CN105687936A - Traditional Chinese medicine composition for treating female chronic urocystitis and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating female chronic urocystitis and preparation method of traditional Chinese medicine composition Download PDF

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CN105687936A
CN105687936A CN201610134561.XA CN201610134561A CN105687936A CN 105687936 A CN105687936 A CN 105687936A CN 201610134561 A CN201610134561 A CN 201610134561A CN 105687936 A CN105687936 A CN 105687936A
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parts
herba
chinese medicine
medicine composition
radix
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徐留玉
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Shandong Qianfoshan Hospital
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Shandong Qianfoshan Hospital
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Abstract

The invention provides traditional Chinese medicine composition for treating female chronic urocystitis. The traditional Chinese medicine composition is specially designed for patients suffering from female chronic urocystitis and is prepared from heartleaf houttuynia herbs, dandelions, suberect spatholobus stems, common andrographis herbs, pink herbs, chinaroot greenbier rhizomes, fruits of fiverleaf akebia, lygodium japonicum, nutgrass galingale rhizomes, szechwan chinaberry fruits, combined spicebush roots, roses, cassia bark, prepared common monkshood daughter roots, largehead atractylodes rhizomes, liquorice, Chinese angelica, prepared rehmannia roots, motherwort herbs, danshen roots and calcined oysters for comprehensive treatment targeted at related organs according to the pathogenesis and clinical manifestations of chronic urocystitis and specific and common constitution of females. The traditional Chinese medicine composition is prepared from various medicinal raw materials functioning comprehensively and accords with traditional Chinese medicine theories, the treatment effect is improved, repeated relapse is reduced, and pain of female patients is relieved. The invention further provides a preparation method of the traditional Chinese medicine composition for treating female chronic urocystitis.

Description

A kind of Chinese medicine composition treating women chronic cystitis and preparation method thereof
Technical field
The present invention relates to traditional Chinese medical science pharmaceutical technology field, especially relate to a kind of Chinese medicine composition treating women chronic cystitis and preparation method thereof。
Background technology
Cystitis is to occur at the inflammation of bladder, is mainly infected by specificity and non-specific antibacterial and causes, also has the cystitis of other specific type。Specific infection refers to tuberculosis of bladder。Nonspecific cystitis system escherichia coli, paracolon, Bacillus proteus, bacillus pyocyaneus, streptococcus faecalis and caused by Staphylococcus aureus。Its clinical manifestation has acute cystitis and chronic cystitis two kinds。
Under normal circumstances, bladder is relatively strong to the defensive ability/resistance ability of antibacterial, and a small amount of bacterial invasion is also harmless。Why bladder causes infection, is limited mainly by the resistance of health, and quantity and three conditions of route of infection of invasion antibacterial are driven, once the balance of these three condition suffers that destruction will cause infection。And women is short due to urethra, often being infected by the content closing on vagina and anus, cause that women is easier to cystitis, the sickness rate women of women generation cystitis is apparently higher than male。
Suffering from the women of cystitis except ceaselessly going to toilet, when urinating outside tingle, there is also hypogastric region paroxysmal pain, the urine that originally should be transparent becomes muddy。If chemical examination urine, it is possible to find under the microscope to be mixed with leukocyte and erythrocyte in urine。But antibacterial is not special bacterium, substantially escherichia coli etc.。Certainly, cystitis once worsen, then there will be hematuria, goes cold all over and more than 39 DEG C high hot。At this moment antibacterial upwards invades kidney along the ureter adverse current of patient both sides, it is possible to make impaired renal function evil, thus causing pyelonephritis。
Female bladder inflammation belongs to chronic cystitis more, and not easily eradicates, easy recurrent exerbation。
