-12 part, artificial growth Radix Ginseng 4-12 part, Rhizoma Atractylodis Macrocephalae 4-12 part, Fructus Lycii 4-10 part, Poria 3-9 part, Rhizoma Dioscoreae 3-9 part, Fructus Amomi 3-6 part, Pericarpium Citri Reticulatae 3-5 part。
Or, liver function ferment is repaired in described maintenance, including the component of following weight portion: fermentation Bulbus Allii 5-10 part, Flos puerariae lobatae 3-8 part, Radix Platycodonis 4-10 part, Radix Puerariae 4-10 part, artificial growth Radix Ginseng 4-10 part, Rhizoma Atractylodis Macrocephalae 4-10 part, Fructus Lycii 5-10 part, Poria 3-8 part, Rhizoma Dioscoreae 3-8 part, Fructus Amomi 3-6 part, Pericarpium Citri Reticulatae 3-5 part。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, fresh garlic being placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 12-24h, the humidity of described freezer is 50%-85%；
B, the water of the Bulbus Allii epidermis of step A gained is dried；
C, being loaded in fermentation dish by the described Bulbus Allii after drying, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by described fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 30 DEG C-40 DEG C, humidity is 90%-100%, and fermentation time is 60-100h；
Second stage: temperature is 40 DEG C-50 DEG C, humidity is 70%-90%, and fermentation time is 70-120h；
Phase III: temperature is 60 DEG C-70 DEG C, humidity is 60%-90%, and fermentation time is 100-120h；
Fourth stage: temperature is 80 DEG C-90 DEG C, humidity is 50%-80%, and fermentation time is 70-120h；
In 5th stage: temperature is 60 DEG C-80 DEG C, humidity is 40%-70%, and fermentation time is 80-120h；
In 6th stage: temperature is 40 DEG C-60 DEG C, humidity is 30%-60%, and fermentation time is 100-120h。
Wherein, in step A, before Bulbus Allii is sent into freezer, in sampling Detection Bulbus Allii, heavy metal and agriculture residual, send batch Bulbus Allii qualified for detection into freezer。
Wherein, in step B, before the water of Bulbus Allii epidermis is dried, with vegetable washer, Bulbus Allii is cleaned up。
Wherein, also having step B1, described step B1 between step B and step C is: full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient after selection drying, bar long on Bulbus Allii and root is cut off, and Bulbus Allii according to size fractionation。
The preparation method of liver function ferment is repaired in above-mentioned maintenance:
Take fermentation Bulbus Allii 4-12 part, Flos puerariae lobatae 3-10 part, Radix Platycodonis 4-15 part, Radix Puerariae 4-12 part, artificial growth Radix Ginseng 4-12 part, Rhizoma Atractylodis Macrocephalae 4-12 part, Fructus Lycii 4-10 part, Poria 3-9 part, Rhizoma Dioscoreae 3-9 part, Fructus Amomi 3-6 part, Pericarpium Citri Reticulatae 3-5 part；
Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；
Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；
Described fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；
Described compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:2～4:1～3；
Described fermentation material is added in fermentation tank, at 40 DEG C-50 DEG C condition bottom fermentation 2-4, obtains ferment stock solution。
Also comprise the steps: to mix described ferment stock solution with the weight ratio of 1:8～12 with water, and sterilization, obtain ferment oral liquid。
Hereinafter will further illustrate embodiments of the present invention by several embodiments。
Embodiment one
Liver function ferment is repaired in maintenance described in the present embodiment, including the component of following weight portion: fermentation Bulbus Allii 6 parts, Flos puerariae lobatae 4 parts, Radix Puerariae 5 parts, Radix Platycodonis 6 parts, artificial growth Radix Ginseng 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Lycii 5 parts, 5 parts of Poria, Rhizoma Dioscoreae 5 parts, Fructus Amomi 4 parts, Pericarpium Citri Reticulatae 3.5 parts。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, take fresh garlic, heavy metal and agriculture residual in sampling Detection Bulbus Allii, it is placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 18h by detecting qualified batch Bulbus Allii, wherein the humid control of freezer is 50%-85%；
