CN105617319A

CN105617319A - Preparation method of traditional Chinese medicine composition for treating acute cholecystitis

Info

Publication number: CN105617319A
Application number: CN201610026456.4A
Authority: CN
Inventors: 王成宝
Original assignee: Qingdao Huazhicao Medical Technology Co Ltd
Current assignee: Qingdao Huazhicao Medical Technology Co Ltd
Priority date: 2014-02-11
Filing date: 2014-02-11
Publication date: 2016-06-01
Also published as: CN103768570A; CN105561267A; CN105561266A; CN103768570B; CN105561268A

Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for treating acute cholecystitis, relating to the technical field of traditional Chinese medicines. Aiming at the defects of the chemotherapeutic drug for treating acute cholecystitis in the prior art that the liver toxicity is relatively large and the curative effect is poor, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials as raw materials: common andrographis herb, cape jasmine, sophora flower, canscora melastomacea, prepared rehmannia root, lily, honeysuckle, rhizoma alismatis, Chinese wolfberry, cnidium fruit, chuanxiong rhizome, angelica, dewdrop grass, white peony root, dried ginger, licorice, rhizoma cimicifugae and cassia seed. The traditional Chinese medicine composition prepared by the method disclosed by the invention has a good curative effect on treating or preventing acute cholecystitis, has few medicine side effects and has obvious clinical popularization values.

Description

A kind of method of the Chinese medicine composition preparing treatment acute cholecystitis

The application is applicant Yang Xianmei, Wang Chengbao, (denomination of invention is: a kind of Chinese medicine composition treating acute cholecystitis and preparation method thereof to pay the beautiful application for a patent for invention proposed, application number is: 201410047622X, and the applying date is: on February 11st, 2014) divisional application.

Technical field

The invention belongs to pharmaceutical technology field, a kind of method being specifically related to Chinese medicine composition preparing treatment acute cholecystitis.

Background technology

Acute cholecystitis is the gallbladder inflammation caused due to cystic duct obstruction and bacteria attack; Its typical clinical is characterized as upper right abdomen paroxysmal colic, tetanic with abdominal muscle with significantly touching a tender spot. The patient of about 95% is associated with cholelithiasis, is called calcareous cholecystitis; The patient of 5% does not merge cholelithiasis, is called non-calcareous cholecystitis. Its pathogenic factor mainly has following three kinds of reasons: 1. mechanicalness inflammation: owing to gallbladder cavity pressure raises, make gallbladder wall and mucosa pressurized ischemia cause; 2. chemical inflammatory: phospholipase acts on the lecithin in bile, produces LYSOLECITHIN SUNLECITHIN A, produces chemistry inflammation; 3., there is bacterial inflammation in bacterial inflammation: lodged in gallbladder by escherichia coli, Klebsiella, streptococcus, staphylococcus etc. Bacterial inflammation accounts for the 50%-80% of acute cholecystitis.

Acute cholecystitis cardinal symptom clinically is right hypochondrial region, Nausea and vomiting and heating. There is right hypochondrial region in patient Chang Shouxian, and shoulder back is diffused to the right, and pain is persistence, and paroxysmal is aggravated, and can be attended by Nausea and vomiting. Vomitus is Stomach duodenum content. Later stage performance heating, mostly is low grade fever, and shiver with cold, high heat are uncommon, and early stage is many without jaundice, when the concurrent inflammation of bile duct or inflammation cause portal lymph node enlargement, may occur in which jaundice. Local sign shows as patient's upper right abdomen tenderness, the patient of about 25% can touch enlargement gallbladder, patient is when deep air-breathing or cough, it is put in the finger under right rib and can contact the gallbladder of enlargement, patient can terminate suddenly air-breathing because of pain, upper right abdomen has tenderness, muscle tonus and rebound tenderness, when the inflammation that there will be full abdomen after perforation of gallbladder; General physical checkup patient may occur in which yellow sclera, has body temperature to raise, and pulse is accelerated, accelerated breathing, and blood pressure drops etc., as there is perforation of gallbladder, during increased inflammation, can show septic shock.

At present, the Western medicine for the treatment of acute cholecystitis is a lot, but most drug therapeutic effect is poor, and also treats into the shortcomings such as high, side effect is big, even affects patient health time serious. Antibiotic is better to the therapeutic effect of acute cholecystitis, but antibiotic life-time service can cause that human body produces antibiotic resistance, and its use can destroy the balance of intestinal microbial population, causes serious impact to the physical and mental health of patient. It addition, also have a lot of Chinese medicines treating acute cholecystitiss, but great majority have that therapeutic effect difference, cure rate be low and the shortcoming such as treatment cycle length. Namely the object of the invention is in that to provide a kind of effect comprehensively, the Chinese medicine composition of the treatment acute cholecystitis that clinical effectiveness is good.

