CN105592697B - 包含苯氧乙醇的杀微生物组合物 - Google Patents
包含苯氧乙醇的杀微生物组合物 Download PDFInfo
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- JSTFROSQSCXFPA-UHFFFAOYSA-N 2-methyl-3h-1,2-thiazole Chemical class CN1CC=CS1 JSTFROSQSCXFPA-UHFFFAOYSA-N 0.000 description 1
- UNRLFGKAPAPARO-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazolidine Chemical compound CN1CCC(Cl)S1 UNRLFGKAPAPARO-UHFFFAOYSA-N 0.000 description 1
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- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
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- FVEFRICMTUKAML-UHFFFAOYSA-M sodium tetradecyl sulfate Chemical compound [Na+].CCCCC(CC)CCC(CC(C)C)OS([O-])(=O)=O FVEFRICMTUKAML-UHFFFAOYSA-M 0.000 description 1
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- AKUNSPZHHSNFFX-UHFFFAOYSA-M tributyl(tetradecyl)phosphanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[P+](CCCC)(CCCC)CCCC AKUNSPZHHSNFFX-UHFFFAOYSA-M 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2305/00—Use of specific compounds during water treatment
- C02F2305/04—Surfactants, used as part of a formulation or alone
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
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Abstract
一种协同性杀微生物组合物，其具有两种组分。第一组分是具有以下结构的非离子表面活性剂：R1O(CH2CH(CH3)O)5(CH2CH2O)9H，其中R1是C8烷基。第二组分是苯氧乙醇。非离子表面活性剂与2‑癸基硫乙胺的重量比为1∶1至1∶18.2766。或者，第一组分是具有以下结构的非离子表面活性剂：R2O(CH2CH(CH3)O)3(CH2CH2O)xH，其中R2是C8‑C14直链烷基混合物并且x是5或7。第二组分是苯氧乙醇。在此情况下，非离子表面活性剂与苯氧乙醇的重量比为1∶0.1999至1∶36.5897。
Description
技术领域
本发明涉及包含2-苯氧乙醇和表面活性剂的杀微生物组合物。
背景技术
美国专利号4,295,932中公开了包含5-氯-2-甲基异噻唑啉-3-酮、2-甲基异噻唑啉-3-酮和非离子分散剂的组合物。所述组合物含有5-氯-2-甲基异噻唑啉-3-酮和2-甲基异噻唑啉-3-酮的3:1混合物，以及环氧乙烷与环氧丙烷的共聚物，其看起来具有与普朗尼克L61(PLURONIC L61)或特吉托L61(TERGITOL L61)分散剂相同的组成。然而，需要对多种微生物菌株具有协同活性的杀微生物剂的组合来提供对微生物的有效控制。此外，出于环境和经济益处，需要包含低水平的个别杀微生物剂的这样的组合。由本发明解决的问题是提供此类杀微生物剂的协同组合。
发明内容
本发明涉及一种协同性杀微生物组合物，其包含：(a)具有以下结构的非离子表面活性剂：
R1O(CH2CH(CH3)O)5(CH2CH2O)9H
其中R1是C8烷基；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:1至1:18.2766。
本发明还涉及一种协同性杀微生物组合物，其包含：(a)具有以下结构的非离子表面活性剂：
