CN105687392A - Blood-activating and collateral-dredging wine and preparation method thereof - Google Patents

Abstract

The invention discloses blood-activating and collateral-dredging wine. The blood-activating and collateral-dredging wine is prepared from pawpaw, suberect spatholobus stem, teasel root, Indian madder, whole worm, bark of eucommia, sea horse, pseudo-ginseng, long-noded pit viper, saussurea involucrate, and Baijiu according to certain weight ratio. The blood-activating and collateral-dredging wine has the advantages that the wine carries medicines to the focus of infection by utilizing the activity and warm property; by adopting the traditional Chinese medicine formula of activating blood, dispelling wind, dredging collaterals and removing dampness, the treatment effect is obvious according to the syndrome differentiation and treatment.

Description

A kind of Wine and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicinal liquor treating femur head necrosis, be specifically related to a kind of Wine, the preparation method that the invention still further relates to this Wine。

Background technology

Femur head necrosis is also known as ischemic necrosis of femoral head, for one of common osteoarthritis, most of causes because of illness such as rheumatism, hematopathy, wound, burns, long-term steroid medicine, excessive excessive drinkings etc., first destroy the blood supply closing on articular surface tissue, in turn result in necrosis。The cause of disease causing femur head necrosis has 1, now relatively common have traumatic: femoral head intracapsular fracture, fracture of femoral neck, dislocation of hip joint, fracture of acetabulum, femoral head compression fracture, hip joint bruise etc.。2, because Long-term Hormone medicine causes femur head necrosis, tracheitis, asthma, rheumatism, rheumatoid, dermatosis, anaphylactoid purpura, often eating poultry such as using the chicken of hormone nursing, pig, duck, contained by it, hormone amount is all significantly high。3, because of long-term alcohol, making ethanol stimulate and cause femur head necrosis, cause ethanol gathering in vivo to cause blood fat to increase and liver function injury, thus make blood vessel blockage, hemorrhage or fat embolism causes ischemic necrosis of femoral head。4, the femur head necrosis caused because wind and cold is wet forms osteomyelitis disease, and the common hip arthralgia, cold-damp is very, difficulty of squatting down。5, caused by liver and kidney deficiency, causes femur head necrosis；Hepatic and renal function is critically important, youngster early whitening of hair, mainly Liver and kidney blood deficiency, and ethanol also leads to caused by liver and kidney deficiency, yin asthenia generating intrinsic heat, and it shows afternoon low grade fever pain has and determines place, become thin, night sweat, weak, ache, it is impossible to easily fracture of bearing a heavy burden, often sway one's hips etc.。

The paathogenic factor of femur head necrosis atraumatic can be divided into four direction: 1, Long-term Hormone, constitutes about the 43% of total number of persons；2, crapulent accounting rural area is higher than city；3, decompression sickness: diving operation, aircrew, under high-pressure situations, blood flow and the nitrogen dissolved in tissue increase, and the excess nitrogen dissolved needs to discharge through pulmonary gradually。If pressure reduces too fast, nitrogen has little time to discharge, and namely dissociating in vivo out forms bubble, produces gas embolism；Gas embolism is at blood vessel, and blood flow is obstructed, femoral head local blood forms ischemia for being deteriorated, and promotes femur head necrosis；4, also suffering from hypertension, diabetes, arteriosclerosis, obesity, gout, radiotherapy, contusion etc. all can cause femur head necrosis。

The clinical symptoms of femur head necrosis mainly has: 1, pain feature: after suffering from femur head necrosis, and the initial stage is pain before and after hipbone root, and especially inside thigh root, pain is its feature。Being initially intermittent pain, be rest pain later, when activity increases, pain increases the weight of, and alleviates after rest。It two is hip joint movable function obstacle。As stretched, bending, abduction, interior receipts, rotation etc.。Can not costing " cross-legged ", lower limb do not gone up by dish, then walks and occurs walking lamely, leg muscle atrophy, it is impossible to the symptom such as squat down。2, walk lamely: be one of the main clinical manifestation of femur head necrosis。The reason causing limping mainly has 3 points: pain, function limitation and suffering limb cripetura。

In currently available technology, the medicine for treating femur head necrosis takes effect slowly, therapeutic effect is inconspicuous, easily easily repeatedly, being difficult to effect a radical cure, bring great misery to patient, Chinese traditional treatment femur head necrosis has the principle of oneself, heavy then take stopgap measures, relieving the primary symptom in a chronic case, treating both the principal and secondary aspects of a disease, brings the hope of rehabilitation to femoral head patient。

Summary of the invention

It is an object of the invention to provide a kind of Wine, this Wine is with the activity of wine, warm nature band medicine reaches focus, with promoting blood circulation by removing wind dredging collateral, dehumidifying is main Chinese prescription, according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect is notable, for femur head necrosis, there is determined curative effect, safe ready, treating both the principal and secondary aspects of a disease, the feature not easily recurred, and wine, have the title of " length of hundred medicines ", by the Chinese medicine of building body with wine " molten " in the medicated wine of one, not only prepare conveniently, the property of medicine is stable, safely and effectively, and because ethanol is a kind of good semi-polarity organic solvent, the various effective ingredient of Chinese medicine are all soluble in wherein, wine assisting drug, wine helps medicine gesture to give full play to its effect, improve curative effect。

The preparation method that it is a further object of the present invention to provide this Wine。