Therefore, how providing a kind of Chinese medicine composition being specifically designed for women chronic cystitis, improve curative effect, reduce recurrent exerbation, reducing the slight illness of female patient is that current those skilled in the art need badly and solve the technical problem that。
Summary of the invention
In view of this, it is an object of the invention to provide a kind of Chinese medicine composition treating women chronic cystitis, this Chinese medicine composition is specifically designed for women chronic cystitis patient design, pathogeny according to chronic cystitis and clinical manifestation, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly to solve pathogenic factor, select the multiple discomfort with very strong flavour of a drug kind targetedly and dose minimizing sufferer thereof simultaneously；Peculiar common body constitution according to women, relevant internal organs comprehensive measure, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly；Multiple flavour of a drug compatibility comprehensive function, meets theory of Chinese medical science, improves curative effect, decrease recurrent exerbation, decrease the slight illness of female patient。The preparation method that present invention also offers a kind of Chinese medicine composition treating women chronic cystitis。
For solving above-mentioned technical problem, technical scheme provided by the invention is:
A kind of Chinese medicine composition treating women chronic cystitis, is made up of the raw material of following weight portion:
Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part。
Preferably, Chinese medicine composition of the present invention is made up of the raw material of following weight portion:
Herba Andrographis 10 parts, Herba Taraxaci 10 parts, Caulis Spatholobi 7 parts, Herba Houttuyniae 5 parts, Herba lygodii 10 parts, Fructus Akebiae 10 parts, Rhizoma Smilacis Chinensis 7 parts, Herba Dianthi 5 parts, Fructus Toosendan 10 parts, the Radix Linderae 10 parts, Rhizoma Cyperi 7 parts, Flos Rosae Rugosae 5 parts, Cortex Cinnamomi 5 parts, Radix Aconiti Lateralis Preparata 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts of Radix Glycyrrhizae, Herba Leonuri 5 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 3 parts, Radix Salviae Miltiorrhizae 5 parts, Concha Ostreae (calcined) 5 parts。
The preparation method that the present invention also provides for a kind of Chinese medicine composition treating women chronic cystitis, with parts by weight, take Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part；Ethanol extraction, filters, and collects filtrate。
Preferably, described ethanol extraction is alcohol reflux。
Preferably, described alcohol reflux is extract crude drug 1～2 time with 50%～90% alcohol heating reflux of crude drug gross weight 6～8 times, each 60min。
The present invention also provides for a kind of Chinese medicine composition treating women chronic cystitis, the Chinese medicine composition that the preparation method described in above-mentioned any one prepares。
The present invention also provides for the application in the medicine for the treatment of women chronic cystitis of the Chinese medicine composition of the treatment women chronic cystitis described in above-mentioned any one。
The present invention also provides for a kind of Chinese medicine preparation treating women chronic cystitis, and described in the above-mentioned any one of effective dose, Chinese medicine composition and pharmaceutically acceptable adjuvant are made, and it is tablet, granule, capsule, powder, pill or oral liquid。
The invention provides a kind of Chinese medicine composition treating women chronic cystitis, this Chinese medicine composition is specifically designed for women chronic cystitis patient design, pathogeny according to chronic cystitis and clinical manifestation, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly to solve pathogenic factor, wherein Herba Houttuyniae, Herba Taraxaci, Caulis Spatholobi, Herba Andrographis, clearing away heat-fire, detoxicating, killing bacteria；Herba Dianthi, Rhizoma Smilacis Chinensis, Fructus Akebiae, Herba lygodii, inducing diuresis for treating stranguria syndrome。Select simultaneously and multiple there is very strong flavour of a drug kind targetedly and dose reduces the discomfort of sufferer, wherein Rhizoma Cyperi, Fructus Toosendan, the Radix Linderae, Flos Rosae Rugosae, promoting the circulation of QI to relieve pain。