R2O(CH2CH(CH3)O)3(CH2CH2O)xH
其中R2是C8-C14直链烷基混合物，并且x是5至7的整数；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:0.1999至1:36.5897。
具体实施方式
“苯氧乙醇”是2-苯氧基-1-乙醇(CAS号122-99-6)。除非上下文另外明确指出，否则本文中使用的以下术语具有指定定义。术语“杀微生物剂”指能够抑制微生物生长或控制微生物生长的化合物；杀微生物剂包括杀细菌剂、杀真菌剂和杀藻剂。术语“微生物”包括例如真菌(例如酵母和霉菌)、细菌和藻类。本说明书通篇使用以下缩写：ppm＝按重量计的百万分率(重量/重量)，mL＝毫升。除非另外说明，否则温度以摄氏度(℃)表示，提及百分比为重量百分比(重量％)并且量和比率是以活性成分为基础，即苯氧乙醇和非离子表面活性剂的总重量。环氧丙烷或环氧乙烷的聚合单元的数目为平均数。
优选地，具有以下结构的非离子表面活性剂与苯氧乙醇的重量比为1:1.5992至1:18.2766，优选1:1至1:2：R1O(CH2CH(CH3)O)5(CH2CH2O)9H，其中R1是C8烷基。优选地，C8烷基为2-乙基己基。T本发明还涉及用于在水性介质中抑制微生物生长的方法，其通过向所述水性介质添加所述非离子表面活性剂和苯氧乙醇进行；其中非离子表面活性剂与苯氧乙醇的重量比为1:1至1:18.2766。本发明还涉及用于在水性介质中抑制绿脓杆菌(P.aeruginosa)生长的方法，其通过向所述水性介质添加所述非离子表面活性剂和苯氧乙醇进行；其中非离子表面活性剂与苯氧乙醇的重量比为1:1.5992至1:18.2766。
当将具有结构R2O(CH2CH(CH3)O)3(CH2CH2O)xH(其中R2是C8-C14直链烷基混合物并且x是5至7的整数)的非离子表面活性剂与苯氧乙醇组合时，优选地C8-C14直链烷基包含50重量％至85重量％的C8-C10直链烷基和15重量％至50重量％的C12-C14直链烷基，优选60重量％至75重量％的C8-C10直链烷基和25重量％至40重量％的C12-C14直链烷基，优选约70重量％的C8-C10直链烷基和约30重量％的C12-C14直链烷基。优选地，所述直链烷基来源于籽油。优选地，x是5或7。当x是5时，优选地非离子表面活性剂与苯氧乙醇的重量比为1:0.1999至1:36.5877。当x是7时，优选地非离子表面活性剂与苯氧乙醇的重量比为1:0.7996至1:27.6，优选1:1至1:6。本发明还涉及用于在水性介质中抑制微生物生长的方法，其通过向所述水性介质添加所述非离子表面活性剂和苯氧乙醇进行；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:0.1999至1:36.5897。本发明还涉及用于在水性介质中抑制金黄色葡萄球菌(S.aureus)生长的方法，其通过向所述水性介质添加具有以下结构的表面活性剂和苯氧乙醇进行：R2O(CH2CH(CH3)O)3(CH2CH2O)5H，其中R2是C8-C14直链烷基混合物；其中非离子表面活性剂与苯氧乙醇的重量比为1:0.1999至1:36.5897。本发明还涉及用于在水性介质中抑制霉菌(优选黑曲霉(A.niger))生长的方法，其通过向所述水性介质添加具有以下结构的表面活性剂和苯氧乙醇进行：R2O(CH2CH(CH3)O)3(CH2CH2O)5H，其中R2是C8-C14直链烷基混合物；其中非离子表面活性剂与苯氧乙醇的重量比为1:0.3998至1:13.7006。本发明还涉及用于在水性介质中抑制金黄色葡萄球菌生长的方法，其通过向所述水性介质添加具有以下结构的表面活性剂和苯氧乙醇进行：R2O(CH2CH(CH3)O)3(CH2CH2O)7H，其中R2是C8-C14直链烷基混合物；其中非离子表面活性剂与苯氧乙醇的重量比为1:0.7996至1:27.4377。在前述各种方法中，直链烷基的优选组成如本段中早前所述。
优选地，每种协同性杀微生物组合物基本不含除非离子表面活性剂和苯氧乙醇之外的杀微生物剂，即，其具有基于活性成分总重量低于1重量％的除非离子表面活性剂和苯氧乙醇之外的杀微生物剂，优选低于0.5重量％，优选低于0.2重量％，优选低于0.1重量％。优选地，当向水性介质添加非离子表面活性剂和苯氧乙醇时，所述介质基本不含其他杀微生物剂，即，其具有基于活性成分总重量低于1重量％的除非离子表面活性剂和苯氧乙醇之外的杀微生物剂，优选低于0.5重量％，优选低于0.2重量％，优选低于0.1重量％。