Inventor is in clinical treatment for many years is put into practice, observe the misery that femur head necrosis is brought to patient, law of development according to this disease, and the combination principle of Chinese medicine, and by substantial amounts of clinical verification, Exploration and conclusion goes out the new formula of a kind of Wine repeatedly, the present invention selects Fructus Chaenomelis, Caulis Spatholobi, Radix Dipsaci, Radix Rubiae, Scorpio, the Cortex Eucommiae, Hippocampus, Radix Notoginseng, Agkistrodon, Herba Saussureae Involueratae, Chinese liquor is combined, these drug regimens make each efficacy of drugs produce synergism, so as to have promoting blood circulation by removing wind, effect of dredging collateral dehumidifying, it is thus possible to effectively treat femur head necrosis。

The effect of Chinese medicine of the present invention:

Wherein:

Fructus Chaenomelis: for rosaceous plant chaenomeles lagenaria Chaenomelesspeciosa(Sweet) the dry almost ripe fruit of Nakai。Nature and flavor: sour, warm。Return liver, spleen channel。Effect: relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness。Fructus Chaenomelis has the effect of good relaxing muscles and tendons and activating QI and blood in the collateral, and can dehumidify again stopping numbness pain, for controlling the key medicine of arthralgia chiefly caused by damp pathogen, spasm of muscles and vessels。It is generally used for soreness of waist and knee joint person in the majority, often and the adapted such as Os Tigris during dispelling the wind and dampness pathogens arthralgia pain。

Caulis Spatholobi: for the dry rattan of pulse family Leguminosae plant spatholobus suberectus SpatholobussuberectusDunn。Nature and flavor: bitter, sweet, temperature。Return liver, kidney channel。Effect: enrich blood, invigorates blood circulation, dredging collateral。This product promoting the circulation of blood is nourished blood, relaxing muscles and tendons and activating QI and blood in the collateral, not smooth for treatment passages through which vital energy circulates, the common medicine of channels discord disease。Controlling apoplexy numb hand and foot, quadriplegia, Chang Peiwu benefiting QI for activating blood circulation dredging collateral medicine, such as the medicine such as the Radix Astragali, Radix Pseudostellariae；Controlling numb limbs and tense tendons and the blood deficiency and yellow complexion of blood deficiency not nourishing muscle and tendon, the Radix Astragali of polygamy qi-replenishing and blood-enriching medicine, Radix Angelicae Sinensis etc. are medicinal。

Radix Dipsaci: for Dipsacaceae plant Radix Dipsaci DipsacusasperoidesC.Y.ChengetT.M.Ai(or DipsacusasperWall) dry root。Nature and flavor: bitter, pungent, tepor。Return liver, kidney channel。Effect: invigorating the liver and kidney；Bone and muscle strengthening；Blood circulation regulating；Only metrorrhagia, the Cortex Eucommiae and Radix Dipsaci all energy invigorating the liver and kidney, bone and muscle strengthening, for treating deficiency of the liver and kindey, muscles and bones is strong and arthromyodynia with the passing of time, Chang Xiangxu is for using, but the Cortex Eucommiae is double controls the sexual impotence of insufficiency of kidney-YANG, frequent micturition etc., and Radix Dipsaci can continue injured, for traumatic injury, bruise and fracture etc.。Controlling aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, carbuncle skin ulcer swells。The sweet temperature of this product is supporing yang, pungent temperature cold expelling, with controlling insufficiency of kidney-YANG, and below element deficiency and cold, have liver and kidney tonifying, strong bone strengthening, the merit of promoting blood circulation concurrently。

Radix Rubiae: for the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae RubiacordifoliaL.。Nature and flavor: bitter, cold。Return Liver Channel。Effect: removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow。For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling。Clinical practice: for the multiple hemorrhage card of bleeding due to blood-heat。Radix Rubiae cold in nature enter blood system, can cooling blood for hemostasis, and can blood stasis dispelling。The blood disorder that goes out of all bleeding due to blood-heaies all can be selected for, and the stasis of blood person that holds concurrently is especially suitable。

Scorpio: also known as Scorpio, for the dry body of Buthidae animal Scorpio ButhusmartensiiKarsch。Nature and flavor: pungent are flat；Poisonous。Return Liver Channel。Effect: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain。For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula。Clinical practice: treatment arthralgia pain, does not only have good analgesic effect, and affected part is numb also effective。This product can detoxify dissipate poison, again can removing obstruction in the collateral to relieve pain, no matter oral administration and externally, all can adapted。Often use together with Scolopendra, Bombyx Batryticatus。This product heats to 100 DEG C, and 30min, toxin can eliminate。Scorpio master enters Liver Channel, can calm down liver-wind, searches again wind and removing obstruction in channels, has good endogenous wind stopping relieving convulsion effect, can be used for treating the spasm tic that a variety of causes causes。

The Cortex Eucommiae: for the dry bark of the Eucommiaceae plant Cortex Eucommiae (EucommiaulmoidesOliver)。Nature and flavor: sweet, temperature。Return liver, kidney, stomach warp。Effect: liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive。Compendium of Material Medica: the Cortex Eucommiae, ancient prescription only knows nourishing kidney, and only Wang Haogu speech is Liver Channel edema caused by disorder of QI medicine, and profit liver is dry, and tonifying liver is empty, sends out former times people and does not send out also。Lid liver governing tendons, kidney governing bones, it is strong that kidney fills then bone, and liver is filled then muscle and is good for, and bends and stretches utilization, comes under muscle。

