CN105617336A - Traditional Chinese medicine composition for preventing and treating avain enterohepatitis and preparation method - Google Patents

Traditional Chinese medicine composition for preventing and treating avain enterohepatitis and preparation method Download PDF

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CN105617336A
CN105617336A CN201610091383.7A CN201610091383A CN105617336A CN 105617336 A CN105617336 A CN 105617336A CN 201610091383 A CN201610091383 A CN 201610091383A CN 105617336 A CN105617336 A CN 105617336A
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herba
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chinese medicine
medicine composition
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李佃场
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating avain enterohepatitis and a preparation method. The traditional Chinese medicine composition comprises Sarcanthus scolopendrifolius Mak., pterocephalus hookeri, Pseudobulbus Calanthes Fimbriatae, nothopanax delavayi, taraxacum mongolicum, pararuellia delavayana, menyanthes trifoliata, radix codonopsis, semen coicis, winged yam rhizome, melastoma candidum root, sticky rice, twig and leaf of Tibet lyonia, eugenia jambos seed, fructtus nelumbinis nuciferae, Ventilago leiocarpa Benth, embelia parviflora, Rhodomyrtus tomentosa (Ait.) Hassk., radix achyranthis bidentatae, zingiber officinale, silybum marianum, Akebia trifoliata Koidz, pericarpium citri reticulatae viride, eucommia bark, Alectoria asiatica Du Rietz, fructus schizandrae, Lignum Aquilariae Resinatum, agrimonia pilosa and rhizoma nardostachyos. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can clear away heat and toxic materials, tonify the spleen and stop diarrhea and enhance chicken immunity and is high in cure rate, less prone to relapse, purely natural, free of toxic and side effects and low in cost.

Description

A kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis and preparation method
Technical field
The present invention relates to veterinary drug technical field, particularly to a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis and preparation method.
Background technology
Night blindness enterohepatitis is the acute Protozool diseases of one of turkey and the chicken caused by the Histomanas Meleagridis of Histomonas. This disease is infringement caecum and liver mainly, during severe infections, due to disturbance of blood circulation, causes disease Caput Gallus domesticus portion purple darkly, so also known as blackhead disease. The birds that epidemic characteristic is chicken, turkey, Carnis Coturnicis japonicae and other Galliformess is multiple. This disease is by seasonal effect, but summer, autumn occur many, and ground is raised the sickness rate of chicken scattered and is much higher than cage bird and online raising chicken group. It is mainly characterized by caecum inflammation and liver surface button-type ulcer stove. The environmental conditions such as the management condition of chicken group is bad, hen house is moist, overcrowding, ventilation not smooth, poor, the not comprehensive nutrition of insufficient light, feeding quality all can promote the popular of this disease and increase the weight of the state of an illness of this disease. This disease is often sent out in chickling, and the chicken susceptibility at 2 week old��4 monthly ages is high, incubation period 7��12d; Adult Chicken also can occur, but in inapparent infection, clinical symptoms is inconspicuous, and becomes carrier. After morbidity such as treatment not in time, M & M will substantially rise. Recovering chicken poor growth, egg production declines.
Cardinal symptom: suffer from chicken lassitude, fear of cold, subtracts food, and feather pine is random, matt. Have loose bowels, first passage of watery stools, arrange successively subsequently hemafecia, HUANGBAI(sic) colour band hemafecia, yellowish-brown just, sulfur color just, black paste feces, its excrement stench. Suffering from chicken skin cyanosis, it is blunt to show, and slow-witted vertical two wings are sagging on one side, and what have is curved in wing, in stilt walk sample gait during walking. Phase suffers from chicken stomach inanition after being ill, day by day becomes thin, and health is rolled up, and what have can touch allantoid caecum at abdominal part. Have spasm or performance of struggling before short dead of the course of disease, course of disease length dead before temperature decline, do not rise sleepingly. This sufferer chicken with desulphurization sulphur color feces and stilt walk sample gait for feature.
Generally about 17 days after infection, mortality rate peaks, and then within the 28th day, begins to decline.
My western medical treatment night blindness enterohepatitis scheme is single, and the course for the treatment of is longer, clinical effectiveness is inconspicuous, in some instances it may even be possible to therefore delay treatment, expand sick chicken range of infection. Further, prolonged application chemical synthetic drug toxic and side effects is big, drug residue is higher, and consumer eats this type of Carnis Gallus domesticus and its immunity of organisms is produced.
Chinese veterinarian thinks chicken the spleen tending to insufficiency usually, honey stomach, and digestive function is poor in addition, is susceptible to suffer from the disease such as enteritis, diarrhoea, heat-transformation in being prone to after ill to pass, and often causes liver to move, is susceptible to suffer from night blindness enterohepatitis. Other internal organs are ill also tends to cause mixed infection, endangers liver, intestinal, spleen, each internal organs of stomach. According to differentiation of disease according to pathological changes of the viscera and their analysis, experience virus attack liver, cause deficiency of heart-QI, it is impossible to presiding over the blood circulation each warp of circumfluence, YIN nourishing whole body, the long-pending raw heat of the stasis of blood, heat in blood is then withered, and of a specified duration then causes death.
Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, strengthens chicken immunity, controls difficulty in relapse after healing, and cost price is cheap, has highly important reality and clinical meaning.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese medicine composition for treating night blindness enterohepatitis, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have heat-clearing and toxic substances removing, the effect of invigorating the spleen to arrest diarrhea can benefiting vital QI and blood, strengthening chicken immunity, control difficulty in relapse after healing, cost price is cheap, the course for the treatment of is shorter, curative effect is better, and prolonged application has no drug resistance, drug residue free.