The factors such as acute cholecystitis belongs to the sick category such as Chinese medicine " gallbladder-distention " " hypochondriac pain " " stomachache " " jaundice ", and its cause of disease is many and eating and drinking without temperance, disorder of emotion, overstrain are relevant. The thick greasy or unclean thing of surfeit delicious food and famine are full immoderate, and middle Jiao is held back in the raw heat heap soil or fertilizer over and around the roots of long-pending humidifying expectorant of a specified duration, so that liver and gall are lost in catharsis, thus gastral cavity side of body feeling of distension and oppression pain, nausea and vomiting; Or disorder of emotion, it to be worried angry, liver and gall dysfunction of acting as a pivot, bile is logical to drop freely, and stagnated QI transforming into fire, venation is become estranged, and then becomes hypochondriac pain, gallbladder-distention.

Making a general survey of the research direction of world's new drug, mainly research and develop single chemicals and preparation thereof, started to develop biotechnology and natural medicinal plants after the eighties before the eighties, drug research direction tends to multiformity. In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through Chinese medicine ingredients carries out the preparation that screening is extracted and/or compatibility prepares, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.

Summary of the invention

In prior art, chemicals is cured the symptoms, not the disease, and easily damage is gastrointestinal tract mucous, and poisonous side effect of medicine is big, and it is fixed that Chinese medicine then exists uncertain therapeutic efficacy, lacks relative medicine preparation. in order to overcome existing acute cholecystitis chemotherapeutic agent toxic and side effects big, it is not enough that acute cholecystitis therapeutic effect is difficult to lasting prior art, the invention provides a kind of Chinese medicine composition treating acute cholecystitis, this Chinese medicine composition good effect, side effect is little, it is mainly prepared by following raw material: Herba Andrographis 10-50 part, Fructus Gardeniae 10-20 part, Flos Sophorae 5-20 part, Luo Xing grass 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Alismatis 1-10 part, Fructus Lycii 5-15 part, Fructus Cnidii 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Dichodrae 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.

Herba Andrographis: bitter in the mouth, cold in nature. GUIXIN, lung, large intestine, bladder warp. Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling. Controlling acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom. " Jiangxi medical herbs ": clearing away heat and cooling blood, reducing swelling and alleviating pain, controls cholecystitis, bronchitis, hypertension, pertussis.

Fructus Gardeniae: sweet, bitter, cold. Return liver, gallbladder, stomach warp. Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis. Main icterohepatitis, dysentery, cholecystitis, the high heat of flu, spit blood, epistaxis, urinary tract infection, oedema due to nephritis, mastitis, acute toothache, sore and toxic, traumatic injury.

Flos Sophorae is again Chinese scholartree stamen, effect of Flos Sophorae: cooling blood for hemostasis, liver heat removing and eyesight improving, Flos Sophorae effect: control discharging fresh blood stool, hemorrhoid hematochezia, hematuria stranguria with blood, liver-heat headache, conjunctival congestion and swelling pain, Flos Sophorae medication is avoided: Deficiency and coldness of spleen and stomach person is careful takes Flos Sophorae, Flos Sophorae can (drugs) to be decocted and taken as a drink, Flos Sophorae also can be equal to use with Spica Prunellae, Flos Chrysanthemi, Radix Scutellariae, to increase the effect of purging liver-fire improving eyesight. Clinic cures mainly: discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat is had a headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.

Luo Xingcao: bitter, cold. Heat-clearing and toxic substances removing, eliminating stasis to stop pain. Cure mainly hepatitis, cholecystitis, acute enteritis, dysentery, tonsillitis, injury and bone fracture, arthralgia.

Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant, has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and the processed process of preparing Chinese medicine forms. Radix Rehmanniae Preparata is a kind of first-class Chinese crude drug, has YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, the disease such as quench one's thirst, and are one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main components. Radix Rehmanniae Preparata is first appeared in Shennong's Herbal, and Clinical practice has fresh, raw, ripe three kinds. All there is the merit of YIN nourishing and the production of body fluid promoting, and control all cards of Yin and fluid deficiency. Radix Rehmanniae sweetness and bitterness Great Cold, though the power of YIN nourishing is weak, but it is longer than clearing away heat and cooling blood, pathogenic fire purging relieving restlessness, it is used for heat in blood heresy and contains, syndrome of yin deficiency and depletion of fluid; The power of raw (do) Radix Rehmanniae sweet cold matter profit removing heat from blood is slightly inferior but is longer than the moon of the kidney that nourishes heart, Gu Xuereyin injure fever due to yin deficiency person suitable it; Radix Rehmanniae Preparata is sweet in flavor and warm in property, enters Liver and kidney and the special nourishing the blood and yin of merit, life essence-filling, marrow-benefitting, all kidney-YIN being deficient, marrow virtual loss person, all can use it. Radix Rehmanniae Preparata is used for insufficiency of kidney-YANG, decline of the fire from the gate of life, aversion to cold and cold limbs, impotence and seminal emission, and urine loses drop, or the anorexia and loose stool of YANG failing to warm spleen-YANG, many product adapteds with the warming YANG such as Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, this namely so-called " being apt to YANG invigorating person, must in treating YANG within YIN " meaning. With controlling carbuncle of yin nature cold coagulation, this product often and the adapted such as Colla cornus cervi, Cortex Cinnamomi, Herba Ephedrae with channel warming and blood nourishing, cold expelling is promoted blood circulation.

