CN105596704A - Medicine for treating diabetic angiopathy - Google Patents

Abstract

The invention discloses a medicine for treating diabetic angiopathy. The medicine comprises an orally taken medicine and an externally applied medicine; the orally taken medicine comprises Radix Ginseng, Bulbus Lilii, Rhizoma disporopsis pernyi, Ganoderma Lucidum Karst, Thallus Porphyrae, Radix Codonopsis lanceolatae, Herba Urariae crinitae, Radix Oenotherae erythrosepalae oil, Radix Tiliae, Plantula Brassicae chinensis, Folium Ilicis Cornutae and Radix Glycyrrhizae; and the externally applied medicine comprises Radix Angelicae Sinensis, Radix Ginseng, Ganoderma Lucidum Karst, Fructus syzygii cumini, Fructus Lycii and Radix Glycyrrhizae. The medicine has the beneficial effect that the medicine comprises the orally taken medicine and the externally applied medicine, the orally taken medicine and the externally applied medicine are used jointly and interwork, the medicine takes effect quickly and is good in effect when used for clinically treating diabetic retinopathy caused by deficiency of both Qi and Yin, eye pressure can be relieved effectively, retinal neovascularization is reduced effectively, vision of a patient is improved, living quality of the patient is improved, meanwhile, the medicine is high in safety and does not have toxic or side effects, and the disease is difficult to recur.

Description

Be used for the treatment of the medicine of diabetic angiopathy

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of medicine that is used for the treatment of diabetic angiopathy.

Background technology

The vascular lesion of diabetes is one of common diabetic complications, and this is also to cause one of diabetic main causes of death, and modal vascular lesion has the microangiopathies of cardiovascular pathological changes, cerebrovascular disease, kidney, retina and skin etc. BDR (DR) is most important performance in diabetic microangiopathies, is a kind of eyeground pathological changes that specificity changes that has, and is one of Complicated with Severe card of diabetes. Clinically according to whether occurring that retinal neovascularization is mark, the BDR that does not have retinal neovascularization to form is called to nonproliferative diabetic retinopathy (NPDR) (or claiming simple form or background type), becomes (PDR) and the BDR that has retinal neovascularization to form is called to proliferating diabetic retinopathy.

Develop into according to BDR (DR) basic pathogenesis: deficiency of both qi and yin, caused by liver and kidney deficiency, yin-yang deficiency transformation characteristics and the stasis of blood, strongly fragrant, three important paathogenic factors of phlegm, its traditional Chinese medical science clinical stages can be divided into early, middle and late three phases substantially. 1. early stage deficiency of both qi and yin: eyesight slightly goes down or normally, dryness with foreign body sensation in the eyes, or a little black flower is waved in the wind at the moment, and eyeground is seen a little microaneurysm of retina, is dispersed in hemorrhage and oozes out, and PVR mostly is 1～3 grade; Can accompany spiritlessness and weakness, the lazy speech of breathing hard, dry mouth and throat, spontaneous perspiration, just dry or rare half congealed, tongue is fat tender, purple dark or have an ecchymosis, deep,thready and forceless pulse. 2. mid-term caused by liver and kidney deficiency: blurred vision or distortion, dryness with foreign body sensation in the eyes, eyeground see retina extensively hemorrhage, ooze out and velveteen spot, or see vein beading and IRMA, or companion's macular edema, PVR mostly is 3～4 grades; Can accompany dizziness and tinnitus, soreness and weakness of waist and knees, extremity numbness, dry and hard excrement, the dark red few tongue of tongue, thready and hesitant pulse. 3. late period yin-yang deficiency blurred vision or lose, or sudden blind, new vessels, machine kitchen range, propagation band and tractional detachment of retina are seen in eyeground, or vitreous hemorrhage causes that eyeground cannot be peeped and, PVR mostly is 4～5 grades; Can accompany spiritlessness and weakness, dysphoria in chestpalms-soles, insomnia forgetfulness, soreness of waist limb is cold, the cool fiber crops of brothers, impotence and premature ejaculation, edema of lower extremity, large loose stool is made friends with and is replaced, light fat few Tianjin of tongue or have petechia, or words are purple dark, deep,thready and forceless pulse.

BDR is one of diabetic vascular complications, extremely important at concurrent early stage begin treatment, at present still methods for the treatment of and the medicine of effective treatment Qi and Yin deficiency diabetes mellitus PVR symptom of doctor trained in Western medicine.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine that is used for the treatment of diabetic angiopathy is provided, be used in particular for treating the medicine of Qi and Yin deficiency diabetes mellitus PVR, this medicine comprises endo-medicine and external used medicine, the two uses jointly, interact, treatment Qi and Yin deficiency diabetes mellitus PVR has instant effect, effective advantage, can effectively alleviate eye pressure, retinal neovascularization effectively disappears, improve patient's vision, improve patients ' life quality, also have safe simultaneously, have no side effect and be difficult for the advantage recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine that is used for the treatment of diabetic angiopathy, be absorbed in especially the medicine for the treatment of Qi and Yin deficiency diabetes mellitus PVR, wherein, comprise endo-medicine and external used medicine, described endo-medicine comprises: ginseng, lily, perny false fairybells rhizome, glossy ganoderma, laver, lance asiabell root, brave tail wheel, evening primrose oil, tuan linden root, Chinese cabbage, holly leaf and Radix Glycyrrhizae; Described external used medicine comprises: Radix Angelicae Sinensis, ginseng, glossy ganoderma, sheep dung fruit, the fruit of Chinese wolfberry and Radix Glycyrrhizae.