B, with vegetable washer, the Bulbus Allii after step A freezing is cleaned up, Bulbus Allii is placed in drier the water of Bulbus Allii epidermis is dried；
After B1, selection drying, full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient, cut off bar long on Bulbus Allii and root, and Bulbus Allii according to size fractionation；
C, being loaded by Bulbus Allii in fermentation dish, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 35 DEG C, humidity is 95%, and fermentation time is 80h；Second stage: temperature is 45 DEG C, humidity is 80%, and fermentation time is 100h；Phase III: temperature is 65 DEG C, humidity is 75%, and fermentation time is 110h；Fourth stage: temperature is 85 DEG C, humidity is 65%, and fermentation time is 80h；In 5th stage: temperature is 70 DEG C, humidity is 55%, and fermentation time is 100h；In 6th stage: temperature is 50 DEG C, humidity is 45%, and fermentation time is 110h。
The preparation method of liver function ferment is repaired in above-mentioned maintenance: take fermentation Bulbus Allii 6 parts, Flos puerariae lobatae 4 parts, Radix Puerariae 5 parts, Radix Platycodonis 6 parts, artificial growth Radix Ginseng 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Lycii 5 parts, 5 parts of Poria, Rhizoma Dioscoreae 5 parts, Fructus Amomi 4 parts, Pericarpium Citri Reticulatae 3.5 parts；Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；Fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；Compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:3:2；Fermentation material is added in fermentation tank, 40 DEG C-50 DEG C condition bottom fermentations 3 years, obtain ferment stock solution, ferment stock solution is mixed with the weight ratio of 1:10 with water, and pasteurization sterilizing, obtain ferment oral liquid。
This ferment oral liquid is directly administered orally, one day twice, a 80-100 milliliter。
The following is the test data for above-described embodiment one:
1, Cao, man, 49 years old。Daily inspection in October 13 in 2014, liver function: total bilirubin 76.20umol/L ↑, bilirubin direct 31.40umol/L ↑, albumin 30.3g/L ↓, albumins/globulins 0.8 ↓, globulin 37.7g/L ↑, TOTAL BILE ACID TBA 111.6umol/L ↑, adenosine deaminase 47.0U/L ↑, glutamic oxaloacetic transaminase, GOT 47U/L ↑, alkali phosphatase 133.0U/L ↑, acetylcholine esterase 3104U/L ↓。Patient's liver function is substantially impaired, the gloomy jaundice of face, poor sleeping quality。In November, 2014 starts to take this ferment, and 2015 02 month 07 daily inspection: total bilirubin 35.8umol/L ↑, bilirubin direct 15.7umol/L ↑, in vain/globulin than 1.09 ↓, other indexs all in normal range, patient's readme, autoimmunity improves, and face and mental restoration are normal。10 daily inspections in 05 month in 2015, liver function project all recovers normal。
2, Wu, man, 52 years old。29 daily inspections in 09 month in 2014, liver function: total protein 84.3g/L ↑, globulin 45.8g/L ↑, albumins/globulins ratio 0.84 ↓, glutamate pyruvate transaminase 71U/L ↑, glutamic oxaloacetic transaminase, GOT 45U/L ↑, alkali phosphatase 180U/L ↑, glutamyl transferase 311U/L ↑。Patient's face turns to be yellow, and expression in the eyes is unglazed, starts to obscure depending on thing。In October, 2014 starts to take this ferment, and after one month, the readme mental status is improved, depending on the fuzzy sense disappearance of thing。2015 01 month 17 daily inspection liver functions: glutamate pyruvate transaminase 47U/L ↑, glutamyl transferase 62U/L ↑, all the other projects are all in normal range。Continuing to take to 28 daily inspections in 02 month in 2015, whole projects of liver function are all normal。
Embodiment two:
Liver function ferment is repaired in maintenance described in the present embodiment, including the component of following weight portion: fermentation Bulbus Allii 4 parts, Flos puerariae lobatae 3 parts, Radix Platycodonis 4 parts, Radix Puerariae 4 parts, artificial growth Radix Ginseng 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Lycii 4 parts, 3 parts of Poria, Rhizoma Dioscoreae 3 parts, Fructus Amomi 3 parts, Pericarpium Citri Reticulatae 3 parts。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, take fresh garlic, heavy metal and agriculture residual in sampling Detection Bulbus Allii, it is placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 12h by detecting qualified batch Bulbus Allii, wherein the humidity of freezer is 50%-85%；
B, with vegetable washer, the Bulbus Allii after step A freezing is cleaned up, Bulbus Allii is placed in drier the water of Bulbus Allii epidermis is dried；
After B1, selection drying, full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient, cut off bar long on Bulbus Allii and root, and Bulbus Allii according to size fractionation；
C, being loaded by Bulbus Allii in fermentation dish, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 30 DEG C, humidity is 90%, and fermentation time is 60h；Second stage: temperature is 40 DEG C, humidity is 70%, and fermentation time is 70h；Phase III: temperature is 60 DEG C, humidity is 60%, and fermentation time is 100h；Fourth stage: temperature is 80 DEG C, humidity is 50%, and fermentation time is 70h；In 5th stage: temperature is 60 DEG C, humidity is 40%, and fermentation time is 80h；In 6th stage: temperature is 40 DEG C, humidity is 30%, and fermentation time is 100h。
The preparation method of liver function ferment is repaired in above-mentioned maintenance: take fermentation Bulbus Allii 4 parts, Flos puerariae lobatae 3 parts, Radix Platycodonis 4 parts, Radix Puerariae 4 parts, artificial growth Radix Ginseng 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Lycii 4 parts, 3 parts of Poria, Rhizoma Dioscoreae 3 parts, Fructus Amomi 3 parts, Pericarpium Citri Reticulatae 3 parts；Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；Fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；Compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:2:1；Fermentation material is added in fermentation tank, 40 DEG C-50 DEG C condition bottom fermentations 2 years, obtain ferment stock solution, ferment stock solution is mixed with the weight ratio of 1:8 with water, and pasteurization sterilizing, obtain ferment oral liquid。
This ferment oral liquid is directly administered orally, one day twice, a 80-100 milliliter。
The following is the test data for above-described embodiment two:
Wish certain, man, 46 years old。Health check-up on October 29 in 2014, liver function eight: AST43.2U/L ↑, glutamyl transferase 119.3U/L ↑, albumins/globulins 1.04 ↓, total bilirubin 21.5umol/L, bilirubin direct 6.8umol/L, unconjugated bilirubin 14.7umol/L。AFP is quantitative: alpha-fetoprotein (AFP) 48.1ng/mL ↑；Color ultrasound: liver parenchyma increases thick。In December, 2014 starts to take this ferment。05 daily inspection in 03 month in 2015: liver function: glutamyl transferase 55U/L ↑, all the other projects are all normal, and alpha-fetoprotein 6.8ng/mL (normally), color ultrasound shows liver Non Apparent Abnormality。
Liao, man, 48 years old。19 daily inspections in 05 month in 2014: glutamate pyruvate transaminase 56.1U/L ↑, glutamic oxaloacetic transaminase, GOT 40.9U/L ↑, glutamyl transferase 63.6U/L ↑；Ultrasonic examination: liver low echo area (right lobe of liver, 14 × 11mm), it is considered to heterogeneous body fatty liver is likely to。In JIUYUE, 2014 starts to take this ferment。25 daily inspections in 04 month in 2015: liver function project is all normal, and ultrasonic examination shows that liver low echo area is obviously reduced earlier above, is now 4 × 5mm。
Embodiment three:
Liver function ferment is repaired in maintenance described in the present embodiment, including the component of following weight portion: fermentation Bulbus Allii 12 parts, Flos puerariae lobatae 10 parts, Radix Platycodonis 15 parts, Radix Puerariae 12 parts, artificial growth Radix Ginseng 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Lycii 10 parts, 9 parts of Poria, Rhizoma Dioscoreae 9 parts, Fructus Amomi 6 parts, Pericarpium Citri Reticulatae 5 parts。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, take fresh garlic, heavy metal and agriculture residual in sampling Detection Bulbus Allii, it is placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 24h by detecting qualified batch Bulbus Allii, wherein the humid control of freezer is 50%-85%；
B, with vegetable washer, the Bulbus Allii after step A freezing is cleaned up, Bulbus Allii is placed in drier the water of Bulbus Allii epidermis is dried；
After B1, selection drying, full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient, cut off bar long on Bulbus Allii and root, and Bulbus Allii according to size fractionation；
C, being loaded by Bulbus Allii in fermentation dish, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 40 DEG C, humidity is 100%, and fermentation time is 100h；Second stage: temperature is 50 DEG C, humidity is 90%, and fermentation time is 120h；Phase III: temperature is 70 DEG C, humidity is 90%, and fermentation time is 120h；Fourth stage: temperature is 90 DEG C, humidity is 80%, and fermentation time is 120h；In 5th stage: temperature is 80 DEG C, humidity is 70%, and fermentation time is 120h；In 6th stage: temperature is 60 DEG C, humidity is 60%, and fermentation time is 120h。
The preparation method of liver function ferment is repaired in above-mentioned maintenance: take fermentation Bulbus Allii 12 parts, Flos puerariae lobatae 10 parts, Radix Platycodonis 15 parts, Radix Puerariae 12 parts, artificial growth Radix Ginseng 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Lycii 10 parts, 9 parts of Poria, Rhizoma Dioscoreae 9 parts, Fructus Amomi 6 parts, Pericarpium Citri Reticulatae 5 parts；Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；Fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；Compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:4:3；Fermentation material is added in fermentation tank, 40 DEG C-50 DEG C condition bottom fermentations 4 years, obtain ferment stock solution, ferment stock solution is mixed with the weight ratio of 1:12 with water, and pasteurization sterilizing, obtain ferment oral liquid。
This ferment oral liquid is directly administered orally, one day twice, a 80-100 milliliter。
The following is the test data for above-described embodiment three:
Liu, man, 27 years old。15 daily inspections in 04 month in 2014: liver function eight: ALT68.4U/L ↑, AST39.5U/L ↑；Four items of blood lipid tests: T-CHOL 5.26mmol/L ↑；Hepatitis B virus: HBsAg (+), HBsAb (-), HBeAg (+), HBeAb (-), HBcAb (+) hepatitis B virus carriers。In JIUYUE, 2014 starts to take this ferment。14 daily inspections in 05 month in 2015: liver function project is all normal, Hepatitis B virus: one, five positives。
Wang, man, 44 years old。21 daily inspections in 04 month in 2015: liver function: glutamate pyruvate transaminase 40.3U/L ↑, gamma glutamyl transpeptidase 47.7U/L ↑, glutamic oxaloacetic transaminase, GOT 45.4U/L ↑, patient suffers from three-hypers。In May, 2015 starts to take this ferment, 20 daily inspections in 07 month in 2015: liver function project is all normal, and blood fat project is also normal。
Embodiment four:
Liver function ferment is repaired in maintenance described in the present embodiment, including the component of following weight portion: fermentation Bulbus Allii 5 parts, Flos puerariae lobatae 3 parts, Radix Platycodonis 4 parts, Radix Puerariae 4 parts, artificial growth Radix Ginseng 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Lycii 5 parts, 3 parts of Poria, Rhizoma Dioscoreae 3 parts, Fructus Amomi 3 parts, Pericarpium Citri Reticulatae 3 parts。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, take fresh garlic, heavy metal and agriculture residual in sampling Detection Bulbus Allii, it is placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 18h by detecting qualified batch Bulbus Allii, wherein the humid control of freezer is 50%-85%；