In order to realize foregoing invention purpose, the invention provides a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis, described Chinese medicine composition includes following raw medicinal material: Herba salviniae natantis, Herba pterocephali, pseudobulbus Calanthes fimbriatae, metapanax of araliaceae, Herba Taraxaci, Herb Pararuelliae delavayanae, Herba menyanthis, Radix Codonopsis, Semen Coicis, Rhizoma Dioscoreae Alatae, Radix melastomatis candidi, Oryza glutinosa, wood, Semen syzygii, Semen Caesalpiniae Minacis, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Embeliae Parviflorae, SHANGZI, Radix Achyranthis Bidentatae, Rhizoma Zingiberis Recens, Herba Silybi mariani, Fructus Akebiae, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Alectoria asiatica Du Rietz, Fructus Schisandrae Chinensis, Lignum Aquilariae Resinatum, Herba Agrimoniae and Radix Et Rhizoma Nardostachyos.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 8-16 weight portion, Herba pterocephali 3-7 weight portion, pseudobulbus Calanthes fimbriatae 4-8 weight portion, metapanax of araliaceae 10-20 weight portion, Herba Taraxaci 18-33 weight portion, Herb Pararuelliae delavayanae 12-23 weight portion, Herba menyanthis 10-20 weight portion, Radix Codonopsis 25-40 weight portion, Semen Coicis 20-37 weight portion, Rhizoma Dioscoreae Alatae 8-20 weight portion, Radix melastomatis candidi 13-25 weight portion, Oryza glutinosa 21-30 weight portion, wood 8-15 weight portion, Semen syzygii 7-15 weight portion, Semen Caesalpiniae Minacis 10-25 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 11-24 weight portion, Radix seu Caulis Embeliae Parviflorae 15-30 weight portion, SHANGZI 12-20 weight portion, Radix Achyranthis Bidentatae 25-38 weight portion, Rhizoma Zingiberis Recens 27-39 weight portion, Herba Silybi mariani 7-17 weight portion, Fructus Akebiae 15-25 weight portion, Pericarpium Citri Reticulatae Viride 15-25 weight portion, Cortex Eucommiae 15-25 weight portion, Alectoria asiatica Du Rietz 8-15 weight portion, Fructus Schisandrae Chinensis 23-36 weight portion, Lignum Aquilariae Resinatum 16-26 weight portion, Herba Agrimoniae 12-19 weight portion and Radix Et Rhizoma Nardostachyos 7-16 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 10-15 weight portion, Herba pterocephali 3-6 weight portion, pseudobulbus Calanthes fimbriatae 5-7 weight portion, metapanax of araliaceae 12-18 weight portion, Herba Taraxaci 20-30 weight portion, Herb Pararuelliae delavayanae 15-20 weight portion, Herba menyanthis 12-17 weight portion, Radix Codonopsis 27-38 weight portion, Semen Coicis 22-35 weight portion, Rhizoma Dioscoreae Alatae 10-16 weight portion, Radix melastomatis candidi 15-22 weight portion, Oryza glutinosa 23-27 weight portion, wood 9-13 weight portion, Semen syzygii 8-12 weight portion, Semen Caesalpiniae Minacis 11-22 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 13-20 weight portion, Radix seu Caulis Embeliae Parviflorae 17-26 weight portion, SHANGZI 14-18 weight portion, Radix Achyranthis Bidentatae 27-33 weight portion, Rhizoma Zingiberis Recens 29-35 weight portion, Herba Silybi mariani 9-15 weight portion, Fructus Akebiae 17-22 weight portion, Pericarpium Citri Reticulatae Viride 16-20 weight portion, Cortex Eucommiae 18-21 weight portion, Alectoria asiatica Du Rietz 9-13 weight portion, Fructus Schisandrae Chinensis 28-33 weight portion, Lignum Aquilariae Resinatum 17-24 weight portion, Herba Agrimoniae 13-18 weight portion and Radix Et Rhizoma Nardostachyos 8-14 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 10 weight portion, Herba pterocephali 6 weight portion, pseudobulbus Calanthes fimbriatae 6 weight portion, metapanax of araliaceae 15 weight portion, Herba Taraxaci 20 weight portion, Herb Pararuelliae delavayanae 18 weight portion, Herba menyanthis 15 weight portion, Radix Codonopsis 27 weight portion, Semen Coicis 22 weight portion, Rhizoma Dioscoreae Alatae 10 weight portion, Radix melastomatis candidi 20 weight portion, Oryza glutinosa 27 weight portion, wood 9 weight portions, Semen syzygii 12 weight portion, Semen Caesalpiniae Minacis 15 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 20 weight portion, Radix seu Caulis Embeliae Parviflorae 26 weight portion, SHANGZI 18 weight portion, Radix Achyranthis Bidentatae 30 weight portion, Rhizoma Zingiberis Recens 35 weight portion, Herba Silybi mariani 15 weight portion, Fructus Akebiae 22 weight portion, Pericarpium Citri Reticulatae Viride 18 weight portion, the Cortex Eucommiae 19 weight portion, Alectoria asiatica Du Rietz 10 weight portion, Fructus Schisandrae Chinensis 33 weight portion, Lignum Aquilariae Resinatum 21 weight portion, Herba Agrimoniae 13 weight portion and Radix Et Rhizoma Nardostachyos 12 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 15 weight portion, Herba pterocephali 4 weight portion, pseudobulbus Calanthes fimbriatae 5 weight portion, metapanax of araliaceae 18 weight portion, Herba Taraxaci 30 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Herba menyanthis 12 weight portion, Radix Codonopsis 38 weight portion, Semen Coicis 30 weight portion, Rhizoma Dioscoreae Alatae 16 weight portion, Radix melastomatis candidi 15 weight portion, Oryza glutinosa 25 weight portion, wood 13 weight portions, Semen syzygii 10 weight portion, Semen Caesalpiniae Minacis 22 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 13 weight portion, Radix seu Caulis Embeliae Parviflorae 17 weight portion, SHANGZI 14 weight portion, Radix Achyranthis Bidentatae 27 weight portion, Rhizoma Zingiberis Recens 29 weight portion, Herba Silybi mariani 11 weight portion, Fructus Akebiae 19 weight portion, Pericarpium Citri Reticulatae Viride 20 weight portion, the Cortex Eucommiae 18 weight portion, Alectoria asiatica Du Rietz 9 weight portion, Fructus Schisandrae Chinensis 28 weight portion, Lignum Aquilariae Resinatum 17 weight portion, Herba Agrimoniae 15 weight portion and Radix Et Rhizoma Nardostachyos 14 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 13 weight portion, Herba pterocephali 3 weight portion, pseudobulbus Calanthes fimbriatae 7 weight portion, metapanax of araliaceae 12 weight portion, Herba Taraxaci 25 weight portion, Herb Pararuelliae delavayanae 20 weight portion, Herba menyanthis 17 weight portion, Radix Codonopsis 33 weight portion, Semen Coicis 35 weight portion, Rhizoma Dioscoreae Alatae 12 weight portion, Radix melastomatis candidi 22 weight portion, Oryza glutinosa 23 weight portion, wood 11 weight portions, Semen syzygii 8 weight portion, Semen Caesalpiniae Minacis 11 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 18 weight portion, Radix seu Caulis Embeliae Parviflorae 23 weight portion, SHANGZI 16 weight portion, Radix Achyranthis Bidentatae 33 weight portion, Rhizoma Zingiberis Recens 32 weight portion, Herba Silybi mariani 9 weight portion, Fructus Akebiae 17 weight portion, Pericarpium Citri Reticulatae Viride 16 weight portion, the Cortex Eucommiae 21 weight portion, Alectoria asiatica Du Rietz 13 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Lignum Aquilariae Resinatum 24 weight portion, Herba Agrimoniae 18 weight portion and Radix Et Rhizoma Nardostachyos 8 weight portion.