Wherein, described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, brave tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion and Radix Glycyrrhizae 7-14 weight portion.

Described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 10-15 weight portion, ginseng 7-12 weight portion, glossy ganoderma 15-25 weight portion, sheep dung fruit 15-19 weight portion, fruit of Chinese wolfberry 8-15 weight portion and Radix Glycyrrhizae 5-10 weight portion.

Described endo-medicine is preferably also made up of the raw medicinal material of following weight amount umber: ginseng 15-17 weight portion, lily 13-17 weight portion, perny false fairybells rhizome 11-14 weight portion, glossy ganoderma 18-26 weight portion, laver 17-21 weight portion, lance asiabell root 14-16 weight portion, brave tail wheel 12-14 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-3 weight portion, Chinese cabbage 13-15 weight portion, holly leaf 12-14 weight portion and Radix Glycyrrhizae 9-12 weight portion.

Described external used medicine preferably can also be made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 12-15 weight portion, ginseng 9-11 weight portion, glossy ganoderma 19-23 weight portion, sheep dung fruit 16-17 weight portion, fruit of Chinese wolfberry 10-13 weight portion and Radix Glycyrrhizae 5-7 weight portion.

Described endo-medicine preferably can be made up of the raw medicinal material of following weight amount umber again: ginseng 16 weight portions, lily 15 weight portions, perny false fairybells rhizome 12 weight portions, glossy ganoderma 23 weight portions, laver 19 weight portions, lance asiabell root 15 weight portions, brave tail wheel 13 weight portions, evening primrose oil 3 weight portions, tuan linden root 2 weight portions, Chinese cabbage 14 weight portions, holly leaf 13 weight portions and Radix Glycyrrhizae 11 weight portions.

Described external used medicine preferably can be made up of the raw medicinal material of following parts by weight again: Radix Angelicae Sinensis 13 weight portions, ginseng 10 weight portions, glossy ganoderma 21 weight portions, sheep dung fruit 16 weight portions, the fruit of Chinese wolfberry 11 weight portions and Radix Glycyrrhizae 6 weight portions.

Preferably, described endo-medicine also comprises wilsonii, sweet potato, Chinese Ladiestresses Root or Herb, dog ant grass and sheep dung fruit, described endo-medicine is made up of the raw medicinal material of following parts by weight: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, tiger tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion, Radix Glycyrrhizae 7-14 weight portion, wilsonii 12-18 weight portion, sweet potato 5-12 weight portion, Chinese Ladiestresses Root or Herb 10-17 weight portion, dog ant grass 11-17 weight portion and sheep dung fruit 7-12 weight portion.

Described endo-medicine preferably can be made up of the raw medicinal material of following weight amount umber again: ginseng 16 weight portions, lily 15 weight portions, perny false fairybells rhizome 12 weight portions, glossy ganoderma 23 weight portions, laver 19 weight portions, lance asiabell root 15 weight portions, tiger tail wheel 13 weight portions, evening primrose oil 3 weight portions, tuan linden root 2 weight portions, Chinese cabbage 14 weight portions, holly leaf 13 weight portions, Radix Glycyrrhizae 11 weight portions, wilsonii 15 weight portions, sweet potato 8 weight portions, Chinese Ladiestresses Root or Herb 13 weight portions, dog ant grass 14 weight portions and sheep dung fruit 9 weight portions.

The formulation of endo-medicine can be capsule, tablet, pill, decoction etc.; The formulation of liniment can be drops, patch, paste, the agent of subsides navel etc.

The present invention also provides a kind of endo-medicine that is used for the treatment of diabetic angiopathy, and described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, brave tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion and Radix Glycyrrhizae 7-14 weight portion; The formulation of endo-medicine can be capsule, tablet, pill, decoction etc.

The present invention provides again the external used medicine that is used for the treatment of diabetic angiopathy, and described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 10-15 weight portion, ginseng 7-12 weight portion, glossy ganoderma 15-25 weight portion, sheep dung fruit 15-19 weight portion, fruit of Chinese wolfberry 8-15 weight portion and Radix Glycyrrhizae 5-10 weight portion; The formulation of external used medicine can be drops, patch, paste, the agent of subsides navel etc.

In order better to realize foregoing invention object, the invention provides a kind of preparation method of described endo-medicine, formulation is capsule, its preparation method is specially:

The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, adds hot reflux 1～3 hour, extracts, and filters and obtains the first extract; The ethanol that it is 85～95% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1～2 times of described dregs of a decoction quality again, adds hot reflux 1～3 hour, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, successively adds talcum powder, dolomol in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, dolomol and talcous weight ratio are 100: 0.15～0.5:0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.

Formulation is tablet, and its preparation method is specially:

The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, adds hot reflux 1～3 hour, extracts, and filters and obtains the first extract; The ethanol that it is 85～95% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1～2 times of described dregs of a decoction quality again, adds hot reflux 1～3 hour, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline cellulose of 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix, granulate, dry, add with respect to 0.005～0.05 times of dolomol of micropowders quality whole grain, compressing tablet, makes.