The traditional Chinese medical science thinks that Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious. Bulbus Lilii is particularly suitable for supporting lung, the people of nourishing the stomach eats, the such as patient of chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue, xerostomia, halitosis. Bulbus Lilii not only has good nutritious tonifying effect, and of great advantage for patients such as deficient syndrome after being ill, tuberculosis, neurosiss, and various cancers are had good curative effect. In the prevention and treatment of tumor, Bulbus Lilii is used for treatment pulmonary carcinoma, nasopharyngeal carcinoma, skin carcinoma etc. During the symptoms such as body void weak, xerostomia, vexed, the dry cough expectorant occurred after above-mentioned cancer is carried out radiotherapy, cook congee together with Semen oryzae sativae with fresh Bulbus Lilii, eat after calling in appropriate crystal sugar or Mel again, to health invigorating, anticancer growth, alleviate radiotherapy reaction, there is good effect. For another example, fresh Bulbus Lilii and white sugar being smash deposited affected part in right amount altogether, skin carcinoma ulceration is hemorrhage, infiltration person also has certain therapeutical effect.

Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor. It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, gastroenteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss. Flos Lonicerae tea has the weight losing function of uniqueness simultaneously, moreover it is possible to the pathogen suppressing with killing bottleneck throat, and old man and child are had infection effect. So, often take Flos Lonicerae and soak or decoct is conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the treatment of liver-heat disease regulating liver-QI pattern of fever hypertension and rehabilitation.

Rhizoma Alismatis is the tuber of Notes On Alism At Aceae Rhizoma Alismatis. Theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen. Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are additionally operable to treatment auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc. But Rhizoma Alismatis has liver toxicity, nephrotoxicity, it is improper to take, and liver, kidney can be allowed swelling and other poisoning symptoms occur.

Fructus Lycii (formal name used at school: Lyciumchinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, up to more than 2 meters during cultivation. All there is distribution both at home and abroad. Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ". Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea. Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can antiatherogenic effect.

Fructus Cnidii is the fruit of samphire cnidium monnieri. Another name: Serpentis rice, Serpentis pearl, Serpentis foxtail millet, cnidium monnieri core, cnidium monnieri reality, gas fruit, Radix Habenariae Dentatae, favus-infected head beggar, wild Fructus Foeniculi. There is warming the kidney to invigorate YANG; Removing dampness and killing parasites; Effect of dispelling wind for relieving itching. Control impotence in male; Scrotum pruritus due to damp pathogen; Woman's infertility; Cold-damp leukorrhagia; Pudendal pruritus swells and ache; Rheumatic arthralgia; Eczema scabies. The Tang Dynasty is infertile for sexual impotence and cold womb. Fructus Cnidii has the merit of warming the kidney to activate YANG, the impotence in male that treatment deficiency of kidney yin causes, and woman's cold womb is infertile, can be equal to use with Fructus Lycii, Semen Cuscutae, Fructus Schisandrae Chinensis, Cortex Cinnamomi, mends fire, supporing yang emerging flaccidity with kidney tonifying; " prescriptions worth thousand gold " controls kidney yang deficiency and coldness, the Radix Aconiti ball that sexual impotence does not rise, and namely forms with this product compatibility. For man's scrotum pruritus due to damp pathogen, woman's pudendal pruritus leukorrhagia, eczema scabies. Fructus Cnidii can dampness dispel the wind, killing parasites for relieving itching. Controlling eczema scrotum, woman's pudendal pruritus band is many, can alone or with the pan-fried soup washouts such as Radix Sophorae Flavescentis, Cortex Phellodendri, Alumen.

The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go scattered, up up to top, mountain peak; Enter again blood system, descending up to the sea of blood. Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia. It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving. The pungent temperature rise of this product dissipates, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.

The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis. Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom. Being clinically used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache. Can also be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis. Controlling headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies. Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, and for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable. Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, often apply with the compatibility such as Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae.

