CN105663612A - 一种治疗强直性脊柱炎的中药组合物 - Google Patents

一种治疗强直性脊柱炎的中药组合物 Download PDF

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CN105663612A
CN105663612A CN201610138214.4A CN201610138214A CN105663612A CN 105663612 A CN105663612 A CN 105663612A CN 201610138214 A CN201610138214 A CN 201610138214A CN 105663612 A CN105663612 A CN 105663612A
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孙胜波
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Abstract

本发明涉及一种治疗强直性脊柱炎的中药组合物，其中药原料及重量份配比为：巴戟天10-30份、白花蛇舌草5-25份、青风藤5-20份、千年健5-25份、鹿衔草5-25份、透骨草5-25份、穿破石5-25份、老鹳草5-25份、寻骨风5-20份、柳枝5-25份、仙茅5-25份、韭菜子5-25份、雷公藤5-20份、两面针5-25份、女贞子5-25份、五加皮5-25份、刺龙牙5-25份、七角白蔹5-20份、豨莶草5-25份、钻地风5-25份、络石藤5-25份、甘草5-15份。本发明的中药组合物具有温补肝肾、强筋壮骨、活血化瘀、祛风除湿、舒筋活络、止痛消肿的功效，其治疗强直性脊柱炎疗效显著，作用可靠。