In order to realize goal of the invention better, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis, when the dosage form of Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1��10 ��m of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%��95% of the quality 3��5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24��36 hours when 5 DEG C��10 DEG C, adopt percolation with the speed slowly percolation of 1��2ml per minute, collect percolate, concentrate and dry, and pulverizing 40��60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1��10 ��m of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes mixed powder 10g��20g that second step obtains, and adds propylene glycol 30g��50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g��1.5g needle-use activated carbon, is sufficiently stirred for 30��50 minutes; Decarbonization filtering; With 0.22��0.24 ��m of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
In order to realize goal of the invention better, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis, when the dosage form of Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue;
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste;
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition.
The technical scheme that the embodiment of the present invention provides has the benefit that
The pharmaceutical composition of the present invention can overcome the various defects of Chinese medicine of the prior art and Western medicine, there is the effect of heat-clearing and toxic substances removing, invigorating the spleen to arrest diarrhea, can benefiting vital QI and blood, strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill chicken, the course for the treatment of is shorter, and curative effect is better, controls difficulty in relapse after healing, have no drug resistance, prolonged application has no drug resistance, drug residue free, and cost price is cheap.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis, Chinese medicine composition includes following raw medicinal material: Herba salviniae natantis, Herba pterocephali, pseudobulbus Calanthes fimbriatae, metapanax of araliaceae, Herba Taraxaci, Herb Pararuelliae delavayanae, Herba menyanthis, Radix Codonopsis, Semen Coicis, Rhizoma Dioscoreae Alatae, Radix melastomatis candidi, Oryza glutinosa, wood, Semen syzygii, Semen Caesalpiniae Minacis, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Embeliae Parviflorae, SHANGZI, Radix Achyranthis Bidentatae, Rhizoma Zingiberis Recens, Herba Silybi mariani, Fructus Akebiae, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Alectoria asiatica Du Rietz, Fructus Schisandrae Chinensis, Lignum Aquilariae Resinatum, Herba Agrimoniae and Radix Et Rhizoma Nardostachyos.
Wherein, Herba salviniae natantis, Herba pterocephali, pseudobulbus Calanthes fimbriatae, metapanax of araliaceae, Herba Taraxaci, Herb Pararuelliae delavayanae heat-clearing and toxic substances removing; Herba menyanthis, Radix Codonopsis, Semen Coicis, Rhizoma Dioscoreae Alatae, Radix melastomatis candidi, Oryza glutinosa, wood, Semen syzygii, Semen Caesalpiniae Minacis invigorating the spleen to arrest diarrhea; Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Embeliae Parviflorae, SHANGZI, Radix Achyranthis Bidentatae are enriched blood; Rhizoma Zingiberis Recens, Herba Silybi mariani, Fructus Akebiae, Pericarpium Citri Reticulatae Viride are soothing the liver; The Cortex Eucommiae, Alectoria asiatica Du Rietz, Fructus Schisandrae Chinensis the kidney invigorating; Lignum Aquilariae Resinatum, Herba Agrimoniae, Radix Et Rhizoma Nardostachyos pain relieving.
The pharmacology of each raw medicinal material is as follows:
Herba salviniae natantis: another name fiber crops, limit dustpan duckweed, long foot are floating, centipede pasture and water, Herba Kyllingae, big fish duckweed, Ma Ping, water centipede, overflow head grass, Chinese scholartree wooden dipper, Herba Pistiae, Bao Tianma, Japanese pagodatree leaf are careless. Herb for Salviniaceae plant Japanese pagodatree leaf duckweed. Pungent; Bitter; Cold in nature. Clearing away heat and expelling pathogen in the exterior; Inducing diuresis to remove edema; Removing toxic substances. . Main anemopyretic cold; Measles without adequate eruption; Edema, pyretic stranguria, dysuria; Hematodiarrhoea; Hemorrhoid, carbuncle treats skin ulcer; Erysipelas; Parotitis, eczema; Burn and scald.
Herba pterocephali: another name ear of maize head, lion grass. Dipsacaceae wing head flower plant Radix Pterocephaili is used as medicine with whole herb with root. Hardship, cold. Clearing away heat and expelling pathogen in the exterior, clear away heart-fire removing heat from blood. For the fever that cold, fever and various epidemic febrile disease cause, dysphoria with smothery sensation in the heart, hemoptysis, spit blood, hematuria, have blood in stool.
Pseudobulbus Calanthes fimbriatae: another name nine sub-lotuses [Mount Taibai, Shaanxi]. The orchid family Calanthe plant Diffuse Coptosapelta calanthe and sword-like leave calanthe (narrow leaf calanthe), be used as medicine with pseudobulb and root. Pungent, bitter, cool. Heat-clearing and toxic substances removing, scattered silt pain relieving. For gastric ulcer, acute gastric dilatation, chronic hepatitis, lumbago, stomachache, lymphoid tuberculosis, chronic pharyngitis, toothache, sand Stranguria, amenorrhea, arthralgia, venom, traumatic injury.
Metapanax of araliaceae: another name Radix Ampelopsis delavayanae, Radix Orthosiphonis Wulfenioidis, Herba seu Radix Nothopanacis delavayi, precious Buddha's warrior attendant, Buddha's warrior attendant tree, Cold boiled chicken bone tree, fragrant rod, Cymbidium ensifolium (L.) Sw., Cornu Bovis seu Bubali orchid. Medical material Ji Yuan: for bark or the leaf of Araliaceae Nothopanax. Sweet in the mouth; Bitter; Cool in nature. Heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation. Main laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Dyspepsia; Menoxenia; Lumbago, skelalgia of rheumatism; Traumatic injury; Fracture.