Herba Dichodrae: bitter, pungent, cool. Return lung, Liver Channel. Heat clearing away, dampness removing, removing toxic substances. Harness the Yellow River subcutaneous ulcer, dysentery, sand Stranguria, nebulousurine, edema, furuncle swelling toxin, traumatic injury, venom. " Chinese Plants will ": all herbal medicine has the merit of clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, parasite killing. Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis and carbuncle furuncle treat poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc.

The Radix Paeoniae Alba is traditional parts of generic medicinal plants that China is famous, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, is classified as middle product, and note has " main pathogen, the Radix Paeoniae Alba is suffered from abdominal pain, and except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ". Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant. Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, and inferior disease is with in metrorrhagia. Modern pharmacology research display, paeoniflorin is to Cavia porcellus, the intestine in vitro of rat and moves at stomach, and rat uterus smooth muscle all shows suppression, and can contraction caused by antagonism oxytocin; With acetic acid injection in mouse peritoneal, using writhing response as the index of pain, paeoniflorin has significant analgesic effect; The convulsions caused by extractum energy antagonism strychnine of Radix Paeoniae; Dysentery bacterium is in vitro had bacteriostasis by Radix Paeoniae Alba decoct, and some pathogenic fungus is also had inhibitory action by preserved material. White mice normal body temperature is had cooling effect by paeoniflorin, and the mice of artificial fever is also had refrigeration function. Rat Experimental metapedes sole of the foot edema there is antiinflammatory action; The rat platelet aggregation of adenosine diphosphate (ADP) induction in vitro or is had inhibitory action during intravenous injection by paeoniflorin; The digestive tract in rats ulcer brought out owing to anxiety irritates is had obvious inhibitory action by paeoniflorin.

Rhizoma Zingiberis Shennong's Herbal is classified as middle product, and Rhizoma Zingiberis Recens " Mingyi Bielu " is classified as middle product. TAO Hong-Jing is called: " all making Rhizoma Zingiberis method: water logging three days, peeling is put in flowing water six, and then more random peeling is dried, put in Porcelain Jar and make three, be into. " Li Shizhen (1518-1593 A.D.) meaning Rhizoma Zingiberis makes it with female Rhizoma Zingiberis Recens, with fair and clear solid person for good, all it is used as medicine and Yi Pao use. Rhizoma Zingiberis is used for warming up spleen sun, partially controls spleen-cold syndrome stomachache and has loose bowels. Promoting blood circulation by recuperating depleted YANG again, warming the lung to resolve fluid-retention, with controlling yang depletion syndrome, four cold of the limbs are inverse, faint pulse being about to disappear, and cold fluid-retention cough with asthma, and the cold physique back of the body is cold, the clear rare disease such as grade of abundant expectoration.

Chinese medicine composition of the present invention to remove long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening for main standard, has significant antiinflammatory, analgesia and activating blood circulation to dissipate blood stasis effect after Chinese medicine composition of the present invention combination on Chinese medicinal components selects. The parts by weight of above-mentioned all taste Chinese medicine have been carried out preferably by the present invention, it is preferred that condition is the medicine enhancing to acute cholecystitis therapeutic effect after Chinese medicine and western medicine compatibility uses. As a preferred embodiment of the present invention, Chinese medicine composition of the present invention is mainly prepared by the raw material of following weight portion: Herba Andrographis 30 parts, Fructus Gardeniae 15 parts, 15 parts of Flos Sophorae, Luo Xing grass 10 parts, 8 parts of Radix Rehmanniae Preparata, Bulbus Lilii 10 parts, Flos Lonicerae 10 parts, Rhizoma Alismatis 6 parts, Fructus Lycii 10 parts, Fructus Cnidii 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Dichodrae 5.5 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Zingiberis 8 parts, 12 parts of Radix Glycyrrhizae.