Hippocampus: for the dry body of Syngnathidae animal strain line Hippocampus HippocampuskelloggiJordanetSnyder, HIPPOCAMPUS HippocampushistrixKaup, Hippocampus Kuda HippocampuskudaBleeker, hippocampus trimaculatus Leacs HippocampustrimaculatusLeach or little Hippocampus (HAIQU) HippocampusjaponicusKaup。Nature and flavor: sweet, temperature。Return liver, kidney channel。Effect: warming the kidney to invigorate YANG, mass dissipating and swelling eliminating。For sexual impotence, the enuresis, suffer from a deficiency of the kidney and breathe heavily, lump in the abdomen, injury from falling down；External treatment carbuncle furuncle。" detailed outline ": warm water is hidden, tonifying YANG road, the abdominal mass that disappears block controls furuncle swelling toxin。

Radix Notoginseng: for panax araliaceae plant Panaxnotoginseng(Burk.) dry root of F.H.Chen。Nature and flavor: hardship sweet, micro-, temperature。Return liver, stomach warp。Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain。For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling。Record in " book on Chinese herbal medicine is looked for the truth ": " Radix Notoginseng, common people only know that function is stopped blooding bitterly, hardly realize that pain then aches work because of blood stasis, and blood stops because of the deposited then blood that dissipates。Radix Notoginseng abnormal smells from the patient hardship temperature, can in its blood stasis of blood systemization "。

Agkistrodon: Agkistrodon Agkistrodonacutus(Gunther) the dry corpse of snakelet。Nature and flavor: sweet, salty, temperature；Poisonous。Return Liver Channel。Effect: dispel the wind, dredging collateral, relieving convulsion。For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil。(1) to the disease such as rheumatic arthralgia, spasm of muscles and vessels, can the medicine such as compatibility label grass, Radix Angelicae Pubescentis, Radix Clematidis with using；Control mouth eye tiltedly, aphasia, or the disease such as muscle arteries and veins contraction urgency, muscular paralysis, can with the compatibility application such as Scorpio, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, or infusing drugs in wine takes。Controlling tetanus, spasm is twitched and infantile convulsion convulsion is fainted, and the medicine such as compatibility Zaocys, Scolopendra is with using。Additionally, Agkistrodon can be used for again crazy, scabies, there is the effect of the counteracting toxic substances that dispels the wind, can with the medicine such as Zaocys, Realgar with using。

Herba Saussureae Involueratae: Compositae Genus Saussurea plant Saussurea laniceps SaussurealanicepsHand.-Mazz. and Saussurea eriocephala S.eriocephalaFranch, is used as medicine with whole herb with root。Nature and flavor: hardship sweet, micro-, temperature。Enter liver,spleen,kidney three warp。Effect: kidney invigorating and YANG supporting, regulating menstruation, hemostasis。For snow blindness, toothache, rheumatic arthritis, sexual impotence, menoxenia, metrorrhagia, leucorrhea；Wound hemorrhage is controlled in external。

The square solution of the present invention is: Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral in side, Caulis Spatholobi replenishing and activating blood, Radix Dipsaci tonifying liver and kidney and strengthening bones and muscles, Radix Rubiae cooling blood and dissolving stasis, Scorpio endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain, the above five tastes are monarch drug altogether, focus on live endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral, fundamentally nursing one's health from patient body, so-called general rule is not bitterly, channels and collaterals dredging is then ailing from removing, and Chinese medicine is thought, kidney storing essence, the raw marrow of essence, marrow is hidden among bone cavity, marrow nourishing bone, and kidney essense is sufficient, medullization is raw active, sclerotin must be supported, fundamentally nursing one's health from health, makes sufferer to eradicate。Cortex Eucommiae the liver and the kidney tonifying, Hippocampus warming the kidney to invigorate YANG, Radix Notoginseng subduing swelling and relieving pain, Agkistrodon dredging collateral relieving convulsion, Herba Saussureae Involueratae kidney invigorating and YANG supporting。Several tastes are ministerial drug altogether above, and monarch drug is not only played assosting effect by ministerial drug in drug effect, it is also possible to warming the meridian and promoting blood circulation, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. spasmolytic, it is possible to alleviate the sensation of numbness that femur head necrosis brings, pain, alleviate the sense of discomfort of patient。The activity of this prescription wine, warm nature band medicine reaches focus, and based on the Chinese prescription of promoting blood circulation by removing wind dredging collateral, dehumidifying, according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect is notable, it is possible to effectively treat femur head necrosis。

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope: Fructus Chaenomelis 40-60g, Caulis Spatholobi 20-40g, Radix Dipsaci 10-30g, Radix Rubiae 40-60g, Scorpio 10-30g, Cortex Eucommiae 20-40g, Hippocampus 10-30g, Radix Notoginseng 20-40g, Agkistrodon 1-5g, Herba Saussureae Involueratae 2-6g, Chinese liquor 4000-6000g。

Wherein it is preferably: Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g, Chinese liquor 5000g。

A kind of Wine, its preparation method is as follows:

Step one: by weight proportion of the present invention, first by Fructus Chaenomelis lyophilization at-15 DEG C, then carries out knocking pulverizing；