Herba Taraxaci: bitter, sweet, cold. Return liver, stomach warp. Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome. For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herb Pararuelliae delavayanae: ground hide glue, Folium Ainslaea Triflorae, maggot medicine (" Yunnan Chinese herbal medicine "). The herb of oak little bud Herba Rostellulariae is liked for acanthaceous plant. Mildly bitter flavor; Pungent; Cool in nature. Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling. Main cough due to lung-heat; Laryngopharynx swelling and pain; Mumps; Scrofula; Carbuncle sore tumefacting virus; Injury and bone fracture; Trauma infection contamination
Herba menyanthis: another name Herba menyanthis. Gentianaceae Menyanthes plant Herba menyanthis, with all herbal medicine. Sweet, bitter, cold. Clearing away heat and promoting diuresis, stomach invigorating, calm the nerves. For gastritis, dyspepsia, cholecystitis, jaundice, hypertension, cardiopalmus, insomnia.
Radix Codonopsis: another name east party, platform party, the Lushui River party, mouth party. This product is the dry root of Campanulaceae Radix Codonopsis element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen. Sweet, flat. [return through] returns spleen, lung meridian. Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting. For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Semen Coicis: sweet, light is cool. [return through] returns spleen, stomach, lung meridian. Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away. For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Rhizoma Dioscoreae Alatae: another name ginseng potato, multitude hole potato, yampi, potato (" Guangzhou flora "), sole potato, chicken coop potato (" Nanning City's medicine will "), red Rhizoma Dioscoreae Alatae (" register planted by Guangxi medicine "). The tuber of potato is joined for Dioscoreaceae plant. Sweet; Micro-puckery; Flat. Spleen; Lung; Kidney channel. Invigorating the spleen to arrest diarrhea; Lung benefiting nourishing kidney; Removing toxic substances sore. Main diarrhea due to hypofunction of the spleen; Emission due to deficiency of the kidney; Leukorrhagia; Frequent micturition; Cough due to consumptive disease; Quench one's thirst; Skin infection festers; Burn.
Radix melastomatis candidi: for the root of Melastomateae plants Herba Melastomatis Candii, autumn uproots, cleans, dries, section. Sour in the mouth; Puckery; Property is put down. Invigorating the spleen to arrest diarrhea; Hemostasis and the stasis of blood. Main dyspepsia; Abdominal pain due to retention of food; Dysentery; Have blood in stool; Epistaxis; Menoxenia; Rheumatic arthralgia; Headache; Traumatic injury.
Oryza glutinosa: another name glutinous rice. Grass family Oryza glutinosa, is used as medicine with seed. Sweet, temperature. Enter spleen, stomach, lung meridian. Replenishing QI to invigorate the spleen. Cure mainly dysentery and prohibit mouth, chronic diarrhea decreased food intake, urine nebulousurine.
Wood: call ellipse fetterbush, fruitlet Vaccinium bracteatum Thunb., Bai Xinmu. Folium Rhododendri Simsii Como, with root, really, leaf is used as medicine. Sweet, sour, flat. Invigorating the spleen to arrest diarrhea, invigorates blood circulation, strong muscle.
Semen syzygii: for the seed of myrtle Jambul. Sweet in the mouth; Micro-acid; Cool in nature, return stomach; Spleen channel, spleen invigorating; Antidiarrheal. Main diarrhea due to hypofunction of the spleen;
Semen Caesalpiniae Minacis: another name FRUCTUS NELUMBINIS, Semen Nelumbinis, shell Semen Nelumbinis, belt leather Semen Nelumbinis. Aging fruit for nymphaeaceae plant lotus. During Semen Nelumbinis maturation in October, cut off the seedpod of the lotus, take out fruit and dry; Or pickup falls into the Semen Nelumbinis in mud, clean and dry. Hardship sweet, micro-, flat. Invigorating the spleen to arrest diarrhea. For chronic dysentery, inappetence.
Radix seu Caulis Verntilaginis Leiocarpae: Sinomenium acutum, car pusher enter stone, blue veins rattan. For the root of Rhamnaceae plant ventilago leiocarpa, stem. The whole year can adopt, and clean section is dried. Sweet, temperature, benefiting vital QI and blood, dispelling, collateral-activating, control deficiency of both QI and blood.
Radix seu Caulis Embeliae Parviflorae: Radix seu Caulis Embeliae Parviflorae, sieve its, Radix seu Caulis Embeliae Parviflorae, Murraya paniculata (L.) Jack., Radix Angelicae Gigatis, guarantor woman, Rhizoma Ardisiae Gigantifoliae, soil Osmanthus tragranscv.Aurantiacu, little arrow catch up with wind, rice huller screen rattan, medical material Ji Yuan: for root and the old stem of Myrsinacea plant Radix seu Caulis Embeliae Parviflorae. Bitter; Puckery; Warm in nature, liver; Kidney channel, enriches blood; Invigorate blood circulation;
SHANGZI: dried tofu. For the myrtaceous fruit of myrtle. Autumn takes mellow fruit, dries. Sweet puckery, flat. Nourish blood, hemostasis, astringing intestine to stop diarrhea.
Radix Achyranthis Bidentatae: Radix Achyranthis Bidentatae, cattle condyle knee joint, Herba Ophiorrhizae pumilae, Twotooth Achyranthes Root, Red Radix Achyranthis Bidentatae, Du's Radix Achyranthis Bidentatae, Radix Achyranthis, this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae. Winter stem and leaf withered time excavate, remove fibrous root and silt, be bundled into wisp, shine to shriveling, top is trimmed, dries. Bitter, sour, flat. Return liver, kidney channel. Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens, for the fresh rhizome of zingiber. Autumn, season in winter two excavate, and remove fibrous root and silt. Pungent, tepor. Returning lung, spleen, stomach warp, induce sweat cold expelling, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.
Herba Silybi mariani: milk thistle, Herba Silybi mariani, mouse, for the achene of feverfew Herba Silybi mariani. Bitter in the mouth; Cool in nature, clearing away heat-damp and promoting diuresis; Depressed liver-energy dispersing and function of gallbladder promoting
Fructus Akebiae: Yan Xuzi, poultry stores son, takes son, small wooden raft, covers son, Caulis Akebiae, Fructus Akebiae, and August explodes, wild hair egg, cold rice packet, wild Fructus Musae, YANGKAIKOU, beautiful stand, cured melon. For BENTONG section plant Caulis Akebiae, threeleaf akebia, white BENTONG fruit. Pluck during fruit maturation between 8��JIUYUE, dry, or dry after soaking with boiling water. Sweet, cold. Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain.
