CN1056065C - Liquid medicine for chilblain and preparing process - Google Patents
Liquid medicine for chilblain and preparing process Download PDFInfo
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- CN1056065C CN1056065C CN93120364A CN93120364A CN1056065C CN 1056065 C CN1056065 C CN 1056065C CN 93120364 A CN93120364 A CN 93120364A CN 93120364 A CN93120364 A CN 93120364A CN 1056065 C CN1056065 C CN 1056065C
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- perniosis
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Abstract
The present invention relates to a drug which is prepared by natural plant extract and is used for treating chilblain and the preparation technique of the drug. Medicinal effective components of the chilblain spiritual water of the present invention contain the alcohol extract of 10 to 80g of tianqi, 10 to 60g of chonglou, 2 to 30g of angelica dahurica, 5 to 30g of wild aconite, 2 to 25g of herba asari, 1 to 15g of liquorice, 2 to 15g of cangerzi, 1 to 18g of safflower and 5 to 40g of jintiesuo. The alcohol extract is matched with 2 to 20 % of medicinal auxiliary agent to prepare an acceptable preparation in the aspect of medicine. The chilblain spiritual water is mainly used for treating and preventing the chilblain and partial frostbite, is an external drug and has the action of stopping itch, detumescence, removing pain, activating blood, dissolving stasis and warming and dredging channels.
Description
The present invention relates to a kind of medicine of the treatment chilblain that makes by natural botanical extraction liquid and the preparation technology of this medicine.
Chinese patent application CN1066591A (application number 91107041) discloses " a kind of manufacture method of chilblain medicine ", it is that primary raw material is made chilblain liquid or powder or medicine film or paper etc. that system adopts skinworm, apply on the chilblain of ulceration, other skins skin ulcer of bursting is also had certain curative effect.
Chinese patent application CN1069868A (application number 92109435) discloses a kind of " medicine health product manufacture method of anti-frostbite and products thereof ", be to get the single jersey finished product, immerse a kind of chilly ethanol extract, camphor alcohol solution, in vitamin E alcoholic solution and the Mel solution medicinal liquid that mix homogeneously is formed by a certain percentage, the sealing dipping, and turn, take out then and dry, place drying room or drying baker inner drying again, make medicinal liquid evenly be adsorbed on single jersey finished product glove with said method, socks, on the ear muff, and together with common moisture retentive glove, socks, ear muffs etc. one work, also can be used as liner, can be incubated, cold removing, anti-frostbite.
Chinese patent application CN1067817A (application number 92103546.2) discloses a kind of " chilblain spirit ointment, cream and preparation technology thereof ", by Rhizoma Paridis, Radix Notoginseng, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis etc. is principal agent, through pulverizing mixing, add in excipient vaseline, glycerol, the lanoline etc., grinding evenly makes.
It is the treatment of perniosis medicine and the preparation technology of effective medicinal components with the natural botanical extraction liquid that purpose of the present invention aims to provide a kind of.
The effective medicinal components of treatment of perniosis preparation of the present invention is: the alcohol extract of Radix Notoginseng 10-80g, Rhizoma Paridis 10-60g, Radix Angelicae Dahuricae 2-30g, Radix Aconiti Kusnezoffii 5-30g, Herba Asari 2-25g, Radix Glycyrrhizae 1-15g, Fructus Xanthii 2-15g, Flos Carthami 1-18g, Radix Psammosilenes 5-40g, be equipped with the medicinal auxiliary agent of 2-20%, make pharmaceutically acceptable dosage form.