The present invention also provides a kind of preparation method of described external used medicine, and formulation is for pasting navel agent, and its preparation method is specially:

The first step, mixes described each raw medicinal material in proportion, is ground into 40 order～60 object powder, and the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, adds hot reflux 1～3 hour, extracts, and filters and obtains the first extract; The ethanol that it is 85～95% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1～2 times of described dregs of a decoction quality again, adds hot reflux 1～3 hour, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 100 order～200 object powder;

Second step, dissolves stearic acid heating, and remaining on temperature is 70 DEG C～80 DEG C, obtains stearic acid liquid; In addition, the part by weight of potassium hydroxide, glycerine, ethylparaben and distilled water being pressed to 5:500:1:600 mixes, and heating, maintains the temperature at 70 DEG C～80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor according to the part by weight of 1:100, stir simultaneously cooling, obtain matrix;

The 3rd step, the powder that adds the first step of equivalent to obtain to the matrix of second step acquisition, and be constantly ground to evenly, heating obtains sticky paste, granulates, and after being dried, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to navel place.

Formulation is water liquid or eye drops, and its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into micronizer and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains ethanolic solution, ethanolic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly diacolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into micronizer at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 1～3g that second step obtains, and adds sodium chloride 90～110g, adds 1000ml water for injection, stirs and makes its dissolving; Inject water to 800ml; With 0.22～0.24 μ m filtering with microporous membrane; Packing embedding, sterilizing.

The invention has the beneficial effects as follows: medicine of the present invention comprises endo-medicine and external used medicine, the two uses jointly, interact, there is instant effect, effective advantage through clinical treatment Qi and Yin deficiency diabetes mellitus PVR, can effectively alleviate eye pressure, the retinal neovascularization that effectively disappears, improves patient's vision, improve patients ' life quality, also have simultaneously safe, have no side effect and be difficult for recurrence advantage.

Detailed description of the invention

BDR (DR) belongs to the traditional Chinese medical science " the order disease of quenching one's thirst ". Because the epoch are limit, in traditional Chinese medical science ancient books, do not occur that the disease that calls for specialized treatment of clear and definite relevant DR is described. But Traditional Chinese Medicine has realized that quench one's thirst (i.e. " diabetes "), final clinical symptoms can cause limbs disability, binocular blinding. In " three disappear opinion ", point out: in " the husband person of quenching one's thirst, changeable Sound is blind " " secretly hand down card control want piece " book, also clearly record: " three disappear for a long time it, and refreshing blood both lost, or order is without finding, or brothers attach undue importance to one thing to the neglect of the other ". Because diabetes spp is in the traditional Chinese medical science category of " quenching one's thirst ", for its name of disease of specification, modern Chinese medicine ophthalmology scholar is clearly " the order disease of quenching one's thirst " by DR names of disease of tcm in recent years, though embodied to a certain extent DR characteristics of incidence, but from the degree of correspondence of doctor trained in Western medicine name of disease, " the order disease of quenching one's thirst " when corresponding to doctor trained in Western medicine " diabetic oculopathy ", its intension should comprise BDR, diabetic cataract, diabetic optic neuropathy, diabetic keratopathy etc. Traditional Chinese medicine eye scientific cirle refers in particular to BDR with " the order disease of quenching one's thirst " at present. Deficiency of both qi and yin is through the overall process of diabetes. Due to deficiency of both qi and yin, in the fire of deficiency type, burn, the eyeground blood network of burning, the hyperamization network stasis of blood is stagnant, and chronic progressive external infringement is caused in eyeground, forms gradually knob (microaneurysm); Also can be mingled with some similar cured sample tone and the more clearly exudates in border, this is the thing that phlegm is turbid; In addition, heat burn blood network also can make blood overflow in outside, form little blutpunkte, number not etc., and does not occur with the fluctuating of the state of an illness repeatedly. Due to the course of disease with the passing of time, stagnation of QI-blood is constantly deepened, and can make the state of an illness further worsen, as larger vein can be changed into plucked, when serious as sausage shape; More seriously the appearance of new vessels, because new vessels is very fragile, can cause massive haemorrhage, is not easy after hemorrhage to absorb, even if partially absorb, but the stupid stasis of blood is residual, and if net is as knitted, formation is blocked, and has a strong impact on eyesight.

Present invention focuses on to provide a kind of particularly medicine of Qi and Yin deficiency diabetes mellitus PVR of diabetic angiopathy for the treatment of, comprise endo-medicine and external used medicine, endo-medicine comprises: ginseng, lily, perny false fairybells rhizome, glossy ganoderma, laver, lance asiabell root, brave tail wheel, evening primrose oil, tuan linden root, Chinese cabbage, holly leaf and Radix Glycyrrhizae, preferably also comprise wilsonii, sweet potato, Chinese Ladiestresses Root or Herb, dog ant grass and sheep dung fruit; External used medicine comprises: Radix Angelicae Sinensis, ginseng, glossy ganoderma, sheep dung fruit, the fruit of Chinese wolfberry and Radix Glycyrrhizae.

Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows:

Ginseng: sweet, micro-hardship, flat. Return spleen, lung, the heart channel of Hang-Shaoyin. Function cures mainly: reinforce vital energy, multiple arteries and veins is admittedly de-, reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves. De-for the empty wish of body, the cold weak pulse of limb, insufficiency of the spleen food is few, and the deficiency syndrome of the lung is breathed with cough, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, and prolonged illness void is thin, palpitation with fear insomnia, impotence palace is cold; Heart failure, cardiogenic shock.

Lily: sweet, cold. The thoughts of returning home, lung channel. Function cures mainly: Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing. For deficiency of Yin chronic cough, blood-stained sputum, dysphoria palpitation with fear, insomnia and dreamful sleep, absent-minded.

Perny false fairybells rhizome: taste is sweet; Property is put down. Function cures mainly: replenish qi to invigorate the spleen; Yin nourishing and lung moistening; Activate blood and relax tendons. Main puerperal asthenia; Infantile malnutrition; Cough due to yin deficiency; Hidrosis; Dry; Treating swelling and pain by traumatic injury; Rheumatalgia pain; Pain in the back.

Glossy ganoderma: sweet, flat. The thoughts of returning home, lung, liver, kidney channel. Function cures mainly: invigorating qi for tranquilization, and relieving cough and asthma. For dizzy egersis, palpitation, consumptive disease is coughed and is breathed heavily.

Laver: sweet; Salty; Cold. Return lung, spleen, urinary bladder channel. Function cures mainly: resolving phlegm and softening hard masses; Relieve sore throat; Cough-relieving; The relieving restlessness of nourishing heart; Li Shui dehumidifying. Main goiter and tumor; Beriberi; Oedema; Abscess of throat; Cough; Irritated insomnia; Urine leaching pain; Rush down dysentery.

Lance asiabell root: another name: glutinous rehmannia, Omoto Nipponlily Rhizome, ox monkshood, newborn madam, milk tree, lance asiabell root, white boa meat, lance asiabell root, Companumoea root, milk ginseng, newborn potato, logical silkweed, grandmother produce that head, old nipple, edible wild herbs product sand, milk cucurbit, milk mattress, old, milk party, Radix Codonopsis Lanceolatae, MAIMAROU, milk ginseng, angle ginseng, American ginseng, Ha La party, Gou Tou party, dog are joined, dog head is joined. Medicinal material Ji Yuan: be the root of Campanulaceae sheep breast. Latin plant animal mineral name: Codonopsislanceolata (Sieb.Et.Zucc.) Tratn.[CampanumoealanceolataSieb.etZucc.]. Gather and store: the 7-8 month excavates, cleaning, using fresh herb or section are dried. Taste is sweet; Pungent; Property is put down. Return spleen; Lung channel. Function cures mainly: supplementing qi and nourishing yin; Removing toxicity for detumescence; Apocenosis; Logical breast. Main spiritlessness and weakness; Dizziness headache; Lung carbuncle; Acute mastitis; Intestines future; Sore furuncle poison; Tonsillitis; Scrofula; Postpartum, breast was few; Leukorrhea; Venomous snake bite.

Tiger tail wheel: sweet; Micro-hardship; Flat. The thoughts of returning home; Lung; Liver Channel. Function cures mainly: removing heat from the lung to relieve cough; Loose stasis of blood hemostasis. Main cough with lung heat; Lung carbuncle; Gather; Breast blows; Prolapse of the anus; The prolapse of uterus; Spit blood; Hematuria; Traumatism and bleeding.

Evening primrose oil: bitter; Micro-pungent; Micro-sweet; Property is put down. Function cures mainly: promoting blood circulation and removing obstruction in channels; The flat liver of breath wind; Detumescence sore. Main chest impediment and cardialgia; Hemiplegia; Endogenous deficient wind; How moving children's is; Wind dampness rheumatic anesthesia pain; Stomachache is had loose bowels; Dysmenorrhoea; Fox is puzzled; Sore; Eczema.

Tuan linden root: another name: Helwingia himalaica root. Source: medicinal material Ji Yuan: be the root of the blue or green pod leaf of Cornaceae plant Himalaya Helaingia Helwingia chinensis. Latin plant animal mineral name: TiliatuanSzysz.var.chinesisRehd.etwils. Gather and store: all can adopt the whole year, cleaning, section, dries. Taste is pungent; Micro-sweet; Property is put down. Function cures mainly: relieving cough and asthma; Promoting blood circulation and removing obstruction in channels. Main chronic cough void is breathed heavily; Internal lesion caused by overexertion pain in the back; Arthralgia due to wind-dampness; Treating swelling and pain by traumatic injury; Stomachache; Irregular menstruation; Postpartum abdominal pain.

Chinese cabbage: sweet; Cool. Return intestines; Stomach warp. Function cures mainly: antipyretic relieving restlessness; Promote the production of body fluid to quench thirst; Clearing lung-heat dissolving phlegm; Tonneau stomach. Main cough with lung heat; Constipation; Quench one's thirst; Dyspepsia; Erysipelas; Dermatitis rhus.

Holly leaf: hardship, cool. Return liver, kidney channel. Function cures mainly: clearing heat and nourishing yin, flat liver, kidney-nourishing. For tuberculosis spitting of blood, osteopyrexia and fever, has a dizzy spell; Hypertension.