B, with vegetable washer, the Bulbus Allii after step A freezing is cleaned up, Bulbus Allii is placed in drier the water of Bulbus Allii epidermis is dried；
After B1, selection drying, full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient, cut off bar long on Bulbus Allii and root, and Bulbus Allii according to size fractionation；
C, being loaded by Bulbus Allii in fermentation dish, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 35 DEG C, humidity is 95%, and fermentation time is 80h；Second stage: temperature is 45 DEG C, humidity is 80%, and fermentation time is 100h；Phase III: temperature is 65 DEG C, humidity is 75%, and fermentation time is 110h；Fourth stage: temperature is 85 DEG C, humidity is 65%, and fermentation time is 80h；In 5th stage: temperature is 70 DEG C, humidity is 55%, and fermentation time is 100h；In 6th stage: temperature is 50 DEG C, humidity is 45%, and fermentation time is 110h。
The preparation method of liver function ferment is repaired in above-mentioned maintenance: take fermentation Bulbus Allii 5 parts, Flos puerariae lobatae 3 parts, Radix Platycodonis 4 parts, Radix Puerariae 4 parts, artificial growth Radix Ginseng 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Lycii 5 parts, 3 parts of Poria, Rhizoma Dioscoreae 3 parts, Fructus Amomi 3 parts, Pericarpium Citri Reticulatae 3 parts；Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；Fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；Compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:3:2；Fermentation material is added in fermentation tank, 40 DEG C-50 DEG C condition bottom fermentations 3 years, obtain ferment stock solution, ferment stock solution is mixed with the weight ratio of 1:10 with water, and pasteurization sterilizing, obtain ferment oral liquid。
This ferment oral liquid is directly administered orally, one day twice, a 80-100 milliliter。
The following is the test data for above-described embodiment four:
Week certain, man, 37 years old。01 daily inspection in 01 month in 2015: hepatitis B virus 55IU/mL ↑；Hepatitis B virus: HBsAg (+), HBsAb (-), HBeAg (-), HBeAb (+), HBcAb (+)；Liver function: total bilirubin 33.9umol/L ↑, bilirubin direct 8.4umol/L ↑, gamma glutamyl transpeptidase 215U/L ↑, glutamate pyruvate transaminase 77U/L ↑, glutamic oxaloacetic transaminase, GOT 55U/L ↑；In March, 2015 starts to take this ferment。22 daily inspections in 06 month in 2015: Hepatitis B virus: one, five is positive, and liver function project is all in normal range。
Lee, female, 39 years old。Daily inspection in October 27 in 2014: 1, biochemical: globulin 38.5g/L ↑, white/ball ratio 1ng/mL ↓, bilirubin direct 1.3umol/L ↓, paddy the third transferring enzyme 97.1u/L ↑, millet straw transferring enzyme 42.0u/L ↑, gamma glutamyltransferase 105.6u/L ↑, lactic acid dehydrogenase 293.8u/L ↑。In November, 2014 starts to take this ferment, 15 daily inspections in 03 month in 2015: liver function: glutamyl transferase 60.3U/L ↑, all the other projects are all in normal range。
Embodiment five:
Liver function ferment is repaired in maintenance described in the present embodiment, including the component of following weight portion: fermentation Bulbus Allii 10 parts, Flos puerariae lobatae 8 parts, Radix Platycodonis 10 parts, Radix Puerariae 10 parts, artificial growth Radix Ginseng 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Lycii 10 parts, 8 parts of Poria, Rhizoma Dioscoreae 8 parts, Fructus Amomi 6 parts, Pericarpium Citri Reticulatae 5 parts。
Fermentation Bulbus Allii therein adopts following fermentation technology to obtain:
A, take fresh garlic, heavy metal and agriculture residual in sampling Detection Bulbus Allii, it is placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 20h by detecting qualified batch Bulbus Allii, wherein the humidity of freezer is 50%-85%；
B, with vegetable washer, the Bulbus Allii after step A freezing is cleaned up, Bulbus Allii is placed in drier the water of Bulbus Allii epidermis is dried；
After B1, selection drying, full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient, cut off bar long on Bulbus Allii and root, and Bulbus Allii according to size fractionation；
C, being loaded by Bulbus Allii in fermentation dish, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 30 DEG C, humidity is 90%, and fermentation time is 60h；Second stage: temperature is 40 DEG C, humidity is 70%, and fermentation time is 70h；Phase III: temperature is 60 DEG C, humidity is 60%, and fermentation time is 100h；Fourth stage: temperature is 80 DEG C, humidity is 50%, and fermentation time is 70h；In 5th stage: temperature is 60 DEG C, humidity is 40%, and fermentation time is 80h；In 6th stage: temperature is 40 DEG C, humidity is 30%, and fermentation time is 100h。
The preparation method of liver function ferment is repaired in above-mentioned maintenance: take fermentation Bulbus Allii 10 parts, Flos puerariae lobatae 8 parts, Radix Platycodonis 10 parts, Radix Puerariae 10 parts, artificial growth Radix Ginseng 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Lycii 10 parts, 8 parts of Poria, Rhizoma Dioscoreae 8 parts, Fructus Amomi 6 parts, Pericarpium Citri Reticulatae 5 parts；Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；Fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；Compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:2:1；Fermentation material is added in fermentation tank, 40 DEG C-50 DEG C condition bottom fermentations 3 years, obtain ferment stock solution, ferment stock solution is mixed with the weight ratio of 1:8 with water, and pasteurization sterilizing, obtain ferment oral liquid。
This ferment oral liquid is directly administered orally, one day twice, a 80-100 milliliter。
The following is the test data for above-described embodiment five:
Beam, female, 43 years old。Health check-up on June 15 in 2015: liver function: aspartic acid transferring enzyme 182.0U/L ↑, lactic acid dehydrogenase 605.7U/L ↑, NSC 334200 aminotransferase 274.9U/L ↑, gamma glutamyltransferase 380.1U/L ↑, alkali phosphatase 102.9U/L ↑, lactic acid dehydrogenase 284.8U/L ↑。In June, 2015 starts to take this ferment。19 daily inspections in 09 month in 2015: liver function: millet straw transferring enzyme 55.8U/L ↑, paddy the third transferring enzyme 64.2U/L ↑, glutamyl transferase 88.1U/L ↑, all the other projects are normal。Daily inspection in November 20 in 2015: liver function project is all normal。
Embodiment described above only have expressed the several embodiments of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention。It should be pointed out that, for the person of ordinary skill of the art, without departing from the inventive concept of the premise, it is also possible to making some deformation and improvement, these broadly fall into protection scope of the present invention。Therefore, the protection domain of patent of the present invention should be as the criterion with claims。
Claims (6)
1. the preparation method that liver function ferment is repaired in a maintenance, it is characterised in that comprise the steps:
Take fermentation Bulbus Allii 4-12 part, Flos puerariae lobatae 3-10 part, Radix Platycodonis 4-15 part, Radix Puerariae 4-12 part, artificial growth Radix Ginseng 4-12 part, Rhizoma Atractylodis Macrocephalae 4-12 part, Fructus Lycii 4-10 part, Poria 3-9 part, Rhizoma Dioscoreae 3-9 part, Fructus Amomi 3-6 part, Pericarpium Citri Reticulatae 3-5 part；
Fermentation Bulbus Allii peelled off crust and rubs pulping, obtaining fermentation Bulbus Allii slurry；