Radix Notoginseng is the dry root of Araliaceae Radix Notoginseng Panax notogingeng (Burk) F.H.Chen in the effective medicinal components of the present invention.Record in 1990 version (an one) 7 pages of Chinese Pharmacopoeia.Rhizoma Paridis is the dry root of liliaceous plant Rhizoma Paridis Paris polyphylla Smith var.yunnanensis (Franch) Hand-Mazz or Rhizoma Paridis Parispolyphylla Smith var chinensis (Franch.) Hara, records in 1990 version (an one) 231 pages of Chinese Pharmacopoeia.Radix Psammosilenes is the dry root of pinkwort Radix Psammosilenes Psammosilenetunicoides W.C.Wuet C.Y.Wu.Record in (1974) 195 pages of Yunnan Province's pharmaceutical standards.Radix Aconiti Kusnezoffii is the tuber of ranunculaceae plant Radix Aconiti Kusnezoffii Aconitum vilmorinianu Komarou or South Yunnan Radix Aconiti Kusnezoffii Aconitum austroyunnanense W.T.Wang.Record in (1974) 210 pages of Yunnan Province's pharmaceutical standards.Herba Asari is the dry herb of aristolochiaceae plant Herba Asari Asarum heterotropides Fr.var.mandshuricum (Maxim) Kitag Seoul Herba Asari Asarum sieboldii Miq.var.seoulense Narai or magnificent Herba Asari Asarum sieboldii Miq..Record in 1990 version (an one) 198 pages of Chinese Pharmacopoeia.Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorus L.Record in 1990 version (an one) 126 pages of Chinese Pharmacopoeia.The Radix Angelicae Dahuricae is the dry root of samphire Angeli dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm) B.enth.et Hook.f.var, formosana (Boiss) shan etYuan, records in 1990 version (an one) 86 pages of Chinese Pharmacopoeia.Fructus Xanthii is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Record in 1990 version (an one) 135 pages of Chinese Pharmacopoeia.Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensisFisch Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrihiza glabra L..Record in 1990 version (an one) 71 pages of Chinese Pharmacopoeia.
The hemostasis of Radix Notoginseng dissipating blood stasis, subduing swelling and relieving pain in the prescription of the present invention; Flos Carthami is invigorated blood circulation, and stimulates the menstrual flow; Rhizoma Paridis detumescence, antiinflammatory; Being aided with Radix Aconiti Kusnezoffii, Herba Asari, Radix Psammosilenes further strengthens warming the meridian, pain relieving, sensible merit; The Radix Angelicae Dahuricae has the dense effect of detumescence row, can control the severe chilblain; Fructus Xanthii also has good rheumatism pruritus effect except that soft skin function, coordinate all medicines with Radix Glycyrrhizae at last, and with the antiinflammatory antianaphylaxis function, eliminates the allergy of only a few people to Chinese herbal medicine.Because chilblain makes cuticle thickening, add medicinal auxiliary agent and make the easier infiltration skin of medicine, bring into play its usefulness, add propylene glycol, glycerol skin care simultaneously, Hydrolyzed Protein effect again makes that medicine is unlikely to dry up because of solvent evaporates.
The preparation technology of treatment of perniosis preparation of the present invention is made up of following steps:
(1), get Radix Notoginseng, Rhizoma Paridis, the Radix Angelicae Dahuricae, Radix Aconiti Kusnezoffii, Herba Asari, Radix Glycyrrhizae, Fructus Xanthii, Flos Carthami, Radix Psammosilenes and be ground into coarse powder, add the 75-95% ethanol of 2 to 4 times of medicine coarse powder weight, at 30-72 ℃ of following lixiviate 1-6 hour, filter, lixiviating solution and medicinal residues;
(2), with the 50-75% ethanol of 2 to 4 times of medicinal residues weight to step () gained medicinal residues at 30-72 ℃ of following lixiviate 1-6 hour, filter, lixiviating solution and medicinal residues;
(3), step (two) gained medicinal residues abandon it after the drip washing of ethanol liquid, leacheate and step (one), (two) lixiviating solution merge, and obtain effective medicinal components;
(4), in effective medicinal components, add the medicinal auxiliary agent of 2-20%, make pharmaceutically acceptable dosage form, packing.