Radix Glycyrrhizae: sweet, flat. Function cures mainly: clearing heat and detoxicating, moisten the lung and relieve the cough, and coordinating the drug actions of a prescription; Honey-fried licorice root can be invigorated the spleen and benefited qi. Cure mainly abscess of throat, cough, weakness of the spleen and the stomach, Stomach duodenum ulcer, hepatitis, hysteria, carbuncle furuncle poison, medicine and food poisoning.

Wilsonii: pungent, micro-hardship, temperature. Return spleen, kidney, the heart channel of Hang-Shaoyin. Function cures mainly: replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain. For the insufficiency of both the spleen and the kindey, body void is weak, poor appetite, soreness of waist and knee joint, insomnia and dreamful sleep.

Sweet potato: sweet; Flat. Function cures mainly: replenish qi to invigorate the spleen; Nourishing yin and supplementing the kidney. Main deficiency of the spleen causing weakness of QI; The full-time weary all cards of kidney yin.

Chinese Ladiestresses Root or Herb: source: medicinal material Ji Yuan: be root and the herb of orchid silk ribbon attached to an official seal or a medal grass. Latin plant animal mineral name: Spiranthessinensis (Pers.) Ames[NeottiasinensisPers.]. Gather and store: summer, autumn gather, using fresh herb or dry. Sweet; Bitter; Flat. The thoughts of returning home; Lung channel. Function cures mainly: supplementing qi and nourishing yin; Clearing heat and detoxicating. Main weak after being ill; Yin asthenia generating intrinsic heat; Cough is spitted blood; Dizzy; Pain in the back is aching and limp; Diabetes; Seminal emission; Under stranguria with turbid discharge band; Abscess of throat; Venomous snake bite; Burn and scald; Sore carbuncle is swollen.

Dog ant grass: another name: chain folder beans, white silk folder beans, small size sickle senna herb or leaf, mountain flower life; Source: pulse familyDog ant grassAlysicarpusvaginalis(L.) DC.[A.mummulariaefoliusDC.], be used as medicine with herb, root, leaf. Habitats distribution: Fujian, Taiwan, Guangxi, Guangdong and Hainan Island. Sweet, bitter, flat. Function cures mainly: promoting blood circulation and removing obstruction in channels, clearing away heat and eliminating dampeness, refutes bone detumescence, removes necrosis and promote granulation.

Sheep dung fruit: another name: 10 years fruits, Ma Li, mountain Portugal, duhat fruit; Source: medicinal material Ji Yuan: be the fruit of myrtle crow China ink. Latin plant animal mineral name: Syzygiumcunini (L.) Skeels[MyrtuscuminiL.; EugeniajambolanaLam.], gather and store: summer and autumn picking fruit, remove carpopodium, dry. Taste is sweet; Acid; Property is put down. Function cures mainly: astringing lung for relieving asthma; Promote the production of body fluid; Puckery intestines. Main phthisical cough; Void is breathed heavily; Tianjin wound is thirsty; Rush down for a long time protracted dysentery.

Radix Angelicae Sinensis: sweet, acrid, warm. Return liver, the heart, the spleen channel. Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relaxes bowel. Sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores. Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation. Be used for through closing dysmenorrhoea arthralgia due to wind-dampness, injury from falling down.

The fruit of Chinese wolfberry: sweet, flat. Return liver, kidney channel. Function cures mainly: nourishing liver and kidney, and benefiting shrewd head. Lose for consumptive disease essence, soreness of waist and knee joint, dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 endo-medicine capsule

The embodiment of the present invention provides a kind of endo-medicine that is used for the treatment of Qi and Yin deficiency diabetes mellitus PVR, is made up of the raw medicinal material of following parts by weight: ginseng 16 weight portions, lily 15 weight portions, perny false fairybells rhizome 12 weight portions, glossy ganoderma 23 weight portions, laver 19 weight portions, lance asiabell root 15 weight portions, brave tail wheel 13 weight portions, evening primrose oil 3 weight portions, tuan linden root 2 weight portions, Chinese cabbage 14 weight portions, holly leaf 13 weight portions and Radix Glycyrrhizae 11 weight portions;

Its preparation method is specially:

The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, adds hot reflux 2 hours, extracts, and filters and obtains the first extract; The ethanol that it is 90% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1.5 times of described dregs of a decoction quality again, adds hot reflux 2 hours, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 2 hours, pulverizes, and sieves, and obtains 350 object micropowders;

The 3rd step, successively adds talcum powder, dolomol in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, dolomol and talcous weight ratio are 100: 0.2:0.3, described capsule 's content is incapsulated in housing, and obtain capsule finished product.