Pericarpium Citri Reticulatae Viride: Sihuaqingpi, FTUCTUS CITRI IMMATURI, Pericarpium Citri Reticulatae Viride, for the peel of the dry young fruit of rutaceae orange and variety thereof or immature fruit. It is collected from the young fruit fallen 5��June, dries, practise and claim " FTUCTUS CITRI IMMATURI " or " Pericarpium Citri Reticulatae Viride "; Gathering for 7��August green fruit, on peel, vertical profile becomes pintongs to base portion, eliminates flesh lobe, dries, and practises and claims " Sihuaqingpi ". Bitter, pungent, temperature. Returning liver, gallbladder, stomach warp, soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
The Cortex Eucommiae: another name pulls a skin, think of second, silk flosssilk wadding skin, beautiful silk skin. This product is the dry bark of the Eucommiaceae plant Cortex Eucommiae. Sweet, temperature. Return liver, kidney channel. Invigorating the liver and kidney, bone and muscle strengthening, antiabortive. For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Alectoria asiatica Du Rietz: black silk grass. Lichens Usneaceae send out platymiscium Asia tree send out be used as medicine with thallus. Light, flat. Nourishing the liver and kidney, restrains hidroschesis. For dizziness, clean, kidney deficiency and bodily weakness, seminal emission, night sweat; External is harnessed the Yellow River chickenpox.
Fructus Schisandrae Chinensis: sour, sweet, temperature. Return lung, the heart, kidney channel. Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming. For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Lignum Aquilariae Resinatum: this product is the timber that Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum contains resin. Pungent, bitter, tepor. Return spleen, stomach, kidney channel. Promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma. For chest and abdomen feeling of distension and oppression pain, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Herba Agrimoniae: another name Agrimony, Herba silenes fortunei, Indigofera pseudotinctoria, goldentop fossilia dentis mastodi, HUANGLONG tail, dry foot mattress. This product is the dry aerial parts of rosaceous plant Radix Agrimoniae. Bitter, puckery, flat. GUIXIN, Liver Channel. Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances. For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Radix Et Rhizoma Nardostachyos: another name Nardostachys chinensis Batal.. This product is Valerianaceae plant Radix Et Rhizoma Nardostachyos or the dry root and rhizome of spoon leaf Radix Et Rhizoma Nardostachyos. Acrid, sweet, warm. Return spleen, stomach warp. Regulating QI to relieve pain, relieving stagnation and activating the spleen. For distension and fullness in the abdomen, inappetence, vomiting; External treatment is had a toothache, swelling of the feet.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
Embodiments provide a kind of Chinese medicine composition for preventing and treating night blindness enterohepatitis, it is made up of the raw medicinal material of following weight: Herba salviniae natantis 10g, Herba pterocephali 6g, pseudobulbus Calanthes fimbriatae 6g, metapanax of araliaceae 15g, Herba Taraxaci 20g, Herb Pararuelliae delavayanae 18g, Herba menyanthis 15g, Radix Codonopsis 27g, Semen Coicis 22g, Rhizoma Dioscoreae Alatae 10g, Radix melastomatis candidi 20g, Oryza glutinosa 27g, wood 9g, Semen syzygii 12g, Semen Caesalpiniae Minacis 15g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Radix seu Caulis Embeliae Parviflorae 26g, SHANGZI 18g, Radix Achyranthis Bidentatae 30g, Rhizoma Zingiberis Recens 35g, Herba Silybi mariani 15g, Fructus Akebiae 22g, Pericarpium Citri Reticulatae Viride 18g, Cortex Eucommiae 19g, Alectoria asiatica Du Rietz 10g, Fructus Schisandrae Chinensis 33g, Lignum Aquilariae Resinatum 21g, Herba Agrimoniae 13g and Radix Et Rhizoma Nardostachyos 12g.
The dosage form of Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 3 ��m of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 30 hours when 9 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 50 minutes in super micron mill are put at this, the mixed powder that the micron particles of 4 ��m of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1.5g needle-use activated carbon, is sufficiently stirred for 40 minutes; Decarbonization filtering; With 0.23 ��m of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2 Chinese medicine composition 2
Embodiments provide the Chinese medicine composition for preventing and treating night blindness enterohepatitis, it is made up of the raw medicinal material of following weight: Herba salviniae natantis 15g, Herba pterocephali 4g, pseudobulbus Calanthes fimbriatae 5g, metapanax of araliaceae 18g, Herba Taraxaci 30g, Herb Pararuelliae delavayanae 15g, Herba menyanthis 12g, Radix Codonopsis 38g, Semen Coicis 30g, Rhizoma Dioscoreae Alatae 16g, Radix melastomatis candidi 15g, Oryza glutinosa 25g, wood 13g, Semen syzygii 10g, Semen Caesalpiniae Minacis 22g, Radix seu Caulis Verntilaginis Leiocarpae 13g, Radix seu Caulis Embeliae Parviflorae 17g, SHANGZI 14g, Radix Achyranthis Bidentatae 27g, Rhizoma Zingiberis Recens 29g, Herba Silybi mariani 11g, Fructus Akebiae 19g, Pericarpium Citri Reticulatae Viride 20g, Cortex Eucommiae 18g, Alectoria asiatica Du Rietz 9g, Fructus Schisandrae Chinensis 28g, Lignum Aquilariae Resinatum 17g, Herba Agrimoniae 15g and Radix Et Rhizoma Nardostachyos 14g.
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10 minutes, heating, to boiling 40 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue;
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1 times after concentration is 80% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtain filtrate after taking its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste;
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C, leaving air temp 70 DEG C, be ground into 300 orders subsequently, it is thus achieved that Powdered Chinese medicine composition.