Preferably, the Chinese medicine composition of the present invention also contains Rhizoma Cimicifugae 5 parts, Semen Cassiae 9 parts further. Rhizoma Cimicifugae is the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae. Another name: all Rhizoma Cimicifugae, Os Gallus domesticus Rhizoma Cimicifugae, funny face Rhizoma Cimicifugae, big cattle card holder, Radix Longan, hole root of the tooth. There is heat-clearing and toxic substances removing; Deliver rash; Effect of ascending up spleen-Qi and Yang. Spire can make cold vegetable dish in sauce, cooking or staple food dish filling equally. There is effect of removing toxic substances, sore-throat relieving, detumescence. Control gastritis, toothache, laryngopharynx swelling and pain, aphtha of the mouth and tongue etc. Semen Cassiae is leguminous plant Semen Cassiae and the mature seed of little Semen Cassiae. There are liver heat removing kidney tonifying, improving eyesight, effect of diuretic relieving constipation. Curing mainly conjunctival congestion and swelling pain, photophobia tear is many, optic atrohic blindness, nyctalopia, headache and dizzy, poor vision, cirrhotic ascites, dysuria, habitual constipation. External treatment toxic swelling, tinea. Wind heat acute conjunctivitis, hypertension, hepatitis, liver hard ascites habitual constipation etc. is effective in cure. Semen Cassiae is for diseases such as conjunctival congestion and swelling pain, the many tear of photophobia, optic atrophys. Conjunctival congestion and swelling pain, the disease such as many tears of photophobia, is disturbing upward of liver-fire, or stops up caused by the head in wind heat. Semen Cassiae can let out clearly liver and gall stagnated fire, again can dispelling wind and heat pathogens, for controlling conjunctival congestion and swelling pain key medicine. Wind heat person, is often equal to use with Periostracum Cicadae, Flos Chrysanthemi; Liver-fire person, often joins Radix Gentianae, Radix Scutellariae, the equivalent use of Spica Prunellae. Optic atrophy, how caused by deficiency of the liver and kindey. Semen Cassiae liver heat removing and improving eyesight, be often equal to use with tonic Liver and kidney medicine such as Semen Astragali Complanati, Fructus Ligustri Lucidi, Fructus Lycii, the Radix Rehmanniae, to control optic atrophy. Semen Cassiae bitter cold enters liver, can clearing away liver-fire, hold concurrently again can suppressing liver-YANG, therefore available control the headache of excessive rising of liver-YANG, dizziness, often join Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Spica Prunellae etc. medicinal. Semen Cassiae nature and flavor are sweet salty-cold, double enter large intestine channel and can clearing away heat and moistening the bowels relieving constipation, for interior-heat dryness of the intestine, constipation, use can be equal to Fructus Cannabis, Semen Trichosanthis.

In order to express the Chinese medicine composition of the present invention better, the Chinese medicine composition of the present invention can be prepared as dosage form conventional clinically. Such as, the preparation such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule. Preferably, Chinese medicine composition of the present invention conventionally preparation technology prepares into powder, water preparation, tablet or capsule.

The preparation method that present invention also offers a kind of Chinese medicine composition described above, it mainly comprises following step: takes the above-mentioned Chinese crude drug of recipe quantity and is broken into coarse powder, the alcoholic solution that volumetric concentration is 40%-95% is added according to 4-9 times of coarse powder gross weight, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method, such as tablet, capsule etc.

The present invention is also claimed above-mentioned Chinese medicine composition purposes in preparation treatment acute cholecystitis medicine. Pharmaceutical composition of the present invention is when treating acute cholecystitis, it is shown that significant anti-inflammatory and antalgic, activating blood circulation to dissipate blood stasis activity. Test examples 19 of the present invention shows, compare with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all can significantly reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear significantly inhibiting dimethylbenzene induction, and the reducing effect of ear swelling is existed significant dose-effect relationship by it. Under same experiment condition, positive control drug enteritis curing capsule group is significantly reduced ear swelling value (P < 0.05), but its antiphlogistic effects is substantially not as good as Chinese medicine composition of the present invention. Test examples 20 of the present invention shows, mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the mice of each administration group of Chinese medicine composition of the present invention add foot reaction incubation period be all higher than model group, there is dose-dependence, and be noticeably greater than model group (P < 0.05) incubation period of high dose group. Illustrate that what this Chinese medicine composition of the present invention can extend that hot plate stimulates by mice adds the sufficient response latency, have certain analgesic activity. Under same experiment condition, positive control drug Rifaximin capsule group (P < 0.05) and enteritis curing capsule group (1h, P < 0.05; 2h, P < 0.01) also significantly extend mice add foot reaction incubation period, have certain analgesic activity. Test examples 21 of the present invention shows, model group compares with normal control, and the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (P < 0.05). Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high is all notable or pole significantly reduces the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein there were significant differences (P < 0.05) for high dose. Under same experiment condition, positive control drug Rifaximin capsule group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention. The result statistics display of liver index, model group compares with normal control, and liver index significantly increases. And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduces liver index (P < 0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce liver index (P < 0.05) significantly, but effect is not as good as Chinese medicine composition of the present invention. Embodiment 22 result shows, most pathogenic entero becteria is respectively provided with good fungistatic effect by Chinese medicine composition of the present invention, this shows that the acute cholecystitis that Chinese medicine composition of the present invention causes for various bacteria or fungus is respectively provided with significant therapeutic effect, it is possible to infectious acute cholecystitis plays the effect for the treatment of both the principal and secondary aspects of a disease. And more estimable, containing plurality of active ingredients in Chinese medicine composition of the present invention, during for acute cholecystitis treatment of infection, target spot is many, is not likely to produce drug resistance, is significantly better than in existing clinic widely used antibiotics class medicine.