Step 2: by weight proportion of the present invention, Radix Dipsaci, Radix Rubiae, the Cortex Eucommiae, Radix Notoginseng are cut into the thin slice of 3 millimeters thick, Caulis Spatholobi is cut into broken section of 3 centimeter length, with complete Scorpio, Hippocampus, Agkistrodon, medicine block in complete Herba Saussureae Involueratae and step one, put into 60 degree of 10 jin of Chinese liquor together to soak 10 days, both the Wine for the treatment of femur head necrosis of the present invention。

Medicine of the present invention has warming the meridian and promoting blood circulation, effect of the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., temperature compensation Liver and kidney, and determined curative effect, safe ready, treating both the principal and secondary aspects of a disease, not easily recur, according to clinical 150 example patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the course for the treatment of total effective rate 97.3%。

Accompanying drawing explanation

Fig. 1 is Zhang's first visit normotopia femoral head X-ray in March, 2015 in period inspection figure in case one。

Fig. 2 is that in case one, Zhang treats normotopia femoral head X-ray inspection figure in July, 2015 in period。

Fig. 3 is Zhang's first visit MRI sheet inspection figure in March, 2015 in period in case one。

Fig. 4 is Zhang's first visit MRI sheet inspection figure in March, 2015 in period in case one。

Fig. 5 is Zhang's first visit MRI sheet inspection figure in March, 2015 in period in case one。

Fig. 6 is Zhang's first visit MRI sheet inspection figure in March, 2015 in period in case one。

Fig. 7 is that in case one, Zhang treats MRI sheet inspection figure in April, 2015 in period。

Fig. 8 is that in case one, Zhang treats MRI sheet inspection figure in April, 2015 in period。

Fig. 9 is that in case one, Zhang treats MRI sheet inspection figure in July, 2015 in later stage。

Figure 10 is that in case one, Zhang treats MRI sheet inspection figure in July, 2015 in later stage。

Figure 11 is fourth normotopia in April, 2015 in ill period in case two, frog leg position femoral head X-ray inspection figure。

Figure 12 is fourth treatment normotopia in October, 2015 in period in case two, frog leg position femoral head X-ray inspection figure。

Figure 13 is fourth treatment frog leg position femoral head X-ray in October, 2015 in period inspection figure in case two。

Figure 14 is fourth treatment normotopia femoral head X-ray in October, 2015 in period inspection figure in case two。

Figure 15 is poplar first visit normotopia femoral head X-ray in March, 2015 in period inspection figure in case three。

Figure 16 is poplar first visit frog leg position femoral head X-ray in March, 2015 in period inspection figure in case three。

Figure 17 is poplar treatment normotopia femoral head X-ray in August, 2015 in period inspection figure in case three。

Figure 18 is poplar treatment frog leg position femoral head X-ray in August, 2015 in period inspection figure in case three。

Detailed description of the invention

Embodiment one, Fructus Chaenomelis 40g, Caulis Spatholobi 20g, Radix Dipsaci 10g, Radix Rubiae 40g, Scorpio 10g, Cortex Eucommiae 20g, Hippocampus 10g, Radix Notoginseng 20g, Agkistrodon 1g, Herba Saussureae Involueratae 2g, Chinese liquor 4000g。

Embodiment two, Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g Chinese liquor 5000g。

Embodiment three, Fructus Chaenomelis 60g, Caulis Spatholobi 40g, Radix Dipsaci 30g, Radix Rubiae 60g, Scorpio 30g, Cortex Eucommiae 40g, hippocampus 3 0g, Radix Notoginseng 40g, Agkistrodon 5g, Herba Saussureae Involueratae 6g, Chinese liquor 6000g。

Patient is presented herein below and uses the clinical statistics data of medicine of the present invention:

One, physical data

Accepting out-patient 150 example for medical treatment, wherein male 89 example, women 61 example, M-F 1.4:1, the oldest person 73 years old, age reckling 30 years old, 47 years old mean age, the course of disease a few natural life-span to several weeks are not etc.。Every basic documents such as patient age, sex, the course of disease are essentially identical, no significant difference (P > 0.05)。

Two, diagnostic criteria

1, physical examination: general " 4 " word test, downward tenderness is positive；

2, x-ray plain film checks: hip joint P-A Cephalomatrics, breast-stroke bit slice；

3, MRI scan inspection, makes a definite diagnosis degree higher；

4, CT examination: it finds the time relatively MRI evening of femur head necrosis stove, and the attachment of interest morning CT sheet in femur head necrosis can be acted normally。CT scan is to judging that in femoral head, sclerotin change is better than MRI, and the prediction subsided after clear and definite femur head necrosis is diagnosed is significant。

Three, Therapeutic Method:

According to Medications Example two of the present invention, and the Wine that preferred preparation method is made, morning and evening day decoction being taken warmly 15ml after meal。

Four, efficacy assessment standard:

Curing: clinical subjective symptoms disappears, joint motion recovers normal, X-ray film, magnetic resonance: femoral head even density, bone trabecula marshalling, bone repair full wafer。

Take a turn for the better: clinical subjective symptoms disappears, and hip joint function recovers substantially, X-ray film, magnetic resonance: bone destruction repairs。

Invalid: clinical subjective symptoms X first checks all unchanged。

Five, therapeutic outcome statistics

Wherein: total effective rate=cure rate+improvement rate

Being shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in treatment femur head necrosis, can be effectively improved the cure rate for the treatment of, is worth in clinical practice and promotes。