本发明的组合物可包含其他活性成分，例如消泡剂和乳化剂。本发明的杀微生物组合物通过向经受微生物攻击的水性介质中引入杀微生物有效量的所述组合物可用于抑制微生物或更高等形式水生生物(例如原生动物、无脊椎动物、苔藓虫类、沟鞭藻类、甲壳动物、软体动物等)的生长。合适的水性介质见于以下中，例如：工业生产用水；电涂层沉积***；冷却塔；空气洗涤器；气体洗涤塔；矿物浆料；废水处理；观赏性喷泉；逆渗透过滤；超滤；压载水；蒸发冷凝器；热交换器；纸浆及纸加工流体和添加剂；淀粉；塑料；乳液；分散体；漆料；乳胶；涂料，例如清漆；建筑用产品，例如胶泥(mastic)、填缝剂和密封剂；建筑用粘合剂，例如陶瓷粘合剂、地毯背衬粘合剂和层压粘合剂；工业用或消费者用粘合剂；摄影用化学品；印刷用流体；家用产品，例如浴室和厨房清洁剂；化妆品；洗漱用品；洗发剂；肥皂；个人护理产品，例如湿巾、洗液、防晒品、调理剂、霜以及其他免洗型应用；洗涤剂；工业用清洁剂；地板抛光剂；洗衣漂洗水；金属加工流体；传送机润滑剂；液压流体；皮革及皮革产品；织物；纺织品；木材及木材产品，例如胶合板、木屑板(chipboard)、碎料板(flakeboard)、叠层梁、定向刨花板(oriented strandboard)、硬纸板和芯板材(particleboard)；石油加工流体；燃料；油田用流体，例如注射水、压裂液和钻探泥浆；农业辅助剂保存；表面活性剂保存；医疗装置；诊断试剂保存；食品保存，例如；塑料或纸质食品包装；食品、饮料和工业生产巴氏灭菌器；抽水马桶；娱乐用水；水池；以及矿泉。
在应用中抑制或控制微生物生长所必需的本发明杀微生物组合物的具体量将改变。典型地，如果本发明组合物的量提供1,000至20,000ppm(百万分率)的所述组合物的活性成分，则其足以控制微生物的生长。优选地，所述组合物的活性成分(即，非离子表面活性剂和苯氧乙醇)以至少2,000ppm，优选至少3,000ppm，优选至少4,000ppm的量存在于待处理的介质中。优选地，所述组合物的活性成分以以下量存在于所在介质：不超过16,000ppm，优选不超过14,000ppm，优选不超过12,000ppm，优选不超过10,000ppm，优选不超过8,000ppm，优选不超过7,000ppm。在本发明的方法中，通过同时或单独添加将产生上述浓度的量的非离子表面活性剂和苯氧乙醇来处理组合物以抑制微生物生长。
实例
通过确定组合的协同指数(synergy index，S.I.)来评价表面活性剂和杀生物剂的协同作用。基于两种抗微生物化合物(A和B)单独和组合时的最小抑制浓度(minimuminhibitory concentration，MIC)来计算协同指数。受试生物为革兰氏阴性细菌(绿脓杆菌(Pseudomonas aeruginosa)ATCC#15442)、***(金黄色葡萄球菌(Staphylococcus aureus)ATCC#6538)、酵母(白念珠菌(Candida albicans)ATCC#10203)和霉菌(黑曲霉(Aspergillus niger)ATCC#16404)。细菌的接触时间为24和48小时，酵母为48和72小时，并且霉菌为3和7天。在96孔微量滴定板中进行测试。
表面活性剂.A R1O(CH2CH(CH3)O)5(CH2CH2O)9H，其中R1是2-乙基己基
表面活性剂.D R2O(CH2CH(CH3)O)3(CH2CH2O)5H
表面活性剂.E R2O(CH2CH(CH3)O)3(CH2CH2O)7H
在表面活性剂D和表面活性剂E中，R2是C8-C14直链烷基混合物(70％的C8-C10直链烷基和30％的C12-C14直链烷基)。
使用的接种物
表4.使用的培养基
胰蛋白酶大豆肉汤的pH为7.3，并且马铃薯右旋糖肉汤的pH为5.1。
用于证明MIC组合的协同作用的测试结果示于以下表格中。每个表格示出了两种组分之组合随着孵育时间抵抗受试微生物的结果；通过MIC以ppm测量的化合物A单独(CA)、组分B单独(CB)和混合物((Ca)和(Cb))的终点活性；计算的SI值；以及每个受试组合的协同比的范围。SI如下计算：
Ca/CA+Cb/CB＝协同指数("SI")
其中：
CA＝化合物A单独作用时产生终点的以ppm表示的浓度(化合物A的MIC)。
Ca＝化合物A在混合物中时产生终点的以ppm表示的浓度。
CB＝化合物B单独作用时产生终点的以ppm表示的浓度(化合物B的MIC)。
Cb＝化合物B在混合物中时产生终点的以ppm表示的浓度。
当Ca/CA和Cb/CB之和大于1时，表示拮抗作用。当所述和等于1时，表示加和作用，并且当小于1时，证明协同作用。
苯氧乙醇和表面活性剂所测试的比率范围如以下表格中所总结：
A：表面活性剂A
B：苯氧乙醇
黑曲霉 ATCC#16404 无协同作用
白念珠菌 ATCC#10203 无协同作用
A：表面活性剂A
B：苯氧乙醇
培养基：1/10TSB
接种物数量：8.134E+07CFU/ml