Embodiment 3 Chinese medicine composition 3
Embodiments provide the Chinese medicine composition for preventing and treating night blindness enterohepatitis, it is made up of the raw medicinal material of following weight: Herba salviniae natantis 13g, Herba pterocephali 3g, pseudobulbus Calanthes fimbriatae 7g, metapanax of araliaceae 12g, Herba Taraxaci 25g, Herb Pararuelliae delavayanae 20g, Herba menyanthis 17g, Radix Codonopsis 33g, Semen Coicis 35g, Rhizoma Dioscoreae Alatae 12g, Radix melastomatis candidi 22g, Oryza glutinosa 23g, wood 11g, Semen syzygii 8g, Semen Caesalpiniae Minacis 11g, Radix seu Caulis Verntilaginis Leiocarpae 18g, Radix seu Caulis Embeliae Parviflorae 23g, SHANGZI 16g, Radix Achyranthis Bidentatae 33g, Rhizoma Zingiberis Recens 32g, Herba Silybi mariani 9g, Fructus Akebiae 17g, Pericarpium Citri Reticulatae Viride 16g, Cortex Eucommiae 21g, Alectoria asiatica Du Rietz 13g, Fructus Schisandrae Chinensis 30g, Lignum Aquilariae Resinatum 24g, Herba Agrimoniae 18g and Radix Et Rhizoma Nardostachyos 8g.
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 25 minutes, heating, to boiling 70 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 2 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue;
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 2 times after concentration is 90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtain filtrate after taking its supernatant liquid filtering next day, precipitate determining alcohol be 50% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste;
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 200 DEG C, leaving air temp 90 DEG C, be ground into 400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition.
The toxicity test 1 of Chinese medicine composition:
1, trial drug
Choose Herba salviniae natantis 10g, Herba pterocephali 6g, pseudobulbus Calanthes fimbriatae 6g, metapanax of araliaceae 15g, Herba Taraxaci 20g, Herb Pararuelliae delavayanae 18g, Herba menyanthis 15g, Radix Codonopsis 27g, Semen Coicis 22g, Rhizoma Dioscoreae Alatae 10g, Radix melastomatis candidi 20g, Oryza glutinosa 27g, wood 9g, Semen syzygii 12g, Semen Caesalpiniae Minacis 15g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Radix seu Caulis Embeliae Parviflorae 26g, SHANGZI 18g, Radix Achyranthis Bidentatae 30g, Rhizoma Zingiberis Recens 35g, Herba Silybi mariani 15g, Fructus Akebiae 22g, Pericarpium Citri Reticulatae Viride 18g, Cortex Eucommiae 19g, Alectoria asiatica Du Rietz 10g, Fructus Schisandrae Chinensis 33g, Lignum Aquilariae Resinatum 21g, Herba Agrimoniae 13g and Radix Et Rhizoma Nardostachyos 12g mixing, be ground into powder; To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the second filtrate; Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed. Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks. Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities. These parameters drug withdrawal also had no change after 2 weeks. 180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
The toxicity test 2 of Chinese medicine composition:
1, trial drug
Choose Herba salviniae natantis 15g, Herba pterocephali 4g, pseudobulbus Calanthes fimbriatae 5g, metapanax of araliaceae 18g, Herba Taraxaci 30g, Herb Pararuelliae delavayanae 15g, Herba menyanthis 12g, Radix Codonopsis 38g, Semen Coicis 30g, Rhizoma Dioscoreae Alatae 16g, Radix melastomatis candidi 15g, Oryza glutinosa 25g, wood 13g, Semen syzygii 10g, Semen Caesalpiniae Minacis 22g, Radix seu Caulis Verntilaginis Leiocarpae 13g, Radix seu Caulis Embeliae Parviflorae 17g, SHANGZI 14g, Radix Achyranthis Bidentatae 27g, Rhizoma Zingiberis Recens 29g, Herba Silybi mariani 11g, Fructus Akebiae 19g, Pericarpium Citri Reticulatae Viride 20g, Cortex Eucommiae 18g, Alectoria asiatica Du Rietz 9g, Fructus Schisandrae Chinensis 28g, Lignum Aquilariae Resinatum 17g, Herba Agrimoniae 15g and Radix Et Rhizoma Nardostachyos 14g mixing, be ground into powder; To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the second filtrate; Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed. Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks. Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities. These parameters drug withdrawal also had no change after 2 weeks. 180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
Clinical trial
(1) material prepares
Experimental chicken and place are chosen:
10 chicken houses selecting Changchun City are Experimental Base, randomly select 4 week old healthy chick 350, as treatment contrast test object. Separately randomly select the healthy 3 week old chickling 350 of these 10 chicken houses and be only used as prevention contrast test object.
(2) bacterial strain extracts:
Chicken that 3 infectious anemias in chicken farm, Changchun City 10 are died of illness cuts open inspection, the aseptic fresh cecal content taking disease chicken adds normal saline dilution, grind to form homogenate and make the Emulsion of 1: 5, cause of disease tissue fluid Emulsion is inoculated in special culture media 37 DEG C cultivate 72h, draw sediment bottom test tube and move to second time enrichment culture in new culture medium, so repeatedly for several times, microscopy numeration at any time, treat that culture medium inner tissue infusorian number reaches 2.5 ten thousand/mL culture fluid, put to be put in sterilization container in 4 DEG C of refrigerators and save backup.
(3) prevention contrast experiment:
The 350 of random choose 3 week old healthy chicks are randomly divided into 5 groups (matched group 1, matched group 2 and embodiment group 1, embodiment group 2, embodiment group 3,
Wherein, matched group 1 and matched group 2 use tradition chicken feed to feed chicken respectively,
Embodiment group 1 feeds tradition chicken feed, and injects the injectable powder of embodiment 1, and injectable powder adopts subcutaneous injection, each 2g, once a day, and injection 7 days continuously;
Embodiment group 2, embodiment group 3 add the Chinese medicine composition in the embodiment of the present invention 2,3 respectively in conventional feed, are added in feedstuff according to the part by weight of 1:100, feed 7 days; ,
To matched group 1 and embodiment group 1, embodiment group 2, embodiment group 3, carrying out artificial challenge and use source of disease liquid, only, observed and recorded respectively organizes sickness rate and the mortality rate of chicken to lumbar injection 0.3mL/, and result is as shown in table 1.
Table 1 preventive effect synopsis
Group Sum Artificial challenge's number Sickness rate Death toll Mortality rate Protective rate
Embodiment group 1 70 70 2.8% 0 0% 100%
Embodiment group 2 70 70 4.3% 0 0% 100%
Embodiment group 3 70 70 7.1% 1 1.4% 98.6%
Matched group 1 70 70 100% 20 28.5% 71.5%
Matched group 2 70 0 0 0 0 100%
Data from table 1: night blindness enterohepatitis disease is had obvious preventive effect by the Chinese medicine composition of the present invention.