Model case and curative effect:

Case one, patient Zhang, female, 40 years old, admission time 2015.3.28。

Main suit: double; two hip pain companion's limitation of activity 3 days, increases the weight of 1 day。

History of present illness: patient double; two hip pain occurred without obvious inducement before 3 days, heavily accompanied dropping time light during pain, and after rest, symptom is improved。Once arriving institute of traditional Chinese medicine to go to a doctor, the double; two hip MRI diagnosis of row is " bilateral femoral head ischemic necrosis "。The same day, double; two hip pain increased the weight of, and then to our hospital, outpatient service takes in institute with " bilateral femoral head ischemic necrosis "。Now without uncomfortable in chest nervous, without heating night sweat, element face can, dormancy can, two just adjust。

History of past illness: deny that hepatitis, typhoid fever, tuberculosis etc. infect medical history, deny diabetes, heart disease, hypertension chronic diseases and other major disease histories。Denying wound, operation and blood transfusion history, prophylactic immunization, with locality, denies the allergies of medicine and food etc.。

Personal history: be born in this locality, is longer than this locality, occupies history without other places for a long time, did not arrive epidemic-stricken area。Life housing condition can, without habits of smoking and alcohol drinking, deny other bad habits。

Menstrual history: menophania 14 years old, normal through measuring, color is scarlet, without clot。

Childbearing history: of the right age marriage and childbirth, gives birth to 2 sons, spouse and the equal body of children and is good for, and family relation is harmonious。

Family history: deny there is Inheritance medical history。

Traditional Chinese medical science prestige, news, palpation: patient suffering's face, language is strong, and breath is well-balanced, and whole skin is moist without macule, and skin is without xanthochromia, and subcutaneous muscle arteries and veins is without tortuous, and without facial hemiparalysis, order eyeball is without nebula, and neck is without goiter, scrofula, pale tongue, and tongue is few, arteries and veins rent land number。

Training check: spinal column physiological camber can, without obvious lateral bending and deformity, tenderness, mobility can；Double hip joint swells without red heat, the test of bilateral " 4 " word (+), bilateral inguinal midpoint tenderness (+), pelvic compression and separation test (-), bilateral toma's sign (-)。Double hip joint mobility: 100 ° of right lower extremity song hip, after stretch 20 °, inward turning 20 °, outward turning 35 °, abduction 30 °, interior receipts 20 °；110 ° of left lower extremity song hip, after stretch 20 °, inward turning 25 °, outward turning 40 °, abduction 30 °, interior receipts 20 °；Inside patella 1/3, bilateral quadriceps strength is 5 grades to double; two lower limb line of forces (anterior superior iliac spine is line between foot first and second toe web), bilateral extensor of the back muscular strength 5 grades, and double; two muscle tension of lower extremities are normal, and acra sensation blood fortune activity can。Remaining limb is without exception。

Auxiliary examination: 2015-03-28 institute of traditional Chinese medicine pelvis DR sheet shows: right side ischemic necrosis of femoral head。2015-03-28 institute of traditional Chinese medicine pelvis MRI sheet shows: bilateral femoral head ischemic necrosis。

Tentative diagnosis: tcm diagnosis: osteomyelitis is sick, yin asthenia generating intrinsic heat。

Western medicine diagnose: bilateral femoral head ischemic necrosis。

The dialectical foundation of traditional Chinese medical science differential diagnosis of diseases: the comprehensive four diagnostic methods, primary disease surely belongs to motherland's medical science " osteomyelitis is sick " category, and card belongs to " yin asthenia generating intrinsic heat ", patient women, and usually without habits of smoking and alcohol drinking, out-of-date delicious food, with the passing of time delicious food causes damp-heat accumulation, and venation blocks, and muscles and bones is lost and supported；Therefore blood deficiency and raw heat, heat arrogates to oneself to walk to alter, and excessive delicious food then liver-yang is flourishing, consumes impairment of YIN blood, and blood pulls the devil by the tail and forms blood stasis, stagnation of blood stasis and make the turbid interior life of expectorant, stop in phlegm retention and increase the weight of blood stasis。Cause phlegm and blood stasis, local blockage of main and collateral channels, stagnation of QI-blood, hematogenous blockage。Passages through which vital energy circulates is obstructed, therefore stagnation of QI and blood may bring about pain；Blockage of main and collateral channels causes clonic spasm of the muscle rheumatism involving the bone, then joint motion is unfavorable。The comprehensive four diagnostic methods, disease, at hip, is debated sick for osteomyelitis, the hot Dian phlegm-stasis in channels of the dialectical genus deficiency of YIN in this disease position。

Traditional Chinese medical science Differential Diagnosis: primary disease current diagnosis is clear and definite, need to differentiating mutually with flaccidity, mostly flaccidity is that wound or healthy energy virtual loss cause limbs muscle arteries and veins to relax, muscle is fat, brothers' flaccidity is soft unable and numb for feature, and clinical common lower limb flaccidity is weak, walk with difficulty, can not voluntary movement be even common。This patients symptomatic, based on the hip arthralgia, without obvious amyotrophy, the unable symptom of brothers, therefore can differentiate。

Treatment: Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g, Chinese liquor 5000g。

After Chinese liquor 60 degree 10 jin soaks 10 days, morning and evening day decoction being taken warmly 15ml after meal。