In a word, pharmaceutical composition of the present invention, in treatment acute cholecystitis, compared with prior art has the advantage that

1) compared with positive control drug Rifaximin capsule or enteritis curing capsule, pharmaceutical composition Chinese medicine composition of the present invention is not only more notable at antiinflammatory and ease pain, and in activating blood circulation to dissipate blood stasis, also it is significantly better than positive drug, this shows that the present composition has significant synergism in acute cholecystitis is treated, the symptom of acute cholecystitis can not only be significantly improved, the development of acute cholecystitis can also be delayed, contribute to the recovery process of acute cholecystitis patient;

2) compared with the chemotherapeutic agent of Current therapeutic acute cholecystitis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine composition effect of the present invention is comprehensive, medication effect more preferably, significantly improves the compliance of acute cholecystitis patient, and improves the quality of life of patient;

3) existing antibiotic medicine acute cholecystitis initial therapy effect still can, but along with obvious drug resistance problem all occurs in the prolongation for the treatment of time, it declines for the therapeutic effect of acute cholecystitis; Containing multi-medicament component in Chinese medicine composition of the present invention, action target spot is numerous, efficiently solves the Commpensation And Adaptation of acute cholecystitis medicine, and the therapeutic effect of acute cholecystitis is not declined by it because treatment time extends.

Detailed description of the invention

Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example. Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.

The preparation of Part I Chinese medicinal composition preparation of the present invention and using method thereof

Embodiment 1-6 Chinese medicine composition composition powders

Table 1 Chinese medicine composition composition powders prescription of the present invention

Embodiment 1 preparation method: take each medical material in compositions, conventionally technique grinds to form powdery, crosses 100 mesh sieves, and little fire drying is standby. During use, directly take after mixing it with water with after water dissolution. Embodiment 2-6 preparation method is with embodiment 1.

Embodiment 7-12 Chinese medicine composition water preparation

Table 2 Chinese medicine composition water preparation prescription of the present invention

Embodiment 7 preparation method: take each medical material, conventionally decocting for Chinese herbal medicine technological operation in prescription, filter medicinal residues and get final product. When this water preparation (or claiming decoction) is treated for acute cholecystitis, daily 2-3 time. Embodiment 8-12 preparation method and using method are with embodiment 7.

Embodiment 13-18 Chinese medicine composition tablet/capsule of the present invention

Table 3 Chinese medicine composition tablet of the present invention/capsule prescription

Embodiment 13 preparation technology: each traditional Chinese medicine powder taking recipe quantity is broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is the alcoholic solution of 80%, reflux, extract, three times, the each 3h of return time, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; By Chinese medical concrete drying, pulverize and make dried cream powder, add customary adjuvant components utilising prior art and prepare into tablet or capsule. Embodiment 14-18 preparation technology is with embodiment 13.

Part II Chinese medicine composition pharmacodynamic study of the present invention

Embodiment 19 Chinese medicine composition xylol of the present invention causes the impact of mice ear

Take healthy ICR mice 72, �� half and half, divide 6 groups, 12/group, i.e. model group, Rifaximin capsule (Hainan company limited of SANYE pharmaceutical factory, lower same), enteritis curing capsule group (Haikou Kangliyuan Pharmaceutical Co., Ltd), Chinese medicine composition of the present invention (preparing by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group. Every ig is administered 1 time/d; Administration 14d, 60min after last medicine, mouse right ear uniform application dimethylbenzene 0.03mL/ only causes swollen, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg). Swelling value=auris dextra weight-left ear weight.

Result shows, compare with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all can significantly reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear significantly inhibiting dimethylbenzene induction, and the reducing effect of ear swelling is existed significant dose-effect relationship by it. Under same experiment condition, positive control drug enteritis curing capsule group is significantly reduced ear swelling value (P < 0.05), but its antiphlogistic effects is substantially not as good as Chinese medicine composition of the present invention.

The impact of table 4 Chinese medicine composition of the present invention xylol induced mice ear swelling ()

Note: compare with model group, * P < 0.05, * * P < 0.01.

Mouse hot-plate analgesic is affected by embodiment 20 Chinese medicine composition of the present invention

1 mouse hot-plate pain model makes

About body weight 20g female mice is placed on hot plate dolorimeter, screen qualified �� mice 90 (to lick metapedes time < 5s or > 30s to throw aside, for preventing foot from scalding, also deadline should be set, it is generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, take 72 jennies, it is divided into 6 groups, 12/group, i.e. model group, Rifaximin capsule, enteritis curing capsule group, Chinese medicine composition of the present invention (prepares) low dose group by Chinese medicine composition prescription described in embodiment 1 and preparation technology, middle dosage group and high dose group. each group is gastric infusion, 1 times/day.