And the peculiar common body constitution according to women, relevant internal organs comprehensive measure, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly, wherein Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, enriching yin and nourishing kidney；The Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, replenishing QI to invigorate the spleen；Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Leonuri, blood-supplementing blood-nourishing is invigorated blood circulation；Radix Salviae Miltiorrhizae has nourishing YIN for decreasing fever, refrigerant dissipating blood stasis, the effect of the relieving restlessness that clears away heart-fire；Concha Ostreae (calcined) nature and flavor are salty to be slightly cold, can mind tranquilizing, can restrain again。In this Chinese medicine composition, multiple flavour of a drug compatibility comprehensive function, meets theory of Chinese medical science, improves curative effect, decrease recurrent exerbation, decrease the slight illness of female patient。Above-mentioned raw materials medicine mixed ethanol according to a certain percentage is extracted and prepares by the preparation method of Chinese medicine composition of the present invention, farthest remain the effective ingredient of each raw material, the Chinese medicine composition prepared improves the curative effect for the treatment of women chronic cystitis, decrease recurrent exerbation, decrease the slight illness of female patient。
Detailed description of the invention
In order to be further appreciated by the present invention, below in conjunction with embodiment, the preferred embodiment of the invention is described, but it is to be understood that these describe and simply further illustrate inventive feature and advantage rather than limiting to the claimed invention。
Cystitis can adopt Chinese medicine, and treating both the principal and secondary aspects of a disease is evident in efficacy, and has no side effect。Cystitis belongs to stranguria category in the traditional Chinese medical science, and Chinese medicine is thought, stranguria is many causes that functioning of bladder is unfavorable and causes because of damp-heat in the urinary bladder, asthenia of both the spleen and kidney, kidney yin loss etc.。
The invention provides a kind of Chinese medicine composition treating women chronic cystitis, be made up of the raw material of following weight portion:
Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part。
Wherein, Herba Andrographis, nature and flavor: bitter in the mouth, cold in nature；Gui Jing: GUIXIN, lung, large intestine, bladder warp；Effect: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling；Cure mainly: for cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, snake bite and insect sting。
Herba Taraxaci, nature and flavor: bitter sweet, cold；Gui Jing: enter liver, stomach warp；There is heat-clearing and toxic substances removing, effect of diuresis eliminating stagnation；Cure mainly acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection。
Caulis Spatholobi, nature and flavor: bitter, sweet, temperature；Gui Jing: return liver, kidney channel；Effect: blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral；Cure mainly for menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion。
Herba Houttuyniae: property is pungent, is slightly cold；Return lung meridian；There are heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, effect of inducing diuresis for treating stranguria syndrome；Curing mainly lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus。
Herba lygodii, nature and flavor: sweet, cold；Gui Jing: return bladder, small intestine meridian；Function: heat-clearing and toxic substances removing, relieving stranguria by diuresis；Cure mainly: control urinary tract infection, lithangiuria, nebulousurine leukorrhagia, dysuria, oedema due to nephritis, jaundice due to damp-heat, cold, fever, cough, laryngopharynx swelling and pain, enteritis, dysentery, scald, erysipelas。
Fructus Akebiae, is again " Caulis Akebiae ", " cured melon ", " YANGKAIKOU "。Nature and flavor: sweet, cold；Gui Jing: return liver,spleen,kidney warp；Effect: liver-smoothing, qi-regulating, invigorates blood circulation, eliminating stasis to stop pain, relieving restlessness diuresis；Cure mainly: for stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, menopause, and uterus drops。
Rhizoma Smilacis Chinensis, nature and flavor: sweet in the mouth, micro-hardship, puckery, property is put down；Gui Jing: return liver, kidney channel；Effect: have dampness removing to go turbid, wind expelling stagnation removing, effect of removing toxic substances dissipating blood stasis；Cure mainly: for stranguria with turbid discharge, profuse leukorrhea, rheumatic arthralgia, furuncle carbuncle。