Fig. 1, Fig. 2 are X-ray inspection figure after patient treatment。

Fig. 3-Figure 10 is MRI sheet inspection figure after patient treatment。

Wherein once make the rounds of the wards record:

Patient's mind is clear, spirit can, the double; two hip of private prosecution is existing not ache, and diet is normal, and two just adjust, and sleep can。Have a medical check-up: double hip joint swells without red heat, and the bilateral femur deep tenderness of ditch emphasis alleviates, and bilateral greater trochanter percussion pain alleviates, the weak positive tested in bilateral " 4 " word, double hip joint mobility: 105 ° of right lower extremity song hip, after stretch 25 °, inward turning 20 °, outward turning 35 °, abduction 35 °, interior receipts 25 °；110 ° of left lower extremity song hip, after stretch 25 °, inward turning 25 °, outward turning 40 °, abduction 30 °, interior receipts 20 °。Doctor makes the rounds of the wards, and advises continuation application to continue to take medicated wine, close observation change of illness state。

Leave hospital situation: patient's mind is clear, spirit can, diet is normal, and two just adjust, sleep can, double; two hip pain senses of discomfort are clearly better before being relatively admitted to hospital。

Following up a case by regular visits to readme bilateral hip joint not bitterly, walking is normal, and review result is normal, according to femur head necrosis rehabilitation standard, to reach to be almost recovered。

Case two, patient's fourth, man, 48 years old, solar term of falling ill: the 6th day Summer Solstice。

Main suit: downright bad 1 year of bilateral femoral head。

History of present illness: patient is conscious pair of hip pain before 1 year, dropping during pain, and during walking with load, pain increases the weight of, after rest, symptom is improved。It is " bilateral femoral head is downright bad " by diagnosis after the People's Hospital of city row imaging examination。Once the expectant treatment such as oral drugs, Dressed plaster (specifically not quite clear), less effective voluntarily；Double; two hip pain occurs again recently, dare not be movable, anxious to our hospital, outpatient service is with " bilateral femoral head is downright bad " income institute。Now without uncomfortable in chest nervous, without heating night sweat, element face can, dormancy can, two just adjust。

History of past illness: cause fracture of pelvis in hospital of city row operative treatment (detailed process is not quite clear) because of traffic accident in 2009, denies that hepatitis, typhoid fever, tuberculosis etc. infect medical history, denies diabetes, heart disease, hypertension chronic diseases and other major disease histories。Denying other wounds, operation and blood transfusion history, prophylactic immunization, with locality, denies the allergies of medicine and food etc.。

Personal history: be born in this locality, is longer than this locality, occupies history without other places for a long time, did not arrive epidemic-stricken area。Life housing condition can, smoking of occasionally drinking, deny other bad habits。

Childbearing history: of the right age marriage and childbirth, gives birth to 2 sons, spouse and the equal body of children and is good for, and family relation is harmonious。

Family history: deny there is Inheritance medical history。

Traditional Chinese medical science prestige, news, palpation: patient's complexion is normal, language is strong, and breath is well-balanced, and whole skin is moist without macule, and skin is without xanthochromia, and subcutaneous muscle arteries and veins is without tortuous, and without facial hemiparalysis, order eyeball is without nebula, and neck is without goiter, scrofula, pale tongue, and tongue is few, slippery and rapid pulse。

Training check: spinal column physiological camber can, without obvious lateral bending and deformity, tenderness, mobility can；Double hip joint swells without red heat, the test of bilateral " 4 " word (+), bilateral inguinal midpoint tenderness (+), pelvic compression and separation test (-), bilateral toma's sign (-)。Double hip joint mobility: 105 ° of right lower extremity song hip, after stretch 30 °, inward turning 30 °, outward turning 40 °, abduction 30 °, interior receipts 30 °；100 ° of left lower extremity song hip, after stretch 20 °, inward turning 25 °, outward turning 40 °, abduction 30 °, interior receipts 20 °；Inside patella 1/3, bilateral quadriceps strength is 5 grades to double; two lower limb line of forces (anterior superior iliac spine is line between foot first and second toe web), bilateral extensor of the back muscular strength 5 grades, and double; two muscle tension of lower extremities are normal, and acra sensation blood fortune activity can。Remaining limb is without exception。

Auxiliary examination: the People's Hospital of 2015-04-22 city pelvis DR sheet shows: bilateral femoral head is downright bad。Tentative diagnosis: tcm diagnosis: osteomyelitis is sick, phlegm stagnation in collateral。Western medicine diagnose: bilateral femoral head is downright bad。

The dialectical foundation of traditional Chinese medical science differential diagnosis of diseases: the comprehensive four diagnostic methods, primary disease surely belongs to motherland's medical science " osteomyelitis is sick " category, and card belongs to " phlegm stagnation in collateral ", patient male, usually habits of smoking and alcohol drinking, out-of-date delicious food, and with the passing of time alcoholic strength causes damp-heat accumulation, and venation blocks, and muscles and bones is lost and supported；Hot arrogating to oneself to walk to alter, excessive drinking then liver-yang is flourishing, consumes impairment of YIN blood, and blood pulls the devil by the tail and forms blood stasis, stagnation of blood stasis and make the turbid interior life of expectorant, stop in phlegm retention and increase the weight of blood stasis。Cause phlegm and blood stasis, local blockage of main and collateral channels, stagnation of QI-blood, hematogenous blockage。Passages through which vital energy circulates is obstructed, therefore stagnation of QI and blood may bring about pain；Blockage of main and collateral channels causes clonic spasm of the muscle rheumatism involving the bone, then joint motion is unfavorable。The comprehensive four diagnostic methods, disease, at hip, is debated sick for osteomyelitis, dialectical genus phlegm-stasis in channels in this disease position。