A：表面活性剂A
B：苯氧乙醇
培养基：1/10TSB
接种物数量：1.156E+06CFU/ml
A：表面活性剂D
B：苯氧乙醇
培养基：PDB
接种物数量：1.156E+06
A：表面活性剂D
B：苯氧乙醇
培养基：PDB
接种物量：5.726E+05CFU/ml
A：表面活性剂D
B：苯氧乙醇
培养基：1/10TSB
接种物量：1.16E+08
A：表面活性剂D
B：苯氧乙醇
培养基：1/10TSB
接种物量：1.808E+05
A：表面活性剂E
B：苯氧乙醇
黑曲霉 ATCC#16404 无协同作用
白念珠菌 ATCC#10203 无协同作用
A：表面活性剂E
B：苯氧乙醇
培养基：1/10TSB
接种物量：5.727E+07CFU/ml
A：表面活性剂E
B：苯氧乙醇
培养基：1/10TSB
接种物量：1.808E+06CFU/ml
以下杀生物剂当与以下表面活性剂配对时对测试的任何生物不具协同作用：
表面活性剂A
苯甲酸钠，Tris Nitro
表面活性剂E
DMDMH
表面活性剂D
CS-1246，OPP，DMDMH
在以下组合中，观察到协同作用的表面活性剂与杀生物剂的比率不是商业相关的，即1:0.2或更大的比率(相对于表面活性剂，杀生物剂较少)。在这些比率下，配制品中的杀生物剂水平将太低而不实用：
表面活性剂A
DIDAC，IPBC
表面活性剂E
CMIT/MIT，IPBC，OIT，TTPC，WSCP
表面活性剂D
CMIT/MIT，OIT，DIDAC
(MBIT、IPBC、WSCP仅在1:0.05下协同作用，或更糟的是，仅一个数据点除外)
稳定性测试
制备苯甲酸钠或山梨酸钾于水中的溶液且用表面活性剂稀释获得所要的杀生物剂比表面活性剂的比率。根据需要，再添加70％异丙醇以得到苯氧乙醇的33重量％溶液。将试样分配到三个小瓶中。将一个小瓶储存在室温下，一个储存在40℃下并且一个储存在50℃下。一周后，对试样进行评价以确定稳定性。混浊或高度变色的样品判断为不稳定。在数据表中，破折号表示配制物是稳定的。
稳定性数据-33％苯氧乙醇(PE)与表面活性剂的组合-第1天
*表面活性剂B是R1O(CH2CH(CH3)O)5(CH2CH2O)6H，其中R1是2-乙基己基
稳定性数据-33％苯氧乙醇(PE)与表面活性剂的组合-第2天
稳定性数据-33％苯氧乙醇(PE)与表面活性剂的组合-第7天
Claims (6)
1.一种协同性杀微生物组合物，其包含：(a)具有以下结构的非离子表面活性剂：
R1O(CH2CH(CH3)O)5(CH2CH2O)9H
其中R1是C8烷基；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:1至1:18.2766，其中所述C8烷基是2-乙基己基。
2.一种用于在水性介质中抑制微生物生长的方法；所述方法包括向所述水性介质添加：(a)具有以下结构的非离子表面活性剂：
R1O(CH2CH(CH3)O)5(CH2CH2O)9H
其中R1是C8烷基；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:1至1:18.2766，其中所述C8烷基是2-乙基己基。
3.一种协同性杀微生物组合物，其包含：(a)具有以下结构的非离子表面活性剂：
R2O(CH2CH(CH3)O)3(CH2CH2O)xH
其中R2是C8-C14直链烷基混合物并且x是5至7的整数；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:0.1999至1:36.5897，其中所述C8-C14直链烷基混合物包含60重量％至75重量％的C8-C10直链烷基和25重量％至40重量％的C12-C14直链烷基。
4.根据权利要求3所述的协同性杀微生物组合物，其中x是5。
5.根据权利要求3所述的协同性杀微生物组合物，其中x是7，并且所述重量比为1:0.7996至1:27.4377。
6.一种用于在水性介质中抑制微生物生长的方法；所述方法包括向所述水性介质添加：(a)具有以下结构的非离子表面活性剂：
R2O(CH2CH(CH3)O)3(CH2CH2O)xH
其中R2是C8-C14直链烷基混合物并且x是5至7的整数；和(b)苯氧乙醇；其中所述非离子表面活性剂与苯氧乙醇的重量比为1:0.199至1:36.5897，其中所述C8-C14直链烷基混合物包含60重量％至75重量％的C8-C10直链烷基和25重量％至40重量％的C12-C14直链烷基。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4295932A (en) * | 1980-07-14 | 1981-10-20 | Naloc Chemical Company | Synergistic blend of biocides |