Herba Dianthi, nature and flavor: bitter in the mouth, cold in nature；Gui Jing: GUIXIN, small intestine meridian；Function: have inducing diuresis for treating stranguria syndrome, effect of promoting blood circulation to restore menstrual flow；Cure mainly: for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenching the puckery pain of drop, the amenorrhea stasis of blood is cloudy。
Fructus Toosendan, nature and flavor: bitter, cold；Gui Jing: return liver, small intestinal, bladder warp；Effect: soothing the liver expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing；Cure mainly: for pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation。
The Radix Linderae, nature and flavor: pungent, temperature；Gui Jing: return lung, spleen, kidney, bladder warp；Effect: promoting the circulation of QI to relieve pain, warming kidney for dispelling cold。Cure mainly: for QI stagnated by cold, chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache。
Rhizoma Cyperi, nature and flavor: hardship pungent, micro-, micro-sweet are flat；Gui Jing: return liver, spleen, tri-jiao channel；Effect: dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving；Cure mainly: for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea。
Flos Rosae Rugosae, nature and flavor: hardship sweet, micro-, temperature；Gui Jing: return liver, spleen channel；Effect: promoting QI circulation for relieving depression, and blood, pain relieving。Cure mainly: for stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menstruation is not withered, and falls and flutters the pain of injury。
Cortex Cinnamomi, nature and flavor: acrid in the mouth, sweet, extremely hot in nature；Gui Jing: return kidney, spleen, the heart, Liver Channel；Function: have benefit fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, effect of promoting the flow of QI-blood by warming the meridian；Curing mainly: for sexual impotence cold womb, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, upward floating of YANG in deficiency condition, dizziness conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, and colic of cold type is suffered from abdominal pain, dysmenorrhea amenorrhea。
Radix Aconiti Lateralis Preparata, nature and flavor: acrid in the mouth, sweet, extremely hot in nature；Gui Jing: GUIXIN, kidney, spleen channel；Effect: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain；Curing mainly: collapse for YANG-depletion, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness is vomited and diarrhoea, coldness and pain in the epigastrium, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes。
The Rhizoma Atractylodis Macrocephalae, nature and flavor: bitter in the mouth, sweet, warm in nature；Gui Jing: return spleen, stomach warp；Function: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive；For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement。
Radix Glycyrrhizae, nature and flavor: sweet in the mouth, property is put down；Gui Jing: GUIXIN, lung, spleen, stomach warp；Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription；Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。
Herba Leonuri, nature and flavor: bitter, pungent, it is slightly cold；Gui Jing: return liver, pericardium, bladder warp；Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing；Cure mainly: for menoxenia, dysmenorrhea amenorrhea, lochiorrhea, edema oliguria, sore swollen toxin。In side, Herba Leonuri nature and flavor are pungent, bitter, cool, GUIXIN bag, Liver Channel。Specially entering blood system, kind blood circulation promoting and blood stasis dispelling, regulating menstruation diuretic, for the key medicine in puerperal before treatment menoxenia, tire。There is clots absorbing blood and fresh blood is not hindered, support fresh blood and the not stagnant effect of blood stasis。Uterine contraction in puerperal can be strengthened, promote that blood stasis is discharged。
Radix Rehmanniae Preparata, nature and flavor: warm in nature；Gui Jing: return liver, kidney channel；Effect: enrich blood moist；Benefit essence fills out marrow；Cure mainly: for blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, collapse that more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, menoxenia, metrostaxis, soreness of the waist and knees, Hiccough and deaf, the head be dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, dyspnea with rapid and short breath of suffering from a deficiency of the kidney。
Radix Angelicae Sinensis, nature and flavor: sweet in the mouth, pungent, warm in nature；Gui Jing: return liver, the heart, spleen channel；Effect: replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation；Cure mainly: for blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation。Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow。For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down。