Traditional Chinese medical science Differential Diagnosis: primary disease current diagnosis is clear and definite, need to differentiate mutually with flaccidity, flaccidity be mostly wound or healthy energy virtual loss cause limbs muscle arteries and veins to relax, wasting, brothers' flaccidity soft unable and numb for feature, clinical common lower limb flaccidity is weak, walk with difficulty, can not voluntary movement be even common。This patients symptomatic, based on the hip arthralgia, without obvious amyotrophy, the unable symptom of brothers, therefore can differentiate。

Treatment: oral Wine every day twice 15ml decoction being taken warmly after meal。Prescription: Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g, Chinese liquor 5000g。

60 degree of Chinese liquor 10 take after soaking 10 days。

Figure 11-Figure 14 is X-ray inspection figure before and after patient treatment。

Wherein once make the rounds of the wards record:

Patient's mind is clear, spirit can, the double; two hip pain of private prosecution alleviates, and diet is normal, and two just adjust, and sleep can。Have a medical check-up: double hip joint swells without red heat, and the bilateral femur deep tenderness of ditch emphasis alleviates, and bilateral greater trochanter percussion pain alleviates, the weak positive tested in bilateral " 4 " word, double hip joint mobility: 110 ° of right lower extremity song hip, after stretch 30 °, inward turning 30 °, outward turning 40 °, abduction 30 °, interior receipts 30 °；105 ° of left lower extremity song hip, after stretch 25 °, inward turning 25 °, outward turning 40 °, abduction 35 °, interior receipts 25 °。Bilateral quadriceps strength is 5 grades, bilateral extensor of the back muscular strength 5 grades, and double; two muscle tension of lower extremities are normal, and acra sensation blood fortune activity can。Chief physician makes the rounds of the wards, and advises and is continuing with said method treatment, close observation change of illness state。

Leave hospital situation: patient's mind is clear, spirit can, diet is normal, and two just adjust, sleep can, double; two hip pain senses of discomfort are clearly better before being relatively admitted to hospital。

Following up a case by regular visits to after leaving hospital repeatedly, the improving situation of patient, present situation is stable, painless, and film making checks normal, according to femur head necrosis rehabilitation standard, to reach to be almost recovered。

Case three, patient poplar, man, 68 years old, solar term of falling ill: the 10th day Waking of Insects (3rd solar term)。

Main suit: right hip pain 12 years, increases the weight of 5 days。

History of present illness: patient right hip pain occurred without obvious inducement before 12 years, and during walking with load, pain increases the weight of, and occurs that right lower extremity was walked lamely in nearly 8 years gradually, and after rest, symptom is slightly improved。The expectant treatments (specifically not quite clear) such as before 3 years, once diagnosis is after the examination in hospital of side in China: right femur head necrosis, once row oral drugs, acupuncture, exacerbation of symptoms over nearly 5 days, it is impossible to voluntarily, anxious to our hospital, outpatient service is with " bilateral femoral head is downright bad " income institute。Now without uncomfortable in chest nervous, without heating night sweat, element face can, dormancy can, two just adjust。

History of past illness: suffered from anaphylactoid purpura, row hormone therapy before 19 years；Hypertension medical history 10 years, the highest 170/110mmHg, the oral Drug therapy such as reserpine, Herba Apocyni veneti。Deny that hepatitis, typhoid fever, tuberculosis etc. infect medical history, deny diabetes, heart disease chronic diseases and other major disease histories。Denying having and injure blood transfusion history outward, prophylactic immunization, with locality, has streptomycin allergies, denies the allergies of food etc.。

Personal history: be born in Jining, is longer than Jining, works at sunshine, did not arrive epidemic-stricken area。Occasionally drink, smoking 30 years: 20/day, denies other bad habits。

Childbearing history: of the right age marriage and childbirth, gives birth to 2 female 1, and spouse and the equal body of children are good for, and family relation is harmonious。

Family history: deny there is Inheritance medical history。

Traditional Chinese medical science prestige, news, palpation: patient's complexion is normal, language is strong, and breath is well-balanced, and whole skin is moist without macule, and skin is without xanthochromia, and subcutaneous muscle arteries and veins is without tortuous, and without facial hemiparalysis, order eyeball is without nebula, and neck is without goiter, scrofula, pale tongue, and tongue is few, deep,thready and forceless pulse。

Training check: spinal column physiological camber can, without obvious lateral bending and deformity, mobility can；Double hip joint swells without red heat, the test of bilateral " 4 " word (+), bilateral inguinal midpoint tenderness (+), pelvic compression and separation test (+), the femoral nerve stretching test of bilateral side (+)。Right hip joint percussion pain, double hip joint mobility: 100 ° of right lower extremity song hip, after stretch 10 °, inward turning 20 °, outward turning 5 °, abduction 25 °, interior receipts 5 °；120 ° of left lower extremity song hip, after stretch 20 °, inward turning 30 °, outward turning 10 °, abduction 30 °, interior receipts 10 °；Inside patella 1/3, bilateral quadriceps strength, bilateral extensor of the back muscular strength, double; two muscle tension of lower extremities are normal for double; two lower limb line of forces (anterior superior iliac spine is line between foot first and second toe web), and acra sensation blood fortune activity can。Remaining limb is without exception。

