CN105616210B - A kind of children sunscreen skin care rose product and preparation method thereof - Google Patents
A kind of children sunscreen skin care rose product and preparation method thereof Download PDFInfo
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- CN105616210B CN105616210B CN201610176306.1A CN201610176306A CN105616210B CN 105616210 B CN105616210 B CN 105616210B CN 201610176306 A CN201610176306 A CN 201610176306A CN 105616210 B CN105616210 B CN 105616210B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a kind of children sunscreen skin care rose product and preparation method thereof, belong to filed of daily-use chemical industry.Children sunscreen skin care rose product disclosed by the invention remove first synephrine, Rosa Damascana including the trans asafoetide acyl groups of N.The children sunscreen skin care rose product of the present invention include the trans asafoetide acyl groups of natural amides compound N and remove first synephrine and Rosa Damascana; children's skin care item are made not only to have the function that more significantly absorption ultraviolet is sun-proof; its sun-proof result chemical sunscreen single better than composition; and it is safe and reliable, it is adapted to children to use.
Description
Technical field
The present invention relates to a kind of children sunscreen skin care rose product and preparation method thereof, belong to filed of daily-use chemical industry.
Background technology
Cosmetics for children means for the age cosmetics that at 12 years old and following children used.Child skin thickness is only grown up
The 1/10 of skin, it is relatively delicate, therefore the skincare product of infant should be used no or little on skin health influentialization as far as possible
Product.On 2 1st, 2013, formulated by State Food and Drug Administration《Guide is declared and evaluated to cosmetics for children》Will
Formal to implement, opinion original text proposes particular/special requirement to the formula of cosmetics for children.Being formulated raw materials used kind must be to greatest extent
Reduce on ground.Essence, colouring agent, preservative and during surfactant are selected, few use on the basis of should adhering to effectively, without principle.
In recent years, because of the random discharge of the gases such as freon, atmospheric ozone layer is increasingly thin, and the ultraviolet for reaching ground is strong
Benefit of subsisting increase, injury of the ultraviolet to human body is also increasingly heavier, and research is found, excessive ultraviolet causes huge wound to human body
Evil, wherein 80% injury occurred in the Childhood.Therefore for sun-proof angle, protection lattice of the children sunscreen product to infant
Outer important, its research and development has very big necessity.
With the incidence of disease of harm of the ultraviolet to human body and cutaneum carcinoma the whole world present rise trend the problems such as increasingly by
Pay attention to people, sun protection Quality Research has caused the concern of countries in the world.
Common sunscreen productses are easily brought the problems such as stimulation, allergy and cumulative toxicity, therefore are directed to domestic market, are opened
To send out a kind of low to stimulate, gentle children sunscreen product have certain value.Currently used sun-screening agent includes p-aminophenyl
Formic acid derivates, anthranilate derivatives, cinnamate derivative, salicylic acid esters, Benzophenones compound, camphor derive
Thing, methane Derivatives etc., above-mentioned substance have certain excitant to skin, potential safety hazard be present.Excessive chemical UV is sun-proof
Agent may cause skin irritatin and polytype injury to skin.Therefore exploitation is potentially suitable with good sun-proof result
The safe sunlight screening skin-protecting product of suitable children has broad application prospects.
Based on problem above, the invention discloses a kind of children sunscreen skin care rose product, the children sunscreen skin care rose product
Include the trans asafoetide acyl groups of natural amides compound N- and remove first synephrine and Rosa Damascana, the trans asafoetide acyl groups of N- are gone
First synephrine has very strong UV absorption in UV-B areas, and absorption intensity is big, can effectively absorb the ultraviolet in sunlight, prevent people
It is body skin turn to red because of sun burn, sunburn, tanned, and the medicine of light sensation dermatitis, can be as the sun-prevention component of sun care preparations, rhodamine toner
Oil has good beautifying skin-protection function, supports outer Kohakuhi within energy, promotes melanin to decompose, improve dry skin, recovers
Skin elasticity, women is allowed to possess healthy skin pale, full of elasticity, thus it is sun-proof with sun-screening agent Rosa Damascana compatibility, preparation
Skin protection cosmetics, obtained cosmetics SPF is high, and compared with pure chemistry sun-screening agent, security is more preferable, it is not easy to causes
Allergic reaction, suitable children use.
The content of the invention
It is an object of the invention to provide a kind of children sunscreen skin care rose product.The children sunscreen skin care rose product include N-
Trans asafoetide acyl group removes first synephrine and Rosa Damascana.
Preferably, N- trans asafoetide acyl group of the described children sunscreen skin care rose product including 5-30 parts by weight goes first pungent not
The dispersion liquid of woods, the Rosa Damascana of 4-20 parts by weight.