The described medicinal auxiliary agent of step (four) is that lower polyol and skin infilter agent, and its ratio is lower polyol 90-95%, and skin penetrant 5-10%, lower polyol are propylene glycol, glycerol, and skin penetrant is a Laurel ammonia cover ketone.
Liquid medicine for chilblain of the present invention can be multiple dosage form, adds the medicinal auxiliary agent of 2-10% in effective medicinal components, through perfuming, freezing, filter, can be made into tincture or aerosol; Effective medicinal components is concentrated, make medicine extractum, the medicinal auxiliary agent of adding 6-20% and greasing base, emulsion-type substrate, water-soluble base in medicine extractum, and after perfuming is handled, make the cream cream; The medicinal auxiliary agent that adds 3-10% in the medicine extractum that effective medicinal components is condensed into is through adding water, perfuming processing, making water preparation; Add the medicinal auxiliary agent of 3-9% in the medicine extractum that effective medicinal components is condensed into, add film former, perfuming is made membrane.
Liquid medicine for chilblain of the present invention is mainly used in treatment, anti-frostbite and part frozen, is topical drug, have antipruritic, subside a swelling, unsting, the effect of blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian, be 99.4% through 984 routine clinical verification effective percentage over 5 years.
Embodiment:
Get Radix Notoginseng 25g, Rhizoma Paridis 50g, Radix Angelicae Dahuricae 15g, Radix Aconiti Kusnezoffii 20g, Herba Asari 15g, Radix Glycyrrhizae 10g, Fructus Xanthii 10g, Flos Carthami 5g, Radix Psammosilenes 30g, add 3 times of weight 95% ethanol, in 50 ℃ of following lixiviates 3 hours, filter, medicinal residues filter with the lixiviate 4 hours under said temperature of 75% ethanol, and medicinal residues are with 50% ethanol drip washing, medicinal residues are abandoned it, and merging above-mentioned lixiviating solution, to make effective medicinal components stand-by.
Get propylene glycol 41%, glycerol 51%, Laurel ammonia cover ketone 8% and make medicinal auxiliary agent, stand-by.
In the 100g effective medicinal components, add the medicinal rib agent of 6g, through perfuming, freezing, filter after, make tincture or aerosol.
The 100g effective medicinal components through vacuum concentration, is made medicine extractum, add the medicinal auxiliary agent of 7g, add water 90g, perfuming is made water preparation.
In the medicine extractum that 100g makes with effective ingredient, add the medicinal auxiliary agent of 15g, the 18g silicone, 8g monoglyceride, 6g Polyethylene Glycol are made the cream cream behind perfuming.
Add the medicinal auxiliary agent of 5g in the medicine extractum that the 100g effective medicinal components is made, the 8g polyvinyl formal-acetal behind perfuming, is made membrane.
Claims (8)
1, a kind of treatment of perniosis preparation, it is characterized in that its medicinal active ingredient is: the ethanol extract of Radix Notoginseng 10-80g, Rhizoma Paridis 10-60g, Radix Angelicae Dahuricae 2-30g, Radix Aconiti Kusnezoffii 5-30g, Herba Asari 2-25g, Radix Glycyrrhizae 1-15g, Fructus Xanthii 2-15g, Flos Carthami 1-18g, Radix Psammosilenes 5-40g, used concentration of ethanol is 50-95%, be equipped with the medicinal auxiliary agent of 2-20%, make pharmaceutically acceptable dosage form.