Radix Salviae Miltiorrhizae, nature and flavor: bitter in the mouth, it is slightly cold；Gui Jing: GUIXIN, Liver Channel；Effect: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle；Cure mainly: for obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache。
Concha Ostreae (calcined), nature and flavor: salty, be slightly cold；Gui Jing: return liver, gallbladder, kidney channel；Effect: restrain astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, hard masses softening and resolving；Application: slip all cards (spontaneous perspiration, night sweat, frequent micturition, leukorrhagia, metrorrhagia, seminal emission etc.), pantothenic acid of having a stomachache, irritability, insomnia, excessive rising of liver-YANG, have a dizzy spell。
The invention provides a kind of Chinese medicine composition treating women chronic cystitis, this Chinese medicine composition is specifically designed for women chronic cystitis patient design, pathogeny according to chronic cystitis and clinical manifestation, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly to solve pathogenic factor, wherein Herba Houttuyniae, Herba Taraxaci, Caulis Spatholobi, Herba Andrographis, clearing away heat-fire, detoxicating, killing bacteria；Herba Dianthi, Rhizoma Smilacis Chinensis, Fructus Akebiae, Herba lygodii, inducing diuresis for treating stranguria syndrome。Select simultaneously and multiple there is very strong flavour of a drug kind targetedly and dose reduces the discomfort of sufferer, wherein Rhizoma Cyperi, Fructus Toosendan, the Radix Linderae, Flos Rosae Rugosae, promoting the circulation of QI to relieve pain。And the peculiar common body constitution according to women, relevant internal organs comprehensive measure, select and multiple there is very strong flavour of a drug kind and dose thereof targetedly, wherein Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, enriching yin and nourishing kidney；The Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, replenishing QI to invigorate the spleen；Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Leonuri, blood-supplementing blood-nourishing is invigorated blood circulation；Radix Salviae Miltiorrhizae has nourishing YIN for decreasing fever, refrigerant dissipating blood stasis, the effect of the relieving restlessness that clears away heart-fire；Concha Ostreae (calcined) nature and flavor are salty to be slightly cold, can mind tranquilizing, can restrain again。In this Chinese medicine composition, multiple flavour of a drug compatibility comprehensive function, meets theory of Chinese medical science, improves curative effect, decrease recurrent exerbation, decrease the slight illness of female patient。
In the present invention, above-mentioned whole crude drug are to well known to a person skilled in the art, it is possible to be commercially available from a medical store by commercial sources or cultivated by the method disclosed in prior art, gathering prepares, and its specification meets country or industry standard。
In one embodiment of the invention, it is preferred that Chinese medicine composition of the present invention is made up of the raw material of following weight portion:
Herba Andrographis 10 parts, Herba Taraxaci 10 parts, Caulis Spatholobi 7 parts, Herba Houttuyniae 5 parts, Herba lygodii 10 parts, Fructus Akebiae 10 parts, Rhizoma Smilacis Chinensis 7 parts, Herba Dianthi 5 parts, Fructus Toosendan 10 parts, the Radix Linderae 10 parts, Rhizoma Cyperi 7 parts, Flos Rosae Rugosae 5 parts, Cortex Cinnamomi 5 parts, Radix Aconiti Lateralis Preparata 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts of Radix Glycyrrhizae, Herba Leonuri 5 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 3 parts, Radix Salviae Miltiorrhizae 5 parts, Concha Ostreae (calcined) 5 parts。
The preparation method that present invention also offers a kind of Chinese medicine composition treating women chronic cystitis, with parts by weight, take Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part；Ethanol extraction, filters, and collects filtrate。
In one embodiment of the invention, described ethanol extraction is alcohol reflux。
In one embodiment of the invention, described alcohol reflux is extract crude drug 1～2 time with 50%～90% alcohol heating reflux of crude drug gross weight 6～8 times, each 60min。