Description

一种治疗强直性脊柱炎的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医药配制品，尤其是一种治疗强直性脊柱炎的中药组合物。
背景技术
强直性脊柱炎属风湿病范畴，血清阴性脊柱关节病的一种。该病是以脊柱为主要病变的慢性病，累及骶髂关节，引起脊柱强直和纤维化，造成不同程度眼、肺、肌肉、骨骼病变，属自身免疫性疾病。多见于16-30岁青壮年，男性多见，40岁以后发病者少见。本病起病隐袭，进展缓慢，全身症状较轻。早期常有下背痛和晨起僵硬，活动后减轻，并可伴有低热、乏力、食欲减退、消瘦等症状。开始时疼痛为间歇性，数月数年后发展为持续性，以后炎性疼痛消失，脊柱由下而上部分或全部强直，出现驼背畸形。女性患者周围关节受侵犯较常见，进展较缓慢，脊柱畸形较轻。现代医学治疗应用非甾体类抗炎药及免疫制剂甚至激素，虽可缓解症状，但长期服用易造成胃黏膜损害、肝肾损害、骨髓抑制等副作用，患者往往难以耐受，停药后易反复或症状较前加重。
祖国医学认为强直性脊柱炎多由寒湿外袭，湿热浸淫，跌打损伤，瘀血阻络，气血运行不畅，或先天禀赋不足，肾精亏虚，骨脉失养所致。
根据中医理论，针对强直性脊柱炎的发病机理，采用温补肝肾、强筋壮骨、活血化瘀、祛风除湿、舒筋活络、止痛消肿的治法，进行辩证配伍组方，以达到标本兼治的目的。
发明内容
为了克服现有技术中治疗强直性脊柱炎存在停药后易反复或症状较前加重的不足，本发明提供一种配制简便、成本低、疗效显著、无副作用的治疗膝骨关节炎的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗强直性脊柱炎的中药组合物，其特征在于：其中药原料及重量份配比为：巴戟天10-30份、白花蛇舌草5-25份、青风藤5-20份、千年健5-25份、鹿衔草5-25份、透骨草5-25份、穿破石5-25份、老鹳草5-25份、寻骨风5-20份、柳枝5-25份、仙茅5-25份、韭菜子5-25份、雷公藤5-20份、两面针5-25份、女贞子5-25份、五加皮5-25份、刺龙牙5-25份、七角白蔹5-20份、豨莶草5-25份、钻地风5-25份、络石藤5-25份、甘草5-15份。
本发明的优选技术方案是：一种治疗强直性脊柱炎的中药组合物，其特征在于：其中药原料及重量份配比为：巴戟天20份、白花蛇舌草15份、青风藤10份、千年健15份、鹿衔草15份、透骨草15份、穿破石15份、老鹳草15份、寻骨风10份、柳枝15份、仙茅15份、韭菜子15份、雷公藤10份、两面针15份、女贞子15份、五加皮15份、刺龙牙15份、七角白蔹10份、豨莶草15份、钻地风15份、络石藤15份、甘草10份。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方。本发明中药组合物中：巴戟天具有补肾助阳、强筋壮骨、祛风除湿的功效；白花蛇舌草具有清热解毒、利尿消肿、活血止痛的功效；青风藤具有祛风湿、通经络、利小便的功效；千年健具有祛风湿、舒筋活络、止痛消肿的功效；鹿衔草具有补肾强骨、祛风除湿、止咳、止血的功效；透骨草具有祛风除湿、舒筋活络、活血止痛、解毒化疹的功效；穿破石具有祛风通络、清热除湿、解毒消肿的功效；老鹳草具有祛风湿、通经络、止泻痢的功效；寻骨风具有祛风除湿、活血通络、止痛的功效；柳枝具有祛风利湿、解毒消肿的功效；仙茅具有补肾助阳、益精血、强筋骨、行血消肿的功效；韭菜子具有温补肝肾、壮阳固精的功效；雷公藤具有祛风除湿、通络止痛、活血消肿、杀虫解毒的功效；两面针具有行气止痛、活血化瘀、祛风通络的功效；女贞子具有滋补肝肾、益阴养血的功效；五加皮具有祛风湿、补肝肾、强筋骨的功效；刺龙牙具有益气补肾、祛风利湿、活血止痛的功效；七角白蔹具有活血散瘀、消炎解毒、生肌长骨、除风祛湿的功效；豨莶草具有祛风除湿、通经活络、清热解毒的功效；钻地风具有舒筋活络、祛风活血的功效；络石藤具有祛风通络、凉血消肿的功效；甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效。本发明精选药物组方，其药物组分经辩证配伍，在作用上相互佐助，共奏温补肝肾、强筋壮骨、活血化瘀、祛风除湿、舒筋活络、止痛消肿的功效，对强直性脊柱炎的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证，其疗效显著可靠，药性平和，未出现毒副作用，有效率达96%，治愈率72%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗强直性脊柱炎的中药组合物，其中药原料及重量配比为：巴戟天20g、白花蛇舌草15g、青风藤10g、千年健15g、鹿衔草15g、透骨草15g、穿破石15g、老鹳草15g、寻骨风10g、柳枝15g、仙茅15g、韭菜子15g、雷公藤10g、两面针15g、女贞子15g、五加皮15g、刺龙牙15g、七角白蔹10g、豨莶草15g、钻地风15g、络石藤15g、甘草10g。
实施例2
一种治疗强直性脊柱炎的中药组合物，其中药原料及重量配比为：巴戟天15g、白花蛇舌草25g、青风藤5g、千年健20g、鹿衔草10g、透骨草25g、穿破石5g、老鹳草20g、寻骨风12g、柳枝25g、仙茅5g、韭菜子20g、雷公藤12g、两面针25g、女贞子5g、五加皮20g、刺龙牙10g、七角白蔹15g、豨莶草5g、钻地风20g、络石藤10g、甘草15g。
实施例3
一种治疗强直性脊柱炎的中药组合物，其中药原料及重量配比为：巴戟天25g、白花蛇舌草5g、青风藤15g、千年健10g、鹿衔草20g、透骨草5g、穿破石25g、老鹳草10g、寻骨风20g、柳枝5g、仙茅25g、韭菜子10g、雷公藤20g、两面针5g、女贞子25g、五加皮12g、刺龙牙20g、七角白蔹5g、豨莶草25g、钻地风10g、络石藤20g、甘草5g。
实施例4
一种治疗强直性脊柱炎的中药组合物，其中药原料及重量配比为：巴戟天10g、白花蛇舌草20g、青风藤12g、千年健25g、鹿衔草5g、透骨草20g、穿破石10g、老鹳草25g、寻骨风5g、柳枝20g、仙茅10g、韭菜子25g、雷公藤5g、两面针20g、女贞子10g、五加皮25g、刺龙牙5g、七角白蔹20g、豨莶草12g、钻地风25g、络石藤5g、甘草8g。
实施例5
一种治疗强直性脊柱炎的中药组合物，其中药原料及重量配比为：巴戟天30g、白花蛇舌草10g、青风藤20g、千年健5g、鹿衔草25g、透骨草10g、穿破石20g、老鹳草5g、寻骨风15g、柳枝10g、仙茅20g、韭菜子5g、雷公藤15g、两面针10g、女贞子20g、五加皮10g、刺龙牙25g、七角白蔹12g、豨莶草20g、钻地风5g、络石藤25g、甘草12g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：将组方的中药原料放入容器中，加冷水漫过药面，浸泡15～20分钟，再加水没过药面约6厘米，进行第一次煎煮，未沸前采用武火煎煮，沸后用文火煎煮20～30分钟；第二次煎煮，加水没过药面约4厘米，水沸后煎煮15～20分钟。两次煎煮取汁，合并。
本发明以实施例1所给出的一种治疗强直性脊柱炎的中药组合物，做临床疗效总结如下：
一、一般性资料：本中药组合物应用于临床观察病例50例，男31例，女19例，年龄15～45岁。
二、诊断标准：
(1)症状：以两骶髂关节，腰背部反复疼痛为主；
(2)体征：早、中期患者脊柱活动功能不同程度受限，晚期患者脊柱出现驼背固定，胸廓活动减少或消失；
(3)实验室检查：血沉多增快，类风湿因子多阴性，HLA-B27强阳性；
(4)X线检查：具有强直性脊柱炎和骶髂关节炎的典型结果。
三、用法用量：临床应用时，一日一剂，水煎两遍取汁约400ml，分早、晚两次空腹温服。六天为一疗程。治疗期间忌生冷辛辣刺激之物。
四、疗效标准：
1、治愈：沉僵症状消失，骶髂关节及各关节疼痛症状消失，关节肿胀消失，关节活动自如；各关节阳性体征消失，各关节生理功能恢复正常；
2、显效：沉僵症状明显好转，骶髂关节及各关节疼痛症状明显好转，关节肿胀明显好转，关节活动明显改善；各关节阳性体征明显好转，各关节功能明显恢复；
3有效：沉僵症状好转，骶髂关节及各关节疼痛症状好转，关节肿胀好转，关节活动改善；各关节阳性体征减轻，各关节功能有改善；
4、无效：沉僵症状无好转，骶髂关节及各关节疼痛症状无好转，关节肿胀无变化；各关节阳性体征无好转，各关节功能无变化。
五、治疗效果：该临床观察病例中，服药2-5个疗程，痊愈36例，随访未见复发；显效7例，有效5例，无效2例。治疗期间未发生毒副作用。
六、典型病例：
病例1：
冯某，男，29岁。自诉脊柱腰骶僵痛1年多，伴双膝、肘肿痛、不能下蹲、站立困难，弯腰翻身活动受限，行走艰难。诊见：腰脊强直状，舌淡、苔白厚腻，脉弦涩。X线显示：骶骨关节增宽。诊断为：强直性脊柱炎。服用本发明中药组合物制备的药剂2个疗程，症状明显减轻，能行走站立；继续服用2个疗程，症状完全消失，功能恢复正常，痊愈。半年后随访无复发。
病例2：
黄某，女，43岁。主诉：腰、背、颈、双髋多关节疼痛2余年，驼背畸形，颈椎、腰椎僵硬强直，活动受限，夜晚翻身困难，双腿关节酸困乏力，晨起活动后好转。诊断为：强直性脊柱炎。服用本发明中药组合物制备的药剂3个疗程，腰、颈、髋疼痛明显减轻；继续服用2个疗程，关节疼痛症状消失，痊愈。随访一年未复发。