Wherein, the trans asafoetide acyl groups of N- go first synephrine dispersion liquid anti-with the N- of 2 parts by weight absolute ethyl alcohols, 8 parts by weight of dissolving
After formula asafoetide acyl group removes first synephrine, add the distilled water of 20 parts by weight to mix and produce.
In addition, children sunscreen skin care rose product of the present invention can also include pharmaceutically acceptable carrier or into
Point.
Preferably, described children sunscreen skin care rose product also include the Dimethicodiethylbenzalmalonate of 2-10 parts by weight；0.2-0.8
The acrylate of parts by weight/C10-30 alkylol acrylamide acid esters cross-linked polymers；The poly- diformazan of PEG-11 methyl ethers of 0.4-1.0 parts by weight
Radical siloxane；The arginine of 0.5-1 parts by weight；The fresh milk of 3-6 parts by weight；The polyglycereol of 1-5 parts by weight；0.1-1.0 parts by weight
Acrylamide dimethyltaurine ammonium/VP copolymers.
The invention also discloses the preparation method of the children sunscreen skin care rose product, described preparation method are as follows：
(1) aqueous phase is prepared：Acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers are added to the water, and add PEG-
11 methyl ether dimethicone stirring and dissolvings；
(2) oil phase is prepared：Rosa Damascana and Dimethicodiethylbenzalmalonate stirring and dissolving；
(3) emulsify：The oil phase of step (2) is added in the aqueous phase of step (1), homogenized；
(4) acrylamide dimethyltaurine ammonium/VP copolymers thickening is added；
(5) the trans asafoetide acyl groups of N- are added and removes first synephrine dispersion liquid so that be uniformly dispersed；
(6) polyglycereol, arginine and fresh milk, stirring and dissolving are added.
Compared with the prior art the present invention, has advantages below：
The trans asafoetide acyl groups of N- go first synephrine to have very strong UV absorption in UV-B areas, and absorption intensity is big, can be effectively
The ultraviolet in sunlight is absorbed, human body skin turn to red because of sun burn, sunburn, tanned, and the medicine of light sensation dermatitis is prevented, can be used as anti-
The sun-prevention component of cosmetics is shone, with sun-screening agent Rosa Damascana compatibility, prepares sun-proof skin care cosmetics, the obtained sun-proof finger of cosmetics
Number is high, and compared with pure chemistry sun-screening agent, security is more preferable, it is not easy to causes allergic reaction.
Brief description of the drawings
Fig. 1 is the measurement result of children sunscreen skin care rose product UVResistant effect.
Embodiment
Technical scheme is described in further detail with reference to specific embodiment, but protection scope of the present invention is not
It is confined to the embodiment.
The trans asafoetide acyl groups of the N- of embodiment 1 go the preparation of first synephrine
The trans asafoetide acyl groups of N- go first synephrine synthetic method specific steps with reference to journal article：Zhengrong Wu,
Lifang Zheng,Yang Li,et al.Synthesis and structure–activity relationships and
effects of phenylpropanoid amides of octopamine and dopamine on tyrosinase
inhibition and antioxidation,Food Chemistry.134(2012)1128-1131.
Spectral data is as follows：The trans asafoetide acyl groups of N- remove first synephrine：Pale yellow powder, fusing point:183-185℃；IR
(KBr,cm-1):3361,3020-2930,1653,1594-1514,1268-1213；1H NMR(CD3OD-d4,400 MHz).δ:
3.43 (dd, J=13.6,8.0 Hz, 1H), 3.52 (dd, J=13.6,5.2 Hz, 1H), 3.88 (s, 3H), 4.72 (dd, J=
7.6,5.2 Hz, 1H), 6.46 (d, J=15.6 Hz, 1H), 6.76 (d, J=8.8 Hz, 2H), 6.78 (d, J=8.5 Hz,
1H), 7.02 (dd, J=8.4,1.2Hz, 1H), 7.12 (s, 1H), 7.23 (d, J=8.5 Hz, 2H), 7.44 (d, J=15.6
Hz,1H)；13C NMR(CD3OD-d4,100 MHz)δ:169.5,158.1,149.9,149.3,142.2,134.7,128.5,
128.3,123.3,118.7,116.5,116.1,111.6,73.4,56.4,48.3；HRMS:m/z 352.1149(calcd
for C18H19NO5+Na,352.1155)。
The preparation of the children sunscreen skin care rose product of embodiment 2
1. the formula of children sunscreen skin care rose product
Formula 1：
The 50g trans asafoetide acyl groups of N- remove the dispersion liquid of first synephrine；20g Dimethicodiethylbenzalmalonate；2g acrylate/
C10-30 alkylol acrylamide acid esters cross-linked polymers；4g PEG-11 methyl ether dimethicones；40g Rosa Damascana；5g essences
Propylhomoserin；30g fresh milks；10g polyglycereol；1g acrylamide dimethyltaurine ammonium/VP copolymers.