2,, it is characterized in that forming by following steps according to the preparation technology of the described treatment of perniosis preparation of claim 1:
(1), get Radix Notoginseng, Rhizoma Paridis, the Radix Angelicae Dahuricae, Radix Aconiti Kusnezoffii, Herba Asari, Radix Glycyrrhizae, Fructus Xanthii, Flos Carthami, Radix Psammosilenes and be ground into coarse powder, add the 75-95% ethanol of 2 to 4 times of medicine coarse powder weight, at 30-72 ℃ of following lixiviate 1-6 hour, filter, lixiviating solution and medicinal residues;
(2), with the 50-75% ethanol of 2 to 4 times of medicinal residues weight to step () gained medicinal residues at 30-72 ℃ of following lixiviate 1-6 hour, filter, lixiviating solution and medicinal residues;
(3), step (two) gained medicinal residues abandon it after the drip washing of ethanol liquid, leacheate and step (one), (two) lixiviating solution merge, and obtain effective medicinal components;
(4), in effective medicinal components, add the medicinal auxiliary agent of 2-20%, make pharmaceutically acceptable dosage form, packing.
3,, it is characterized in that described medicinal auxiliary agent is lower polyol 90-95%, skin penetrant 5-10% according to the preparation technology of the described treatment of perniosis preparation of claim 1.
4,, it is characterized in that lower polyol is propylene glycol, glycerol according to the preparation technology of the described treatment of perniosis preparation of claim 3.
5, according to the preparation technology of the described treatment of perniosis preparation of claim 1, it is characterized in that in effective medicinal components adding the medicinal auxiliary agent of 2-10%, through add kind, freezing, filter, make tincture or aerosol.
6, according to the preparation technology of the described treatment of perniosis preparation of claim 1, it is characterized in that effective medicinal components is concentrated, make medicine extractum, the medicinal auxiliary agent of adding 6-20% and greasing base, emulsion-type substrate, water-soluble base in medicine extractum, and after perfuming is handled, make the cream cream.
7,, it is characterized in that in the medicine extractum that effective medicinal components is condensed into, adding the medicinal auxiliary agent of 3-10%, through adding water, perfuming processing, making water preparation according to the preparation technology of the described treatment of perniosis preparation of claim 1.
8, according to the preparation technology of the described treatment of perniosis preparation of claim 1, it is characterized in that in the medicine extractum that effective medicinal components is condensed into, adding the medicinal auxiliary agent of 3-9%, add film former, perfuming is made membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93120364A CN1056065C (en) | 1993-11-23 | 1993-11-23 | Liquid medicine for chilblain and preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93120364A CN1056065C (en) | 1993-11-23 | 1993-11-23 | Liquid medicine for chilblain and preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1102992A CN1102992A (en) | 1995-05-31 |
| CN1056065C true CN1056065C (en) | 2000-09-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93120364A Expired - Fee Related CN1056065C (en) | 1993-11-23 | 1993-11-23 | Liquid medicine for chilblain and preparing process |
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| Country | Link |
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| CN (1) | CN1056065C (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067817A (en) * | 1992-05-09 | 1993-01-13 | 朱乃军 | Chilblain spirit ointment, cream and preparation technology thereof |
-
1993
- 1993-11-23 CN CN93120364A patent/CN1056065C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067817A (en) * | 1992-05-09 | 1993-01-13 | 朱乃军 | Chilblain spirit ointment, cream and preparation technology thereof |
Non-Patent Citations (5)
| Title |
|---|
| 中国医院药学杂志1988,8(2) 1988.2.29 凌方"新冻疮膏的制备及疗效观察" * |
| 中成药1990,12(11) 1990.11.30 严忠"冻疮外治方";中成药研究1983,(12) 1983.12.31 冯亚英，陈凤阁，"冻疮药水的配制方法与使用";中国医院药学杂志1988,8(2) 1988.2.29 凌方"新冻疮膏的制备及疗效观察";中药通报1986,11(2) 1986.12.31 王丽娟，张京"介绍一种冻疮洗剂" * |
| 中成药1990,12(11) 1990.11.30 严忠"冻疮外治方" * |
| 中成药研究1983,(12) 1983.12.31 冯亚英，陈凤阁，"冻疮药水的配制方法与使用" * |
| 中药通报1986,11(2) 1986.12.31 王丽娟，张京"介绍一种冻疮洗剂" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1102992A (en) | 1995-05-31 |
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