Embodiment 2 endo-medicine tablets

The embodiment of the present invention provides a kind of endo-medicine that is used for the treatment of Qi and Yin deficiency diabetes mellitus PVR, raw medicinal material by following parts by weight is made: ginseng 16 weight portions, lily 15 weight portions, perny false fairybells rhizome 12 weight portions, glossy ganoderma 23 weight portions, laver 19 weight portions, lance asiabell root 15 weight portions, tiger tail wheel 13 weight portions, evening primrose oil 3 weight portions, tuan linden root 2 weight portions, Chinese cabbage 14 weight portions, holly leaf 13 weight portions, Radix Glycyrrhizae 11 weight portions, wilsonii 15 weight portions, sweet potato 8 weight portions, Chinese Ladiestresses Root or Herb 13 weight portions, dog ant grass 14 weight portions and sheep dung fruit 9 weight portions,

Its preparation method is specially:

The first step, mixes each described Chinese medicine raw medicinal material in proportion, and the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, adds hot reflux 2 hours, extracts, and filters and obtains the first extract; The ethanol that it is 90% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 2 times of described dregs of a decoction quality again, adds hot reflux 2 hours, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in micronizer to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 400 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds with respect to the microcrystalline cellulose of 0.2 times of its quality, 0.1 times of lactose, the starch of 0.2 times, sieves, mix, granulate, dry, add with respect to 0.03 times of dolomol of micropowders quality, whole grain, compressing tablet, makes.

Embodiment 3 external used medicines paste navel agent

The present invention provides again the external used medicine that is used for the treatment of diabetic angiopathy, and described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 13 weight portions, ginseng 10 weight portions, glossy ganoderma 21 weight portions, sheep dung fruit 16 weight portions, the fruit of Chinese wolfberry 11 weight portions and Radix Glycyrrhizae 6 weight portions;

Its preparation method is specially:

The first step, mixes described each raw medicinal material in proportion, is ground into 50 object powder, and the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 90%, adds hot reflux 2 hours, extracts, and filters and obtains the first extract; The ethanol that it is 90% that the dregs of a decoction that filtration obtains add with respect to the determining alcohol of 1.5 times of described dregs of a decoction quality again, adds hot reflux 2 hours, extracts, and filters and obtains the second extract; The first extract and the second extract are merged, and reduced pressure concentration is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 150 object powder;

Second step, dissolves stearic acid heating, and remaining on temperature is 75 DEG C, obtains stearic acid liquid; In addition, the part by weight of potassium hydroxide, glycerine, ethylparaben and distilled water being pressed to 5:500:1:600 mixes, and heating, maintains the temperature at 75 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor according to the part by weight of 1:100, stir simultaneously cooling, obtain matrix;

The 3rd step, the powder that adds the first step of equivalent to obtain to the matrix of second step acquisition, and be constantly ground to evenly, heating obtains sticky paste, granulates, and after being dried, obtains pill, coordinates medical proof fabric or special navel paster that pill is attached to navel place.

Embodiment 4 external used medicine eye drops

The present invention provides again the external used medicine that is used for the treatment of diabetic angiopathy, and described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 13 weight portions, ginseng 10 weight portions, glossy ganoderma 21 weight portions, sheep dung fruit 16 weight portions, the fruit of Chinese wolfberry 11 weight portions and Radix Glycyrrhizae 6 weight portions;

Its preparation method is specially:

The first step, described raw medicinal material is mixed in proportion, put into micronizer and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 4 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 90%, stirring and dissolving obtains ethanolic solution, ethanolic solution is left standstill to 29 hours under the condition of 8 DEG C, adopt the speed slowly diacolation of percolation with 2ml per minute, collect percolate, concentrate and be dried, and put into micronizer at this and pulverize 50 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets the mixed powder 3g that second step obtains, and adds sodium chloride 100g, adds 1000ml water for injection, stirs and makes its dissolving; Inject water to 800ml; With 0.22 μ m filtering with microporous membrane; Packing embedding, sterilizing.

Toxicity test

(1) acute toxicity test: 60 of application NIH mouse, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test. Mouse is divided into two groups at random, and 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; Capsule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll. Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.

(2) long term toxicity test: by the tablet of the embodiment of the present invention 2 to mouse by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing. Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mouse long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

(3) acute dermal toxicity test: use the test method(s) of once limiting the quantity, choose 20 of SD rats, male and female half and half, body weight 90g～180g, the pill in the subsides navel agent that the embodiment of the present invention 3 is obtained is pulverized, and once smears 5000mg/kg body weight dosage through skin, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

(4) toxicity test:

Animal is selected 40 of clean level kunming mices, male and female half and half, body weight 18～22g; Laboratory observation 1 week, fasting 4h before each administration, can't help water; To clean above level kunming mice laboratory observation 1 week, the clean level kunming mice of clinical observation result health will be divided into two groups, 20 every group (male and female half and half) at random; Wherein one group is set as experimental group, and another group is set as control group. Mouse tail vein injection, experimental group is with successive administration in eye drops maximum (former) concentration of the embodiment of the present invention 4 and maximum volume 24h 3 times, give 0.6ml/20g(Mouse Weight) medicine, i.e. the parenteral solution 1.8g(crude drug amount of mouse tail vein injection embodiment 2 in 24h)/20g(Mouse Weight); Control group is to the injection physiological saline of same volume. Before administration, weigh the weight of animals and observe feed intake and drinking-water situation; After administration, weigh the weight of animals, feed intake and undue toxicity symptom, Continuous Observation 14d at same time every day. Observation index is as follows: 1. action, as unstability, many moving, sounding; 2. nervous system reaction, as abnormal in lifted tail, chatter, spasm, ataxia, attitude; 3. autonomic nerves system reaction, as exophthalmos ', salivate, shed tears, urinate, drop, perpendicular hair, dermatodyschroia, adnormal respiration; 4. drinking-water and appetite variation, stool and urine and color thereof, whether nose, eye, oral cavity have or not abnormal secretion thing, changes of weight; 5. death condition. By the observation of 14d, two groups all do not have undue toxicity reaction to occur, do not occur yet animal dead phenomenon. Therefore, the eye drops of the embodiment of the present invention 4 has no side effect.