Formula 2：
The 170g trans asafoetide acyl groups of N- remove the dispersion liquid of first synephrine；60g Dimethicodiethylbenzalmalonate；5g acrylate/
C10-30 alkylol acrylamide acid esters cross-linked polymers；7g PEG-11 methyl ether dimethicones；120g Rosa Damascana；7g essences
Propylhomoserin；40g fresh milks；30g polyglycereol；5g acrylamide dimethyltaurine ammonium/VP copolymers.
Formula 3：
The 300g trans asafoetide acyl groups of N- remove the dispersion liquid of first synephrine；100g Dimethicodiethylbenzalmalonate；8g acrylic acid
Ester/C10-30 alkylol acrylamide acid esters cross-linked polymers；10g PEG-11 methyl ether dimethicones；200g Rosa Damascana；
10g arginine；60g fresh milk；50g polyglycereol；10g acrylamide dimethyltaurine ammonium/VP copolymers.
The trans asafoetide acyl groups of 2.N- go the preparation of first synephrine dispersion liquid
After removing first synephrine with the 20g absolute ethyl alcohols dissolving 80g trans asafoetide acyl groups of N-, distilled water 200g is added to mix i.e.
.
3. the preparation method of children sunscreen skin care rose product
(1) aqueous phase is prepared：Acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers are added to the water, and add PEG-
11 methyl ether dimethicone stirring and dissolvings.
(2) oil phase is prepared：Rosa Damascana and Dimethicodiethylbenzalmalonate stirring and dissolving.
(3) emulsify：The oil phase of step (2) is added in the aqueous phase of step (1), homogenized.
(4) acrylamide dimethyltaurine ammonium/VP copolymers thickening is added.
(5) the trans asafoetide acyl groups of N- are added and removes first synephrine dispersion liquid so that be uniformly dispersed.
(6) polyglycereol, arginine and fresh milk, stirring and dissolving are added.
The measure of the children sunscreen skin care rose product UVResistant effect of embodiment 3
1. the preparation of sample
Prepared by the preparation method of formula 1 in embodiment 2.
Formula：The 50g trans asafoetide acyl groups of N- remove the dispersion liquid of first synephrine；20g Dimethicodiethylbenzalmalonate；2g propylene
Acid esters/C10-30 alkylol acrylamide acid esters cross-linked polymers；4g PEG-11 methyl ether dimethicones；40g Rosa Damascanas；5g
Arginine；30g fresh milks；10g polyglycereol；1g acrylamide dimethyltaurine ammonium/VP copolymers.
Preparation method：
(1) aqueous phase is prepared：Acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers are added to the water, and add PEG-
11 methyl ether dimethicone stirring and dissolvings.
(2) oil phase is prepared：Rosa Damascana and Dimethicodiethylbenzalmalonate stirring and dissolving.
(3) emulsify：The oil phase of step (2) is added in the aqueous phase of step (1), homogenized.
(4) acrylamide dimethyltaurine ammonium/VP copolymers thickening is added.
(5) the trans asafoetide acyl groups of N- are added and removes first synephrine dispersion liquid so that be uniformly dispersed.
(6) polyglycereol, arginine and fresh milk, stirring and dissolving are added.
2. the preparation of control
Formula：20g Dimethicodiethylbenzalmalonate；2g acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers；4g's
PEG-11 methyl ether dimethicones；5g arginine；30g fresh milk；10g polyglycereol；1g acrylamide dimethyl
Taurine ammonium/VP copolymers.
Preparation method：
(1) aqueous phase is prepared：Acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers are added to the water, and add PEG-
11 methyl ether dimethicone stirring and dissolvings.
(2) oil phase：For Dimethicodiethylbenzalmalonate.
(3) emulsify：The oil phase of step (2) is added in the aqueous phase of step (1), homogenized.
(4) acrylamide dimethyltaurine ammonium/VP copolymers thickening is added.
(5) polyglycereol, arginine and fresh milk, stirring and dissolving are added.
3. the measure of children sunscreen skin care rose product UVResistant effect
The present embodiment determines the sun-proof result of manufactured sun care preparations using 3M adhesive tapes method.
3M medical air-permeable adhesive tapes are cut into 1cm × 4cm sizes, are pasted onto quartz colorimetric utensil printing opacity side surface.It is accurate to claim
Test sample 35mg, test sample is applied on quartz colorimetric utensil, is placed in 35 DEG C of drying boxes, is dried 30 minutes.Then with ultraviolet
Spectrophotometer is 285nm, 290nm, 295nm in Detection wavelength, 300nm, 305nm, 310nm, 315nm, 320nm detections, often
Individual test sample setting five is parallel, determines OD values, OD values are bigger, better to UVB protection effect.