Claims (2)

1.一种治疗强直性脊柱炎的中药组合物，其特征在于：其中药原料及重量份配比为：巴戟天10-30份、白花蛇舌草5-25份、青风藤5-20份、千年健5-25份、鹿衔草5-25份、透骨草5-25份、穿破石5-25份、老鹳草5-25份、寻骨风5-20份、柳枝5-25份、仙茅5-25份、韭菜子5-25份、雷公藤5-20份、两面针5-25份、女贞子5-25份、五加皮5-25份、刺龙牙5-25份、七角白蔹5-20份、豨莶草5-25份、钻地风5-25份、络石藤5-25份、甘草5-15份。
2.根据权利要求1所述一种治疗强直性脊柱炎的中药组合物，其特征在于：其中药原料及重量份配比为：巴戟天20份、白花蛇舌草15份、青风藤10份、千年健15份、鹿衔草15份、透骨草15份、穿破石15份、老鹳草15份、寻骨风10份、柳枝15份、仙茅15份、韭菜子15份、雷公藤10份、两面针15份、女贞子15份、五加皮15份、刺龙牙15份、七角白蔹10份、豨莶草15份、钻地风15份、络石藤15份、甘草10份。
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Publication number Priority date Publication date Assignee Title
CN114533695A (zh) * 2022-03-15 2022-05-27 佛山市第五人民医院（佛山市干部疗养院、佛山市工伤康复中心） 一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533695A (zh) * 2022-03-15 2022-05-27 佛山市第五人民医院（佛山市干部疗养院、佛山市工伤康复中心） 一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法

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