Clinical testing

Case selection: choose the 240 routine Qi and Yin deficiency diabetes mellitus patient with retinopathies that derive from during in January, 2009-2013, the court year December, man's 118 examples, female's 122 examples, age 38-68 year, suffer from diabetic duration the longest 39 years, the shortest 8 years, be all diagnosed as after diagnosing Qi and Yin deficiency diabetes mellitus PVR, and link up all and determine all without carrying out laser photocoagulation treatment according to the state of an illness and with patient.

Patient is divided into embodiment group 1, embodiment group 2, embodiment group 3 and control group at random, every group of 60 people, each experimental group patient age, sex, the equal no difference of science of statistics of the state of an illness.

Diagnostic criteria: the revised standard with reference to ADA in 1997 to WHO diabetes diagnosis standard: (1) has clear and definite diabetes medical history person, and medical history is more than 8 years; (2) diabetic eyeground there is the distinctive microaneurysm of retina, hemorrhage, hard exudate, softly ooze out, retinal neovascularization etc.; (3) eyesight slightly goes down or normally, dryness with foreign body sensation in the eyes, or a little black flower is waved in the wind at the moment, and eyeground is seen a little microaneurysm of retina, is dispersed in hemorrhage and oozes out, and PVR mostly is 1～3 grade; (4) can accompany spiritlessness and weakness, the lazy speech of breathing hard, dry mouth and throat, spontaneous perspiration, just dry or rare half congealed, tongue is fat tender, purple dark or have an ecchymosis, deep,thready and forceless pulse.

Methods for the treatment of:

Embodiment group 1: use the medicine of the embodiment of the present invention 1 and embodiment 3 to treat, capsule every day of embodiment 1 three times, each 4, the navel paster of embodiment 3 pasted once every two days, each 6-12 hour simultaneously; It within one month, is a course for the treatment of;

Embodiment group 2: use the medicine of the embodiment of the present invention 2 and embodiment 4 to treat, tablet every day of embodiment 1 three times, each 3, be a course for the treatment of twice, one month every day of eye drops of embodiment 4 simultaneously;

Embodiment group 3: use the medicine of the embodiment of the present invention 2 to treat, every day three times, each 3 one month is a course for the treatment of;

Control group: use calcium dobesilate capsule (Calcium Dobesilate), nonproliferative retinopathy or invisible PVR 750～1500mg every day, divide and take for 2～3 times; Proliferative retinopathy, 1500～2000mg, divided and took for 3～4 times every day, within one month, was a course for the treatment of.

Criterion of therapeutical effect: clinical cure: retinal hemorrhage point, hard exudate, cotton-wool patches, angiomatoid disappear substantially, eyesight and eye pressure recover; Effective: retinal hemorrhage point, hard exudate and cotton-wool patches obviously reduce, angiomatous change is without increasing, vision restoration, and eye pressure obviously improves; Effective: retinal hemorrhage point, hard exudate and cotton-wool patches obviously reduce, and angiomatous change does not increase, and eyesight is recovered substantially, and eye pressure makes moderate progress; Invalid: retinal hemorrhage point, hard exudate and cotton-wool patches are without changing or increasing, and hemangioma changes and increases, eyesight is without progressive or decline. Wherein, each group in above-mentioned therapeutic process, if patient's symptom, without any improvement, is changed other effective ways such as laser photocoagulation treatment etc. according to the actual state of an illness, and count invalid.

Treatment results:

Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine treatment Qi and Yin deficiency diabetes mellitus PVR of the present invention, in result for the treatment of, there is significant improvement with respect to conventional medicament; As can be seen from Table 2, adopt medicine treatment Qi and Yin deficiency diabetes mellitus PVR of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

Each group of table 1 is treated respectively Clinical efficacy comparison example after 3-8 the course for the treatment of

Group	Number of cases	Clinical cure	Effective	Effectively	Invalid	Cure and obvious effective rate	Total effective rate
								Embodiment group 1	60	14	38	8	0	（52）86.7%	100%
Embodiment group 2	60	17	38	5	0	（55）91.7%	100%
								Embodiment group 3	60	11	37	11	1	（48）80.0%	98.3%
Control group	60	2	19	27	12	（21）35.0%	80.0%

Each group of table 2 is treated respectively clinical cure and effective number and time comparative example (%) after 3-8 the course for the treatment of

Group	Number of cases	3-6 month	7th month	8th month
					Embodiment group 1	52	28(53.8%)	17(32.7%)	7(13.5%)
Embodiment group 2	55	30(54.5%)	19(34.5%)	6(10.9%)
					Embodiment group 3	48	21(43.8%)	20(41.7%)	7(14.6%)
Control group	21	2(9.5%)	8(38.1%)	11(52.4%)

Known according to the clinical statistics in above table, medicine provided by the invention has rapid-action, efficient height, determined curative effect, safe, the advantage that has no side effect; Each group of clinical cure and effective patient are followed up a case by regular visits to 1 year simultaneously, result statistics, 52 examples of embodiment group 1,14 example nothing recurrences of clinical cure, 1 case relapsed in 38 effective routine patients, recurrence rate is 1.9%; 55 examples of embodiment group 2,17 examples of clinical cure are without recurrence, and 38 effective examples are without recurrence, and recurrence rate is 0%; 48 examples of embodiment group 3,11 examples of clinical cure, without recurrence, recur 2 examples in 37 effective routine patients, and recurrence rate is 4.17%; The routine patient of control group 21, in 2 routine patients of healing, recurrence 1 people, in 19 effective routine patients, recurrence 7 people, recurrence rate 38.1%.