Respectively Flos puerariae lobatae, Radix Platycodonis, Radix Puerariae, artificial growth Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Poria, Rhizoma Dioscoreae, Fructus Amomi and Pericarpium Citri Reticulatae are carried out micropowder after drying, obtain Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder；
Described fermentation Bulbus Allii slurry is mixed with Flos puerariae lobatae powder, balloonflower powder, powder of Radix Puerariae, Radix Ginseng powder, Rhizoma Atractylodis Macrocephalae powder, Fructus Lycii powder, Poria powder, Rhizoma Dioscoreae powder, amomum powder and tangerine peel powder, and stirs, obtain compound material；
Described compound material adds water and Mel, mix homogeneously, obtains fermentation material, Qi Zhongshui, compound material, Mel part by weight be 10:2～4:1～3；
Described fermentation material is added in fermentation tank, at 40 DEG C-50 DEG C condition bottom fermentation 2-4, obtains ferment stock solution。
2. the preparation method that liver function ferment is repaired in maintenance according to claim 1, it is characterised in that: also comprise the steps: to mix described ferment stock solution with the weight ratio of 1:8～12 with water, and sterilization, obtain ferment oral liquid。
3. the preparation method that liver function ferment is repaired in maintenance according to claim 1, it is characterised in that: described fermentation Bulbus Allii adopts following fermentation technology to obtain:
A, fresh garlic being placed in the freezer that temperature is-10 DEG C～-2 DEG C storage 12-24h, the humidity of described freezer is 50%-85%；
B, the water of the Bulbus Allii epidermis of step A gained is dried；
C, being loaded in fermentation dish by the described Bulbus Allii after drying, a fermentation dish fills one layer of Bulbus Allii, is then placed in fermentation machine by described fermentation dish, and adjusts fermentation parameter by following fermentation stage and ferment:
First stage: temperature is 30 DEG C-40 DEG C, humidity is 90%-100%, and fermentation time is 60-100 hour；
Second stage: temperature is 40 DEG C-50 DEG C, humidity is 70%-90%, and fermentation time is 70-120 hour；
Phase III: temperature is 60 DEG C-70 DEG C, humidity is 60%-90%, and fermentation time is 100-120 hour；
Fourth stage: temperature is 80 DEG C-90 DEG C, humidity is 50%-80%, and fermentation time is 70-120 hour；
In 5th stage: temperature is 60 DEG C-80 DEG C, humidity is 40%-70%, and fermentation time is 80-120 hour；
In 6th stage: temperature is 40 DEG C-60 DEG C, humidity is 30%-60%, and fermentation time is 100-120 hour。
4. the preparation method that liver function ferment is repaired in maintenance according to claim 3, it is characterised in that: in described step A, before Bulbus Allii is sent into freezer, in sampling Detection Bulbus Allii, heavy metal and agriculture residual, send batch Bulbus Allii qualified for detection into freezer。
5. the preparation method that liver function ferment is repaired in maintenance according to claim 3, it is characterised in that: in described step B, before the water of Bulbus Allii epidermis is dried, with vegetable washer, Bulbus Allii is cleaned up。
6. the preparation method that liver function ferment is repaired in maintenance according to claim 3, it is characterized in that: also there is between described step B and step C step B1, described step B1 is: full grains, nothing breakage and the normal and of uniform size Bulbus Allii of scar, color and luster and abnormal smells from the patient after selection drying, bar long on Bulbus Allii and root are cut off, and Bulbus Allii according to size fractionation。
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| CN112655950A (en) * | 2020-12-17 | 2021-04-16 | 重庆八零四零生物工程研究院有限公司 | Radix puerariae comprehensive enzyme |
| CN113925118A (en) * | 2021-09-28 | 2022-01-14 | 广西壮族自治区蚕业技术推广站 | Frost mulberry leaf traditional Chinese medicine enzyme beverage and preparation method thereof |
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