The Chinese medicine composition of the present invention impact on licking the foot response latency in mouse hot-plate analgesic experiment

Mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the mice of each administration group of Chinese medicine composition of the present invention add foot reaction incubation period be all higher than model group, there is dose-dependence, and be noticeably greater than model group (P < 0.05) incubation period of high dose group. Illustrate that what this Chinese medicine composition of the present invention can extend that hot plate stimulates by mice adds the sufficient response latency, have certain analgesic activity. Under same experiment condition, positive control drug Rifaximin capsule group (P < 0.05) and enteritis curing capsule group (1h, P < 0.05; 2h, P < 0.01) also significantly extend mice add foot reaction incubation period, have certain analgesic activity. Result is in Table 5.

Table 5 mice lick foot response latency timetable ()

Note: compare with model group, * P < 0.05, * * P < 0.01.

The embodiment 21 Chinese medicine composition of the present invention improvement result to rat blood stasis models

Take healthy SD rat, body weight 180-200g, 70, male and female half and half, it is randomly divided into 7 groups: Normal group, model group, Rifaximin capsule group, enteritis curing capsule group and basic, normal, high group of Chinese medicine composition of the present invention (preparing by Chinese medicine composition prescription described in embodiment 1 and preparation technology), often group 10 by body weight. Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding drug administration. 13rd day, 14 days, except Normal group, all the other treated animals pressed 1mg/kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h. It is administered the 15th day and takes 4-5ml blood anticoagulant heparin and measure blood rheology parameter, take liver and weigh conversion organ coefficient.

Dosage is table 7 such as.

Result shows, model group compares with normal control, and the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (P < 0.05). Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high is all notable or pole significantly reduces the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein there were significant differences (P < 0.05) for high dose. Under same experiment condition, positive control drug Rifaximin capsule group and enteritis curing capsule group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention. The result statistics display of liver index, model group compares with normal control, and liver index significantly increases. And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduces liver index (P < 0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce liver index (P < 0.05) significantly, but effect is not as good as Chinese medicine composition of the present invention.

Table 6 Chinese medicine composition of the present invention on the impact of rat blood stasis models lectin from hemolymph ()

Note: compare with normal control, #P < 0.05, ##P < 0.01; Compare with model group, * P < 0.05, * * P < 0.01

Table 7 Chinese medicine composition of the present invention on the impact of rat blood stasis models liver coefficient ()

Note: compare with normal control, ##P < 0.01; Compare with model group, * P < 0.05, * * P < 0.01.

The embodiment 22 Chinese medicine composition of the present invention antibacterial experiment in vitro to common enteropathic antibacterial

1, experiment material and method

Strain that this experiment uses and culture medium respectively Candida albicans, dysentery bacterium, colon bacillus, proteus vulgaris, Salmonella, shigella dysenteriae, staphylococcus aureus, resistance to methoxy staphylococcus aureus and campylobacter jejuni, clostridium perfringens enterotoxin, nutrient agar (Nat'l Pharmaceutical & Biological Products Control Institute); Opacity tube (China's bacterial turbidity standard, medicine biology combinations calibrating institute of China).

Antibacterial experiment in vitro: 1. prepare pastille agar plate; Tested material is pressed the culture medium of doubling dilution preparation different pharmaceutical concentration, heating, and modulation is required pH value each, and 121 DEG C of sterilizing 30min are cooled to 45 DEG C; Pour into into aseptic flat board (plate d=65mm, 10ml/ plate), finally make extension rate respectively l:2,1:4 containing tested material stock solution (2g/ml) in culture medium ... 1:1024; Do respective blank culture medium simultaneously; 2. inoculate; Take the bacterium in young age reaching the third generation, respectively with 0.9% sodium chloride solution by the bacterium solution to be checked that standard opacity tube corrected concentrations is 108cfu/ml, it is inoculated in the respective pastille agar surface of different doubling dilution respectively, inoculates parallel point 3 point simultaneously, make at every containing 2 one bacterium solution; The liquid-drop diameter of each vaccination is 5-8mm; Point to be seeded is dried, and upset flat board cultivates 20h observed result (simultaneously doing blank) in 36 DEG C of constant incubators; 3. criterion; With the minimum dilution tested material concentration on the agar plate occurring without bacterium colony for its minimum inhibitory concentration (MIC); In this experiment, Chinese medicine composition is as shown in table 8 to the minimal inhibitory concentration of each pathogenic strain.