(4) treatment contrast test:
350 the 4 week old healthy chicks that will randomly select, with source of disease liquid lumbar injection artificial challenge, after there is clinical symptoms, are randomly divided into 5 groups (treatment by Chinese herbs group 1, treatment by Chinese herbs group 2, treatment by Chinese herbs group 3, western medicine group, blank groups), use different medicine,
Wherein, treatment by Chinese herbs group 1 injects the injectable powder of embodiment 1, and injectable powder adopts subcutaneous injection, each 2g, once a day, injects 5 days continuously;
Treatment by Chinese herbs group 2 selects the Chinese medicine composition 2 of embodiment 2, is added in feedstuff according to the part by weight of 2:100, continuous 5 days;
Treatment by Chinese herbs group 3 selects the Chinese medicine composition 3 of embodiment 3, is added in feedstuff according to the part by weight of 2:100, continuous 5 days;
Western medicine group mutters ketone in the ratio accounting for feedstuff 0.04% with barking, and medicine is soluble in water, is then poured in the feedstuff weighed up by the medicinal liquid of dissolving, is sufficiently stirred for, and feeds chicken after Homogeneous phase mixing, continuous 5 days;
Blank group does not feed any medicine. Observed and recorded respectively organizes the sickness rate of broiler, cure rate and mortality rate, and result is as shown in table 2.
Recovery from illness: test chicken spirit, diet are intended to, feces recovers normal, and caecum and hepatic necrosis are repaired substantially, the inert Histomonas meleagridis of pathological tissues microscopy. Invalid: test chicken spirit diet is intended to have no improvement, blood stool is serious, a large amount of blood and cheesy thing is had in caecum, caecum mucosa has no reparation with the popularity ulcer of Submucosa and the necrosis region of liver surface, or death occurs; pathological tissues microscopy has substantial amounts of Histomonas meleagridis, rotates rapidly in original place or clock pendulum-like movement.
Table 2 therapeutic effect synopsis
Group Morbidity number Sickness rate Death toll Mortality rate Cure number Cure rate
Treatment by Chinese herbs group 1 70 100% 0 0% 70 100%
Treatment by Chinese herbs group 2 70 100% 1 1.4% 69 98.6%
Treatment by Chinese herbs group 3 70 100% 1 1.4% 69 98.6% 9 -->
Western medicine group 70 100% 11 15.7% 59 84.3%
Blank group 70 100% 55 78.6% - -
Data from table 2: night blindness enterohepatitis therapeutic effect is substantially better than western medicine group by Chinese medicine composition of the present invention, reduce mortality rate, improve cure rate.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (10)

1. the Chinese medicine composition being used for preventing and treating night blindness enterohepatitis, it is characterized in that, described Chinese medicine composition includes following raw medicinal material: Herba salviniae natantis, Herba pterocephali, pseudobulbus Calanthes fimbriatae, metapanax of araliaceae, Herba Taraxaci, Herb Pararuelliae delavayanae, Herba menyanthis, Radix Codonopsis, Semen Coicis, Rhizoma Dioscoreae Alatae, Radix melastomatis candidi, Oryza glutinosa, wood, Semen syzygii, Semen Caesalpiniae Minacis, Radix seu Caulis Verntilaginis Leiocarpae, Radix seu Caulis Embeliae Parviflorae, SHANGZI, Radix Achyranthis Bidentatae, Rhizoma Zingiberis Recens, Herba Silybi mariani, Fructus Akebiae, Pericarpium Citri Reticulatae Viride, the Cortex Eucommiae, Alectoria asiatica Du Rietz, Fructus Schisandrae Chinensis, Lignum Aquilariae Resinatum, Herba Agrimoniae and Radix Et Rhizoma Nardostachyos.
2. the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to claim 1, it is characterised in that in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 8-16 weight portion, Herba pterocephali 3-7 weight portion, pseudobulbus Calanthes fimbriatae 4-8 weight portion, metapanax of araliaceae 10-20 weight portion, Herba Taraxaci 18-33 weight portion, Herb Pararuelliae delavayanae 12-23 weight portion, Herba menyanthis 10-20 weight portion, Radix Codonopsis 25-40 weight portion, Semen Coicis 20-37 weight portion, Rhizoma Dioscoreae Alatae 8-20 weight portion, Radix melastomatis candidi 13-25 weight portion, Oryza glutinosa 21-30 weight portion, wood 8-15 weight portion, Semen syzygii 7-15 weight portion, Semen Caesalpiniae Minacis 10-25 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 11-24 weight portion, Radix seu Caulis Embeliae Parviflorae 15-30 weight portion, SHANGZI 12-20 weight portion, Radix Achyranthis Bidentatae 25-38 weight portion, Rhizoma Zingiberis Recens 27-39 weight portion, Herba Silybi mariani 7-17 weight portion, Fructus Akebiae 15-25 weight portion, Pericarpium Citri Reticulatae Viride 15-25 weight portion, Cortex Eucommiae 15-25 weight portion, Alectoria asiatica Du Rietz 8-15 weight portion, Fructus Schisandrae Chinensis 23-36 weight portion, Lignum Aquilariae Resinatum 16-26 weight portion, Herba Agrimoniae 12-19 weight portion and Radix Et Rhizoma Nardostachyos 7-16 weight portion.
3. the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to claim 1 and 2, it is characterised in that in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 10-15 weight portion, Herba pterocephali 3-6 weight portion, pseudobulbus Calanthes fimbriatae 5-7 weight portion, metapanax of araliaceae 12-18 weight portion, Herba Taraxaci 20-30 weight portion, Herb Pararuelliae delavayanae 15-20 weight portion, Herba menyanthis 12-17 weight portion, Radix Codonopsis 27-38 weight portion, Semen Coicis 22-35 weight portion, Rhizoma Dioscoreae Alatae 10-16 weight portion, Radix melastomatis candidi 15-22 weight portion, Oryza glutinosa 23-27 weight portion, wood 9-13 weight portion, Semen syzygii 8-12 weight portion, Semen Caesalpiniae Minacis 11-22 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 13-20 weight portion, Radix seu Caulis Embeliae Parviflorae 17-26 weight portion, SHANGZI 14-18 weight portion, Radix Achyranthis Bidentatae 27-33 weight portion, Rhizoma Zingiberis Recens 29-35 weight portion, Herba Silybi mariani 9-15 weight portion, Fructus Akebiae 17-22 weight portion, Pericarpium Citri Reticulatae Viride 16-20 weight portion, Cortex Eucommiae 18-21 weight portion, Alectoria asiatica Du Rietz 9-13 weight portion, Fructus Schisandrae Chinensis 28-33 weight portion, Lignum Aquilariae Resinatum 17-24 weight portion, Herba Agrimoniae 13-18 weight portion and Radix Et Rhizoma Nardostachyos 8-14 weight portion.