The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. be used for the treatment of the medicine of diabetic angiopathy, it is characterized in that, described medicine comprises endo-medicine and external used medicine, and described endo-medicine comprises: ginseng, lily, perny false fairybells rhizome, glossy ganoderma, laver, lance asiabell root, brave tail wheel, evening primrose oil, tuan linden root, Chinese cabbage, holly leaf and Radix Glycyrrhizae; Described external used medicine comprises: Radix Angelicae Sinensis, ginseng, glossy ganoderma, sheep dung fruit, the fruit of Chinese wolfberry and Radix Glycyrrhizae.

2. the medicine that is used for the treatment of diabetic angiopathy according to claim 1, it is characterized in that, described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, brave tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion and Radix Glycyrrhizae 7-14 weight portion.

3. the medicine that is used for the treatment of diabetic angiopathy according to claim 1 and 2, it is characterized in that, described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 10-15 weight portion, ginseng 7-12 weight portion, glossy ganoderma 15-25 weight portion, sheep dung fruit 15-19 weight portion, fruit of Chinese wolfberry 8-15 weight portion and Radix Glycyrrhizae 5-10 weight portion.

4. according to the medicine that is used for the treatment of diabetic angiopathy described in claim 1-3 any one, it is characterized in that, described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 15-17 weight portion, lily 13-17 weight portion, perny false fairybells rhizome 11-14 weight portion, glossy ganoderma 18-26 weight portion, laver 17-21 weight portion, lance asiabell root 14-16 weight portion, brave tail wheel 12-14 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-3 weight portion, Chinese cabbage 13-15 weight portion, holly leaf 12-14 weight portion and Radix Glycyrrhizae 9-12 weight portion.

5. according to the medicine that is used for the treatment of diabetic angiopathy described in claim 1-4 any one, it is characterized in that, described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 12-15 weight portion, ginseng 9-11 weight portion, glossy ganoderma 19-23 weight portion, sheep dung fruit 16-17 weight portion, fruit of Chinese wolfberry 10-13 weight portion and Radix Glycyrrhizae 5-7 weight portion.

6. according to the medicine that is used for the treatment of diabetic angiopathy described in claim 1-3 any one, it is characterized in that, described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 16 weight portions, lily 15 weight portions, perny false fairybells rhizome 12 weight portions, glossy ganoderma 23 weight portions, laver 19 weight portions, lance asiabell root 15 weight portions, brave tail wheel 13 weight portions, evening primrose oil 3 weight portions, tuan linden root 2 weight portions, Chinese cabbage 14 weight portions, holly leaf 13 weight portions and Radix Glycyrrhizae 11 weight portions.

7. according to the medicine that is used for the treatment of diabetic angiopathy described in claim 1-4 any one, it is characterized in that, described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 13 weight portions, ginseng 10 weight portions, glossy ganoderma 21 weight portions, sheep dung fruit 16 weight portions, the fruit of Chinese wolfberry 11 weight portions and Radix Glycyrrhizae 6 weight portions.

8. according to the medicine that is used for the treatment of diabetic angiopathy described in claim 1-7 any one, it is characterized in that, described endo-medicine also comprises wilsonii, sweet potato, Chinese Ladiestresses Root or Herb, dog ant grass and sheep dung fruit, described endo-medicine is made up of the raw medicinal material of following parts by weight: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, tiger tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion, Radix Glycyrrhizae 7-14 weight portion, wilsonii 12-18 weight portion, sweet potato 5-12 weight portion, Chinese Ladiestresses Root or Herb 10-17 weight portion, dog ant grass 11-17 weight portion and sheep dung fruit 7-12 weight portion.

9. be used for the treatment of the endo-medicine of diabetic angiopathy, it is characterized in that, described endo-medicine is made up of the raw medicinal material of following weight amount umber: ginseng 12-19 weight portion, lily 10-20 weight portion, perny false fairybells rhizome 7-16 weight portion, glossy ganoderma 15-30 weight portion, laver 15-23 weight portion, lance asiabell root 12-16 weight portion, brave tail wheel 10-15 weight portion, evening primrose oil 2-4 weight portion, tuan linden root 1-4 weight portion, Chinese cabbage 11-16 weight portion, holly leaf 12-15 weight portion and Radix Glycyrrhizae 7-14 weight portion.

10. be used for the treatment of the external used medicine of diabetic angiopathy, it is characterized in that, described external used medicine is made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 10-15 weight portion, ginseng 7-12 weight portion, glossy ganoderma 15-25 weight portion, sheep dung fruit 15-19 weight portion, fruit of Chinese wolfberry 8-15 weight portion and Radix Glycyrrhizae 5-10 weight portion.