Above-mentioned raw materials medicine mixed ethanol according to a certain percentage is extracted and prepares by the preparation method of Chinese medicine composition of the present invention, farthest remain the effective ingredient of each raw material, the Chinese medicine composition prepared improves the curative effect for the treatment of women chronic cystitis, decrease recurrent exerbation, decrease the slight illness of female patient。
Present invention also offers a kind of Chinese medicine composition treating women chronic cystitis, the Chinese medicine composition that the preparation method described in above-mentioned any one prepares。
Present invention also offers the application in the medicine for the treatment of women chronic cystitis of the Chinese medicine composition for the treatment of women chronic cystitis described in above-mentioned any one。
Present invention also offers a kind of Chinese medicine preparation treating women chronic cystitis, described in the above-mentioned any one of effective dose, Chinese medicine composition and pharmaceutically acceptable adjuvant are made, and it is tablet, granule, capsule, powder, pill or oral liquid。
The preparation of Chinese medicine composition provided by the present invention and instructions of taking: soak by water, take at twice sooner or later。It within 15 days, it is 1 course for the treatment of。
The method and apparatus of the not detailed description of the present invention is prior art, repeats no more。
In order to be further appreciated by the present invention, below in conjunction with embodiment, the present invention is described in detail, and protection scope of the present invention is not limited by the following examples。
Embodiment 1: the capsule of Chinese medicine composition of the present invention
Each raw material is weighed by following weight:
Herba Andrographis 100g, Herba Taraxaci 100g, Caulis Spatholobi 70g, Herba Houttuyniae 50g, Herba lygodii 100g, Fructus Akebiae 100g, Rhizoma Smilacis Chinensis 70g, Herba Dianthi 50g, Fructus Toosendan 100g, Radix Linderae 100g, Rhizoma Cyperi 70g, Flos Rosae Rugosae 50g, Cortex Cinnamomi 50g, Radix Aconiti Lateralis Preparata 50g, Rhizoma Atractylodis Macrocephalae 50g, Radix Glycyrrhizae 50g, Herba Leonuri 50g, Radix Rehmanniae Preparata 50g, Radix Angelicae Sinensis 30g, Radix Salviae Miltiorrhizae 50g, Concha Ostreae (calcined) 50g。
Add 80% alcohol reflux 2 times of 6 times of above-mentioned raw materials medicine gross weights, each 60min, filter, by filtrate spray drying, add Sodium Hydroxymethyl Stalcs, fully mix, make granule, load No. 1 capsule, obtain capsule。
Embodiment 2: the tablet of Chinese medicine composition of the present invention
Each raw material is weighed by following weight:
Herba Andrographis 80g, Herba Taraxaci 120g, Caulis Spatholobi 60g, Herba Houttuyniae 60g, Herba lygodii 80g, Fructus Akebiae 120g, Rhizoma Smilacis Chinensis 60g, Herba Dianthi 60g, Fructus Toosendan 80g, Radix Linderae 120g, Rhizoma Cyperi 60g, Flos Rosae Rugosae 60g, Cortex Cinnamomi 40g, Radix Aconiti Lateralis Preparata 60g, Rhizoma Atractylodis Macrocephalae 40g, Radix Glycyrrhizae 60g, Herba Leonuri 40g, Radix Rehmanniae Preparata 60g, Radix Angelicae Sinensis 20g, Radix Salviae Miltiorrhizae 60g, Concha Ostreae (calcined) 40g；
Add 60% alcohol reflux 2 times of 7 times of above-mentioned raw materials medicine gross weights, each 60min, filter, by filtrate spray drying, add Sodium Hydroxymethyl Stalcs, fully mix, send into tablet machine and make tablet。
Embodiment 3: the granule of Chinese medicine composition of the present invention
Each raw material is weighed by following weight:
Herba Andrographis 120g, Herba Taraxaci 80g, Caulis Spatholobi 60g, Herba Houttuyniae 40g, Herba lygodii 120g, Fructus Akebiae 80g, Rhizoma Smilacis Chinensis 60g, Herba Dianthi 40g, Fructus Toosendan 120g, Radix Linderae 80g, Rhizoma Cyperi 60g, Flos Rosae Rugosae 40g, Cortex Cinnamomi 40g, Radix Aconiti Lateralis Preparata 40g, Rhizoma Atractylodis Macrocephalae 40g, Radix Glycyrrhizae 40g, Herba Leonuri 40g, Radix Rehmanniae Preparata 40g, Radix Angelicae Sinensis 20g, Radix Salviae Miltiorrhizae 40g, Concha Ostreae (calcined) 40g；
Add 50% alcohol reflux 2 times of 7 times of above-mentioned raw materials medicine gross weights, each 60min, filter, by filtrate spray drying, be subsequently added into the mixture of cane sugar powder and Sodium Hydroxymethyl Stalcs, fully mix, make granule。
Embodiment 4: the pill of Chinese medicine composition of the present invention
Each raw material is weighed by following weight:
Herba Andrographis 80g, Herba Taraxaci 80g, Caulis Spatholobi 60g, Herba Houttuyniae 40g, Herba lygodii 80g, Fructus Akebiae 80g, Rhizoma Smilacis Chinensis 60g, Herba Dianthi 40g, Fructus Toosendan 80g, Radix Linderae 80g, Rhizoma Cyperi 60g, Flos Rosae Rugosae 40g, Cortex Cinnamomi 40g, Radix Aconiti Lateralis Preparata 40g, Rhizoma Atractylodis Macrocephalae 40g, Radix Glycyrrhizae 40g, Herba Leonuri 40g, Radix Rehmanniae Preparata 40g, Radix Angelicae Sinensis 20g, Radix Salviae Miltiorrhizae 40g, Concha Ostreae (calcined) 40g；
Add 90% alcohol reflux 1 time of 8 times of above-mentioned raw materials medicine gross weights, each 60min, filter, by filtrate spray drying, be subsequently added into pure Oleum sesami or Mel mixing, deliver to and centrifugal make ball machine and make pill。
Embodiment 5: the clinical trial of Chinese medicinal composition preparation of the present invention
1, subjects data
Selected from outpatient service and inpatient totally 110 example in June, 2013 in June, 2014, wherein the age is 25-65 year, average 36 years old；It is all women。
2, diagnostic criteria
2.1 symptoms: serious frequent micturition, urgent micturition, lower abdominal pain, urodynia, hematuria, weak, become thin, waist and belly and bladder perineal region is uncomfortable or dull pain etc.。
2.2 instrumental examinations: chronic cystitis is observed by cystoscope, it can be seen that neck of bladder and trigone of urinary bladder have edemous inflammation, whole bladder to present lamellar redness mucosa, and easily hemorrhage, mucosa ulcer occurs in severe patient, is sometimes covered by exudate。Inflammatory cell is invaded and mucosa and muscle layer, becomes with fibroid, makes bladder elastic and capacity reduces。
3. Therapeutic Method: soak by water, takes at twice sooner or later。It within 15 days, it is 1 course for the treatment of。
4. efficacy assessment standard
(1) cure: transference cure, and cystoscopy is without exception；
(2) effective: symptom disappears substantially or cystoscopy finds that pathological changes disappears substantially；
(3) effective: symptom alleviates or cystoscopy finds that pathological changes alleviates；
(4) invalid: symptom alleviates inconspicuous or unchanged or increases the weight of, cystoscopy finds that pathological changes is without improving or increasing the weight of。
5. clinical efficacy
Clinical cure 88 example, effective 16 examples, effective 6 examples, invalid 0 example。Cure rate is 80%, and total effective rate is 100%。
6. toxic and side effects observed result
The 110 example patients treated, it does not have any untoward reaction occurs in an example patient, and rate that sb.'s illness took a turn for the worse is 0, illustrate that human body is safe by Chinese medicine composition provided by the present invention。
7. model case
Case 1: Li schoolgirl, 28 years old。
Patient's readme: serious frequent micturition, urgent micturition, lower abdominal pain, urodynia, hematuria, weak, become thin, waist and belly and bladder perineal region is uncomfortable or dull pain, recent nocturia increases, nocturia 3-4 time。
Have a medical check-up: observed by cystoscope, it can be seen that neck of bladder and trigone of urinary bladder have edemous inflammation, whole bladder to present lamellar redness mucosa, easily hemorrhage, mucosa ulcer occur, are covered by exudate。
Diagnosis is chronic cystitis。Through taking three courses for the treatment of of medicine of the present invention, symptom alleviates, and continues to take two courses for the treatment of, cures。Follow up a case by regular visits to 1 year without recurrence。
Case 2: Mrs Wang, 40 years old。
Patient's readme: urinate discomfort, frequent micturition are felt in patient's readme in recent years, feels waist ache sometimes。Perineal position pain and twinge when urinating is felt time medical。
Having a medical check-up: observed by cystoscope, it can be seen that neck of bladder and trigone of urinary bladder have edemous inflammation, whole bladder to present lamellar redness mucosa, easily hemorrhage, inflammatory cell is invaded and mucosa and muscle layer, becomes with fibroid, makes bladder elastic and capacity reduces。
Diagnosis is chronic cystitis。Through taking two courses for the treatment of of medicine of the present invention, symptom alleviates, and continues to take two courses for the treatment of, cures。Follow up a case by regular visits to 1 year without recurrence。
Case 3: Jiang schoolgirl, 49 years old。
Patient's readme: occurred before half a year that frequent micturition, lower abdominal distention pain, the frequent soreness of waist, waist and belly and bladder perineal region be uncomfortable or dull pain, it is impossible to be sitting in the phenomenons such as office for a long time。