4. according to the arbitrary described Chinese medicine composition for preventing and treating night blindness enterohepatitis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 10 weight portion, Herba pterocephali 6 weight portion, pseudobulbus Calanthes fimbriatae 6 weight portion, metapanax of araliaceae 15 weight portion, Herba Taraxaci 20 weight portion, Herb Pararuelliae delavayanae 18 weight portion, Herba menyanthis 15 weight portion, Radix Codonopsis 27 weight portion, Semen Coicis 22 weight portion, Rhizoma Dioscoreae Alatae 10 weight portion, Radix melastomatis candidi 20 weight portion, Oryza glutinosa 27 weight portion, wood 9 weight portions, Semen syzygii 12 weight portion, Semen Caesalpiniae Minacis 15 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 20 weight portion, Radix seu Caulis Embeliae Parviflorae 26 weight portion, SHANGZI 18 weight portion, Radix Achyranthis Bidentatae 30 weight portion, Rhizoma Zingiberis Recens 35 weight portion, Herba Silybi mariani 15 weight portion, Fructus Akebiae 22 weight portion, Pericarpium Citri Reticulatae Viride 18 weight portion, the Cortex Eucommiae 19 weight portion, Alectoria asiatica Du Rietz 10 weight portion, Fructus Schisandrae Chinensis 33 weight portion, Lignum Aquilariae Resinatum 21 weight portion, Herba Agrimoniae 13 weight portion and Radix Et Rhizoma Nardostachyos 12 weight portion.
5. according to the arbitrary described Chinese medicine composition for preventing and treating night blindness enterohepatitis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 15 weight portion, Herba pterocephali 4 weight portion, pseudobulbus Calanthes fimbriatae 5 weight portion, metapanax of araliaceae 18 weight portion, Herba Taraxaci 30 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Herba menyanthis 12 weight portion, Radix Codonopsis 38 weight portion, Semen Coicis 30 weight portion, Rhizoma Dioscoreae Alatae 16 weight portion, Radix melastomatis candidi 15 weight portion, Oryza glutinosa 25 weight portion, wood 13 weight portions, Semen syzygii 10 weight portion, Semen Caesalpiniae Minacis 22 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 13 weight portion, Radix seu Caulis Embeliae Parviflorae 17 weight portion, SHANGZI 14 weight portion, Radix Achyranthis Bidentatae 27 weight portion, Rhizoma Zingiberis Recens 29 weight portion, Herba Silybi mariani 11 weight portion, Fructus Akebiae 19 weight portion, Pericarpium Citri Reticulatae Viride 20 weight portion, the Cortex Eucommiae 18 weight portion, Alectoria asiatica Du Rietz 9 weight portion, Fructus Schisandrae Chinensis 28 weight portion, Lignum Aquilariae Resinatum 17 weight portion, Herba Agrimoniae 15 weight portion and Radix Et Rhizoma Nardostachyos 14 weight portion.
6. according to the arbitrary described Chinese medicine composition for preventing and treating night blindness enterohepatitis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba salviniae natantis 13 weight portion, Herba pterocephali 3 weight portion, pseudobulbus Calanthes fimbriatae 7 weight portion, metapanax of araliaceae 12 weight portion, Herba Taraxaci 25 weight portion, Herb Pararuelliae delavayanae 20 weight portion, Herba menyanthis 17 weight portion, Radix Codonopsis 33 weight portion, Semen Coicis 35 weight portion, Rhizoma Dioscoreae Alatae 12 weight portion, Radix melastomatis candidi 22 weight portion, Oryza glutinosa 23 weight portion, wood 11 weight portions, Semen syzygii 8 weight portion, Semen Caesalpiniae Minacis 11 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 18 weight portion, Radix seu Caulis Embeliae Parviflorae 23 weight portion, SHANGZI 16 weight portion, Radix Achyranthis Bidentatae 33 weight portion, Rhizoma Zingiberis Recens 32 weight portion, Herba Silybi mariani 9 weight portion, Fructus Akebiae 17 weight portion, Pericarpium Citri Reticulatae Viride 16 weight portion, the Cortex Eucommiae 21 weight portion, Alectoria asiatica Du Rietz 13 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Lignum Aquilariae Resinatum 24 weight portion, Herba Agrimoniae 18 weight portion and Radix Et Rhizoma Nardostachyos 8 weight portion.
7. the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to any one of claim 1-6, it is characterised in that the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1��10 ��m of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%��95% of the quality 3��5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24��36 hours when 5 DEG C��10 DEG C, adopt percolation with the speed slowly percolation of 1��2ml per minute, collect percolate, concentrate and dry, and pulverizing 40��60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1��10 ��m of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes mixed powder 10g��20g that second step obtains, and adds propylene glycol 30g��50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g��1.5g needle-use activated carbon, is sufficiently stirred for 30��50 minutes; Decarbonization filtering; With 0.22��0.24 ��m of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to any one of claim 1-6, it is characterised in that the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue;
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste;
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition.
9. the preparation method of the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to any one of claim 1-8, it is characterised in that the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1��10 ��m of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%��95% of the quality 3��5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24��36 hours when 5 DEG C��10 DEG C, adopt percolation with the speed slowly percolation of 1��2ml per minute, collect percolate, concentrate and dry, and pulverizing 40��60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1��10 ��m of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 ��m of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, takes mixed powder 10g��20g that second step obtains, and adds propylene glycol 30g��50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g��1.5g needle-use activated carbon, is sufficiently stirred for 30��50 minutes; Decarbonization filtering; With 0.22��0.24 ��m of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
10. the preparation method of the Chinese medicine composition for preventing and treating night blindness enterohepatitis according to any one of claim 1-8, it is characterised in that the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue;
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste;
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition.
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