It can be seen from Fig. 1 results under same concentration, the OD values of children sunscreen skin care rose product disclosed by the invention
First synephrine group is gone apparently higher than control group, Rosa Damascana group and the trans asafoetide acyl groups of N-, shows to contain the trans asafoetides of N- simultaneously
Acyl group goes children sunscreen skin care rose product prescription uvioresistant effect/anti-sunlight function of first synephrine and Rosa Damascana to be significantly higher than
The effect of first synephrine experimental group, Rosa Damascana are individually removed containing the trans asafoetide acyl groups of N- containing Rosa Damascana experimental group and individually
Go between first synephrine that there is Synergistic with the trans asafoetide acyl groups of N-.
Claims (6)
- A kind of 1. children sunscreen skin care rose product, it is characterised in that described children sunscreen skin care rose product include N- trans Ah Wei's acyl group removes first synephrine and Rosa Damascana.
- 2. children sunscreen skin care rose product according to claim 1, it is characterised in that described children sunscreen skin care rose Product remove first synephrine dispersion liquid and the Rosa Damascana of 4-20 parts by weight including the trans asafoetide acyl groups of 5-30 parts by weight N-.
- 3. children sunscreen skin care rose product according to claim 2, it is characterised in that the trans asafoetide acyl groups of described N- are gone First synephrine dispersion liquid is prepared by the following method：The trans asafoetide acyl groups of N- that 8 parts by weight are dissolved with 2 parts by weight absolute ethyl alcohols go first After synephrine, add the distilled water of 20 parts by weight to mix and produce.
- 4. children sunscreen skin care rose product according to claim 1 or 2, it is characterised in that described children sunscreen rose Skin care item also include pharmaceutically acceptable carrier or composition.
- 5. children sunscreen skin care rose product according to claim 4, it is characterised in that described pharmaceutically acceptable load Body or composition are：The Dimethicodiethylbenzalmalonate of 2-10 parts by weight；The acrylate of 0.2-0.8 parts by weight/C10-30 alkylol acrylamide acid esters Cross-linked polymer；The PEG-11 methyl ether dimethicones of 0.4-1.0 parts by weight；The arginine of 0.5-1 parts by weight；3-6 weights Measure the fresh milk of part；The polyglycereol of 1-5 parts by weight；Acrylamide dimethyltaurine ammonium/VP copolymers of 0.1-1.0 parts by weight.
- 6. children sunscreen skin care rose product according to claim 5, it is characterised in that the children sunscreen skin care rose product Preparation method it is as follows：(1) aqueous phase is prepared：Acrylate/C10-30 alkylol acrylamide acid esters cross-linked polymers are added to the water, and add PEG-11 first Ether dimethyl silicone polymer stirring and dissolving；(2) oil phase is prepared：Rosa Damascana and Dimethicodiethylbenzalmalonate stirring and dissolving；(3) emulsify：The oil phase of step (2) is added in the aqueous phase of step (1), homogenized；(4) acrylamide dimethyltaurine ammonium/VP copolymers thickening is added；(5) the trans asafoetide acyl groups of N- are added and remove first synephrine dispersion liquid, stirring makes to be uniformly dispersed；(6) polyglycereol, arginine and fresh milk, stirring and dissolving are added and produces children sunscreen skin care rose product.
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| CN108014034B (en) * | 2018-01-11 | 2020-11-20 | 广东博然堂生物科技有限公司 | Sunscreen skin care product with natural plant extract as active ingredient and preparation method thereof |
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| US7632972B2 (en) * | 2003-10-30 | 2009-12-15 | The Board Of Trustees Of The University Of Illionis | Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells |
| CN102059145B (en) * | 2010-09-16 | 2012-07-11 | 中国科学技术大学 | Catalyst, method for synthesizing (S)-octopamine and method for synthesizing (S)-N-trans-feruloyloctopamine |
| CN102764228A (en) * | 2012-08-10 | 2012-11-07 | 广州理和健康产品科技有限公司 | Skin care composition |
| CN104055716B (en) * | 2014-07-11 | 2016-10-26 | 罗友群 | Vitamin repairs elite |
| CN104306196B (en) * | 2014-09-24 | 2017-01-11 | 中华人民共和国惠州出入境检验检疫局 | Multi-effect whitening and skin tendering compound essential oil and preparation method thereof |
| CN104490713A (en) * | 2015-01-06 | 2015-04-08 | 上海东晟源日化有限公司 | Super-soft living spring skin care product with functions of removing foul, tightening, resisting wrinkles and activating skin |
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