Having a medical check-up: observed by cystoscope, it can be seen that neck of bladder and trigone of urinary bladder have edemous inflammation, whole bladder to present lamellar redness mucosa, easily hemorrhage, inflammatory cell is invaded and mucosa and muscle layer, becomes with fibroid, makes bladder elastic and capacity reduces。
Diagnosis is chronic cystitis。Through taking two courses for the treatment of of medicine of the present invention, symptom alleviates, and continues to take 1 course for the treatment of, cures。Follow up a case by regular visits to 1 year without recurrence。
The explanation of above example is only intended to help to understand method and the core concept thereof of the present invention。It should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention, it is also possible to the present invention carries out some improvement and modification, these improve and modify in the protection domain also falling into the claims in the present invention。
Described above to the disclosed embodiments, makes professional and technical personnel in the field be capable of or uses the present invention。Multiple amendment for these embodiments is apparent from for those skilled in the art, and generic principles defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments。Therefore, the present invention is not intended to be limited to the embodiments shown herein, and is to fit to the widest range consistent with principles disclosed herein and features of novelty。

Claims (8)

1. the Chinese medicine composition treating women chronic cystitis, it is characterised in that be made up of the raw material of following weight portion:
Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part。
2. Chinese medicine composition according to claim 1, it is characterised in that be made up of the raw material of following weight portion:
Herba Andrographis 10 parts, Herba Taraxaci 10 parts, Caulis Spatholobi 7 parts, Herba Houttuyniae 5 parts, Herba lygodii 10 parts, Fructus Akebiae 10 parts, Rhizoma Smilacis Chinensis 7 parts, Herba Dianthi 5 parts, Fructus Toosendan 10 parts, the Radix Linderae 10 parts, Rhizoma Cyperi 7 parts, Flos Rosae Rugosae 5 parts, Cortex Cinnamomi 5 parts, Radix Aconiti Lateralis Preparata 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts of Radix Glycyrrhizae, Herba Leonuri 5 parts, Radix Rehmanniae Preparata 5 parts, Radix Angelicae Sinensis 3 parts, Radix Salviae Miltiorrhizae 5 parts, Concha Ostreae (calcined) 5 parts。
3. the preparation method of the Chinese medicine composition treating women chronic cystitis, it is characterized in that, with parts by weight, take Herba Andrographis 8-12 part, Herba Taraxaci 8-12 part, Caulis Spatholobi 6-8 part, Herba Houttuyniae 4-6 part, Herba lygodii 8-12 part, Fructus Akebiae 8-12 part, Rhizoma Smilacis Chinensis 6-8 part, Herba Dianthi 4-6 part, Fructus Toosendan 8-12 part, Radix Linderae 8-12 part, Rhizoma Cyperi 6-8 part, Flos Rosae Rugosae 4-6 part, Cortex Cinnamomi 4-6 part, Radix Aconiti Lateralis Preparata 4-6 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Glycyrrhizae 4-6 part, Herba Leonuri 4-6 part, Radix Rehmanniae Preparata 4-6 part, Radix Angelicae Sinensis 2-4 part, Radix Salviae Miltiorrhizae 4-6 part, Concha Ostreae (calcined) 4-6 part；Ethanol extraction, filters, and collects filtrate。
4. preparation method according to claim 3, it is characterised in that described ethanol extraction is alcohol reflux。
5. preparation method according to claim 4, it is characterised in that described alcohol reflux is extract crude drug 1～2 time with 50%～90% alcohol heating reflux of crude drug gross weight 6～8 times, each 60min。
6. the Chinese medicine composition treating women chronic cystitis, it is characterised in that the Chinese medicine composition that the preparation method described in claim 3～5 prepares。
7. the Chinese medicine composition of the treatment women chronic cystitis described in claim 1,2 or 6 any one application in the medicine for the treatment of women chronic cystitis。
8. the Chinese medicine preparation treating women chronic cystitis, it is characterised in that Chinese medicine composition and pharmaceutically acceptable adjuvant are made described in the claim 1,2 or 6 of effective dose, and it is tablet, granule, capsule, powder, pill or oral liquid。
CN201610134561.XA 2016-03-09 2016-03-09 Traditional Chinese medicine composition for treating female chronic urocystitis and preparation method of traditional Chinese medicine composition Pending CN105687936A (en)

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Application publication date: 20160622