| US6413921B1 (en) * | 2000-08-01 | 2002-07-02 | Allegiance Corporation | Antimicrobial composition containing parachlorometaxylenol (PCMX) |
| CN102575195A (zh) * | 2009-10-15 | 2012-07-11 | 狮王株式会社 | 液体清洗剂组合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3525773A (en) * | 1968-04-01 | 1970-08-25 | Jefferson Chem Co Inc | Process for preparing aryloxyalkanols |
| GB2138798A (en) | 1983-04-25 | 1984-10-31 | Dearborn Chemicals Ltd | Biocide |
| JPH02240662A (ja) * | 1989-03-15 | 1990-09-25 | Canon Inc | 一成分現像方式 |
| RU2029738C1 (ru) * | 1990-05-21 | 1995-02-27 | Одесский государственный университет им.И.И.Мечникова | Способ очистки сточных вод от катионных поверхностно-активных веществ |
| US6241898B1 (en) | 1996-04-19 | 2001-06-05 | Betzdearborn Inc. | Method for inhibiting microbial adhesion on surfaces |
| US6039965A (en) | 1996-09-27 | 2000-03-21 | Calgon Corporation | Surfanctants for reducing bacterial adhesion onto surfaces |
| JP4597318B2 (ja) * | 2000-06-21 | 2010-12-15 | ピジョン株式会社 | 防腐抗菌性が改善された水性組成物 |
| JP4252293B2 (ja) * | 2002-11-25 | 2009-04-08 | 花王株式会社 | 食器用抗菌液体洗浄剤 |
| DE10309425B4 (de) | 2003-03-05 | 2010-12-30 | Bk Giulini Gmbh | Mikrobizid zur Desinfektion von industriellen Wasserkreisläufen |
| DE102005044855A1 (de) * | 2005-09-21 | 2007-03-29 | Clariant Produkte (Deutschland) Gmbh | Biozide Zusammensetzungen |
| GB0524927D0 (en) * | 2005-12-07 | 2006-01-18 | Reckitt Benckiser Nv | Compositions and method |
| CA2660048A1 (en) | 2006-08-04 | 2008-02-14 | Stepan Company | Biocidal compositions and methods |
| CN101578130A (zh) * | 2007-01-11 | 2009-11-11 | 陶氏环球技术公司 | 烷氧基化物混合物表面活性剂 |
| US7521412B2 (en) * | 2007-05-25 | 2009-04-21 | Ecolab Inc. | Dimensionally stable solid rinse aid |
| RU2420960C1 (ru) * | 2007-08-31 | 2011-06-20 | Ниппон Сода Ко., Лтд. | Композиция пестицида с усиленной эффективностью и способы усиления эффективности активных ингредиентов пестицида |