The double; two hip DR of auxiliary examination: 2015-03-15 and double; two hip MRI sheet show: bilateral femoral head is downright bad。

Tentative diagnosis: tcm diagnosis: osteomyelitis is sick, phlegm stagnation in collateral。Western medicine diagnose: 1, bilateral femoral head ischemic necrosis, 2. hypertension。

The dialectical foundation of traditional Chinese medical science differential diagnosis of diseases: the comprehensive four diagnostic methods, primary disease surely belongs to motherland's medical science " osteomyelitis is sick " category, and card belongs to " phlegm stagnation in collateral ", patient male, usually habits of smoking and alcohol drinking, out-of-date delicious food, and with the passing of time alcoholic strength causes damp-heat accumulation, and venation blocks, and muscles and bones is lost and supported；Hot arrogating to oneself to walk to alter, excessive drinking then liver-yang is flourishing, consumes impairment of YIN blood, and blood pulls the devil by the tail and forms blood stasis, stagnation of blood stasis and make the turbid interior life of expectorant, stop in phlegm retention and increase the weight of blood stasis。Cause phlegm and blood stasis, local blockage of main and collateral channels, stagnation of QI-blood, hematogenous blockage。Passages through which vital energy circulates is obstructed, therefore stagnation of QI and blood may bring about pain；Blockage of main and collateral channels causes clonic spasm of the muscle rheumatism involving the bone, then joint motion is unfavorable。The comprehensive four diagnostic methods, disease, at hip, is debated sick for osteomyelitis, dialectical genus phlegm-stasis in channels in this disease position。

Traditional Chinese medical science Differential Diagnosis: primary disease current diagnosis is clear and definite, need to differentiate mutually with flaccidity, flaccidity be mostly wound or healthy energy virtual loss cause limbs muscle arteries and veins to relax, wasting, brothers' flaccidity soft unable and numb for feature, clinical common lower limb flaccidity is weak, walk with difficulty, can not voluntary movement be even common。This patients symptomatic, based on the hip arthralgia, without obvious amyotrophy, the unable symptom of brothers, therefore can differentiate。

Treatment: oral Wine every day twice 15ml decoction being taken warmly after meal。Prescription: Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g, Chinese liquor 5000g。

60 degree of Chinese liquor 10 take after soaking 10 days。

Figure 15-Figure 18 is X-ray inspection figure before and after patient treatment。

Wherein once make the rounds of the wards record:

Patient's mind is clear, spirit can, the double; two hip pain of private prosecution substantially alleviates, and diet is normal, and two just adjust, and sleep can。Have a medical check-up: double hip joint swells without red heat, the weak positive tested in bilateral " 4 " word, the bilateral inguinal midpoint weak positive of tenderness, the weak positive of pelvic compression and separation test, the weak positive of bilateral side femoral nerve stretching test, double hip joint mobility: 110 ° of right lower extremity song hip, after stretch 10 °, inward turning 20 °, outward turning 15 °, abduction 30 °, interior receipts 15 °；125 ° of left lower extremity song hip, after stretch 20 °, inward turning 30 °, outward turning 15 °, abduction 30 °, interior receipts 10 °。Today, chief physician made the rounds of the wards, and advises and continues to take said medicine, double hip joint part massage, close observation change of illness state。

Leave hospital situation: patient's mind is clear, spirit can, diet is normal, and two just adjust, sleep can, double; two hips are painless, it is possible to voluntarily。

Following up a case by regular visits to after leaving hospital repeatedly, the improving situation of patient, present situation is stable, painless, and film making checks normal, according to femur head necrosis rehabilitation standard, to reach to be almost recovered。

Claims (3)

1. a Wine, it is characterized in that, this Wine is made up of the medicine of following weight portion: Fructus Chaenomelis 40-60g, Caulis Spatholobi 20-40g, Radix Dipsaci 10-30g, Radix Rubiae 40-60g, Scorpio 10-30g, Cortex Eucommiae 20-40g, Hippocampus 10-30g, Radix Notoginseng 20-40g, Agkistrodon 1-5g, Herba Saussureae Involueratae 2-6g, Chinese liquor 4000-6000g。

2. Wine according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Fructus Chaenomelis 50g, Caulis Spatholobi 30g, Radix Dipsaci 20g, Radix Rubiae 50g, Scorpio 20g, Cortex Eucommiae 30g, Hippocampus 20g, Radix Notoginseng 30g, Agkistrodon 3g, Herba Saussureae Involueratae 4g, Chinese liquor 5000g。

3. the preparation method of a Wine, it is characterised in that preparation method is as follows: step one: by weight proportion of the present invention, first by Fructus Chaenomelis lyophilization at-15 DEG C, then carries out knocking pulverizing；Step 2: by weight proportion of the present invention, Radix Dipsaci, Radix Rubiae, the Cortex Eucommiae, Radix Notoginseng are cut into the thin slice of 3 millimeters thick, Caulis Spatholobi is cut into broken section of 3 centimeter length, with complete Scorpio, Hippocampus, Agkistrodon, medicine block in complete Herba Saussureae Involueratae and step one, put into 60 degree of 10 jin of Chinese liquor together to soak 10 days, both the Wine for the treatment of femur head necrosis of the present invention。