, experimental result and analysis

The minimal inhibitory concentration measurement result that common pathogen is lived by table 8 arctigenin

Result shows, most pathogenic entero becteria is respectively provided with good fungistatic effect by Chinese medicine composition of the present invention, this shows that the acute cholecystitis that Chinese medicine composition of the present invention causes for various bacteria or fungus is respectively provided with significant therapeutic effect, it is possible to infectious acute cholecystitis plays the effect for the treatment of both the principal and secondary aspects of a disease. And more estimable, containing plurality of active ingredients in Chinese medicine composition of the present invention, during for acute cholecystitis treatment of infection, target spot is many, is not likely to produce drug resistance, is significantly better than in existing clinic widely used antibiotics class medicine.

The clinical data of embodiment 23 traditional Chinese medicine composition for treating acute cholecystitis of the present invention:

Case selection: select in March, 2011 in June, 2013 acute cholecystitis patient 200 example, wherein male 95 example, women 105 example; Age 15-73 year, average (34 �� 8) year; All having stomachache, heating, stomachache is positioned under right upper quadrant of the abdomen or xiphoid-process and with Nausea and vomiting person 184 example, body temperature 37.5-38.9 DEG C of person 142 example; Jaundice person 115 example, neutrophilic leukocyte rising person 168 example occur. It is divided into treatment group and each 100 examples of matched group by random digits table. The no significant differences (P > 0.05) such as two groups of Genders, age, symptoms, have comparability.

Diagnostic criteria: formulating 1. symptom with reference to " clinical disease diagnosis is according to curing improvement standard ": upper right abdomen constant pain, paroxysmal increases the weight of, and shoulder radiation to the right, companion's Nausea and vomiting and heating; 2. sign: upper right abdominal pressure pain, muscle tonus, Fei Shi does not levy the positive, sometimes can lay one's hand on and have the enlargement gallbladder of tenderness; 3. blood test: total white blood cells and neutrophil count significantly raise, part has liver function to change, serum total bilirubin slightly increases; 4. ultrasound diagnosis: gollbladder dilation, cyst wall thickens, it is seen that foreign body ripple, light blob, sound shadow.

Excluded cases standard: 1. have the important organ dysfunction persons such as severe cardiac, liver, kidney; 2. gestation or women breast-feeding their children, allergic constitution person; 3. it is associated with severe complication and is badly in need of operative treatment person, such as perforation of gallbladder, acute diffuse peritonitis or Acute necrotising pancreatitis etc.; 4. single calculus > 0.5cm person is pointed out in ultrasound diagnosis; 5. ultrasound diagnosis prompting neck of gallbladder does not substantially block person; 6. Subtotal gastrectomy art was done, especially BillrathII formula person.

Therapeutic Method: two groups of equal fasting, water (except medicine), still needs arrangement gastrointestinal decompression with serious vomiter, gives suitable fluid infusion, corrects water and rock-soil coupling, maintains acid-base balance. Matched group routine uses antibacterials, based on third-generation cephalosporin and quinolones, adds depending on the state of an illness and uses spasmolysis and analgesia medicine. Treatment group adopts the tablet of the embodiment of the present invention 1 preparation; Every day 3 times, each 3.

Observation item: observe patient and suffer from abdominal pain disappearance and abdominal distention remission time and other clinical symptoms and sign.

Curative effect judging standard: clinical cure: in 3d, symptom, sign are alleviated; In 7d, symptom, sign disappear, and lab testing indices is all normal; Effective: in 7d, symptom, sign significantly alleviate, every laboratory normally or only a little higher than normal value; Effective: in 7d, symptom, sign alleviate, every lab testing is significantly improved; Invalid: in 7d, symptom, sign have no and be obviously improved, and even worsen or turn operative treatment.

Table 9 Chinese medicine composition of the present invention is for the therapeutic effect of cholecystitis

Number of white blood cells before and after table 10 acute cholecystitis patient treatment

Claims

1. the method for the Chinese medicine composition preparing treatment acute cholecystitis, it is characterised in that comprise the technical steps that:

(1) following raw material is weighed by weight: Herba Andrographis 10 parts, Fructus Gardeniae 10 parts, 15 parts of Flos Sophorae, 5 parts of Radix Rehmanniae Preparata, Luo Xing grass 5 parts, Bulbus Lilii 5 parts, Flos Lonicerae 5 parts, Rhizoma Alismatis 5 parts, Fructus Cnidii 15 parts, Fructus Lycii 5 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 9 parts, Herba Dichodrae 5 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Zingiberis 9 parts, 12 parts of Radix Glycyrrhizae, Rhizoma Cimicifugae 5 parts, Semen Cassiae 9 parts;

(2) above-mentioned raw materials being broken into coarse powder, adding volumetric concentration according to 4��9 times of coarse powder gross weight is the alcoholic solution of 40%��95%, reflux, extract, three times, return time is 2��5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.

2. the method for the Chinese medicine composition of preparation treatment acute cholecystitis as claimed in claim 1, it is characterised in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.