| BRPI0909922A2 (pt) * | 2008-06-18 | 2019-03-06 | Dow Global Technologies Inc | método para remover triglicerídeos reticulados a partir de uma espuma e uso de um surfactante não-iônico |
| US20130053422A1 (en) | 2010-03-23 | 2013-02-28 | Sarah L. Edmonds | Antimicrobial Compositions |
| KR20130073674A (ko) * | 2011-12-23 | 2013-07-03 | 씨제이제일제당 (주) | 폴리에틸렌 글리콜계 비이온성 계면 활성제를 이용한 균체의 사멸화 방법 및 그 사멸화 균체 |
-
2014
- 2014-10-02 CN CN201480052698.XA patent/CN105592697B/zh active Active
- 2014-10-02 EP EP14793673.6A patent/EP3027019B1/en active Active
- 2014-10-02 BR BR112016006522A patent/BR112016006522A2/pt not_active Application Discontinuation
- 2014-10-02 JP JP2016517312A patent/JP6535658B2/ja active Active
- 2014-10-02 RU RU2016117114A patent/RU2676479C2/ru not_active IP Right Cessation
- 2014-10-02 US US15/026,126 patent/US9585389B2/en active Active
- 2014-10-02 MX MX2016003698A patent/MX360737B/es active IP Right Grant
- 2014-10-02 KR KR1020167010032A patent/KR102416800B1/ko active IP Right Grant
- 2014-10-02 WO PCT/US2014/058819 patent/WO2015051115A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4295932A (en) * | 1980-07-14 | 1981-10-20 | Naloc Chemical Company | Synergistic blend of biocides |
| US6413921B1 (en) * | 2000-08-01 | 2002-07-02 | Allegiance Corporation | Antimicrobial composition containing parachlorometaxylenol (PCMX) |
| CN102575195A (zh) * | 2009-10-15 | 2012-07-11 | 狮王株式会社 | 液体清洗剂组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US9585389B2 (en) | 2017-03-07 |
| RU2016117114A (ru) | 2017-11-10 |
| CN105592697A (zh) | 2016-05-18 |
| JP2016531867A (ja) | 2016-10-13 |
| KR20160058876A (ko) | 2016-05-25 |
| KR102416800B1 (ko) | 2022-07-04 |
| JP6535658B2 (ja) | 2019-06-26 |
| WO2015051115A1 (en) | 2015-04-09 |
| EP3027019B1 (en) | 2017-06-28 |
| MX2016003698A (es) | 2016-05-24 |
| MX360737B (es) | 2018-11-14 |
| BR112016006522A2 (pt) | 2017-08-01 |
| US20160219875A1 (en) | 2016-08-04 |
| RU2676479C2 (ru) | 2018-12-29 |
| RU2016117114A3 (zh) | 2018-07-09 |
| EP3027019A1 (en) | 2016-06-08 |
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